mesenchymal stem cells

Summary

Summary: Cells that can develop into distinct mesenchymal tissue such as BONE; TENDONS; MUSCLES; ADIPOSE TISSUE; CARTILAGE; NERVE TISSUE; and BLOOD and BLOOD VESSELS.

Top Publications

  1. pmc Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms
    Darwin J Prockop
    Texas A and M Health Science Center, College of Medicine, Institute for Regenerative Medicine, Scott and White Hospital, Temple, Texas 76502 6954, USA
    Mol Ther 17:939-46. 2009
  2. pmc Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(High) forkhead box P3+ regulatory T cells
    K English
    Institute of Immunology, National University of Ireland Maynooth, Maynooth, Co Kildare, Ireland
    Clin Exp Immunol 156:149-60. 2009
  3. ncbi Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction
    Shao Liang Chen
    Division of Cardiology, Nanjing First Hospital, Nanjing University, Nanjing, Jiangsu Province, China
    Am J Cardiol 94:92-5. 2004
  4. pmc Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts
    Shuanhu Zhou
    Department of Orthopedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Aging Cell 7:335-43. 2008
  5. ncbi Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    M Dominici
    Laboratory of Cell Biology and Advanced Cancer Therapy, Oncology Hematology Department, University of Modena and Reggio Emilia, Modena, Italy
    Cytotherapy 8:315-7. 2006
  6. ncbi Matrix elasticity directs stem cell lineage specification
    Adam J Engler
    Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, 19104, USA
    Cell 126:677-89. 2006
  7. ncbi Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue
    Susanne Kern
    Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden Württemberg Hessen, Mannheim, Germany
    Stem Cells 24:1294-301. 2006
  8. ncbi Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views
    Donald G Phinney
    Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA
    Stem Cells 25:2896-902. 2007
  9. ncbi Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    Antoine E Karnoub
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 449:557-63. 2007
  10. ncbi Human mesenchymal stem cells modulate B-cell functions
    Anna Corcione
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Blood 107:367-72. 2006

Detail Information

Publications342 found, 100 shown here

  1. pmc Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms
    Darwin J Prockop
    Texas A and M Health Science Center, College of Medicine, Institute for Regenerative Medicine, Scott and White Hospital, Temple, Texas 76502 6954, USA
    Mol Ther 17:939-46. 2009
    ..Some of these issues will be reviewed in this study with special emphasis on how they can be applied to the adult stem/progenitor cells from bone marrow, referred to as MSCs...
  2. pmc Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(High) forkhead box P3+ regulatory T cells
    K English
    Institute of Immunology, National University of Ireland Maynooth, Maynooth, Co Kildare, Ireland
    Clin Exp Immunol 156:149-60. 2009
    ..Overall, this study provides a rational basis for ongoing clinical studies involving allogeneic MSC...
  3. ncbi Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction
    Shao Liang Chen
    Division of Cardiology, Nanjing First Hospital, Nanjing University, Nanjing, Jiangsu Province, China
    Am J Cardiol 94:92-5. 2004
    ..Several imagining techniques demonstrated that bone marrow mesenchymal stem cells significantly improved left ventricular function.
  4. pmc Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts
    Shuanhu Zhou
    Department of Orthopedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Aging Cell 7:335-43. 2008
    ..in vitro studies indicate that a subpopulation of human marrow-derived stromal cells (MSCs, also known as mesenchymal stem cells) has potential to differentiate into multiple cell types, including osteoblasts...
  5. ncbi Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    M Dominici
    Laboratory of Cell Biology and Advanced Cancer Therapy, Oncology Hematology Department, University of Modena and Reggio Emilia, Modena, Italy
    Cytotherapy 8:315-7. 2006
    ....
  6. ncbi Matrix elasticity directs stem cell lineage specification
    Adam J Engler
    Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, 19104, USA
    Cell 126:677-89. 2006
    ..Naive mesenchymal stem cells (MSCs) are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level ..
  7. ncbi Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue
    Susanne Kern
    Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden Württemberg Hessen, Mannheim, Germany
    Stem Cells 24:1294-301. 2006
    b>Mesenchymal stem cells (MSCs) represent a promising tool for new clinical concepts in supporting cellular therapy. Bone marrow (BM) was the first source reported to contain MSCs...
  8. ncbi Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views
    Donald G Phinney
    Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA
    Stem Cells 25:2896-902. 2007
    b>Mesenchymal stem cells or multipotent stromal cells (MSCs) isolated from the bone marrow of adult organisms were initially characterized as plastic adherent, fibroblastoid cells with the capacity to generate heterotopic osseous tissue ..
  9. ncbi Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    Antoine E Karnoub
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 449:557-63. 2007
    b>Mesenchymal stem cells have been recently described to localize to breast carcinomas, where they integrate into the tumour-associated stroma...
  10. ncbi Human mesenchymal stem cells modulate B-cell functions
    Anna Corcione
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Blood 107:367-72. 2006
    Human mesenchymal stem cells (hMSCs) suppress T-cell and dendritic-cell function and represent a promising strategy for cell therapy of autoimmune diseases...
  11. ncbi Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing
    Giselle Chamberlain
    Leopold Muller Arthritis Research Centre, School of Medicine, Keele University, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Shrops SY10 7AG, UK
    Stem Cells 25:2739-49. 2007
    ..The current review describes what is known about MSCs and their capacity to home to tissues together with the associated molecular mechanisms involving chemokine receptors and adhesion molecules...
  12. ncbi Mesenchymal stem cells reside in virtually all post-natal organs and tissues
    Lindolfo da Silva Meirelles
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Cell Sci 119:2204-13. 2006
    b>Mesenchymal stem cells (MSCs) are multipotent cells which can give rise to mesenchymal and non-mesenchymal tissues in vitro and in vivo...
  13. ncbi Immunomodulatory properties of mesenchymal stromal cells
    Alma J Nauta
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Blood 110:3499-506. 2007
    b>Mesenchymal stem cells (MSCs) are multipotential nonhematopoietic progenitor cells capable of differentiating into multiple lineages of the mesenchyme...
  14. ncbi Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals
    Farida Djouad
    INSERM U475, 99 rue Puech Villa, 34197 Montpellier Cedex 5, France
    Blood 102:3837-44. 2003
    b>Mesenchymal stem cells (MSCs) are largely studied for their potential clinical use. Recently, they have gained further interest after demonstration of an immunosuppressive role...
  15. ncbi Adult mesenchymal stem cells for tissue engineering versus regenerative medicine
    Arnold I Caplan
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio, USA
    J Cell Physiol 213:341-7. 2007
    Adult mesenchymal stem cells (MSCs) can be isolated from bone marrow or marrow aspirates and because they are culture-dish adherent, they can be expanded in culture while maintaining their multipotency...
  16. doi Why are MSCs therapeutic? New data: new insight
    A I Caplan
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Pathol 217:318-24. 2009
    Adult marrow-derived mesenchymal stem cells (MSCs) are able to differentiate into bone, cartilage, muscle, marrow stroma, tendon-ligament, fat and other connective tissues...
  17. doi Mesenchymal stem cells in health and disease
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy
    Nat Rev Immunol 8:726-36. 2008
    b>Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells that can be isolated from many adult tissues...
