small intestine

Summary

Summary: The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.

Top Publications

  1. ncbi Identification of stem cells in small intestine and colon by marker gene Lgr5
    Nick Barker
    Hubrecht Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Nature 449:1003-7. 2007
  2. pmc Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    Cheng Ming Sun
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:1775-85. 2007
  3. pmc Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
    Ivaylo I Ivanov
    Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Cell Host Microbe 4:337-49. 2008
  4. pmc The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes
    Francesco Rubino
    IRCAD European Institute of Telesurgery, University Louis Pasteur, Strasbourg, France
    Ann Surg 244:741-9. 2006
  5. pmc Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 103:3920-5. 2006
  6. ncbi Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
    J Rodrigo Mora
    The Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 424:88-93. 2003
  7. ncbi Expression pattern of Wnt signaling components in the adult intestine
    Alex Gregorieff
    Netherlands Institute for Developmental Biology and Center for Biomedical Genetics, Hubrecht Laboratory, Utrecht
    Gastroenterology 129:626-38. 2005
  8. ncbi Wnt signalling induces maturation of Paneth cells in intestinal crypts
    Johan H van Es
    Hubrecht Institute, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Nat Cell Biol 7:381-6. 2005
  9. pmc Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity
    E J Kunkel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Exp Med 192:761-8. 2000
  10. doi Morphometrics of the avian small intestine compared with that of nonflying mammals: a phylogenetic approach
    Shana R Lavin
    Department of Wildlife Ecology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Physiol Biochem Zool 81:526-50. 2008

Detail Information

Publications341 found, 100 shown here

  1. ncbi Identification of stem cells in small intestine and colon by marker gene Lgr5
    Nick Barker
    Hubrecht Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Nature 449:1003-7. 2007
    ..that four to six crypt stem cells reside at the +4 position immediately above the Paneth cells in the small intestine; colon stem cells remain undefined...
  2. pmc Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    Cheng Ming Sun
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:1775-85. 2007
    ..Dendritic cells (DCs) purified from the lamina propria (Lp; LpDCs) of the small intestine were found to promote a high level of T reg cell conversion relative to lymphoid organ-derived DCs...
  3. pmc Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
    Ivaylo I Ivanov
    Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Cell Host Microbe 4:337-49. 2008
    ..We report that Th17 cell differentiation in the lamina propria (LP) of the small intestine requires specific commensal microbiota and is inhibited by treating mice with selective antibiotics...
  4. pmc The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes
    Francesco Rubino
    IRCAD European Institute of Telesurgery, University Louis Pasteur, Strasbourg, France
    Ann Surg 244:741-9. 2006
    ..We sought to distinguish between these two mechanisms...
  5. pmc Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 103:3920-5. 2006
    Obstruction of bile flow results in bacterial proliferation and mucosal injury in the small intestine that can lead to the translocation of bacteria across the epithelial barrier and systemic infection...
  6. ncbi Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
    J Rodrigo Mora
    The Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 424:88-93. 2003
    ..dendritic cells induced high levels of alpha4beta7, responsiveness to TECK and the ability to home to the small intestine. These findings establish that Peyer's patch dendritic cells imprint gut-homing specificity on T cells, and ..
  7. ncbi Expression pattern of Wnt signaling components in the adult intestine
    Alex Gregorieff
    Netherlands Institute for Developmental Biology and Center for Biomedical Genetics, Hubrecht Laboratory, Utrecht
    Gastroenterology 129:626-38. 2005
    ..To address this issue, we examined the expression pattern of all Wnts, Frizzleds (Fzs), low-density lipoprotein receptor-related proteins, Wnt antagonists, and T-cell factors in the murine small intestine and colon and adenomas.
  8. ncbi Wnt signalling induces maturation of Paneth cells in intestinal crypts
    Johan H van Es
    Hubrecht Institute, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Nat Cell Biol 7:381-6. 2005
    ..These observations imply that Wnt signals in the crypt can separately drive a stem-cell/progenitor gene programme and a Paneth-cell maturation programme. In intestinal cancer, both gene programmes are activated simultaneously...
  9. pmc Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity
    E J Kunkel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Exp Med 192:761-8. 2000
    ..a chemoattractant receptor expressed at high levels by essentially all CD4(+) and CD8(+) T lymphocytes in the small intestine. Only a small subset of lymphocytes in the colon are CCR9(+), and lymphocytes from other tissues including ..
  10. doi Morphometrics of the avian small intestine compared with that of nonflying mammals: a phylogenetic approach
    Shana R Lavin
    Department of Wildlife Ecology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Physiol Biochem Zool 81:526-50. 2008
    ..The small intestine is the primary site of absorption of most nutrients (e.g...
  11. pmc The human neonatal small intestine has the potential for arginine synthesis; developmental changes in the expression of arginine-synthesizing and -catabolizing enzymes
    Eleonore S Köhler
    Department of Anatomy and Embryology, Maastricht University, Maastricht, The Netherlands
    BMC Dev Biol 8:107. 2008
    ..Milk contains too little arginine for normal growth, but its precursors proline and glutamine are abundant; the small intestine of rodents and piglets produces arginine from proline during the suckling period; and parenterally fed ..
  12. doi Regionalization of pIgR expression in the mucosa of mouse small intestine
    Aldo A Reséndiz-Albor
    Sección de Estudios de Postgrado e Investigación, Laboratorio de Inmunidad de Mucosas, Escuela Superior de Medicina, Instituto Politecnico Nacional, Plan de San Luis y Diaz Miron, Mexico, D F, Mexico
    Immunol Lett 128:59-67. 2010
    ..differences in cell populations or immunological functions between the proximal and distal segments of the small intestine (SI)...
  13. ncbi Enterocyte proliferation and apoptosis in the caudal small intestine is influenced by the composition of colonizing commensal bacteria in the neonatal gnotobiotic pig
    B P Willing
    Department of Animal and Poultry Science, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan, Canada
    J Anim Sci 85:3256-66. 2007
    ..Induction of inflammatory responses and activation of apoptosis through death receptors appears to play a significant role in enterocyte turnover mediated by commensal bacteria...
  14. ncbi Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine
    Hiromasa Hamada
    Department of Microbiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Immunol 168:57-64. 2002
    ..with closely packed lymphocytes, can be found throughout the length of the antimesenteric wall of the mouse small intestine. They are composed of a large B cell area, including a germinal center, and epithelia overlying the clusters ..
  15. pmc Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism
    Bernat Crosas
    Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, E 08193 Bellaterra Barcelona, Spain
    Biochem J 373:973-9. 2003
    ....
  16. ncbi Structural basis for gluten intolerance in celiac sprue
    Lu Shan
    Department of Chemical Engineering, Stanford University, Stanford, CA 94305 5025, USA
    Science 297:2275-9. 2002
    Celiac Sprue, a widely prevalent autoimmune disease of the small intestine, is induced in genetically susceptible individuals by exposure to dietary gluten...
  17. doi Immunohistochemical analysis of neuron types in the mouse small intestine
    Zheng Dong Qu
    Department of Anatomy and Cell Biology and Centre for Neuroscience, University of Melbourne, Parkville, Victoria, 3010, Australia
    Cell Tissue Res 334:147-61. 2008
    The definition of the nerve cell types of the myenteric plexus of the mouse small intestine has become important, as more researchers turn to the use of mice with genetic mutations to analyze roles of specific genes and their products in ..
  18. pmc Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii
    O Liesenfeld
    Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, California 94301, USA
    J Exp Med 184:597-607. 1996
    ..gondii, whereas the same cytokine plays a critical role in the resistance of genetically resistant BALB/c mice...
