stem cells

Summary

Summary: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.

Top Publications

  1. pmc Control of developmental regulators by Polycomb in human embryonic stem cells
    Tong Ihn Lee
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 125:301-13. 2006
  2. ncbi A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    Bradley E Bernstein
    Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Cell 125:315-26. 2006
  3. ncbi Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    N Ferrara
    Department of Cardiovascular Research, Genentech Inc, South San Francisco, California 94080, USA
    Nature 380:439-42. 1996
  4. ncbi Identification of stem cells in small intestine and colon by marker gene Lgr5
    Nick Barker
    Hubrecht Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Nature 449:1003-7. 2007
  5. ncbi Marrow stromal cells as stem cells for nonhematopoietic tissues
    D J Prockop
    Center for Gene Therapy, Allegheny University of the Health Sciences, MCP Hahnemann School of Medicine, 245 North 15 Street, Mail Stop 421, Philadelphia, PA 19102, USA
    Science 276:71-4. 1997
  6. ncbi Multilineage potential of adult human mesenchymal stem cells
    M F Pittenger
    Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231 3043, USA
    Science 284:143-7. 1999
  7. ncbi Stem cells, cancer, and cancer stem cells
    T Reya
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Palo Alto, California 94305, USA
    Nature 414:105-11. 2001
  8. pmc The epithelial-mesenchymal transition generates cells with properties of stem cells
    Sendurai A Mani
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 133:704-15. 2008
  9. ncbi Multilineage cells from human adipose tissue: implications for cell-based therapies
    P A Zuk
    Laboratory for Regenerative Bioengineering and Repair, UCLA School of Medicine, Los Angeles, California, USA
    Tissue Eng 7:211-28. 2001
  10. ncbi Pluripotency of mesenchymal stem cells derived from adult marrow
    Yuehua Jiang
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 418:41-9. 2002

Detail Information

Publications347 found, 100 shown here

  1. pmc Control of developmental regulators by Polycomb in human embryonic stem cells
    Tong Ihn Lee
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 125:301-13. 2006
    ..These results indicate that PRC2 occupies a special set of developmental genes in ES cells that must be repressed to maintain pluripotency and that are poised for activation during ES cell differentiation...
  2. ncbi A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    Bradley E Bernstein
    Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Cell 125:315-26. 2006
    ..These results highlight the importance of DNA sequence in defining the initial epigenetic landscape and suggest a novel chromatin-based mechanism for maintaining pluripotency...
  3. ncbi Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    N Ferrara
    Department of Cardiovascular Research, Genentech Inc, South San Francisco, California 94080, USA
    Nature 380:439-42. 1996
    ..To assess the role of VEGF directly, we disrupted the VEGF gene in embryonic stem cells. Here we report the unexpected finding that loss of a single VEGF allele is lethal in the mouse embryo between ..
  4. ncbi Identification of stem cells in small intestine and colon by marker gene Lgr5
    Nick Barker
    Hubrecht Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Nature 449:1003-7. 2007
    ..It is currently believed that four to six crypt stem cells reside at the +4 position immediately above the Paneth cells in the small intestine; colon stem cells remain ..
  5. ncbi Marrow stromal cells as stem cells for nonhematopoietic tissues
    D J Prockop
    Center for Gene Therapy, Allegheny University of the Health Sciences, MCP Hahnemann School of Medicine, 245 North 15 Street, Mail Stop 421, Philadelphia, PA 19102, USA
    Science 276:71-4. 1997
    ..The cells have many of the characteristics of stem cells for tissues that can roughly be defined as mesenchymal, because they can be differentiated in culture into ..
  6. ncbi Multilineage potential of adult human mesenchymal stem cells
    M F Pittenger
    Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231 3043, USA
    Science 284:143-7. 1999
    Human mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including ..
  7. ncbi Stem cells, cancer, and cancer stem cells
    T Reya
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Palo Alto, California 94305, USA
    Nature 414:105-11. 2001
    Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their ..
  8. pmc The epithelial-mesenchymal transition generates cells with properties of stem cells
    Sendurai A Mani
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 133:704-15. 2008
    ..that those cells have an increased ability to form mammospheres, a property associated with mammary epithelial stem cells. Independent of this, stem cell-like cells isolated from HMLE cultures form mammospheres and express markers ..
