jejunum

Summary

Summary: The middle portion of the SMALL INTESTINE, between DUODENUM and ILEUM. It represents about 2/5 of the remaining portion of the small intestine below duodenum.

Top Publications

  1. ncbi Cholinomimetic and calcium channel blocking activities of Carthamus oxycantha
    Anwar H Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Phytother Res 19:679-83. 2005
  2. ncbi Telocytes, a distinct type of cell among the stromal cells present in the lamina propria of jejunum
    D Cretoiu
    Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    Histol Histopathol 27:1067-78. 2012
  3. ncbi Fusarium mycotoxin-contaminated wheat containing deoxynivalenol alters the gene expression in the liver and the jejunum of broilers
    B Dietrich
    Nutrition Biology, Institute of Agricultural Sciences, Swiss Federal Institute of Technology ETHZ, Universitatsstrasse 2, CH 8092 Zurich, Switzerland
    Animal 6:278-91. 2012
  4. ncbi Cytoskeleton remodeling and alterations in smooth muscle contractility in the bovine jejunum during nematode infection
    Robert W Li
    Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, USDA ARS, Beltsville, MD 20705, USA
    Funct Integr Genomics 12:35-44. 2012
  5. ncbi Modulation of intestinal P-glycoprotein function by cremophor EL and other surfactants by an in vitro diffusion chamber method using the isolated rat intestinal membranes
    Yasushi Shono
    Department of Biopharmaceutics, Kyoto Pharmaceutical University, Misasagi Yamashina ku, Kyoto 607 8414 Japan
    J Pharm Sci 93:877-85. 2004
  6. ncbi Fumonisin B1 exposure and its selective effect on porcine jejunal segment: sphingolipids, glycolipids and trans-epithelial passage disturbance
    Nicolas Loiseau
    Laboratoire de Pharmacologie et Toxicologie UR66, INRA, F 31931 Toulouse, France
    Biochem Pharmacol 74:144-52. 2007
  7. ncbi Characterization of myenteric neuropathy in the jejunum of spontaneously diabetic BB-rats
    M Zandecki
    Center for Gastroenterological Research, Catholic University Leuven, Leuven, Belgium
    Neurogastroenterol Motil 20:818-28. 2008
  8. pmc Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na+ channel, Nav1.5
    Peter R Strege
    Enteric Neuroscience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Gastrointest Liver Physiol 300:G1105-14. 2011
  9. ncbi Nitric oxide induces HIF-1α stabilization and expression of intestinal trefoil factor in the damaged rat jejunum and modulates ulcer healing
    A Riaño
    Department of Pharmacology and CIBERehd, Faculty of Medicine, University of Valencia, Avda Blasco Ibáñez 15 17, 46010 Valencia, Spain
    J Gastroenterol 46:565-76. 2011
  10. ncbi Genistein stimulates electrogenic Cl- secretion via phosphodiesterase modulation in the mouse jejunum
    Pin Chun Chao
    Dept of Physiology, School of Medical Sciences, Univ of Otago, P O Box 913, Dunedin, New Zealand
    Am J Physiol Cell Physiol 297:C688-98. 2009

Detail Information

Publications349 found, 100 shown here

  1. ncbi Cholinomimetic and calcium channel blocking activities of Carthamus oxycantha
    Anwar H Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    Phytother Res 19:679-83. 2005
    ..In spontaneously contracting rabbit jejunum preparations, Co.Cr caused a dose-dependent (0.03-3...
  2. ncbi Telocytes, a distinct type of cell among the stromal cells present in the lamina propria of jejunum
    D Cretoiu
    Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    Histol Histopathol 27:1067-78. 2012
    ..com). We show here direct electron microscopical evidence for the presence of TCs in the lamina propria of rat jejunum just beneath the epithelial layer of the mucosal crypts and in between the smooth muscle cells (SMCs) of ..
  3. ncbi Fusarium mycotoxin-contaminated wheat containing deoxynivalenol alters the gene expression in the liver and the jejunum of broilers
    B Dietrich
    Nutrition Biology, Institute of Agricultural Sciences, Swiss Federal Institute of Technology ETHZ, Universitatsstrasse 2, CH 8092 Zurich, Switzerland
    Animal 6:278-91. 2012
    ..05), and qPCR was performed on the liver and the jejunum to verify the results. No significant difference in BW, feed intake or feed conversion rate was observed...
  4. ncbi Cytoskeleton remodeling and alterations in smooth muscle contractility in the bovine jejunum during nematode infection
    Robert W Li
    Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, USDA ARS, Beltsville, MD 20705, USA
    Funct Integr Genomics 12:35-44. 2012
    ..and actin cytoskeleton signaling were among the pathways most significantly impacted by infection in the bovine jejunum. Together, these data suggest that smooth muscle hypercontractility may be initiated as a result of a primary C...
  5. ncbi Modulation of intestinal P-glycoprotein function by cremophor EL and other surfactants by an in vitro diffusion chamber method using the isolated rat intestinal membranes
    Yasushi Shono
    Department of Biopharmaceutics, Kyoto Pharmaceutical University, Misasagi Yamashina ku, Kyoto 607 8414 Japan
    J Pharm Sci 93:877-85. 2004
    ..than its mucosal-to-serosal transport (Jms), suggesting that the net movement of rhodamine123 across the rat jejunum was preferentially secretory direction...
  6. ncbi Fumonisin B1 exposure and its selective effect on porcine jejunal segment: sphingolipids, glycolipids and trans-epithelial passage disturbance
    Nicolas Loiseau
    Laboratoire de Pharmacologie et Toxicologie UR66, INRA, F 31931 Toulouse, France
    Biochem Pharmacol 74:144-52. 2007
    ..ratio of sphinganine to sphingosine, as well as alterations of the glycolipid distribution were observed in the jejunum. Using a porcine intestinal epithelial cell line (IPEC-1) derived from jejunum and ileum, we tested the effect of ..
  7. ncbi Characterization of myenteric neuropathy in the jejunum of spontaneously diabetic BB-rats
    M Zandecki
    Center for Gastroenterological Research, Catholic University Leuven, Leuven, Belgium
    Neurogastroenterol Motil 20:818-28. 2008
    ..In the jejunum of spontaneously diabetic rats, decreased nitric oxide responsiveness and decreased nNOS protein expression occur ..
  8. pmc Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na+ channel, Nav1.5
    Peter R Strege
    Enteric Neuroscience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Gastrointest Liver Physiol 300:G1105-14. 2011
    ..5, a voltage-dependent sodium channel expressed in the gastrointestinal tract in human jejunum smooth muscle cells and interstitial cells of Cajal, and to elucidate whether H(2)S acts on Na(V)1...
  9. ncbi Nitric oxide induces HIF-1α stabilization and expression of intestinal trefoil factor in the damaged rat jejunum and modulates ulcer healing
    A Riaño
    Department of Pharmacology and CIBERehd, Faculty of Medicine, University of Valencia, Avda Blasco Ibáñez 15 17, 46010 Valencia, Spain
    J Gastroenterol 46:565-76. 2011
    ..Nitric oxide modulates HIF-1 activity. The present study aims to analyze the role of nitric oxide in jejunum damage induced by indomethacin and its ability to modulate epithelial function through the expression of ITF.
  10. ncbi Genistein stimulates electrogenic Cl- secretion via phosphodiesterase modulation in the mouse jejunum
    Pin Chun Chao
    Dept of Physiology, School of Medical Sciences, Univ of Otago, P O Box 913, Dunedin, New Zealand
    Am J Physiol Cell Physiol 297:C688-98. 2009
    Previously, we demonstrated that genistein stimulated Cl(-) secretion in the mouse jejunum (Baker MJ and Hamilton KL, Am J Physiol Cell Physiol 287: C1636-C1645, 2004); however, the mode of action of genistein still remains unclear...
  11. ncbi Effects of deoxynivalenol on general performance and electrophysiological properties of intestinal mucosa of broiler chickens
    W A Awad
    Institute of Nutrition, Department of Veterinary Public Health and Food Science, University of Veterinary Medicine, Veterinarplatz 1, A 1210 Vienna, Austria
    Poult Sci 83:1964-72. 2004
    ..The effect of DON on the electrophysiological parameters of the jejunum was studied in vitro using isolated gut mucosa in Ussing chambers...
