upper gastrointestinal tract

Summary

Summary: The segment of GASTROINTESTINAL TRACT that includes the ESOPHAGUS; the STOMACH; and the DUODENUM.

Top Publications

  1. ncbi T-cell-mediated tumor immune surveillance and expression of B7 co-inhibitory molecules in cancers of the upper gastrointestinal tract
    Binfeng Lu
    Department of Immunology, University of Pittsburgh School of Medicine, E1047 BST, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Immunol Res 50:269-75. 2011
  2. ncbi Role of melatonin in upper gastrointestinal tract
    S J Konturek
    Department of Physiology, Jagiellonian University Medical College, 16 Grzegorzecka Street, Cracow, Poland
    J Physiol Pharmacol 58:23-52. 2007
  3. ncbi Endoscopic techniques and management of foreign body ingestion and food bolus impaction in the upper gastrointestinal tract: a retrospective analysis of 139 cases
    Panagiotis Katsinelos
    Department of Endoscopy and Motility Unit, Central Hospital, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece
    J Clin Gastroenterol 40:784-9. 2006
  4. pmc The role of microRNAs in cancers of the upper gastrointestinal tract
    Shumei Song
    Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Nat Rev Gastroenterol Hepatol 10:109-18. 2013
  5. pmc Management of non-variceal upper gastrointestinal tract hemorrhage: controversies and areas of uncertainty
    Eric P Trawick
    Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN 37232, United States
    World J Gastroenterol 18:1159-65. 2012
  6. ncbi Adherence to gastroprotection during cyclooxygenase 2 inhibitor treatment and the risk of upper gastrointestinal tract events: a population-based study
    Vera E Valkhoff
    Erasmus University Medical Centre, Rotterdam, The Netherlands
    Arthritis Rheum 64:2792-802. 2012
  7. pmc Fc-epsilon-RI, the high affinity IgE-receptor, is robustly expressed in the upper gastrointestinal tract and modulated by mucosal inflammation
    Christina Bannert
    Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria
    PLoS ONE 7:e42066. 2012
  8. ncbi Microbial colonization of the upper gastrointestinal tract in patients with Barrett's esophagus
    Sandra Macfarlane
    Dundee University Gut Group, Ninewells Hospital Medical School, Dundee, United Kingdom
    Clin Infect Dis 45:29-38. 2007
  9. ncbi An evaluation of endoscopic indications and findings related to nonvariceal upper-GI hemorrhage in a large multicenter consortium
    Brintha K Enestvedt
    Department of Internal Medicine, Oregon Health and Sciences University, Portland, Oregon 97214, USA
    Gastrointest Endosc 67:422-9. 2008
  10. ncbi Combined preoperative endoscopic and laparoscopic ultrasonography for prediction of R0 resection in upper gastrointestinal tract cancer
    M B Mortensen
    Department of Surgical Gastroenterology, Centre for Surgical Ultrasound, Odense University Hospital, DK 5000 Odense C, Denmark
    Br J Surg 93:720-5. 2006

Detail Information

Publications242 found, 100 shown here

  1. ncbi T-cell-mediated tumor immune surveillance and expression of B7 co-inhibitory molecules in cancers of the upper gastrointestinal tract
    Binfeng Lu
    Department of Immunology, University of Pittsburgh School of Medicine, E1047 BST, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Immunol Res 50:269-75. 2011
    ..Future tumor vaccine design should combine blockade of B7 inhibitory molecules and enhancement of T-bet and Eomes levels within the tumor microenvironment...
  2. ncbi Role of melatonin in upper gastrointestinal tract
    S J Konturek
    Department of Physiology, Jagiellonian University Medical College, 16 Grzegorzecka Street, Cracow, Poland
    J Physiol Pharmacol 58:23-52. 2007
    ..This review concentrates on the generation and pathophysiological implication of melatonin in upper GIT...
  3. ncbi Endoscopic techniques and management of foreign body ingestion and food bolus impaction in the upper gastrointestinal tract: a retrospective analysis of 139 cases
    Panagiotis Katsinelos
    Department of Endoscopy and Motility Unit, Central Hospital, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece
    J Clin Gastroenterol 40:784-9. 2006
    ..Successful foreign body and food bolus removal may depend on the method used, the choice of device, and the experience level of the endoscopist, although few papers report experience and outcome of tertiary centers...
  4. pmc The role of microRNAs in cancers of the upper gastrointestinal tract
    Shumei Song
    Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Nat Rev Gastroenterol Hepatol 10:109-18. 2013
    Cancers of the oesophagus, gastro-oesophageal junction and stomach (upper gastrointestinal tract cancers; UGICs) pose a major health risk around the world...
  5. pmc Management of non-variceal upper gastrointestinal tract hemorrhage: controversies and areas of uncertainty
    Eric P Trawick
    Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN 37232, United States
    World J Gastroenterol 18:1159-65. 2012
    b>Upper gastrointestinal tract hemorrhage (UGIH) remains a common presentation requiring urgent evaluation and treatment...
  6. ncbi Adherence to gastroprotection during cyclooxygenase 2 inhibitor treatment and the risk of upper gastrointestinal tract events: a population-based study
    Vera E Valkhoff
    Erasmus University Medical Centre, Rotterdam, The Netherlands
    Arthritis Rheum 64:2792-802. 2012
    ..We undertook this study to determine the association between GPA adherence and UGI tract events among patients receiving coxibs...
  7. pmc Fc-epsilon-RI, the high affinity IgE-receptor, is robustly expressed in the upper gastrointestinal tract and modulated by mucosal inflammation
    Christina Bannert
    Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria
    PLoS ONE 7:e42066. 2012
    ..Currently, a detailed characterization of FcεRI expression throughout the human gut is lacking. The aim of this study was to define the expression pattern of FcεRI in the GI tract...
  8. ncbi Microbial colonization of the upper gastrointestinal tract in patients with Barrett's esophagus
    Sandra Macfarlane
    Dundee University Gut Group, Ninewells Hospital Medical School, Dundee, United Kingdom
    Clin Infect Dis 45:29-38. 2007
    ..The aim of this study was to characterize microbial communities in esophageal aspirate specimens and on distal esophageal mucosal samples from patients with BE...
  9. ncbi An evaluation of endoscopic indications and findings related to nonvariceal upper-GI hemorrhage in a large multicenter consortium
    Brintha K Enestvedt
    Department of Internal Medicine, Oregon Health and Sciences University, Portland, Oregon 97214, USA
    Gastrointest Endosc 67:422-9. 2008
    ..There is limited information about patients with UGIH who are evaluated by endoscopy at nonacademic settings, which comprise the majority of endoscopic practices in the United States...
  10. ncbi Combined preoperative endoscopic and laparoscopic ultrasonography for prediction of R0 resection in upper gastrointestinal tract cancer
    M B Mortensen
    Department of Surgical Gastroenterology, Centre for Surgical Ultrasound, Odense University Hospital, DK 5000 Odense C, Denmark
    Br J Surg 93:720-5. 2006
    This study evaluated the ability of combined endoscopic and laparoscopic ultrasonography to predict R0 resection and avoid unnecessary surgery in patients with upper gastrointestinal tract cancer (UGIC).