  9. ncbi Multilineage cells from human adipose tissue: implications for cell-based therapies
    P A Zuk
    Laboratory for Regenerative Bioengineering and Repair, UCLA School of Medicine, Los Angeles, California, USA
    Tissue Eng 7:211-28. 2001
    Future cell-based therapies such as tissue engineering will benefit from a source of autologous pluripotent stem cells. For mesodermal tissue engineering, one such source of cells is the bone marrow stroma...
  10. ncbi Pluripotency of mesenchymal stem cells derived from adult marrow
    Yuehua Jiang
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 418:41-9. 2002
    We report here that cells co-purifying with mesenchymal stem cells--termed here multipotent adult progenitor cells or MAPCs--differentiate, at the single cell level, not only into mesenchymal cells, but also cells with visceral mesoderm, ..
  11. doi Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells
    Hugo J Snippert
    Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Cell 143:134-44. 2010
    Intestinal stem cells, characterized by high Lgr5 expression, reside between Paneth cells at the small intestinal crypt base and divide every day...
  12. pmc Phenotypic characterization of human colorectal cancer stem cells
    Piero Dalerba
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 104:10158-63. 2007
    ..These results validate the stem cell working model in human CRC and provide a highly robust surface marker profile for CRC stem cell isolation...
  13. ncbi SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
    To improve our ability to identify hematopoietic stem cells (HSCs) and their localization in vivo, we compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors (MPPs)...
  14. pmc Eyes wide open: a critical review of sphere-formation as an assay for stem cells
    Erika Pastrana
    Departments of Pathology and Cell Biology, Neurology, and Neuroscience, Columbia Stem Cell Initiative, Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, NY 10032, USA
    Cell Stem Cell 8:486-98. 2011
    Sphere-forming assays have been widely used to retrospectively identify stem cells based on their reported capacity to evaluate self-renewal and differentiation at the single-cell level in vitro...
  15. doi Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    Toshiro Sato
    Hubrecht Institute and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Nature 459:262-5. 2009
    ..We have recently demonstrated the presence of about six cycling Lgr5(+) stem cells at the bottoms of small-intestinal crypts...
  16. pmc The glial nature of embryonic and adult neural stem cells
    Arnold Kriegstein
    The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Neurology, University of California, San Francisco, California 94143 0525, USA
    Annu Rev Neurosci 32:149-84. 2009
    ..and specific subpopulations of astrocytes in adult mammals--function as primary progenitors or neural stem cells (NSCs)...
  17. ncbi Circulating endothelial progenitor cells, vascular function, and cardiovascular risk
    Jonathan M Hill
    Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1622, USA
    N Engl J Med 348:593-600. 2003
    ....
  18. ncbi BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3
    Qi Long Ying
    Institute for Stem Cell Research, University of Edinburgh, King s Buildings, West Mains Road, EH9 3JQ, Edinburgh, Scotland
    Cell 115:281-92. 2003
    ..Upon LIF withdrawal, Id-expressing ES cells differentiate but do not give rise to neural lineages. We conclude that blockade of lineage-specific transcription factors by Id proteins enables the self-renewal response to LIF/STAT3...
  19. doi Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
    Danwei Huangfu
    Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Biotechnol 26:795-7. 2008
    ..VPA also enables efficient induction of pluripotent stem cells without introduction of the oncogene c-Myc.
  20. ncbi Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    E Li
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Cell 69:915-26. 1992
    ....
  21. ncbi Embryonic stem cell lines derived from human blastocysts
    J A Thomson
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
    Science 282:1145-7. 1998
    ..express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages...
  22. pmc Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells
    Yohei Shimono
    Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 1050 Arastradero Road, Palo Alto, CA 94304, USA
    Cell 138:592-603. 2009
    Human breast tumors contain a breast cancer stem cell (BCSC) population with properties reminiscent of normal stem cells. We found 37 microRNAs that were differentially expressed between human BCSCs and nontumorigenic cancer cells...
