cecum

Summary

Summary: The blind sac or outpouching area of the LARGE INTESTINE that is below the entrance of the SMALL INTESTINE. It has a worm-like extension, the vermiform APPENDIX.

Top Publications

  1. pmc Immunodesign of experimental sepsis by cecal ligation and puncture
    Daniel Rittirsch
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, Michigan 48109, USA
    Nat Protoc 4:31-6. 2009
  2. ncbi Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine
    Blair B Madison
    Department of Cell and Developmental Biology, The University of Michigan Medical School, Ann Arbor, Michigan 48109 0616, USA
    J Biol Chem 277:33275-83. 2002
  3. ncbi Voluntary running exercise alters microbiota composition and increases n-butyrate concentration in the rat cecum
    Megumi Matsumoto
    Laboratory of Nutritional Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Hokkaido 060 8589, Japan
    Biosci Biotechnol Biochem 72:572-6. 2008
  4. ncbi Glycan foraging in vivo by an intestine-adapted bacterial symbiont
    Justin L Sonnenburg
    Center for Genome Sciences, Washington University, St Louis, MO 63108, USA
    Science 307:1955-9. 2005
  5. pmc Candida albicans and bacterial microbiota interactions in the cecum during recolonization following broad-spectrum antibiotic therapy
    Katie L Mason
    Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Infect Immun 80:3371-80. 2012
  6. pmc Immune response of chicken gut to natural colonization by gut microflora and to Salmonella enterica serovar enteritidis infection
    Magdalena Crhanova
    Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic
    Infect Immun 79:2755-63. 2011
  7. ncbi An obesity-associated gut microbiome with increased capacity for energy harvest
    Peter J Turnbaugh
    Center for Genome Sciences, Washington University, St Louis, Missouri 63108, USA
    Nature 444:1027-31. 2006
  8. pmc Chicken cecum immune response to Salmonella enterica serovars of different levels of invasiveness
    Angela Berndt
    Friedrich Loeffler Institute, Institute of Molecular Pathogenesis, Naumburger Str 96a, D 07743 Jena, Germany
    Infect Immun 75:5993-6007. 2007
  9. ncbi The pattern of neural crest advance in the cecum and colon
    Noah R Druckenbrod
    Department of Anatomy, and Neuroscience Training Program, University of Wisconsin Medical School, Madison, WI 53706, USA
    Dev Biol 287:125-33. 2005
  10. pmc Genomic and metabolic studies of the impact of probiotics on a model gut symbiont and host
    Justin L Sonnenburg
    Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Biol 4:e413. 2006

Detail Information

Publications269 found, 100 shown here

  1. pmc Immunodesign of experimental sepsis by cecal ligation and puncture
    Daniel Rittirsch
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, Michigan 48109, USA
    Nat Protoc 4:31-6. 2009
    ..The CLP procedure can be performed in as little as 10 min for each animal by an experienced user, with additional time required for subsequent postoperative care and data collection...
  2. ncbi Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine
    Blair B Madison
    Department of Cell and Developmental Biology, The University of Michigan Medical School, Ann Arbor, Michigan 48109 0616, USA
    J Biol Chem 277:33275-83. 2002
    ..of beta-galactosidase activity in restricted domains of the small intestine (duodenum) and large intestine (cecum). In addition, expression is reduced in the crypt compartment throughout the intestine...
  3. ncbi Voluntary running exercise alters microbiota composition and increases n-butyrate concentration in the rat cecum
    Megumi Matsumoto
    Laboratory of Nutritional Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Hokkaido 060 8589, Japan
    Biosci Biotechnol Biochem 72:572-6. 2008
    ..This alteration of the cecal microbial environment may contribute to the beneficial effect of exercise on gastrointestinal disorders...
  4. ncbi Glycan foraging in vivo by an intestine-adapted bacterial symbiont
    Justin L Sonnenburg
    Center for Genome Sciences, Washington University, St Louis, MO 63108, USA
    Science 307:1955-9. 2005
    ..This flexible foraging behavior should contribute to ecosystem stability and functional diversity...
  5. pmc Candida albicans and bacterial microbiota interactions in the cecum during recolonization following broad-spectrum antibiotic therapy
    Katie L Mason
    Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Infect Immun 80:3371-80. 2012
    ..albicans during antibiotic treatment does not trigger overt inflammation in the murine cecum. Bacterial diversity is reduced long term following cefoperazone treatment, but the presence of C...
  6. pmc Immune response of chicken gut to natural colonization by gut microflora and to Salmonella enterica serovar enteritidis infection
    Magdalena Crhanova
    Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic
    Infect Immun 79:2755-63. 2011
    ..For the first 3 days of life, chicken cecum was protected by increased expression of chicken β-defensins (i.e...
  7. ncbi An obesity-associated gut microbiome with increased capacity for energy harvest
    Peter J Turnbaugh
    Center for Genome Sciences, Washington University, St Louis, Missouri 63108, USA
    Nature 444:1027-31. 2006
    ..These results identify the gut microbiota as an additional contributing factor to the pathophysiology of obesity...
  8. pmc Chicken cecum immune response to Salmonella enterica serovars of different levels of invasiveness
    Angela Berndt
    Friedrich Loeffler Institute, Institute of Molecular Pathogenesis, Naumburger Str 96a, D 07743 Jena, Germany
    Infect Immun 75:5993-6007. 2007
    ..The localization of Salmonella organisms in gut mucosa and the number of immune cells in cecum were determined by immunohistochemistry in the period between 4 h and 9 days after infection...
  9. ncbi The pattern of neural crest advance in the cecum and colon
    Noah R Druckenbrod
    Department of Anatomy, and Neuroscience Training Program, University of Wisconsin Medical School, Madison, WI 53706, USA
    Dev Biol 287:125-33. 2005
    ..With respect to the entire gut, we have found that ENCCs in the cecum and proximal colon behave uniquely...
  10. pmc Genomic and metabolic studies of the impact of probiotics on a model gut symbiont and host
    Justin L Sonnenburg
    Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Biol 4:e413. 2006
    ..Although the overall transcriptome expressed by B. thetaiotaomicron when it encounters B. longum in the cecum is dependent upon the genetic background of the mouse (as assessed by a mixed analysis of variance [ANOVA] model ..
  11. pmc Diversity and succession of the intestinal bacterial community of the maturing broiler chicken
    Jiangrang Lu
    Department of Avian Medicine Department of Pathology, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602, USA
    Appl Environ Microbiol 69:6816-24. 2003
    ..5%). In contrast, Clostridiaceae-related sequences (65%) were the most abundant group detected in the cecum, with the other most abundant sequences being related to Fusobacterium (14%), Lactobacillus (8%), and Bacteroides (..
  12. pmc 16S rRNA-based analysis of microbiota from the cecum of broiler chickens
    Xiang Y Zhu
    Department of Animal and Food Sciences, University of Delaware, Newark, Delaware 19717 1301, USA
    Appl Environ Microbiol 68:124-37. 2002
    ..Earlier culturing and microscopic examinations indicated that only a fraction of the bacteria in the cecum of chickens could be grown in the laboratory...
  13. ncbi Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats
    Patrice D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Department of Pharmaceutical Sciences, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Br J Nutr 92:521-6. 2004
    ....
  14. pmc Community-wide response of the gut microbiota to enteropathogenic Citrobacter rodentium infection revealed by deep sequencing
    Christian Hoffmann
    University of Pennsylvania School of Medicine, Department of Microbiology, Philadelphia, PA 19104, USA
    Infect Immun 77:4668-78. 2009
    ..101,894 partial 16S rRNA gene sequences from 85 microbial samples from tissue-adhered and luminal bacteria of the cecum, proximal colon, and distal colon, which allowed us to identify previously unappreciated spatial and kinetic ..