  12. ncbi Differential miRNA expression in the mouse jejunum during garlic treatment of Eimeria papillata infections
    Saleh Al-Quraishy
    Department of Zoology, College of Science, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia
    Parasitol Res 109:387-94. 2011
    ..Real-time PCR confirms these effects of garlic in the jejunum of E. papillata-infected mice...
  13. pmc Early immune response following Salmonella enterica subspecies enterica serovar Typhimurium infection in porcine jejunal gut loops
    Francois Meurens
    Institut National de la Recherche Agronomique INRA, UR1282, Infectiologie Animale et Sante Publique, F 37380 Nouzilly Tours, France
    Vet Res 40:5. 2009
    ..Typhimurium. In the future, this knowledge should help in the development of improved prophylactic and therapeutic approaches against porcine intestinal S. Typhimurium infections...
  14. ncbi Effects of cafeteria diet on the jejunum in sedentary and physically trained rats
    Célia Regina Scoaris
    Department of Morphophysiological Sciences, State University of Maringa, Maringa, Parana, Brazil
    Nutrition 26:312-20. 2010
    ..The effects of a cafeteria diet on the small intestine were investigated in adult Wistar rats under sedentary conditions and after physical training...
  15. ncbi The gaseous mediator, hydrogen sulphide, inhibits in vitro motor patterns in the human, rat and mouse colon and jejunum
    D Gallego
    Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona UAB, Bellaterra, Barcelona, Spain
    Neurogastroenterol Motil 20:1306-16. 2008
    ..The aim of this study was to investigate the effect of this gas on intestinal segments from mouse jejunum and colon, and muscular strips from the human and rat colon...
  16. ncbi Pharmacological basis for the use of Fumaria indica in constipation and diarrhea
    Anwar H Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 96:585-9. 2005
    ..In spontaneously contracting rabbit jejunum, Fi.Cr (0.03-0.3 mg/mL) caused a mild spasmogenicity followed by relaxation at the higher doses...
  17. pmc Alanyl-glutamine and glutamine supplementation improves 5-fluorouracil-induced intestinal epithelium damage in vitro
    Manuel B Braga-Neto
    Institute of Biomedicine and Clinical Research Unit University Hospital, Federal University of Ceara, Fortaleza, Brazil
    Dig Dis Sci 53:2687-96. 2008
    ..05). These new findings support our earlier study on the benefit of oral glutamine in enhancing epithelial recovery after 5-FU challenge...
  18. ncbi Distinct chemical classes of medium-sized transient receptor potential channel vanilloid 1-immunoreactive dorsal root ganglion neurons innervate the adult mouse jejunum and colon
    L L Tan
    Department of Physiology, University of Melbourne, Parkville, Victoria 3010, Australia
    Neuroscience 156:334-43. 2008
    ..The spinal afferent innervation of mouse jejunum and distal colon was investigated with retrograde neuronal tracing and multi-label immunohistochemistry...
  19. ncbi Intracorporeal circular stapling esophagojejunostomy using the transorally inserted anvil (OrVil) after laparoscopic total gastrectomy
    Oh Jeong
    Department of Gastroenterologic Surgery, Chonnam National University Hwasun Hospital, 160, Ilsim Ri, Hwasun eup, Hwasun Gun, Jeollanam do, 519 809, Korea
    Surg Endosc 23:2624-30. 2009
    ..The authors report the newly developed reconstruction technique after LTG: intracorporeal circular stapling esophagojejunostomy using the transorally inserted anvil (OrVil; Covidien, Mansfield, MA, USA)...
  20. ncbi Development of a pig jejunal explant culture for studying the gastrointestinal toxicity of the mycotoxin deoxynivalenol: histopathological analysis
    Martine Kolf-Clauw
    Universite de Toulouse, Ecole Nationale Vétérinaire ENVT, 23 Chemin des Capelles, BP 87614, 31300 Toulouse Cedex 3, France
    Toxicol In Vitro 23:1580-4. 2009
    ..3mg DON/kg) based on morphological scores, and of 0.2 microM based on villi lengths. In conclusion, our data indicate that pig intestinal explants represent a relevant and sensitive model to investigate the effects of food contaminants...
  21. pmc Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine
    Tjalling Bosse
    GI Cell Biology, EN 720, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell Biol 26:9060-70. 2006
    Gata4, a member of the zinc finger family of GATA transcription factors, is highly expressed in duodenum and jejunum but is nearly undetectable in distal ileum of adult mice...
  22. ncbi Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats
    April D Strader
    Genome Research Institute, Department of Psychiatry, University of Cincinnati, 2071 E Galbraith Rd, Reading, OH 45237, USA
    Am J Physiol Endocrinol Metab 288:E447-53. 2005
    ..In this procedure, an isolated segment of ileum is transposed to the jejunum, resulting in an intestinal tract of normal length but an alteration in the normal distribution of endocrine ..
  23. ncbi The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo
    C Atuma
    Department of Physiology, Uppsala University, P.O. Box 572, SE-751 23 Uppsala, Sweden
    Am J Physiol Gastrointest Liver Physiol 280:G922-9. 2001
    ..layer was translucent and continuous; it was thickest in the colon (approximately 830 microm) and thinnest in the jejunum (approximately 123 microm)...
  24. ncbi Duodenal-jejunal bypass for the treatment of type 2 diabetes in patients with body mass index of 22-34 kg/m2: a report of 2 cases
    Ricardo V Cohen
    Center for Surgical Treatment of Morbid Obesity, Hospital São Camilo, Sao Paulo, Sao Paulo, Brazil
    Surg Obes Relat Dis 3:195-7. 2007
  25. ncbi The presence of cholinomimetic and calcium channel antagonist constituents in Piper betle Linn
    A H Gilani
    Department of Physiology and Pharmacology, The Aga Khan University Medical College, Karachi, Pakistan
    Phytother Res 14:436-42. 2000
    ..In isolated rabbit jejunum preparations Pb...
  26. ncbi Morphological changes of rat jejunum after whole body gamma-irradiation and their impact in biodosimetry
    D Driak
    Gynaecological Obstetric Clinic, University Hospital Bulovka, Prague, Czech Republic
    Physiol Res 57:475-9. 2008
    ..Wistar rats were randomly divided into 21 groups, 10 animals per group. Samples of the jejunum were taken 24, 48, 72, and 96 h after the whole-body gamma-irradiation with the doses of 1, 5, 10, 15, and 20 Gy, ..
  27. ncbi Is the pathobiology of chemotherapy-induced alimentary tract mucositis influenced by the type of mucotoxic drug administered?
    Richard M Logan
    Discipline of Oral Pathology, School of Dentistry, Faculty of Health Sciences, The University of Adelaide, North Terrace, Adelaide, SA 5005, Australia
    Cancer Chemother Pharmacol 63:239-51. 2009
    ..The aim of the present study was to determine whether the changes that occur in the AT are affected by the type of mucotoxic drug...
  28. ncbi Effects of sodium deoxycholate and sodium caprate on the transport of epirubicin in human intestinal epithelial Caco-2 cell layers and everted gut sacs of rats
    Y L Lo
    Department of Pharmacy, Chia Nan College of Pharmacy and Science, Tainan Hsien, Taiwan
    Biochem Pharmacol 59:665-72. 2000
    ..were investigated in both the human colon adenocarcinoma (Caco-2) cell line and the everted gut sacs of the rat jejunum and ileum...
  29. ncbi A modified method of laparoscopic side-to-side esophagojejunal anastomosis: report of 14 cases
    Wang Ziqiang
    General Surgery Department, South West Hospital, Chongqing 400038, China
    Surg Endosc 22:2091-4. 2008
    ..Although feasible, reconstruction through a small incision has several drawbacks. The authors therefore report a modified method of laparoscopic side-to-side esophagojejunal anastomosis developed at their hospital...