  11. ncbi Comparative study of the effect of luminal hypotonicity on mucosal permeability in rat upper gastrointestinal tract
    L Pihl
    Department of Neuroscience, Division of Physiology, Biomedical Center, Uppsala University, Uppsala, Sweden
    Acta Physiol (Oxf) 193:67-78. 2008
    ..To investigate whether the increase in mucosal permeability in the duodenum, induced by luminal hypotonicity, also occurs in the stomach and the jejunum and whether this increase in permeability can be explained by epithelial injury...
  12. ncbi Antimicrobial host defense in the upper gastrointestinal tract
    Yoshio Hosaka
    Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
    Eur J Gastroenterol Hepatol 20:1151-8. 2008
    ..Herein, we aimed to systematically assess the distribution and quantity of different antimicrobial host factors as well as, for the first time, functional mucosal antimicrobial activity in the upper gastrointestinal tract.
  13. pmc Caustic injury of the upper gastrointestinal tract: a comprehensive review
    Sandro Contini
    Department of Surgical Sciences, University of Parma, 43125 Parma, Italy
    World J Gastroenterol 19:3918-30. 2013
    ..Possible late development of esophageal cancer, though probably overemphasized, entails careful and long-term endoscopic screening. ..
  14. ncbi Upper gastrointestinal tract endoscopy indications in northern Nigeria
    A B Olokoba
    Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria
    J Coll Physicians Surg Pak 19:327-8. 2009
    b>Upper gastrointestinal tract endoscopy is one of the commonly performed endoscopic procedures, and has only recently become available in Nigeria...
  15. ncbi Radiologic assessment of the upper gastrointestinal tract: does it play an important preoperative role in bariatric surgery?
    Ravi N Sharaf
    Division of Gastroenterology and Department of Surgery, New York University School of Medicine, New York, NY, USA
    Obes Surg 14:313-7. 2004
    ..The role of upper GI series (UGIS) before bariatric surgery is controversial. The aim of this study was to evaluate the diagnostic yield and cost of routine UGIS prior to bariatric surgery...
  16. ncbi Investigation of upper gastrointestinal tract involvement and H. pylori presence in lichen planus: a case-controlled study with endoscopic and histopathological findings
    Belcin Izol
    University of Uludag, School of Medicine, Department of Dermatology, Bursa, Turkey
    Int J Dermatol 49:1121-6. 2010
    ..Infectious agents including H. pylori and other autoantigens have been investigated in etiology and association with certain gastrointestinal pathologies have been well documented...
  17. ncbi Management of corrosive injuries of the upper gastrointestinal tract. Our experience in 58 patients
    U Robustelli
    A Cardarelli Hospital, Naples, Italy
    G Chir 32:188-93. 2011
    ..The ingestion of caustic substances is one of the most difficult conditions to be treated in Emergency Department...
  18. ncbi Interaction of Helicobacter pylori infection and low-dose aspirin in the upper gastrointestinal tract: implications for clinical practice
    En Ling Leung Ki
    Department of Medicine and Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, S A R, PR China
    Best Pract Res Clin Gastroenterol 26:163-72. 2012
    Low-dose aspirin has been shown to increase the risk of upper gastrointestinal tract injury...
  19. ncbi Clinical outcomes, quality of life, advantages and disadvantages of metal stent placement in the upper gastrointestinal tract
    Panagiotis Vlavianos
    Imperial College Healthcare Trust, London, UK
    Curr Opin Support Palliat Care 6:27-32. 2012
    ..Over recent years, indications such as benign disease have expanded, as has SEMS diversity with self-expandable plastic stents (SEPSs) or fully covered and biodegradable stents, for example...
  20. ncbi Medication-induced upper gastrointestinal tract injury
    Z Chen
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Clin Pathol 62:113-9. 2009
    ....
  21. ncbi Risk of upper gastrointestinal complications among users of traditional NSAIDs and COXIBs in the general population
    Luis A Garcia Rodriguez
    Centro Español de Investigación Farmacoepidemiológica CEIFE, Madrid, Spain
    Gastroenterology 132:498-506. 2007
    ..Whether use of selective inhibitors of cyclooxygenase-2 (COXIBs) will translate into a clinically relevant reduced toxicity has not been widely investigated in the general population...
  22. ncbi Macrophage migration inhibitory factor (MIF) -173G/C promoter polymorphism influences upper gastrointestinal tract involvement and disease activity in patients with Crohn's disease
    Julia Dambacher
    Department of Medicine II Grosshadern, University of Munich, Munich, Germany
    Inflamm Bowel Dis 13:71-82. 2007
    ..The aim of the study was to analyze the role of the MIF -173G/C single nucleotide polymorphism in Crohn's disease (CD)...
  23. ncbi Epidemiology of acute upper gastrointestinal bleeding
    M E van Leerdam
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center s, Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Best Pract Res Clin Gastroenterol 22:209-24. 2008
    ..H. pylori infection is found in about 50% of peptic ulcer bleeding patients. H. pylori should be tested for in all ulcer patients and eradication should be given...
  24. ncbi Clinical evaluation and management of caustic injury in the upper gastrointestinal tract in 95 adult patients in an urban medical center
    Gen Tohda
    Department of Surgery, Wayne State University, 6C UHC, 4201 St Antoine, Detroit, MI 48201, USA
    Surg Endosc 22:1119-25. 2008
    ..This retrospective study of adult patients with caustic injury presents the endoscopic findings, treatment regimen, and clinical outcome...
  25. ncbi Removal of a foreign body from the upper gastrointestinal tract with a flexible endoscope: a prospective study
    D M Chaves
    Endoscopy Service, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Endoscopy 36:887-92. 2004
    ..far been no prospective studies on the value of flexible endoscopy for removing foreign bodies in the upper gastrointestinal tract. This study presents a clinical analysis of accidents with foreign bodies and prospectively evaluates ..
  26. pmc Corrosive injury to upper gastrointestinal tract: Still a major surgical dilemma
    Siew Min Keh
    The Royal National Nose, Throat and Ear Hospital, London, WC1X 8DA, United Kingdom
    World J Gastroenterol 12:5223-8. 2006
    ..In this article, we present our experience of two contrasting cases of corrosive injury to the upper gastrointestinal tract in our thoracic unit in the last 2 years and an up-to-date Medline literature search has been carried ..
  27. ncbi Stenting of the upper gastrointestinal tract: current status
    Konstantinos Katsanos
    Department of Interventional Radiology, School of Medicine, Patras University Hospital, 26500 Patras, Greece
    Cardiovasc Intervent Radiol 33:690-705. 2010
    Minimally invasive image-guided insertion of self-expanding metal stents in the upper gastrointestinal tract is the current treatment of choice for palliation of malignant esophageal or gastroduodenal outlet obstructions...
  28. ncbi Study of the physicochemical and biological stability of pediocin PA-1 in the upper gastrointestinal tract conditions using a dynamic in vitro model
    E Kheadr
    STELA Dairy Research Center, Nutraceuticals and Functional Foods Institute, Pavillon des Services, University of Laval, Quebec, QC, Canada
    J Appl Microbiol 109:54-64. 2010
    ..To investigate the physicochemical and biological stability of purified pediocin PA-1 under GIT conditions...
  29. ncbi Xanthelasmas of the upper gastrointestinal tract
    Rasim Gencosmanoglu
    Unit of Surgery, Marmara University Institute of Gastroenterology, Basibuyuk, Maltepe, Istanbul, Turkey
    J Gastroenterol 39:215-9. 2004
    ..Gastric xanthelasma is a benign and uncommon lesion with a variably reported frequency, while esophageal and duodenal xanthelasmas are quite rare...