  15. ncbi Phage therapy reduces Campylobacter jejuni colonization in broilers
    Jaap A Wagenaar
    Division of Infectious Diseases, Animal Sciences Group, P O Box 65, 8200 AB Lelystad, The Netherlands
    Vet Microbiol 109:275-83. 2005
    ..This again resulted in a significant decrease in Campylobacter colonization. We conclude that phage treatment is a promising alternative for reducing C. jejuni colonization in broilers...
  16. ncbi Cecal ligation and puncture as a model of sepsis in the rat: influence of the puncture size on mortality, bacteremia, endotoxemia and tumor necrosis factor alpha levels
    E Otero-Anton
    Department of Medicine, Complejo Hospitalario Universitario, Santiago de Compostela, Spain
    Eur Surg Res 33:77-9. 2001
    ..Cecal ligation and puncture is a widely used experimental model of sepsis...
  17. pmc Influence of Salmonella enterica serovar enteritidis infection on the development of the cecum microbiota in newly hatched chicks
    H Juricova
    Veterinary Research Institute, Hudcova, Brno, Czech Republic
    Appl Environ Microbiol 79:745-7. 2013
    ..Salmonella enterica serovar Enteritidis infection caused the greatest changes in the gut microbiota when 1-day-old chicks were infected, compared with the infection of 4- and 16-day-old chicks...
  18. pmc Genomic diversity and relatedness of bifidobacteria isolated from a porcine cecum
    P J Simpson
    Teagasc, Dairy Products Research Centre, Moorepark, Fermoy, County Cork, Ireland
    J Bacteriol 185:2571-81. 2003
    ..involved the isolation of a number of bifidobacteria from either the lumen or the epithelium of a porcine cecum. A total of 160 isolates were selected at random on MRS plates containing cysteine hydrochloride (0...
  19. pmc Multivariate analysis of complex DNA sequence electropherograms for high-throughput quantitative analysis of mixed microbial populations
    Pål Trosvik
    Centre for Ecological and Evolutionary Synthesis, Department of Biology, University of Oslo, Oslo, Norway
    Appl Environ Microbiol 73:4975-83. 2007
    ..The method presented here is, however, applicable to any experimental scenario where the interest is quantification of GCUs in genetically heterogeneous DNA samples...
  20. ncbi Multiple enhancers regulate Hoxd genes and the Hotdog LncRNA during cecum budding
    Saskia Delpretti
    School of Life Sciences, Ecole Polytechnique Federale, Lausanne CH 1015, Switzerland
    Cell Rep 5:137-50. 2013
    Hox genes are required for the development of the intestinal cecum, a major organ of plant-eating species...
  21. pmc Lipopolysaccharide clearance, bacterial clearance, and systemic inflammatory responses are regulated by cell type-specific functions of TLR4 during sepsis
    Meihong Deng
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 190:5152-60. 2013
    ....
  22. pmc Hemodynamic changes in the kidney in a pediatric rat model of sepsis-induced acute kidney injury
    Kathryn A Seely
    Dept of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 West Markham St, 611, Little Rock, AR 72205, USA
    Am J Physiol Renal Physiol 301:F209-17. 2011
    ..Lower RBF and reduced peritubular capillary perfusion in the pup suggest the pediatric kidney may be more susceptible to AKI than would be predicted using adults models...
  23. pmc T-2 toxin induced Salmonella Typhimurium intoxication results in decreased Salmonella numbers in the cecum contents of pigs, despite marked effects on Salmonella-host cell interactions
    Elin Verbrugghe
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium
    Vet Res 43:22. 2012
    ..83 μg T-2 toxin per kg feed significantly decreased the amount of Salmonella Typhimurium bacteria present in the cecum contents, and a tendency to a reduced colonization of the jejunum, ileum, cecum, colon and colon contents was ..
  24. pmc Genome sequence of Lactobacillus salivarius SMXD51, a potential probiotic strain isolated from chicken cecum, showing anti-campylobacter activity
    Gilles Kergourlay
    LUNAM Université, ONIRIS, UMR1014 Secalim, Nantes, France
    J Bacteriol 194:3008-9. 2012
    We report the draft genome sequence of Lactobacillus salivarius SMXD51, isolated from the cecum of healthy chickens showing an activity against Campylobacter--the food-borne pathogen that is the most common cause of gastroenteritis in ..
  25. pmc Modulations of the chicken cecal microbiome and metagenome in response to anticoccidial and growth promoter treatment
    Jessica L Danzeisen
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota, United States of America
    PLoS ONE 6:e27949. 2011
    ..Overall, this study provides a more comprehensive glimpse of the chicken cecum microbial community, the modulations of this community in response to growth promoters, and targets for future ..
  26. pmc A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model
    Jorge G Ganopolsky
    W M Keck Center for Transgene Research, Department of Chemistry and Biochemistry, 434 Stepan Hall of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    Am J Pathol 165:1433-46. 2004
    ..Thus, the hemodynamic role of PC during sepsis is of critical importance to the outcome of the disease...
  27. ncbi Excretion of bisphenol A-glucuronide into the small intestine and deconjugation in the cecum of the rat
    Hirokazu Sakamoto
    Department of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, 582 1 Bunkyodai Midorimachi, Ebetsu, Hokkaido 069 8501, Japan
    Biochim Biophys Acta 1573:171-6. 2002
    ..of the bisphenol A-glucuronide (BPA-GA) excreted into the small intestine was deconjugated in the contents of the cecum. After BPA administration, BPA-GA was (immediately should be 15 min) found in the contents of the upper part of ..
  28. ncbi Papillary adenocarcinoma arising in a duplication of the cecum
    Jiwon Lee
    Department of Radiology, Kangwon National University College of Medicine, 192 1 Hyoja 2 Dong, Chuncheon si, Kangwon Do, 200 701, South Korea
    Abdom Imaging 33:601-3. 2008
    ..We describe a papillary adenocarcinoma, arising from a duplication of the colon, seen as a cyst with an enhancing papillary projection nodule located adjacent to the wall of the ascending colon and cecum on computed tomography.
  29. pmc Gene expression profiling of the local cecal response of genetic chicken lines that differ in their susceptibility to Campylobacter jejuni colonization
    Xianyao Li
    Department of Poultry Science, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 5:e11827. 2010
    ..To our knowledge, this is the first time each of these responses has been observed in the avian response to an intestinal bacterial pathogen...
  30. pmc The Salmonella enterica serotype Typhimurium lpf, bcf, stb, stc, std, and sth fimbrial operons are required for intestinal persistence in mice
    Eric H Weening
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Ave, Davis, CA 95616 8645, USA
    Infect Immun 73:3358-66. 2005
    ..enterica serotype Typhimurium to colonize the spleen and cecum of BALB/c mice 5 days after infection...
  31. pmc Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Am J Pathol 177:1834-47. 2010
    ..as shown by reduced systemic release of pro-inflammatory cytokines and neutrophil infiltration in lung, liver, and cecum, when compared with vehicle treatment...
  32. ncbi Preabsorptive metabolism of sodium arsenate by anaerobic microbiota of mouse cecum forms a variety of methylated and thiolated arsenicals
    Tatyana S Pinyayev
    Microbiological and Chemical Exposure Assessment Research Division, National Exposure Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Cincinnati, OH 45268, United States
    Chem Res Toxicol 24:475-7. 2011
    ..Here, we report that in vitro anaerobic microbiota of mouse cecum converts arsenate into oxy- and thio- arsenicals...
