stomach

Summary

Summary: An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.

Top Publications

  1. ncbi Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    M Kojima
    Department of Biochemistry, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Nature 402:656-60. 1999
  2. pmc Helicobacter pylori persistence: biology and disease
    Martin J Blaser
    Department of Medicine, New York University School of Medicine, and New York Harbor Veterans Affairs Medical Center, New York 10016, USA
    J Clin Invest 113:321-33. 2004
  3. doi Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro
    Nick Barker
    Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht and University Medical Centre Utrecht, Netherlands
    Cell Stem Cell 6:25-36. 2010
  4. ncbi Overexpression of heat shock protein 70 in stomach of stress-induced gastric ulcer-resistant rats
    Kazuko Shichijo
    Department of Molecular Pathology and Radiation Biophysics, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Department of Pathology, Nagasaki Medical Center, Japan
    Dig Dis Sci 48:340-8. 2003
  5. doi Remote magnetic manipulation of a wireless capsule endoscope in the esophagus and stomach of humans (with videos)
    Paul Swain
    Department of Biosurgery and Surgical Technology, Imperial College and London University, 41 Willow Road, London, NW3 1TN United Kingdom
    Gastrointest Endosc 71:1290-3. 2010
  6. pmc Peptidoglycan crosslinking relaxation promotes Helicobacter pylori's helical shape and stomach colonization
    Laura K Sycuro
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
    Cell 141:822-33. 2010
  7. ncbi Anthocyanins are efficiently absorbed from the stomach in anesthetized rats
    Severine Talavera
    Laboratoire de Pharmacognosie, Faculte de Pharmacie, 63001 Clermont Ferrand, France
    J Nutr 133:4178-82. 2003
  8. pmc Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori
    Nina R Salama
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3 168, Seattle, Washington 981091024, USA
    Nat Rev Microbiol 11:385-99. 2013
  9. pmc Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium
    Daniel E Stange
    Hubrecht Institute for Developmental Biology and Stem Cell Research and University Medical Centre Utrecht, 3584 CT Utrecht, the Netherlands Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, University of Dresden, 01307 Dresden, Germany
    Cell 155:357-68. 2013
  10. pmc Ultra-deep sequencing reveals the microRNA expression pattern of the human stomach
    Andrea Ribeiro-Dos-Santos
    Instituto de Ciencias Biologicas, Universidade Federal do Para, Belem, Brazil
    PLoS ONE 5:e13205. 2010

Detail Information

Publications352 found, 100 shown here

  1. ncbi Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    M Kojima
    Department of Biochemistry, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Nature 402:656-60. 1999
    ..We now report the purification and identification in rat stomach of an endogenous ligand specific for GHS-R...
  2. pmc Helicobacter pylori persistence: biology and disease
    Martin J Blaser
    Department of Medicine, New York University School of Medicine, and New York Harbor Veterans Affairs Medical Center, New York 10016, USA
    J Clin Invest 113:321-33. 2004
    ..bacteria that have coevolved with humans to be transmitted from person to person and to persistently colonize the stomach. Their population structure is a model for the ecology of the indigenous microbiota...
  3. doi Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro
    Nick Barker
    Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht and University Medical Centre Utrecht, Netherlands
    Cell Stem Cell 6:25-36. 2010
    ..Here, we investigated Lgr5 expression in the stomach and assessed the stem cell potential of the Lgr5(+ve) cells by using in vivo lineage tracing...
  4. ncbi Overexpression of heat shock protein 70 in stomach of stress-induced gastric ulcer-resistant rats
    Kazuko Shichijo
    Department of Molecular Pathology and Radiation Biophysics, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Department of Pathology, Nagasaki Medical Center, Japan
    Dig Dis Sci 48:340-8. 2003
    ..Our results indicate that overexpression of heat shock protein 70 in the stomach seems to protect against gastric ulcers through its cytoprotective effects on gastric mucosa by increasing ..
  5. doi Remote magnetic manipulation of a wireless capsule endoscope in the esophagus and stomach of humans (with videos)
    Paul Swain
    Department of Biosurgery and Surgical Technology, Imperial College and London University, 41 Willow Road, London, NW3 1TN United Kingdom
    Gastrointest Endosc 71:1290-3. 2010
    ..Remote manipulation of wireless capsule endoscopes might improve diagnostic accuracy and facilitate therapy...
  6. pmc Peptidoglycan crosslinking relaxation promotes Helicobacter pylori's helical shape and stomach colonization
    Laura K Sycuro
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
    Cell 141:822-33. 2010
    ..This pathway is required for robust colonization of the stomach in spite of normal directional motility...
  7. ncbi Anthocyanins are efficiently absorbed from the stomach in anesthetized rats
    Severine Talavera
    Laboratoire de Pharmacognosie, Faculte de Pharmacie, 63001 Clermont Ferrand, France
    J Nutr 133:4178-82. 2003
    ..The aim of this study was to evaluate the fate of anthocyanins in the stomach. Absorption of purified anthocyanins (14 micromol/L) as well as blackberry 14 and 750 micromol/L) and bilberry (..
  8. pmc Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori
    Nina R Salama
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3 168, Seattle, Washington 981091024, USA
    Nat Rev Microbiol 11:385-99. 2013
    ..We also describe the immunobiology of H. pylori infection and highlight how this bacterium manipulates the innate and adaptive immune systems of the host to promote its own persistence...
  9. pmc Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium
    Daniel E Stange
    Hubrecht Institute for Developmental Biology and Stem Cell Research and University Medical Centre Utrecht, 3584 CT Utrecht, the Netherlands Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, University of Dresden, 01307 Dresden, Germany
    Cell 155:357-68. 2013
    ..These observations challenge the notion that stem cell hierarchies represent a "one-way street." ..
  10. pmc Ultra-deep sequencing reveals the microRNA expression pattern of the human stomach
    Andrea Ribeiro-Dos-Santos
    Instituto de Ciencias Biologicas, Universidade Federal do Para, Belem, Brazil
    PLoS ONE 5:e13205. 2010
    ..roles in tissue differentiation and in maintaining basal physiology, little is known about the miRNA expression levels in stomach tissue. Alterations in the miRNA profile can lead to cell deregulation, which can induce neoplasia.
  11. doi Survival in hostile territory: the microbiota of the stomach
    Ines Yang
    Hannover Medical School, Institute of Medical Microbiology and Hospital Epidemiology, Hannover, Germany
    FEMS Microbiol Rev 37:736-61. 2013
    The human stomach is a formidable barrier to orally ingested microorganisms and was long thought to be sterile...
  12. doi Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells
    Luan Wen
    Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, 510663 Guangzhou, China
    Dev Dyn 239:2198-207. 2010
    ..showing characteristic expression in the central nervous system as well as in the pancreas and part of the stomach/duodenum (SD) at tadpole stages of development...
  13. ncbi Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration
    K Toshinai
    Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, 889 1692, Japan
    Biochem Biophys Res Commun 281:1220-5. 2001
    ..Ghrelin-producing cells are most abundant in the oxyntic glands of the stomach. The regulatory mechanism that governs the biosynthesis and secretion of ghrelin has not been clarified...
  14. ncbi Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans
    H Ariyasu
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
    J Clin Endocrinol Metab 86:4753-8. 2001
    Ghrelin, an endogenous ligand for the GH secretagogue receptor, was isolated from rat stomach and is involved in a novel system for regulating GH release...
  15. pmc The origin of pre-neoplastic metaplasia in the stomach: chief cells emerge from the Mist
    James R Goldenring
    Nashville Department of Veterans Affairs Medical Center, Nashville, TN, USA
    Exp Cell Res 317:2759-64. 2011
    ..Here, we discuss how all available evidence suggests that mature chief cells in the adult, mammalian stomach are postmitotic, slowly turning over cells that arise via a relatively long-lived progenitor, the mucous neck ..