  18. pmc Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks
    Suling Liu
    Comprehensive Cancer Center and School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 71:614-24. 2011
    ..xenograft models to examine the interaction between breast cancer stem cells (CSC) and bone marrow-derived mesenchymal stem cells (MSC)...
  19. ncbi Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas
    Akira Nakamizo
    Department of Neurosurgery, Brain Tumor Center, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 65:3307-18. 2005
    ..recruited into solid organs in response to tissue stresses, we hypothesized that human bone marrow-derived mesenchymal stem cells (hMSC) may have a tropism for brain tumors and thus could be used as delivery vehicles for glioma therapy...
  20. ncbi Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy
    Emanuela Zappia
    Department of Neurosciences Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genoa, Italy
    Blood 106:1755-61. 2005
    We studied the immunoregulatory features of murine mesenchymal stem cells (MSCs) in vitro and in vivo. MSCs inhibited T-cell receptor (TCR)-dependent and -independent proliferation but did not induce apoptosis on T cells...
  21. pmc Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
    Federica Collino
    Department of Internal Medicine and Center for Molecular Biotechnology, University of Torino, Torino, Italy
    PLoS ONE 5:e11803. 2010
    ..MVs after internalization within target cells may deliver genetic information. Human bone marrow derived mesenchymal stem cells (MSCs) and liver resident stem cells (HLSCs) were shown to release MVs shuttling functional mRNAs...
  22. doi Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    Guangwen Ren
    Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 661 Hoes Lane, Piscataway, NJ 08854, USA
    Cell Stem Cell 2:141-50. 2008
    b>Mesenchymal stem cells (MSCs) can become potently immunosuppressive through unknown mechanisms...
  23. ncbi Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis
    Yaojiong Wu
    161 HMRC, University of Alberta, 113 Street and 87 Avenue, Edmonton, Alberta T6G 2E1, Canada
    Stem Cells 25:2648-59. 2007
    ..In this study, we examined the benefit of bone marrow-derived mesenchymal stem cells (BM-MSCs) in wound healing...
  24. ncbi Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease
    Rosa Yañez
    Hematopoiesis and Gene Therapy Division, Centro de Investigaciones Energeticas, Medioambientales y Technologicas CIEMAT Marcelino Botín Foundation, Madrid, Spain
    Stem Cells 24:2582-91. 2006
    ..These findings constitute the first experimental proof that Ad-MSCs can efficiently control the GVHD associated with allogeneic hematopoietic transplantation, opening new perspectives for the clinical use of Ad-MSCs...
  25. pmc Mesenchymal stem cell-derived microvesicles protect against acute tubular injury
    Stefania Bruno
    Department of Internal Medicine, Research Center for Experimental Medicine, University of Torino, Torino, Italy
    J Am Soc Nephrol 20:1053-67. 2009
    Administration of mesenchymal stem cells (MSCs) improves the recovery from acute kidney injury (AKI)...
  26. pmc Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis
    Dimitrios Karussis
    Department of Neurology, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem IL 91120, Israel
    Arch Neurol 67:1187-94. 2010
    ..feasibility, safety, and immunological effects of intrathecal and intravenous administration of autologous mesenchymal stem cells (MSCs) (also called mesenchymal stromal cells) in patients with multiple sclerosis (MS) and amyotrophic ..
  27. pmc Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease
    Adam R Williams
    Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Circ Res 109:923-40. 2011
    b>Mesenchymal stem cells (MSCs) are a prototypical adult stem cell with capacity for self-renewal and differentiation with a broad tissue distribution...
  28. doi Mechanisms involved in the therapeutic properties of mesenchymal stem cells
    Lindolfo da Silva Meirelles
    National Institute of Science and Technology for Stem Cells and Cell Therapy, Centro Regional de Hemoterapia de Ribeirão Preto HCFMRP Universidade de São Paulo, Ribeirao Preto, SP 14051 140, Brazil
    Cytokine Growth Factor Rev 20:419-27. 2009
    b>Mesenchymal stem cells (MSCs) have been described as being able to give rise to several quite different mesenchymal cell phenotypes...
  29. pmc Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung
    Jae W Lee
    Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:16357-62. 2009
    Recent studies have suggested that bone marrow-derived multipotent mesenchymal stem cells (MSCs) may have therapeutic applications in multiple clinical disorders including myocardial infarction, diabetes, sepsis, and hepatic and acute ..
  30. pmc Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
    Aarif Y Khakoo
    Laboratory of Molecular Biology, Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:1235-47. 2006
    ..v.) injected human mesenchymal stem cells (MSCs) home to sites of tumorigenesis and potently inhibit tumor growth...
  31. ncbi Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials
    Lu Lu Lü
    National Engineering Research Center of Cell Products, AmCellGene Co Ltd
    Haematologica 91:1017-26. 2006
    Adult bone marrow (BM) is the major source of mesenchymal stem cells (MSC) for cell therapy. However, aspiration of BM involves invasive procedures. We isolated MSC from human full term umbilical cord tissues (UC)...
  32. ncbi Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells
    Xiao Xia Jiang
    Department of Cell Biology, Institute of Basic Medical Sciences, Tai Ping Road 27, Beijing 100850, PR China
    Blood 105:4120-6. 2005
    b>Mesenchymal stem cells (MSCs), in addition to their multilineage differentiation, have a direct immunosuppressive effect on T-cell proliferation in vitro...
  33. doi A perivascular origin for mesenchymal stem cells in multiple human organs
    Mihaela Crisan
    Department of Pediatrics, Stem Cell Research Center, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Cell Stem Cell 3:301-13. 2008
    b>Mesenchymal stem cells (MSCs), the archetypal multipotent progenitor cells derived in cultures of developed organs, are of unknown identity and native distribution...
  34. pmc Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury
    Luis A Ortiz
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 104:11002-7. 2007
    b>Mesenchymal stem cells (MSCs) have been exploited as cellular vectors to treat a wide array of diseases but the mechanisms responsible for their therapeutic effect remain indeterminate...
  35. pmc Concise review: Induced pluripotent stem cell-derived mesenchymal stem cells: progress toward safe clinical products
    Yunjoon Jung
    Department of Biomedical Engineering, University of California, Davis, Sacramento, California 95817, USA
    Stem Cells 30:42-7. 2012
    ..Here, we describe the status of the progress of the use of MSC and PSCs in clinical trials and analyze the challenges that should be overcome before iPSC-derived MSC therapy can be used widely in the clinic...
  36. ncbi Mesenchymal stem cells and their potential as cardiac therapeutics
    Mark F Pittenger
    Osiris Therapeutics, Inc, 2001 Aliceanna St, Baltimore, MD 21231, USA
    Circ Res 95:9-20. 2004
    b>Mesenchymal stem cells (MSCs) represent a stem cell population present in adult tissues that can be isolated, expanded in culture, and characterized in vitro and in vivo...
  37. ncbi Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood
    Wolfgang Wagner
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Exp Hematol 33:1402-16. 2005
    Various preparative protocols have been proposed for the acquisition and cultivation of mesenchymal stem cells (MSC)...
  38. pmc Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine
    G T J Huang
    University of Maryland, College of Dental Surgery, Dental School, Department of Endodontics, Prosthodontics and Operative Dentistry, 650 West Baltimore St, Baltimore, MD 21201, USA
    J Dent Res 88:792-806. 2009
    ..Important issues in stem cell biology, such as stem cell niche, homing, and immunoregulation, will also be discussed...