  33. ncbi Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosis
    Guntram A Grassl
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
    Gastroenterology 134:768-80. 2008
    ..Here, we present a novel murine model of severe and persistent intestinal fibrosis caused by chronic bacterial-induced colitis...
  34. ncbi NF-kappaB and p38 MAPK inhibition improve survival in endotoxin shock and in a cecal ligation and puncture model of sepsis in combination with antibiotic therapy
    Adrian W O'Sullivan
    Department of Academic Surgery, University College Hospital, Cork, Ireland
    J Surg Res 152:46-53. 2009
    ..In this study, we set out to examine the effects of inhibition of p38 MAPK and NF-kappaB translation in in vivo models of sepsis...
  35. pmc Ecological succession of bacterial communities during conventionalization of germ-free mice
    Merritt G Gillilland
    Division of Pulmonary and Critical Care Medicine, The University of Michigan Medical School, Ann Arbor, Michigan, USA
    Appl Environ Microbiol 78:2359-66. 2012
    ..GI) tract; thus, we measured changes in bacterial communities over time, at two different mucosal sites (cecum and jejunum), with germfree C57BL/6 mice as the recipients of cecal contents (input community) from a C57BL/6 ..
  36. ncbi The paternal effect of Campylobacter jejuni colonization in ceca in broilers
    X Li
    Department of Poultry Science, Texas A and M University, College Station 77843, USA
    Poult Sci 87:1742-7. 2008
    ..jejuni counts in cloacal swabs and those in cecal contents. The results indicated that a paternal effect might be one of the important genetic factors influencing resistance to C. jejuni colonization in broilers...
  37. pmc Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies
    Christian Maaser
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Infect Immun 72:3315-24. 2004
    ..human enteropathogenic Escherichia coli, predominantly colonizes the lumen and mucosal surface of the colon and cecum and causes crypt hyperplasia and mucosal inflammation. Mice infected with C...
  38. pmc Characterization of two putative cytochrome c peroxidases of Campylobacter jejuni involved in promoting commensal colonization of poultry
    Lacey K Bingham-Ramos
    University of Texas Southwestern Medical Center, Department of Microbiology, 5323 Harry Hines Boulevard, Dallas, TX 75390 9048, USA
    Infect Immun 76:1105-14. 2008
    ..a putative cytochrome c peroxidase (CCP), demonstrates up to a 10(5)-fold reduction in colonization of the chick cecum compared to wild-type C. jejuni strain 81-176...
  39. ncbi Microflora ecology of the chicken intestine using 16S ribosomal DNA primers
    E Amit-Romach
    The Faculty of Agricultural, Food and Environmental Quality Sciences, Hebrew University of Jerusalem, PO Box 12, Rehovot, 76100, Israel
    Poult Sci 83:1093-8. 2004
    ..coli species were found in the ceca. This study has demonstrated the use of molecular techniques for determining relative proportions of bacterial species and monitoring pathogens in the chick gastrointestinal tract...
  40. ncbi Modulation of the phosphoinositide 3-kinase pathway alters innate resistance to polymicrobial sepsis
    David L Williams
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, PO Box 70575, Johnson City, TN 37614, USA
    J Immunol 172:449-56. 2004
    ..This suggests that stimulation of the PI3K pathway may be an effective approach for preventing or treating sepsis and/or septic shock...
  41. ncbi Cecal ligation and puncture versus colon ascendens stent peritonitis: two distinct animal models for polymicrobial sepsis
    Stefan Maier
    Department of Surgery, Ernst Moritz Arndt Universitat, Greifswald, Germany
    Shock 21:505-11. 2004
    ..CLP procedure was performed puncturing once (CLP[1]) or twice (CLP[2]) the ligated cecum of C57BL/6 mice. In the CASP model, a stent with defined diameter was surgically inserted into the ascending colon...
  42. pmc Identification of Ruminococcus flavefaciens as the predominant cellulolytic bacterial species of the equine cecum
    V Julliand
    Laboratoire associé de Recherches Zootechniques INRA ENESAD, 21036 Dijon Cedex, France
    Appl Environ Microbiol 65:3738-41. 1999
    ..oligonucleotide probes showed that Ruminococcus flavefaciens was the predominant species in the pony and donkey cecum. Fibrobacter succinogenes and Ruminococcus albus were present at low levels...
  43. ncbi Fluorescence in situ hybridization analysis of hindgut bacteria associated with the development of equine laminitis
    Gabriel J Milinovich
    Australian Equine Laminitis Research Unit, School of Veterinary Science, The University of Queensland, Brisbane, QLD, Australia
    Environ Microbiol 9:2090-100. 2007
    ....
  44. pmc Application of methods for identifying broiler chicken gut bacterial species linked with increased energy metabolism
    Valeria A Torok
    SARDI, Plant and Soil Health, Plant Research Centre, Urrbrae, South Australia 5064, Australia
    Appl Environ Microbiol 74:783-91. 2008
    ..Significant diet-associated differences in gut microbial communities were detected within the ileum and cecum only...
  45. ncbi The protective effect of N-acetylcysteine on apoptotic lung injury in cecal ligation and puncture-induced sepsis model
    Ali Ozdulger
    Department of Thoracic and Cardiovascular Surgery, Mersin University School of Medicine, Mersin, Turkey
    Shock 19:366-72. 2003
    ..The chronic use of NAC needs further investigation for its possible antiapoptotic potential in septic states besides its documented antioxidant and antiinflammatory effects...
  46. ncbi Direct stimulation of the transcellular and paracellular calcium transport in the rat cecum by prolactin
    Kamonshanok Kraidith
    Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok, 10400, Thailand
    Pflugers Arch 458:993-1005. 2009
    ..However, little is known regarding its effects on the cecum, a part of the large intestine with the highest rate of intestinal calcium transport...
  47. ncbi Effects of dietary short-chain fructooligosaccharides on the intestinal microflora of horses subjected to a sudden change in diet
    F Respondek
    Beghin Meiji, 67390 Marckolsheim, France
    J Anim Sci 86:316-23. 2008
    ..These data indicate that a scFOS supplementation would be effective in reducing disruptions of the microbial populations in the equine hindgut under stressful situations like acute starch overloads...
  48. ncbi Comparative anatomy and phylogenetic distribution of the mammalian cecal appendix
    H F Smith
    Department of Basic Medical Sciences, University of Arizona College of Medicine Phoenix, in Partnership with Arizona State University, Phoenix, AZ, USA
    J Evol Biol 22:1984-99. 2009
    ..0001) phylogenetic signal in its distribution, and has been maintained in mammalian evolution for 80 million years or longer...
  49. ncbi Increased sarcolemmal permeability as an early event in experimental septic cardiomyopathy: a potential role for oxidative damage to lipids and proteins
    Mara R N Celes
    Department of Pathology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    Shock 33:322-31. 2010
    ....
  50. ncbi Inhibition of NF-kappaB ameliorates sepsis-induced downregulation of aquaporin-2/V2 receptor expression and acute renal failure in vivo
    Klaus Hocherl
    Institut fur Physiologie, Universitat Regensburg, Universitätsstr 31, D 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 298:F196-204. 2010
    ..In addition, our data indicate that NF-kappaB inhibition ameliorates sepsis-induced ARF...