  19. ncbi Cry1Ac protoxin from Bacillus thuringiensis sp. kurstaki HD73 binds to surface proteins in the mouse small intestine
    R I Vázquez-Padrón
    Center for Genetic Engineering and Biotechnology CIGB, Havana, 10600, Cuba
    Biochem Biophys Res Commun 271:54-8. 2000
    ..test we demonstrated that Cry1Ac protoxin (pCry1Ac) binds to the mucosal surface of the mouse small intestine. Ligand blot assay allowed us to detect, under denaturing conditions, six pCry1Ac-binding polypeptides ..
  20. ncbi A novel mouse gene family coding for cationic, cysteine-rich peptides. Regulation in small intestine and cells of myeloid origin
    A J Ouellette
    Cell Biology Unit, Shriners Burns Institute, Boston, Massachusetts 02114
    J Biol Chem 265:9831-7. 1990
    ..Cryptdin, CRS1C, and CRS4C mRNAs are transcribed from separate genes, occur at equivalent abundance in small intestine, and appear in the small bowel in concert during the 2nd and 3rd weeks postpartum...
  21. ncbi Interstitial cells of Cajal could regenerate and restore their normal distribution after disrupted by intestinal transection and anastomosis in the adult guinea pigs
    Feng Mei
    Department of Histology and Embryology, Third Military Medical University, Chongqing, 400038, People s Republic of China
    Virchows Arch 449:348-57. 2006
    ..Our results indicated that ICCs could regenerate and restore their normal distribution after intestinal surgery and SMCs might be involved in the regenerated events of ICCs in the adult guinea pig GI tract...
  22. ncbi Morphology and ultrastructure of small intestine mucosa in gilts with zearalenone mycotoxicosis
    K Obremski
    Division of Veterinary Prophylaxis and Feed Hygiene, Department of Veterinary Health Protection, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Poland
    Pol J Vet Sci 8:301-7. 2005
    ..The morphology and ultrastructure of the small intestine mucosa were assessed after the course of the experimental zearalenone mycotoxicosis...
  23. pmc CCR9 is a homing receptor for plasmacytoid dendritic cells to the small intestine
    Meike Wendland
    Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 104:6347-52. 2007
    b>Small intestine plasmacytoid dendritic cells (pDC) are poorly characterized...
  24. pmc PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression
    Heleen M de Vogel-van den Bosch
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, PO Box 8129, NL 6700EV, Wageningen, The Netherlands
    BMC Genomics 9:231. 2008
    The selective absorption of nutrients and other food constituents in the small intestine is mediated by a group of transport proteins and metabolic enzymes, often collectively called 'intestinal barrier proteins'...
  25. ncbi Microbial communities in the human small intestine: coupling diversity to metagenomics
    Carien C G M Booijink
    Wageningen Centre for Food Sciences, and Laboratory of Microbiology, Hesselink van Suchtelenweg 4, Wageningen, The Netherlands
    Future Microbiol 2:285-95. 2007
    ..The host-derived physiological processes and the residing microorganisms, especially in the small intestine, contribute to this nutrient supply...
  26. ncbi Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis
    John M Mariadason
    Montefiore Medical Cente, Albert Einstein Cancer Center, Bronx, New Yorrk 10467, USA
    Gastroenterology 128:1081-8. 2005
    To define the genetic reprogramming that drives intestinal epithelial cell maturation along the crypt-villus axis, enterocytes were sequentially isolated from the villus tip to the crypts of mouse small intestine.
  27. ncbi Activation of intrinsic afferent pathways in submucosal ganglia of the guinea pig small intestine
    H Pan
    Department of Anatomy, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 20:3295-309. 2000
    ..Slow EPSPs are necessary for excitation to spread within the submucosal plexus. Because some second-order neurons contain also CGRP, primary afferent neurons may be multifunctional and also serve as interneurons...
  28. pmc Symbiotic bacteria direct expression of an intestinal bactericidal lectin
    Heather L Cash
    Center for Immunology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 313:1126-30. 2006
    ..We propose that these proteins represent an evolutionarily primitive form of lectin-mediated innate immunity, and that they reveal intestinal strategies for maintaining symbiotic host-microbial relationships...
  29. ncbi The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system
    K A Papadakis
    Department of Medicine, Division of Gastroenterology and Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, University of California, Los Angeles School of Medicine, Los Angeles, CA 90048, USA
    J Immunol 165:5069-76. 2000
    ..which signals through the chemokine receptor CCR9, is constitutively expressed in the thymus and small intestine but not colon, and chemoattracts a small fraction of PBLs that coexpress the integrin alpha(4)beta(7)...
  30. pmc Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting
    Heleen M van den Bosch
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen, University, Wageningen, The Netherlands
    BMC Genomics 8:267. 2007
    ..We therefore investigated the effects of fasting on expression of these genes using Affymetrix GeneChip MOE430A arrays and quantitative RT-PCR...
  31. pmc Fasting induces a biphasic adaptive metabolic response in murine small intestine
    Milka Sokolovic
    AMC Liver Centre, Academic Medical Centre, Amsterdam, The Netherlands
    BMC Genomics 8:361. 2007
    ..Gene-expression profiling, pathway analysis, and immunohistochemistry were therefore carried out on mouse small intestine after 0, 12, 24, and 72 hours of fasting.
  32. ncbi Retinal dehydrogenase gene expression in stomach and small intestine of rats during postnatal development and in vitamin A deficiency
    P V Bhat
    CHUM Research Centre Hôtel Dieu Campus, Department of Medicine, University of Montreal, Que, Canada
    FEBS Lett 426:260-2. 1998
    ..We have recently shown the expression of RALDH transcript in the stomach and small intestine by reverse transcription polymerase chain reaction [Bhat, P.V., Labrecque J., Dumas, F., Lacroix, A...
  33. doi Measurement of caffeic and ferulic acid equivalents in plasma after coffee consumption: small intestine and colon are key sites for coffee metabolism
    Mathieu Renouf
    Nestle Research Center, Nestec Limited, Vers chez les Blanc, Lausanne, Switzerland
    Mol Nutr Food Res 54:760-6. 2010
    Previous studies on coffee examined absorption of phenolic acids (PA) in the small intestine, but not the contribution of the colon to absorption...
  34. pmc Shigella enterotoxin 1: an enterotoxin of Shigella flexneri 2a active in rabbit small intestine in vivo and in vitro
    A Fasano
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore 21201, USA
    J Clin Invest 95:2853-61. 1995
    ..ShET1, which is composed of two distinct subunits and is elaborated in vivo, where it elicits an immune response, may be important in the pathogenesis of diarrheal illness due to S. flexneri 2a...
  35. ncbi Heat-killed bacteria induce genome instability in mouse small intestine, liver and spleen tissues
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada
    Cell Cycle 8:1935-9. 2009
    ..Control animals received tap water. One week after exposure, molecular changes were analyzed in the small intestine, an organ that is in immediate contact with contaminated water...
  36. ncbi Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea
    Jihyeung Ju
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Cancer Res 65:10623-31. 2005
    ....
  37. pmc Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation
    K R Greenow
    Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    Oncogene 28:1443-53. 2009
    ..mouse model in which Chkl can be inducibly deleted from somatic epithelial cells in the adult mouse small intestine and liver. Loss of Chk1 in the liver is tolerated with no apparent phenotype...
  38. ncbi Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation
    A J Merritt
    Cancer Research Campaign Department of Epithelial Biology, Christie Hospital Trust, School of Biological Sciences, The University of Manchester, UK
    Oncogene 14:2759-66. 1997
    ..In contrast, irradiation with 1 Gy failed to induce a p53-independent apoptosis in vivo, suggesting that the p53 'sensor' of damage was more sensitive than that engaging the p53-independent mechanism of cell death...