  39. pmc TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation
    Yi Tang
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nat Med 15:757-65. 2009
    ..coordinates bone formation by inducing migration of bone marrow stromal cells, also known as bone mesenchymal stem cells, to the bone resorptive sites and that this process is mediated through a SMAD signaling pathway...
  40. pmc Concise review: Mesenchymal stem cells for acute lung injury: role of paracrine soluble factors
    Jae W Lee
    Department of Anesthesiology, University of California San Francisco, California 94143, USA
    Stem Cells 29:913-9. 2011
    ..Consequently, further research in translational therapies is needed. Cell-based therapy with mesenchymal stem cells (MSCs) is one attractive new therapeutic approach...
  41. ncbi Mesenchymal stem cells: clinical applications and biological characterization
    Frank P Barry
    Osiris Therapeutics Inc, 2001 Aliceanna Street, Baltimore, MD 21231, USA
    Int J Biochem Cell Biol 36:568-84. 2004
    b>Mesenchymal stem cells (MSCs) have been isolated from bone marrow, periosteum, trabecular bone, adipose tissue, synovium, skeletal muscle and deciduous teeth...
  42. pmc Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression
    Erika L Spaeth
    Department of Stem Cell Transplantation and Cellular Therapy, Section of Molecular Hematology and Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 4:e4992. 2009
    ..There are several suggested origins of the TAF including tissue-resident, circulating, and epithelial-to-mesenchymal-transitioned cells...
  43. ncbi Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents
    Matus Studeny
    Department of Blood and Marrow Transplantation, Section of Molecular Hematology and Therapy, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 448, Houston, TX 77030, USA
    J Natl Cancer Inst 96:1593-603. 2004
    ..b>Mesenchymal stem cells (MSC) can be used to target delivery of agents to tumor cells...
  44. ncbi The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities
    Adriana López Ponte
    Laboratoire d Hématopoïèse, Institut National de la Santé et de la Recherche Médicale ER15, IFR135 Université François Rebelais, Tours, France
    Stem Cells 25:1737-45. 2007
    ..Our results suggest that the mobilization of MSCs and their subsequent homing to injured tissues may depend on the systemic and local inflammatory state. Disclosure of potential conflicts of interest is found at the end of this article...
  45. ncbi Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta
    Pieternella S In 't Anker
    Department of Obstetrics, Lieden University Medical Center, Leiden, The Netherlands
    Stem Cells 22:1338-45. 2004
    Recently we reported that second-trimester amniotic fluid (AF) is an abundant source of fetal mesenchymal stem cells (MSCs). In this study, we analyze the origin of these MSCs and the presence of MSCs in human-term AF...
  46. pmc Replicative senescence of mesenchymal stem cells: a continuous and organized process
    Wolfgang Wagner
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 3:e2213. 2008
    b>Mesenchymal stem cells (MSC) comprise a promising tool for cellular therapy. These cells are usually culture expanded prior to their application...
  47. ncbi Immunophenotype of human adipose-derived cells: temporal changes in stromal-associated and stem cell-associated markers
    James B Mitchell
    Cognate Therapeutics, Inc, Baltimore, MD, USA
    Stem Cells 24:376-85. 2006
    ....
  48. ncbi SSEA-4 identifies mesenchymal stem cells from bone marrow
    Eun J Gang
    Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas 75390 9133, USA
    Blood 109:1743-51. 2007
    ..Within this stromal population are mesenchymal stem cells (MSCs), which not only support hematopoiesis but also differentiate into multiple lineages, including fat, ..
  49. pmc Mesenchymal stem cells: revisiting history, concepts, and assays
    Paolo Bianco
    Cell Stem Cell 2:313-9. 2008
    The concept of mesenchymal stem cells has gained wide popularity. Despite the rapid growth of the field, uncertainties remain with respect to the defining characteristics of these cells, including their potency and self-renewal...
  50. ncbi Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells
    Mauro Krampera
    Department of Clinical and Experimental Medicine, University of Verona, Italy
    Stem Cells 24:386-98. 2006
    b>Mesenchymal stem cells (MSCs) inhibit the proliferation of HLA-unrelated T lymphocytes to allogeneic stimulation, but the mechanisms responsible for this activity are not fully understood...
  51. ncbi Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease
    Olle Ringden
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Transplantation 81:1390-7. 2006
    b>Mesenchymal stem cells (MSC) have immunomodulatory effects. The aim was to study the effect of MSC infusion on graft-versus-host disease (GVHD).
  52. pmc How to track cellular aging of mesenchymal stromal cells?
    Wolfgang Wagner
    Helmholtz Institute for Biomedical Engineering, Department of Cell Biology, RWTH Aachen University Medical School, 52074 Aachen, Germany
    Aging (Albany NY) 2:224-30. 2010
    ..Molecular analysis of a suitable panel of genes might provide a robust tool to assess efficiency and safety of long-term expansion...
  53. pmc The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in
    Armin Ehninger
    Division of Stem Cells and Cancer, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Exp Med 208:421-8. 2011
    ..Recent studies have expanded the number of cell types contributing to the HSC niche. Perivascular mesenchymal stem cells and macrophages now join the previously identified sinusoidal endothelial cells, sympathetic nerve fibers, ..
  54. pmc Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation
    Konstantinos E Hatzistergos
    University of Miami Miller School of Medicine, Interdisciplinary Stem Cell Institute, Miami, FL 33136, USA
    Circ Res 107:913-22. 2010
    ..Bone marrow-derived mesenchymal stem cells (MSCs) have the capacity for cardiac repair that appears to exceed their capacity for differentiation into ..
  55. ncbi Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells
    Alma J Nauta
    Laboratory of Experimental Hematology, Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Immunol 177:2080-7. 2006
    b>Mesenchymal stem cells (MSCs) are not only able to evade the immune system, but they have also been demonstrated to exert profound immunosuppressive properties on T cell proliferation...
  56. ncbi Mesenchymal stem cells can be differentiated into endothelial cells in vitro
    Joachim Oswald
    Institute of Polymer Research Dresden and The Max Bergmann Center of Biomaterials Dresden, Dresden, Germany
    Stem Cells 22:377-84. 2004
    Human bone marrow-derived mesenchymal stem cells (MSCs) have the potential to differentiate into mesenchymal tissues like osteocytes, chondrocytes, and adipocytes in vivo and in vitro...
  57. ncbi Adipocyte differentiation from the inside out
    Evan D Rosen
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nat Rev Mol Cell Biol 7:885-96. 2006
    ....
  58. doi PDGF, TGF-beta, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and o
    Felicia Ng
    Genome and Gene Expression Analysis Group, Bioinformatics Institute, Agency for Science Technology and Research A STAR, Singapore
    Blood 112:295-307. 2008
    We compared the transcriptomes of marrow-derived mesenchymal stem cells (MSCs) with differentiated adipocytes, osteocytes, and chondrocytes derived from these MSCs...
  59. ncbi Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+ regulatory T cells
    Zohair Selmani
    Institut National de la Santé et de la Recherche Médicale U645, IFR 133, Universite de Franche Comte, Etablissement Français du Sang Bourgogne Franche Comté, Besancon, France
    Stem Cells 26:212-22. 2008
    Adult bone marrow-derived mesenchymal stem cells (MSCs) are multipotent cells that are the subject of intense investigation in regenerative medicine...