  16. ncbi Somatostatin suppresses ghrelin secretion from the rat stomach
    Mitsushi Shimada
    Department of Internal Medicine, Oita Medical University, Oita 879 5593, Japan
    Biochem Biophys Res Commun 302:520-5. 2003
    ..ghrelin is predominantly synthesized in a subset of endocrine cells in the oxyntic gland of the human and rat stomach, the mechanism regulating ghrelin secretion remains unknown...
  17. ncbi Helicobacter pylori infection and the development of gastric cancer
    N Uemura
    Department of Gastroenterology, Kure Kyosai Hospital, Kure City, Japan
    N Engl J Med 345:784-9. 2001
    ..Although many studies have found an association between Helicobacter pylori infection and the development of gastric cancer, many aspects of this relation remain uncertain...
  18. pmc Progenitors of interstitial cells of cajal in the postnatal murine stomach
    Andrea Lorincz
    Department of Physiology and Cell Biology, University of Nevada, Reno, USA
    Gastroenterology 134:1083-93. 2008
    ..Our goal was to identify ICC precursors in postnatal murine gastric muscles...
  19. pmc Helicobacter pylori uses motility for initial colonization and to attain robust infection
    Karen M Ottemann
    Department of Environmental Toxicology, University of California at Santa Cruz, Santa Cruz, California 95064, USA
    Infect Immun 70:1984-90. 2002
    Helicobacter pylori has been shown to require flagella for infection of the stomach. To analyze whether flagella themselves or motility is needed by these pathogens, we constructed flagellated nonmotile mutants...
  20. doi Helicobacter pylori: a ROS-inducing bacterial species in the stomach
    Osamu Handa
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kajiicho, Kawaramachidori Hirokouji Agaru, Kamigyou ku, Kyoto, 602 8566, Japan
    Inflamm Res 59:997-1003. 2010
    ..However, the precise mechanism by which Helicobacter pylori induces gastric carcinogenesis is presently unclear...
  21. pmc Conditional expression of Wnt9b in Six2-positive cells disrupts stomach and kidney function
    Susan M Kiefer
    Department of Internal Medicine, Saint Louis University, St Louis, Missouri, United States of America
    PLoS ONE 7:e43098. 2012
    ..animals also exhibited a malformed pyloric sphincter, duodenogastric reflux, and a transformation of the distal stomach into proximal fate...
  22. doi Kazal-type inhibitors in the stomach of Panstrongylus megistus (Triatominae, Reduviidae)
    Christian Karl Meiser
    Zoology Parasitology Group, Ruhr Universitat Bochum, Bochum, Germany
    Insect Biochem Mol Biol 40:345-53. 2010
    Triatomines inhibit the clotting of ingested blood in the stomach (anterior midgut)...
  23. doi Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells
    Stuart A C McDonald
    Histopathology Unit, London Research Institute, Cancer Research UK, London, United Kingdom
    Gastroenterology 134:500-10. 2008
    How mutations are established and spread through the human stomach is unclear because the clonal structure of gastric mucosal units is unknown...
  24. pmc Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity
    Catherine S Lee
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Genes Dev 16:1488-97. 2002
    ..Enteroendocrine cells are one of the four major cell types found in the gastric epithelium of the glandular stomach. To understand the molecular basis of enteroendocrine cell development, we have used gene targeting in mouse ..
  25. pmc Chitinase mRNA levels by quantitative PCR using the single standard DNA: acidic mammalian chitinase is a major transcript in the mouse stomach
    Misa Ohno
    Department of Applied Chemistry, Kogakuin University, Hachioji, Tokyo, Japan
    PLoS ONE 7:e50381. 2012
    ..We found that AMCase mRNA is synthesized at extraordinarily high levels in the mouse stomach. The level of this mRNA in the mouse stomach was 7- to 10-fold higher than the levels of the housekeeping genes ..
  26. ncbi Retinal dehydrogenase gene expression in stomach and small intestine of rats during postnatal development and in vitamin A deficiency
    P V Bhat
    CHUM Research Centre Hôtel Dieu Campus, Department of Medicine, University of Montreal, Que, Canada
    FEBS Lett 426:260-2. 1998
    ..We have recently shown the expression of RALDH transcript in the stomach and small intestine by reverse transcription polymerase chain reaction [Bhat, P.V., Labrecque J., Dumas, F...
  27. ncbi Identifying and quantifying prey consumption using stomach temperature change in pinnipeds
    Carey E Kuhn
    Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, Long Marine Laboratory, 100 Shaffer Road, CA 95064, USA
    J Exp Biol 209:4524-32. 2006
    ..This study examined the use of stomach temperature telemetry to identify and quantify prey consumed in both a phocid (northern elephant seal Mirounga ..
  28. pmc Origin, propagation and regional characteristics of porcine gastric slow wave activity determined by high-resolution mapping
    J U Egbuji
    Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand
    Neurogastroenterol Motil 22:e292-300. 2010
    ..High-resolution (HR) mapping has recently enabled an accurate description of human and canine gastric slow wave activity, and was employed here to define porcine gastric slow wave activity...
  29. pmc Characterization of a novel ghrelin cell reporter mouse
    Ichiro Sakata
    Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9077, USA
    Regul Pept 155:91-8. 2009
    ..We suggest that these novel ghrelin-hrGFP transgenic mice will serve as useful tools to better understand ghrelin cell physiology...
  30. ncbi The role of prednisolone and epinephrine on gastric tissue and erythrocyte antioxidant status in adrenalectomized rats
    A Yildirim
    Department of Biochemistry, Ataturk University, Medical Faculty, Erzurum, Turkey
    J Physiol Pharmacol 58:105-16. 2007
    ..Thus, the present study provides a physiological regulatory role of adrenal gland in the maintenance of oxidant/antioxidant balance in gastric tissue and erythrocyte...
  31. ncbi Endogenous acyl ghrelin is involved in mediating spontaneous phase III-like contractions of the rat stomach
    H Ariga
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Neurogastroenterol Motil 19:675-80. 2007
    ..Ghrelin was discovered as the endogenous ligand for the growth hormone secretagogue receptor (GHS-R) from the rat stomach. Ghrelin promotes gastric premature phase III (phase III-like contractions) in the fasted state in rats...
  32. ncbi Possible involvement of put A gene in Helicobacter pylori colonization in the stomach and motility
    Kazuhiko Nakajima
    Department of Infection Control and Prevention, Hyogo College of Medicine, Hyogo, Japan
    Biomed Res 29:9-18. 2008
    ..However, the energy metabolism of H. pylori in the stomach remains to be clarified. H...
  33. ncbi Laparoscopic treatment of type 2 diabetes mellitus for patients with a body mass index less than 35
    A L DePaula
    Department of Surgery, Hospital de Especialidades, Goiania, Brazil
    Surg Endosc 22:706-16. 2008
    ....
  34. pmc Cholecystokinin regulates expression of Y2 receptors in vagal afferent neurons serving the stomach
    Galina Burdyga
    Physiological Laboratory, School of Biomedical Sciences and School of Preclinical Veterinary Science, University of Liverpool, Liverpool, United Kingdom
    J Neurosci 28:11583-92. 2008
    ..With fasting there was loss of Y2R immunoreactivity in CCK1R-expressing neurons many of which projected to the stomach, but not in satellite cells or neurons projecting to the ileum or proximal colon...