  30. ncbi Transcatheter arterial embolization of acute upper gastrointestinal tract bleeding with N-butyl-2-cyanoacrylate
    Chung Wei Lee
    Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, No 7, Chung Shan South Road, Taipei 100, Taiwan
    J Vasc Interv Radiol 18:209-16. 2007
    PURPOSEl: To retrospectively analyze outcomes in patients who received an iodized oil formulation of N-butyl-2-cyanoacrylate to treat acute nonvariceal upper gastrointestinal tract bleeding.
  31. ncbi Expression and nuclear localization of Snail, an E-cadherin repressor, in adenocarcinomas of the upper gastrointestinal tract
    Erika Rosivatz
    Institut fur Pathologie, Technische Universitat Munchen, Trogerstrasse 18, Munchen, Germany
    Virchows Arch 448:277-87. 2006
    ..Subsequently, a series of 340 adenocarcinomas of the upper gastrointestinal tract, including tumours from the oesophagus (n=154), cardia (n=102) and stomach (n=84), arranged in tissue ..
  32. ncbi Risk scoring systems to predict need for clinical intervention for patients with nonvariceal upper gastrointestinal tract bleeding
    I Chuan Chen
    Department of Emergency Medicine, Chang Gung Memorial Hospital, Puzih City, Chiayi County 613, Taiwan, ROC
    Am J Emerg Med 25:774-9. 2007
    ..Our study aims to compare Blatchford score with clinical Rockall score and complete Rockall score in their utilities in identifying high-risk cases in patients with acute nonvariceal UGIB...
  33. ncbi Survival of Lactobacillus rhamnosus strains in the upper gastrointestinal tract
    Iole Pitino
    DOFATA, Dipartimento di Orto Floro Arboricoltura e Tecnologie Agro Alimentari, University of Catania, Catania, Italy
    Food Microbiol 27:1121-7. 2010
    ..probiotic Lactobacillus rhamnosus strains were investigated for their ability to survive in the human upper gastrointestinal tract through a dynamic gastric model of digestion...
  34. ncbi Complications of endoscopy of the upper gastrointestinal tract: a single-center experience
    Herbert C Wolfsen
    Division of Gastroenterology and Hepatology, and Internal Medicine, Mayo Clinic College of Medicine, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    Mayo Clin Proc 79:1264-7. 2004
    To evaluate prospectively the complications that occurred during consecutive endoscopies of the upper gastrointestinal tract.
  35. ncbi Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes
    R L Young
    Discipline of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, Australia
    Gut 58:337-46. 2009
    ..These taste molecules are also present in the rodent small intestine, and may regulate gastrointestinal function...
  36. ncbi [Review of 209 cases of foreign bodies in the upper gastrointestinal tract and clinical factors for successful endoscopic removal]
    Jeong Ho Park
    Department of Internal Medicine, Chonnam National University College of Medicine, 8 Hak Dong, Dong Gu, Gwangju si 501 757, Korea
    Korean J Gastroenterol 43:226-33. 2004
    ..The aims of this study were to characterize the clinical features associated with foreign bodies in the upper gastrointestinal tract and to determine the clinical factors for their successful removal by endoscopic techniques.
  37. ncbi A randomized, placebo-controlled, 6-month study of once-weekly alendronate oral solution for postmenopausal osteoporosis
    Byron Cryer
    Division of Digestive Diseases, Dallas Veterans Affairs Medical Center, Dallas, Texas 75216, USA
    Am J Geriatr Pharmacother 3:127-36. 2005
    ..This study evaluated the overall safety and tolerability of once-weekly (OW) alendronate 70 mg oral solution (OS) versus OW placebo OS...
  38. ncbi Surgical therapy for gastrointestinal stromal tumours of the upper gastrointestinal tract
    Amitabha Das
    Department of Surgery, Bankstown Hospital, University of New South Wales, Eldridge Rd, Bankstown, New South Wales, 2200, Australia
    J Gastrointest Surg 13:1220-5. 2009
    This study aimed to examine clinicopathological features and outcomes after primary resection of gastrointestinal stromal tumours (GIST) of the upper gastrointestinal tract
  39. ncbi Endoscopic management of foreign bodies in the upper gastrointestinal tract in South China: a retrospective study of 561 cases
    Shenghong Zhang
    Division of Gastroenterology, The First Affiliated Hospital, Sun Yat Sen University, 510080 Guangzhou, Guangdong, People s Republic of China
    Dig Dis Sci 55:1305-12. 2010
    ..The aim of this study is to investigate the clinical features of FB ingestion in South China and report its management through endoscopy...
  40. ncbi Assessment of co-existence of Helicobacter pylori and Candida fungi in diseases of the upper gastrointestinal tract
    E Karczewska
    Department of Pharmaceutical Microbiology of the Jagiellonian University Medical College, Cracow, Poland
    J Physiol Pharmacol 60:33-9. 2009
    ..pylori. Analysis of relationship between selected disorders of the upper gastrointestinal tract (non ulcer dyspepsia NUD, gastric ulcer, duodenal ulcer) and infection with H...
  41. ncbi Safety and efficacy of a new high power argon plasma coagulation system (hp-APC) in lesions of the upper gastrointestinal tract
    H Manner
    Department of Internal Medicine II, HSK Wiesbaden, Ludwig Erhard Strasse 100, 65199 Wiesbaden, Germany
    Dig Liver Dis 38:471-8. 2006
    The aim of this study was to analyze safety and efficacy of a new high power argon plasma coagulation system in the upper gastrointestinal tract.
  42. ncbi Iron-induced mucosal injury to the upper gastrointestinal tract
    A Haig
    Department of Pathology, London Health Sciences Centre and University of Western Ontario, London, Ontario, Canada
    Histopathology 48:808-12. 2006
    ..To define the causes and associations of mucosal iron deposition in upper gastrointestinal biopsy specimens and to describe the morphological features of iron-related injury...
  43. ncbi Iron-induced mucosal pathology of the upper gastrointestinal tract: a common finding in patients on oral iron therapy
    P Kaye
    Department of Cellular Pathology, Nottingham University Hospitals and NHS Trust and University of Nottingham, Nottingham, UK
    Histopathology 53:311-7. 2008
    ..Upper gastrointestinal injury from iron tablets at therapeutic dose is not widely recognized. The aim was to document cases of iron-related upper gastrointestinal (GI) pathology and to determine frequency of occurrence...
  44. ncbi Endoscopic ultrasound of the upper gastrointestinal tract and mediastinum: diagnosis and therapy
    Priyajit Prasad
    Digestive Disease Center, Medical University of South Carolina, Charleston, SC, USA
    Cardiovasc Intervent Radiol 29:947-57. 2006
    ..Emerging investigational techniques include EUS-guided enteric anastomosis formation and fine-needle injection therapy for malignant disease...
  45. ncbi Use of a newly designed multifunctional coil catheter for stent placement in the upper gastrointestinal tract
    Ho Young Song
    Departments of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 388 1, Poongnap dong, Songpa Gu, Seoul, Korea
    J Vasc Interv Radiol 15:369-73. 2004
    To evaluate the usefulness of a newly designed multifunctional coil catheter for stent placement in patients with upper gastrointestinal tract strictures.