  60. pmc Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
    Simon Mendez-Ferrer
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 466:829-34. 2010
    ..Here we demonstrate that mesenchymal stem cells (MSCs), identified using nestin expression, constitute an essential HSC niche component...
  61. ncbi Isolation of human multipotent mesenchymal stem cells from second-trimester amniotic fluid using a novel two-stage culture protocol
    Ming Song Tsai
    Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan
    Hum Reprod 19:1450-6. 2004
    The aim of this study was to isolate mesenchymal stem cells (MSCs) from amniotic fluid obtained by second-trimester amniocentesis.
  62. ncbi Interactions between human mesenchymal stem cells and natural killer cells
    Panagiota A Sotiropoulou
    Cancer Immunology and Immunotherapy Center, Saint Savas Hospital, 171 Alexandras Ave, 115 22, Athens, Greece
    Stem Cells 24:74-85. 2006
    b>Mesenchymal stem cells (MSCs) are multipotent progenitor cells representing an attractive therapeutic tool for regenerative medicine...
  63. ncbi Mesenchymal stem cells: a perspective from in vitro cultures to in vivo migration and niches
    Andrea Augello
    Regenerative Medicine Unit, Division of Applied Medicine, University of Aberdeen, Aberdeen, UK
    Eur Cell Mater 20:121-33. 2010
    ....
  64. doi Markers distinguishing mesenchymal stem cells from fibroblasts are downregulated with passaging
    Svetlana Halfon
    Teva Pharmaceutical Industries, Rehovot, Israel
    Stem Cells Dev 20:53-66. 2011
    Expansion of plastic-adherent bone marrow-derived mesenchymal stem cells (MSCs) results in gradual loss of osteogenic potential after passage 5-6. One explanation is contamination of MSC cultures with mature cells including fibroblasts...
  65. doi Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells
    Tobias Deuse
    Cardiovascular Surgery, University Heart Center Hamburg, Germany
    Cell Transplant 20:655-67. 2011
    We here present an immunologic head-to-head comparison between human umbilical cord lining mesenchymal stem cells (clMSCs) and adult bone marrow MSCs (bmMSCs) from patients >65 years of age...
  66. doi Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype
    Soufiane Ghannam
    Institut National de la Sante et de la Recherche Medicale, Unité 844, Hopital St Eloi, Universite Montpellier I, France
    J Immunol 185:302-12. 2010
    b>Mesenchymal stem cells (MSCs) exert immunomodulatory properties via the inhibition of T cell activation and proliferation...
  67. doi Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts
    Dimas T Covas
    Department of Clinical Medicine, Center for Cell Therapy and Regional Blood Center, University of Sao Paulo, Ribeirao Preto, Brazil
    Exp Hematol 36:642-54. 2008
    ....
  68. ncbi Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness
    Shaul Beyth
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel
    Blood 105:2214-9. 2005
    Infusion of either embryonic or mesenchymal stem cells prolongs the survival of organ transplants derived from stem cell donors and prevents graft-versus-host-disease (GVHD)...
  69. ncbi A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells
    W J Wan Ju Li
    Department of Health and Human Services, Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institute of Health, Bethesda, MD 20892, USA
    Biomaterials 26:599-609. 2005
    ..Adult bone marrow derived mesenchymal stem cells (MSCs) are undifferentiated, multipotential cells which are capable of giving rise to chondrocytes when ..
  70. ncbi In vitro expansion of human mesenchymal stem cells: choice of serum is a determinant of cell proliferation, differentiation, gene expression, and transcriptome stability
    Aboulghassem Shahdadfar
    Institute of Immunology, Rikshospitalet University Hospital, 0027 Oslo, Norway
    Stem Cells 23:1357-66. 2005
    Human bone marrow mesenchymal stem cells (hMSCs) represent an appealing source of adult stem cells for cell therapy and tissue engineering, as they are easily obtained and expanded while maintaining their multilineage differentiation ..
  71. ncbi Sarcoma derived from cultured mesenchymal stem cells
    Jakub Tolar
    Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplant and Cancer Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Stem Cells 25:371-9. 2007
    ..More importantly, our study indicates that sarcoma can evolve from MSC cultures...
  72. ncbi Immunosuppressive effects of mesenchymal stem cells: involvement of HLA-G
    Aisha Nasef
    INSERM, U832, Universite Pierre et Marie Curie PARIS6, Paris, France
    Transplantation 84:231-7. 2007
    b>Mesenchymal stem cells (MSCs) possess unique immunomodulatory properties. They are able to suppress allogenic T-cell response and modify maturation of antigen-presenting cells...
  73. ncbi Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement
    E M Horwitz
    Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cytotherapy 7:393-5. 2005
    The plastic-adherent cells isolated from BM and other sources have come to be widely known as mesenchymal stem cells (MSC)...
  74. pmc Stem cell fate dictated solely by altered nanotube dimension
    Seunghan Oh
    Department of Materials Science and Engineering, University California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:2130-5. 2009
    ....
  75. ncbi Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source
    Yusuke Sakaguchi
    Tokyo Medical and Dental University, Japan
    Arthritis Rheum 52:2521-9. 2005
    To compare the properties of human mesenchymal stem cells (MSCs) isolated from bone marrow, synovium, periosteum, skeletal muscle, and adipose tissue.
  76. ncbi Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2
    Grazia Maria Spaggiari
    Centro di Eccellenza per la Ricerca Biomedica, Biologia e Genetica, Universita di Genova, Genova, Italy
    Blood 111:1327-33. 2008
    Recently, a number of clinical trials used either mesenchymal stem cells (MSCs) or natural killer (NK) cells in an attempt to improve the effectiveness of hematopoietic stem cell transplantation (HSCT)...
  77. pmc Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing
    Liwen Chen
    Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 3:e1886. 2008
    Bone marrow derived mesenchymal stem cells (BM-MSCs) have been shown to enhance wound healing; however, the mechanisms involved are barely understood...
  78. doi Mesenchymal stem cell homing: the devil is in the details
    Jeffrey M Karp
    Harvard MIT Division of Health Science and Technology, 77 Massachusetts Avenue, E25 519, Cambridge, MA 02139, USA
    Cell Stem Cell 4:206-16. 2009
    ..This review provides a critical analysis of the methods used to track homing of exogenously infused MSCs and discusses strategies for enhancing their trafficking to particular tissues...
  79. doi Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo
    Daan van Poll
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children, Boston, MA, USA
    Hepatology 47:1634-43. 2008
    ..Direct antiapoptotic and promitotic effects of MSC-CM on hepatocytes were demonstrated using in vitro assays...
  80. ncbi Immunomodulation by mesenchymal stem cells and clinical experience
    K Le Blanc
    Division of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Intern Med 262:509-25. 2007
    b>Mesenchymal stem cells (MSCs) from adult marrow can differentiate in vitro and in vivo into various cell types, such as bone, fat and cartilage. MSCs preferentially home to damaged tissue and may have therapeutic potential...
  81. doi Immunomodulatory properties of mesenchymal stromal cells and their therapeutic consequences for immune-mediated disorders
    Senming Zhao
    Institute of Immunology, Technical University of Dresden, Fetscherstr 74, Dresden 01307, Germany
    Stem Cells Dev 19:607-14. 2010
    ..Due to their immunomodulatory capability and their low immunogenicity, MSCs represent promising candidates for the prevention and treatment of immune-mediated diseases...