  23. ncbi Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
    Daniel J Ceradini
    Laboratory of Microvascular Research and Vascular Tissue Engineering, Institute of Reconstructive Plastic Surgery, New York University School of Medicine, New York, New York 10016, USA
    Nat Med 10:858-64. 2004
    ..The chemokine stromal cell-derived factor-1 (SDF-1 or CXCL12) mediates homing of stem cells to bone marrow by binding to CXCR4 on circulating cells...
  24. doi Wnt signaling in stem and cancer stem cells
    Jane D Holland
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, D 13125 Berlin, Germany
    Curr Opin Cell Biol 25:254-64. 2013
    The functional versatility of Wnt/β-catenin signaling can be seen by its ability to act in stem cells of the embryo and of the adult as well as in cancer stem cells...
  25. pmc Human adipose tissue is a source of multipotent stem cells
    Patricia A Zuk
    Department of Surgery and Orthopedics, Regenerative Bioengineering and Repair Laboratory, UCLA School of Medicine, Los Angeles, California 90095, USA
    Mol Biol Cell 13:4279-95. 2002
    Much of the work conducted on adult stem cells has focused on mesenchymal stem cells (MSCs) found within the bone marrow stroma...
  26. pmc CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors
    Sergey V Shmelkov
    Howard Hughes Medical Institute, Ansary Center for Stem Cell Therapeutics, and Department of Genetic Medicine, Weill Medical College of Cornell University, New York, New York, USA
    J Clin Invest 118:2111-20. 2008
    Colon cancer stem cells are believed to originate from a rare population of putative CD133+ intestinal stem cells...
  27. ncbi Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties
    Dario Ponti
    Department of Experimental Oncology and Laboratories, Istituto Nazionale Tumori, Milan, Italy
    Cancer Res 65:5506-11. 2005
    ....
  28. pmc A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
    Hua Tian
    Department of Molecular Biology, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 478:255-9. 2011
    ..of Lgr5-expressing cells, progeny production by Bmi1-expressing cells increased, indicating that Bmi1-expressing stem cells compensate for the loss of Lgr5-expressing cells...
  29. ncbi Neuronal replacement from endogenous precursors in the adult brain after stroke
    Andreas Arvidsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
    Nat Med 8:963-70. 2002
    ..If the new neurons are functional and their formation can be stimulated, a novel therapeutic strategy might be developed for stroke in humans...
  30. ncbi Directed differentiation of embryonic stem cells into motor neurons
    Hynek Wichterle
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Cell 110:385-97. 2002
    ..have been identified, raising the question of whether these developmental insights can be used to direct stem cells to a motor neuron fate...
  31. ncbi The cell biology of neurogenesis
    Magdalena Gotz
    Institute for Stem Cell Research, GSF National Research Center for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg Munich, Germany
    Nat Rev Mol Cell Biol 6:777-88. 2005
    During the development of the mammalian central nervous system, neural stem cells and their derivative progenitor cells generate neurons by asymmetric and symmetric divisions...
  32. doi Stem cells, self-renewal, and differentiation in the intestinal epithelium
    Laurens G van der Flier
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT, Utrecht, The Netherlands
    Annu Rev Physiol 71:241-60. 2009
    ..The intestine is composed of proliferative crypts, which contain intestinal stem cells, and villi, which contain differentiated specialized cell types...
  33. pmc In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 17:1253-70. 2003
    Although the existence of mammary stem cells has been suggested by serial transplantation studies in mice, their identification has been hindered by the lack of specific surface markers, and by the absence of suitable in vitro assays for ..
  34. ncbi Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
    T Asahara
    Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Circ Res 85:221-8. 1999
    ....
  35. pmc Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature
    Emmanuelle Charafe-Jauffret
    Centre de Recherche en Cancerologie de Marseille, Laboratoire d Oncologie Moleculaire, UMR891 Inserm Institut Paoli Calmettes, Universite de la Mediterranee, Marseille, France
    Cancer Res 69:1302-13. 2009
    ....
  36. ncbi Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart
    Catalin Toma
    Department of Medicine, Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Circulation 105:93-8. 2002
    ..We investigated the potential of human mesenchymal stem cells (hMSCs) from adult bone marrow to undergo myogenic differentiation once transplanted into the adult murine ..