  51. ncbi A newly synthetic vitamin E derivative, E-Ant-S-GS, attenuates lung injury caused by cecal ligation and puncture-induced sepsis in rats
    Yohei Kono
    Department of Gastroenterological Surgery, Oita University Faculty of Medicine, Oita, Japan
    Surgery 151:420-6. 2012
    ....
  52. ncbi Molecular profiling of bacterial species in the rabbit caecum
    Leticia Abecia
    Departamento de Producción Animal y Ciencia de los Alimentos, Universidad de Zaragoza, Spain
    FEMS Microbiol Lett 244:111-5. 2005
    ..Furthermore, most of the sequences clustered together in groups lacking representatives from sequences already described, suggesting that the rabbit caecal flora contains organisms not previously described...
  53. ncbi Ingesting 500 ml of polyethylene glycol solution during capsule endoscopy improves the image quality and completion rate to the cecum
    Hiroki Endo
    Gastroenterology Division, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Dig Dis Sci 53:3201-5. 2008
    ..The capsule reached the cecum in 65.6% of the patients in group A and 88.9% of the patients in group B (P = 0.038)...
  54. pmc Bacteriophage therapy to reduce salmonella colonization of broiler chickens
    R J Atterbury
    Department of Clinical Veterinary Science, University of Bristol, Langford, Bristol BS40 5DU, United Kingdom
    Appl Environ Microbiol 73:4543-9. 2007
    ..The selection of appropriate bacteriophages and optimization of both the timing and method of phage delivery are key factors in the successful phage-mediated control of salmonellas in broiler chickens...
  55. pmc Antibiotic manipulation of intestinal microbiota to identify microbes associated with Campylobacter jejuni exclusion in poultry
    A J Scupham
    Pre Harvest Food Safety and Enteric Diseases Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, Iowa 50010, USA
    Appl Environ Microbiol 76:8026-32. 2010
    ..Examination of the constituents of the derived communities via the array-based method oligonucleotide fingerprinting of rRNA genes detected a subtype of Megamonas hypermegale specific to the C. jejuni-suppressive treatments...
  56. ncbi Increased death receptor pathway of apoptotic signaling in septic mouse aorta: effect of systemic delivery of FADD siRNA
    Naoyuki Matsuda
    Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Am J Physiol Heart Circ Physiol 298:H92-101. 2010
    ..Finally, FADD siRNA administration dramatically improved survival of CLP mice, supporting the feasibility of this gene-based approach for treating septic shock...
  57. pmc Culture-independent microbial community analysis reveals that inulin in the diet primarily affects previously unknown bacteria in the mouse cecum
    Juha H A Apajalahti
    Danisco Innovation, FIN 02460, Kantvik, Finland
    Appl Environ Microbiol 68:4986-95. 2002
    ..Inulin inclusion significantly affected the total bacterial community structure of the cecum as determined by both a nonselective percent-guanine-plus-cytosine-based profiling analysis and a more specific ..
  58. ncbi Degree of polymerization of inulin-type fructans differentially affects number of lactic acid bacteria, intestinal immune functions, and immunoglobulin A secretion in the rat cecum
    Hiroyuki Ito
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka, Japan
    J Agric Food Chem 59:5771-8. 2011
    ..The results show that fructans with lower DP enhance cecal IgA secretion and increase the plasma cells and suggest that the increased lactobacilli may contribute to the stimulation of cecal IgA secretion...
  59. pmc Methyl-2-acetamidoacrylate, an ethyl pyruvate analog, decreases sepsis-induced acute kidney injury in mice
    Asada Leelahavanichkul
    NIH NIDDK, Bldg 10, Rm 3N108, 10 Center Drive, MSC 1268, Bethesda, MD 20892 1268, USA
    Am J Physiol Renal Physiol 295:F1825-35. 2008
    ..Identifying this new target and downstream signaling pathways could lengthen the therapeutic window and improve combination therapy with chloroquine...
  60. ncbi Adhesion and colonization of enterohemorrhagic Escherichia coli O157:H7 in cecum of mice
    Keiji Nagano
    Laboratory of Microbiology, Department of Public Health Pharmacy, Gifu Pharmaceutical University, Gifu, Gifu 502 8585, Japan
    Microbiol Immunol 47:125-32. 2003
    ..The EHEC O157:H7 colonies were found on the epithelial surfaces of the ceca in association with F-actin accumulation beneath the attached bacteria...
  61. ncbi Effect of biotherapeutics on cyclosporin-induced Clostridium difficile infection in mice
    Sukhminderjit Kaur
    Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Gastroenterol Hepatol 25:832-8. 2010
    ..We evaluated the role of cyclosporin in the development of CDAD in the experimental mouse model and studied the effect of probiotic and epidermal growth factor (EGF) as biotherapeutics measures...
  62. ncbi Exploring the in vitro formation of trimethylarsine sulfide from dimethylthioarsinic acid in anaerobic microflora of mouse cecum using HPLC-ICP-MS and HPLC-ESI-MS
    Kevin M Kubachka
    US EPA, ORD, NERL, Microbiological and Chemical Exposure, Assessment Research Division, Cincinnati, OH 45268, USA
    Toxicol Appl Pharmacol 239:137-43. 2009
    ..Recent reports have shown that thiolated arsenicals can be produced by the anaerobic microflora of the mouse cecum, suggesting that metabolism prior to systemic absorption may be a significant determinant of the pattern and ..
  63. ncbi Human cecal bile acids: concentration and spectrum
    James P Hamilton
    Division of Gastroenterology and Hepatology, Department of Medicine, Veterans Affairs Maryland Health Care System and University of Maryland School of Medicine, 22 S Greene Street, Baltimore, MD 21201, USA
    Am J Physiol Gastrointest Liver Physiol 293:G256-63. 2007
    ..In the human cecum, deconjugation and dehydroxylation of bile acids are nearly complete, resulting in most bile acids being in ..
  64. pmc Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis
    Siegfried Hapfelmeier
    Institute of Microbiology, D BIOL, ETH Zurich, CH 8093 Zurich, Switzerland
    J Exp Med 205:437-50. 2008
    ..These results establish that pathogen sampling by DCs is a discrete, and MyD88-independent, step during the initiation of a mucosal innate immune response to bacterial infection in vivo...
  65. ncbi Complement-induced impairment of innate immunity during sepsis
    Markus S Huber-Lang
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 169:3223-31. 2002
    ..These data identify a molecular basis for defective innate immunity involving neutrophils during sepsis...
  66. ncbi The NANETS consensus guideline for the diagnosis and management of neuroendocrine tumors: well-differentiated neuroendocrine tumors of the Jejunum, Ileum, Appendix, and Cecum
    J Philip Boudreaux
    Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Pancreas 39:753-66. 2010
    ..Further studies of novel approaches such as peptide receptor radiotherapy are also warranted...
  67. ncbi Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice
    Q Wang
    Department of Surgery, The Shriners Hospitals for Children, Cincinnati, Ohio 45267 0558, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1013-23. 2001
    ..Increased intestinal permeability during sepsis may be regulated by an interaction between IL-6 and IL-10. Treatment with IL-10 may prevent the increase in mucosal permeability during sepsis...
  68. pmc Interleukin-23 orchestrates mucosal responses to Salmonella enterica serotype Typhimurium in the intestine
    Ivan Godinez
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Ave, Davis, CA 95616 8645, USA
    Infect Immun 77:387-98. 2009
    ..Collectively, our results point to IL-23 as an important player in initiating a T-cell-dependent amplification of inflammatory responses in the intestinal mucosa during serotype Typhimurium infection...