  82. ncbi Platelet lysates promote mesenchymal stem cell expansion: a safety substitute for animal serum in cell-based therapy applications
    Christelle Doucet
    Département Recherches, centre de transfusion sanguine des armées Jean Julliard, Clamart Cedex, France
    J Cell Physiol 205:228-36. 2005
    b>Mesenchymal stem cells (MSCs) are considered as emergent "universal" cells and various tissue repair programs using MSCs are in development...
  83. pmc Human ovarian carcinoma–associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production
    Karen McLean
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Clin Invest 121:3206-19. 2011
    Accumulating evidence suggests that mesenchymal stem cells (MSCs) are recruited to the tumor microenvironment; however, controversy exists regarding their role in solid tumors...
  84. pmc Mesenchymal stem cells: Mechanisms of immunomodulation and homing
    Hiroshi Yagi
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Shriners Hospitals for Children and Harvard Medical School, Boston, MA, USA
    Cell Transplant 19:667-79. 2010
    ..These aspects of MSC grafts--immunomodulation and homing--are contextualized to understand a reported side effect of MSC therapy, cancer development...
  85. doi Oct4 and Nanog directly regulate Dnmt1 to maintain self-renewal and undifferentiated state in mesenchymal stem cells
    Chih Chien Tsai
    Institute of Pharmacology, Faculty of Medicine, National Yang Ming University, Taipei 112, Taiwan
    Mol Cell 47:169-82. 2012
    ..differentiation were observed in early-passage (E), hypoxic culture (H), and p21 knockdown (p21KD) mesenchymal stem cells (MSCs) compared to late-passage (L), normoxic culture (N), and scrambled shRNA-overexpressed (Scr) MSCs...
  86. ncbi The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder
    Matthew J Dalby
    Centre for Cell Engineering, Joseph Black Building, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK
    Nat Mater 6:997-1003. 2007
    ..Here, we demonstrate the use of nanoscale disorder to stimulate human mesenchymal stem cells (MSCs) to produce bone mineral in vitro, in the absence of osteogenic supplements...
  87. pmc Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells
    Tom K Kuo
    Institute of Biopharmaceutical Science, National Yang Ming University, Taipei, Taiwan
    Gastroenterology 134:2111-21, 2121.e1-3. 2008
    ..We previously reported that multipotent bone marrow-derived mesenchymal stem cells differentiate into functional hepatocyte-like cells with almost 100% induction frequency under defined ..
  88. ncbi Human mesenchymal stem cells require monocyte-mediated activation to suppress alloreactive T cells
    Margaret E Groh
    Division of Hematology Oncology, Department of Medicine, Case Comprehensive Cancer Center at Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Exp Hematol 33:928-34. 2005
    ..The interaction between blood monocytes and the MSCs represents a unique immune regulatory paradigm that can potentially be exploited in clinic...
  89. ncbi Mesenchymal stem cell features of Ewing tumors
    Franck Tirode
    Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Cancer Cell 11:421-9. 2007
    ..tissues, we show that the profiles of different EWS-FLI1-silenced Ewing cell lines converge toward that of mesenchymal stem cells (MSC)...
  90. ncbi Spontaneous human adult stem cell transformation
    Daniel Rubio
    Department of Immunology and Oncology, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, UAM Campus de Cantoblanco, Darwin, 3 E 28049 Madrid, Spain
    Cancer Res 65:3035-9. 2005
    ..that although they can be managed safely during the standard ex vivo expansion period (6-8 weeks), human mesenchymal stem cells can undergo spontaneous transformation following long-term in vitro culture (4-5 months)...
  91. ncbi Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord
    Hwai Shi Wang
    Institute of Anatomy and Cell Biology, Yang Ming University, Taipei, Taiwan, Republic of China
    Stem Cells 22:1330-7. 2004
    ....
  92. pmc Geometric cues for directing the differentiation of mesenchymal stem cells
    Kristopher A Kilian
    Department of Chemistry, and Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 107:4872-7. 2010
    ..that cell shape, independent of soluble factors, has a strong influence on the differentiation of human mesenchymal stem cells (MSCs) from bone marrow...
  93. pmc Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses
    Hirokazu Ohtaki
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 105:14638-43. 2008
    ..The observed beneficial effects of hMSCs were largely explained by their modulation of inflammatory and immune responses, apparently by alternative activation of microglia and/or macrophages...
  94. doi Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury
    Stefano Gatti
    Center for Surgical Research, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Italy
    Nephrol Dial Transplant 26:1474-83. 2011
    Several studies demonstrated that mesenchymal stem cells (MSCs) reverse acute kidney injury (AKI) by a paracrine mechanism rather than by MSC transdifferentiation...
  95. ncbi Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice
    Naveen Gupta
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 179:1855-63. 2007
    Recent in vivo and in vitro work suggests that mesenchymal stem cells (MSC) have anti-inflammatory properties...
  96. doi Human mesenchymal stem cells in synovial fluid increase in the knee with degenerated cartilage and osteoarthritis
    Ichiro Sekiya
    Section of Cartilage Regeneration, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Orthop Res 30:943-9. 2012
    We investigated whether mesenchymal stem cells (MSCs) in synovial fluid (SF) increased in the knee with degenerated cartilage and osteoarthritis...
  97. doi Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression
    Guangwen Ren
    Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA
    Stem Cells 27:1954-62. 2009
    Bone marrow-derived mesenchymal stem cells (MSCs) hold great promise for treating immune disorders because of their immunoregulatory capacity, but the mechanism remains controversial...
  98. pmc Stem cell homing in musculoskeletal injury
    Eliza L S Fong
    Division of Bioengineering, National University of Singapore, Singapore
    Biomaterials 32:395-409. 2011
    ....
  99. pmc CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells
    Yongkun Wei
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Nat Cell Biol 13:87-94. 2011
    ..In human mesenchymal stem cells, activation of CDK1 promoted mesenchymal stem cell differentiation into osteoblasts through ..
  100. doi Mesenchymal stem cells attenuate renal fibrosis through immune modulation and remodeling properties in a rat remnant kidney model
    Patricia Semedo
    Nephrology Division, Medicine Department, Federal University of Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Stem Cells 27:3063-73. 2009
    b>Mesenchymal stem cells (MSCs) have regenerative properties in acute kidney injury, but their role in chronic kidney diseases is still unknown. More specifically, it is not known whether MSCs halt fibrosis...
  101. pmc Concise review: hitting the right spot with mesenchymal stromal cells
    Jakub Tolar
    Division of Hematology, Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Stem Cells 28:1446-55. 2010
    Mesenchymal stromal cells or mesenchymal stem cells (MSCs) have captured considerable scientific and public interest because of their potential to limit physical and immune injury, to produce bioactive molecules and to regenerate tissues...

Research Grants76

  1. Immunomodulatory and regenerative effects of mesenchymal stem cells on allografts
    Norma S Kenyon; Fiscal Year: 2013
    ..Furthermore, MSC administration may constitute a safe and effective way to reverse rejection episodes. ..
  2. Regulation of myocardial growth and death by GSK-3
    Junichi Sadoshima; Fiscal Year: 2013
    ..cardiac hypertrophy, ischemia/reperfusion (I/R) and differentiation of bone marrow (BM)-derived mesenchymal stem cells (MSCs) by focusing on novel connections between GSK-3 isoforms and their downstream targets...