  35. ncbi Secretion of ghrelin from rat stomach ghrelin cells in response to local microinfusion of candidate messenger compounds: a microdialysis study
    Charlotta Dornonville de la Cour
    Unit of Cellular and Molecular Pharmacology, Dept of Exp Med, University of Lund, BMC F13, S 221 84 Lund, Sweden
    Regul Pept 143:118-26. 2007
    Ghrelin is produced by A-like cells (ghrelin cells) in the mucosa of the acid-producing part of the stomach. The mobilization of ghrelin is stimulated by nutritional deficiency and suppressed by nutritional abundance...
  36. doi Microarray analysis identifies versican and CD9 as potent prognostic markers in gastric gastrointestinal stromal tumors
    Tomohiko Setoguchi
    Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Cancer Sci 102:883-9. 2011
    ..0078 and P = 0.0018). In addition to the c-kit gene mutation, genetic or epigenetic changes other than c-kit play important roles in the metastatic process. In particular, versican and CD9 are potential prognostic markers in gastric GIST...
  37. pmc Comparative analysis of human gut microbiota by barcoded pyrosequencing
    Anders F Andersson
    Swedish Institute for Infectious Disease Control, Solna, Sweden
    PLoS ONE 3:e2836. 2008
    ..Here we applied the technique to analyze microbial communities in throat, stomach and fecal samples...
  38. pmc NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein
    Sabine Brandt
    Department of Medical Microbiology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Proc Natl Acad Sci U S A 102:9300-5. 2005
    ..Thus, CagA is a multifunctional protein capable of effecting both actin remodeling and potentiation of chemokine release...
  39. pmc Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning
    Asa Kolterud
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Gastroenterology 137:618-28. 2009
    ..We profiled cellular Hedgehog response patterns from embryonic day 10.5 (E10.5) to adult in murine antrum, pyloric region, small intestine, and colon...
  40. ncbi Expression of cyclooxygenase-2 in dysplasia of the stomach and in intestinal-type gastric adenocarcinoma
    K Saukkonen
    Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland
    Clin Cancer Res 7:1923-31. 2001
    ..Furthermore, four of nine (44%) definitive dysplasias of the stomach that showed no evidence of invasion were positive for Cox-2...
  41. pmc Changes in interstitial cells of cajal with age in the human stomach and colon
    P J Gomez-Pinilla
    Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 23:36-44. 2011
    ..The aim of this study was to determine the effect of aging on ICC number and volume in the human stomach and colon.
  42. ncbi Stomach temperature telemetry reveals temporal patterns of foraging success in a free-ranging marine mammal
    Deborah Austin
    Department of Biology, Dalhousie University, Halifax, Nova Scotia B2H 4J1, Canada
    J Anim Ecol 75:408-20. 2006
    1. We studied feeding frequency in free-ranging grey seals using stomach temperature telemetry to test if previously reported sex differences in the diving, movement and diet were reflected in the temporal pattern of foraging success. 2...
  43. ncbi The differential proteome profile of stomach cancer: identification of the biomarker candidates
    Joung S Jang
    Department of Internal Medicine, Gyeongsang National University College of Medicine, and GyeongSang Institute of Health Sciences, Jinju, South Korea
    Oncol Res 14:491-9. 2004
    By comparative proteome analysis we searched for characteristic alterations of human stomach adenocarcinoma tissue and paired surrounding normal tissue...
  44. ncbi Gastric distention activates satiety circuitry in the human brain
    Gene Jack Wang
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 39:1824-31. 2008
    Gastric distention during meal ingestion activates vagal afferents, which send signals from the stomach to the brain and result in the perception of fullness and satiety. Distention is one of the mechanisms that modulates food intake...
  45. ncbi Cag pathogenicity island-independent up-regulation of matrix metalloproteinases-9 and -2 secretion and expression in mice by Helicobacter pylori infection
    Parag Kundu
    Indian Institute of Chemical Biology, Kolkata 700032, India
    J Biol Chem 281:34651-62. 2006
    ..These data show that H. pylori may act through different pathways other than cag PAI-mediated for gastric inflammation and contribute to up-regulation of MMP-9 via pro-inflammatory cytokines...
  46. ncbi Investigation of the distribution and excretion of okadaic acid in mice using immunostaining method
    Emiko Ito
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8673, Japan
    Toxicon 40:159-65. 2002
    ..The detection of OA continued for 2 weeks in the liver and blood vessels. Excretion from kidney, cecum and large intestine began even after 5 min of the administration, and the excretion from intestine continued for 4 weeks...
  47. doi Molecular characterization of the stomach microbiota in patients with gastric cancer and in controls
    Johan Dicksved
    Department of Microbiology, Swedish University of Agricultural Sciences, Uppsala, Sweden
    J Med Microbiol 58:509-16. 2009
    ..The respective role of these species in development of gastric cancer remains to be determined...
  48. ncbi The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats
    Yukari Date
    Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
    Gastroenterology 123:1120-8. 2002
    ..Ghrelin, a peptide primarily produced in the stomach, stimulates both feeding and growth hormone (GH) secretion...
  49. ncbi Prevalence and risk factors for ischemia, leak, and stricture of esophageal anastomosis: gastric pull-up versus colon interposition
    John W Briel
    Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, Los Angeles, CA 90033, USA
    J Am Coll Surg 198:536-41; discussion 541-2. 2004
    ..Reports of esophageal anastomotic complications often involve more gastric than colonic reconstructions and are incomplete because of fragmented followup by physicians unfamiliar with the surgical procedure...
  50. ncbi The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling
    Byeong Moo Kim
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Cell 8:611-22. 2005
    ..Expression of the conserved homeobox gene Barx1 is restricted to the stomach mesenchyme during gut organogenesis...
  51. pmc Ghrelin octanoylation mediated by an orphan lipid transferase
    Jesus A Gutierrez
    Integrative Biology, Eli Lilly and Company, 2001 West Main Street, Greenfield, IN 46140, USA
    Proc Natl Acad Sci U S A 105:6320-5. 2008
    ..Transcripts for both GOAT and ghrelin occur predominantly in stomach and pancreas...
  52. pmc Severe idiopathic gastroparesis due to neuronal and interstitial cells of Cajal degeneration: pathological findings and management
    N Zarate
    Digestive System Research Unit, University Hospital Vall d Hebron, Autonomous University of Barcelona, 08035 Barcelona, Spain
    Gut 52:966-70. 2003
    ..To our knowledge, this is the first time these rare histological findings have been described in a patient with idiopathic gastroparesis...
  53. pmc Gastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitro
    T Kitazawa
    Centre for Gastroenterological Research, Catholic University of Leuven, Gasthuisberg O and N, Box 701, B 3000 Leuven, Belgium
    Gut 54:1078-84. 2005
    ....
  54. pmc Comparison of five PCR methods for detection of Helicobacter pylori DNA in gastric tissues
    J J Lu
    Division of Clinical Pathology, Department of Pathology, Tri Service General Hospital and National Defense Medical Center, Taipei, Taiwan
    J Clin Microbiol 37:772-4. 1999
    ..The results of this study indicate that of the five PCR methods examined, the ureC (glmM) gene PCR is the most sensitive and specific for the detection of H. pylori in gastric biopsy specimens...
  55. pmc Grapefruit-seed extract attenuates ethanol-and stress-induced gastric lesions via activation of prostaglandin, nitric oxide and sensory nerve pathways
    Tomasz Brzozowski
    Department of Physiology, Jagiellonian University Medical College, Cracow, Poland
    World J Gastroenterol 11:6450-8. 2005
    ....