  37. pmc Stem cells and niches: mechanisms that promote stem cell maintenance throughout life
    Sean J Morrison
    Howard Hughes Medical Institute, Life Sciences Institute, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI, 48109 2216, USA
    Cell 132:598-611. 2008
    Niches are local tissue microenvironments that maintain and regulate stem cells. Long-predicted from mammalian studies, these structures have recently been characterized within several invertebrate tissues using methods that reliably ..
  38. pmc Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells
    Jose M Polo
    Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School, Cambridge, Massachusetts, USA
    Nat Biotechnol 28:848-55. 2010
    Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors...
  39. pmc Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer
    Andrew E Teschendorff
    University College London, London WC1E 6BT, UK
    Genome Res 20:440-6. 2010
    ..These findings shed substantial novel insights into the epigenetic effects of aging and support the view that age may predispose to malignant transformation by irreversibly stabilizing stem cell features...
  40. ncbi Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood
    David A Ingram
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 104:2752-60. 2004
    ....
  41. ncbi Circulating endothelial progenitor cells and cardiovascular outcomes
    Nikos Werner
    Division of Cardiology, Angiology, and Intensive Care Medicine, Department of Internal Medicine, University of Saarland, Homburg Saar, Germany
    N Engl J Med 353:999-1007. 2005
    ..The number and function of endothelial progenitor cells correlate inversely with cardiovascular risk factors, but the prognostic value associated with circulating endothelial progenitor cells has not been defined...
  42. ncbi Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment
    Rowena McBeath
    The Cellular and Molecular Medicine Program, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 6:483-95. 2004
    Commitment of stem cells to different lineages is regulated by many cues in the local tissue microenvironment...
  43. pmc Growth factors, matrices, and forces combine and control stem cells
    Dennis E Discher
    Biophysical Engineering and Nanobiopolymers Laboratory, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 324:1673-7. 2009
    ..extracellular matrices define a local biochemical and mechanical niche with complex and dynamic regulation that stem cells sense...
  44. ncbi Cancer stem cells
    Craig T Jordan
    James P Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, NY 14642, USA
    N Engl J Med 355:1253-61. 2006
  45. ncbi Wnt signalling regulates adult hippocampal neurogenesis
    Dieter Chichung Lie
    Laboratory of Genetics, The Salk Institute, La Jolla, California 92037, USA
    Nature 437:1370-5. 2005
    The generation of new neurons from neural stem cells is restricted to two regions of the adult mammalian central nervous system: the subventricular zone of the lateral ventricle, and the subgranular zone of the hippocampal dentate gyrus...
  46. doi Distinct contribution of stem and progenitor cells to epidermal maintenance
    Guilhem Mascre
    Universite Libre de Bruxelles, IRIBHM, Brussels B 1070, Belgium
    Nature 489:257-62. 2012
    ..One posits that IFE is maintained by long-lived slow-cycling stem cells that give rise to transit-amplifying cell progeny, whereas the other suggests that homeostasis is achieved by a ..
  47. ncbi Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
    F Shalaby
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nature 376:62-6. 1995
    ..These results indicate that Flk-1 is essential for yolk-sac blood-island formation and vasculogenesis in the mouse embryo...
  48. ncbi Adult neurogenesis in the mammalian central nervous system
    Guo li Ming
    Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Annu Rev Neurosci 28:223-50. 2005
    ..Advances in our understanding of adult neurogenesis will not only shed light on the basic principles of adult plasticity, but also may lead to strategies for cell replacement therapy after injury or degenerative neurological diseases...
  49. ncbi Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo
    Amelia Bartholomew
    University of Illinois, Chicago 60607, USA
    Exp Hematol 30:42-8. 2002
    Mesenchymal stem cells (MSCs), multipotential cells that reside within the bone marrow, can be induced to differentiate into various components of the marrow microenvironment, such as bone, adipose, and stromal tissues...
  50. pmc Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals
    Mervin C Yoder
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 109:1801-9. 2007
    ..Thus, these studies establish that CFU-ECs are not EPCs and the role of these cells in angiogenesis must be re-examined prior to further clinical trials, whereas ECFCs may serve as a potential therapy for vascular regeneration...
