tumor stem cells

Summary

Summary: Colony-forming cells which give rise to neoplasms.

Top Publications

  1. pmc The epithelial-mesenchymal transition generates cells with properties of stem cells
    Sendurai A Mani
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 133:704-15. 2008
  2. doi Epithelial-mesenchymal transitions in development and disease
    Jean Paul Thiery
    IMCB, A STAR, Proteos, Singapore 138673, Republic of Singapore
    Cell 139:871-90. 2009
  3. ncbi Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    Shideng Bao
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 444:756-60. 2006
  4. ncbi Identification and expansion of human colon-cancer-initiating cells
    Lucia Ricci-Vitiani
    Department of Hematology and Oncology, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy
    Nature 445:111-5. 2007
  5. ncbi Identification of a cancer stem cell in human brain tumors
    Sheila K Singh
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Cancer Res 63:5821-8. 2003
  6. doi Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
    Jane E Visvader
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Nat Rev Cancer 8:755-68. 2008
  7. ncbi A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    Catherine A O'Brien
    Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario, M5G 1L7, Canada
    Nature 445:106-10. 2007
  8. ncbi Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells
    Michael F Clarke
    Stanford University School of Medicine, Stanford, California, USA
    Cancer Res 66:9339-44. 2006
  9. pmc ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    Christophe Ginestier
    Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Stem Cell 1:555-67. 2007
  10. doi Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
    Kornelia Polyak
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Cancer 9:265-73. 2009

Detail Information

Publications304 found, 100 shown here

  1. pmc The epithelial-mesenchymal transition generates cells with properties of stem cells
    Sendurai A Mani
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 133:704-15. 2008
    ..These findings illustrate a direct link between the EMT and the gain of epithelial stem cell properties...
  2. doi Epithelial-mesenchymal transitions in development and disease
    Jean Paul Thiery
    IMCB, A STAR, Proteos, Singapore 138673, Republic of Singapore
    Cell 139:871-90. 2009
    ....
  3. ncbi Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    Shideng Bao
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 444:756-60. 2006
    ..Targeting DNA damage checkpoint response in cancer stem cells may overcome this radioresistance and provide a therapeutic model for malignant brain cancers...
  4. ncbi Identification and expansion of human colon-cancer-initiating cells
    Lucia Ricci-Vitiani
    Department of Hematology and Oncology, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy
    Nature 445:111-5. 2007
    ..We conclude that colorectal cancer is created and propagated by a small number of undifferentiated tumorigenic CD133+ cells, which should therefore be the target of future therapies...
  5. ncbi Identification of a cancer stem cell in human brain tumors
    Sheila K Singh
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Cancer Res 63:5821-8. 2003
    ..The identification of a BTSC provides a powerful tool to investigate the tumorigenic process in the central nervous system and to develop therapies targeted to the BTSC...
  6. doi Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
    Jane E Visvader
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Nat Rev Cancer 8:755-68. 2008
    ..The clinical relevance of CSCs remains a fundamental issue but preliminary findings indicate that specific targeting may be possible...
  7. ncbi A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    Catherine A O'Brien
    Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario, M5G 1L7, Canada
    Nature 445:106-10. 2007
    ....
  8. ncbi Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells
    Michael F Clarke
    Stanford University School of Medicine, Stanford, California, USA
    Cancer Res 66:9339-44. 2006
  9. pmc ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    Christophe Ginestier
    Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Stem Cell 1:555-67. 2007
    ..These findings offer an important new tool for the study of normal and malignant breast stem cells and facilitate the clinical application of stem cell concepts...
  10. doi Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
    Kornelia Polyak
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Cancer 9:265-73. 2009
    ....
  11. ncbi Tumour stem cells and drug resistance
    Michael Dean
    Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    Nat Rev Cancer 5:275-84. 2005
    ..Gaining a better insight into the mechanisms of stem-cell resistance to chemotherapy might therefore lead to new therapeutic targets and better anticancer strategies...
  12. ncbi let-7 regulates self renewal and tumorigenicity of breast cancer cells
    Fengyan Yu
    Department of Breast Surgery, No 2 Affiliated Hospital, Sun Yat Sen University, Guangzhou 510120, People s Republic of China
    Cell 131:1109-23. 2007
    ..Therefore let-7 regulates multiple BT-IC stem cell-like properties by silencing more than one target...
  13. doi Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    Piyush B Gupta
    Broad Institute, Cambridge, MA 02142, USA
    Cell 146:633-44. 2011
    ..These findings contribute to our understanding of cancer heterogeneity and reveal how stochasticity in single-cell behaviors promotes phenotypic equilibrium in populations of cancer cells...
  14. pmc Efficient tumour formation by single human melanoma cells
    Elsa Quintana
    Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Nature 456:593-8. 2008
    ..Modifications to xenotransplantation assays can therefore dramatically increase the detectable frequency of tumorigenic cells, demonstrating that they are common in some human cancers...
  15. doi Identification of selective inhibitors of cancer stem cells by high-throughput screening
    Piyush B Gupta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 138:645-59. 2009
    ..This study demonstrates the ability to identify agents with specific toxicity for epithelial CSCs...
  16. ncbi Identification of pancreatic cancer stem cells
    Chenwei Li
    Department of Surgery, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Cancer Res 67:1030-7. 2007
    ....
  17. ncbi Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    Patrick C Hermann
    Department of Surgery, Ludwig Maximilians University, 81377 Munich, Germany
    Cell Stem Cell 1:313-23. 2007
    ..Strategies aimed at modulating the SDF-1/CXCR4 axis may have important clinical applications to inhibit metastasis of cancer stem cells...
  18. ncbi Prospective identification of tumorigenic prostate cancer stem cells
    Anne T Collins
    Yorkshire Cancer Research Unit, Department of Biology, University of York, York, United Kingdom
    Cancer Res 65:10946-51. 2005
    ..The identification of a prostate cancer stem cell provides a powerful tool to investigate the tumorigenic process and to develop therapies targeted to the stem cell...