  30. ncbi Pharmacological basis for the medicinal use of ginger in gastrointestinal disorders
    Muhammad Nabeel Ghayur
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, 74800, Pakistan
    Dig Dis Sci 50:1889-97. 2005
    ..In addition, the presence of a spasmolytic constituent(s) of the calcium antagonist type may explain its use in hyperactive states of gut like colic and diarrhea...
  31. ncbi Suitability of isolated rat jejunum model for demonstration of complete absorption in humans for BCS-based biowaiver request
    Luka Peternel
    Sandoz Development Center Slovenia, Pharmaceutical and Biological Profiling, Lek Pharmaceuticals d d, 1526 Ljubljana, Slovenia
    J Pharm Sci 101:1436-49. 2012
    The objective of this study was to evaluate the suitability and acceptance criteria of isolated rat jejunum model for Biopharmaceutics Classification System (BCS)-permeability classification...
  32. ncbi A simple technique for performing laparoscopic purse-string suturing during circular stapling anastomosis
    Shuji Takiguchi
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka, 565 0876, Japan
    Surg Today 35:896-9. 2005
    ..The time for placement of the anvil averaged approximately 8 min. The ring formation following anastomosis was favorable in all patients. As a result, we consider our technique to be simple but very effective...
  33. ncbi Antimicrobial activity of lupulone against Clostridium perfringens in the chicken intestinal tract jejunum and caecum
    G R Siragusa
    Agricultural Research Service, United States Department of Agriculture, Poultry Microbiological Safety Research UnitRussell Research Center, Athens, GA, USA
    J Antimicrob Chemother 61:853-8. 2008
    ..Hop (Humulus lupulus) bitter acids are known to possess potent antimicrobial activity. Lupulone was evaluated for in vivo antimicrobial activity to inhibit C. perfringens in a chick gastrointestinal colonization model...
  34. ncbi Expression of CYP3A isoforms and P-glycoprotein in human stomach, jejunum and ileum
    Roberto Canaparo
    Department of Anatomy, Pharmacology and Forensic Medicine, Division of Pharmacology and Experimental Therapeutics, University of Torino, Torino, Italy
    Clin Exp Pharmacol Physiol 34:1138-44. 2007
    ..CYP3A7 and ABCB1 (P-gp) genes were quantified in five normal samples from the human stomach, seven from the jejunum and eight from the ileum by real-time reverse transcription-polymerase chain reaction and western blot analysis...
  35. ncbi alpha(1C) (Ca(V)1.2) L-type calcium channel mediates mechanosensitive calcium regulation
    Greg L Lyford
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Cell Physiol 283:C1001-8. 2002
    ..These data demonstrate mechanical regulation of calcium entry through molecularly identified L-type calcium channels in mammalian cells and suggest that the mechanosensitivity resides within the pore forming alpha(1C)-subunit...
  36. ncbi Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver
    David M Mutch
    Nutrient Bioavailability, Nestlé Research Center Vers Chez Les Blanc, Lausanne 26, Switzerland
    Am J Physiol Gastrointest Liver Physiol 291:G63-72. 2006
    ..h revealed that two- to threefold more genes responded significantly to quercetin in WT compared with KO in the jejunum, ileum, colon, and liver, suggesting that hepatic P450s mediate many of the biological effects of quercetin, such ..
  37. ncbi Conservative management of anastomotic leaks after 557 open gastric bypasses
    Attila Csendes
    Department of Surgery, University Hospital, Santiago, Chile
    Obes Surg 15:1252-6. 2005
    ..One of the most serious complications after gastric bypass is an anastomotic leak. In a prospective surgical protocol for the management of this complication, the authors determined the incidence of anastomotic leaks...
  38. ncbi Carbon monoxide activates human intestinal smooth muscle L-type Ca2+ channels through a nitric oxide-dependent mechanism
    Inja Lim
    Enteric Neuroscience Program, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 288:G7-14. 2005
    ..CO-induced NO production may explain the apparent discrepancy between the low affinity of guanylyl cyclase for CO and the robust cGMP production evoked by CO...
  39. ncbi Species differences in the prokinetic effects of ginger
    Muhammad Nabeel Ghayur
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Sind, Pakistan
    Int J Food Sci Nutr 57:65-73. 2006
    ..alkaloids, showed a spasmogenic effect in isolated guinea-pig ileum with 8-50 times more potency than in rabbit jejunum and ileum and rat stomach fundus and ileum...
  40. ncbi Voice restoration after circumferential pharyngolaryngectomy with free jejunum repair
    M Benazzo
    Clinica Otorinolaringoiatrica, , IRCCS Policlinico S. Matteo, Italy
    Eur Arch Otorhinolaryngol 258:173-6. 2001
    ..a Provox 2 type prosthesis and intensive speech therapy after circumferential pharyngolaryngectomy with free jejunum repair. No patient had operative or post-operative complications due to insertion of the prosthesis...
  41. ncbi Pharmacological basis for the medicinal use of psyllium husk (Ispaghula) in constipation and diarrhea
    Malik Hassan Mehmood
    Natural Product Research Division, Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi, 74800, Pakistan
    Dig Dis Sci 56:1460-71. 2011
    ..The objective of this study was to determine the pharmacological basis of the medicinal use of psyllium husk (Ispaghula) in gastrointestinal motility disorders...
  42. ncbi The jejunum of diarrhea-predominant irritable bowel syndrome shows molecular alterations in the tight junction signaling pathway that are associated with mucosal pathobiology and clinical manifestations
    Cristina Martinez
    Department of Gastroenterology, Digestive System Research Unit, Hospital Universitari Vall d Hebron, Institut de Recerca Vall d Hebron, Universitat Autònoma de Barcelona Departmento de Medicina, Barcelona, Spain
    Am J Gastroenterol 107:736-46. 2012
    ..The objective of this study was to determine the molecular events and mechanisms and the clinical role of upper small intestinal alterations...
  43. ncbi Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes
    Danna M Breen
    Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    Nat Med 18:950-5. 2012
    ..Duodenal-jejunal bypass surgery (DJB), an experimental surgical technique that excludes the duodenum and proximal jejunum from nutrient transit(1,2), lowers glucose concentrations in nonobese type 2 diabetic rats(2–5)...
  44. ncbi Enteroscopic cyanoacrylate sclerotherapy of jejunal and gallbladder varices in a patient with portal hypertension
    S Getzlaff
    Dept. of Gastroenterology, City Hospital, Ludwigshafen am Rhein (University of Mainz Medical School, Germany
    Endoscopy 33:462-4. 2001
    ..No clinical signs of gastrointestinal bleeding were observed during a follow-up period of seven months...
  45. ncbi Jejunum inflammation in obese and diabetic mice impairs enteric glucose detection and modifies nitric oxide release in the hypothalamus
    Thibaut Duparc
    Institut National de la Sante et de la Recherche Medicale INSERM, Toulouse, France
    Antioxid Redox Signal 14:415-23. 2011
    ..oxidative/nitric oxide (iNOS, IL-1β), and endoplasmic reticulum stress (CHOP, ATF4) genes expression in the jejunum. Although we could not exclude the importance of the hypothalamic inflammatory state in obese and diabetic mice, ..
  46. pmc Rotavirus infection is not associated with small intestinal fluid secretion in the adult mouse
    Shirin Kordasti
    Division of Molecular Virology, Medical Faculty, University of Linkoping, 581 85 Linkoping, Sweden
    J Virol 80:11355-61. 2006
    ..Altogether, these data suggest that rotavirus infection is not sufficient to stimulate chloride and water secretion from the small intestines of adult mice...
  47. ncbi Adenocarcinoma arising in a tubular duplication of the jejunum
    Nobuya Kusunoki
    Department of Surgery, Hyogo Prefectual Kaibara Hospital, 5208 1 Kaibara, Kaibara cho, Hikamigun, Hyogo 669 3395, Japan
    J Gastroenterol 38:781-5. 2003
    ..We describe a unique case of adenocarcinoma arising in a tubular duplication of the jejunum; this is the oldest patients in whom malignant tumor of alimentary tract duplication has been reported...