  3. Identification of Proteins Important for Male Osteoporosis
    Hong Wen Deng; Fiscal Year: 2013
    ..Bone marrow mesenchymal stem cells (BMMSCs) and peripheral blood monocytes (PBMs) are precursors for osteoblasts (bone formation cells) and ..
  4. Stem Cell Homing for Treatment of Female Pelvic Floor Disorders
    Margot S Damaser; Fiscal Year: 2013
    ..The hypothesis to be tested in this project is that mesenchymal stem cells home to pelvic organs after delivery, facilitate recovery, and prevent resultant FPFD via secretion of ..
  5. Mechanisms of Stem Cell Self-Renewal and Aging
    PAUL CHRISTIAN SCHILLER; Fiscal Year: 2013
    ..Aim 3: Determine the role of progerin in the bone forming capacity of hMSCs in vivo. We expect that increased progerin expression in hMSCs will decrease their bone forming capacity in vivo. ..
  6. Heat Shock Effects on Human Mesenchymal Stem Cell Differentiation in Hydrogel
    Sihong Wang; Fiscal Year: 2010
    ..the maturature levels of osteoblasts (bone cells) and chondrocytes (cartilage cells) differentiated from mesenchymal stem cells. With increased maturature, differentiated cells are better to perform functions similar to adult cells in ..
  7. Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
    Catherine M Gordon; Fiscal Year: 2013
    ..raised by the pilot imaging data, in particular whether hormonal abnormalities in girls with AN influence mesenchymal stem cells to differentiate preferentially into adipocytes over osteoblasts...
  8. Mechanism of Irradiation Pulmonary Fibrosis
    Joel S Greenberger; Fiscal Year: 2012
    ..and proliferation of bone marrow origin myofibroblast progenitor cells (bone marrow stromal cells/mesenchymal stem cells), which contribute to pulmonary fibrosis...
  9. Hematopoietic Stem Cell Transplantation in Osteogenesis Imperfecta
    Meenal Mehrotra; Fiscal Year: 2012
    ..Current dogma states that bone marrow contains two types of stem cells, HSCs and mesenchymal stem cells (MSCs), and that their repertoire of reconstituting potentials are distinct and separate from each other;i...
  10. Use of umbilical cord as a unique stem cell source for tissue regeneration
    Xiao Dong Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human umbilical cord blood (UCB) contains mesenchymal stem cells (MSCs) that have higher multipotentiality than adult marrow-derived MSCs (BM-MSCs)...
  11. Maternal Obesity affects AMP-Kinase in Muscle Cell Differentiation
    Min Du; Fiscal Year: 2013
    ..Myocytes, adipocytes and fibroblasts in fetal SM are derived from mesenchymal stem cells (MSC)...
  12. Regulation of Chronic Colitis by Mesenchymal Stem Cells
    Matthew B Grisham; Fiscal Year: 2013
    ..Recent studies demonstrate that bone marrow-derived mesenchymal stem cells (MSCs) have potent immunoregulatory activity in vitro and in vivo...
  13. Stem Cell Based Therapy For Radiation Induced Gastrointestinal Syndrome
    Chandan Guha; Fiscal Year: 2010
    ..signaling in resident macrophages and ISC, and c) transplantation of bone marrow-derived endothelial and mesenchymal stem cells to restore the IR-damaged ISC niche would augment host ISC regeneration and repair of the ISC niche in ..
  14. Mechanisms mediating hematopoietic stem and progenitor cell trafficking
    Paul S Frenette; Fiscal Year: 2013
    ..Here, we will explore further the hypothesis that the retention of hematopoietic stem and progenitor cells in the niche is regulated by differing signals from the sympathetic nervous system and macrophages. ..
  15. Endothelial Progenitor Cells and Particulate Air Pollution
    Arden Pope; Fiscal Year: 2013
    ..whether this response is selective to EPCs or other stem cells such as the hematopoietic stem cells and mesenchymal stem cells are affected as well...
  16. Stem cell-mediated delivery of neurotrophic factors for treatment of glaucoma
    Donald S Sakaguchi; Fiscal Year: 2010
    ..glia cell line-derived neurotrophic factor (GDNF)] via intraocular transplantation of genetically modified mesenchymal stem cells (MSCs) to eyes damaged by laserinduced chronic ocular hypertension and RGC injury...
  17. Differentiation of Cord Blood Mesenchymal Stem Cells to Corneal Endothelium
    Nancy C Joyce; Fiscal Year: 2010
    ..The proposed exploratory studies are based on the fact that mesenchymal stem cells from several sources, including human umbilical cord blood, have the potential to differentiate into ..
  18. Regenerating Human Oral Mucosa by Bone Marrow-derived Mesenchymal Stem Cells
    RUBIE ANN RAKIAN; Fiscal Year: 2013
    ..The proposed research studies will address the capacity of bone marrow-derived mesenchymal stem cells (MSC) to regenerate the oral mucosa epithelium by mimicking an environment in vitro similar to that seen ..
  19. Skin Regeneration with Stem Cells and Scaffolds
    SUSAN RENEE OPALENIK; Fiscal Year: 2013
    ..We have published evidence that the bone marrow is a rich source of wound fibroblasts, and mesenchymal stem cells (MSC) from the MRL mouse enhance healing due in part to elevated sFRP-1...
  20. In vivo imaging of encapsulated stem cells in mouse models of tumor resection
    Khalid A Shah; Fiscal Year: 2013
    ..Based on our recent findings that encapsulation of mesenchymal stem cells (MSC) is necessary to prevent rapid "wash- out" of stem cells post-transplantation in the tumor resection ..
  21. Tissue recovery in the pathophysiology of stress urinary incontinence
    Adonis K Hijaz; Fiscal Year: 2013
    ..the continence mechanisms (urethra);2) to examine the therapeutic impact of intravenously injected human mesenchymal stem cells (hMSCs) in recovery of VD- induced SUI in the same group of mice using similar outcome measures...
  22. FUNCTION AND REGULATION OF OSTEONECTIN IN BONE
    Anne M Delany; Fiscal Year: 2013
    ..b>Mesenchymal stem cells (MSCs) give rise to both osteoblasts and adipocytes, and MSC lineage allocation is altered in aging...
  23. Regenerative Adjuvant Therapy for Stress Urinary Incontinence
    Margot S Damaser; Fiscal Year: 2011
    ..Stem cell homing cytokines are upregulated after VD, particularly those that attract adult mesenchymal stem cells (MSCs), and infusion of MSCs after VD results in accelerated recovery of SUI...
  24. Inflammation and Cerebral Aneurysm Formation: Targets for Modulation and Vascular
    BRIAN LIM HOH; Fiscal Year: 2013
    ..cell-specific populations of CD133+ endothelial progenitor cells (EPCs), hematopoietic stem cells, and mesenchymal stem cells will be seeded into Matrigel and other polymers developed by our collaborator, Dr...
  25. 3D Differentiation of Mesenchymal Stem Cells in Peptide Amphiphile Matrices
    John B Matson; Fiscal Year: 2011
    ..The proposed work details a strategy for inducing the differentiation of human mesenchymal stem cells (hMSCs) into osteoblastic lineage inside a three dimensional scaffold, with applications in bone ..