  19. ncbi Identification and expansion of the tumorigenic lung cancer stem cell population
    A Eramo
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Cell Death Differ 15:504-14. 2008
    ..Molecular and functional characterization of such a tumorigenic population may provide valuable information to be exploited in the clinical setting...
  20. pmc Association of reactive oxygen species levels and radioresistance in cancer stem cells
    Maximilian Diehn
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 458:780-3. 2009
    ....
  21. pmc EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
    A Singh
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA, USA
    Oncogene 29:4741-51. 2010
    ..Finally we will discuss how EMT and CSCs may contribute to drug resistance, as well as therapeutic strategies to overcome this clinically...
  22. doi The cancer stem cell: premises, promises and challenges
    Hans Clevers
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, The Netherlands
    Nat Med 17:313-9. 2011
    ..This review attempts to summarize the underlying concepts of this notion, to distinguish hard facts from beliefs and to define the future challenges of the field...
  23. doi Cells of origin in cancer
    Jane E Visvader
    Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Nature 469:314-22. 2011
    ....
  24. doi Cancer stem cells: impact, heterogeneity, and uncertainty
    Jeffrey A Magee
    Howard Hughes Medical Institute, Children s Research Institute, and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cancer Cell 21:283-96. 2012
    ..In cancers with rapid genetic change, reversible changes in cell states, or biological variability among patients, the stem cell model may not be readily testable...
  25. pmc Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
    Aleix Prat
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, USA
    Breast Cancer Res 12:R68. 2010
    ..Here, we comprehensively characterize the recently identified claudin-low tumor subtype...
  26. doi Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
    Elgene Lim
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Nat Med 15:907-13. 2009
    ..Our findings suggest that an aberrant luminal progenitor population is a target for transformation in BRCA1-associated basal tumors ...
  27. pmc Identification and characterization of ovarian cancer-initiating cells from primary human tumors
    Shu Zhang
    Medical Sciences, Indiana University School of Medicine, Bloomington, Indiana 47405, USA
    Cancer Res 68:4311-20. 2008
    ..Based on these findings, we assert that epithelial ovarian cancers derive from a subpopulation of CD44(+)CD117(+) cells, thus representing a possible therapeutic target for this devastating disease...
  28. ncbi Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
    Rossella Galli
    Stem Cell Research Institute and Laboratory of Molecular Diagnostics, H S Raffaele, Milan, Italy
    Cancer Res 64:7011-21. 2004
    ..Thus, cells possessing all of the characteristics expected from tumor neural stem cells seem to be involved in the growth and recurrence of adult human glioblastomas multiforme...
  29. pmc Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells
    Yohei Shimono
    Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 1050 Arastradero Road, Palo Alto, CA 94304, USA
    Cell 138:592-603. 2009
    ..The coordinated downregulation of three microRNA clusters and the similar functional regulation of clonal expansion by miR-200c provide a molecular link that connects BCSCs with normal stem cells...
  30. ncbi A perivascular niche for brain tumor stem cells
    Christopher Calabrese
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Cancer Cell 11:69-82. 2007
    ..We propose that brain CSCs are maintained within vascular niches that are important targets for therapeutic approaches...
  31. pmc The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
    Can Liu
    Department of Molecular Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park, Smithville, Texas, USA
    Nat Med 17:211-5. 2011
    ..Our study shows that miR-34a is a key negative regulator of CD44(+) prostate cancer cells and establishes a strong rationale for developing miR-34a as a novel therapeutic agent against prostate CSCs...
  32. doi Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
    Louis Vermeulen
    Laboratory for Experimental Oncology and Radiobiology LEXOR, Center for Experimental Molecular Medicine CEMM, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Nat Cell Biol 12:468-76. 2010
    ..We therefore propose that stemness of colon cancer cells is in part orchestrated by the microenvironment and is a much more dynamic quality than previously expected that can be defined by high Wnt activity...
  33. pmc Identification of cells initiating human melanomas
    Tobias Schatton
    Transplantation Research Center, Children s Hospital Boston and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 451:345-9. 2008
    ..Identification of tumour-initiating cells with enhanced abundance in more advanced disease but susceptibility to specific targeting through a defining chemoresistance determinant has important implications for cancer therapy...
  34. pmc A restricted cell population propagates glioblastoma growth after chemotherapy
    Jian Chen
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
    Nature 488:522-6. 2012
    ....
  35. doi Heterogeneity in cancer: cancer stem cells versus clonal evolution
    Mark Shackleton
    Howard Hughes Medical Institute, Life Sciences Institute, Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 138:822-9. 2009
    ....
  36. ncbi Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells
    Maria M Ho
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Cancer Res 67:4827-33. 2007
    ..These findings indicate that SP is an enriched source of lung tumor-initiating cells with stem cell properties and may be an important target for effective therapy and a useful tool to investigate the tumorigenic process...
  37. pmc miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells
    Joachim Silber
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
    BMC Med 6:14. 2008
    ..In this study, we investigated the role of microRNAs in regulating the differentiation and proliferation of neural stem cells and glioblastoma-multiforme tumor cells...
  38. ncbi The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation
    Tiffany M Phillips
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095 1714, USA
    J Natl Cancer Inst 98:1777-85. 2006
    ..Cancer-initiating cells can now be prospectively isolated from breast cancer cell lines and tumor samples and propagated as mammospheres in vitro under serum-free conditions...
  39. pmc A distinct "side population" of cells with high drug efflux capacity in human tumor cells
    C Hirschmann-Jax
    Center for Cell and Gene Therapy, Baylor College of Medicine, Methodist Hospital and Texas Children s Hospital, and DeBakey Department of Surgery, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:14228-33. 2004
    ....
  40. doi Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens
    Steven M Pollard
    Wellcome Trust Centre for Stem Cell Research and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Cell Stem Cell 4:568-80. 2009
    ..A proof-of-principle live cell imaging-based chemical screen (450 FDA-approved drugs) identifies both differential sensitivities of GNS cells and a common susceptibility to perturbation of serotonin signaling...
  41. pmc A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth
    Alexander Roesch
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Cell 141:583-94. 2010
    ..These results suggest a new understanding of melanoma heterogeneity with tumor maintenance as a dynamic process mediated by a temporarily distinct subpopulation...