  56. ncbi A clinicopathologic study of mucinous adenocarcinoma of the stomach
    H Kawamura
    Department of Surgery, JA Sapporo Kosei Hospital, Sapporo, Japan
    Gastric Cancer 4:83-6. 2001
    BACKGROUND: Mucinous adenocarcinoma of the stomach is a rare histologic type of gastric adenocarcinoma and its features are still controversial. We attempted to clarify the clinicopathologic characteristics of this histologic type...
  57. ncbi A cluster of gustducin-expressing cells in the mouse stomach associated with two distinct populations of enteroendocrine cells
    Nicole Hass
    University of Hohenheim, Institute of Physiology, Garbenstrasse 30, 70599, Stuttgart, Germany
    Histochem Cell Biol 128:457-71. 2007
    ..cells which is located exactly at the boundary between the fundic and the oxyntic mucosa of the mouse stomach, at the so-called "limiting ridge"...
  58. pmc Helicobacter pylori CagL activates ADAM17 to induce repression of the gastric H, K-ATPase alpha subunit
    Arindam Saha
    Department of Medicine, University of California, San Diego, San Diego, California, USA
    Gastroenterology 139:239-48. 2010
    ..We investigated whether H pylori-induced repression of HKalpha is mediated by CagL activation of ADAM17 and release of heparin-binding epidermal growth factor (HB-EGF)...
  59. pmc Synergy of combined doxycycline/TUDCA treatment in lowering Transthyretin deposition and associated biomarkers: studies in FAP mouse models
    Isabel Cardoso
    Molecular Neurobiology Unit, IBMC Instituto de Biologia Molecular e Celular, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    J Transl Med 8:74. 2010
    ..The observed synergistic effect of doxycycline/TUDCA in the range of human tolerable quantities, in the transgenic TTR mice models prompts their application in FAP, particularly in the early stages of disease...
  60. ncbi Ferulic acid is quickly absorbed from rat stomach as the free form and then conjugated mainly in liver
    Zhaohui Zhao
    Laboratory of Food and Nutrition, Graduate School of Science and Technology, Chiba University, 648 Matsudo, Matsudo, Chiba 271 8510, Japan
    J Nutr 134:3083-8. 2004
    ..The purpose of this study was to confirm the hypothesis that FA is absorbed in rat stomach and metabolized mainly in the liver...
  61. ncbi Effect of GIP, GLP-1, insulin and gastrin on ghrelin release in the isolated rat stomach
    Florian Lippl
    Department of Internal Medicine II, Technical University of Munich, Ismaningerstr 22, 81675 Munich, Germany
    Regul Pept 119:93-8. 2004
    ..GLP-1), gastric inhibitory polypeptide (GIP), insulin, gastrin and somatostatin were examined on isolated rat stomach ghrelin secretion, which offers the advantage of avoiding systemic interactions...
  62. pmc STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice
    Matthias Ernst
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    J Clin Invest 118:1727-38. 2008
    ..Collectively, our data have identified IL-11 as a crucial cytokine promoting chronic gastric inflammation and associated tumorigenesis mediated by excessive activation of STAT3 and STAT1...
  63. ncbi Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ
    Akio Inui
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    FASEB J 18:439-56. 2004
    ..A late addition is the novel stomach hormone ghrelin, which is an endogenous agonist at the growth hormone secretagogne receptor and is the motilin-..
  64. doi T1R3 is expressed in brush cells and ghrelin-producing cells of murine stomach
    Nicole Hass
    Institute of Physiology, University of Hohenheim, Stuttgart, Germany
    Cell Tissue Res 339:493-504. 2010
    ..This finding suggests that ghrelin-releasing cells, which lack access to the stomach lumen, might receive chemosensory input from macronutrients in the circulation via T1R3.
  65. pmc Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling
    Matthew R Hayes
    Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 150:2654-9. 2009
    ..In one, Ensure was infused intraduodenally (0.4 ml/min for 20 min); in another, the stomach was distended (9 ml SILASTIC brand balloon) for 15 min before fourth icv Ex-9...
  66. ncbi Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas
    Raquel Almeida
    Institute of Molecular Pathology and Immunology, University of Porto IPATIMUP, 4200 Porto, Portugal
    J Pathol 199:36-40. 2003
    ....
  67. pmc Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach-brainstem axis
    Thomas Wultsch
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Pain 134:245-53. 2008
    Gastric acid challenge of the rat and mouse stomach is signalled to the brainstem as revealed by expression of c-Fos. The molecular sensors relevant to the detection of gastric mucosal acidosis are not known...
  68. pmc The complete genome sequence of Helicobacter pylori strain G27
    David A Baltrus
    Department of Biology, University of Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    J Bacteriol 191:447-8. 2009
    ..The H. pylori species exhibits unusually high levels of genetic variation between strains. Here we announce the complete genome sequence of H. pylori strain G27, which has been used extensively in H. pylori research...
  69. ncbi Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI
    L Marciani
    Magnetic Resonance Centre, School of Physics and Astronomy, Nottingham NG7 2RD, United Kingdom
    Am J Physiol Gastrointest Liver Physiol 280:G1227-33. 2001
    ..004), whereas increasing viscosity had a smaller effect. The volume of secretions within the stomach 60 min after ingestion was higher for the high-viscosity nutrient meal (P < 0.04)...
  70. ncbi Periplasmic protein HdeA exhibits chaperone-like activity exclusively within stomach pH range by transforming into disordered conformation
    Weizhe Hong
    The National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences and College of Chemistry and Molecular Engineering, Peking University, Beijing 100871
    J Biol Chem 280:27029-34. 2005
    The extremely acidic environment of the mammalian stomach, with a pH range usually between 1 and 3, represents a stressful challenge for enteric pathogenic bacteria such as Escherichia coli before they enter into the intestine...
  71. doi Clinicopathological features of stomach cancer with invasive micropapillary component
    Takeo Fujita
    Division of Digestive Surgery, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Gastric Cancer 15:179-87. 2012
    ..However, few reports have described invasive micropapillary carcinoma in the gastrointestinal tract, particularly its involvement in gastric cancer...
  72. pmc Inflammatory responses in the muscle coat of stomach and small bowel in the postoperative ileus model of guinea pig
    Hong Kyu Choi
    Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju ro, Gangnam Gu, Seoul 135 720, Korea
    Yonsei Med J 54:1336-41. 2013
    Small intestinal function returns first after surgery, and then the function of the stomach returns to normal after postoperative ileus (POI)...
  73. doi Lactobacillus apis sp. nov., from the stomach of honeybees (Apis mellifera), having an in vitro inhibitory effect on the causative agents of American and European foulbrood
    J Killer
    Institute of Animal Physiology and Genetics v v i, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 4 Krc, 142 20, Czech Republic
    Int J Syst Evol Microbiol 64:152-7. 2014
    ..The name Lactobacillus apis sp. nov. is proposed for this novel taxon; the type strain is R4B(T) ( = CCM 8403(T) = LMG 26964(T)). ..
  74. doi Identification of lineage-uncommitted, long-lived, label-retaining cells in healthy human esophagus and stomach, and in metaplastic esophagus
    Qiuwei Pan
    Department of Gastroenterology and Hepatology, Rotterdam, The Netherlands
    Gastroenterology 144:761-70. 2013
    ..of uncommitted, slowly cycling cells by tracking 5-iodo-2'-deoxyuridine (IdU) label-retaining cells (LRCs) in normal esophagus, Barrett's esophagus (BE), esophageal dysplasia, adenocarcinoma, and healthy stomach tissues from patients.
  75. pmc Narrow band imaging for the detection of gastric intestinal metaplasia and dysplasia during surveillance endoscopy
    Lisette G Capelle
    Department of Gastroenterology and Hepatology, ErasmusUniversity Medical Center, Room L 462, 3015 CE Rotterdam, The Netherlands
    Dig Dis Sci 55:3442-8. 2010
    ..Conclusions NBI increases the diagnostic yield for detection of advanced premalignant gastric lesions compared to routine WLE...