  48. ncbi Successful embolization therapy for bleeding from jejunal varices after choledochojejunostomy: report of a case
    Akitoshi Sasamoto
    Department of Surgery, Shizuoka Kosei Hospital, 23 Kitaban cho, Aoi ku, Shizuoka, 420 8623, Japan
    Surg Today 40:788-91. 2010
    ..Bleeding could not be controlled long-term by cholangioscopic sclerosing therapy. We finally stopped the bleeding by embolizing a jejunal vein to the afferent loop...
  49. ncbi Nanoparticles based on N-trimethylchitosan: evaluation of absorption properties using in vitro (Caco-2 cells) and ex vivo (excised rat jejunum) models
    Giuseppina Sandri
    Department of Pharmaceutical Chemistry, University of Pavia, Pavia, Italy
    Eur J Pharm Biopharm 65:68-77. 2007
    ..enhancement properties of nanoparticles were investigated in an in vitro Caco-2 cell model and an ex vivo rat jejunum model. The mucoadhesion of the nanosystems was evaluated using excised rat jejunum...
  50. ncbi Clotrimazole-sensitive K+ currents regulate pacemaker activity in interstitial cells of Cajal
    Yaohui Zhu
    McMaster Univ, HSC 3N5C, 1200 Main St West, Hamilton, ON L8N 3Z5, Canada
    Am J Physiol Gastrointest Liver Physiol 292:G1715-25. 2007
    ..In summary, ICC generate a I(CTL) on depolarization through an intermediate-conductance calcium-activated K channel that regulates pacemaker activity and ICC excitability...
  51. ncbi Neurochemical and morphological phenotypes of vagal afferent neurons innervating the adult mouse jejunum
    L L Tan
    Department of Physiology, University of Melbourne, Parkville, Vic, Australia
    Neurogastroenterol Motil 21:994-1001. 2009
    ..upper gastrointestinal tract, the phenotypes of the different types of vagal afferent neurons innervating the jejunum is unknown...
  52. ncbi Tropical sprue is associated with contamination of small bowel with aerobic bacteria and reversible prolongation of orocecal transit time
    Uday C Ghoshal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 18:540-7. 2003
    ..In tropical sprue (TS), response to antibiotics may suggest a role for bacterial contamination of the small bowel, which is known in diseases with prolonged orocecal transit time (OCTT)...
  53. pmc A functional CFTR protein is required for mouse intestinal cAMP-, cGMP- and Ca(2+)-dependent HCO3- secretion
    U Seidler
    I Department of Medicine, Eberhard Karls Universitat Tubingen, Germany
    J Physiol 505:411-23. 1997
    ..now measured HCO3- secretion by pH-stat titration, and recorded the electrical parameters of in vitro duodenum, jejunum and ileum of mice deficient in the gene for the CFTR protein ('CF-mice') and their normal littermates. 2...
  54. ncbi The NANETS consensus guideline for the diagnosis and management of neuroendocrine tumors: well-differentiated neuroendocrine tumors of the Jejunum, Ileum, Appendix, and Cecum
    J Philip Boudreaux
    Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Pancreas 39:753-66. 2010
    Well-differentiated neuroendocrine tumors (NETs) of the jejunum, ileum, and appendix are also collectively known as midgut carcinoids. Similar to NETs in general, the diagnosed incidence of the midgut NETs is on the rise...
  55. pmc Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease
    Francesco Rubino
    IRCAD EITS European Institue of Telesurgery, Louis Pasteur University, Strasbourg, France
    Ann Surg 239:1-11. 2004
    ..The aim of this study was to investigate whether duodenal-jejunal exclusion can control diabetes independently on resolution of obesity-related abnormalities...
  56. pmc Comparison between cultured small-intestinal and fecal microbiotas in beagle dogs
    Silja Mentula
    Anaerobe Reference Laboratory, National Public Health Institute KTL, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Appl Environ Microbiol 71:4169-75. 2005
    ..In this study, we examined whether the organisms cultured from the jejunum and feces resemble each other...
  57. ncbi Eimeria papillata: upregulation of specific miRNA-species in the mouse jejunum
    Mohamed Dkhil
    Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
    Exp Parasitol 127:581-6. 2011
    ..This was associated with a low inflammatory response of the jejunum of mice evidenced by histology, non-response of IL-1β mRNA, even slight downregulation of IL-6 mRNA, only slight ..
  58. ncbi ClC-2 is required for rapid restoration of epithelial tight junctions in ischemic-injured murine jejunum
    Prashant K Nighot
    Department of Clinical Science, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street Raleigh, NC 27606, USA
    Exp Cell Res 315:110-8. 2009
    ..The present study investigated mechanisms of intestinal barrier repair following ischemic injury in ClC-2(-/-) mice...
  59. ncbi HIV enteropathy: crypt stem and transit cell hyperproliferation induces villous atrophy in HIV/Microsporidia-infected jejunal mucosa
    Philip A Batman
    Department of Histopathology, Bradford Teaching Hospitals Foundation Trust, Bradford, UK
    AIDS 21:433-9. 2007
    ..The study aim was to analyse the kinetics of stem and transit cells in the crypts of jejunal mucosa infected with HIV and Microsporidia...
  60. ncbi Duodenal-jejunal exclusion improves glucose tolerance in the diabetic, Goto-Kakizaki rat by a GLP-1 receptor-mediated mechanism
    Tammy L Kindel
    Department of Pathology and Laboratory Medicine, Genome Research Institute, University of Cincinnati, 2180 E Galbraith Road, Cincinnati, OH, USA
    J Gastrointest Surg 13:1762-72. 2009
    ..We compared two procedures that increase distal small bowel stimulation, ileal interposition (IT), and duodenal-jejunal exclusion (DJE)...
  61. ncbi Comparison of clinical and functional outcomes and hospital costs following pharyngoesophageal reconstruction with the anterolateral thigh free flap versus the jejunal flap
    Peirong Yu
    Department of Plastic Surgery, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Plast Reconstr Surg 117:968-74. 2006
    ..Pharyngoesophageal defects are commonly reconstructed with free jejunal or fasciocutaneous flaps, with various outcomes, and a direct comparison is lacking...
  62. pmc Orexins control intestinal glucose transport by distinct neuronal, endocrine, and direct epithelial pathways
    Robert Ducroc
    Institut National de la Sante et de la Recherche Medicale U773, Centre de recherche Biomedicale Bichat Beaujon, 16 rue Henri Huchard, BP16, 75870 Paris Cedex 18, France
    Diabetes 56:2494-500. 2007
    ..Orexins are neuropeptides involved in energy homeostasis. We investigated the effect of orexin A (OxA) and orexin B (OxB) on intestinal glucose transport in the rat...
  63. ncbi Functional outcomes after circumferential pharyngoesophageal reconstruction
    Jan S Lewin
    Department of Head and Neck Surgery, Section of Speech Pathology and Audiology, M D Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
    Laryngoscope 115:1266-71. 2005
    ..To determine functional speech and swallowing outcomes, morbidity, and complication rates after reconstruction of circumferential pharyngoesophageal defects using a jejunal versus an anterolateral thigh (ALT) flap...
  64. ncbi Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction
    J Wheatcroft
    Wolfson Digestive Diseases Centre, University Hospital, Nottingham, UK
    Neurogastroenterol Motil 17:863-70. 2005
    ..Thus infection induced inflammation increases EC numbers, as has been reported in PI-IBS, and reduces SERT. This may increase mucosal 5HT availability and contribute to the clinical presentation of PI-IBS...
  65. ncbi Isolation and characterization of a putative intestinal stem cell fraction from mouse jejunum
    Christopher M Dekaney
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Gastroenterology 129:1567-80. 2005
    ..Therefore, the aim of this study was to explore the hypothesis that viable intestinal stem cells can be isolated as a side population (SP) by fluorescence-activated cell sorting after staining with the DNA-binding dye Hoechst 33342...
  66. pmc Antispasmodic and vasodilator activities of Morinda citrifolia root extract are mediated through blockade of voltage dependent calcium channels
    Anwarul Hassan Gilani
    Natural Product Research Division, Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi, Pakistan
    BMC Complement Altern Med 10:2. 2010
    ..The objective of this study was to explore the possible mode(s) of action for its antispasmodic, vasodilator and cardio-suppressant effects to rationalize its medicinal use in gut and cardiovascular disorders...