  42. pmc Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
    Zhizhong Li
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 15:501-13. 2009
    ..Our results demonstrate that GSCs differentially respond to hypoxia with distinct HIF induction patterns, and HIF2alpha might represent a promising target for antiglioblastoma therapies...
  43. pmc Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment
    Giulia Bertolini
    Molecular Cytogenetics Unit, Department of Experimental Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, 20133 Milan, Italy
    Proc Natl Acad Sci U S A 106:16281-6. 2009
    ..The molecular features of these cells may provide the rationale for more specific therapeutic targeting and the definition of predictive factors in clinical management of this lethal disease...
  44. doi Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas
    Arnout G Schepers
    Hubrecht Institute, Koninklijke Nederlandse Akademie van Wetenschappen, and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands
    Science 337:730-5. 2012
    ..The Lgr5(+) cells are intermingled with Paneth cells near the adenoma base, a pattern reminiscent of the architecture of the normal crypt niche...
  45. doi CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?
    Margot Zoller
    Department of Tumour Cell Biology, University Hospital of Surgery and German Cancer Research Centre, D69120 Heidelberg, Germany
    Nat Rev Cancer 11:254-67. 2011
    ..expression of the molecule or is CD44 expression advantageous as it fulfils some of the special properties that are displayed by CICs, such as self-renewal, niche preparation, epithelial-mesenchymal transition and resistance to apoptosis?..
  46. doi Crypt stem cells as the cells-of-origin of intestinal cancer
    Nick Barker
    Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht and University Medical Centre Utrecht, Netherlands
    Nature 457:608-11. 2009
    ..Even after 30weeks, large adenomas are very rare in these mice. We conclude that stem-cell-specific loss of Apc results in progressively growing neoplasia...
  47. doi Critical appraisal of the side population assay in stem cell and cancer stem cell research
    Anna Golebiewska
    Norlux Neuro Oncology Laboratory, Oncology Department, Centre de Recherche Public de la Santé, 84 Val Fleuri, Luxembourg
    Cell Stem Cell 8:136-47. 2011
    ..To improve the consistency and reliability of data between laboratories, we propose a set of recommendations for SP assay data reporting...
  48. doi Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways
    Naoko Takebe
    National Cancer Institute, Division of Cancer Treatment and Diagnosis, Cancer Therapy Evaluation Program, Investigational Drug Branch, EPN7131, 6130 Executive Boulevard, Rockville, Bethesda, MD 20852, USA
    Nat Rev Clin Oncol 8:97-106. 2011
    ..The role that embryonic signaling pathways play in the function of CSCs, the development of new anti-CSC therapeutic agents, and the complexity of potential CSC signaling cross-talk are described in this Review...
  49. doi Defining the mode of tumour growth by clonal analysis
    Gregory Driessens
    Universite Libre de Bruxelles, IRIBHM, Brussels B 1070, Belgium
    Nature 488:527-30. 2012
    ..This study presents the first experimental evidence for the existence of CSCs during unperturbed solid tumour growth...
  50. doi Interactions between cancer stem cells and their niche govern metastatic colonization
    Ilaria Malanchi
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research Molecular Oncology, 1015 Lausanne, Switzerland
    Nature 481:85-9. 2012
    ..We suggest that the education of stromal cells by infiltrating tumour cells is an important step in metastatic colonization and that preventing de novo niche formation may be a novel strategy for the treatment of metastatic disease...
  51. pmc Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance
    Ayesha B Alvero
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Cell Cycle 8:158-66. 2009
    ..The identification and cloning of human OCSCs can aid in the development of better therapeutic approaches for ovarian cancer patients...
  52. doi Stem cell gene expression programs influence clinical outcome in human leukemia
    Kolja Eppert
    Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research, Ontario Cancer Institute, University Health Network and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Nat Med 17:1086-93. 2011
    ..Thus, determinants of stemness influence the clinical outcome of AML, establishing that LSCs are clinically relevant and not artifacts of xenotransplantation...
  53. pmc Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
    Heather A Hirsch
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02115, USA
    Cancer Res 69:7507-11. 2009
    ....
  54. pmc Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
    Christine L Chaffer
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 108:7950-5. 2011
    ..The observed plasticity may allow derivation of patient-specific adult stem cells without genetic manipulation and holds important implications for therapeutic strategies to eradicate cancer...
  55. doi A hierarchy of self-renewing tumor-initiating cell types in glioblastoma
    Ruihuan Chen
    Department of Tumor Biology and Angiogenesis, Genentech Inc, San Francisco, CA 94080, USA
    Cancer Cell 17:362-75. 2010
    ....
  56. doi Stem cell concepts renew cancer research
    John E Dick
    Division of Cell and Molecular Biology, University Health Network, and Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
    Blood 112:4793-807. 2008
    ..This review provides a historical overview of the influence of hematology on the development of stem cell concepts and their linkage to cancer...
  57. pmc Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271
    Alexander D Boiko
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94304 5542, USA
    Nature 466:133-7. 2010
    ....
  58. doi The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells
    Angelo Cicalese
    Istituto Europeo di Oncologia IEO, Department of Experimental Oncology at the IFOM IEO Campus, Milan, Italy
    Cell 138:1083-95. 2009
    ..These data demonstrate that p53 regulates polarity of cell division in mammary SCs and suggest that loss of p53 favors symmetric divisions of cancer SCs, contributing to tumor growth...
  59. ncbi Cancer stem cells: models and concepts
    Piero Dalerba
    Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94304, USA
    Annu Rev Med 58:267-84. 2007
    ..This model, first developed in human myeloid leukemias, is today being extended to solid tumors, such as breast and brain cancer. We review the biological basis and the therapeutic implications of the stem cell model of cancer...
  60. pmc PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
    Anne Marie Bleau
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cell Stem Cell 4:226-35. 2009
    ..This Akt-induced ABCG2 activation results from its transport to the plasma membrane. Temozolomide, the standard treatment of gliomas, although not an ABCG2 substrate, increases the SP in glioma cells, especially in cells missing PTEN...