  76. doi SOX9 is expressed in normal stomach, intestinal metaplasia, and gastric carcinoma in humans
    Miho Sashikawa Kimura
    Division of Gastroenterology, Department of Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    J Gastroenterol 46:1292-9. 2011
    ..However, the expression of SOX9 in normal stomach, precancerous intestinal metaplasia, and gastric carcinoma has not yet been clarified...
  77. pmc Identification of Helicobacter pylori genes that contribute to stomach colonization
    David N Baldwin
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Infect Immun 75:1005-16. 2007
    Chronic infection of the human stomach by Helicobacter pylori leads to a variety of pathological sequelae, including peptic ulcer and gastric cancer, resulting in significant human morbidity and mortality...
  78. pmc The peopling of the Pacific from a bacterial perspective
    Yoshan Moodley
    Max Planck Institut für Infektionsbiologie, Department of Molecular Biology, Chariteplatz 1, 10117 Berlin, Germany
    Science 323:527-30. 2009
    ....
  79. ncbi The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1
    Victoria G Ramsey
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 134:211-22. 2007
    Continuous regeneration of digestive enzyme (zymogen)-secreting chief cells is a normal aspect of stomach function that is disrupted in precancerous lesions (e.g. metaplasias, chronic atrophy)...
  80. doi Laparoscopic splenectomy with or without devascularization of the stomach for liver cirrhosis and portal hypertension: a systematic review
    Xiao Dong Chen
    Department of Hepatobiliary Gastrointestinal Surgery, Sichuan Cancer Hospital and Institute, Chengdu, China
    ANZ J Surg 83:122-8. 2013
    ..However, it remains controversial whether laparoscopic splenectomy (LS) and devascularization (LSD) can be indicated and beneficial in these patients...
  81. doi Hexavalent chromium reduction kinetics in rodent stomach contents
    Deborah M Proctor
    ToxStrategies, Inc, Rancho Santa Margarita, CA 92688, United States
    Chemosphere 89:487-93. 2012
    Reduction of hexavalent chromium (Cr(VI)) to trivalent chromium (Cr(III)) in the stomach prior to absorption is a well-recognized detoxification process thought to limit the toxicity of ingested Cr(VI)...
  82. doi Gastrokines: stomach-specific proteins with putative homeostatic and tumor suppressor roles
    Trevelyan R Menheniott
    Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Rd, Parkville, Melbourne, VIC 3052, Australia
    Am J Physiol Gastrointest Liver Physiol 304:G109-21. 2013
    During the past decade, a new family of stomach-specific proteins has been recognized. Known as "gastrokines" (GKNs), these secreted proteins are products of gastric mucus-producing cell lineages...
  83. doi Transplantation of enteric cells expressing p75 in the rodent stomach
    Carrie L Geisbauer
    Biomedical Engineering Interdepartmental Program, University of California, Los Angeles, California 90095 7098, USA
    J Surg Res 174:257-65. 2012
    ..While these cells have shown tremendous promise in vitro, it remains to be determined whether they will survive and differentiate after in vivo transplantation...
  84. doi Is stomach spontaneously ageing? Pathophysiology of the ageing stomach
    Nathalie Salles
    Pôle de Gérontologie Clinique, Hopital Xavier Arnozan, Pessac, France
    Best Pract Res Clin Gastroenterol 23:805-19. 2009
    During ageing, histological and physiological modifications occur in the stomach leading to a confirmed state of gastric frailty defined by a decreased capacity of tissue repairing after mucosa gastric aggression...
  85. ncbi Expression of CYP3A isoforms and P-glycoprotein in human stomach, jejunum and ileum
    Roberto Canaparo
    Department of Anatomy, Pharmacology and Forensic Medicine, Division of Pharmacology and Experimental Therapeutics, University of Torino, Torino, Italy
    Clin Exp Pharmacol Physiol 34:1138-44. 2007
    ..expression of CYP3A4, CYP3A5, CYP3A7 and ABCB1 (P-gp) genes were quantified in five normal samples from the human stomach, seven from the jejunum and eight from the ileum by real-time reverse transcription-polymerase chain reaction and ..
  86. ncbi Fumarate reductase is essential for Helicobacter pylori colonization of the mouse stomach
    Z Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Microb Pathog 29:279-87. 2000
    ..pylori prevention and eradication...
  87. pmc Gastric stimulation for weight loss
    Meir Mizrahi
    Gastroenterology and Liver Units, Hebrew University Hadassah Medical Center, Ein Karem, Jerusalem, POB1200, Israel
    World J Gastroenterol 18:2309-19. 2012
    ..Here, we review the current status, potential mechanisms of action, and possible future applications of gastric stimulation for obesity...
  88. doi The effect on gastric tone of gastric electrical stimulation with trains of short pulses varies with sites and stimulation conditions
    Yong Lei
    Veterans Research Foundation, Oklahoma City, OK, USA
    Dig Dis Sci 53:2066-71. 2008
    ..Gastric electrical stimulation (GES) can improve symptoms in patients with gastroparesis and induce weight loss in obese subjects...
  89. pmc Bacterial flora concurrent with Helicobacter pylori in the stomach of patients with upper gastrointestinal diseases
    Yuan Hu
    State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
    World J Gastroenterol 18:1257-61. 2012
    ..To investigate the non-Helicobacter pylori (H. pylori) bacterial flora concurrent with H. pylori infection...
  90. ncbi Expression patterns of Wnt genes in mouse gut development
    H Lickert
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108, Freiburg, Germany
    Mech Dev 105:181-4. 2001
    ..Wnt11 is expressed in the epithelium of esophagus and colon, but also in mesenchymal cells of the stomach. Wnt5b and Wnt6 exhibit restricted expression in the epithelium of the esophagus...
  91. pmc Transgenic expression of interferon-γ in mouse stomach leads to inflammation, metaplasia, and dysplasia
    Li Jyun Syu
    Department of Dermatology, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Am J Pathol 181:2114-25. 2012
    ..We engineered mice expressing IFN-γ under the control of the stomach-specific H(+)/K(+) ATPase β promoter to test the potential role of this cytokine in gastric tumorigenesis...
  92. ncbi Profiling, comparison and validation of gene expression in gastric carcinoma and normal stomach
    Karin A Oien
    Cancer Research UK, Department of Medical Oncology, Cancer Research UK Beatson Laboratories, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
    Oncogene 22:4287-300. 2003
    ..We catalogued the genes expressed in two gastric adenocarcinomas and normal stomach, using serial analysis of gene expression (SAGE), and compared the profiles on-line with other glandular ..
  93. doi Changes in the bacterial population of the caecum and stomach of the rabbit in response to addition of dietary caprylic acid
    Eva Skřivanová
    Department of Animal Nutrition, Institute of Animal Science, Pratelstvi 815, 10401, Prague, Czech Republic
    Vet Microbiol 144:334-9. 2010
    The effect of caprylic acid, either in its pure form, or as Akomed R, on the microbial community of the stomach and caecum of farmed rabbits was investigated...
  94. pmc Structure of the human gastric bacterial community in relation to Helicobacter pylori status
    Ana Maldonado-Contreras
    Department of Biology, University of Puerto Rico, San Juan, PR
    ISME J 5:574-9. 2011
    The human stomach is naturally colonized by Helicobacter pylori, which, when present, dominates the gastric bacterial community...
  95. pmc Serum biomarker tests are useful in delineating between patients with gastric atrophy and normal, healthy stomach
    Katsunori Iijima
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1, Seiryo machi, Aobaku, Sendai 980 8574, Japan
    World J Gastroenterol 15:853-9. 2009
    To study the value of serum biomarker tests to differentiate between patients with healthy or diseased stomach mucosa: i.e...