  67. ncbi Pharmacological basis for the medicinal use of black pepper and piperine in gastrointestinal disorders
    Malik Hassan Mehmood
    Natural Product Research Division, Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi, Pakistan
    J Med Food 13:1086-96. 2010
    ..In rabbit jejunum, Pn.Cr (0.01–3...
  68. ncbi The expression of PPAR-associated genes is modulated through postnatal development of PPAR subtypes in the small intestine
    K Mochizuki
    Department of Nutrition, School of Food and Nutritional Sciences, University of Shizuoka, Japan
    Biochim Biophys Acta 1531:68-76. 2001
    ..mRNA level of peroxisome proliferator-activated receptor (PPAR) alpha, but not of PPARdelta, was elevated in the jejunum during the postnatal development of the rat...
  69. ncbi Proteins of interstitial cells of Cajal and intestinal smooth muscle, colocalized with caveolin-1
    Woo Jung Cho
    Department of Pharmacology, University of Alberta, 9 10 Medical Sciences Bldg, Edmonton, Alberta, Canada T6G 2H7
    Am J Physiol Gastrointest Liver Physiol 288:G571-85. 2005
    The murine jejunum and lower esophageal sphincter (LES) were examined to determine the locations of various signaling molecules and their colocalization with caveolin-1 and one another...
  70. ncbi Multiple efflux pumps are involved in the transepithelial transport of colchicine: combined effect of p-glycoprotein and multidrug resistance-associated protein 2 leads to decreased intestinal absorption throughout the entire small intestine
    Arik Dahan
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109 1065, USA
    Drug Metab Dispos 37:2028-36. 2009
    ..GF120918 significantly increased colchicine permeability in the ileum with no effect in the jejunum, whereas MK571 augmented jejunal permeability without changing the ileal transport...
  71. ncbi Intracorporeal circular-stapled esophagojejunostomy using hand-sewn purse-string suture after laparoscopic total gastrectomy
    Takahiro Kinoshita
    Department of Surgery, Toho University Sakura Medical Center, Shimoshizu 564 1, Sakura, 285 8741, Chiba, Japan
    Surg Endosc 24:2908-12. 2010
    ..The authors report a circular-stapled anastomosis using hand-sewn purse-string sutures, which is a simple and classic method. However, no previous study has assessed its reliability...
  72. ncbi Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resection in mice
    Christopher M Dekaney
    Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7223, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1013-22. 2007
    ..This was assessed in the jejunum of mice 2-3 days, 4-5 days, 6-7 days, 2 wk, 6 wk, and 16 wk following ileocecal resection (ICR) or sham operation...
  73. ncbi Grapefruit juice and its constituents augment colchicine intestinal absorption: potential hazardous interaction and the role of p-glycoprotein
    Arik Dahan
    College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan, 48109 1065, USA
    Pharm Res 26:883-92. 2009
    ..To investigate the potential interaction between grapefruit juice (GFJ) and the oral microtubule polymerization inhibitor colchicine, a P-gp and CYP3A4 substrate...
  74. pmc GATA4 is essential for jejunal function in mice
    Michele A Battle
    Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Gastroenterology 135:1676-1686.e1. 2008
    ..Although the zinc-finger transcription factor GATA4 has been implicated in regulating jejunal gene expression, the contribution of GATA4 in controlling jejunal physiology has not been addressed...
  75. ncbi Species differences in the gut stimulatory effects of radish seeds
    Muhammad Nabeel Ghayur
    Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Sind, Pakistan
    J Pharm Pharmacol 57:1493-501. 2005
    ..for terpenes, flavonoids, phenols, alkaloids and saponins, showed a spasmogenic effect in isolated rabbit jejunum and ileum, rat stomach fundus and ileum, and guinea-pig ileum and jejunum. Rs...
  76. ncbi Characterization of microbial populations and volatile fatty acid concentrations in the jejunum, ileum, and cecum of pigs weaned at 17 vs 24 days of age
    M A Franklin
    Department of Animal Science, University of Tennessee, Knoxville 37901 1071, USA
    J Anim Sci 80:2904-10. 2002
    ..matter percentage, aerobic and anaerobic microflora, lactate, and volatile fatty acid (VFA) concentrations in the jejunum, ileum, and cecum of weanling pigs...
  77. ncbi Surgical management of carcinoma of the hypopharynx and cervical esophagus: analysis of 209 cases
    J P Triboulet
    Service de Chirurgie Digestive et Generale, Clinique Chirurgicale Adultes Est, Chru Lille Hopital Huriez, Place de Verdun, 59037 Lille Cedex, France
    Arch Surg 136:1164-70. 2001
    ....
  78. pmc Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum
    Mar Guilarte
    Department of Medicine, Hospital Universitari General Vall d Hebron, 08035 Barcelona, Spain
    Gut 56:203-9. 2007
    ..Although upper gut symptoms are common, mast cells have not been thoroughly evaluated in proximal gut in IBS patients...
  79. ncbi Reconstruction of the hypopharynx after free jejunum flap failure: is a second free jejunum transfer feasible?
    Giulia Bertino
    Department of Otolaryngology Head Neck Surgery, University of Pavia, I R C C S Policlinico S Matteo Foundation, P le Golgi 2, 27100 Pavia, Italy
    Oral Oncol 44:61-4. 2008
    ..Despite the high reported success rates, the jejunum flap is still occasionally lost due to thrombosis of the pedicle and/or fistula formation...
  80. ncbi Functional results following pharyngolaryngooesophagectomy with free jejunal graft reconstruction
    G C Oniscu
    Department of Cardiothoracic Surgery, The Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh EH3 9YW, UK
    Eur J Cardiothorac Surg 19:406-10. 2001
    ..Our aim is to evaluate the postoperative outcome and functional results of the procedure...
  81. ncbi Roux-en-Y hepaticojejunostomy or hepaticoduodenostomy for biliary reconstruction during the surgical treatment of choledochal cyst: which is better?
    Akihiro Shimotakahara
    Department of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, 2 1 1 Hongo, 113 8421 Bunkyo ku, Tokyo, Japan
    Pediatr Surg Int 21:5-7. 2005
    ..3%) of complications due to duodenogastric bile reflux. Currently, RYHJ is our exclusive technique of choice for biliary reconstruction during the surgical repair of CC...
  82. pmc NADPH-diaphorase expression in the rat jejunum after intestinal ischemia/reperfusion
    A Bolekova
    Department of Anatomy, Pavol Jozef Safarik University, Kosice, Slokav Republic
    Eur J Histochem 55:e23. 2011
    ..study was to analyze the nicotinamide adenine dinucleotide phosphate - diaphorase (NADPH-d) activity in the rat jejunum after a mesenteric ischemia/reperfusion injury...
  83. pmc Percutaneous paraumbilical embolization as an unconventional and successful treatment for bleeding jejunal varices
    Lee Guan Lim
    Department of Gastroenterology and Hepatology, National University Hospital, 5 Lower Kent Ridge Road, 119074, Singapore 119074, Singapore
    World J Gastroenterol 15:3823-6. 2009
    ..Capsule endoscopy identified the bleeding site in the jejunum. Concurrently, CT angiography showed paraumbilical varices inseparable from a loop of small bowel, which had ..
  84. ncbi Enterohormonal changes after digestive adaptation: five-year results of a surgical proposal to treat obesity and associated diseases
    Sergio Santoro
    Department of Surgery, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    Obes Surg 18:17-26. 2008
    ..Recent physiological knowledge allows the design of bariatric procedures that aim at neuroendocrine changes instead of at restriction and malabsorption. Digestive adaptation is a surgical technique for obesity based in this rationale...
  85. ncbi Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum
    S Hatakeyama
    Department of Structural Pathology, Institute of Nephrology, Niigata University, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Biochem Biophys Res Commun 287:814-9. 2001
    ..protection assay and Northern blotting demonstrated almost exclusive expression of AQP10 mRNA in the duodenum and jejunum. In situ hybridization localized it in absorptive jejunal epithelial cells...