  69. ncbi Interactions of butyric acid- and acetic acid-treated Salmonella with chicken primary cecal epithelial cells in vitro
    Filip Van Immerseel
    Department of Pathology, Bacteriology, and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Avian Dis 48:384-91. 2004
    ..These interactions of S. enteritidis with primary chicken cecal epithelial cells were similar to the interactions with other epithelial cell types...
  70. ncbi Characterization of mucosa-associated bacterial communities of the mouse intestine by terminal restriction fragment length polymorphism: Utility of sampling strategies and methods to reduce single-stranded DNA artifacts
    Estela Costa
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    J Microbiol Methods 78:175-80. 2009
    ..T-RFLP analysis indicated that diverse communities of bacteria are associated with mucosa of the ileum, cecum, and descending colon of mice...
  71. ncbi Effect of β -glucanase and xylanase supplementation of barley- and rye-based diets on caecal microbiota of broiler chickens
    D Jozefiak
    Department of Animal Nutrition and Feed Management, University of Life Sciences in Poznan, Poland
    Br Poult Sci 51:546-57. 2010
    ....
  72. ncbi Phylogenetic analysis of cecal microbiota in chicken by the use of 16S rDNA clone libraries
    Pham Thi Ngoc Lan
    Institute of Biotechnology, National Center for Natural Science and Technology, Hanoi, Vietnam
    Microbiol Immunol 46:371-82. 2002
    The chicken cecum contains a great many bacteria, most of which are strict anaerobes...
  73. ncbi Cecal ligation and puncture
    William J Hubbard
    Department of Surgery and Center for Surgical Research, University of Alabama, Birmingham, AL 35294 0019, USA
    Shock 24:52-7. 2005
    ..The challenge of the small circulating blood volume in rodents can be overcome by using micromethods that enable analysis of small volumes, or alternatively, by using a large number of animals to obtain serial samples...
  74. ncbi Distance of cecum ligated influences mortality, tumor necrosis factor-alpha and interleukin-6 expression following cecal ligation and puncture in the rat
    K D Singleton
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
    Eur Surg Res 35:486-91. 2003
    ..Previous data indicate that the number of punctures made in the cecum and needle size utilized are primary determinants of mortality...
  75. ncbi Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture
    Isaiah R Turnbull
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Shock 19:310-3. 2003
    ..However, high IL-6 was predictive of mortality at any age. Mice appear to have age-dependent responses to intra-abdominal sepsis and to appropriate therapy...
  76. ncbi Characterization of microbial populations and volatile fatty acid concentrations in the jejunum, ileum, and cecum of pigs weaned at 17 vs 24 days of age
    M A Franklin
    Department of Animal Science, University of Tennessee, Knoxville 37901 1071, USA
    J Anim Sci 80:2904-10. 2002
    ..aerobic and anaerobic microflora, lactate, and volatile fatty acid (VFA) concentrations in the jejunum, ileum, and cecum of weanling pigs...
  77. ncbi A proof-of-principle, prospective, randomized, controlled trial demonstrating improved outcomes in scheduled unsedated colonoscopy by the water method
    Felix W Leung
    Research and Medical Services, Sepulveda Ambulatory Care Center, Veterans Affairs Greater Los Angeles Healthcare System, North Hills, California, USA
    Gastrointest Endosc 72:693-700. 2010
    ..An observational study in veterans showed that a novel water method (water infusion in lieu of air insufflation) enhanced cecal intubation and willingness to undergo a repeat scheduled unsedated colonoscopy...
  78. ncbi Maturation of the murine cecal microbiota as revealed by terminal restriction fragment length polymorphism and 16S rRNA gene clone libraries
    Ryoko Kibe
    Department of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, 582 1 Bunkyodai Midorimachi, Ebetsu, Hokkaido 069 8501, Japan
    FEMS Microbiol Lett 235:139-46. 2004
    ..The existence of a large number of yet unidentified bacteria inhabiting the murine cecum was demonstrated by 16S rRNA gene clone libraries...
  79. ncbi Microbial community composition of the ileum and cecum of broiler chickens as revealed by molecular and culture-based techniques
    L Bjerrum
    Danish Institute for Food and Veterinary Research, Arhus N
    Poult Sci 85:1151-64. 2006
    The microbial communities of the ileum and cecum of broiler chickens from a conventional and an organic farm were investigated using conventional culture techniques as well as cloning and sequencing of 16S rRNA genes...
  80. ncbi Oligofructose and long-chain inulin: influence on the gut microbial ecology of rats associated with a human faecal flora
    B Kleessen
    German Institute of Human Nutrition DIfE Potsdam Rehbrucke, Department of Gastrointestinal Microbiology, D 14558 Bergholz Rehbrücke, Germany
    Br J Nutr 86:291-300. 2001
    ..Higher molar proportions of faecal butyrate were observed with all diets that had been supplemented with OF and/or lcIN. Stimulation of butyrate production could be of interest for the prevention of ulcerative colitis and colon cancer...
  81. ncbi Encapsulated Bifidobacteria reduced bacterial translocation in rats following hemorrhagic shock and resuscitation
    Xiangcai Ruan
    Department of Vascular Surgery, The First Affiliated Hospital of Sun Yet Sen University, Guangzhou, China
    Nutrition 23:754-61. 2007
    ..The aim of the present study was to determine the effects of peroral encapsulated Bifidobacteria on intestinal microflora, bacterial translocation (BT), plasma endotoxin, and ileal villi injury in a rat model of hemorrhagic shock...
  82. ncbi Host genes affect intestinal colonisation of newly hatched chickens by Campylobacter jejuni
    Yvonne Boyd
    Institute for Animal Health, Compton, Newbury Berkshire, RG20 7NN, UK
    Immunogenetics 57:248-53. 2005
    ..These data suggest that it might be possible to identify the genes responsible by genetic mapping and candidate gene analysis...
  83. pmc Comparative study of bacterial groups within the human cecal and fecal microbiota
    P Marteau
    INSERM U 290, Paris, France
    Appl Environ Microbiol 67:4939-42. 2001
    ..anaerobes, bifidobacteria, Bacteroides, and members of the Clostridium coccoides group and Clostridium leptum subgroup were lower in the cecum. Facultative anaerobes represented 25% of total bacteria in the cecum versus 1% in the feces.
  84. pmc Comparative metagenomics reveals host specific metavirulomes and horizontal gene transfer elements in the chicken cecum microbiome
    Ani Qu
    Department of Animal Sciences, University of Illinois, Urbana, Illinois, United States of America
    PLoS ONE 3:e2945. 2008
    ..Since we have a very limited understanding of the capabilities of most species present in the cecum, we investigated the role of the microbiome by comparative analyses of both the microbial community structure and ..
  85. ncbi Effects of intestinal microflora on superoxide dismutase activity in the mouse cecum
    Yuu Dobashi
    Laboratory of Experimental Animal Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180 8602, Japan
    Exp Anim 60:133-9. 2011
    ..In the cecum, the influence of intestinal microflora on SOD activity is unknown...
  86. pmc Escherichia coli O157:H7 causes more-severe systemic disease in suckling piglets than in colostrum-deprived neonatal piglets
    E A Dean-Nystrom
    Enteric Diseases and Food Safety Research Unit, National Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Ames, Iowa 50010 0070, USA
    Infect Immun 68:2356-8. 2000
    ..Shiga toxin-negative O157:H7 did not cause neurological disease but colonized and caused attaching-and-effacing intestinal lesions...