  61. doi Targeting breast cancer stem cells
    Suling Liu
    Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA
    J Clin Oncol 28:4006-12. 2010
    ..The effective targeting of breast cancer stem cells has the potential to significantly improve outcome for women with both early-stage and advanced breast cancer...
  62. doi Significance of CD90+ cancer stem cells in human liver cancer
    Zhen Fan Yang
    Center for Cancer Research and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Cancer Cell 13:153-66. 2008
    ..Differential gene expression profiles were identified in the CD45(-)CD90+ and CD45(-)CD90(-) cells isolated from tissue and blood samples from liver cancer patients and controls...
  63. pmc Aldehyde dehydrogenase 1-positive cancer stem cells mediate metastasis and poor clinical outcome in inflammatory breast cancer
    Emmanuelle Charafe-Jauffret
    Department of Molecular Oncology, Institut Paoli Calmettes UMR891 Institut National de la Sante et de la Recherche Medicale, Universite de la Mediterranee, Marseille Cancer Research Center, Marseille, France
    Clin Cancer Res 16:45-55. 2010
    ..To examine the role of cancer stem cells (CSC) in mediating metastasis in inflammatory breast cancer (IBC) and the association of these cells with patient outcome in this aggressive type of breast cancer...
  64. ncbi Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    Omer H Yilmaz
    Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Nature 441:475-82. 2006
    ..Mechanistic differences between normal stem cells and cancer stem cells can thus be targeted to deplete cancer stem cells without damaging normal stem cells...
  65. ncbi Cancer as an evolutionary and ecological process
    Lauren M F Merlo
    Cellular and Molecular Oncology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Cancer 6:924-35. 2006
    ..The tools of evolutionary biology and ecology are providing new insights into neoplastic progression and the clinical control of cancer...
  66. doi Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation
    Shih Hwa Chiou
    Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan
    Cancer Res 70:10433-44. 2010
    ..Our results support the notion that the Oct4/Nanog signaling controls epithelial-mesenchymal transdifferentiation, regulates tumor-initiating ability, and promotes metastasis of LAC...
  67. doi The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells
    Michelangelo Cordenonsi
    Department of Histology, Microbiology, and Medical Biotechnologies, University of Padua School of Medicine, viale Colombo 3, 35126 Padua, Italy
    Cell 147:759-72. 2011
    ..This study links the CSC concept to the Hippo pathway in breast cancer and reveals a mechanistic basis of the control of Hippo kinases by cell polarity...
  68. pmc Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells
    Yu Chih Chen
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 3:e2637. 2008
    ..Future research is warranted regarding the up-regulated expression of Oct-4 in LC-CD133(+) and malignant lung cancer...
  69. doi Cancer stem cell niche: the place to be
    Tijana Borovski
    Laboratory for Experimental Oncology and Radiobiology, Center for Experimental Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cancer Res 71:634-9. 2011
    ..Combined with its role in the protection of CSCs against genotoxic insults, these data strongly put forward the niche as an important target for novel therapies...
  70. ncbi Asymmetric and symmetric stem-cell divisions in development and cancer
    Sean J Morrison
    Howard Hughes Medical Institute and Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Nature 441:1068-74. 2006
    ..The facultative use of symmetric or asymmetric divisions by stem cells may be a key adaptation that is crucial for adult regenerative capacity...
  71. doi Cancer stem cells: problems for therapy?
    Malcolm R Alison
    Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    J Pathol 223:147-61. 2011
    ....
  72. ncbi Drug discovery approaches to target Wnt signaling in cancer stem cells
    Joshua C Curtin
    Oncology Drug Discovery, Research and Development, Bristol Myers Squibb, Princeton, NJ, USA
    Oncotarget 1:552-66. 2010
    ..This review will focus on the clinical relevance of the Wnt pathway in CSCs and tumor cell biology, as well as points of therapeutic intervention and recent advances in targeting Wnt/β-catenin signaling...
  73. doi TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
    Kazuhito Naka
    Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920 0934, Japan
    Nature 463:676-80. 2010
    ..Our results demonstrate a critical role for the TGF-beta-FOXO pathway in the maintenance of LICs, and strengthen our understanding of the mechanisms that specifically maintain CML LICs in vivo...
  74. pmc The increasing complexity of the cancer stem cell paradigm
    Jeffrey M Rosen
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 324:1670-3. 2009
    ....
  75. pmc Hypoxia-inducible factors, stem cells, and cancer
    Brian Keith
    Abramson Family Cancer Research Institute, University of Pennsylvania, 453 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Cell 129:465-72. 2007
    ..As many cancers are thought to develop from a small number of transformed, self-renewing, and multipotent "cancer stem cells," these results suggest new roles for HIFs in tumor progression...
  76. pmc The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype
    John M Heddleston
    Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, OH, USA
    Cell Cycle 8:3274-84. 2009
    ....
  77. doi Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content
    Salvatore Pece
    IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy
    Cell 140:62-73. 2010
    ..Our data support the notion that the heterogeneous phenotypical and molecular traits of human breast cancers are a function of their CSC content...
  78. ncbi A tumorigenic subpopulation with stem cell properties in melanomas
    Dong Fang
    Program of Molecular and Cellular Oncogenesis, The Wistar Institute and Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, PA 19104, USA
    Cancer Res 65:9328-37. 2005
    ..Based on these findings, we propose that melanomas can contain a subpopulation of stem cells that contribute to heterogeneity and tumorigenesis. Targeting this population may lead to effective treatments for melanomas...
  79. ncbi The biology of cancer stem cells
    Neethan A Lobo
    Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109, USA
    Annu Rev Cell Dev Biol 23:675-99. 2007
    ..Understanding the biology of cancer stem cells will contribute to the identification of molecular targets important for future therapies...
  80. ncbi Cancer stem cells: an old idea--a paradigm shift
    Max S Wicha
    University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109 0942, USA
    Cancer Res 66:1883-90; discussion 1895-6. 2006
    ..The development of more effective cancer therapies may thus require targeting this important cell population...
  81. pmc Module map of stem cell genes guides creation of epithelial cancer stem cells
    David J Wong
    Program in Epithelial Biology, Stanford University, Stanford, CA 94305, USA
    Cell Stem Cell 2:333-44. 2008
    ..Thus, activation of an ESC-like transcriptional program in differentiated adult cells may induce pathologic self-renewal characteristic of cancer stem cells...
