gastric fundus

Summary

Summary: The superior portion of the body of the stomach above the level of the cardiac notch.

Top Publications

  1. pmc KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus
    V Ipavec
    Institute of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, L go F Vito 1, 00168 Rome, Italy
    Pharmacol Res 64:397-409. 2011
  2. ncbi Lower ghrelin levels and exaggerated postprandial peptide-YY, glucagon-like peptide-1, and insulin responses, after gastric fundus resection, in patients undergoing Roux-en-Y gastric bypass: a randomized clinical trial
    Aikaterini Chronaiou
    Division of Endocrinology, Department of Internal Medicine, School of Medicine, University of Patras, Patras, Greece
    Obes Surg 22:1761-70. 2012
  3. ncbi Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle
    Susumu Ohya
    Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabedori, Mizuhoku, Nagoya 467 8603, Japan
    Am J Physiol Gastrointest Liver Physiol 282:G277-87. 2002
  4. pmc Effect of diabetes on relaxations to non-adrenergic, non-cholinergic nerve stimulation in longitudinal muscle of the rat gastric fundus
    K M Jenkinson
    Department of Medical Laboratory Science, Royal Melbourne Institute of Technology, Victoria, Australia
    Br J Pharmacol 116:1551-6. 1995
  5. ncbi Role of beta-3-adrenoceptor in catecholamine-induced relaxations in gastric fundus from control and diabetic rats
    Isil Ozakca
    Department of Pharmacology, Faculty of Pharmacy, Ankara University, Tandogan Ankara, Turkey
    Pharmacology 80:227-38. 2007
  6. ncbi Altered non-adrenergic non-cholinergic neurotransmission in gastric fundus from streptozotocin-diabetic rats
    K M Jenkinson
    Department of Anatomy and Cell Biology, University of Melbourne, Victoria 3010M, Parkville, Australia
    Eur J Pharmacol 401:251-8. 2000
  7. pmc Loss of enteric motor neurotransmission in the gastric fundus of Sl/Sl(d) mice
    Elizabeth A H Beckett
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA
    J Physiol 543:871-87. 2002
  8. ncbi L-citrulline recycling by argininosuccinate synthetase and lyase in rat gastric fundus
    Lieve A Van Geldre
    Heymans Institute of Pharmacology, Ghent University, De Pintelaan 185, B 9000 Gent, Belgium
    Eur J Pharmacol 455:149-60. 2002
  9. ncbi Properties of Rikkunshi-to (TJ-43)-induced relaxation of rat gastric fundus smooth muscles
    Yoshihiko Kito
    Dept of Physiology, Nagoya City Univ Medical School, Mizuho ku, Nagoya, Japan
    Am J Physiol Gastrointest Liver Physiol 298:G755-63. 2010
  10. ncbi Myosin light chain phosphatase activation is involved in the hydrogen sulfide-induced relaxation in mouse gastric fundus
    Ingeborg Dhaese
    Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium
    Eur J Pharmacol 606:180-6. 2009

Research Grants

  1. Oxyntic Atrophy and Novel Gastric Lineages
    JAMES RICHARD GOLDENRING; Fiscal Year: 2013
  2. Image-guided Bariatric Arterial Embolization (BAE) for the Treatment of Obesity
    CLIFFORD RAABE WEISS; Fiscal Year: 2013
  3. PROSTAGLANDINS AND LOCAL CONTROL OF THE CIRCULATION
    ALAN NIES; Fiscal Year: 1990
  4. H+ NEUTRALIZATION AND C1- HOMEOSTASIS IN GASTRIC MUCOSA
    David Soybel; Fiscal Year: 2002
  5. ELECTROPHYSIOLOGY OF GASTRIC ION TRANSPORT
    JEFFREY DEMAREST; Fiscal Year: 1991
  6. VAGAL GASTRIC MOTOR CONTROL IN MICE
    ELITA PARTOSEOEDARSO; Fiscal Year: 2002
  7. ELECTRICAL CONTROL OF GASTRODUODENAL MOTILITY
    KENTON SANDERS; Fiscal Year: 2003
  8. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 2009
  9. HUS Pathogenesis & clinical Outcome in an in vivo model
    James Fox; Fiscal Year: 2008
  10. GASTRIC ENTEROCHROMAFFIN-LIKE CELL IN ULCER DISEASE
    George Sachs; Fiscal Year: 2005

Detail Information

Publications214 found, 100 shown here

  1. pmc KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus
    V Ipavec
    Institute of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, L go F Vito 1, 00168 Rome, Italy
    Pharmacol Res 64:397-409. 2011
    ..The aims of the present study were to investigate the motor effects of KV7 channel modulators in the rat gastric fundus and the expression of KV7 channels in this tissue...
  2. ncbi Lower ghrelin levels and exaggerated postprandial peptide-YY, glucagon-like peptide-1, and insulin responses, after gastric fundus resection, in patients undergoing Roux-en-Y gastric bypass: a randomized clinical trial
    Aikaterini Chronaiou
    Division of Endocrinology, Department of Internal Medicine, School of Medicine, University of Patras, Patras, Greece
    Obes Surg 22:1761-70. 2012
    ..The purpose of this study was to evaluate whether gastric fundus resection in patients undergoing LRYGBP enhances the efficacy of the procedure in terms of weight loss, ..
  3. ncbi Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle
    Susumu Ohya
    Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabedori, Mizuhoku, Nagoya 467 8603, Japan
    Am J Physiol Gastrointest Liver Physiol 282:G277-87. 2002
    ..The membrane depolarization by 1 microM E-4031 indicates the contribution of K(+) channels encoded by ERG1/KCNE2 to the resting membrane potential in stomach SMCs...
  4. pmc Effect of diabetes on relaxations to non-adrenergic, non-cholinergic nerve stimulation in longitudinal muscle of the rat gastric fundus
    K M Jenkinson
    Department of Medical Laboratory Science, Royal Melbourne Institute of Technology, Victoria, Australia
    Br J Pharmacol 116:1551-6. 1995
    ..on relaxations to non-adrenergic, non-cholinergic (NANC) nerve stimulation in longitudinal strips of rat gastric fundus. 2...
  5. ncbi Role of beta-3-adrenoceptor in catecholamine-induced relaxations in gastric fundus from control and diabetic rats
    Isil Ozakca
    Department of Pharmacology, Faculty of Pharmacy, Ankara University, Tandogan Ankara, Turkey
    Pharmacology 80:227-38. 2007
    The contribution of beta-adrenoceptor subtypes to the catecholamine-mediated relaxations in gastric fundus from control and streptozotocin (STZ)-induced diabetic rats were investigated...