  86. ncbi Fluorescein transport properties across artificial lipid membranes, Caco-2 cell monolayers and rat jejunum
    Katja Berginc
    Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
    Eur J Pharm Biopharm 66:281-5. 2007
    ..permeability marker fluorescein were evaluated using artificial membrane, Caco-2 cell monolayers and rat jejunum, all mounted in side-by-side diffusion cells...
  87. ncbi Characterization of the effects of Enterococcus faecium on intestinal epithelial transport properties in piglets
    S Klingspor
    Institute of Veterinary Physiology, Department of Veterinary Medicine, Freie Universitat Berlin, 14163 Berlin, Germany
    J Anim Sci 91:1707-18. 2013
    ..faecium) changes the absorptive and secretory transport and barrier properties of piglet jejunum in vitro and thereby to verify tendencies observed in a former feeding trial with E. faecium...
  88. ncbi Changes in abundance of Lactobacillus spp. and Streptococcus suis in the stomach, jejunum and ileum of piglets after weaning
    Yong Su
    Laboratory of Gastrointestinal Microbiology, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China
    FEMS Microbiol Ecol 66:546-55. 2008
    ..and Streptococcus suis populations as potentially beneficial and harmful groups, in the stomach, jejunum and ileum of piglets after weaning (21 days postpartum) by 16S rRNA gene-based methods...
  89. pmc Hydrogen sulfide modulates contractile function in rat jejunum
    Michael S Kasparek
    Department of Surgery and Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55902, USA
    J Surg Res 175:234-42. 2012
    ..Effects of hydrogen sulfide (H(2)S), a third gasotransmitter of the gut, are not well understood. The aim of this study was to determine effects/mechanisms of H(2)S action on contractile function in rat jejunal muscle...
  90. ncbi Oesophageal substitution with free and pedicled jejunum: short- and long-term outcomes
    J A Cauchi
    Department of Paediatric Surgery, Birmingham Children s Hospital, Steelhouse Lane, Birmingham, B4 6NH, UK
    Pediatr Surg Int 23:11-9. 2007
    ..We present an outcome review of eight cases who underwent oesophageal substitution with jejunum at our institution between 1986 and 2001...
  91. ncbi Sequential release of milk protein-derived bioactive peptides in the jejunum in healthy humans
    Rachel Boutrou
    Institut National de la Recherche Agronomique INRA, joint research unit UMR 1253 Science et Technologie du Lait et de l Œuf, Rennes, France
    Am J Clin Nutr 97:1314-23. 2013
    ..The digestive hydrolysis of dietary proteins leads to the release of peptides in the intestinal tract, where they may exert a variety of functions, but their characterization and quantification are difficult...
  92. ncbi Dietary inulin affects the morphology but not the sodium-dependent glucose and glutamine transport in the jejunum of broilers
    H Rehman
    Institute of Nutrition, Department of Veterinary Public Health and Food Science, University of Veterinary Medicine, Veterinarplatz 1, A 1210 Vienna, Austria
    Poult Sci 86:118-22. 2007
    ..In conclusion, inulin supplementation affected the jejunal mucosal architecture but did not modify the electrogenic transport of Glc and amino acid under present experimental condition...
  93. ncbi Molecular morphology of the digestive tract; macromolecules and food allergens are transferred intact across the intestinal absorptive cells during the neonatal-suckling period
    Mamoru Fujita
    Graduate School of Health and Nutrition Sciences, Nakamura Gakuen University, 5 7 1 Befu, Jonan ku, Fukuoka 814 0198, Japan
    Med Mol Morphol 40:1-7. 2007
    ..allergens can be transferred intact with maternal immunoglobulins across the absorptive cells of duodenum and jejunum during the neonatal-suckling period...
  94. ncbi Factors predicting failure following high bilio-enteric anastomosis for post-cholecystectomy benign biliary strictures
    Biju Pottakkat
    Department of Surgical Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareli Road, Lucknow, 226014, UP, India
    J Gastrointest Surg 14:1389-94. 2010
    ..This study was aimed to find out the factors predicting failure after surgical repair in patients with BBS...
  95. ncbi Esophageal reconstruction using a pedicled jejunum with microvascular augmentation
    Takushi Yasuda
    Department of Surgery, School of Medicine, Kinki University, Osaka Sayama, Japan
    Ann Thorac Cardiovasc Surg 17:103-9. 2011
    ..The usefulness of reconstruction with a pedicled jejunum has also been reported in recent years...
  96. ncbi Effects of feed-borne Fusarium mycotoxins and an organic mycotoxin adsorbent on immune cell dynamics in the jejunum of chickens infected with Eimeria maxima
    George N Girgis
    Department of Animal and Poultry Science, University of Guelph, Guelph, ON, Canada N1G 2W1
    Vet Immunol Immunopathol 138:218-23. 2010
    ..mycotoxins and a polymeric glucomannan mycotoxin adsorbent (GMA) on immune cell populations were studied in the jejunum of broiler breeder pullets using an Eimeria maxima infection model...
  97. ncbi Extrinsic afferent nerve sensitivity and enteric neurotransmission in murine jejunum in vitro
    Mario H Mueller
    Department of Surgery and 2Walter Brendel Institute of Surgical Research, Ludwig Maximilian s University, Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 297:G655-62. 2009
    ..multiunit afferent recordings were made in vitro from paravascular nerve bundles supplying the mouse jejunum. Intraluminal pressure and afferent nerve responses were recorded under control conditions and under four ..
  98. ncbi Somatostatin sst(2) receptors inhibit peristalsis in the rat and mouse jejunum
    Faiza Abdu
    Department of Biomedical Science, Alfred Denny Building, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    Am J Physiol Gastrointest Liver Physiol 282:G624-33. 2002
    ..ligands on intestinal peristalsis by studying migrating motor complexes (MMCs) in isolated segments of jejunum from rats, mice, and sst(2)-receptor knockout mice...
  99. pmc Insulin-loaded nanoparticles based on N-trimethyl chitosan: in vitro (Caco-2 model) and ex vivo (excised rat jejunum, duodenum, and ileum) evaluation of penetration enhancement properties
    Giuseppina Sandri
    Department of Pharmaceutical Chemistry, School of Pharmacy, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy
    AAPS PharmSciTech 11:362-71. 2010
    ..have been taken into account: an in vitro study (Caco-2 cells) and an ex vivo study (excised rat duodenum, jejunum, and ileum)...
  100. ncbi Roles of the jejunum and ileum in the first-pass effect as absorptive barriers for orally administered tacrolimus
    Masahiro Shimomura
    Department of Pharmacy, Kyoto University Hospital, Graduate School of Medicine, Sakyo ku, Kyoto, 606 8507, Japan
    J Surg Res 103:215-22. 2002
    ..In the present study, we investigated the respective contribution of the jejunum and ileum to the first-pass effect of tacrolimus in rats.
  101. pmc Jejunum free flap in hypopharynx reconstruction: case series
    Marco Benazzo
    Dept, of Otorhinolaryngology, University of Pavia, IRCCS Policlinico S, Matteo, Pavia, Italy
    BMC Cancer 2:13. 2002
    ..Historically, many techniques have been used in order to achieve a safe and functional reconstruction. Jejunum interposition is generally considered the best reconstructive technique.

Research Grants62

  1. Intestinal satiation in Roux-en-Y gastric bypass rats: brain mechanisms and sex d
    Thomas Alexander Lutz; Fiscal Year: 2013
    ..e., into the jejunum, thus leading to increased release of the gut hormones glucagon-like peptide 1 (GLP-1) and peptide tyrosine ..
  2. Claudin-2, Claudin-12 and Cadherin-17: Novel Targets of Vitamin D Action
    ANGELA R PORTA; Fiscal Year: 2011
    ..Proposed studies will examine (1) levels of these proteins in the duodenum, jejunum and ileum of vitamin D deficient mice and after 1,25(OH)2D3 administration, and (2) under conditions of high and ..