  87. ncbi Production of two bacteriocins in various growth conditions produced by gram-positive bacteria isolated from chicken cecum
    Qiuju Wang
    College of Animal Science and Veterinary, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province, People s Republic of China
    Can J Microbiol 58:93-101. 2012
    ..Carbon and nitrogen sources affected the antibacterial activities of the two bacteriocins in different combinations, which suggested that the antibacterial abilities of different bacteriocins produced in nutrient sources were various...
  88. ncbi P2Y(1) knockout mice lack purinergic neuromuscular transmission in the antrum and cecum
    V Gil
    Department of Cell Biology, Physiology and Immunology and Neuroscience Institute, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Neurogastroenterol Motil 25:e170-82. 2013
    ..The aim of the present study was to test whether P2Y(1) receptors are involved in purinergic neurotransmission in the antrum and cecum.
  89. pmc Soluble fiber dextrin and soluble corn fiber supplementation modify indices of health in cecum and colon of Sprague-Dawley rats
    Brenda K Knapp
    Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
    Nutrients 5:396-410. 2013
    ..to evaluate health outcomes resulting from dietary supplementation of novel, low-digestible carbohydrates in the cecum and colon of Sprague-Dawley rats randomly assigned to one of four treatment groups for 21 days: 5% cellulose (..
  90. ncbi Cross-linked poly (gamma-glutamic acid) attenuates peritoneal adhesion in a rat model
    Yotaro Izumi
    Department of Surgery, Division of General Thoracic Surgery, School of Medicine, Keio University, Tokyo, Japan
    Surgery 141:678-81. 2007
    ..XL absorbs large amounts of fluid and forms a biodegradable viscous hydrogel. In the present study, we evaluated the anti-adhesive effect of XL in a rat abdominal wall defect and cecal abrasion model...
  91. ncbi Dietary high fluorine induces apoptosis and alters Bcl-2, Bax, and caspase-3 protein expression in the cecal tonsil lymphocytes of broilers
    Juan Liu
    Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya an 625014 Sichuan, China
    Biol Trace Elem Res 152:25-30. 2013
    ....
  92. ncbi A phenoxazine compound, 2-amino-4,4alpha-dihydro-4alpha-7-dimethyl-3H-phenoxazine-3-one reverses the phenylephrine or high-K+ induced contraction of smooth muscles in rat aorta and guinea pig tenia cecum
    Saifuding Musha
    Department of Physiology, Tokyo Medical University, Tokyo 460 8402, Japan
    Biol Pharm Bull 28:1521-3. 2005
    ..Phx-1) reversed concentration dependently the contraction of both rat aorta and guinea pig tenia cecum induced by phenylephrine or high-K(+)...
  93. ncbi Efficacy of a commercial competitive exclusion product against Campylobacter jejuni
    M Hakkinen
    National Veterinary and Food Research Institute, Helsinki, Finland
    Br Poult Sci 40:619-21. 1999
    ..The percentage of colonised birds varied from 0% to 62% in the treated groups and was 100% in the control groups. The average number of campylobacter was considerably lower in the treated groups than in the control groups...
  94. pmc Analysis of the contribution of Salmonella pathogenicity islands 1 and 2 to enteric disease progression using a novel bovine ileal loop model and a murine model of infectious enterocolitis
    Brian K Coombes
    Michael Smith Laboratories, 301 2185 East Mall, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    Infect Immun 73:7161-9. 2005
    ..These data delineate novel phenotypes for SPI-1 and SPI-2 mutants in the intestinal phase of bovine and murine salmonellosis and provide working models to further investigate the effector contribution to these pathologies...
  95. ncbi Relationship between cytokine mRNA expression and organ damage following cecal ligation and puncture
    Rong Qian Wu
    Institute of Surgical Research, General Hospital of PLA, Beijing 100853, China
    World J Gastroenterol 8:131-4. 2002
    ..To investigate the role of cytokine gene expression in organ damage at different tissue sites during sepsis...
  96. ncbi Radial and axial variations of bacteria within the cecum and proximal colon of guinea pigs revealed by PCR-DGGE
    Toru Takahashi
    Faculty of Bioresources, Mie University, Tsu 514 8507, Japan
    Biosci Biotechnol Biochem 69:1790-2. 2005
    We investigated the local variability of bacterial species within the lumen of the cecum and proximal colon of guinea pigs by using PCR-denaturing gradient gel electrophoresis (DGGE)...
  97. pmc Prolonged impact of antibiotics on intestinal microbial ecology and susceptibility to enteric Salmonella infection
    Amy Croswell
    Department of Pediatrics, Division of Gastroenterology, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Infect Immun 77:2741-53. 2009
    ....
  98. ncbi Abscess and cecum carcinoma in inguinal hernia: case report
    G Benfatto
    University School of Catania, Italy
    G Chir 27:262-4. 2006
    ..A primary adenocarcinoma of the cecum in a right sided inguinal hernia is presented and discussed...
  99. ncbi Evaluation of postoperative peritoneal adhesion formation following perioperative nicotine administration
    Eoghan T Condon
    Department of Academic Surgery, National University of Ireland Cork, Cork, Ireland
    J Surg Res 140:135-8. 2007
    ..The objective of this study was to evaluate the effect of nicotine on postlaparotomy abdominal adhesions...
  100. ncbi The importance of recognizing increased cecal inflammation in health and avoiding the misdiagnosis of nonspecific colitis
    Shirley C Paski
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 102:2294-9. 2007
    An inherent degree of nonpathological mild inflammation in the cecum has been described informally among pathologists. This low-grade inflammation is often reported as "nonspecific colitis," which can confuse clinicians...
  101. ncbi Blebbistatin, a myosin II inhibitor, suppresses contraction and disrupts contractile filaments organization of skinned taenia cecum from guinea pig
    Masaru Watanabe
    Dept of Physiology, Tokyo Medical Univ, Japan
    Am J Physiol Cell Physiol 298:C1118-26. 2010
    ..structure of contractile filaments of skinned (cell membrane permeabilized) preparations from guinea pig taenia cecum. Blebbistatin at 10 microM or higher suppressed Ca(2+)-induced tension development at any given Ca(2+) ..

Research Grants63

  1. Localization and characterization of the Clostridium difficile biofilm
    Adam Driks; Fiscal Year: 2013
    ..difficile forms communities at the mucosa of the cecum and colon in mice with CDI, indicating that C. difficile forms a biofilm in the host. C...
  2. Intestinal Calcium Absorption: Molecular Mechanism
    James C Fleet; Fiscal Year: 2012
    ..vitamin D resistance (subaim1a) and we will determine whether the deletion of VDR specifically from the ileum, cecum, and colon can alter whole body calcium metabolism (subaim1b), (2) To determine whether the apical membrane Ca ..
  3. Impact of corn grind diameter and housing environment on performance and presence
    Kenneth Anderson; Fiscal Year: 2013
    ..tissues will be aseptically collected: spleen, hen reproductive tract (ovaries and/or uterovaginal region) and cecum. These tissues will be stored in sterile ice cold buffered peptone water in stomacher bags and processed at the ..
  4. Role of SR-BI in LPS detoxification
    Xiang An Li; Fiscal Year: 2012
    ..More importantly, using a cecum ligation and puncture (CLP) septic model, we demonstrate that CLP treatment induced 100% fatality of SR-BI null ..
  5. Symbiosis of E. coli and the Intestinal Microbiota in a Mouse Model
    Tyrrell Conway; Fiscal Year: 2013
    ..Importantly, we learned that E. coli respires oxygen and thereby lowers the oxygen tension of the cecum, creating conditions that favor growth of the predominantly anaerobic microbial community...