  96. doi Evidence of tricellulin expression by immune cells, particularly microglia
    Cibelle Mariano
    Research Institute for Medicines and Pharmaceutical Sciences iMED UL, Faculty of Pharmacy, University of Lisbon, Av Prof Gama Pinto, 1649 003 Lisbon, Portugal
    Biochem Biophys Res Commun 409:799-802. 2011
    ..specialized tricellular TJs but also present at bicellular contacts between epithelial cells, namely in the stomach. Interestingly, several TJ proteins have been found in other than epithelial cells, as astrocytes, and ..
  97. ncbi Severe fibrosis and increased expression of fibrogenic cytokines in the gastric wall of systemic sclerosis patients
    Mirko Manetti
    University of Florence, Florence, Italy
    Arthritis Rheum 56:3442-7. 2007
    ..The present study was undertaken to evaluate the fibrotic process and the expression of fibrogenic cytokines in the gastric wall of SSc patients with gastroesophageal involvement...
  98. pmc Analysis of stomach and gut microbiomes of the eastern oyster (Crassostrea virginica) from coastal Louisiana, USA
    Gary M King
    Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, USA
    PLoS ONE 7:e51475. 2012
    We used high throughput pyrosequencing to characterize stomach and gut content microbiomes of Crassostrea virginica, the Easter oyster, obtained from two sites, one in Barataria Bay (Hackberry Bay) and the other in Terrebonne Bay (Lake ..
  99. pmc Gastric electrical stimulation with the TANTALUS System in obese type 2 diabetes patients: effect on weight and glycemic control
    Claudia P Sanmiguel
    Cedars Sinai Medical Center, Los Angeles, California, USA
    J Diabetes Sci Technol 3:964-70. 2009
    ..This study was conducted under a Food and Drug Administration/Institutional Review Board-approved investigational device exemption...
  100. pmc Proinflammatory cytokine gene expression in the stomach correlates with vaccine-induced protection against Helicobacter pylori infection in mice: an important role for interleukin-17 during the effector phase
    Carl Fredrik Flach
    Department of Medical Microbiology and Immunology and University of Gothenburg Vaccine Research Institute, University of Gothenburg, Box 435, 405 30 Gothenburg, Sweden
    Infect Immun 79:879-86. 2011
    ..Vaccine-induced protection was assessed by measuring H. pylori colonization in the stomach. Gastric gene expression of T(h)1- and/or T(h)17-associated cytokines was analyzed by quantitative PCR, and ..
  101. doi Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice
    Pei wen Pan
    Institute of Medical Technology, University of Tampere, Biokatu 6, 33520, Tampere, Finland
    Transgenic Res 20:675-98. 2011
    ..We also examined transcriptomic responses to CAVI deficiency in the submandibular gland, stomach, and duodenum of Car6 (-/-) mice. Car6 (-/-) mice were viable and fertile and had a normal life span...

Research Grants70

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..but should not consume any other beverages or any kind of food until at least 30 minutes have passed to prevent stomach upset. The pills should be stored in the refrigerator...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..but should not consume any other beverages or any kind of food until at least 30 minutes have passed to prevent stomach upset. The pills should be stored in the refrigerator...
  3. THE AGRICULTURAL HEALTH STUDY - FIELD STATIONS
    Charles Lynch; Fiscal Year: 2010
    ..Case-control studies of cancers of the brain and stomach in Nebraska provide an opportunity to assess the role of agricultural, general environmental, and lifestyle ..
  4. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2010
    ..Case-control studies of cancers of the brain and stomach in Nebraska provide an opportunity to assess the role of agricultural, general environmental, and lifestyle ..
  5. Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related ca
    Jose M Garcia; Fiscal Year: 2013
    ..However, treatments for this condition are lacking. Ghrelin, a novel hormone released primarily by the stomach stimulates GH secretion, increases energy intake and decreases energy expenditure...
  6. Mucosal Immunity, Vaccines and Microbiota Interplay in Humans and Animal
    Marcelo B Sztein; Fiscal Year: 2013
    ..e., the stomach, ileum and colon, respectively)...
  7. DNA Damage and Response in the Bladder Microenvironment.
    Bradley P Dixon; Fiscal Year: 2013
    ..In the in vivo portion of these experiments, we will perform bladder augmentations using stomach, small intestine, or colon tissue as well as sham operations in Sprague Dawley rats...
  8. Mechanism of Bladder Overactivity in Pelvic Ischemia
    Kazem M Azadzoi; Fiscal Year: 2013
    ..Ischemia is one of the leading causes of smooth muscle spasm in the stomach, intestine, uterus, and bronchioles...
  9. MOLECULAR MECHANISMS OF COMPLEX MIXTURE TOXICITY
    Alvaro Puga; Fiscal Year: 2013
    ..with concomitant exposures to aromatic hydrocarbon procarcinogens, resulting in health problems including lung, stomach and intestinal tract tumors...
  10. Ghrelin: Behavioral, Anatomical, and Physiological Components of Obesity
    BRETT JOHN WARREN TEUBNER; Fiscal Year: 2011
    ..This research will focus on the endogenous stomach-released 'hunger peptide', ghrelin, that is secreted in direct proportion to the last time food was ..
  11. FOLLOW UP OF THE ALPHA-TOCOPHEROL, BETA-CAROTENE CANCER PREVENTION (ATBC) STUDY
    Jarmo Virtamo; Fiscal Year: 2010
    ..through 2005 include approximately 2,800 lung, 2,000 prostate, 700 colorectal, 500 bladder, 300-400 each for stomach, pancreas, and kidney cancers, 300 head and neck, and 1,100 for other sites combined...
  12. Mechanims of CNS Autonomic Regulation by EA
    John C Longhurst; Fiscal Year: 2013
    ..modulation with the largest effect occurring during low frequency, low intensity EA at the pericardial and stomach meridians, specifically at P5-P6 and St36-St37, since these sets of acupoints provide significant input to ..
  13. Arginine Availability and Metabolism in the Immune Evasion of H. pylori
    Keith T Wilson; Fiscal Year: 2013
    ..We now show that a substantial portion of GMacs in the H. pylori-infected stomach are regulatory macrophages (Mregs), which may contribute to persistence of the infection...
  14. Developing Physics-Based Virtual Simulation Technology for Natural Orifice Transl
    DANIEL BOUGERE JONES; Fiscal Year: 2013
    ..as a natural successor of laparoscopic surgery, where internal organs are accessed by perforating the viscera (stomach, colon or vagina) using a flexible endoscope inserted through natural orifices such as the mouth, anus or vagina;..
  15. Genetic Susceptibility and Biomarkers of Platinum-related Toxicities
    Lois B Travis; Fiscal Year: 2013
    ..8 million patients are diagnosed with cancers of colon, rectum, cervix, endometrium, bladder, stomach, head and neck, lung, esophagus, pancreas, osteosarcoma, ovary, and testis, for which first-line therapy can ..
  16. High affinity capturing agents for strychnine
    Kit S Lam; Fiscal Year: 2011
    ..Treatments for strychnine poisoning are primarily supportive and symptomatic care. At acidic pH (stomach), strychnine is ionized and rapidly and completely absorbed in the small intestine...
  17. Nitric Oxide and gastric motility in female diabetics
    Pandu R Gangula; Fiscal Year: 2010
    ..nNOS expression and altered (delay or accelerate) gastric emptying (mechanical due to loss of neuronal control of stomach muscle contractions and relaxations) in diabetic stomachs remain unknown...