  46. ncbi Outcome of accident and emergency room triaged patients with low risk non-variceal upper gastrointestinal haemorrhage
    F Gleeson
    Gastrointestinal Unit, Mater Misericordiae University Hospital, Dublin, Ireland
    Ir Med J 99:114-7. 2006
    ..This highlights the need to initiate change, to monitor resource utilisation and implement early hospital discharge in appropriate patients...
  47. ncbi Management of acute upper gastrointestinal bleeding in a district hospital
    Abdul M Kasem
    Princess Royal University Hospital, Farnborough Common, United Kingdom
    J Laparoendosc Adv Surg Tech A 16:355-61. 2006
    ..This study was conducted to assess the management of acute upper gastrointestinal bleeding in a district hospital and to compare these results with national guidelines and the published literature...
  48. ncbi Process of care in acute nonvariceal upper-GI hemorrhage
    Gareth S Dulai
    Gastrointest Endosc 64:310-2. 2006
  49. ncbi Nonsteroidal anti-inflammatory drugs versus selective COX-2 inhibitors in the upper gastrointestinal tract
    Jurgen Scholmerich
    Klinik und Poliklinik für Innere Medizin I, Klinikum der Universitat Regensburg, D 93042 Regensburg, Germany
    J Cardiovasc Pharmacol 47:S67-71. 2006
    ..Considering the current controversy regarding cardiovascular events, there is no major reason to prefer coxibs to conventional NSAID plus PPI in patients needing long-term treatment...
  50. ncbi The importance of process issues as predictors of time to endoscopy in patients with acute upper-GI bleeding using the RUGBE data
    Eduardo B da Silveira
    Division of Gastroenterology, McGill University Health Centre, McGill University, Montreal, Quebec, Canada
    Gastrointest Endosc 64:299-309. 2006
    ..However, there is little information regarding clinical and process determinants that affect the time from onset of bleeding to performance of the endoscopy...
  51. ncbi [Magnifying endoscopy in upper gastrointestinal tract]
    Sang Ho Lee
    Department of Internal Medicine, Busan Medical Center, Busan, Korea
    Korean J Gastroenterol 48:145-55. 2006
    ..Futher studies then could be performed based upon consistent, validated, and standardized terminologies and criteria...
  52. ncbi Gastrointestinal endoscopic findings in men with unexplained anemia and low normal ferritin values
    Sa A Wang
    Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts, USA
    Am J Hematol 81:324-7. 2006
    ..The diagnostic yield of endoscopy in patients with anemia, no GI symptoms or signs, and low normal ferritin is not known...
  53. ncbi Unmet needs in non-steroidal anti-inflammatory drug-induced upper gastrointestinal diseases
    James M Scheiman
    Division of Gastroenterology, Department of Internal Medicine, School of Medicine, University of Michigan, Alfred Taubman Health Care Center, Ann Arbor 48109 0362, USA
    Drugs 66:15-21; discussion 29-33. 2006
    ..This article examines the current issues of understanding and managing NSAID-induced upper gastrointestinal diseases...
  54. ncbi Validation of administrative data used for the diagnosis of upper gastrointestinal events following nonsteroidal anti-inflammatory drug prescription
    N S Abraham
    Houston Center for Quality of Care and Utilization Studies, Section of Health Services Research, Houston, TX, USA
    Aliment Pharmacol Ther 24:299-306. 2006
    ..To validate veterans affairs (VA) administrative data for the diagnosis of nonsteroidal anti-inflammatory drug (NSAID)-related upper gastrointestinal events (UGIE) and to develop a diagnostic algorithm...
  55. ncbi Endoscopic findings in the upper gastrointestinal tract of faecal occult blood-positive, colonoscopy-negative patients
    K Hisamuddin
    Gastrointestinal and Liver Service, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
    Dig Liver Dis 38:503-7. 2006
    ..Detection of faecal occult blood is recommended for colorectal cancer screening in average risk populations. However, many subjects do not have any cause found in the colon to account for the occult blood loss...
  56. ncbi Laser therapy and surgical treatment in transfusion-dependent patients with upper-gastrointestinal vascular ectasia
    Lino Polese
    Department of Surgical and Gastroenterological Sciences, First Surgical Clinic, University of Padova, Padova, Italy
    Lasers Med Sci 21:140-6. 2006
    ....
  57. ncbi Upper GI foreign body: an adult urban emergency hospital experience
    W C Conway
    Departments of Surgery, Detroit Receiving Hospital and Wayne State University, MI 48201, USA
    Surg Endosc 21:455-60. 2007
    ..The efficacy of flexible endoscopy by a single endoscopist in the therapy of foreign body ingestion was assessed at an adult urban emergency hospital...
  58. ncbi Favorable prognosis of upper-gastrointestinal bleeding in 1041 older patients: results of a prospective multicenter study
    Stéphane Nahon
    Centre Hospitalier Montfermei, Montfermeil, France
    Clin Gastroenterol Hepatol 6:886-92. 2008
    ..Upper-gastrointestinal bleeding (UGIB) in the elderly is associated with high morbidity and mortality. The aims of this study were to determine the prognostic factors of UGIB in a large cohort of elders...
  59. ncbi Should every patient with suspected upper GI bleeding receive a proton pump inhibitor while awaiting endoscopy?
    A N Barkun
    Gastrointest Endosc 67:1064-6. 2008
  60. pmc Does blood urea nitrogen level predict severity and high-risk endoscopic lesions in patients with nonvariceal upper gastrointestinal bleeding?
    Khalid Al-Naamani
    Division of Gastroenterology, McGill University Health Centre, Montreal, Canada
    Can J Gastroenterol 22:399-403. 2008
    ..There are little or no data correlating sole blood urea nitrogen (BUN) level with the severity of nonvariceal UGIB or the presence of HRLs in the adult population...
  61. ncbi Cost-effectiveness analysis of high-dose omeprazole infusion before endoscopy for patients with upper-GI bleeding
    Kelvin K F Tsoi
    Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Gastrointest Endosc 67:1056-63. 2008
    ..The use of intravenous (i.v.) proton pump inhibitors (PPI) before an endoscopy in upper-GI bleeding (UGIB) was shown to reduce the need of endoscopic therapy and shorten hospital stay...
  62. ncbi ACR Appropriateness Criteria on treatment of acute nonvariceal gastrointestinal tract bleeding
    Steven F Millward
    University of Western Ontario, London, and Peterborough Regional Health Centre, Peterborough Ontario, Canada
    J Am Coll Radiol 5:550-4. 2008
    ..The choice of colonoscopy, TAI, or surgery for hemodynamically unstable patients with acute LGI bleeding will depend on institutional expertise and whether the site of bleeding has been localized...
  63. ncbi Usefulness of prognostic indices in upper gastrointestinal bleeding
    Robert James Atkinson
    Department of Gastroenterology and Endoscopy, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK
    Best Pract Res Clin Gastroenterol 22:233-42. 2008
    ..However, several indices are used to predict the outcome of advanced liver disease, including Child-Pugh and the Model of End-Stage Liver Disease (MELD). This chapter reviews all these aspects of the various scoring systems...
  64. ncbi Systematic review: tranexamic acid for upper gastrointestinal bleeding
    L L Gluud
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen, Denmark
    Aliment Pharmacol Ther 27:752-8. 2008
    ..Tranexamic acid may reduce upper gastrointestinal bleeding and stabilize patients before endoscopic treatments...