  39. ncbi Characterization of a putative receptor for intestinal trefoil factor in rat small intestine: identification by in situ binding and ligand blotting
    X D Tan
    Department of Pathology, Children s Memorial Hospital, Northwestern University, Chicago, Illinois 60614, USA
    Biochem Biophys Res Commun 237:673-7. 1997
    ..By using bTag-ITF probe, we identified ITF binding cells in the crypts of the small intestine and mucous cells of the region of gastric glands...
  40. doi Segmental dependent transport of low permeability compounds along the small intestine due to P-glycoprotein: the role of efflux transport in the oral absorption of BCS class III drugs
    Arik Dahan
    College of Pharmacy, The University of Michigan, Ann Arbor, Michigan 48109 1065, USA
    Mol Pharm 6:19-28. 2009
    ..and famotidine, was determined by the single-pass intestinal perfusion model in different regions of the rat small intestine, in the presence or absence of the P-gp inhibitor verapamil...
  41. ncbi Characterization of myenteric sensory neurons in the mouse small intestine
    Yukang Mao
    Brain Brody Institute, McMaster University, Hamilton, Ontario, Canada
    J Neurophysiol 96:998-1010. 2006
    ..The characterization of mouse myenteric sensory neurons opens the way for the study of their roles in normal and pathological physiology...
  42. doi Very long-term self-renewal of small intestine, colon, and hair follicles from cycling Lgr5+ve stem cells
    N Barker
    Hubrecht Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Cold Spring Harb Symp Quant Biol 73:351-6. 2008
    ..At the bottoms of crypts in small intestine and colon as well as in hair follicles, Lgr5 marks cycling cells with stem cell properties (Barker et al...
  43. pmc Small intestinal bacterial overgrowth in patients with irritable bowel syndrome
    Iris Posserud
    Department of Internal Medicine, Sahlgrenska University Hospital, 41345 Goteborg, Sweden
    Gut 56:802-8. 2007
    ..Small intestinal bacterial overgrowth (SIBO) has been proposed to be common in irritable bowel syndrome (IBS), with altered small-bowel motility as a possible predisposing factor...
  44. ncbi Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines
    Sandro Drago
    Mucosal Biology Research Center, Center for Celiac Research and Division of Pediatric Gastroenterology and Nutrition, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Scand J Gastroenterol 41:408-19. 2006
    ..We investigated whether gliadin has any immediate effect on zonulin release and signaling...
  45. pmc The epidemiology and pathogenesis of neoplasia in the small intestine
    David Schottenfeld
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA
    Ann Epidemiol 19:58-69. 2009
    The mucosa of the small intestine encompasses about 90% of the luminal surface area of the digestive system, but only 2% of the total annual gastrointestinal cancer incidence in the United States.
  46. doi A temporal shift in regulatory networks and pathways in the bovine small intestine during Cooperia oncophora infection
    Robert W Li
    Bovine Functional Genomics Laboratory, U S Department of Agriculture Agricultural Research Service, BARC East, Beltsville, MD 20705, USA
    Int J Parasitol 39:813-24. 2009
    ..Gene expression profiles of the small intestine were compared using a high-density bovine 60 mer oligo microarray...
  47. ncbi Allergy controls the population density of Necator americanus in the small intestine
    John Croese
    The Department of Gastroenterology, The Townsville Hospital, Townsville, Australia
    Gastroenterology 131:402-9. 2006
    ..As part of a study evaluating a potential role for hookworms in the modulation of human autoimmunity, we examined parasite migration and intestinal colonization...
  48. doi Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine
    Andreas Artmann
    Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Biochim Biophys Acta 1781:200-12. 2008
    ....
  49. ncbi Ureteral reconstruction: small intestine submucosa for the management of strictures and defects of the upper third of the ureter
    E N Liatsikos
    Department of Urology, Albert Einstein College of Medicine, Long Island Jewish Medical Center, New Hyde Park, New York, USA
    J Urol 165:1719-23. 2001
    PURPOSE: We evaluated the effectiveness of small intestine submucosa in ureteral reconstruction. MATERIALS AND METHODS: We report an experimental study in 6 female pigs weighing between 50 and 60 pounds...
  50. ncbi Myc deletion rescues Apc deficiency in the small intestine
    Owen J Sansom
    The Beatson Institute, Garscube Estate, Glasgow G61 1BD, UK
    Nature 446:676-9. 2007
    ..Myc has in the intestine after Apc loss, we have simultaneously deleted both Apc and Myc in the adult murine small intestine. Here we show that loss of Myc rescued the phenotypes of perturbed differentiation, migration, proliferation ..
  51. pmc Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine
    Tjalling Bosse
    GI Cell Biology, EN 720, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell Biol 26:9060-70. 2006
    ..the regional expression of Gata4 is critical for the maintenance of jejunal-ileal homeostasis in the adult small intestine in vivo, we established an inducible, intestine-specific model that results in the synthesis of a ..
  52. ncbi Phenotypic characterization of taste cells of the mouse small intestine
    Kate Sutherland
    Discipline of Physiology, School of Molecular and Biomedical Sciences, University of Adelaide, Australia
    Am J Physiol Gastrointest Liver Physiol 292:G1420-8. 2007
    Nutrient-evoked gastrointestinal reflexes are likely initiated by specialized epithelial cells located in the small intestine that detect luminal stimuli and release mediators that activate vagal endings...
  53. ncbi Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell
    D S Krause
    Department of Laboratory Medicine and, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 105:369-77. 2001
    ..This finding may contribute to clinical treatment of genetic disease or tissue repair...
  54. pmc Vibrio cholerae RND family efflux systems are required for antimicrobial resistance, optimal virulence factor production, and colonization of the infant mouse small intestine
    Xiaowen R Bina
    Department of Molecular Sciences, University of Tennessee Health Science Center, 858 Madison Avenue, Memphis, TN 38163, USA
    Infect Immun 76:3595-605. 2008
    ..Our findings show that the V. cholerae RND efflux systems are required for antimicrobial resistance, optimal virulence factor production, and colonization of the infant mouse...
  55. ncbi Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion
    Kevin G E Scott
    Department of Biological Sciences, University of Calgary, Alberta, Canada
    Gastroenterology 123:1179-90. 2002
    ..This study was conducted to determine whether Giardia spp. alters intestinal permeability in vivo, to assess whether these abnormalities are dependent on T cells, and to assess the role of MLCK in altered epithelial barrier function...
  56. pmc Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation
    Noriko Shikama
    Institute for Molecular Biology, University of Zurich, 8057 Zurich, Switzerland
    EMBO J 22:5175-85. 2003
    ..Formation of the cardiovascular system, the lung and the small intestine are strongly impaired in p300 AT and to a much lesser extent in Cbp AT mutant embryos, a difference that is ..
  57. doi Normalizing genes for real-time polymerase chain reaction in epithelial and nonepithelial cells of mouse small intestine
    Fengchao Wang
    Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, College of Preventive Medicine, Third Military Medical University, 30 Gaotanyan Road, Shapingba District, Chongqing 400038, China
    Anal Biochem 399:211-7. 2010
    ..and stromal cells are a common tool for investigating the mechanisms by which the homeostasis of the small intestine is regulated under normal and pathological conditions...
  58. ncbi Improved capsule endoscopy after bowel preparation
    Ning Dai
    Division of Gastroenterology, Sir Run Run Shaw Hospital, Clinical Research Institute, Zhejiang University, China
    Gastrointest Endosc 61:28-31. 2005
    ..This study examined the effect of bowel preparation on the volume of intestinal content and on small-bowel transit...
  59. ncbi Expression of multidrug resistance-associated protein 2 in small intestine from pregnant and postpartum rats
    A D Mottino
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    Am J Physiol Gastrointest Liver Physiol 280:G1261-73. 2001
    We analyzed the expression of multidrug resistance-associated protein 2 (mrp2) in the small intestine of control female rats and in rats during late pregnancy (19-20 days of pregnancy) and lactation (2-4, 10-14, and 21 days after ..