  82. pmc Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells
    Dejuan Kong
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America
    PLoS ONE 5:e12445. 2010
    ..Increasing evidence suggests that EMT-type cells share many biological characteristics with cancer stem-like cells...
  83. ncbi Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0946, USA
    Cancer Res 66:6063-71. 2006
    ..These studies support a cancer stem cell model in which the hedgehog pathway and Bmi-1 play important roles in regulating self-renewal of normal and tumorigenic human mammary stem cells...
  84. pmc CD44+ CD24(-) prostate cells are early cancer progenitor/stem cells that provide a model for patients with poor prognosis
    E M Hurt
    Cancer Stem Cell Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Br J Cancer 98:756-65. 2008
    ....
  85. pmc Targeting Notch to target cancer stem cells
    Antonio Pannuti
    University of Mississippi Cancer Institute, Jackson, MS 39216, USA
    Clin Cancer Res 16:3141-52. 2010
    ..This article summarizes the most recent developments in the field of Notch-targeted cancer therapeutics, with emphasis on CSC...
  86. pmc Identification of gastric cancer stem cells using the cell surface marker CD44
    Shigeo Takaishi
    Division of Digestive and Liver Disease, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Stem Cells 27:1006-20. 2009
    ..These results support the existence of gastric CSCs and may provide novel approaches to the diagnosis and treatment of gastric cancer...
  87. pmc A luminal epithelial stem cell that is a cell of origin for prostate cancer
    Xi Wang
    Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nature 461:495-500. 2009
    ..These observations indicate that CARNs represent a new luminal stem cell population that is an efficient target for oncogenic transformation in prostate cancer...
  88. pmc Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
    Chen Zhao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 458:776-9. 2009
    ....
  89. pmc Selective targeting of radiation-resistant tumor-initiating cells
    Mei Zhang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030 3498, USA
    Proc Natl Acad Sci U S A 107:3522-7. 2010
    ..Thus, these results suggest that pretreatment with Akt inhibitors before ionizing radiation treatment may be of potential therapeutic benefit to patients...
  90. pmc The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations
    Anna Dubrovska
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:268-73. 2009
    ....
  91. doi SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity
    Rosaria Maria Rita Gangemi
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Stem Cells 27:40-8. 2009
    ..SOX2, or its immediate downstream effectors, would then be an ideal target for glioblastoma therapy...
  92. doi Tumour-initiating cells: challenges and opportunities for anticancer drug discovery
    Bin Bing S Zhou
    Oncology Discovery, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA
    Nat Rev Drug Discov 8:806-23. 2009
    ..This Review considers recent advances in the cancer stem cell field, focusing on the challenges and opportunities for anticancer drug discovery...
  93. pmc Integrin alpha 6 regulates glioblastoma stem cells
    Justin D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell Stem Cell 6:421-32. 2010
    ..Our results provide evidence that GSCs express high levels of integrin alpha6, which can serve not only as an enrichment marker but also as a promising antiglioblastoma therapy...
  94. doi CD133+ glioblastoma stem-like cells are radiosensitive with a defective DNA damage response compared with established cell lines
    Amy M McCord
    Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida 33612, USA
    Clin Cancer Res 15:5145-53. 2009
    ..Therefore, to better understand the radioresponse of this cancer stem cell, we have used established cell lines as a framework for defining their in vitro radioresponse...
  95. pmc Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer
    Feng Jiang
    Department of Pathology, Greenbaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201 1192, USA
    Mol Cancer Res 7:330-8. 2009
    ..These findings offer an important new tool for the study of lung CSCs and provide a potential prognostic factor and therapeutic target for treatment of the patients with lung cancer...
  96. pmc p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
    Hongwu Zheng
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 455:1129-33. 2008
    ....
  97. ncbi Identification of putative stem cell markers, CD133 and CXCR4, in hTERT-immortalized primary nonmalignant and malignant tumor-derived human prostate epithelial cell lines and in prostate cancer specimens
    Jun Miki
    Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Cancer Res 67:3153-61. 2007
    ..Expression of CXCR4 was also detected in CD133(+) cancer cells. These novel in vitro models may offer useful tools for the study of the biological features and functional integration of normal and cancer stem cells in prostate...
  98. ncbi CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway
    S Ma
    Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Oncogene 27:1749-58. 2008
    ..Targeting of this specific survival signaling pathway in CD133+ HCC CSCs may provide a novel therapeutic model for the disease...
  99. pmc Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition
    Sharmila Shankar
    Department of Pathology and Laboratory Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 6:e16530. 2011
    ..The objectives of this study were to examine the molecular mechanisms by which resveratrol inhibits stem cell characteristics of pancreatic CSCs derived from human primary tumors and Kras(G12D) transgenic mice...
  100. ncbi Cancer stem-like cells in human prostate carcinoma cells DU145: the seeds of the cell line?
    Chen Wei
    Department of Urology, Zhongshan Hospital of Fudan University, Shanghai, PR China
    Cancer Biol Ther 6:763-8. 2007
    ..CD133+ cells differed significantly from CD44+ integrinalpha(2)beta(1)(-/low)CD133- cells and the total population in clone generation, genes expression, differentiation, proliferative and tumorigenic potential...
  101. doi EZH2 is essential for glioblastoma cancer stem cell maintenance
    Mario Luca Suva
    Division of Experimental Pathology, Institute of Pathology, University of Lausanne, Lausanne, Switzerland
    Cancer Res 69:9211-8. 2009
    ....

Research Grants66

  1. Analysis of alphaVbeta8 Integrin In Gliomagenesis
    Joseph H McCarty; Fiscal Year: 2012
    ..intracranial tumors with vascular abnormalities similar to those found in high-grade gliomas;and (iv) tumor stem cells primarily contribute to vascular pathologies in gliomas, and av[unreadable]8 integrin expression defines sub-..