  65. ncbi Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding
    G I Leontiadis
    Department of Gastroenterology, Queen Elizabeth Hospital, Tyne and Wear, UK
    Health Technol Assess 11:iii-iv, 1-164. 2007
    ..Also to evaluate the clinical effectiveness of PPI therapy, compared with other treatments, for the prevention of subsequent bleeds in patients who had previously experienced peptic ulcer (PU) bleeding...
  66. ncbi [Long-term monitoring of patients with clinical symptoms of upper gastrointestinal tract bleeding with a negative endoscopy result]
    E Machytka
    Interní klinika FNsP Ostrava Poruba
    Vnitr Lek 53:942-6. 2007
    ..results of a long-term monitoring of patients who presented with clinical signs of bleeding from the upper gastrointestinal tract (GIT) but totally negative endoscopy results on admission...
  67. ncbi Endoscopic management of duodenal diverticular bleeding
    Yasuhiro Onozato
    Center of Gastroenterology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Gastrointest Endosc 66:1042-9. 2007
    ..Although the presence of a duodenal diverticulum is usually asymptomatic, bleeding in this tissue is sometimes difficult to diagnose and treat...
  68. ncbi [Foreign bodies in the upper gastrointestinal tract. Personal experience]
    M Zippi
    Struttura Complessa di Gastroenterologia ed Endoscopia Digestiva, Ospedale Sandro Pertini, Roma, Italia
    Clin Ter 158:291-5. 2007
    ..The majority of ingested foreign bodies pass spontaneously, but serious complications, such as bowel perforation and obstruction, can occur. In the present work, we report our experience in the management of ingested foreign bodies...
  69. ncbi Adherence to gastroprotection and the risk of NSAID-related upper gastrointestinal ulcers and haemorrhage
    E M van Soest
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Aliment Pharmacol Ther 26:265-75. 2007
    ..Upper gastrointestinal (UGI) complications are a well-recognized risk of NSAID treatment, requiring preventive measures in high-risk patients. Adherence to gastroprotective agents (GPAs) in NSAID users has been suggested to be suboptimal...
  70. ncbi Nonvariceal upper gastrointestinal bleeding
    Christopher J DiMaio
    Division of Digestive and Liver Diseases, Columbia University Medical Center, 630 West 168th Street, Box 83, New York, NY 10032, USA
    Gastrointest Endosc Clin N Am 17:253-72, v. 2007
    ..Attention also is given to medical management, risk assessment, and issues pertaining to the timing of endoscopy and need for scheduled second-look endoscopy...
  71. ncbi Membrane degradation of covered stents in the upper gastrointestinal tract: frequency and clinical significance
    Jin Hyoung Kim
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 388 1, Poongnap 2dong, Songpa Gu, Seoul 138 736, Republic of Korea
    J Vasc Interv Radiol 19:220-4. 2008
    ..To evaluate the frequency, clinical significance, and predictive factors of membrane degradation of covered stents in the upper gastrointestinal (UGI) tract...
  72. ncbi A prospective evaluation of 200 upper endoscopies performed in Alaska Native persons
    Frank Sacco
    Department of Surgery, Alaska Native Medical Center, Anchorage 99508, USA
    Int J Circumpolar Health 66:144-52. 2007
    ..To characterize the nature and prevalence of disease in Alaska Native patients referred for evaluation of upper gastrointestinal signs and symptoms...
  73. ncbi Back to basics--clinical diagnosis in bariatric surgery. Routine drains and upper GI series are unnecessary
    Ramsey M Dallal
    Albert Einstein Healthcare Network, Philadelphia, PA, USA
    Surg Endosc 21:2268-71. 2007
    ..The routine use of closed suction drains and upper GI (UGI) series has been used to aid in the diagnosis and management of gastrojejunal leak after gastric bypass as well as diagnose intra-abdominal bleeding...
  74. ncbi Endoscopic management of non-variceal upper gastrointestinal haemorrhage
    Vu Kwan
    Department of Gastroenterology, Concord Hospital, Sydney, New South Wales, Australia
    ANZ J Surg 77:222-30. 2007
    ..This review addresses the current status of endoscopic intervention for non-variceal upper gastrointestinal haemorrhage. Additionally, an overview of important periprocedural management issues is presented...
  75. pmc Acute upper gastrointestinal bleeding in octogenarians: clinical outcome and factors related to mortality
    George J Theocharis
    Division of Gastroenterology, Department of Internal Medicine, School of Medicine, University of Patras, Vironos 18, Patras 26224, Greece
    World J Gastroenterol 14:4047-53. 2008
    ..To evaluate the aetiology, clinical outcome and factors related to mortality of acute upper gastrointestinal bleeding (AUGIB) in octogenarians...
  76. ncbi Risk of serious upper gastrointestinal toxicity with over-the-counter nonaspirin nonsteroidal anti-inflammatory drugs
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Gastroenterology 129:1865-74. 2005
    ..Less is known about over-the-counter (OTC) NANSAIDs, which are typically used at lower doses and for shorter durations. This study assessed the risk of toxicity with OTC NANSAIDs...
  77. ncbi Upper gastrointestinal adverse drug reactions and cyclo-oxygenase-2 inhibitors (celecoxib and rofecoxib): a case/non-case study from the French Pharmacovigilance Database
    S Lugardon
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoépidémiologie et d Information sur le Médicament, Unité de Pharmacoépidémiologie, EA 3696, IFR 126, Faculte de Medecine, Toulouse, France
    Eur J Clin Pharmacol 60:673-7. 2004
    ..To evaluate the gastrointestinal safety of cyclo-oxygenase-2 inhibitors under their real conditions of use. DESIGN. Case/non-case study...
  78. ncbi Safety and tolerability of oral daily and intermittent ibandronate are not influenced by age
    Mark P Ettinger
    Radiant Research and Regional Osteoporosis Center of South Florida, 2081 SE Ocean Boulevard, Stuart, FL, USA
    J Rheumatol 32:1968-74. 2005
    ..We investigated the effect of age on the safety profile of oral daily and intermittent ibandronate, with particular emphasis on the upper gastrointestinal (GI) safety profile of ibandronate...
  79. ncbi Circulating ghrelin levels in patients with various upper gastrointestinal diseases
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Dig Dis Sci 50:833-8. 2005
    ..Further investigation is warranted to unravel the mechanisms of the high circulating ghrelin levels in certain upper gastrointestinal diseases...
  80. ncbi Prediction of UGIB event in NSAID users: a model development
    Mayuree Tangkiatkumjai
    Faculty of Pharmacy, Srinakharinwirot University, Nakhonnayok 26120, Thailand
    J Med Assoc Thai 88:672-7. 2005
    ..Antiulceration drug usage reduced the risk of UGIB in this group of patients. The developed model can be used as a guide for pharmacotherapeutic planning in clinical practices...
  81. ncbi Initial experience with laparoscopic bypass for upper gastrointestinal malignancy: a new option for palliation of patients with advanced upper gastrointestinal tumors
    Aamir Z Khan
    Department of General Surgery, Worthing Hospital, West Sussex, United Kingdom
    J Laparoendosc Adv Surg Tech A 15:374-8. 2005
    ..The aim of this study was to assess the safety and efficacy of laparoscopic bypass in patients with incurable UGI tract malignancy...
  82. ncbi Low utility of endoscopy for suspected upper gastrointestinal bleeding occurring in hospitalized patients
    Sripathi R Kethu
    Division of Gastroenterology, Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
    South Med J 98:170-5. 2005
    ..To determine the clinical utility of upper endoscopy in patients who have upper gastrointestinal bleeding after hospitalization...