  60. ncbi Fatty acid regulation of fatty acid-binding protein expression in the small intestine
    H Poirier
    Laboratoire de Physiologie de la Nutrition, Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l Alimentation, Universite de Bourgogne, Dijon, France
    Am J Physiol 273:G289-95. 1997
    ..intestinal and liver fatty acid-binding proteins (I-FABP and L-FABP, respectively) were investigated in the small intestine of mice. A daily force-feeding for 7 days with 0...
  61. pmc Successful small intestine colonization of adult mice by Vibrio cholerae requires ketamine anesthesia and accessory toxins
    Verena Olivier
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 4:e7352. 2009
    Vibrio cholerae colonizes the small intestine of adult C57BL/6 mice. In this study, the physical and genetic parameters that facilitate this colonization were investigated...
  62. pmc Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium
    Eric J Formeister
    Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, NC 27599, USA
    Am J Physiol Gastrointest Liver Physiol 296:G1108-18. 2009
    ..SOX9 is expressed in the small intestine epithelial stem cell zone...
  63. ncbi The expression of PPAR-associated genes is modulated through postnatal development of PPAR subtypes in the small intestine
    K Mochizuki
    Department of Nutrition, School of Food and Nutritional Sciences, University of Shizuoka, Japan
    Biochim Biophys Acta 1531:68-76. 2001
    ..such as acyl-CoA oxidase, L-FABP, and I-FABP, were also increased during the postnatal development of the small intestine. Electrophoretic mobility shift assay revealed that both the PPARalpha-9-cis-retinoic acid receptor alpha (..
  64. ncbi Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen
    O Pabst
    Department of Cell and Molecular Biology, University of Braunschweig, Spielmannstrasse 7, Germany
    Development 126:2215-25. 1999
    ..Villus formation in the small intestine appears considerably delayed in Nkx2-3(-)/- foetuses due to reduced proliferation of the epithelium, while ..
  65. ncbi Excretion of bisphenol A-glucuronide into the small intestine and deconjugation in the cecum of the rat
    Hirokazu Sakamoto
    Department of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, 582 1 Bunkyodai Midorimachi, Ebetsu, Hokkaido 069 8501, Japan
    Biochim Biophys Acta 1573:171-6. 2002
    ..In the present study, we found that most of the bisphenol A-glucuronide (BPA-GA) excreted into the small intestine was deconjugated in the contents of the cecum...
  66. ncbi Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii
    Markus M Heimesaat
    Institut für Mikrobiologie und Hygiene, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin and Campus Mitte, Hindenburgdamm 27, D 12203 Berlin, Germany
    J Immunol 177:8785-95. 2006
    ..Thus, pathogen-induced acute ileitis may prove useful to study bacteria-host interactions in small intestinal inflammation and to test novel therapies based on modulation of gut flora...
  67. ncbi Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2
    Kihang Choi
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    Chem Biol 12:469-75. 2005
    ..Together, these findings demonstrate the promise of dihydroisoxazole compounds as probes for the biology of TG2 and its role in human disease...
  68. doi Downregulation of Th17 cells in the small intestine by disruption of gut flora in the absence of retinoic acid
    Hye Ran Cha
    Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Korea
    J Immunol 184:6799-806. 2010
    ..We found that a VAD diet resulted in significant inhibition of Th17 cell differentiation in the small intestine lamina propria by as early as age 5 wk...
  69. ncbi Transepithelial pathogen uptake into the small intestinal lamina propria
    Alexandra Vallon-Eberhard
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Immunol 176:2465-9. 2006
    ..Interestingly, transepithelial dendrites seem altogether absent from the small intestine of BALB/c mice suggesting that the function of lamina propria DC extensions resides in their potential ..
  70. pmc Laminin alpha 5 influences the architecture of the mouse small intestine mucosa
    Zhen X Mahoney
    Department of Internal Medicine Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Sci 121:2493-502. 2008
    The mammalian intestine displays two distinct patterns of mucosal organization. The small intestine contains mucosal epithelial invaginations (the crypts of Lieberkühn) that are continuous with evaginations (villi) into the lumen...
  71. pmc Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury
    Matthew Siegel
    Department of Chemical Engineering, Stanford University, Stanford, California, United States of America
    PLoS ONE 3:e1861. 2008
    ..Our findings provide a new basis for understanding the role of TG2 in physiology and disease...
  72. ncbi MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine
    Chi Liang Eric Yen
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 1900, USA
    J Biol Chem 278:18532-7. 2003
    ..In humans, the MGAT2 gene is highly expressed in the small intestine, liver, stomach, kidney, colon, and white adipose tissue; in mice, it is expressed predominantly in the small ..
  73. ncbi Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin
    M L Hermiston
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 270:1203-7. 1995
    ..This model provides insights about cadherin function in an adult organ and the factors underlying inflammatory bowel disease and intestinal neoplasia...
  74. pmc All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
    Micah J Benson
    Department of Microbiology and Immunology, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    J Exp Med 204:1765-74. 2007
    ..alpha 4 beta 7(+) CC chemokine receptor 9(+)) and the capacity to home to the lamina propria of the small intestine. Under conditions that favor the differentiation of A-Tregs (transforming growth factor-beta1 and interleukin ..
  75. ncbi Cellular inheritance of a Cre-activated reporter gene to determine Paneth cell longevity in the murine small intestine
    Heather Ireland
    Cancer Research UK Department of Oncology, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge, United Kingdom
    Dev Dyn 233:1332-6. 2005
    ....
  76. pmc Amyloid-beta colocalizes with apolipoprotein B in absorptive cells of the small intestine
    Susan Galloway
    The Australian Technology Network Centre for Metabolic Fitness, School of Public Health, Curtin Health Innovation Research Institute, Curtin University of Technology, Perth, Western Australia, Australia
    Lipids Health Dis 8:46. 2009
    ..To consider this hypothesis further, this study utilized an in vivo immunological approach to explore in lipogenic tissue whether amyloid-beta colocalizes with nascent triglyceride-rich lipoproteins...
  77. doi Dietary phloridzin reduces blood glucose levels and reverses Sglt1 expression in the small intestine in streptozotocin-induced diabetic mice
    Saeko Masumoto
    National Food Research Institute, Tsukuba, Ibaraki, Japan
    J Agric Food Chem 57:4651-6. 2009
    ..the sodium/glucose cotransporter gene Sglt1 and the drug-metabolizing enzyme genes Cyp2b10 and Ephx1 in the small intestine of mice fed a 0.5% phloridzin diet...
  78. ncbi Hemodynamic and proinflammatory actions of endothelin-1 in guinea pig small intestine submucosal microcirculation
    C E King-VanVlack
    School of Rehabilitation Therapy, Department of Physiology, and Department of Surgery, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Am J Physiol Gastrointest Liver Physiol 284:G940-8. 2003
    ..ET-1) in proximal (1st/2nd order) and terminal (3rd/4th order) arterioles and venules were examined in small intestine submucosa of anesthetized guinea pigs...
  79. doi A model of the isolated perfused rat small intestine
    Ingmar Lautenschläger
    Department of Anesthesiology and Intensive Care Medicine, University Medical Center Schleswig Holstein, Campus Kiel, Schwanenweg 21, Kiel, Germany
    Am J Physiol Gastrointest Liver Physiol 298:G304-13. 2010
    ..This new model provides detailed insights into the physiology of the small intestine and will allow to study fundamental processes such as fluid homeostasis, barrier functions, transport ..