  6. Metabolic adaptation of Citrobacter during pathogenic colonization of the gut
    KRISTIE MILLER KEENEY; Fiscal Year: 2012
    ..2. The route of infection with C. rodentium begins by ingestion, followed by early colonization of the cecum and subsequent colonization of the colon...
  7. Genetic Determinants of Mucosal Defense to Salmonella Infection
    Kelly D Smith; Fiscal Year: 2010
    ..A/J mice develop rapid colonization of the cecum followed by chronic persistent infection and inflammation...
  8. Prevention & Metastasis: Final Frontiers in Colon Cancer
    Robert Coffey; Fiscal Year: 2009
    ..mouse models of CRC that we have identified - a colony of Smad3 null mice that develop tumors only in the cecum and carcinogen-treated MOLF mice that develop sessile (flat) colonic tumors...
  9. Duodenal Mucosal Defense Mechanisms
    Jonathan D Kaunitz; Fiscal Year: 2013
    ..ensure that digestion and absorption of nutrients is unimpeded, bacterial replications must be limited until the cecum is reached...
  10. CDX2 TUMOR SUPPRESSOR PATHWAY DEFECTS IN COLON CANCER
    Eric R Fearon; Fiscal Year: 2013
    ..period, we described novel CDX2P-Cre transgenic mice and their use for somatic inactivation of the Apc TSG in cecum, colon and rectum, leading to new models of colonic adenoma-carcinoma progression...
  11. Virtual Fly-Over Colonoscopy System for Clinical Test-SBIR Phase 1
    SALWA A ELSHAZLY; Fiscal Year: 2013
    ..Furthermore, even experienced endoscopists may have difficulty reaching the cecum, resulting in incomplete visualizations of the colon...
  12. Intervention strategies of hemorrhagic colitis and HUS
    Edgar Boedeker; Fiscal Year: 2004
    ..is an attaching and effacing rabbit pathogen which produces high levels of Shiga-like toxin I (Stx-I), colonizes cecum and colon, and induces intestinal disease in rabbits with pathologic changes resembling human EHEC disease...
  13. WATER AND ELECTROLYTE TRANSPORT BY THE INTESTINE
    KENNETH HUBEL; Fiscal Year: 1990
    ..reduces chloride absorption in human ileum and sigmoid colon, and causes secretion of chloride in jejunum and cecum. Tests of 3 hypotheses will be continued: 1) Stimuli (chemical or mechanical) that evoke changes in transport do ..
  14. Mouse Strain dependent innate resistance to intestinal amebiasis
    Eric Houpt; Fiscal Year: 2009
    ..Aim 2 will characterize the anatomy of TLR expression in the mouse cecum and the pattern of amoeba-induced TLR activation in vitro...
  15. Insulin Resistance and Adenomas of the Colorectum
    RALPH DAGOSTINO; Fiscal Year: 2003
    ..Mucosal biopsies will be taken from the cecum and rectum of all subjects, and all adenomas will be removed and examined for histologic features, Ki-ras ..
  16. Insulin Resistance and Adenomas of the Colorectum
    Theodore Levin; Fiscal Year: 2003
    ..Mucosal biopsies will be taken from the cecum and rectum of all subjects, and all adenomas will be removed and examined for histologic features, Ki-ras ..
  17. Insulin Resistance and Adenomas of the Colorectum
    Steven Haffner; Fiscal Year: 2003
    ..Mucosal biopsies will be taken from the cecum and rectum of all subjects, and all adenomas will be removed and examined for histologic features, Ki-ras ..
  18. Insulin Resistance and Adenomas of the Colorectum
    Mohammed Saad; Fiscal Year: 2003
    ..Mucosal biopsies will be taken from the cecum and rectum of all subjects, and all adenomas will be removed and examined for histologic features, Ki-ras ..
  19. Insulin Resistance and Adenomas of the Colorectum
    Tim Byers; Fiscal Year: 2003
    ..Mucosal biopsies will be taken from the cecum and rectum of all subjects, and all adenomas will be removed and examined for histologic features, Ki-ras ..
  20. TREATMENT INTERVENTIONS FOR HEMORRHAGIC COLITIS
    Edgar Boedeker; Fiscal Year: 1999
    ..This strain produces high levels of Shiga-like toxin I (SLT-I), colonizes cecum and colon, and induces intestinal disease in rabbits with pathologic changes resembling human EHEC disease...
  21. INTERVENTIONAL STRATEGIES FOR HEMORRHAGIC COLITIS
    Edgar Boedeker; Fiscal Year: 2000
    ..This strain produces high levels of Shiga-like toxin I (SLT-I), colonizes cecum and colon, and induces intestinal disease in rabbits with pathologic changes resembling human EHEC disease...
  22. BRAIN/PELVIC VISCERA INTERACTIONS IN PSYCHIATRIC DISEASE
    RITA VALENTINO; Fiscal Year: 2001
    ..Transsynaptic tracing (using pseudorabies virus) from the colon, cecum and bladder will be combined with retrograde tract tracing from the LC to determine whether Barrington's LC-..
  23. PROXIMAL COLON--A DISTINCT TRANSPORT EPITHELIUM
    Joseph Sellin; Fiscal Year: 1993
    ..The gut demonstrates a significant segmental heterogeneity in its mechanisms of Na absorption. The cecum exhibits a high rate of electrogenic Na absorption, neither coupled to anions or nutrients, nor blocked by ..
  24. PREVENTION OF POSTSURGICAL ADHESIONS
    James Pachence; Fiscal Year: 2000
    ..Adhesions were first created along the abdominal wall, cecum, and right uterine horn; the adhesions were confirmed, than lyzed, prior to application of the test compounds...
  25. Treatment of Surgical Sepsis with AM/AMBP-1
    Rongqian Wu; Fiscal Year: 2005
    ..In addition, a 10-day survival study will be conducted following CLP and surgical removal of the necrotic cecum. The proposed studies should provide useful feasibility information that will allow us to further develop AM/AMBP-..
  26. ROLE OF PROXIMAL COLONIC LYMPHOID TISSUE IN IMMUNITY
    Greg Perry; Fiscal Year: 1991
    ..This evidence includes: 1) A total lack of B cells in infants born without a terminal ileum, cecum and proximal colon, 2) Ly-1 immunoregulatory B cells are derived from an abdominal (not bone marrow) source, 3) ..
  27. Intestinal Bacteria and Rabbit Antibody Diversification
    Dennis Lanning; Fiscal Year: 2006
    ..Studies of germ-free rabbits and of rabbits in which the cecum was ligated at birth to prevent entry of intestinal contents into the appendix have shown that GALT development is ..
  28. PARACELLULAR CALCIUM ABSORPTION--A NEW APPROACH
    David Lee; Fiscal Year: 2000
    ..complemented by in vitro transepithelial transport studies using natural epithelium from duodenum, jejunum, ileum, cecum, colon and monolayers of the IEC6, IEC18, T84 and Caco-2 cell lines...
  29. Improving colonoscopic miss rate by real time microvascular blood analysis
    Hemant Roy; Fiscal Year: 2009
    ..Furthermore, it would aid in the relatively common scenarios such as inability to reach cecum or mucosal obscuration by residual stool...
  30. MOLECULAR GENETIC ANALYSIS OF SALMONELLA PATHOGENICITY
    Roy Curtiss; Fiscal Year: 2006
    ..to specific cell types and tissues in the murine host, in enabling long-term colonization of the intestine and cecum in chicks, and in contributing to surface colonization (biofilm formation) in the simulated polluted water medium ..