  83. ncbi Prospective randomized trial for optimal prophylactic treatment of the upper gastrointestinal complications after open heart surgery
    Mitsumasa Hata
    Department of Cardiovascular Surgery, Nihon University School of Medicine, Tokyo, Japan
    Circ J 69:331-4. 2005
    ..Upper gastrointestinal bleeding is a lethal complication after open heart surgery. We designed a prospective randomized trial to test the efficacy of different antisecretory agents to prevent upper gastrointestinal disease after operation...
  84. ncbi Outcome of upper gastro-intestinal bleeding and use of ibuprofen versus paracetamol
    William J Blot
    International Epidemiology Institute, Rockville, Maryland, USA
    Pharm World Sci 26:319-23. 2004
    ..Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to increase the risk of upper gastrointestinal bleeding (UGIB). Whether the severity of outcome of UGIB associated with NSAIDs differs from non-NSAID-related UGIB is less clear...
  85. ncbi Endoscopic diagnosis and treatment of upper gastrointestinal tumors
    M Polkowski
    Dept of Gastroenterology, Medical Center for Postgraduate Education, Institute of Oncology, Roentgena 5, 02 781 Warsaw, Poland
    Endoscopy 36:847-54. 2004
  86. ncbi Lower gastrointestinal haemorrhage and superselective angiographic embolization
    Adele N Burgess
    Department of Surgery, Alfred Hospital, Melbourne, Prahran, Victoria 3181, Australia
    ANZ J Surg 74:635-8. 2004
    ..The outcome of this treatment remains, to some extent, an unknown. The present paper evaluates the Alfred Hospital's experience using superselective transcatheter embolization in the treatment of acute lower gastrointestinal haemorrhage...
  87. ncbi Routine second look endoscopy: ineffective, costly and potentially misleading
    Joseph Romagnuolo
    Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
    Can J Gastroenterol 18:401-4. 2004
    ..Finally, the Forrest classification may provide dangerously misleading estimates of prognosis because it is being used out of context. This review critically analyzes routine second look endoscopy...
  88. ncbi Upper gastrointestinal alarms in older people
    Neeraj Bhala
    Lancet 366:982-3. 2005
  89. ncbi [Clinical studies of pediatric malabsorption syndromes]
    Takashi Hosoyamada
    Department of Pediatrics Fukuoka Red Cross Hospital, Fukuoka, Japan
    Fukuoka Igaku Zasshi 97:322-50. 2006
    ..the subject had a lymphedematous right arm and hand, a grossly coarsened mucosal pattern of the upper gastrointestinal tract (identified via radiologic examination) and the presence of lymphangiectasia (confirmed via duodenal ..
  90. ncbi Cysteamine-colon and cysteamine-duodenum lesions in rats. Attenuation by gastric pentadecapeptide BPC 157, cimetidine, ranitidine, atropine, omeprazole, sulphasalazine and methylprednisolone
    P Sikiric
    Department of Pharmacology, Medical Faculty, University of Zagreb, Salata 11, POB 916 Zagreb, Croatia
    J Physiol Paris 95:261-70. 2001
    ..the ulcerogenic effect of cysteamine and protective effect of gastroduodenal antiulcer agents outside upper gastrointestinal tract (i.e. in colon). Intrarectal administration of the cysteamine (200 or 400 mg/kg b...
  91. ncbi Are twelve days of omeprazole, amoxicillin and clarithromycin better than six days for treating H. pylori infection in peptic ulcer and in non-ulcer dyspepsia?
    J P Gisbert
    Department of Gastroenterology, University Hospital of La Princesa, Madrid, Spain
    Hepatogastroenterology 48:1383-8. 2001
    ....
  92. ncbi Diagnosis and treatment of gastrinoma in the era of proton pump inhibitors
    Matthias Banasch
    Department of Medicine I, St Josef Hospital, University of Bochum, Bochum, Germany
    Wien Klin Wochenschr 119:573-8. 2007
    ..b>Upper gastrointestinal tract endoscopy will provide evidence for peptic ulcer disease in anatomical regions located aborally the ..
  93. ncbi [Use of sucrose permeability test (SaLM) for detection of lesions of upper gastrointestinal tract mucosa in upper dyspepsia patients--a pilot study]
    Norbert Cibicek
    Univerzita Karlova v Praze, Lekarska fakulta v Hradci Kralove
    Acta Medica (Hradec Kralove) Suppl 47:23-8. 2004
    ..So far there has been no available non-invasive test in the Czech Republic capable of distinguishing between heavy (i.e. peptic ulcer) and light (i.e. portal gastropathy) lesions of upper gastrointestinal mucosa...
  94. ncbi [Diagnostic role of upper gastrointestinal endoscopy in pediatric inflammatory bowel diseases]
    Tomasz Pytrus
    Akademia Medyczna we Wrocławiu, II Katedra i Klinika Pediatrii, Gastroenterologii i Zywienia
    Pol Merkur Lekarski 25:460-4. 2008
    To evaluate the frequency and type of endoscopic and histopathological changes in upper gastrointestinal tract in children with inflammatory bowel diseases.
  95. ncbi Prevalence of celiac disease, Helicobacter pylori and gastroesophageal reflux in patients with refractory iron deficiency anemia
    Soheir B Fayed
    Department of Pediatrics, Al Azhar, Cairo University and National Research Center, Cairo, Egypt
    J Trop Pediatr 54:43-53. 2008
    ..The aim of this article is to determine the prevalence of celiac disease (CD), Helicobacter pylori (H. pylori) and gastroesophageal reflux (GER) in patients with resistant iron deficiency anemia (IDA)...
  96. ncbi Microsporidia in the small intestine of HIV-infected patients. A new diagnostic technique and a new species
    A S Field
    St Vincent s Hospital, Darlinghurst, NSW
    Med J Aust 158:390-4. 1993
    ..To determine whether microsporidian infections occur in Australian patients infected with human immunodeficiency virus (HIV), to assess the incidence, and to discuss microscopic detection methods...
  97. ncbi Anthocyanins from red wine--their stability under simulated gastrointestinal digestion
    G J McDougall
    Quality, Health and Nutrition Programme, Genes to Products Theme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK
    Phytochemistry 66:2540-8. 2005
    ..assessed using an in vitro digestion system that simulated the physiochemical changes that occur in the upper gastrointestinal tract. Anthocyanins in red wine were stable to gastric conditions whereas there was a small loss in total ..
  98. ncbi [A case of the esophageal candidiasis supposedly caused by rhinenchysis steroid chronic administration before sleep]
    Hiroshi Shuto
    Kenshinkai Medical Corporation Ekibiru Clinic of Sengendai Station
    Arerugi 56:714-20. 2007
    ..dysphagia in the time of deglutition; pharyngitis and esophageal candidiasis were found by endoscopy of upper gastrointestinal tract.The interview after the endoscopy revealed that the patient, a 69-year-old female was diagnosed as ..
  99. ncbi Colonic catabolism of ellagitannins, ellagic acid, and raspberry anthocyanins: in vivo and in vitro studies
    Rocío González-Barrio
    Joseph Black Building, Centre for Population and Health Sciences, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Drug Metab Dispos 39:1680-8. 2011
    ..After ingestion of raspberries by humans, trace levels of anthocyanins, absorbed in the upper gastrointestinal tract, are excreted in urine in amounts corresponding to <0.1% of intake...