  6. ncbi Altered non-adrenergic non-cholinergic neurotransmission in gastric fundus from streptozotocin-diabetic rats
    K M Jenkinson
    Department of Anatomy and Cell Biology, University of Melbourne, Victoria 3010M, Parkville, Australia
    Eur J Pharmacol 401:251-8. 2000
    ..diabetes has been investigated on responses to non-adrenergic, non-cholinergic (NANC) nerve stimulation in rat gastric fundus. NANC relaxations in precontracted muscle strips from diabetic rats were smaller than those from control rats...
  7. pmc Loss of enteric motor neurotransmission in the gastric fundus of Sl/Sl(d) mice
    Elizabeth A H Beckett
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA
    J Physiol 543:871-87. 2002
    ..IC-IM were found within the circular and longitudinal muscles of the gastric fundus of wild-type mice...
  8. ncbi L-citrulline recycling by argininosuccinate synthetase and lyase in rat gastric fundus
    Lieve A Van Geldre
    Heymans Institute of Pharmacology, Ghent University, De Pintelaan 185, B 9000 Gent, Belgium
    Eur J Pharmacol 455:149-60. 2002
    The aim of this study was to investigate in rat gastric fundus whether L-citrulline, the co-product in the nitric oxide (NO) biosynthesis catalyzed by neuronal nitric oxide synthase (nNOS), can be converted back to the nNOS substrate L-..
  9. ncbi Properties of Rikkunshi-to (TJ-43)-induced relaxation of rat gastric fundus smooth muscles
    Yoshihiko Kito
    Dept of Physiology, Nagoya City Univ Medical School, Mizuho ku, Nagoya, Japan
    Am J Physiol Gastrointest Liver Physiol 298:G755-63. 2010
    The relaxant effects of Rikkunshi-to (TJ-43), a gastroprotective herbal medicine, on rat gastric fundus were investigated. Experiments were carried out using standard tension and intracellular microelectrode recording techniques...
  10. ncbi Myosin light chain phosphatase activation is involved in the hydrogen sulfide-induced relaxation in mouse gastric fundus
    Ingeborg Dhaese
    Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium
    Eur J Pharmacol 606:180-6. 2009
    ..The influence of H(2)S on contractility in mouse gastric fundus was therefore examined...
  11. ncbi Hydrogen peroxide and antioxidizing enzymes involved in modulation of transient facilitatory effects of nicotine on neurogenic contractile responses in rat gastric fundus
    Sevil Ozger Ilhan
    Department of Pharmacology, Medical School, UfukUniversity, Ankara, Turkey
    Eur J Pharmacol 587:267-72. 2008
    ..g. neurotransmitter release. Previously in rabbit gastric fundus we demonstrated that nicotine transiently increased neurogenic contraction induced by electrical field ..
  12. ncbi The involvement of phospholipase A(2) in ethanol-induced gastric muscle contraction
    S S Sim
    Department of Pathophysiology, College of Pharmacy, Chung-Ang University, 221 Huksuk-dong, Dongjak-gu, Seoul 156-756, South Korea
    Eur J Pharmacol 413:281-5. 2001
    ..It is suggested from the above results that ethanol-induced contraction in cat gastric smooth muscle is, in part, mediated by phospholipase A(2) and cyclooxygenase pathways...
  13. ncbi Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons
    S M Ward
    Department of Physiology, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    J Neurosci 20:1393-403. 2000
    ..The role of intramuscular ICC (IC-IM) in mediating enteric excitatory neural inputs was studied using gastric fundus muscles of wild-type animals and W/W(v) mutant mice, which lack IC-IM...
  14. ncbi Effects of vitamin E, vitamin C, and selenium on gastric fundus in cadmium toxicity in male rats
    Sema Bolkent
    Department of Medical Biology, Faculty of Cerrahpasa Medicine, Istanbul University, Istanbul, Turkey
    Int J Toxicol 27:217-22. 2008
    ..tissue glutathione, and lipid peroxidation (LPO) levels, and ghrelin and metallothionein production in the gastric fundus mucosa of rats. Cd (2 mg/kg/day CdCl(2)) was administered to rats for 8 days, intraperitoneally...
  15. ncbi Leptin receptor expression in nodose ganglion cells projecting to the rat gastric fundus
    Christian Peiser
    Division of Allergy Research, Department of Pediatric Pneumology and Immunology, Charite, Virchow Campus, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Neurosci Lett 320:41-4. 2002
    ..Tracing studies revealed that a significant proportion (15%) of the immunopositive neurons projected to the gastric fundus. These findings suggest that leptin may use a neural route to relay its message from peripheral sites of ..
  16. pmc Role of nitric oxide- and vasoactive intestinal polypeptide-containing neurones in human gastric fundus strip relaxations
    M Tonini
    Department of Internal Medicine and Therapeutics, Division of Experimental and Clinical Pharmacology, University of Pavia, Italy
    Br J Pharmacol 129:12-20. 2000
    ..correlates of nitric oxide (NO) and vasoactive intestinal polypeptide (VIP) innervation in the human isolated gastric fundus was explored...
  17. ncbi Comparison of the effect of vasoactive intestinal polypeptide and non-adrenergic non-cholinergic neurone stimulation in the cat gastric fundus
    M D'Amato
    Heymans Institute of Pharmacology, University of Gent Medical School, Belgium
    Eur J Pharmacol 152:71-82. 1988
    ..of vasoactive intestinal polypeptide (VIP) in the non-adrenergic non-cholinergic (NANC) relaxation of the cat gastric fundus was studied in circular and longitudinal muscle strips...
  18. ncbi Investigation of the potential modulatory effect of biliverdin, carbon monoxide and bilirubin on nitrergic neurotransmission in the pig gastric fundus
    Erwin E Colpaert
    Heymans Institute of Pharmacology, Ghent University, De Pintelaan 185, B 9000 Ghent, Belgium
    Eur J Pharmacol 457:177-86. 2002
    In porcine gastric fundus, we have investigated the colocalization of the bile pigment biosynthetic enzymes heme oxygenase-2 and biliverdin reductase with neuronal nitric oxide synthase (nNOS), the effect of carbon monoxide (CO) on fundic ..
  19. ncbi Involvement of peptide histidine isoleucine in non-adrenergic non-cholinergic relaxation of the rat gastric fundus induced by high-frequency neuronal firing
    Diego Currò
    Institute of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, L go F Vito, 1, 00168 Rome, Italy
    Naunyn Schmiedebergs Arch Pharmacol 366:578-86. 2002
    ..of VIP- and PHI-like immunoreactivity (LI) co-released by neuronal activation were investigated in the rat gastric fundus. Longitudinal muscle strips from the rat gastric fundus precontracted by the thromboxane receptor agonist ..