  80. ncbi Small intestine bacterial overgrowth is frequent in cystic fibrosis: combined hydrogen and methane measurements are required for its detection
    Aleksandra Lisowska
    Department of Pediatric Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland
    Acta Biochim Pol 56:631-4. 2009
    Hydrogen breath test (BT) is commonly used as a diagnostic tool for the detection of small intestine bacterial overgrowth (SIBO)...
  81. pmc Increasing prevalence and high incidence of celiac disease in elderly people: a population-based study
    Anitta Vilppula
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    BMC Gastroenterol 9:49. 2009
    ....
  82. doi Ion transport in the small intestine
    Jayashree Venkatasubramanian
    Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Curr Opin Gastroenterol 26:123-8. 2010
    ....
  83. ncbi A simple new method to calculate small intestine absorptive surface in the rat
    K Kisielinski
    Department of Surgery, University Hospital Aachen, Germany, Pauwelsstrasse 30, 52074 Aachen, Germany
    Clin Exp Med 2:131-5. 2002
    ..In the study of functional and morphological adaptations of the small intestine, it is helpful to estimate the mucosal surface area...
  84. ncbi Histological estimation of the small intestine wall after administration of feed containing deoxynivalenol, T-2 toxin and zearalenone in the pig
    K Obremski
    Division of Veterinary Prophylaxis and Feed Hygiene, Department of Veterinary Health Protection, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10 718 Olsztyn, Poland
    Pol J Vet Sci 11:339-45. 2008
    ..The aim of this study was to perform histological estimation of the porcine small intestine after short term intoxication with low doses of deoxynivalenol (DON), T-2 toxin (T-2) and zearalenone (ZEA) ..
  85. ncbi The small intestine proteome is changed in preterm pigs developing necrotizing enterocolitis in response to formula feeding
    Pingping Jiang
    Division of Agricultural, Food and Nutritional Science, School of Biological Sciences, The University of Hong Kong, Hong Kong S A R, P R China
    J Nutr 138:1895-901. 2008
    ..The data provided novel mechanistic insights into the pathogenesis of NEC and the insults of a formulated diet to the premature gut...
  86. ncbi beta-amyloid or its precursor protein is found in epithelial cells of the small intestine and is stimulated by high-fat feeding
    Susan Galloway
    School of Biomedical Science, Curtin University of Technology, Perth, Western Australia 6102, Australia
    J Nutr Biochem 18:279-84. 2007
    ..approach to determine if Abeta or its precursor protein is expressed in epithelial cells of the small intestine -- the site of chylomicron biogenesis...
  87. ncbi Association between glutamine extraction and release of citrulline and glycine by the human small intestine
    Tetsuji Fujita
    Department of Surgery, Jikei University School of Medicine, Tokyo, Japan
    Life Sci 80:1846-50. 2007
    ..Mean extraction rate of glutamine by the small intestine was 28.45%, approximately 3 times higher than 9.41% in the distal colon...
  88. ncbi Small intestine submucosa in urethral stricture repair in a consecutive series
    Stefan Hauser
    Klinik und Poliklinik fur Urologie, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Urology 68:263-6. 2006
    To define the feasibility of acellular porcine small intestine submucosa (SIS) as a xenograft implant. SIS is commercially available and approved for use in humans.
  89. ncbi NOD2-expressing bone marrow-derived cells appear to regulate epithelial innate immunity of the transplanted human small intestine
    T Fishbein
    Transplant Institute, Georgetown University Hospital, Washington, DC, USA
    Gut 57:323-30. 2008
    ..An investigation was carried out to determine whether epithelial immune function and graft survival were influenced by NOD2 mutations in an intestinal transplant population...
  90. ncbi Intrauterine growth restriction affects the proteomes of the small intestine, liver, and skeletal muscle in newborn pigs
    Junjun Wang
    State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, China 100094
    J Nutr 138:60-6. 2008
    ..test the hypothesis that IUGR affects expression of key proteins that regulate growth and development of the small intestine, liver, and muscle, the major organs involved in the digestion, absorption, and metabolism of dietary ..
  91. ncbi Circumferential mural bands in the small intestine causing simple obstructive colic: a case series
    J F Perez Olmos
    Troytown Equine Hospital, Kildare, Ireland
    Equine Vet J 38:354-9. 2006
    Circumferential mural band (CMB) in the small intestine is an emerging condition in Ireland. The clinical presentation is a simple obstruction of the small intestine of unknown aetiology.
  92. pmc Synergistic effects of high fat feeding and apolipoprotein E deletion on enterocytic amyloid-beta abundance
    Susan Galloway
    School of Public Health and Australian Technology Network ATN, Centre for Metabolic Fitness, Curtin University of Technology, Perth, Western Australia
    Lipids Health Dis 7:15. 2008
    ..amyloid plaques of subjects with Alzheimer's disease is expressed in the absorptive epithelial cells of the small intestine. Ingestion of saturated fat significantly enhances enterocytic Abeta abundance whereas fasting abolishes ..
  93. doi Suppression of inflammatory cytokine production and oxidative stress by CO-releasing molecules-liberated CO in the small intestine of thermally-injured mice
    Dong ming Liu
    Department of Burns and Plastic Surgery, Affiliated Hospital, Jiangsu University, Zhenjiang 212001, China
    Acta Pharmacol Sin 29:838-46. 2008
    To determine whether carbon monoxide (CO)-releasing molecules-liberated CO suppress inflammatory cytokine production and oxidative stress in the small intestine of burnt mice.
  94. ncbi Obstruction of equine small intestine associated with focal idiopathic eosinophilic enteritis: an emerging disease?
    Debra C Archer
    Department of Veterinary Clinical Science and Animal Husbandry, University of Liverpool, Leahurst, Neston, Wirral CH64 7TE, UK
    Vet J 171:504-12. 2006
    ..Diagnosis of IFEE was made at laparotomy and confirmed by histological examination of resected abnormal small intestine. In all 12 horses colic was associated with jejunal obstruction involving visibly striking and palpably ..
  95. pmc The human intestinal cytochrome P450 "pie"
    Mary F Paine
    General Clinical Research Center, Room 3005 Bldg APCF, CB 7600, UNC Hospitals, Chapel Hill, NC 27599 7600, USA
    Drug Metab Dispos 34:880-6. 2006
    ..The P450 profile in the human small intestine has not been fully characterized...
  96. doi Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine
    Jeffrey Gagnon
    The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada K1Y 4E9
    Regul Pept 152:54-60. 2009
    ..Over its three successive regions, the duodenum, the jejunum and the ileum, the small intestine (SI) expresses over 40 peptide hormones necessary for normal intestinal physiology...
  97. pmc Coeliac disease: an update for pathologists
    B C Dickson
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    J Clin Pathol 59:1008-16. 2006
    ....
  98. ncbi Adverse effects of porcine small intestine submucosa implants in experimental ventral hernia repair
    A H Petter-Puchner
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Research Center for Traumatology of AUVA, Donaueschingenstrasse 13, A 1200, Vienna, Austria
    Surg Endosc 20:942-6. 2006
    Biomeshes made of porcine small intestine submucosa (SIS) have recently been suggested for repair of ventral hernia...
  99. ncbi bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine
    S Kamada
    Department of Medical Genetics, Biomedical Research Center, Osaka University Medical School, Yamadaoka, Japan
    Cancer Res 55:354-9. 1995
    ..Our bcl-2-/- mice also revealed novel defects in the small intestine, characterized by retarded development, accelerated exfoliation of epithelial cells, and very few mitotic ..
  100. ncbi In vitro-in vivo correlations for lipophilic, poorly water-soluble drugs
    J B Dressman
    Institute of Pharmaceutical Technology, J W Goethe University, Frankfurt am Main, Germany
    Eur J Pharm Sci 11:S73-80. 2000
    ..These are SGF, milk, FASSIF and FeSSIF, which model fasted and fed state conditions in the stomach and small intestine respectively...