  31. ORTHOTOPIC HUMAN TUMOR IMPLANTS IN NUDE MICE
    XINYU FU; Fiscal Year: 1991
    ..to the colon in his laboratory where histologically-intact patient-colon-cancer tissue directly onplanted in the cecum or colon metastasizes regionally and to the liver...
  32. B220+DN Tcells in Mucosal Tolerance and Inflammation
    ABDEL HAMAD; Fiscal Year: 2005
    ..similar B220+DN T cells exist in significant numbers at intraepithelial sites of the appendix, colon, cecum and in the liver, but their function has not been defined...
  33. Novel CATERPILLER gene involved in mucosal inflammation
    Beckley Davis; Fiscal Year: 2006
    ..16.1/NOD27 was shown to be upregulated ( approximately 100 fold) in the colon and cecum of ILl0-/-mice reared under SPF conditions relative to GF animals. Upregulation of 16...
  34. DIFFERENTIAL METABOLISM OF DIETARY FATTY ACIDS
    CRAIG KIEN; Fiscal Year: 2003
    ..In specific aim 4, the PI will measure the thermic effect of feeding during both the solid food and formula diet periods. The PI hypothesizes that the high OA feeding will be associated with a higher thermic effect of feeding. ..
  35. Colonic Bacterial Synthesis of Butyric Acid
    CRAIG KIEN; Fiscal Year: 2004
    ..it is hypothesized that moderate disaccharide malabsorption stimulates luminal BA synthesis in the cecum and cecal cell proliferation, but it is also hypothesized that severe disaccharide malabsorption depresses BA ..
  36. Mechanisms for differential effects of dietary fatty acids on metabolism
    CRAIG LAWRENCE KIEN; Fiscal Year: 2010
    ..important new information regarding how mitochondrial malfunction, modified by dietary FA, plays a central role in the development of obesity, the metabolic syndrome, type 2 diabetes, and both heritable and age-related metabolic diseases ..
  37. Recombinant murine IL-10 produced in situ by H. pylori
    KATHRYN EATON; Fiscal Year: 2005
    ..pylori, but will also establish a model in which the roles of other cytokines and mediators can be determined, and host and bacterial interactions can be directly evaluated in vivo. ..
  38. Host and Bacterial Factors in Disease due to H. pylori
    Kathryn A Eaton; Fiscal Year: 2010
    ..This will allow us to hire additional staff to ensure rapid completion of the remaining experiments. With these changes we fully expect to complete these experiments in 2 years. ..
  39. LETHAL OROESOPHAGEAL CANDIDIASIS: IMMUNOTHERAPY
    Edward Balish; Fiscal Year: 2004
    ..Restoration and enhancement of immune function may be critical for the effectiveness of anti-Candida vaccines that are now under development. ..
  40. INTESTINAL T-REGULATORY-1 CELLS IN MUCOSAL HOMEOSTASIS
    CHARLES ELSON; Fiscal Year: 2006
    ..Our long-term goal is an understanding of Tr1 cells sufficient to manipulate this subset as a novel therapy for human intestinal inflammatory diseases. ..
  41. CALCIUM OXALATE IN BIOLOGICAL SYSTEMS
    Marguerite Hatch; Fiscal Year: 2002
    ..abstract_text> ..
  42. Myocardial Protein Synthesis After Thermal Injury
    Charles Lang; Fiscal Year: 2005
    ..Overall, the research will elucidate the mechanisms by which myocardial protein synthesis is reduced after thermal injury, leading to the better understanding and treatment of the resulting cardiomyopathy. - ..
  43. TREATMENT OF BURN-INDUCED IMMUNOSUPPRESSION
    Edward Sherwood; Fiscal Year: 2002
    ..Administration of glucan to thermally injured mice will promote IL-12, IL-18 and IFNgamma production, increase type 1 T cell predominance and enhance resistance to infection. ..
  44. Antiretroviral-Induced Defects in Muscle Protein Synthesis
    Charles H Lang; Fiscal Year: 2010
    ..Such data is needed to both realize the full potential and avoid possible pitfalls of this drug in the long-term treatment of HIV-infected individuals. ..
  45. Mechanisms of Oxalobacter-Induced Enteric Oxalate Excretion
    Marguerite Hatch; Fiscal Year: 2010
    ..Understanding oxalate handling in PH1 and the potential roles and interactions of PAT1 and Oxalobacter in modulating the excessive body burden of oxalate in this genetic disease are now possible. ..
  46. Enteric Elimination and Degradation of Oxalic Acid
    Marguerite Hatch; Fiscal Year: 2002
    ..The potential for the clinical application of a novel treatment strategy to reduce urinary oxalate excretion is broad-based and highly significant...
  47. 8th International Primary Hyperoxaluria Workshop
    Marguerite Hatch; Fiscal Year: 2007
    ..g. pediatric and adult nephrology, transplant surgery, metabolic medicine, molecular and cell biology, clinical and molecular genetics) to discuss their common interest in Primary Hyperoxaluria. [unreadable] [unreadable] [unreadable]..
  48. BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTES
    Ellen Ebert; Fiscal Year: 2002
    ..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..
  49. Oxalate Handling in PAT1 and DRA Knockout Mice
    Marguerite Hatch; Fiscal Year: 2010
    ..Understanding oxalate handling in health and disease is essential for the development of potential pharmacological therapies. ..
  50. Prevention of Cancer by Coriolus versicolor Mushroom
    Bela Toth; Fiscal Year: 2004
    ..3: Study the preventative and therapeutic activity of PSK and VPS activity in an Apc transgenic model of intestinal polyp and adenoma formation and its association with immune augmentation. ..
  51. 11th International Congress of Mucosal Immunology
    CHARLES ELSON; Fiscal Year: 2002
    ..Support for young investigators is critical because they represent the future of the field. ..
  52. MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATION
    Charles H Lang; Fiscal Year: 2010
    ..Overall, the research design will establish the mechanism by which myocardial protein synthesis is reduced in response to alcohol abuse. ..
  53. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    James Fox; Fiscal Year: 2006
    ....
  54. Genetics of Survival of Yersinia pseudotuberculosis
    Joan Mecsas; Fiscal Year: 2002
    ..In addition, studies of yop mutant Yersinia strains in mouse strains with specific immune defects may indicate the facets of the immune system targeted by each Yop. ..
  55. Axonal Mechanical Sensitivity in Neuritis
    Geoffrey Bove; Fiscal Year: 2006
    ..These experiments promise to increase our knowledge of the mechanisms of chronic pain related to neuritis and nerve injury. [unreadable] [unreadable] [unreadable]..
  56. H. PYLORI AND IL-1Beta IN ESOPHAGEAL ONCOGENESIS
    Fritz Francois; Fiscal Year: 2008
    ..From these studies, both the microbial contribution and the host genotype contribution to adenocarcinoma risk should be able to be assessed, as well as to begin to define relevant cellular pathways. ..
  57. Neurocircuitry of Illness Induced Behavioral Depression
    LISA GOEHLER; Fiscal Year: 2009
    ....
  58. PHENOTYPIC AND PSYCHOSOCIAL STUDY OF THE L1307K MUTATION
    Henry Lynch; Fiscal Year: 2004
    ....
  59. CLOTRIMAZOLE ENEMAS FOR POUCHITIS IN CHILDREN AND ADULTS
    PAUL RUFO; Fiscal Year: 2005
    ..Abstract Not Provided ..
  60. Helicobacter hepaticus induced typhlitis
    MATTHEW MYLES; Fiscal Year: 2007
    ..abstract_text> ..