  26. Cell Based Therapies for Cystic Fibrosis
    Tracey L Bonfield; Fiscal Year: 2012
    ..in this proposal are aimed at evaluating whether bone marrow transplantation or adult human derived mesenchymal stem cells therapy has a beneficial effect on inflammatory outcomes in the course of infection with Pseudomonas ..
  27. Development of an In Vivo Stem Cell Tracking Method Using Ultrasound Imaging
    Flordeliza S Villanueva; Fiscal Year: 2010
    ..infarction, delivery of cell preparations such as unfractionated adult bone marrow or marrow-derived mesenchymal stem cells (MSCs) has improved perfusion and indices of ventricular function...
  28. Targeted cell therapy for the treatment of ventricular tachycardia
    KENNETH LAURITA; Fiscal Year: 2010
    ..Consequently, SCD remains a major unresolved public health problem. This proposal puts forth a novel method using targeted cellular therapy to restore normal function and, thus, cure many patients at risk for SCD. 1 ..
  29. Developing diagnostic and therapeutic stem cells for cancer therapy
    Khalid A Shah; Fiscal Year: 2013
    ..In this proposal, we will create toxin resistant human mesenchymal stem cells (MSC) for on-site delivery of targeted nanobodies and cytotoxic agents to simultaneously block ..
  30. Immunosuppression by Adult Stem Cells
    Yufang Shi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mesenchymal stem cells (MSCs) are strongly immunosuppressive in vivo and in vitro in both animals and humans...
  31. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad H Chaudry; Fiscal Year: 2012
    ..e., administration of genetically modified bone marrow mesenchymal stem cells (MSC) to over-express ER will upregulate ERs in cells and improve organ function after T-H even in the ..
  32. Transcriptional and epigenomic control of adipose tissue development and function
    David J Steger; Fiscal Year: 2013
    ..will be tested by performing ChIAPET for GR and CEBP[unreadable] during adipocyte differentiation of human mesenchymal stem cells (hMSCs)...
  33. RV/PA Recoupling by Bone Marrow Derived Mesenchymal Stem Cells
    Luis A Ortiz; Fiscal Year: 2013
    ....
  34. Extracellular Scaffold Elasticity and Binding Sites in Acinar Differentiation
    Melinda Larsen; Fiscal Year: 2013
    ..the importance of elasticity of the microenvironment in determining the extent of differentiation of mesenchymal stem cells;however, the significance of elasticity in regulation of epithelial tissue differentiation has not been ..
  35. Synthesis of bone-selective osteogenic oxysterols
    Frank Stappenbeck; Fiscal Year: 2013
    ..Multipotent mesenchymal stem cells (MSCs) are precursors of a variety of cell types, including osteoblasts and adipocytes...
  36. Reprogramming of endothelial cells for improved cardiomyogenicity in vivo
    MELISSA ANN THAL; Fiscal Year: 2012
    ..For instance, mesenchymal stem cells (MSC) treated with 5'Azacytidine have an increase in cardiomyocyte differentiation and they improve ..
  37. Mesenchymal Stem Cells for Treatment of Retinal Diseases
    Martin L Katz; Fiscal Year: 2011
    ..We propose to investigate the possibility of using implantation of genetically modified autologous mesenchymal stem cells (MSCs) for sustained delivery of enzymes with therapeutic potential...
  38. Isolation of novel mesenchymal stem cell subpopulations
    Buddhadeb Dawn; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Although therapy with adult bone marrow (BM)-derived unfractionated mesenchymal stem cells (MSCs) improves cardiac function, remodeling, and perfusion after MI, the extents of MSC-induced angiogenesis,..
  39. A novel model for studying fetal skeletal muscle development
    Min Du; Fiscal Year: 2009
    ..Fetal muscle up to late gestation contains a large number of mesenchymal stem cells (pluripotent progenitor cells)...
  40. AUGMENTATION OF TRABECULAR BONE BY LOW MAGNITUDE STRAIN
    Clinton T Rubin; Fiscal Year: 2012
    ..bone &muscle;?fat) to LMMS suggests that these signals influence the differentiation pathway of mesenchymal stem cells (MSCs)...
  41. Enhancing Energy Expending Adipocytes in White Adipose Tissue
    STEPHEN ROBERT FARMER; Fiscal Year: 2013
    ..and BMP7 have opposing effects on MRTF-A activity and the ability of these effectors to commit mesenchymal stem cells to an brown/beige adipogenic versus vascular lineage...
  42. Stem/progenitor cells of the chondrocyte and osteoblast lineage in vivo
    Noriaki Ono; Fiscal Year: 2013
    ..Specific Aim 2. Early cells early in the osteoblast lineage Osteoblast differentiation of "mesenchymal stem cells" is regulated by transcription factors Runx2 and Osterix (Osx) expressed early after commitment to the ..
  43. East African Cichlids: A Natural Model for Dental Regeneration
    RYAN FREDRIC BLOOMQUIST; Fiscal Year: 2013
    ..With a more global health impact, we seek to identify the epithelial and mesenchymal stem cells responsible for the natural replacement of an adult organ...
  44. Smooth Muscle Differentiation and Maturation
    Shiyou Chen; Fiscal Year: 2013
    ..that RGC-32 is required for TGF-2-induced SMC differentiation from human embryonic stem cell- derived mesenchymal stem cells (huMSC). Moreover, RGC-32 appears to be important for both SMC differentiation and maturation...
  45. Technology platform for development of multi-component preservation solution
    Allison Hubel; Fiscal Year: 2013
    ..Of all of the cells therapies currently in development, mesenchymal stem cells (MSCs) appear to have the greatest diversity of applications and potential for widespread use...
  46. Role of Angiogenic CXC Chemokines in Intramembranous Bone Repair
    Dean T Yamaguchi; Fiscal Year: 2013
    ..of bone blood supply initiate a cascade of events to repair disrupted bone given the circumstances that mesenchymal stem cells (MSCs) can differentiate into osteoblasts (OBs) and that new blood supply can be re-established...
  47. Manipulation of beta-catenin signaling in adult oral cells for tooth regeneration
    Sarah E Millar; Fiscal Year: 2010
    ..While adult mesenchymal stem cells can participate in tooth bud formation, a suitable source of adult epithelial cells has not been ..
  48. Mesenchymal Stem Cells To Mitigate and Treat Cutaneous Injury Following Radiation
    William H McBride; Fiscal Year: 2010
    ..e. to be mesenchymal stem cells (MSCs)...
  49. Processing and Preservation of Human Umbilical Cord Stem Cells for Cell Therapeut
    Alfred Bahnson; Fiscal Year: 2010
    ..This project will study how to maximize the stocks of these cells and ensure their safe use in cell therapy. ..
  50. Molecular Regulation of Human Dental Stem Cell Properties
    Cun Yu Wang; Fiscal Year: 2013
    ..precursor populations isolated from dental tissues based on the primary characteristics of bone marrow mesenchymal stem cells (MSCs). Like bone marrow MSCs, dental stem cells are self-renewing, multipotent, and clonogenic...
  51. Bone Marrow Adiposity, Bone and Body Composition
    Ann V Schwartz; Fiscal Year: 2012
    ..A better understanding of the process underlying the accumulation of marrow fat with age and osteoporosis may provide new targets for treatments to prevent bone loss. ..