  101. ncbi The role of mast cells in mucosal permeability changes during ischemia-reperfusion injury of the small intestine
    A Szabo
    Institute of Experimental Surgery, Szent Györgyi Albert Medical University, Szeged, Hungary
    Shock 8:284-91. 1997
    ..We conclude that intestinal mast cells and mast cell-induced reactions contribute to the mucosal permeability alterations during reperfusion, but play only a minor role in ischemia-reperfusion-induced structural injury...

Research Grants75

  1. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..the effector function of memory B cells in peripheral blood, broncho-alveolar lavage (BAL), bone marrow (BM), small intestine and lymph node tissues from SIV infected macaques...
  2. DNA Damage and Response in the Bladder Microenvironment.
    Bradley P Dixon; Fiscal Year: 2013
    ..In the in vitro portion of these experiments, gastric, colon, small intestine, and bladder epithelial cell lines from the H-2Kb- tsA58 mouse will be gradually adapted to hyperosmolal ..
  3. Vitamin D Hormone Signaling in Bone Mineral Homeostasis
    Mark R Haussler; Fiscal Year: 2010
    ..Aim 2 will probe the role of 1,25(OH)2D3-VDR to stimulate calcium and phosphate translocation in small intestine and kidney through the enhanced expression of epithelial calcium transporter 1 (TRPV6) and sodium-phosphate ..
  4. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2012
    ..Aim 1 will involve identification of cellular mediators of CBLB502's effect on protection and healing of small intestine in irradiated mice with particular attention on the role of bone marrow-derived cells...
  5. Regulation of the Vibrio cholerae intestinal exit plan
    ANISIA J SILVA BENITEZ; Fiscal Year: 2010
    ..V. cholerae colonizes the human small intestine, secretes cholera toxin to cause diarrhea and detaches late in infection to return to the aquatic environment...
  6. Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondria
    PETER J contact HAVEL; Fiscal Year: 2010
    ..major anatomic alterations performed in Roux-en-Y gastric bypass (RYGB), namely IT surgery moves the distal small intestine proximally, resulting in increased contact of less completely digested nutrients with the mucosa of the ..
  7. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank A Anania; Fiscal Year: 2010
    ..Glucagon-like peptide (GLP-1) is a naturally occurring gut peptide secreted by the L cells of the small intestine. It is cleaved by dipeptidyl peptidase IV (DPPIV) and thus it biological half-life is short...
  8. Immune Development: Role of Milk Cell Transfer and Recipient Gender
    Ameae M Walker; Fiscal Year: 2013
    ..Eighty percent of the GFP+ cells observed crossing the small intestine of the pup at weeks 1 and 2 could be positively identified as CD8+ or CD4+ T cells...
  9. Regulation of Triglyceride Metabolism by the transcription factor CREB-H
    Ann Hwee Lee; Fiscal Year: 2013
    ..reticulum (ER)-bound transcription factor that is highly and selectively expressed only in the liver and the small intestine. CREB-H activation requires a sequential cleavage of its precursor protein by Golgi proteases that liberate ..
  10. Dietary Risk for Colon Cancer in the Mouse
    Leonard H Augenlicht; Fiscal Year: 2013
    ..In this aim we characterize the effects of the diets on inflammation and cytokine production of the colon and small intestine. Moreover, based on our recent reports dissecting the role of IL12 in mediating an important regulatory cross-..
  11. NPC1L1 and Metabolic Diseases
    Liqing Yu; Fiscal Year: 2013
    ..In mice, NPC1L1 is highly expressed in small intestine and only low levels of NPC1L1 mRNA can be detected in non-intestinal tissues...
  12. High affinity capturing agents for strychnine
    Kit S Lam; Fiscal Year: 2011
    ..At acidic pH (stomach), strychnine is ionized and rapidly and completely absorbed in the small intestine. In strychnine poisoning, the tissues with the highest strychnine concentrations are the blood, liver and ..
  13. Investigation on Oligosaccharides as Antimicrobial and Prebiotics
    Peng George Wang; Fiscal Year: 2013
    ..Oligosaccharides are not hydrolyzed in the upper small intestine and reach the large intestine intact, where they serve as substrates for bacterial metabolism...
  14. Celiac Disease: From Genetic Risk to Disease Development
    Susan L Neuhausen; Fiscal Year: 2009
    ..The term gluten-sensitive enteropathy refers to the histologic abnormality of the small intestine. It is now recognized to be a common disease, with reports that the disease frequency is 1:150 in the US, ..
  15. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin L Shneider; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: SBT, a protein found in the last portion of the small intestine, plays an important role in liver and intestinal function...
  16. Functions of the Human OST-alpha and OST-beta Proteins
    Patricia M Hinkle; Fiscal Year: 2013
    ..is an unusual heteromeric transporter that is expressed in nearly all tissues, but is most abundant in the small intestine, kidney, liver, testis, adrenal gland, as well as other steroidogenic tissues...
  17. Transcriptional regulation of enteroendocrine cell differentiation by NeuroD
    Andrew B Leiter; Fiscal Year: 2013
    ..expression profiling by high throughput sequencing (RNAseq) of RNA from NeuroD+ cells isolated from mouse small intestine by a new method developed by the principal investigator...
  18. Modeling oxidative stress and DNA damage using GI organotypic culture systems
    John P Lynch; Fiscal Year: 2013
    ..host disease (GVHD), acute rejection after small intestine transplantation, and IBD conditions like Ulcerative colitis (UC), are fairly common human diseases...
  19. Regulation of Organized Intestinal Lymphoid Tissues by TRANCE/RANKL
    Ifor R Williams; Fiscal Year: 2012
    ..On average, the small intestine of RANKL null mice has 74-fold fewer M cells detected by staining with the UEA-1 lectin than wild type ..
  20. PLCgamma regulates HNE3 activity through direct binding and dynamic complexes
    NICHOLAS CONSTANTINE ZACHOS; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: In the small intestine and colon, regulation of NHE3 activity accounts for most of the recognized changes in sodium absorption which ..
  21. An Innovative Endoscopic Instrument with Full-Field Viewing and Intelligent Imagi
    STEVEN YI; Fiscal Year: 2010
    ..in the United States alone for the examinations of digestive tract including the esophagus, stomach, small intestine, colon, and rectum. The associated national cost is over $60 billion per year...
  22. FUNCTION OF THE ENTERIC NERVOUS SYSTEM
    JACKIE WOOD; Fiscal Year: 2013
    ..the enteric nervous system (ENS), spinal sensory afferent innervation and enteric mast cells with guinea pig small intestine as the experimental model...
  23. Characterization of Diet1, a hypercholesterolemia resistance gene
    Karen Reue; Fiscal Year: 2013
    ..protein characterized by repeating MAM and LDL receptor type A domains, and is expressed predominantly in the small intestine. The Diet1 protein sequence is highly conserved between mouse and humans...
  24. Role of STAT3 in the pathogenesis of Inflammatory Bowel Disease
    Prema Robinson; Fiscal Year: 2013
    ..provided by applicant): Inflammatory bowel disease (IBD) is an idiopathic disease of the colon and small intestine. The major types of IBD are Crohn's disease (CD) and ulcerative colitis (UC). An estimated 1...
  25. Investigation of the liver progenitor cell niche using CK19 lineage tracing
    EUGENE SCOTT SWENSON; Fiscal Year: 2011
    ..provided by applicant): Adult stem cell niches have been identified in rapidly dividing tissues, such as the small intestine, skin and esophagus...
  26. Physiology and regulation of T2R bitter taste receptors in enteroendocrine cells
    Timothy F Osborne; Fiscal Year: 2013
    ..bitter T2 receptors are also expressed in areas outside of the oral cavity including the lung, pancreas, and small intestine. Their function in the tongue is obviously to allow taste discrimination between differen potential food ..