  20. ncbi A putative role for S-nitrosoglutathione as the source of nitric oxide in photorelaxation of the mouse gastric fundus
    Nuran Ogulener
    Department of Pharmacology, Faculty of Medicine, Cukurova University, 01330 Adana, Turkey
    Eur J Pharmacol 450:267-75. 2002
    Mouse gastric fundus strips were relaxed by ultraviolet light (UV) irradiation, exogenous nitric oxide (NO), isoproterenol, S-nitrosoglutathione, S-nitroso-L-cysteine and S-nitroso-N-acetyl-penicillamine...
  21. ncbi Novel human and mouse genes encoding a shank-interacting protein and its upregulation in gastric fundus of W/WV mouse
    Yataro Daigo
    Department of Medicine, University of Yamanashi Medical School, Yamanashi, Japan
    J Gastroenterol Hepatol 18:712-8. 2003
    ..The muscle layers of the gastric fundus do not have IC-MY, therefore electric slow waves are not generated...
  22. pmc Evidence for an apamin-sensitive, but not purinergic, component in the nonadrenergic noncholinergic relaxation of the rat gastric fundus
    Diego Currò
    Institute of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, L go F Vito, 1, I 00168 Rome, Italy
    Br J Pharmacol 143:785-93. 2004
    ..EFS)-induced nonadrenergic noncholinergic (NANC) relaxation of longitudinal muscle strips from the rat gastric fundus was investigated...
  23. pmc Influence of NG-nitro-L-arginine on non-adrenergic non-cholinergic relaxation in the guinea-pig gastric fundus
    R A Lefebvre
    Heymans Institute of Pharmacology, University of Gent Medical School, Belgium
    Br J Pharmacol 106:173-9. 1992
    ..induced by electrical field stimulation was investigated in circular muscle strips of the guinea-pig gastric fundus. 2...
  24. ncbi Laparoscopic resection of submucosal tumor on posterior wall of gastric fundus
    Zhong Wei Ke
    Department of Minimally Invasive Surgery, Changhai Hospital, Second Military Medical University, 174 Changhai Road, Shanghai 200433, China
    World J Gastroenterol 10:2850-3. 2004
    Laparoscopic resection of tumors on the posterior wall of gastric fundus, especially when they are next to the esophagocardiac junction (ECJ), is both difficult and time-consuming...
  25. ncbi Nitric oxide modulates release of noradrenaline in guinea-pig gastric fundus
    E Sotirov
    Institute of Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria
    Brain Res Bull 51:401-5. 2000
    ..3)H]noradrenaline ([(3)H]NA) in conditions of non-activated and activated nicotinic receptors in guinea-pig gastric fundus preincubated with [(3)H]NA was studied...
  26. ncbi Cooling-induced contraction of the rat gastric fundus: mediation via transient receptor potential (TRP) cation channel TRPM8 receptor and Rho-kinase activation
    S Mustafa
    Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, Safat, Kuwait
    Clin Exp Pharmacol Physiol 32:832-8. 2005
    ..x 10(-6) and 3 x 10(-5) mol/L), a TRPM8 receptor antagonist, inhibited cooling-induced contraction of the rat gastric fundus. 4...
  27. pmc Interstitial cells of Cajal generate spontaneous transient depolarizations in the rat gastric fundus
    Yoshihiko Kito
    Department of Physiology, Nagoya City University Medical School, Mizuho ku, Nagoya, Japan
    Am J Physiol Gastrointest Liver Physiol 297:G814-24. 2009
    Intracellular recordings were made from isolated circular muscle bundles of rat gastric fundus. The majority of cells generated an ongoing discharge of electrical activity that were <or=10 mV in amplitude (unitary potentials)...
  28. ncbi Gastric fundus impression caused by a hepatic cyst mimicking gastric submucosal tumor
    Sung Soo Park
    South Med J 99:902-3. 2006
  29. ncbi Increased density of ghrelin-expressing cells in the gastric fundus and body in Prader-Willi syndrome
    Yon Ho Choe
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 IL Won Dong, Gang Nam Gu, Seoul, 135 710, Korea
    J Clin Endocrinol Metab 90:5441-5. 2005
    ..In this study, we hypothesized that the hyperghrelinemia observed in PWS is related to IGF-I or GH/IGF axis deficiency...
  30. ncbi Effect of cannabinoids on neural transmission in rat gastric fundus
    M Storr
    Department of Internal Medicine II, Technical University of Munich, Germany
    Can J Physiol Pharmacol 80:67-76. 2002
    The purpose of this study was to examine the possible role of cannabinoids on the neuromuscular function of rat gastric fundus. In addition to possible direct effects on smooth muscle, the influence of cannabinoids on contractile (..
  31. ncbi Impact of complete gastric fundus mobilization on outcome after laparoscopic total fundoplication
    A Blomqvist
    Department of Surgery, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden
    J Gastrointest Surg 4:493-500. 2000
    ..Dividing all short gastric vessels had no impact on the functional outcome during the first year of recovery after a total laparoscopic fundoplication...
  32. ncbi Gastric fundus tension before and after division of the short gastric vessels in a cadaveric model of fundoplication
    D J Szor
    Department of Surgery, Sao Paulo Medical School, Federal University of Sao Paulo, Brazil
    Dis Esophagus 22:539-42. 2009
    ..Some surgeons do not divide the SGV routinely to perform a fundoplication; however, excessive tension of the gastric fundus (GF) forces this procedure necessary in some cases...
  33. ncbi Okadaic acid inhibits relaxant neural transmission in rat gastric fundus in vitro
    M Storr
    Gap, Department of Internal Medicine II, Technical University of Munich, Ismaningerstr 22, Munich, Germany
    Acta Physiol Scand 175:29-36. 2002
    ..type 1 and 2A inhibitor okadaic acid on non-adrenergic, non-cholinergic (NANC) neurotransmission in the rat gastric fundus. Okadaic acid (10-6 M), an inhibitor of protein phosphatases 1 and 2A, did not show any influence on the basal ..
  34. ncbi Influence of motilin on gastric fundus tone and on meal-induced satiety in man: role of cholinergic pathways
    Rosario Cuomo
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 101:804-11. 2006
    ..It has been speculated that it is due to the contractile effect of motilin agonists on the proximal stomach, but the pathway involved and the symptomatic consequences have been incompletely elucidated...
  35. ncbi Reduced Shh expression in TFF2-overexpressing lesions of the gastric fundus under hypochlorhydric conditions
    Y Minegishi
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Pathol 213:161-9. 2007
    ..may be sufficient to down-regulate Shh expression in TFF2-overexpressing preneoplastic lesions of the gastric fundus. Since exposure to acid restored fundic Shh expression, appropriate gastric acid secretion may play an ..
  36. ncbi Investigation of a possible interaction between the heme oxygenase/biliverdin reductase and nitric oxide synthase pathway in murine gastric fundus and jejunum
    Ole De Backer
    Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium
    Eur J Pharmacol 590:369-76. 2008
    ..between the heme oxygenase (HO)/biliverdin reductase (BVR) and nitric oxide synthase (NOS) pathway in murine gastric fundus and jejunum, since previous studies have shown that both HO-2 and BVR are expressed in interstitial cells of ..