  18. Modulation of cancer prevention by social stress
    Hildegard M Schuller; Fiscal Year: 2010
    ..PDAC prevention and also provide a foundation for improved prevention of cancer of the colon, prostate, breast, stomach and ovary, all of which are stimulated by beta-adrenergic signaling...
  19. RidCancerPain Intervention in a Hispanic Population Along the US-Mexico Border
    KRISTYNIA MARIE contact ROBINSON; Fiscal Year: 2010
    ..are of special concern for those of Hispanic origin, because cancers with higher rates among Hispanics, such as stomach, liver, biliary tract, and uterine cervix, are generally associated with extreme pain (American Cancer Society, ..
  20. RYGB Improves Metabolism by Interrupting the Gastric Adipose Tissue Axis
    Naji N Abumrad; Fiscal Year: 2013
    ..levels of gastric-derived ghrelin and leptin, occurring as early as 15 minutes after the surgical interruption of stomach during the RYGB procedure...
  21. THE ROLE OF CELL SHAPE AND CELL WALL IN HELICOBACTER PYLORI PATHOGENESIS
    NINA REDA SALAMA; Fiscal Year: 2010
    ..provided by applicant): Evident in its name, Helicobacter pylori is a helical bacterium that colonizes the human stomach causing clinical outcomes ranging from mild gastritis to peptic ulcer and gastric cancer. Descriptions of H...
  22. REGULATION OF ATROPHY-INDUCED PROGENITOR CELLS IN THE GASTRIC CORPUS
    Jason C Mills; Fiscal Year: 2013
    ..modulator tamoxifen causes ablation of nearly all parietal cells, the acid-secreting lineage, in the mouse stomach within 3 days...
  23. The upper airway and the Sudden Infant Death Syndrome
    Donald Bartlett; Fiscal Year: 2012
    ..One suspected mechanism of SIDS is that stomach contents, regurgitated into the larynx, trigger a powerful reflex that stops breathing and leads to death from ..
  24. The Role of Estradiol and Sex in the Effects of Ghrelin on Meal Patterns and Fos-
    PETER BUTERA; Fiscal Year: 2009
    ..Along these lines, ghrelin is a peptide hormone synthesized principally in the stomach that binds to a receptor in the brain and regulates growth hormone secretion...
  25. Metagenomic profiling of oral polymicrobial flora in head and neck cancers
    Charis Eng; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): When H. pylori in the stomach was linked with gastric cancer, and its eradication associated with regression, a paradigm-shifting model of carcinogenesis was created...
  26. Lycopene Chemoprevention of Lung Cancer in Ferret
    Xiang Dong Wang; Fiscal Year: 2010
    ..It appears to provide protection against a broad range of epithelial cancers, including lung, prostate, stomach and colon...
  27. Acid Adaptation Targets for Eradication of Helicobacter pylori
    George Sachs; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Helicobacter pylori infects the stomach of half of the world's population. This infection is a primary cause of peptic ulcer disease and a high risk factor for gastric cancer...
  28. CANCER AND CHANGING TRENDS IN US MORTALITY INEQUITIES: 1960-2004
    Nancy Krieger; Fiscal Year: 2010
    ..gender, and age;THE SITE-SPECIFIC ANALYSES WILL FOCUS ON: lung, colorectal, breast, prostate, cervix, stomach, AND liver CANCER [TEXT DELETED], AND (2) CREATE A DEATH CERTIFICATE QUALITY PROXY (DCQP) MEASURE, BASED ON THE ..
  29. Plague biofilm formation--regulation and function
    ROBERT DONALD PERRY; Fiscal Year: 2013
    ..rat flea, Xenopsylla cheopis, formation of the biofilm leads to blockage of the valve between the esophagus and stomach of the flea, known as the proventriculus. Blockage of the proventriculus may extend the transmission time...
  30. Compounds to treat Helicobacter pylori infection
    Kenneth Coleman; Fiscal Year: 2013
    ..H. pylori causes acid reflux, ulcers and stomach cancer...
  31. Effect of Helicobacter pylori cell shape on pathogenesis
    LAURA ELIZABETH MARTINEZ; Fiscal Year: 2013
    ..provided by applicant): Helicobacter pylori is a Gram-negative helical rod-shaped bacterium that infects the stomach of 50% of all humans. H...
  32. An Innovative Endoscopic Instrument with Full-Field Viewing and Intelligent Imagi
    STEVEN YI; Fiscal Year: 2010
    ..endoscopic procedures in the United States alone for the examinations of digestive tract including the esophagus, stomach, small intestine, colon, and rectum. The associated national cost is over $60 billion per year...
  33. Effect of Chronic Proton Pump Inhibitor Therapy on Bone Mineral Density and Bone
    Yu Xiao Yang; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Proton pump inhibitors (PPIs) are among the most widely used medications. These potent stomach acid suppressants may reduce bone density and increase the risk of osteoporotic fractures...
  34. Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
    Joan Lappe; Fiscal Year: 2013
    ..a major source of vitamin D (vit D), has been found for cancers of the breast, colon, rectum, ovary, prostate, stomach, and numerous other cancers...
  35. Transport ATPases: From Molecules to Maladies
    Rajini Rao; Fiscal Year: 2010
    ..Some are targets of drugs used to treat heart failure and stomach ulcers...
  36. Oral immune modulatory therapy using antigens bioencapsulated in plant cells
    Roland W Herzog; Fiscal Year: 2013
    ..Bioencapsulated antigens are protected in the stomach from acids or enzymes, but are released in the gut when plant cell walls are digested by commensal bacteria...
  37. Morphogenesis of mammalian gut endoderm
    Anna Katerina Hadjantonakis; Fiscal Year: 2012
    ..The gut endoderm gives rise to the major cell types of many internal organs, including the thyroid, thymus, lung, stomach, liver, pancreas, intestine and bladder...
  38. ROLE AND REGULATION OF PROTEIN KINASE C ISOENZYMES
    Yusuf Awni Hannun; Fiscal Year: 2013
    ..as well as pharmacologic agents important for blood pressure regulation, blood clotting, gastric ulcers and stomach acidity, treatment of depression, and other diseases)...
  39. CELLULAR MECHANISMS IN THE INDUCTION OF AROMATASE
    Carole R Mendelson; Fiscal Year: 2013
    ..Notably, ERR3 regulates K+ homeostasis in heart, stomach and kidney of mice via control of a number of hypertension-associated genes;further, ERR3 single nucleotide ..
  40. Structure-Function Studies of the Proton-Gated Urea Channel from H. Pylori
    Hartmut Luecke; Fiscal Year: 2013
    ..1 in the acidic environment of the stomach, as low as pH 2.5, thus allowing colonization of the stomach...
  41. The effects of glucose on central vagal brainstem circuits
    KIRSTEEN NAIRN BROWNING; Fiscal Year: 2013
    ..during swallowing, for example) that induces gastric relaxation and suppression of motility, allowing the stomach to accept ingesta isobarically...
  42. Oxyntic Atrophy and Novel Gastric Lineages
    JAMES RICHARD GOLDENRING; Fiscal Year: 2013
    ..The vast majority of gastric cancer evolves in the stomach in the setting of chronic atrophic gastritis usually in association with Helicobacter pylori infection...
  43. Control of bacterial morphology and differentiation
    Yves V Brun; Fiscal Year: 2013
    ..during the infection process, and the helical shape of Helicobacter pylori is important for colonization of the stomach. Understanding how bacteria achieve changes in morphology and modes of growth and couple them to the localization ..
  44. EPIDEMIOLOGY OF HELICOBACTER PYLORI TRANSMISSION
    Julie Parsonnet; Fiscal Year: 2010
    ..pylori in the stomach will also be assessed with endoscopy and biopsy...