  3. Effect of Bariatric Surgery on Mechanisms of Type 2 Diabetes: The B2D Trial
    Philip R Schauer; Fiscal Year: 2013
    ..to reduce stomach capacity to 15-30 mls and bypassing the remaining stomach, duodenum and a small portion of the jejunum. We and others have shown that gastric bypass surgery has significant long-term effects on weight loss, the ..
  4. Circulating miRNA as a biomarker for biliary atresia
    Joshua R Friedman; Fiscal Year: 2013
    ..is the hepato-portoenterostomy procedure, in which the biliary remnants are excised and a Roux-en-Y limb of jejunum is placed in contiguity with the exposed liver surface at the porta hepatis...
  5. Understanding the role of bile as a mechanism for improved glucose homeostasis fo
    APRIL DAWN STRADER; Fiscal Year: 2010
    ..With this model a portion of the lower intestine, or ileum, is relocated into a region within the jejunum and is therefore prematurely exposed to higher concentrations of nutrients and biliopancreatic secretions...
  6. Nutritional and Hormonal Mechanisms of Intestinal Adaptation
    Denise M Ney; Fiscal Year: 2011
    ..Subepithelial myofibroblasts will be isolated from jejunum of IGFBP-3/-5 knockout mice and treated with GLP-2 to determine if reduced IGF-I expression (mRNA &peptide) ..
  7. Regulation of Intestinal Gene Expression
    Stephen D Krasinski; Fiscal Year: 2012
    ..regulator of jejunal-ileal differences in absorptive enterocyte gene expression using profiling analysis on the jejunum of conditional Gata4 null mice...
  8. NEURAL SUBSTRATES OF PEPTIDE INDUCED SATIETY
    Robert C Ritter; Fiscal Year: 2012
    ..by enteroendcrine "I cells" of the upper small intestine, while GLP-1 is secreted by the "L-cells" of the distal jejunum, ileum and colon...
  9. Protective role of creb-binding protein in maturation and aging
    Charles V Mobbs; Fiscal Year: 2011
    ..to assess mRNA of CBP and other transcription factors or histone acetylation in several brain areas liver, and jejunum from male and female mice at birth, and 1, 2, 3, and 4 weeks after birth;mice will be weaned either to a normal ..
  10. Feeding and Pancreatic Rest in Acute Pancreatitis
    DAVID CLEMENT WHITCOMB; Fiscal Year: 2012
    ..suggested that feeding could be optimized by the placement of specialized double-lumen feeding tubes in the mid-jejunum (40cm past the ligament of Treitz) by transnasal endsocopic techniques to bypass the compressed upper Gl tract, ..
  11. DRUG METABOLISM BY INTESTINAL FLAVIN MONOOXYGENASES
    ROSITA PROTEAU; Fiscal Year: 2001
    ..characterization of intestinal FMOs in human duodenum, jejunum, ileum, colon, and in continuous cell lines from intestinal and colonic origin will be investigated...
  12. Mucosal Cell Transporters and Enzymes for Enhancing Oral Drug Absorption
    Gordon L Amidon; Fiscal Year: 2013
    ..HeLa cells, transport permeability and activation in Caco-2 monolayers, and in vivo in the in situ perfused rat jejunum. Select at least 4 prodrugs for in vivo plasma level determination and bioavailability and pharmacokinetic ..
  13. C/EBP and IL-6 Production in Mucosa and Enterocytes
    Per Olof Hasselgren; Fiscal Year: 2006
    ..C/EBP activity is determined in mucosa from different regions of the gastrointestinal tract (stomach, jejunum, ileum and colon)...
  14. Determining the Mechanisms Regulating Functional Regionalization of the Intestine
    Michele A Battle; Fiscal Year: 2013
    ..Our preliminary studies have shown that loss of the zinc finger transcription factor GATA4 in the jejunum compromises jejunal identity and function suggesting that GATA4 plays a dominant role in conferring jejunal ..
  15. WATER AND ELECTROLYTE TRANSPORT BY THE INTESTINE
    KENNETH HUBEL; Fiscal Year: 1990
    ..neurons) reduces chloride absorption in human ileum and sigmoid colon, and causes secretion of chloride in jejunum and cecum...
  16. ABSORPTION, SECRETION, MALABSORPTION AND DIARRHEA
    JOHN FORDTRAN; Fiscal Year: 2002
    ..state intestinal perfusion which allows detailed examination of mucosal absorption or secretion rate in the jejunum, ileum and colon. Observations in patients often lead to research ideas in volunteers and vice versa...
  17. AMINO ACID TRANSPORT AFTER SMALL BOWEL RESECTION
    HARRY SAX; Fiscal Year: 2004
    ..EGF binding activates the EGF receptor (EGFR). In cell suspensions derived from both human jejunum and C2BBE1cell line, EGF increases glutamine transport, upregulation is blocked by tyrosine kinase inhibitors ..
  18. Absorption and Metabolism of Isoflavones
    Ming Hu; Fiscal Year: 2005
    ..The aims of this study are abbreviated as: (1) to determine region-dependent (i.e., duodenum, jejunum, ileum, and colon) hydrolysis of glycosides; (2) to determine the role played by glucose transporters in the ..
  19. NUTRITION SUPPORT EFFECT ON SEVERE ACUTE PANCREATITIS
    Stephen Martin; Fiscal Year: 1999
    ..Several studies have demonstrated safety of enteral feedings infused into the jejunum of patients with post operative paralytic ileus...
  20. FEEDBACK REGULATION OF PANCREATIC SECRETION
    Gary Green; Fiscal Year: 2000
    ..The regulation of LCRF secretion will be investigated in conscious rats with isolated Thiry-Vella Fistulas of jejunum by measuring the effects of nutrients, bile acids and neural blockade on the secretion of immunoreactive LCRF ..
  21. MOTILITY OF THE DIGESTIVE TRACT IN HEALTH AND DISEASE
    KEITH KELLY; Fiscal Year: 1993
    ..2) To determine whether pacing a loop of canine jejunum absorption...
  22. NEUROHORMONAL CONTROL OF INTESTINAL APOLIPOPROTEIN A IV
    Theodore Kalogeris; Fiscal Year: 2001
    ..in the ileum produces a signal which appears to act via the vagus nerve to stimulate synthesis of apo A-IV in the jejunum, and 2) this signal may be involved in the integrated response of apo A-IV to a fat meal...
  23. ACTIVATION OF CFTR MUTANTS IN VIVO FOR CF THERAPY
    MITCHELL DRUMM; Fiscal Year: 1999
    ..difference measurements will be made to examine transport in the airway and short circuit current across the jejunum measured in response to beta-adrenergic agonists and class-specific phosphodiesterase inhibitors...
  24. CFTR AND ALIMENTARY EPITHELIAL ACID/ BASE TRANSPORT
    Lane Clarke; Fiscal Year: 2000
    ..in the proximal duodenum, and 2) cAMP-induced inhibition of coupled Na+/H+, CL0/HCO3- exchange mechanisms in the jejunum. Furthermore, the reported location of these transport mechanisms suggest that CFTR expression is not only ..
  25. REGULATION OF INTESTINAL DEVELOPMENT
    SUSAN HENNING; Fiscal Year: 2002
    ..2) To develop a co-culture system using mesenchymal cells and epithelial cells from suckling rodent jejunum to allow ultimate testing of genes identified as putative mediators of GC action on the developing intestine...
  26. Engineering Insulin Production by K-Cells to Treat T1DM
    Burton Wice; Fiscal Year: 2004
    ..can be grafted onto synthetic biodegradable polymers instead of colonic muscle and then anastomosed into the jejunum where the grafts remain intact for >9 months...
  27. CRYPTOSPORIDIOSIS IN THE NORMAL AND IMMUNODEFICIENT
    Robert Argenzio; Fiscal Year: 1990
    ..In vivo perfusion studies of jejunum and ileum will determine alterations in mucosal permeability and quantify maldigestion/malabsorption components...
  28. NUTRIENT INDUCED GASTRIC PROTECTION--ROLE OF CCK
    David Mercer; Fiscal Year: 2000
    Cholecystokinin (CCK) is a gut peptide produced by CCK cells located in the duodenum and proximal jejunum. The major dietary intestinal stimuli for its release are intact proteins and fatty acids...