  37. ncbi Cortical deactivations during gastric fundus distension in health: visceral pain-specific response or attenuation of 'default mode' brain function? A H2 15O-PET study
    L Van Oudenhove
    Department of Neurosciences, Psychiatry Division, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Neurogastroenterol Motil 21:259-71. 2009
    ..To describe brain areas of decreased activity during gastric fundus distension compared to baseline, using data from our previously published study (Gastroenterology, 128, 2005 ..
  38. ncbi Anastomotic complications after Ivor Lewis esophagectomy in patients treated with neoadjuvant chemoradiation are related to radiation dose to the gastric fundus
    Caroline Vande Walle
    Department of Gastrointestinal Surgery, University Hospital, Ghent, Belgium
    Int J Radiat Oncol Biol Phys 82:e513-9. 2012
    ..Some studies have suggested that CRT results in increased surgical morbidity. We assessed the influence of CRT on anastomotic complications in a cohort of patients who underwent CRT followed by Ivor Lewis esophagectomy...
  39. ncbi Evidence for a modulatory role of orexin A on the nitrergic neurotransmission in the mouse gastric fundus
    Maria Caterina Baccari
    Department of Physiological Sciences, University of Florence, Florence, Italy
    Regul Pept 154:54-9. 2009
    ..of the present study was to investigate the effects of orexin A (OXA) on the relaxant responses of the mouse gastric fundus. Mechanical responses of gastric strips were recorded via force-displacement transducers...
  40. pmc Characterization of prostanoid receptors mediating contraction of the gastric fundus and ileum: studies using mice deficient in prostanoid receptors
    Y Okada
    Department of Pharmacology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
    Br J Pharmacol 131:745-55. 2000
    Receptors mediating prostanoid-induced contractions of longitudinal sections of gastric fundus and ileum were characterized by using tissues obtained from mice deficient in each type and subtype of prostanoid receptors...
  41. pmc Effects of some sterically hindered phenols on whole-cell Ca(2+) current of guinea-pig gastric fundus smooth muscle cells
    F Fusi
    Istituto di Scienze Farmacologiche, Universita degli Studi di Siena, via Piccolomini 170, 53100 Siena, Italy
    Br J Pharmacol 132:1326-32. 2001
    ..DIBHA), on the whole-cell Ca(2+) current (I(Ca)) of freshly isolated smooth muscle cells from the guinea-pig gastric fundus, in the presence of a range of Ca(2+) concentrations (1 -- 5 mM) using the patch-clamp technique...
  42. ncbi Distinct receptors for cholecystokinin and gastrin on canine fundic D-cells
    J Delvalle
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109
    Am J Physiol 264:G811-5. 1993
    ..These studies delineate the presence of distinct CCK-A and CCK-B/gastrin receptors on canine fundic D-cells.(ABSTRACT TRUNCATED AT 250 WORDS)..
  43. ncbi Relaxant effect of capsaicin in the rat gastric fundus
    R A Lefebvre
    Heymans Institute of Pharmacology, University of Gent Medical School, Belgium
    Eur J Pharmacol 195:131-7. 1991
    The effect of capsaicin was studied in precontracted longitudinal muscle strips of the rat gastric fundus. Capsaicin induced a relaxation in the concentration range 10(-7)-10(-6) M...
  44. ncbi Amylin, released from the gastric fundus, stimulates somatostatin and thus inhibits histamine and acid secretion in mice
    Muhammad Zaki
    Department of Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
    Gastroenterology 123:247-55. 2002
    ..with calcitonin gene-related peptide (CGRP), is colocalized with somatostatin in endocrine cells of the gastric fundus. The present study was designed to determine the mechanism of action of amylin on gastric exocrine and ..
  45. ncbi Sodium nitroprusside-induced rat fundus relaxation is ryanodine-sensitive and involves L-type Ca2+ channel and small conductance Ca(2+)-sensitive K+ channel components
    J Geeson
    School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 5XH, UK
    Auton Autacoid Pharmacol 22:297-301. 2002
    ..6 These data suggest that SNP-mediated fundus relaxation occurs via a cGMP-mediated and ryanodine-sensitive mechanism which requires, at least in part, SKCa and L-type Ca2+ channel activity...
  46. ncbi Differential regulation of rat peripheral 5-HT(2A) and 5-HT(2B) receptor systems: influence of drug treatment
    M J Enguix
    School of Pharmacy, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain
    Naunyn Schmiedebergs Arch Pharmacol 368:79-90. 2003
    ..The in vitro contractile response elicited by serotonin (5-HT, 10 micro M) in the rat gastric fundus (5-HT(2B) receptor system) was rapid and followed by a partial fade to a steady state, in contrast with the ..
  47. ncbi Effects of alpha-lipoic acid on impaired gastric fundus innervation in diabetic rats
    T Michael Gibson
    Department of Biomedical Sciences, University of Aberdeen, Aberdeen, Scotland, United Kingdom
    Free Radic Biol Med 35:160-8. 2003
    ..with the antioxidant, alpha-lipoic acid (LA), could prevent or correct diabetic functional defects in the gastric fundus non-adrenergic, non-cholinergic (NANC) nerves, which use nitric oxide as their major neurotransmitter...
  48. ncbi Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus
    Kansu Buyukafsar
    Department of Pharmacology, Medical Faculty, Mersin University Campus, Yenisehir, Mersin 33169
    Biochem Biophys Res Commun 303:777-81. 2003
    ..35+/-0.06 M (p<0.001), respectively. Moreover, [3H]acetylcholine ([3H]ACh) release upon EFS from the gastric fundus was measured and it was found that Y-27632 (10(-4)M) significantly impaired the release...
  49. ncbi [Endoscopic ultrasound in routine clinical practice for staging adenocarcinomas of the stomach and distal esophagus]
    N Bösing
    Klinik für Allgemein und Unfallchirurgie, Klinikum der Heinrich Heine Universität, Dusseldorf
    Chirurg 74:214-21; discussion 222-3. 2003
    ..Endoscopic ultrasound (EUS) is an important diagnostic tool for determining the best therapeutic strategy (primary resection, neoadjuvant therapy or palliation only) to offer esophageal or gastric cancer patients...
  50. ncbi Gastric atrial natriuretic peptide regulates endocrine secretion in antrum and fundus of human and rat stomach
    W R Gower
    Department of Surgery, University of South Florida, Tampa, Florida 33612, USA
    Am J Physiol Gastrointest Liver Physiol 284:G638-45. 2003
    ..Stimulation of somatostatin secretion is coupled to inhibition of gastrin secretion in the antrum and inhibition of histamine secretion in the fundus...