  2. Comprehensive Phenotypic Comparison of Normal and Cancer Stem Cells
    RAMESH A contact SHIVDASANI; Fiscal Year: 2010
    ..to the goals of the "Grand Opportunities" funding mechanism, and indeed, in-depth comparison of normal and tumor stem cells can only be accomplished under the aegis of such a program...
  3. Epigenetic Regulation of Medulloblastoma
    LAURIE L JACKSON-GRUSBY; Fiscal Year: 2012
    ..important functional role in cancer stem cells encourages us to test the importance of this pathway in brain tumor stem cells derived from medulloblastoma...
  4. Role of Olig Genes in Human Gliomagenesis
    Santosh Kesari; Fiscal Year: 2011
    A small population of CD133 (a stem cell marker) positive "tumor stem cells" has been recently shown to embody the tumorigenic phenotype of human glioblastomas...
  5. Elimination of Carcinogen-Induced Tumor Stem Cells by ATF5 Loss of Function.
    JAMES ANGELASTRO; Fiscal Year: 2009
    ..brain neoplasm, arising from environmental carcinogens, promotes transformations of neural stem cells to tumor stem cells that in turn support the growth of tumors...
  6. Interplay between intrinsic and extrinsic force and glioma aggression
    Matt Barnes; Fiscal Year: 2013
    ..The recent discovery of a vascular niche that not only harbors tumor stem cells but also provides essential signals for self-renewal and maintenance provides evidence that tumor cell ..
  7. RNA-based Immunotherapy Targeting Antigens Unique to Brain Tumor Stem Cells
    John H Sampson; Fiscal Year: 2012
    ..These brain tumor stem cells (BTSC) can be segregated by the neural stem cell marker, CD133, and are widely believed to be the cells ..
  8. The Role of the Stem Cell Niche in ALL
    Laura F Gibson; Fiscal Year: 2013
    The contribution of tumor stem cells to progression and relapse of cancer is recognized as a significant clinical challenge in both solid and hematologic malignancies...
  9. Optimizing Induction Conditions for Immunotherapeutic CTL
    Boris Minev; Fiscal Year: 2013
    ..CTL in the GL261 mouse glioma model, where the tumor cell inoculum either is or is not enriched for brain tumor stem cells (BTSC). The latter goal will allow for a determination of BTSC immunosensitivity/immunoresistance...
  10. Mouse Model of Age-Associated Monoclonal Gammopathy
    Peter Leif Bergsagel; Fiscal Year: 2013
    ..concerning the susceptibility to one of the commonest age- associated pre-malignant conditions, the nature of tumor stem cells, and the genetics of multi-step tumor progression...
  11. Human Breast Cancer Stem Cell Surrogates
    Wendy A Woodward; Fiscal Year: 2012
    ..cell features and correlate these to outcome and ALDH1 staining in the primary;2) Measure CTCs and primary tumor stem cells in patients receiving neoadjuvant chemotherapy and correlate response to therapy between these measures as ..
  12. DNA Methylation and Ovarian Cancer
    Kenneth P Nephew; Fiscal Year: 2012
    ..that the inadequacy of standard ovarian cancer therapies is largely due to their failure to target ovarian tumor stem cells (resulting in inevitable relapse)...
  13. Epigenomic Mapping in Human Tumor Stem Cells
    Richard A Young; Fiscal Year: 2013
    ..For insight on tumor stem cells, we will take advantage of a previously developed model system that provides a consistent source of cells ..
  14. Mouse models of age-associated monoclonal gammopathy
    PETER BERGSAGEL; Fiscal Year: 2009
    ..concerning the susceptibility to one of the commonest age-associated pre-malignant conditions, the nature of tumor stem cells, and the genetics of multi-step tumor progression...
  15. Re-setting the Endothelial Ceramide Rheostat
    Richard N Kolesnick; Fiscal Year: 2013
    ..deprivation (measured by EPR oximetry), and that this vascular dysfunction represses DNA damage repair in tumor stem cells to enhance cure by SDRT...
  16. Cellular Quiescence and Brain Tumor Stem Cells
    Cho Lea Tso; Fiscal Year: 2009
    DESCRIPTION (Provided by the applicant) Abstract: The discovery of tumor stem cells in human brain tumors has greatly changed the biological and clinical views of treatment-refractory brain cancer...
  17. Generation of tumor stem cell lines for directed therapeutics of brain cancer
    Elva Diaz; Fiscal Year: 2009
    ..An increasing amount of evidence suggests that only a few atypical cells (brain tumor stem cells) within the cancerous mass are responsible for the initiation, growth and recurrence of primary brain tumors...
  18. DNA MISMATCH REPAIR AND CANCER IN MURINE MODELS
    Winfried Edelmann; Fiscal Year: 2013
    ..Finally, we propose to determine the importance of MMR in intestinal tumor stem cells for the sensitivity or resistance of intestinal tumors to chemotherapeutic treatment.
  19. Characterizing the glioma cell of origin in vivo using MADM, a mouse genetic mosa
    Hui Zong; Fiscal Year: 2013
    ..Recently, it was reported that gliomas contain a population of tumor stem cells that can form self renewable tumor spheres in culture and re- initiate gliomas after transplantation into ..
  20. The role of CD44 in glioma biology in a novel murine model.
    STACY ANN DECKER; Fiscal Year: 2011
    ..My central hypothesis is that brain tumor stem cells utilize CD44 to promote invasion, self-renewal and tumor recurrence...
  21. Investigating Alpha-secretase inhibitors as Notch inhibitors &anti-glioma agents
    Benjamin W Purow; Fiscal Year: 2012
    ..from us and others indicates that gliomas and other cancers harbor a small therapy-resistant subpopulation of tumor stem cells responsible for tumorigenesis...
  22. Mixed-Ligand Targeting of a Nano-Pharmaceutical Against GBM Stem Cells
    Steven L Armentrout; Fiscal Year: 2012
    ..PNL) will produce a novel, nano- pharmaceutical compound that preferentially selects and destroys brain tumor stem cells (BTSCs) to aid the treatment of glioblastoma multiforme (GBM), one of the most lethal brain cancers...