  100. pmc Importance of extensive staging in patients with mucosa-associated lymphoid tissue (MALT)-type lymphoma
    M Raderer
    Department of Internal Medicine I, University of Vienna, Austria
    Br J Cancer 83:454-7. 2000
    ..examination, otolaryngologic investigation, gastroscopy with multiple biopsies, endosonography of the upper gastrointestinal tract, enteroclysis, colonoscopy, computed tomography of thorax and abdomen and bone marrow biopsy...
  101. ncbi [Acute hemorrhage of the upper part of the gastrointestinal tract--survey of emergency endoscopy of the upper gastrointestinal tract at our facility]
    J Golánová
    Interni klinika 2 lékarské fakulty UK a FN Motol, Praha
    Vnitr Lek 50:274-7. 2004
    Acute upper gastrointestinal tract bleeding is a cause of significant morbidity and mortality and is a reason for urgent endoscopy...

Research Grants52

  1. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    James G Fujimoto; Fiscal Year: 2012
    ..If successful, the proposed research will develop and demonstrate new imaging technology which will augment gastrointestinal endoscopy and open the door for improved detection of a wide range of neoplasias. ..
  2. A Novel Colon-specific Bi-functional Amebicidal Therapeutics: Gal-Dextran-MM
    Jeoung Soo Lee; Fiscal Year: 2010
    ..This project is focused on development of a novel colon-specific bi-functional amebicidal therapeutic, Galactose-Dextran-Metronidazole (Gal-Dextran-MM) prodrug, for treatment of amebiasis. ..
  3. Oral Immunobiology of MCMV-infected Mouse Salivary Glands
    Steven D London; Fiscal Year: 2010
    ..plays an important role in host defense and is a major contributor of the innate host defense of the upper gastrointestinal tract. In addition, the salivary glands are a major component in the mucosal immune system of the oral cavity ..
  4. Biomarkers of Interoceptive Awareness in Adolescent Anorexia Nervosa
    NANCY L contact ZUCKER; Fiscal Year: 2010
    ....
  5. Fhit modulation of cell cycle progression and DNA damage response
    Kay Huebner; Fiscal Year: 2010
    ..cycle, DDR and apoptosis associated proteins in early oral and upper gastrointestinal tract lesions of Fhit-deficient mice before and after FHIT replacement by AdenoFHIT oral gene therapy...
  6. Ca2+ and secretory dynamics in salivary acinar cells
    David I Yule; Fiscal Year: 2013
    ..begins nutrient digestion and imparts antimicrobial and mechanical protection for the mouth and upper gastrointestinal tract. Reduced flow of saliva results in "dry mouth" (xerostomia) and greatly impacts the quality of life of ..
  7. Assessing feeding practices, immune activation, and HIV risk in African infants
    HEATHER BERYL JASPAN; Fiscal Year: 2013
    ..of non-breast milk liquids and solids alters the infant's mucosal or immunologic barriers of the upper gastrointestinal tract. This could lead to immune cell activation with an increase HIV target cells at the mucosa, or ..
  8. PHARMACOKINETICS AND PHARMACOLOGICAL EFFECTS OF ALCOHOL AFTER BARIATRIC SURGERY
    Marta Yanina Pepino; Fiscal Year: 2013
    ..responses to alcohol that occur as a result of the anatomical and physiological changes caused by upper gastrointestinal tract diversion might be an important mechanism responsible for the association between gastric bypass ..
  9. Oral microbial enzymes for the treatment of celiac disease
    EVA JOSEPHINE HELMERHORST; Fiscal Year: 2013
    ..The current application seeks to identify novel gluten-degrading enzymes expressed by resident microbes of the human upper gastrointestinal tract for their exploitation in the treatment of celiac disease.
  10. UPPER GI TRACT MEDIATION OF THE SATIETY EFFECT OF FATS
    Danielle Greenberg; Fiscal Year: 1992
    ..Those fat stimuli that are most effective for inducing satiety and those mechanisms that are found to mediate the satiety response in Sprague Dawley rats will be subsequently tested in identical paradigms in lean and obese Zucker rats...
  11. [Ca2+]i and Secretory Dynamics in Parotid Acinar Cells
    David Yule; Fiscal Year: 2007
    ..begins nutrient digestion and imparts antimicrobial and mechanical protection for the mouth and upper gastrointestinal tract. Reduced flow of saliva (xerostomia) greatly impact the quality of life of suffers...
  12. ORPHANIN FQ (OFQ) EFFECTS ON RAT COLONIC MOTILITY
    Toku Takahashi; Fiscal Year: 2003
    ..This may have important clinical implications since OFQ or its analogues may be beneficial for the treatment of refractory constipation in humans. ..
  13. UPPER GI TRACT MEDIATION OF THE SATIETY EFFECTS OF FATS
    James Gibbs; Fiscal Year: 1999
    ..The studies with the genetic models may provide a link between recent molecular biological advances and also provide potential pharmacological targets for new treatments of obesity and of the binge eating that occurs in bulimia. ..
  14. DEVELOPMENTAL ASPECTS OF UPPER GASTROINTESTINAL MOTILITY
    A Hillemeier; Fiscal Year: 1990
    ..examine the age related changes in mechanical properties and neurohumoral modulation of motility in the upper gastrointestinal tract. It will define the effect of developmental changes in shape, size, and geometry on the ability of the ..
  15. Apical CI/OH-/HCO3-exchanger in kidney and GI tract
    Manoocher Soleimani; Fiscal Year: 2007
    ..functional and molecular properties of PAT1 and apical CI-/HCO3- exchange in kidney proximal tubule and upper gastrointestinal tract in physiologic states and examination of PAT1 deficient mice should significantly enhance our ..
  16. EPITHELIAL RENEWAL IN PEPTIC AND NEOPLASTIC DISORDERS
    GREGORY EASTWOOD; Fiscal Year: 1980
    Changes in epithelial renewal may be important in the pathogenesis of mucosal disease of the upper gastrointestinal tract. We have shown in rats that aspirin ingestion over four weeks stimulates epithelial proliferation in the stomach, ..
  17. Gastrointestinal Response to Injury: Canada 2007
    Marshall Montrose; Fiscal Year: 2007
    ..of gastrointestinal mucosal defense in the colon and entire small intestine as well as the upper gastrointestinal tract. This format, as well as the location, enhanced the success of the series...
  18. GI Response to Injury: Canada 2004
    Sheila Crowe; Fiscal Year: 2004
    ..were applicable to investigation of gastrointestinal mucosal defense in the intestine as well as the upper gastrointestinal tract. The proposed meeting, "Gastrointestinal Response to Injury: Canada 2004", addresses important and ..
  19. Novel Optical Probe for Oral and Dental Tissue Screening
    Roger McNichols; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  20. ADVANCED MULTISPECTRAL IMAGING FOR MEDICAL DIAGNOSTICS
    Tuan Vo Dinh; Fiscal Year: 2005
    ..of real-time in vivo identification and characterization of malignant and pre-malignant tissues in the upper gastrointestinal tract. While presence of Barrett's mucosa is simple to detect endoscopically, at the present time dysplasia ..