  51. ncbi A pharmacological analysis of the contractile effects of glutamate on rat and human isolated gut smooth muscle strips
    D R Milovanovic
    Department of Pharmacology, Medical Faculty, University of Kragujevac, Kragujevac, Serbia, Yugoslavia
    Methods Find Exp Clin Pharmacol 24:661-8. 2002
    ..AMPA, quisqualate, cis-ACPD and (2R,4R)-APDC evoked concentration-dependent contraction of isolated adult rat gastric fundus, with EC50 values of 210 microM, 150 microM, 20 microM, 33 microM, and 2.7 microM and 7.9 microM, respectively...
  52. ncbi Pharmacological characterization of a novel antiglaucoma agent, Bimatoprost (AGN 192024)
    D F Woodward
    Department of Biological Sciences, Allergan, Inc, 2525 Dupont Dr, Irvine, CA 92612, USA
    J Pharmacol Exp Ther 305:772-85. 2003
    ..Bimatoprost was overwhelmingly the predominant molecular species identified at all time points in ocular tissues, indicating that the intact molecule reduces intraocular pressure...
  53. ncbi Topographic association of gastric epithelial expression of Ki-67, Bax, and Bcl-2 with antralization in the gastric incisura, body, and fundus
    Harry Hua Xiang Xia
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Am J Gastroenterol 97:3023-31. 2002
    ..The aim of this study was to determine the topographic associations of Ki-67 (a protein expressed in proliferative cells), Bax (a pro-apoptotic protein), and Bcl-2 (an antiapoptotic protein) expression with antralization...
  54. pmc Isolation and primary structure of pituitary human galanin, a 30-residue nonamidated neuropeptide
    W E Schmidt
    Department of Medicine, Georg August University of Gottingen, Federal Republic of Germany
    Proc Natl Acad Sci U S A 88:11435-9. 1991
    ..Synthetic hGal possesses full biological activity on isolated rat fundus muscle strips...
  55. pmc RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction
    Paul H Ratz
    Department of Physiological Sciences, Eastern Virginia Medical School, PO Box 1980, Norfolk, Virginia, VA 23501, USA
    Br J Pharmacol 137:983-92. 2002
    ....
  56. ncbi Functional roles of muscarinic M2 and M3 receptors in mouse stomach motility: studies with muscarinic receptor knockout mice
    Takio Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Eur J Pharmacol 554:212-22. 2007
    ....
  57. pmc Impact of Helicobacter pylori infection and mucosal atrophy on gastric lesions in patients with familial adenomatous polyposis
    S Nakamura
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Gut 51:485-9. 2002
    ..The role of Helicobacter pylori and atrophic gastritis in the pathogenesis of gastric lesions in familial adenomatous polyposis (FAP) has not been clarified...
  58. ncbi Effect of phorbol 12,13-dibutyrate on smooth muscle tone in rat stomach fundus
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    J Smooth Muscle Res 41:107-16. 2005
    ..We speculate that a major factor mediating the relaxant action of PDBu in rat stomach fundus smooth muscle is represented by a reduction in Ca2+ influx via an inhibition of Ca2+ channels...
  59. ncbi Pharmacological characterization of 5-Hydroxytryptamine-receptor subtypes in circular muscle from the rat stomach
    Tohru Komada
    Discovery Biology Research, Global Research and Development, Nagoya Laboratories, Pfizer Japan Inc, 5 2 Taketoyo, Aichi 470 2393, Japan
    Biol Pharm Bull 30:508-13. 2007
    ..The corpus presents the contractile 5-HT2A receptors, and the fundus presents the contractile 5-HT2B receptors and the relaxant 5-HT2A and 5-HT4 receptors...
  60. ncbi Vasoactive intestinal peptide receptor subtypes and signalling pathways involved in relaxation of human stomach
    C Severi
    Department of Clinical Sciences, University La Sapienza, Rome, Italy
    Neurogastroenterol Motil 18:1009-18. 2006
    ..In conclusion, regional differences in VIP action on human stomach are related to distinct myogenic properties of SMC of the antrum and the fundus...
  61. ncbi Treatment of morbid obesity by intraparietogastric administration of botulinum toxin: a randomized, double-blind, controlled study
    D Foschi
    I Unit of Surgery, Department of Clinical Sciences L Sacco, San Siro Clinical Institute, University of Milan, Milan, Italy
    Int J Obes (Lond) 31:707-12. 2007
    ..The aim of our study was to investigate whether or not the intraparietogastric administration of botulinum toxin A (BTX), able to modify the motility patterns of the stomach, could be useful for treatment of obesity...
  62. ncbi Diabetes-related changes in contractile responses of stomach fundus to endothelin-1 in streptozotocin-induced diabetic rats
    Kazuki Endo
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    J Smooth Muscle Res 41:35-47. 2005
    ..These results suggest that the diabetes-related enhancement of the ET-1-induced contraction of the stomach fundus may be due to an increase in the ET(B) receptor population...
  63. ncbi Coexistence of gastric- and intestinal-type endocrine cells in gastric and intestinal mixed intestinal metaplasia of the human stomach
    Takafumi Otsuka
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Pathol Int 55:170-9. 2005
    ....
  64. ncbi Effect of an aqueous distillate of Origanum onites L. on isolated rat fundus, duodenum and ileum: evidence for the role of oxygenated monoterpenes
    S Aydin
    Department of Pharmacology, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey
    Pharmazie 60:147-50. 2005
    ..As being one of the first pharmacological studies on aqueous distillates, a possible pharmacological activity of cis-p-menth-4-ene-1,2-diol and 3,7-dimethyl-1-octen-3,7-diol is proposed in this study...
  65. ncbi Effects of the selective serotonin reuptake inhibitor, fluoxetine, on regional gastric contractility
    A N James
    Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Neurogastroenterol Motil 17:76-82. 2005
    ..Selective serotonin reuptake inhibitors (SSRIs) are increasingly used to treat a variety of disorders but have gastrointestinal side-effects...
  66. pmc The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo
    D T Beattie
    Theravance, Inc, 901 Gateway Boulevard, South San Francisco, CA 94080, USA
    Br J Pharmacol 143:549-60. 2004
    ..It remains to be determined whether this 5-HT2B receptor antagonist activity of tegaserod contributes to its clinical profile...
  67. ncbi Roles of CaM kinase II and phospholamban in SNP-induced relaxation of murine gastric fundus smooth muscles
    Minkyung Kim
    Dept of Physiology and Cell Biology, Univ of Nevada School of Medicine, Anderson Bldg MS352, Reno, NV 89557, USA
    Am J Physiol Cell Physiol 291:C337-47. 2006
    ..Our findings that caffeine relaxes and hyperpolarizes murine gastric fundus smooth muscles and increases phospholamban (PLB) phosphorylation by Ca2+/calmodulin (CaM)-dependent protein ..