  27. Modulation of TLR4 and TLR9 Signaling in NEC
    David J Hackam; Fiscal Year: 2013
    ..the susceptibility of the premature infant to NEC based on increased TLR4-induced mucosal ER stress, and through the evaluation of novel anti-NEC therapies based upon the attenuation of ER stress within the premature small intestine.
  28. MODULATION OF INTESTINAL HOMEOSTASIS AND CANCER
    Leonard H Augenlicht; Fiscal Year: 2013
    ..tremendous expansion of the goblet, Paneth and enteroendocrine secretory cell lineages in both the colon and small intestine at 4 weeks of age, paralleled by a distortion of the proliferative compartment...
  29. Intestinal satiation in Roux-en-Y gastric bypass rats: brain mechanisms and sex d
    Thomas Alexander Lutz; Fiscal Year: 2013
    ..overall intake is increased intestinal satiation caused by the entry of ingesta more distally into the small intestine, i.e...
  30. Discovery of Vibrio cholerae factors contributing to virulence in Drosophila.
    ALEXANDRA ELIZABETH PURDY; Fiscal Year: 2010
    ..V. cholerae colonizes the small intestine via attachments made by the toxin co-regulated pilus (TCP) and then secretes cholera toxin from this location...
  31. Aldose Reductase: A Regulator of Inflammatory Signals
    KOTA VENKATA RAMANA; Fiscal Year: 2011
    ..LPS-induced inflammatory cytokines and chemokines by AR inhibition will be investigated in the liver, spleen, small intestine, kidney, heart and serum, and correlated with attenuation of inflammation in tissues of mice...
  32. Non-invasive Ultrasound Elasticity Imaging (UEI) in Crohn's Disease
    Jonathan M Rubin; Fiscal Year: 2010
    ..When Crohn's patients have abdominal pain and vomiting, this indicates severe narrowing of the small intestine. This can be due to inflammation, which can be treated with medical therapy, or due to chronic fibrosis, ..
  33. Role of mesenteric lymphatics and dietary endotoxin in metabolic syndrome
    DAVID CARL ZAWIEJA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Although more than 95% of dietary lipids are absorbed from the small intestine via the intestinal lymphatics, transported via the mesenteric collecting lymphatics through the lymphatic network en ..
  34. RENALASE DEFICIENCY AND CARDIOVASCULAR COMPLICATIONS OF CHRONIC KIDNEY DISEASE
    Gary V Desir; Fiscal Year: 2010
    ..along with that secreted into blood by the kidney (although also expressed in heart, skeletal muscle and small intestine), play a key role in regulating blood pressure and cardiovascular function, and that abnormalities in the ..
  35. FOUR-DIMENSIONAL MRI FOR IMAGE-GUIDED RADIATION THERAPY FOR PANCREATIC CANCER
    Yanle Hu; Fiscal Year: 2013
    ..The prescribed dose is limited by the radiation intolerance of adjacent normal organs such as small intestine, duodenum, stomach, kidneys and spinal cord...
  36. Functional Analysis of MGAT Enzymes
    Robert V Farese; Fiscal Year: 2010
    ..Mgat2 is expressed highly in the small intestine and at lower levels in the liver and white adipose tissue (WAT)...
  37. Regulation of Metabolism by the Hormone FGF15/19
    Steven A Kliewer; Fiscal Year: 2013
    ..investigates the biological actions of FGF15/19, a relatively unexplored hormone that is secreted from the small intestine after a meal...
  38. Sweet taste receptors and glucose metabolism in healthy and T2DM humans
    Karen L Teff; Fiscal Year: 2012
    ..receptor (STR) and gustducin, the G protein involved in taste signal transduction are all expressed in the small intestine of humans and other animals...
  39. Ednrb Regulation of Gastrointestinal Motility
    KENT CHARLES WILLIAMS; Fiscal Year: 2013
    ..Signaling through endothelin receptor B (Ednrb) influences motility in the esophagus, stomach, small intestine, and colon...
  40. Using Electrochemical Methods to Probe Neuronal Signaling in the GI Tract
    Greg M Swain; Fiscal Year: 2010
    ..neurotransmitter serotonin (5-HT) and the inhibitory neurotransmitter nitric oxide (NO) be measured in the small intestine and colon of test animals and can the associated neuropharmacology controlling release and clearance be ..
  41. Regulation of Vibrio cholerae motility, stress response and detachment from intes
    ANISIA J SILVA-BENITEZ; Fiscal Year: 2013
    ..studies have focused on those factors that promote detachment of Vibrios, their dissemination throughout the small intestine and return to the aquatic environment...
  42. EPITHELIAL OXALATE AND CITRATE TRANSPORT
    DAVID BRUCE MOUNT; Fiscal Year: 2011
    ..a novel kinase with potent inhibitory effects on both SLC26A2 and SLC26A6, apical oxalate exchangers in the small intestine. This phenotypic characterization will be correlated with the impact of these polymorphisms on the genetic ..
  43. The role of PhoP/PhoQ-regulated phospholipid alterations in Salmonella pathogenes
    ZACHARY DALEBROUX; Fiscal Year: 2013
    ..Following ingestion of contaminated products, bacteria access the human small intestine. Here, typhoidal species traverse the intestinal epithelium and are ingested by resident phagocytes...
  44. Interaction between Vibrio cholerae and Dictylostelium discoideum
    SHELLEY M contact PAYNE; Fiscal Year: 2010
    ..Cholera results from colonization of the small intestine by V. cholerae, where it produces a potent toxin that results in massive water loss and electrolyte imbalance...
  45. Immunologic Basis of Cow's Milk-Induced Hypersensitivities
    Hugh Sampson; Fiscal Year: 2013
    ..and epithelial cell lines, it was shown that IgE and CD23 are required for enhanced allergen uptake in the small intestine and are found in the stool of food-allergic but not non-allergic children, supporting their role in the ..
  46. NSAID-Phosphatidylcholine Association: Insight in GI Ulcer Pathogenesis/Therapy
    Lenard M Lichtenberger; Fiscal Year: 2010
    ..COX) and is exacerbated by bile acids, that are present in high concentration to the lumen of the small intestine, by forming toxic mixed micelles due to their common amphipathic properties...
  47. Rotavirus: Studies of Intestinal Tropism, Viral Entry, and Rescue
    HARRY BERNARD GREENBERG; Fiscal Year: 2013
    ..Infection with RV is predominantly restricted to the villous epithelium of the small intestine. Of note, the basis for host-range restriction of heterologous RV replication in intestinal cells remains ..
  48. Intestinal Lymphocyte Trafficking
    Eugene C Butcher; Fiscal Year: 2013
    ..small intestines, and the role(s) of colon- and small intestine- selective T cell chemoattractant and orphan G protein linked receptors (GPCRs): Short term homing studies ..
  49. Gut bile acids, Fxr, &Fgf15 in total parenteral nutrition-associated cholestasis
    Grace L Guo; Fiscal Year: 2013
    ..have shown that in mice, activation of intestinal Fxr induces fibroblast growth factor 15 (Fgf15) in the small intestine to suppress bile acid synthesis by inhibiting the gene expression of Cyp7a1 that encodes the rate-limiting ..
  50. Mechanisms for Benzo(a)pyrene-Induced Colon Cancer Exacerbation by Dietary Fat
    Aramandla Ramesh; Fiscal Year: 2013
    ..unsaturated dietary fat on B(a)P-induced adenomas and carcinomas in the small intestine and colon of the ApcMin mouse;2...