  21. Brainstem nAChR Subtypes & Their Effect on GI Function
    RICHARD GILLIS; Fiscal Year: 2006
    ..These and future data obtained from pursuing our Specific Aims will extend current understanding of the different receptor mediated effects of nicotine on parasympathetic nervous system control of the upper GI tract. ..
  22. STABLE DERIVATIVES OF FECAPENTAENE
    LUKE LAM; Fiscal Year: 1993
    ..solve this problem by designing derivatives of fecapentaenes that will survive the environment of the upper gastrointestinal tract and allow the parent compounds to be released in the colon...
  23. Surveillance for Hepatocellular Carcinoma among HCV-infected Veterans
    Hashem El Serag; Fiscal Year: 2009
    ..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..
  24. Endoscopic Therapy of Early Cancer in Barretts Esophagus
    Kenneth Wang; Fiscal Year: 2009
    ..Diagnostic and therapeutic techniques developed in this study can be applied to other gastrointestinal tumors. ..
  25. METHYLATION PROFILING AND RISK OF COLORECTAL CANCER
    Hassan Ashktorab; Fiscal Year: 2007
    ..These studies will help in the detection and _rofiling of genetic changes in the pathway of CRC in AA. ..
  26. Immune Regulation by Gadd45b and Gadd45g
    Binfeng Lu; Fiscal Year: 2010
    ..Relevance: This study will lead to the development of novel strategies targeting these molecules to treat or prevent autoimmune diseases. This study will also reveal new disease markers for autoimmune diseases. ..
  27. PATHOGENESIS OF HEPATIC FIBROSIS AND PORTAL HYPERTENSION
    Don C Rockey; Fiscal Year: 2010
    ..These studies have direct relevance to human liver disease and will lead to new approaches for the treatment of hepatic fibrosis and portal hypertension as well as other forms of fibrosing injury. ..
  28. Assessment of Infant Outcomes After in Utero Exposure to Antiretroviral Therapy
    Sonia Hernandez diaz; Fiscal Year: 2010
    ..We propose to evaluate the risk of congenital malformations and other adverse pregnancy outcomes following antenatal exposure to ART in a prospective cohort of pregnant women. ..
  29. THE SINGAPORE COHORT STUDY OF DIET AND CANCER
    Jian Min Yuan; Fiscal Year: 2009
    ....
  30. Non-Homeostatic Neural Controls of Food Intake
    Hans Rudolf Berthoud; Fiscal Year: 2010
    ..abstract_text> ..
  31. Biomarkers in Phototherapy of Barrett's Esophagus
    Kenneth K Wang; Fiscal Year: 2010
    ..These studies will provide an improved understanding regarding the response of Barrett's esophagus to ablation therapy. ..
  32. Imageable Mouse Models of Pancreatic Cancer
    Michael Bouvet; Fiscal Year: 2008
    ..Using such dual-colored imaging techniques, a better characterization of the tumor-host interactions in pancreatic cancer can be made. ..
  33. Gene Expression in Barrett's Esophagus
    Hashem El Serag; Fiscal Year: 2006
    ..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
  34. Nitric Oxide and the Liver
    Don Rockey; Fiscal Year: 2003
    ..The dates of the entire AASLD scientific meeting are November 3rd to November 5th. The participants will be invited speakers and attendees of the annual 2002 AASLD meeting. ..
  35. A NOVEL TECHNIQUE FOR SCREENING BARRETT'S ESOSPHAGUS
    Kenneth Wang; Fiscal Year: 2003
    ..signal from the "optical biopsy" which would distinguish normal and abnormal tissue in the upper gastrointestinal tract. Three proposed probe designs will be evaluated initially in the resected porcine esophagus and stomach ..
  36. FUNCTIONAL ORGANIZATION OF THE VAGAL-ENTERIC INTERFACE
    Hans Rudolf Berthoud; Fiscal Year: 2003
    ..abstract_text> ..
  37. RANK/NF-KappaB signaling in chondrogenesis
    BRENDAN BOYCE; Fiscal Year: 2003
    ....
  38. Mechanisms of Growth Inhibition by Helicobacter Pylor
    Hassan Ashktorab; Fiscal Year: 2003
    ..These studies will help to establish how bacteria can increase apoptosis possibly through generation of ROS and in specific circumstances this may alter one's risk of developing cancer. ..
  39. Effects of Acupuncture on Gastric Motility in Rats
    Toku Takahashi; Fiscal Year: 2004
    ..We will study whether acupuncture shortens the period of postoperative ileus in rats. This study would provide beneficial information for patients with gastroparesis and postoperative ileus. ..
  40. Randomized Trial of Rosiglitazone for Ulcerative Colitis
    James Lewis; Fiscal Year: 2005
    ..If our hypothesis is correct, this study will serve to establish that ligands for PPARg possess biological activity necessary to modulate the inflammatory response in the intact human colon. ..
  41. In Vivo Raman Spectroscopy of Barrett's Esophagus
    Louis Michel Wong Kee Song; Fiscal Year: 2005
    ..abstract_text> ..
  42. Colon Barrier Breakdown in the Elderly
    James Mullin; Fiscal Year: 2005
    ..Changes in membrane composition/fluidity are known to affect paracellular permeability in general, and tight junction proteins specifically. ..
  43. DIETARY FACTORS IN THE ETIOLOGY OF CANCER IN SHANGHAI
    Jian Min Yuan; Fiscal Year: 2006
    ..In all instances of diet-cancer investigations, relevant genes with potential modifying effects on the respective diet-cancer associations will be included in the investigations. ..
  44. Association of PPAR gamma ligands & colonic neoplasia
    James Lewis; Fiscal Year: 2006
    ..Our results will allow us to translate the existing in vitro and in vivo observations to the intact human colon and could lead to further chemoprevention strategies. ..
  45. Mammalian Lactoferrin Receptors: Structure and Function
    Bo Lonnerdal; Fiscal Year: 2007
    ..Overall, our understanding of the physiological significance of Lf and its receptor will be increased. ..
  46. Regulation of the MAP kinase pathway in the CD4+ T cells
    Binfeng Lu; Fiscal Year: 2007
    ..Aim 2. Study the role of GADD45 protein in mediating the activation of the p38/JNK MAP kinase pathway by cytokines. Aim 3. Study the effect of mutation of GADD45gamma, GADD45beta, or MEKK4 in murine collagen induced arthritis. ..
  47. 2007 Bones and Teeth Gordon Research Conference
    BRENDAN BOYCE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  48. Regulation of Stellate Cell Contractility
    Don Rockey; Fiscal Year: 2008
    ..Physiologic endpoints will be an important focus. The proposed studies will shed light on the molecular basis of stellate cell contractility and moreover have direct relevance to human liver disease. ..
  49. Dietary Factors in the Etiology of Colorectal Cancer
    Jian Min Yuan; Fiscal Year: 2008
    ..The potential modifying effects of HAA activating genes and tea polyphenols on the HAA-colorectal cancer association will be explored. [unreadable] [unreadable]..
  50. Novel Method of Surveillance in Barrett's Esophagus
    Kenneth Wang; Fiscal Year: 2008
    ..This is an innovative method by which a physician can diagnose hidden areas of cancer within patients who are at a high risk of developing esophageal cancer. [unreadable] [unreadable] [unreadable]..
  51. PROSPECTIVE COMPARISON OF COLONIC IMAGING TEST
    Don Rockey; Fiscal Year: 2001
    ..The information gained from this study is expected to form the basis for national policy and decision making with reward to colonic imaging tests. ..