  68. ncbi Histology and culture results among subjects with antibodies to CagA but no evidence of Helicobacter pylori infection with IgG ELISA
    Weimin Ye
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Scand J Gastroenterol 40:312-8. 2005
    ..In a recent case-control study, this serological pattern was strongly linked to stomach cancer, and it was hypothesized to represent "burned-out" CagA-positive infections. The aim of this analysis was to test this hypothesis...
  69. ncbi Effects of EGIS-7625, a selective and competitive 5-HT2B receptor antagonist
    Anikó Kovács
    Division of Preclinical Research, EGIS Pharmaceuticals Ltd, Budapest, Hungary
    Cardiovasc Drugs Ther 17:427-34. 2003
    ..In conclusion, EGIS-7625 is a potent, selective and competitive 5-HT(2B) antagonist that seems to be a good research tool for the separation of the functional roles of vascular 5-HT(2A) and 5-HT(2B) receptors...
  70. ncbi [Gastric epithelial polyps (part two)]
    Luis Hernán Espejo Romero
    Clínica Médica de la UNMSM, and Propedéutica y Clínica de la Universidad San Martín de Porres
    Rev Gastroenterol Peru 24:50-74. 2004
    ..97 mEql for hyperplastics and 1.60 mEql for adenomas. D.A.M. was 6.05 mEql for hyperplastics and 5.49 mEql for adenomas. Our experience as to normal cases showed 2.5 mEqh +/- 1.2 and 22 mEqh +/- 6, respectively, for D.A.B and D.A.M...
  71. ncbi Nitrergic relaxation in rat gastric fundus: influence of mechanism of induced tone and possible role of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase
    Lieve A Van Geldre
    Heymans Institute of Pharmacology, Ghent University, De Pintelaan 185, B 9000 Gent, Belgium
    Life Sci 74:3259-74. 2004
    ..tone and the role of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) in nitrergic relaxation of rat gastric fundus. Prostaglandin F(2alpha) (PGF(2alpha)), thapsigargin (TSG) and cyclopiazonic acid (CPA) were used in ..
  72. ncbi Impaired gastric motility in the gastroesophageal reflux rat model: an in vitro study
    Melih Tugay
    Department of Pediatric Surgery, Kocaeli University, Medical School, Kocaeli, Turkey
    J Surg Res 115:272-8. 2003
    ..The present study investigated the effects of acid and mixed reflux on the responsiveness of gastric smooth muscle in the gastroesophageal reflux (GER) rat model...
  73. ncbi Differential effects of nifedipine and verapamil on non-adrenergic non-cholinergic relaxations at different levels of active tone: assessment of the contribution of nerve-derived hyperpolarizing factor
    Y Ergun
    Department of Pharmacology, Faculty of Medicine, University of Cukurova, 01330, Balcali, Adana, Turkey
    Auton Autacoid Pharmacol 25:105-12. 2005
    ..non-adrenergic non-cholinergic (NANC) nerve-mediated relaxations in different states of active tone in the rat gastric fundus. 2. NANC relaxations induced by electrical field stimulation (ES: 0.1, 0...
  74. ncbi Gastric smooth muscle contractility changes in the esophageal atresia rat model: an in vitro study
    Melih Tugay
    Kocaeli University, Istanbul, Turkey
    J Pediatr Surg 38:1366-70. 2003
    ..The aim of the study was to investigate the gastric smooth muscle reactivity in the Adriamycin-induced esophageal atresia (EA) rat model...
  75. ncbi Influence of the selective neuronal NO synthase inhibitor ARL 17477 on nitrergic neurotransmission in porcine stomach
    Romain A Lefebvre
    Heymans Institute of Pharmacology, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, B 9000 Gent, Belgium
    Eur J Pharmacol 525:143-9. 2005
    ..of the selective nNOS inhibitor ARL 17477 was studied on electrically induced nitrergic relaxations in pig gastric fundus strips and on gastric fundic compliance in conscious pig...
  76. ncbi Depression by relaxin of neurally induced contractile responses in the mouse gastric fundus
    Maria Caterina Baccari
    Departments of Physiological Sciences and Anatomy, 4, University of Florence, Florence, Italy
    Biol Reprod 70:222-8. 2004
    ..In conclusion, the peptide hormone relaxin depresses cholinergic contractile responses in the mouse gastric fundus by up-regulating NO biosynthesis at the neural level.
  77. ncbi Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro
    Inge Depoortere
    Centre for Gastroenterological Research, Department of Pathophysiology, University of Leuven, Gasthuisberg O and N, B 3000, Leuven, Belgium
    Eur J Pharmacol 515:160-8. 2005
    ..We compared the gastroprokinetic effects of ghrelin, the ghrelin receptor agonist, growth hormone releasing peptide 6 (GHRP-6), and motilin in rats in vivo and in vitro...
  78. pmc Characterization of pre- and postsynaptic muscarinic receptors in circular muscle of pig gastric fundus
    Pascal G Leclere
    Heymans Institute of Pharmacology, Ghent University, Faculty of Medicine and Health Sciences, De Pintelaan 185, B 9000 Ghent, Belgium
    Br J Pharmacol 135:1245-54. 2002
    ..of muscarinic receptors on the cholinergic neurones and smooth muscle in the circular muscle of the pig gastric fundus. 2...
  79. ncbi Comparative inhibitory effects of niflumic acid and novel synthetic derivatives on the rat isolated stomach fundus
    David N Criddle
    Departamento de Ciencias Fisiologicas, CCS, Universidade Estadual do Ceara, Fortaleza, Brazil
    J Pharm Pharmacol 54:283-8. 2002
    ....
  80. ncbi Antispasmodic, bronchodilator and vasodilator activities of (+)-catechin, a naturally occurring flavonoid
    Muhammad Nabeel Ghayur
    Natural Product Research Lab, Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi, Pakistan
    Arch Pharm Res 30:970-5. 2007
    ....
  81. ncbi Nitric oxide involvement in the effect of acute lithium administration on the nonadrenergic noncholinergic-mediated relaxation of rat gastric fundus
    Mehdi Ghasemi
    Department of Pharmacology, School of Medicine, Medical Sciences University of Tehran, Tehran 13145 784, Iran
    Nitric Oxide 17:152-9. 2007
    ..of the present study was to verify the effect of acute lithium administration on the nonadrenergic noncholinergic (NANC)-mediated relaxation of rat isolated gastric fundus and to evaluate the role of nitric oxide pathway in this manner.
  82. ncbi Difference of p53AIP1 mRNA expression in gastric mucosa between patients with gastric cancer and chronic gastritis infected with Helicobacter pylori
    Manabu Sawaya
    First Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Japan
    J Clin Gastroenterol 42:351-5. 2008
    ..To examine the significance of alteration of p53-regulated apoptosis-induced protein 1 (p53AIP1) expression in gastric carcinogenesis in patients with Helicobacter pylori infection...