  51. pmc Generation of breast cancer stem cells through epithelial-mesenchymal transition
    Anne Pierre Morel
    Centre Leon Berard, Lyon, France
    PLoS ONE 3:e2888. 2008
    Recently, two novel concepts have emerged in cancer biology: the role of so-called "cancer stem cells" in tumor initiation, and the involvement of an epithelial-mesenchymal transition (EMT) in the metastatic dissemination of epithelial ..
  52. ncbi Derivation of embryonic stem-cell lines from human blastocysts
    Chad A Cowan
    Howard Hughes Medical Institute, Cambridge, Mass, USA
    N Engl J Med 350:1353-6. 2004
  53. pmc Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture
    P M Gilbert
    Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 329:1078-81. 2010
    b>Stem cells that naturally reside in adult tissues, such as muscle stem cells (MuSCs), exhibit robust regenerative capacity in vivo that is rapidly lost in culture...
  54. ncbi Identification of human brain tumour initiating cells
    Sheila K Singh
    The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children and University of Toronto, 555 University Avenue, Toronto, M5G 1X8, Canada
    Nature 432:396-401. 2004
    ....
  55. ncbi Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures
    Oren M Tepper
    Laboratory of Microvascular Research and Vascular Tissue Engineering, Institute of Reconstructive Plastic Surgery, New York University Medical Center, New York, NY 10016, USA
    Circulation 106:2781-6. 2002
    ..Because diabetic complications occur in conditions in which EPC contributions have been demonstrated, EPC dysfunction may be important in their pathophysiology...
  56. pmc Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
    Zhizhong Li
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 15:501-13. 2009
    Glioblastomas are lethal cancers characterized by florid angiogenesis promoted in part by glioma stem cells (GSCs). Because hypoxia regulates angiogenesis, we examined hypoxic responses in GSCs...
  57. pmc Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells
    Derk ten Berge
    Erasmus MC Stem Cell Institute, Department of Cell Biology, Erasmus Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Nat Cell Biol 13:1070-5. 2011
    Pluripotent stem cells exist in naive and primed states, epitomized by mouse embryonic stem cells (ESCs) and the developmentally more advanced epiblast stem cells (EpiSCs; ref. 1)...
  58. pmc Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells
    N Mizushima
    Unit Process and Combined Circuit, PRESTO, Japan Science and Technology Corporation, Kawaguchi 332 0012, Japan
    J Cell Biol 152:657-68. 2001
    ..Here we show that mouse Apg12-Apg5 conjugate localizes to the isolation membranes in mouse embryonic stem cells. Using green fluorescent protein-tagged Apg5, we revealed that the cup-shaped isolation membrane is developed ..
  59. pmc Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs
    Federica Collino
    Department of Internal Medicine and Center for Molecular Biotechnology, University of Torino, Torino, Italy
    PLoS ONE 5:e11803. 2010
    ..Human bone marrow derived mesenchymal stem cells (MSCs) and liver resident stem cells (HLSCs) were shown to release MVs shuttling functional mRNAs...
  60. doi Distinct stem cells contribute to mammary gland development and maintenance
    Alexandra Van Keymeulen
    Universite Libre de Bruxelles, IRIBHM, Brussels B 1070, Belgium
    Nature 479:189-93. 2011
    ..studies have suggested that the mammary epithelium is maintained by the presence of multipotent mammary stem cells. To define the cellular hierarchy of the mammary gland during physiological conditions, we performed genetic ..
  61. ncbi Wnt signalling in stem cells and cancer
    Tannishtha Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 434:843-50. 2005
    The canonical Wnt cascade has emerged as a critical regulator of stem cells. In many tissues, activation of Wnt signalling has also been associated with cancer...
  62. ncbi DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    M Okano
    Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown 02129, USA
    Cell 99:247-57. 1999
    ..Our results indicate that both Dnmt3a and Dnmt3b function as de novo methyltransferases that play important roles in normal development and disease...