  23. The Ureb-1 ubiquitin ligase in neural stem cells and cancer
    Anna Lasorella; Fiscal Year: 2012
    ..of cells within brain tumors displays stem-like features and retains tumor-initiating capacity (brain tumor stem cells, BTSC)...
  24. Proliferative control of normal & oncogenically transformed stem cells in vivo
    Norbert Perrimon; Fiscal Year: 2010
    ..expected to advance our understanding of (1) the factors that determine the proliferation rate of normal and tumor stem cells, including whether tumors can create their own microenvironment to bring about self-sufficiency in ..
  25. Determining the Progenitor-Like Capacity of Liver Cancer Cells in vivo.
    NICOLE K PAULK; Fiscal Year: 2011
    ..In an attempt to alleviate this, I will also determine the affects of the aging process on tumor stem cells in mice hepatocarcinomas. Aim 1: Determine if intrahepatic cell fusion events induce liver tumor formation. a...
  26. Role of NKCC1 on Brain Tumor Stem Cell Migration After EGF and Slit-2 Stimulation
    Alfredo Quinones-Hinojosa; Fiscal Year: 2013
    ..Our project aims to study the migration of GBM-derived Brain Tumor Stem Cells (BTSCs)...
  27. Tumor repressive role of Ets2 in the intestine
    ROBERT GLEN OSHIMA; Fiscal Year: 2012
    ..We propose to determine if Ets2 restricts intestinal stem cells and tumor stem cells by inactivating Ets2 genetically and over expressing Ets2 in mice...
  28. Tracking the in vivo proliferative history of human glioma-derived stem cells
    HONGYAN JENNY ZOU; Fiscal Year: 2013
    ..Subsequent stem cell cultures will then select tumor stem cells from these two groups for further studies...
  29. TGF-Beta, Neural Stem Cella and Gliomagenesis
    TY WILLIAM ABEL; Fiscal Year: 2012
    ..of the transforming growth factor-beta (TGF-beta) superfamily regulate thetumorigenic properties of brain tumor stem cells, and TGF-beta has been implicated in the pathogenesis and progression of human gliomas...
  30. STRATEGIES TO ENHANCE VIROTHERAPY FOR BREAST CANCER
    Xiaoliu Zhang; Fiscal Year: 2012
    ..Aim 3 will seek to develop strategies that enable Synco-2D to destroy tumor stem cells for a long-lasting therapeutic effect...
  31. Nuance Spectra System
    Robert J Distel; Fiscal Year: 2010
    ..Charles Stiles PhD has found a pathway that makes the rare populations of brain tumor stem cells resistant to genotoxic agents...
  32. Bone Morphogentic Protein signaling in the control of skin development, hair grow
    Vladimir A Botchkarev; Fiscal Year: 2013
    ....
  33. Bone Morphogentic Protein signaling in the control of skin development, hair grow
    Vladimir Botchkarev; Fiscal Year: 2009
    ..abstract_text> ..
  34. Stem Cells, Progenitors, and the Origin of Medulloblastoma
    Robert J Wechsler-Reya; Fiscal Year: 2013
    ..Identifying these cells may allow us to develop more effective methods for eradicating the tumor. ..
  35. Selective Differentiation of Glioblastoma Stem Cells
    SAMUEL DAVID RABKIN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Tumor stem cells are a subpopulation of cells isolated from tumors, including glioblastoma, that have stem-like properties and the ability to efficiently initiate tumor formation...
  36. EGFR signaling and normal and tumor-derived neural stem cell behavior
    John A Boockvar; Fiscal Year: 2012
    ..These tumor stem cells (TSCs) maintain the aggressive phenotype of GBM due to their enhanced proliferation, motility, invasion and ..
  37. Program on Molecular and Cellular Mechanisms of Tumorigenesis
    Jef D Boeke; Fiscal Year: 2010
    ..role of telomerase in normal growth and tumorigenesis, and the relationship between tissue stem cells and "tumor stem cells"...
  38. Dynamics of Tumor Stem Cells in Cancer Initiation, Therapy, and Resistance
    Franziska Michor; Fiscal Year: 2012
    ..The research program outlined in this proposal will establish a quantitative understanding of tumor stem cells in cancer initiation, progression, treatment, and resistance and will provide theoretical frameworks ..
  39. RNAi screen of the glioblastoma stem cell kinome under hypoxia and normoxia
    Brent H Cochran; Fiscal Year: 2013
    ..It has recently been possible to isolate and maintain continuously in culture these putative tumor stem cells. These cells grow as neurospheres and retain the ability to differentiate into neurons and astrocytes despite ..
  40. Suppression of Glioblastoma Stem Cells by Kruppel-Like Factor 9
    John J Laterra; Fiscal Year: 2013
    ....
  41. Regulation of Breast Stem Cells by the Microenvironment
    Max S Wicha; Fiscal Year: 2013
    ..We propose to develop a strategy aimed at interfering with interactions between tumor stem cells and other cells in the tumor microenvironment which comprise the stem cell "niche"...
  42. IMMUNOTOXINS IN BONE MARROW TRANSPLANTATION
    Daniel A Vallera; Fiscal Year: 2013
    ..In aim 2, we propose to study this new strategy of targeting tumor stem cells. Aim 1 relates to Aim 2 since the deimmunization strategies are used to construct anti-stem cell targeted ..
  43. Inhibition of Brain Tumor Stem Cell Tumorigenicity using Self-assembling Nanogels
    Maya Srikanth; Fiscal Year: 2012
    ..Such relapse may be due to the persistence of brain tumor stem cells (BTSCs), a small subset of glioma cells with stem-like characteristics that have recently been proposed to ..
  44. Targeting Brain Tumor Stem Cells Through Novel Therapeutic Combinations
    Jeremy N Rich; Fiscal Year: 2013
    ..We have previously demonstrated that brain tumor stem cells are resistant to radiation and also promote tumor angiogenesis...
  45. Mechanisms of Carcinoma Differentiation and Invasion
    Arthur M Mercurio; Fiscal Year: 2013
    ..repressor that functions as an oncoprotein and has been implicated in the self-renewal of prostate tumor stem cells. A key issue that arises from these findings is how loss of ER? contributes to Bmi-1 expression and the ..