  51. Role of Gender-associated Microbiota in Organ-specific Autoimmunity
    Martin A Kriegel; Fiscal Year: 2013
    ..Specific Aim 2: To analysis the T cell compartment in the small intestine and colon of male versus female NOD mice...
  52. Role of taste signaling elements in enteroendocrine cells
    Robert F Margolskee; Fiscal Year: 2013
    ..L cells, are required for the release of GLP-1 in response to glucose or sweeteners within the lumen of the small intestine. The experiments proposed to functionally characterize the roles of gustducin and other taste signaling ..
  53. SURGICAL STUDIES OF FUNCTIONAL GENE EXPRESSION
    BERNARD MARK EVERS; Fiscal Year: 2013
    ..Surgical resection of the small intestine results in an adaptive hyperplasia, whereas the inability to provide enteral nutrients, as occurs in certain ..
  54. Multi-level analysis of iron metabolism and treatment of chronic kidney disease
    Paul L Fox; Fiscal Year: 2013
    ..will provide testable insights into the interactions between the key iron homeostatic systems - the small intestine, bone marrow, liver, and marrow...
  55. INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
    MARTIN FREDERICK KAGNOFF; Fiscal Year: 2013
    ..regulation of innate mucosal immune responses by dendritic cells (DC) and epithelial cells in the colon and small intestine. Unit 1 uses an attaching and effacing lesion-inducing enteric pathogen and rotavirus to probe the host ..
  56. Development of a live, genetically-attenuated cholera vaccine prototype that coul
    JORGE ANTONIO BENITEZ; Fiscal Year: 2013
    ..biofilm-derived cells of the modified vaccine to outcompete strain 638 for colonization of the suckling mouse small intestine. In Aim 2, we will use an oral (intragastric) adult rabbit immunization model to compare the immunogenicity ..
  57. Molecular characterization of a hookworm Macrophage Migration Inhibitory Factor
    Jon J Vermeire; Fiscal Year: 2010
    ..survival by effectively modulating the host immune response at the site of attachment within the host small intestine. The immunomodulatory role of AceMIF will be investigated using cell based in vitro assays to elucidate ..
  58. Epithelia Associated Dendritic Cells: Phenotype and Function
    Rodney D Newberry; Fiscal Year: 2010
    ..phenotypic and functional diversity of epithelium associated dendritic cells (EA-DC) from the mouse and human small intestine. The overarching hypothesis of this proposal is that intestinal EA-DC include two subtypes of DCs with ..
  59. Intracellular Calcium Regulated NHE3 Endocytosis
    NICHOLAS CONSTANTINE ZACHOS; Fiscal Year: 2012
    ..In the small intestine, elevation of intracellular calcium ([Ca2+]i) by carbachol (mimics postprandial changes due to cholinergic ..
  60. Intestinal Stem Cell Survival and Renewal Coordinately Regulated by PUMA and p21
    Jian Yu; Fiscal Year: 2013
    ..The small intestine is one of the most sensitive organs to radiation-induced damage, which is the major complication in abdominal ..
  61. NHE3 Polymorphisms and Chronic Diarrheal Diseases
    Xinjun Zhu; Fiscal Year: 2013
    ..804). PUBLIC HEALTH RELEVANCE: Sodium and hydrogen absorption that occurs in small intestine and colon is mainly by regulation of NHE3 activity...
  62. Apical Chloride/Bicarbonate Exchangers in Small Intestine and Kidney
    Manoocher Soleimani; Fiscal Year: 2009
    PROJECT SUMMARY / ABSTRACT Small intestine and kidney tubules play essential roles in the absorption and homeostatic balance of salt and carbohydrates...
  63. Characterization of Innate immune receptors
    Detlef Schuppan; Fiscal Year: 2009
    Celiac disease (Cd) is a T cell mediated disease of the small intestine. It is triggered by dietary gluten proteins from cereals and affects 1 in 130 US citizens...
  64. NEUROENDOCRINE CONTROL OF SMALL INTESTINAL MOTILITY
    Thomas Nowak; Fiscal Year: 1990
    Both the intrinsic nerves and gut neuropeptides are known to regulate muscle contraction and relaxation in the small intestine. However, how nerves and peptides act together to regulate neuromuscular transmission is not well understood...
  65. INTESTINAL AND COLONIC CYTOCHROME P450 GENE EXPRESSION
    Peter Traber; Fiscal Year: 1993
    The epithelial cells lining the small intestine and colon are exposed to many ingested xenobiotics including drugs and environmental carcinogens...
  66. EFFECTS OF BILE ACIDS ON CALCIUM AND IRON ABSORPTION
    Edward Moore; Fiscal Year: 1990
    ..these bile salts on the absorption of ionic calcium (Ca++) and iron (Fe++ and Fe+++) from each region of the small intestine. Of the 3 major divalent cations in human physiology: Ca++, Fe++, and Mg++, only Mg++ is freely soluble at ..
  67. CELLULAR AND MOLECULAR MECHANISMS FOR MUCOSAL IMMUNITY
    Kohtaro Fujihashi; Fiscal Year: 2005
    ..LTbR)-Ig do not develop Peyer's patches ; however, these mice exhibit mesenteric lymph nodes which drain the small intestine. In this regard, oral immunization of LTbR-Ig treated mice with protein and cholera toxin (CT) as mucosal ..
  68. MOLECULAR MODE OF ACTION OF BACTERIAL ENTEROTOXINS
    JOHNNY PETERSON; Fiscal Year: 1999
    ..components in the mechanism of action of cholera toxin (CT) on water and electrolyte secretion in the small intestine. Various mediator responses to CT in the rabbit and porcine models were characterized in the last project ..
  69. SYNAPTIC TRANSMISSION IN DIABETIC ENTERIC NERVOUS SYSTEM
    KATHY LEPARD; Fiscal Year: 2001
    ..enteric neurons will be investigated immunohistochemically by quantifying enzyme and peptide content of the small intestine, functionally by recording contractions/ relaxations from circular/ longitudinal smooth muscle strips of ..
  70. REGULATION OF ADENOSINE DEAMINASE IN SMALL INTESTINE
    Dan Wiginton; Fiscal Year: 2006
    EXCEED THE SPACE PROVIDED. The epithelium of mammalian small intestine has a complex, but highly defined architecture. The primary components of this architecture are the crypt and villus...
  71. Short-Chain Fatty Acid Enhanced Intestinal Adaptation
    KELLY TAPPENDEN; Fiscal Year: 2006
    ..However, medical treatments aimed at increasing the structure and function of the remaining small intestine could allow these children to consume nutrients orally and eliminate their long-term reliance on TPN...
  72. Slowing of Transit - The Third Enteric Function of 5-HT
    Henry Lin; Fiscal Year: 2005
    In order to optimize nutrition, the movement of a meal through the small intestine must be precisely controlled to ensure that there is adequate time to complete the time-demanding steps of digestion and absorption...
  73. PHARMACOLOGY OF DIDEOXYNUCLEOSIDES IN SMALL INTESTINAL
    JESSIE AU; Fiscal Year: 1991
    ..The present proposal is focused on the pharmacology in small intestine. We recently established the methodologies to culture epithelial crypt cells isolated from rat small ..
  74. Mechanisms of intestinal failure in post-surgical inflammatory bowel disease
    PAULINE LUND; Fiscal Year: 2009
    ..Recurrent inflammation, fibrostenotic disease and obstruction in small intestine frequently lead to repeat surgeries, increasing the risk of intestinal failure or short bowel syndrome...
  75. Role of Myosin VI in CFTR Endocytosis in the Intestine
    Nadia Ameen; Fiscal Year: 2007
    ..the first evidence that cAMP and cGMP also regulate surface pools of CFTR and anion secretion in the native small intestine by insertion and trafficking of endosomal CFTR into the plasma membrane of enterocytes...