  63. ncbi Mesenchymal progenitor cells in human umbilical cord blood
    A Erices
    Unidad de Biologia Celular, INTA, Universidad de Chile, Santiago, Chile
    Br J Haematol 109:235-42. 2000
    ..Our results suggest that preterm, as compared with term, cord blood is richer in mesenchymal progenitors, similar to haematopoietic progenitors...
  64. pmc The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor
    Anne E Powell
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cell 149:146-58. 2012
    Lineage mapping has identified both proliferative and quiescent intestinal stem cells, but the molecular circuitry controlling stem cell quiescence is incompletely understood...
  65. ncbi Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
    Manuel Alvarez-Dolado
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143 0520, USA
    Nature 425:968-73. 2003
    ..These observations provide the first in vivo evidence for cell fusion of BMDCs with neurons and cardiomyocytes, raising the possibility that cell fusion may contribute to the development or maintenance of these key cell types...
  66. doi Mechanisms of asymmetric stem cell division
    Juergen A Knoblich
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Cell 132:583-97. 2008
    b>Stem cells self-renew but also give rise to daughter cells that are committed to lineage-specific differentiation...
  67. ncbi Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
    H Niwa
    Centre for Genome Research, The University of Edinburgh, King s Buildings, Edinburgh, UK
    Nat Genet 24:372-6. 2000
    ....
  68. pmc Core transcriptional regulatory circuitry in human embryonic stem cells
    Laurie A Boyer
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 122:947-56. 2005
    ..These results provide new insights into the transcriptional regulation of stem cells and reveal how OCT4, SOX2, and NANOG contribute to pluripotency and self-renewal.
  69. ncbi For the long run: maintaining germinal niches in the adult brain
    Arturo Alvarez-Buylla
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143 USA
    Neuron 41:683-6. 2004
    The adult mammalian brain retains neural stem cells that continually generate new neurons within two restricted regions: the subventricular zone (SVZ) of the lateral ventricle and the dentate gyrus subgranular zone (SGZ) of the ..
  70. ncbi In vitro differentiation of transplantable neural precursors from human embryonic stem cells
    S C Zhang
    Department of Anatomy, University of Wisconsin 1500 Highland Avenue, Madison, WI 53705, USA
    Nat Biotechnol 19:1129-33. 2001
    ..No teratoma formation was observed in the transplant recipients. These results depict human ES cells as a source of transplantable neural precursors for possible nervous system repair...
  71. ncbi Inflammatory blockade restores adult hippocampal neurogenesis
    Michelle L Monje
    Stanford University, Department of Neurosurgery, MSLS P309, Mail Code 5487, 1201 Welch Road, Stanford, CA 94305 5487, USA
    Science 302:1760-5. 2003
    ....
  72. ncbi Angiogenesis in health and disease
    Peter Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
    Nat Med 9:653-60. 2003
    ..Molecular insights into these processes are being generated at a rapidly increasing pace, offering new therapeutic opportunities that are currently being evaluated...
  73. ncbi Molecular definition of breast tumor heterogeneity
    Michail Shipitsin
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Cell 11:259-73. 2007
    ..Our data suggest prognostic relevance of CD44+ cells and therapeutic targeting of distinct tumor cell populations...
  74. doi Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators
    Nicola K Wilson
    University of Cambridge Department of Haematology, Cambridge Institute for Medical Research, Hills Road, Cambridge, CB2 0XY, UK
    Cell Stem Cell 7:532-44. 2010
    ..Taken together, this study demonstrates the power of genome-wide analysis in generating novel functional insights into the transcriptional control of stem and progenitor cells...
  75. ncbi Mammalian neural stem cells
    F H Gage
    The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 287:1433-8. 2000
    Neural stem cells exist not only in the developing mammalian nervous system but also in the adult nervous system of all mammalian organisms, including humans. Neural stem cells can also be derived from more primitive embryonic stem cells...
  76. pmc Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo
    S Gronthos
    Craniofacial and Skeletal Diseases Branch, National Institute on Dental Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:13625-30. 2000
    ..This study isolates postnatal human DPSCs that have the ability to form a dentin/pulp-like complex...