  83. ncbi Functional association between proximal and distal gastric motility during fasting and duodenal nutrient stimulation in humans
    N Q Nguyen
    Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, SA 5000, Australia
    Neurogastroenterol Motil 19:638-45. 2007
    ..In humans, a functional association exists between proximal and distal gastric motility during fasting and duodenal nutrient stimulation. This may have a role in optimizing intra-gastric meal distribution...
  84. ncbi Gene expression profiling in human gastric mucosa infected with Helicobacter pylori
    Véronique J Hofman
    Faculty of Medicine, Inserm ERI 21, Nice Cedex, France
    Mod Pathol 20:974-89. 2007
    ..This study provides 'proof-of-principle' data for identifying molecular mechanisms driving H. pylori-associated carcinogenesis before morphological evidence of changes along the neoplastic progression pathway...
  85. ncbi Effects of trout endothelin on the motility of gastrointestinal smooth muscle from the trout and rat
    Y Wang
    Department of Biomedical Sciences, Creighton University Medical School, Omaha, Nebraska 68178, USA
    Gen Comp Endocrinol 123:156-62. 2001
    ..The rat ET-1-induced contractions of the trout gastrointestinal tissues are in part indirect, involving a serotoninergic neuronal pathway in the intestine and a noncholinergic, nonserotoninergic pathway in the stomach...
  86. ncbi Effects of washout following indomethacin administration on electrical field stimulation-induced isolated rat gastric fundus strip contractions
    Mansoor Keshavarz
    Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    J Gastroenterol Hepatol 22:1456-9. 2007
    ..action of indomethacin, the drug has shown relaxatory effects on isolated longitudinal and transverse rat gastric fundus. To explain the above discrepancy, the aim of this study was to investigate the effects of washout following ..
  87. ncbi The 5-HT2B antagonist and 5-HT4 agonist activities of tegaserod in the anaesthetized rat
    J L McCullough
    Department of Pharmacology, Theravance Inc, 901 Gateway Boulevard, South San Francisco, CA 94080, USA
    Pharmacol Res 53:353-8. 2006
    ..The clinical relevance of the 5-HT2B receptor antagonism of tegaserod remains to be determined...
  88. ncbi Catecholaminergic neurons in rat dorsal motor nucleus of vagus project selectively to gastric corpus
    J J Guo
    Neurogastroenterology Research, Henry Ford Health System, Detroit, Michigan 48202, USA
    Am J Physiol Gastrointest Liver Physiol 280:G361-7. 2001
    ..NOS-IR) neurons in the rat caudal dorsal motor nucleus of the vagus (DMV) project selectively to the gastric fundus and may be involved in vagal reflexes controlling gastric distension...
  89. pmc Pre- and postjunctional protective effect of neocuproine on the nitrergic neurotransmitter in the mouse gastric fundus
    J G de Man
    Division of Gastroenterology, Faculty of Medical and Pharmaceutical Sciences, University of Antwerp (UIA, B-2610 Antwerpen, Belgium
    Br J Pharmacol 132:277-85. 2001
    1. Electrical field stimulation (EFS) of non-adrenergic non-cholinergic nerves of the mouse gastric fundus induced frequency-dependent transient relaxations which were mimicked by nitric oxide (NO), added as acidified NaNO(2)...
  90. ncbi Influence of orexin A on the mechanical activity of mouse gastric strips
    Maria Caterina Baccari
    Department of Physiological Sciences, University of Florence, Viale G B Morgagni 63, 50134, Florence, Italy
    Regul Pept 146:67-72. 2008
    ..The results indicate that OXA exerts region-specific effects and that, in the fundus, depresses EFS-induced contractile responses by acting at the nervous level. It is likely that NO is involved in the effects of the peptide...
  91. ncbi Deficiency of intramuscular ICC increases fundic muscle excitability but does not impede nitrergic innervation
    Jan D Huizinga
    Intestinal Disease Research Program, Department of Medicine, McMaster University, Hamilton, ON, L8N 3Z5, Canada
    Am J Physiol Gastrointest Liver Physiol 294:G589-94. 2008
    ..The fundic musculature shows increased responses to substance P-mediated innervation and shows marked spontaneous activity, which is consistent with increased muscle excitability...
  92. ncbi Smooth muscle myosin heavy chain isoform distribution in the swine stomach
    Jonathan A Parisi
    Marquette University, Department of Biology, Milwaukee, Wisconsin 53201 1881, USA
    J Histochem Cytochem 50:385-93. 2002
    ..This information may prove useful in helping to elucidate possible unique physiological roles of SMB MHC...
  93. ncbi Impaired nitrergic relaxations in the gastric fundus of dystrophic (mdx) mice
    M C Baccari
    Department of Physiology, University of Florence, Viale G B Morgagni 63, 50134, Florence, Italy
    Neurosci Lett 282:105-8. 2000
    ..Results suggest that, in strips from mdx mice, a defective production/release of the neurotransmitter responsible for the brisk relaxation, likely nitric oxide, occurs...
  94. ncbi An unusual expression of hyperplastic gastropathy (Menetrier type) in twins
    Carolina Ibarrola
    Department of Pathology, Hospital 12 de Octubre, Madrid, Spain
    Eur J Gastroenterol Hepatol 15:441-5. 2003
    ..Their stomachs showed confluent polypoid mucosal projections affecting mainly the gastric fundus and the antrum...
  95. ncbi Inhibitory actions of indomethacin on electrical and mechanical responses produced by nerve stimulation in circular smooth muscle of the guinea-pig gastric fundus
    S Yoneda
    Department of Physiology, Nagoya City University Medical School, Nagoya, Japan
    J Smooth Muscle Res 37:81-93. 2001
    ..by transmural nerve stimulation (TNS) were investigated in isolated circular smooth muscle of the guinea-pig gastric fundus. TNS evoked a cholinergic excitatory junction potential (e.j.p.). The e.j.p...
  96. ncbi Nitrergic and purinergic interplay in inhibitory transmission in rat gastric fundus
    T Vetri
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita degli Studi di Palermo, Viale delle Scienze, Parco D Orleans II, Palermo, Italy
    Auton Autacoid Pharmacol 27:151-7. 2007
    ..non- cholinergic (NANC) relaxation and possible interplay between nitrergic and purinergic systems in rat gastric fundus. 2 Experiments were performed in vitro on strips of longitudinal muscle from rat gastric fundus, recording the ..
  97. pmc Autoregulation of enterochromaffin-like cell histamine secretion via the histamine 3 receptor subtype
    M Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520-8062, USA
    Yale J Biol Med 69:9-19. 1996
    INTRODUCTION: The neuroendocrine histamine-secreting cell of the gastric fundus, the enferochromaffin-like cell, is the principal regulator of parietal cell acid secretion...