  46. Targeting Brain Tumor Stem Cells
    CHRISTINE ELISSA EYLER; Fiscal Year: 2010
    ..We expect this approach may generate new and effective treatment strategies for the tens of thousands of patients diagnosed with malignant brain tumors every year. ..
  47. VEGF Signaling in Mammary Tumorigenesis
    Arthur M Mercurio; Fiscal Year: 2013
    ..to the regulation of Bmi-1, a polycomb group transcriptional repressor important for the function of tumor stem cells, by a FAK- dependent mechanism...
  48. Cancer Stem Cells and Radiotherapy: New Approaches to Radiosensitization
    BEVERLY SHRIVER MITCHELL; Fiscal Year: 2010
    ..These tumor-initiating or tumor stem cells have properties that differ from those in the bulk of the tumor...
  49. CELLULAR EFFECTS OF INHIBITION OF THYMIDYLATE SYNTHASE
    RICHARD MORAN; Fiscal Year: 1993
    ..Finally, an explanation for the limited increase in the host toxicity of 5-FU when folinic acid is simultaneously administered will be sought on a biochemical level...
  50. Isolation and Characterization of Tumor Stem Cells from Melanoma Patients
    Alexander D Boiko; Fiscal Year: 2013
    ..b>Tumor stem cells (TSCs) in other cancers were shown to be resistant to most conventional chemo and radio therapies, to have ..
  51. Identification of cancer stem cell therapeutic targets
    Michael Clarke; Fiscal Year: 2013
    This program project grant is in response to RFA-CA-08-020 entitled "Tumor Stem Cells in Cancer Biology, Prevention, and Therapy"...
  52. Isolation and Characterization of Tumor Stem Cells from Melanoma Patients
    Alexander D Boiko; Fiscal Year: 2012
    ..b>Tumor stem cells (TSCs) in other cancers were shown to be resistant to most conventional chemo and radio therapies, to have ..
  53. TAS::75 0849::TAS
    Paul West; Fiscal Year: 2010
    Brain tumor stem cells (BTSCs) are a subset population within tumors that are widely believed to be responsible for tumor recurrence, due to their ability to self-renew, differentiate, migrate, and initiate tumor propagation...
  54. Brain Tumor Stem Cell-targeted Gene Therapy
    JOHN OHLFEST; Fiscal Year: 2007
    ..a heterogeneous tumor comprised of differentiated tumor cells and cancerous progenitor cells known as "brain tumor stem cells" (BTSCs)...
  55. Cancer Stem Cell Niche in Brain Tumors
    Xing Fan; Fiscal Year: 2013
    ..Answering these questions will facilitate the development of novel therapies and enhance our understanding of cancer stem cell biology. ..
  56. PI3K-mTOR signaling in stem cells, tissue homeostasis, and cancer
    David A Guertin; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Techniques to purify and study normal and tumor stem cells are rapidly improving, yet we still understand relatively little about the signaling pathways that balance stem cell proliferation and self-..
  57. Characterization of CD44 in brain tumor stem cells
    Ichiro Nakano; Fiscal Year: 2010
    ..brain tumors, recent investigations, including our own, have identified a stem cell population, called `brain tumor stem cells (BTSC)'...
  58. NON-GENETIC CELL HETEROGENEITY IN TUMOR EVOLUTION
    Sui Huang; Fiscal Year: 2007
    ..and cancer, but also could help optimize scheduling of chemotherapy so as to suppress selection of resistance and better target tumor stem cells. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]
  59. Mammary Tumor Stem Cells
    Anne Peaston; Fiscal Year: 2009
    ..Waptag 1 is an attractive model in which to test the potential of fluorescently marked PI-MECs as mammary tumor stem cells. To test the hypothesis that mammary tumors in Waptag 1 arise from PI-MEC cells, this project will develop ..
  60. ABCB5 P-Glycoprotein in Cancer Multidrug Resistance
    Markus H Frank; Fiscal Year: 2010
    ..function as a drug efflux transporter, and regulating tumor renewal as a determinant of cell fusion involving tumor stem cells. This study aims to (1) identify systematically ABCB5 drug efflux substrates and examine the role of ABCB5 in ..
  61. The Role of Sphingosine Kinase in Glioblastoma Stem Cells
    James Van Brocklyn; Fiscal Year: 2009
    ..indicate that glioblastoma multiforme (GBM) tumors contain a subpopulation of stem-like cells called "brain tumor stem cells" (BTSC) which are capable of self-renewal and of reforming a tumor with similar histological characteristics ..
  62. GENE CONTROL OF MAMMALIAN DEVELOPMENT AND DISEASE
    Beatrice Mintz; Fiscal Year: 1990
    ..These genes are especially active in early embryo stem cells, primordial germ cells, and early tumor stem cells and may be a prerequisite for stem cell maintenance...
  63. Identification of ligand signaling for the stem cell marker LGR5
    Aaron Hsueh; Fiscal Year: 2009
    ..LGR5 was found to be a marker for adult and tumor stem cells of gastrointestinal, mammary gland, hair follicle, gonadal and other origins...
  64. MINIMAL RESIDUAL TUMOR IN SMALL CELL LUNG CANCER
    Ravi Salgia; Fiscal Year: 2001
    ..many of our systemic agents eradicate the same tumor subpopulation, but fail to abolish a central core of tumor stem cells, presumably enriched for heterogeneous in vivo resistance mechanisms...
  65. Functional Analysis of Receptor Tyrosine Kinases in Glioblastoma Multiforme
    Jayne Stommel; Fiscal Year: 2009
    ..Aim 3: RTK function in tumor stem cells. It has been proposed that durable cures for cancer may require targeting tumor stem cells...
  66. Biochemical System Analyses of IdUrd in MMR+/- Cells
    Tomas Radivoyevitch; Fiscal Year: 2009
    ..iododeoxyuridine (IdUrd) incorporation into the DNA of quiescent cells as a model of the quiescent state of tumor stem cells;IdUrd radiosensitization is proportional to IdUrd-DNA and MMR- cells retain IdUrd-DNA longer than MMR+ cells...