  29. Early Events in Diclofenac Enteropathy
    MARY MOSLEN; Fiscal Year: 2004
    ..A jejunum-to-jejunum anastamosis technique will assess alternative explanations for adduct accumulation at sites of ulcers...
  30. Is GIP Involved in the Resolution of Diabetes After Roux-en-y Gastric Bypass?
    Tammy Kindel; Fiscal Year: 2009
    ..yet to be elucidated, the surgical diversion of food from the duodenum with early delivery of nutrients to the jejunum appears to play a central role...
  31. REACTIONS OF HEAVY METALS WITH EPITHELIAL CELLS
    ERNEST FOULKES; Fiscal Year: 1991
    ..2) Step 1 of absorption, reaction of metals with brush border membranes, will be studied with everted sacs of rat jejunum. 3) Purified brush border membrane preparations; such vesicles will be useful for the study both of metal ..
  32. Protein Kinase A and Intestinal Pseudo-obstruction
    GEORGE MCKNIGHT; Fiscal Year: 2005
    ..In some cases the duodenum and proximal jejunum are specifically affected, while in other cases the ileum and proximal colon are selectively affected...
  33. ISOLATION OF THE INTESTINAL PHASE HORMONE
    MARSHALL ORLOFF; Fiscal Year: 1980
    ..hypersecretion by an endogenous substance (hormone) that arises in the small intestine, particularly in the jejunum. Moreover, our studies have demonstrated that this endogenous substance exists in humans as well as in dogs, rats ..
  34. MODULATION OF INTESTINAL OBESITY SIGNALS
    Patrick Tso; Fiscal Year: 2004
    ..relationship between the dose of lipid fed and the mRNA levels, synthesis and secretion of apo A-IV by the jejunum in animals fed chronically HF compared to low-fat (LF)...
  35. ENTERIC NEURON ABLATION; ALTERED MOTILITY AND SECRETION
    Paul Bass; Fiscal Year: 1990
    ..destroyed myenteric neurons by the application of chemicals with surfactant properties to the serosa of the rat jejunum. As a result of this surfactant treatment, myenteric neuronal function is lost as indicated by the lack of ..
  36. PROSTAGLANDINS AND GASTROINTESTINAL DNA DAMAGE
    Courtney Houchen; Fiscal Year: 2006
    ..AOM treatment resulted in marked apoptosis in crypt epithelial cells of the jejunum and distal colon within 8 h...
  37. DEVELOPMENT OF ORAL SWINE INFLUENZA VACCINE
    ANNE KRONIS; Fiscal Year: 2000
    ..In Phase 1 we expect to demonstrate that when the vaccine is administered directly into the jejunum, it stimulates both serum IgG and mucosal IgA antibody and prevents infection from a homologous swine influenza ..
  38. PARACELLULAR CALCIUM ABSORPTION--A NEW APPROACH
    David Lee; Fiscal Year: 2000
    ..will be complemented by in vitro transepithelial transport studies using natural epithelium from duodenum, jejunum, ileum, cecum, colon and monolayers of the IEC6, IEC18, T84 and Caco-2 cell lines...
  39. SURGICAL STUDIES OF INTESTINAL SEROTONIN
    John Kellum; Fiscal Year: 2005
    ..The two main models are rat distal colon and human proximal jejunum. Accordingly, the specific aims are to characterize 1) the mechanisms of 5-HT release from the mucosa, using ..
  40. The role of HNF4 in gastrointestinal development
    Michele Battle; Fiscal Year: 2006
    ..The effect of loss of HNF4 in the duodenum, the jejunum and ileum, and the transverse colon will be examined using a combination of histological, immunohistological, and ..
  41. MOTOR AND ELECTRICAL ACTIVITY OF THE ALIMENTARY CANAL
    CHARLES CODE; Fiscal Year: 1980
    ..the activity fronts, Phase III, which start in the stomach and duodenum from those which are initiated in the jejunum (ectopic fronts)...
  42. IN VITRO IMPEDANCE BIOASSAY FOR THE CF FACTOR
    Robert Tucker; Fiscal Year: 1980
    ..procedure, with which the authors have considerable experience, utilizes direct current measurements on rat jejunum to achieve a 90% accuracy in discerning between normal and CF genotypes; however, the assay is unable to ..
  43. Gut Ischemia/Reperfusion Injury: Modulation by Nutrients
    Rosemary Kozar; Fiscal Year: 2006
    ..The sponsors are an integral part of this arrangement and are especially suited to ensure success of the proposed project...
  44. Neonatal Bladder Inflammation, Opioids, and Adult Bladder Pain
    Alan Randich; Fiscal Year: 2010
    ....
  45. BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTES
    Ellen Ebert; Fiscal Year: 2002
    ..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..
  46. Early-In-Life Inflammation Effects on Urinary Bladder Sensation
    Alan Randich; Fiscal Year: 2009
    ..Translation to the treatment of painful bladder syndromes like 1C would be highly probable. ..
  47. ABCs of Intestinal Sterol Transport
    F Field; Fiscal Year: 2009
    ..The results of this proposal will provide new and novel information on the roles of the ABC transporters, NPC1L1, and lipid rafts in intestinal sterol metabolism ..
  48. Substance P in pathogenesis of cryptosporidiosis in AIDS
    Prema Robinson; Fiscal Year: 2004
    ..abstract_text> ..
  49. Effects of early-in-life bladder stimulation on adults
    Alan Randich; Fiscal Year: 2004
    ..Translation to the treatment of IC would be highly probable. ..
  50. Modulation of NHE Activity by EPEC Infection
    Pradeep Dudeja; Fiscal Year: 2006
    ..Our findings may aid in the future development of improved therapeutic modalities for infectious diarrhea. [unreadable] [unreadable] [unreadable]..
  51. MINIMAL ENTERAL NUTRIENT REQUIREMENTS IN NEONATES
    Douglas Burrin; Fiscal Year: 2004
    ....
  52. Neuropeptides in the pathogenesis of neurocysticercosis
    Prema Robinson; Fiscal Year: 2007
    ..abstract_text> ..
  53. BOLD Prediction of Success in a Weight Loss Program
    James Cox; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  54. Arginine and Ovine Model for Fetal Growth Restriction
    Guoyao Wu; Fiscal Year: 2007
    ..This will ultimately promote favorable pregnancy outcomes while saving billions of healthcare dollars in the U.S. and worldwide. [unreadable] [unreadable] [unreadable]..
  55. Effects of Acupuncture on Gastric Motility in Rats
    Toku Takahashi; Fiscal Year: 2004
    ..We will study whether acupuncture shortens the period of postoperative ileus in rats. This study would provide beneficial information for patients with gastroparesis and postoperative ileus. ..
  56. PRECONDITIONING: PMN ADHESION AND MICROVASCULAR INJURY
    RONALD KORTHUIS; Fiscal Year: 2003
    ....
  57. Role of Estrogen in Stimulated Water Intake
    Eric Krause; Fiscal Year: 2005
    ..By doing so, we will test the overall hypothesis that central interactions between estrogen and angiotensin II underlie the effect of estrogen on physiologically stimulated water intake. ..
  58. COMPLEMENT C3 AND ACQUIRED AND INNATE IMMUNITY
    Michael Carroll; Fiscal Year: 2003
    ..Furthermore, elucidation of the mechanism of complement activation of mast cells is important for defining this important effector function of natural immunity. ..
  59. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  60. IMMUNOBIOLOGY OF HIV-1 INFECTION IN MUCOSA
    Phillip Smith; Fiscal Year: 2007
    ..3) Determine whether intestinal (lamina propria)lymphocytes participate in the selection of the genotypic minor variant that characterizes the transmitted virus in acutely infected recipients. ..
  61. REDOX MECHANISMS OF RESPIRATORY MUSCLE STRESS ADAPTATION
    Thomas Clanton; Fiscal Year: 2009
    ..This basic science investigation will give new insights into fundamental skeletal muscle biology that will have applications to a variety of muscle disorders related to O2 transport limitation. ..