  98. ncbi The gastric biology of Helicobacter pylori
    George Sachs
    Department of Physiology, University of California, Los Angeles, California 90024, USA
    Annu Rev Physiol 65:349-69. 2003
    ..This allows the organism to live in either gastric fundus or gastric antrum depending on the level of acidity at the gastric surface...
  99. pmc Effects of omega-conotoxin GVIA on autonomic neuroeffector transmission in various tissues
    A De Luca
    Department of Pharmacology, University of Melbourne, Victoria, Australia
    Br J Pharmacol 101:437-47. 1990
    ..in response to field stimulation of NANC nerves were inhibited by conotoxin in guinea-pig taenia caeci and rat gastric fundus strips, and in rat anococcygeus muscle when the tone was raised by guanethidine but not when it was raised by ..
  100. ncbi [Antireflux surgery, comperative study of three laparascopic techniques]
    Xavier Gómez Cárdenas
    Departamento de Cirugia General, Centro Medico ABC, Mexico, D F
    Rev Gastroenterol Mex 70:402-10. 2005
    ..Laparoscopic fundoplication for the surgical treatment of gastroesophageal reflux disease is widely accepted all over the world...
  101. pmc Purinoceptors mediating relaxation and spasm in the rat gastric fundus
    M S Matharu
    Department of Physiological Sciences, Medical School, Manchester University
    Br J Pharmacol 106:395-403. 1992
    1. The relaxant and spasmogenic effects of purines and analogues were studied in longitudinal strips of rat gastric fundus to characterize the purinoceptors involved...

Research Grants24

  1. Oxyntic Atrophy and Novel Gastric Lineages
    JAMES RICHARD GOLDENRING; Fiscal Year: 2013
    ..Furthermore, we will examine whether Lgr5-expressing chief cells in the gastric fundus may represent a quiescent progenitor cell population that could contribute to the development of SPEM...
  2. Image-guided Bariatric Arterial Embolization (BAE) for the Treatment of Obesity
    CLIFFORD RAABE WEISS; Fiscal Year: 2013
    ..A potent endogenous hunger stimulant, ghrelin, which is principally produced in the gastric fundus, has been a target for weight loss...
  3. PROSTAGLANDINS AND LOCAL CONTROL OF THE CIRCULATION
    ALAN NIES; Fiscal Year: 1990
    ..For gastric studies, a canine model with isolation of the circulation of the gastric fundus and corpus will be used so that substances inducing or blocking histamine release can be studied without ..
  4. H+ NEUTRALIZATION AND C1- HOMEOSTASIS IN GASTRIC MUCOSA
    David Soybel; Fiscal Year: 2002
    ..cotransporter is the dominant mechanism for regulating aiCl of oxyntic cells and surface cells in Necturus gastric fundus during stimulation of acid secretion; 2) a complementary, Cl--independent mechanism of basolateral HCO3-..
  5. ELECTROPHYSIOLOGY OF GASTRIC ION TRANSPORT
    JEFFREY DEMAREST; Fiscal Year: 1991
    ..mechanisms which oxyntic (OC, acid-secreting) and surface epithelial (SEC, mucus- secreting) cells of the gastric fundus use to actively transport H, Cl, Na and HC03: and (ii) characterize the properties of the paracellular shunt...
  6. VAGAL GASTRIC MOTOR CONTROL IN MICE
    ELITA PARTOSEOEDARSO; Fiscal Year: 2002
    ..In the hindbrain, vagal motor output to the gastric fundus is from preganglionic cholinergic neurons that are both excitatory and inhibitory...
  7. ELECTRICAL CONTROL OF GASTRODUODENAL MOTILITY
    KENTON SANDERS; Fiscal Year: 2003
    ..This information will be useful in designing rational therapies for patients that suffer from problems resulting from inappropriate gastric emptying. ..
  8. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 2009
    ..pylori pathogenesis and specifically evaluate the role of regulatory T cells in limiting H. pylori-induced gastric pathology. ..
  9. HUS Pathogenesis & clinical Outcome in an in vivo model
    James Fox; Fiscal Year: 2008
    ..We will use this model to study the pathogenesis of HUS and importantly to develop therapeutic regimens to prevent and treat EHEC disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  10. GASTRIC ENTEROCHROMAFFIN-LIKE CELL IN ULCER DISEASE
    George Sachs; Fiscal Year: 2005
    ..Hence this approach will provide additional insights into mechanisms of regulation of gastric secretion and enable illuminated interpretation of the pathophysiology of peptic ulcer disease. ..
  11. INCREASING COLORECTAL CANCER SCREENING
    Randall Burt; Fiscal Year: 2005
    ..abstract_text> ..
  12. Zeiss LSM 510 Laser Scanning Confocal Microscope
    Sean Ward; Fiscal Year: 2002
    ..The instrument will be housed in an existing NIH funded imaging core laboratory. ..
  13. PHENOTYPIC AND PSYCHOSOCIAL STUDY OF THE L1307K MUTATION
    Henry Lynch; Fiscal Year: 2004
    ....
  14. Microecology-murine gut-initiation & progression of IBD
    James Fox; Fiscal Year: 2005
    ..prior and subsequent to oral vaccination with Helicobacter spp. antigens and mucosal adjuvants, elucidate how these vaccine strategies influence microflora dynamics and impact gut cytokine responses. ..
  15. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    James Fox; Fiscal Year: 2006
    ....
  16. HIGH RISK FAMILIAL COLON CANCER- GENETICS AND PHENOTYPE
    Randall Burt; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  17. THE GASTRIC ACID PUMP AS A TARGET FOR ULCER TREATMENT
    George Sachs; Fiscal Year: 2009
    ..The results of the proposed research will further improve the agents used for the treatment of acid-related diseases and also our knowledge of the ATPase and cellular events involved in regulation of its activity. ..
  18. Helicobacter induced hepatitis and tumorigenesis
    James Fox; Fiscal Year: 2009
    ..A more complete understanding of the etiopathogenesis of hepatobiliary disease and hepatocellular carcinoma is likely to result in new strategies for treatment and prevention of these important human diseases. ..
  19. Hindbrain Actions of Leptin
    Gerlinda E Hermann; Fiscal Year: 2011
    ..Clearly, a better understanding of the control of energy expenditure should be crucial to the control of obesity and is of critical scientific, clinical and societal importance. ..
  20. Thrombin and CNS: Gastric Dysfunction after Head Trauma
    Gerlinda Hermann; Fiscal Year: 2006
    ..e., via an R01 funding program). ..
  21. Alternative Estrogen Replacement Therapy for Colon Canc*
    Martha Campbell Thompson; Fiscal Year: 2004
    ..These results would also suggest additional potential for chemoprevention strategies based on selective estrogen receptor (ERbeta) therapies. ..