  52. INTERPLAYS BETWEEN THE JAW MESENCHYMAL STEM CELLS AND T LYMPHOCYTES
    Yufang Shi; Fiscal Year: 2010
    Bone marrow mesenchymal stem cells (BMMSCs) are multipotent stem cells capable of differentiating into different lineage cells including osteoblasts, chondrocytes, adipocytes, cardiomyocytes, myoblasts, and neural cells...
  53. Role of EGFR signaling in bone formation and the anabolic actions of PTH
    Ling Qin; Fiscal Year: 2013
    ..Osteoblasts are derived from mesenchymal progenitors, including mesenchymal stem cells (MSCs) and committed osteoprogenitors...
  54. Islet and Mesenchymal Stem Cell Co-transplantation Prevents Onset of Diabetes
    Hongjun Wang; Fiscal Year: 2013
    ..An ever-increasing body of literature demonstrates that transplantation of islets together with mesenchymal stem cells (MSCs) enhances islet engraftment, decreases number of islets needed to achieve normoglycemia by promoting ..
  55. Genetics of Osteoblast Differentiation
    Matthew Aaron Hibbs; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The proper development of mature, functional osteoblasts from mesenchymal stem cells (MSCs) is critical to the bone health of millions of Americans suffering from osteoporosis...
  56. Environmental PPAR Agonists Accelerate Aging of Bone and Impair Lymphopoiesis
    AMELIA RACHEL HAAS BAKER; Fiscal Year: 2013
    ..abstract_text> ..
  57. Adipogenic Toxicity Study of Obesogenic Drugs
    Yuanxiang Zhao; Fiscal Year: 2013
    ..of predominantly adipocytes (fat cells), in addition to preadipocytes (precursors of adipocytes), human mesenchymal stem cells (hMSCs) and a few other cell types including macrophages and endothelial cells...
  58. Role of Angiogenesis in Distraction Osteogenesis
    LOUIS CHARLES GERSTENFELD; Fiscal Year: 2013
    ..The completion of Aims 1 and 2 will determine if ECs are a primary cell source of BMP2 in regulating skeletal healing after surgery or injury and if BMP2 has a functional role in vasculogenesis. ..
  59. High Resolution Peripheral Quantitative CT
    MARY BETH LEONARD; Fiscal Year: 2013
    ..We have a detailed and ready-to-execute plan for operation that includes technical expertise and support, and full institutional commitment. ..
  60. Infarct Repair with Mesenchymal Stem Cell Subpopulation
    Buddhadeb Dawn; Fiscal Year: 2013
    ....
  61. A Novel Approach for Biomaterials Assisted Regeneration of Pulp-Dentin Complex
    Satish Alapati; Fiscal Year: 2013
    ..medicine, (c) molecular mechanisms and gene function in tooth development, (d) dental pulp stem cells and mesenchymal stem cells, and (e) dentin matrix proteins involved in biomineralization will ensure the PI's success as an ..
  62. Multicenter Cartilage Repair Preclinical Trial in Horses
    Constance R Chu; Fiscal Year: 2010
    ..ficoll density gradient centrifugation and culture expansion of what has been classically described as mesenchymal stem cells (MSC). Both strategies will be studied for one year in an equine cartilage injury model...
  63. Directing Stem Cell Differentiation on Biologically Inspired Micropatterned Surfa
    Anita Shukla; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Human mesenchymal stem cells (hMSCs) are of great interest as a multipotent autologous cell source that have shown promise in the treatment of a variety of diseases, including osteogenesis imperfecta ..
  64. Correction of neural abnormalities in Hurler syndrome
    Pankaj Gupta; Fiscal Year: 2003
    ....
  65. Imaging evidence: Is there competition between marrow fat and bone?
    Wei Shen; Fiscal Year: 2010
    ..Recent studies suggest that adipocytes in bone marrow and osteoblasts share the same precursor, mesenchymal stem cells (MSC). Human imaging studies [i.e...
  66. Synergistic effects of conjugated linoleic acid and calcium on bone mass
    Yeonhwa Park; Fiscal Year: 2009
    ..role of CLA specifically on balancing adipogenesis and osteogenesis due to the pluripotential nature of mesenchymal stem cells will help understand the critical aspects of CLA in regard to application for eventual use in human health...
  67. Matrix-induced Myogenesis & Pharmaco-Screens of MSCs
    Dennis Discher; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Matrix-induced Myogenesis &Pharmaco-Screens of MSCs Mesenchymal Stem Cells (MSC) are capable of differentiating into many tissue lineages, including muscle, leading to the belief that such cells ..
  68. Self Assembly of Cartilage by Mesenchymal Stem Cells on Porous Chitosan/CaP
    STEVEN HOWARD ELDER; Fiscal Year: 2010
    ..of porous chitosan/calcium phosphate and hyaline cartilage, the cartilage having been produced by mesenchymal stem cells (MSCs) attached to and piled atop the scaffold...
  69. Mechanisms of Testosterone Effects on Body Composition
    Shalendar Bhasin; Fiscal Year: 2007
    ..dihydrotestosterone (DHT), two prototypical androgens, promote the differentiation of adult, pluripotent mesenchymal stem cells into myogenic lineage and inhibit the differentiation of these cells into adipogenic lineage through an ..
  70. Mesenchymal Stem Cells for Myocardial Infarction
    Robert Kloner; Fiscal Year: 2006
    ..In this protocol we are proposing to use a commercial source of allogeneic rat mesenchymal stem cells (MSC)...
  71. Mechanisms of HAART-Induced Endothelial Dysfunction
    Krishna Agrawal; Fiscal Year: 2006
    ..These studies should provide evidence in support of our hypotheses that disruption of NO production by HAART results in endothelial dysfunction, which is further exacerbated in the presence of TNFalpha and/or Tat protein. ..
  72. Stem Cell-Driven Regeneration of the Mandibular Joint
    Jeremy Mao; Fiscal Year: 2006
    ..of the present proposal is to regenerate the mandibular condyle of the temporomandibular joint using mesenchymal stem cells seeded in biocompatible polymers...
  73. Matrix Metalloproteases Regulate Mesenchymal Stem Cells
    Zena Werb; Fiscal Year: 2006
    ..includes niches for fostering stem cells for several lineages including hematopoietic stem cells (HSC) and mesenchymal stem cells (MSC). Skeletal stem cells appear to be derived in part from the stromal component of the bone marrow...
  74. Regulated Osteochondrogenesis of Human Mesenchymal Stem Cells Using Gene Delivery
    Antonios Mikos; Fiscal Year: 2009
    ..construct presenting spatially controlled chondrogenic and osteogenic properties and generated from human mesenchymal stem cells (hMSCs)...
  75. Cell-Based Therapy for Dystrophic Epidermolysis Bullosa
    Olga Igoucheva; Fiscal Year: 2009
    ..Bone marrow contains mesenchymal progenitor cells, called mesenchymal stem cells (MSC), that have several unique properties suggesting the feasibility of their use as a therapeutic ..
  76. Targeting bone homing of the MSCs to augment bone formation
    Wei Yao; Fiscal Year: 2010
    ..A decrease in the number of mesenchymal stem cells (MSCs) in bone marrow with aging leads to reduced osteogenesis and thus reduces bone formation and ..