  45. DNA recombinational repair in Helicobacter pylori
    Ge Wang; Fiscal Year: 2010
    ..Studying the DNA recombinational repair system will help us understand how H. pylori can adapt to and persist in the human stomach.
  46. Susceptibility and Protective Immunity to Noroviruses
    Ralph S Baric; Fiscal Year: 2013
    ..Heralded as the "stomach flu", retirement community outbreaks are pervasive and can result in 1-2% mortality rates in the elderly...
  47. FOUR-DIMENSIONAL MRI FOR IMAGE-GUIDED RADIATION THERAPY FOR PANCREATIC CANCER
    Yanle Hu; Fiscal Year: 2013
    ..dose is limited by the radiation intolerance of adjacent normal organs such as small intestine, duodenum, stomach, kidneys and spinal cord...
  48. Functional Analysis of MGAT Enzymes
    Robert V Farese; Fiscal Year: 2010
    ..Two murine MGAT genes have been identified. Mgatl is expressed mainly in the stomach and kidney of mice, and preliminary studies have localized this expression to epithelial cells of these tissues...
  49. Daily Mouth Care to Prevent Pneumonia in Nursing Homes: A Systems-Level Approach
    Sheryl Zimmerman; Fiscal Year: 2013
    ..In aspiration, contents from the mouth, throat, or stomach that are colonized with pathogenic bacteria are inhaled into the lungs...
  50. Ednrb Regulation of Gastrointestinal Motility
    KENT CHARLES WILLIAMS; Fiscal Year: 2013
    ..Signaling through endothelin receptor B (Ednrb) influences motility in the esophagus, stomach, small intestine, and colon...
  51. Regulation of SMAD4 and BMPR1A Expression in Juvenile Polyposis
    James R Howe; Fiscal Year: 2010
    ..an autosomal dominant syndrome predisposing to the development of hamartomatous polyps of the colon, rectum, and stomach. Affected patients have an approximately 50% risk of developing gastrointestinal cancer...
  52. Effect of Bariatric Surgery on Mechanisms of Type 2 Diabetes: The B2D Trial
    Philip R Schauer; Fiscal Year: 2013
    ..RYGB is a bariatric procedure that involves stapling the upper stomach to reduce stomach capacity to 15-30 mls and bypassing the remaining stomach, duodenum and a small portion of the ..
  53. Polyamine-dependent regulation of Vibrio cholerae biofilm formation
    Ece Karatan; Fiscal Year: 2011
    ..cholerae not only from the harsh conditions in the environment, but also from the acidic conditions of the host stomach. There is also evidence of V. cholerae biofilms in the host intestinal environment, which suggests that V...
  54. POLLEN GRAINS AS TROJAN HORSES FOR ORAL VACCINATION
    Harvinder Singh Gill; Fiscal Year: 2012
    ..The major roadblocks that continue to obstruct successful oral vaccination are the degradation of vaccines in the stomach and their poor uptake across the intestinal epithelial cell lining...
  55. Beta-Defensins: Mediators of Gastrointestinal Inflammation
    Steven M Cohn; Fiscal Year: 2010
    ..Additional components of the innate immune system are the epithelial cells that line the stomach and intestines...
  56. Modulation of Outer Membrane Protein Expressin in Helicobacter pylori
    Jay V Solnick; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Helicobacter pylori commonly infects the stomach, where it causes inflammation (gastritis) in all individuals and peptic ulcer disease or gastric cancer in some. H...
  57. HDAC Inhibitors Inspired by Natural Products
    Dennis L Wright; Fiscal Year: 2012
    Cancers of the digestive organs such as the stomach, colon and the kidney are prevalent and can be very difficult to treat, thus providing a compelling rationale for the pursuit of new agents that target these types of malignancies...
  58. Iron transport in Shigella and pathogenic E.coli
    Shelley M Payne; Fiscal Year: 2012
    ..will help define the global regulatory patterns that allow Shigella to respond to the various environments that it encounters in the host such as the acidity of the stomach and the low iron environment within host cells.
  59. Pharmacogenomics of Gastric Function &Weight in Obesity
    MICHAEL L CAMILLERI; Fiscal Year: 2013
    ..Previous research has identified that the functions of the human stomach are important determinants of fullness while eating, a factor that influences cessation of food intake...
  60. Mechanism of DLC1-mediated tumor suppression
    Su Hao Lo; Fiscal Year: 2013
    ..is associated with a variety of cancer types including prostate, lung, breast, kidney, colon, uterus, ovary, and stomach. Mutations in DLC1 that attenuate its expression and function have been identified in prostate and colon cancer...
  61. ISU Vet-LIRN Collaborative Validation of Testing Methods on Animal Diagnostic Spe
    WILSON KIIZA RUMBEIHA; Fiscal Year: 2013
    ..offers a suite of validated tests of feed/food borne toxins in feeds and tissues of animal origin including stomach/rumen contents, liver, kidney, fat, milk and/or eggs...
  62. Genetic and Biochemical Analysis of DNA Exchange in Helicobacter pylori
    MARION SHONN DORER; Fiscal Year: 2010
    ..Studying the bacterium will help us develop new drugs that will rid people of the infection and reduce greatly their risk of developing ulcers or stomach cancer.
  63. CAMPYLOBACTER PYLORIDIS IN GASTRODUODENAL DISEASE
    David Graham; Fiscal Year: 1991
    The presence of C. pyloridis in the stomach has been associated with peptic ulcer disease, non-ulcer dyspepsia and gastritis...
  64. Assesment of Meridian Theory in the Vascular System
    DAVID DAEKYUNG KIM; Fiscal Year: 2010
    ..We will use three different meridians: stomach meridian, liver meridian, large intestine meridian, to test our hypothesis...
  65. LINGUAL SEROUS GLANDS--REGULATION OF ENZYME SECRETION
    RUTH FIELD; Fiscal Year: 1992
    ..only known source of lingual lipase which is responsible for the first step in lipid digestion occurring in the stomach at acid pH...
  66. Dual-pulse electrical stimulation for gastroparesis
    Jiande Chen; Fiscal Year: 2004
    Gastroparesis is a common disease defined as the delayed emptying of the stomach. It is present in at least 20% of about 150 million patients with diabetes worldwide and in more than 20% of patients with functional dyspepsia that ..
  67. ENTERIC NEURONS: 5HT, 5HT2B RECEPTORS AND DEVELOPMENT
    Elena Fiorica Howells; Fiscal Year: 2001
    DESCRIPTION (Adapted from Applicant's Abstract): Since its discovery in the fundus (rumen) of the rat stomach, the 5-HT2B receptor has been assumed to be expressed in the gut only by smooth muscle...
  68. EFFECT OF DIETARY METHYLXANTHINES ON FLUORIDE METABOLISM
    JARVIS CHAN; Fiscal Year: 1990
    ..stimulation of gastric secretion by MX will favor the formation of HF and facilitate the absorption of F from the stomach. Degree of F absorption from the stomach under the influence of MX will be compared to that from proximal small ..
  69. Helicobacter pylori and the gastric microbial community in rhesus macaques
    Jay V Solnick; Fiscal Year: 2010
    Helicobacter pylori commonly infects the stomach, where it causes inflammation (gastritis) in all individuals and peptic ulcer disease or gastric cancer in some...
  70. MODULATORS OF GASTRIC HISTAMINE RELEASE IN VIVO
    John Gerber; Fiscal Year: 1993
    ..arterial and gastric venous plasma concentrations of histamine and 1-methyl histamine across the corpus of the stomach where most of the histamine-containing mast cells and endocrine cells are contained...