  77. doi Wound repair and regeneration
    Geoffrey C Gurtner
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 257 Campus Drive, Stanford, California 94305 5148, USA
    Nature 453:314-21. 2008
    ..Knowledge gained from studying such organisms might help to unlock latent regenerative pathways in humans, which would change medical practice as much as the introduction of antibiotics did in the twentieth century...
  78. pmc Dedifferentiation of committed epithelial cells into stem cells in vivo
    Purushothama Rao Tata
    1 Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA 2 Departments of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts 02114, USA 3 Department of Internal Medicine, Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA 4 Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA
    Nature 503:218-23. 2013
    ..differentiated cells are known to revert into replicating progenitors, but these cells do not persist as stable stem cells. Here we present evidence that differentiated airway epithelial cells can revert into stable and functional stem ..
  79. pmc Dll1+ secretory progenitor cells revert to stem cells upon crypt damage
    Johan H van Es
    Hubrecht Institute for Developmental Biology and Stem Cell Research and Univerity Medical Centre Utrecht, Utrecht, Netherlands
    Nat Cell Biol 14:1099-104. 2012
    Lgr5+ intestinal stem cells generate enterocytes and secretory cells. Secretory lineage commitment requires Notch silencing. The Notch ligand Dll1 is expressed by a subset of immediate stem cell daughters...
  80. doi DNA damage checkpoints in stem cells, ageing and cancer
    Tobias Sperka
    Leibniz Institute for Age Research Fritz Lipmann Institute, Beutenbergstr 11, 07745 Jena, Germany
    Nat Rev Mol Cell Biol 13:579-90. 2012
    ..The outcome depends on cell-intrinsic and cell-extrinsic mechanisms that regulate the clearance of damaged cells and on the molecular context in ageing tissues, including the level of DNA damage accumulation itself...
  81. pmc Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury
    Osahiko Tsuji
    Department of Physiology, School of Medicine, Keio University, Shinjuku, Tokyo 160 8582, Japan
    Proc Natl Acad Sci U S A 107:12704-9. 2010
    ..These findings suggest that pre-evaluated safe iPS clone-derived neural stem/progenitor cells may be a promising cell source for transplantation therapy for SCI...
  82. pmc Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis
    Emina H Huang
    Department of Surgery, University of Florida, Gainesville, Florida, USA
    Cancer Res 69:3382-9. 2009
    Although the concept that cancers originate from stem cells (SC) is becoming scientifically accepted, mechanisms by which SC contribute to tumor initiation and progression are largely unknown...
  83. doi Mechanisms and functional implications of adult neurogenesis
    Chunmei Zhao
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell 132:645-60. 2008
    ..throughout adulthood in the mammalian brain due to the proliferation and differentiation of adult neural stem cells. In this review, we discuss the factors that regulate proliferation and fate determination of adult neural stem ..
  84. pmc The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine
    Paolo Bianco
    Department of Molecular Medicine, La Sapienza Universita di Roma, Rome, Italy
    Nat Med 19:35-42. 2013
    Mesenchymal stem cells (MSCs) are the focus of intensive efforts worldwide directed not only at elucidating their nature and unique properties but also developing cell-based therapies for a diverse range of diseases...
  85. pmc Immunological applications of stem cells in type 1 diabetes
    Paolo Fiorina
    Transplantation Research Center, Division of Nephrology, Children s Hospital Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Endocr Rev 32:725-54. 2011
    ..Finally, embryonic SCs also offer exciting prospects because they are able to generate glucose-responsive insulin-producing cells. Easy enthusiasm should be mitigated mainly because of the potential oncogenicity of SCs...
  86. ncbi SOX2 functions to maintain neural progenitor identity
    Victoria Graham
    Neuroscience Center, Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    Neuron 39:749-65. 2003
    ..factors, including the three closely related genes Sox1, Sox2, and Sox3, universally mark neural progenitor and stem cells throughout the vertebrate CNS...
  87. ncbi Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering
    M P Lutolf
    Integrative Biosciences Institute, Ecole Polytechnique Federale de Lausanne EPFL, Building AA B 039, CH 1015 Lausanne, Switzerland
    Nat Biotechnol 23:47-55. 2005
    ..These materials have already found application in differentiating stem cells into neurons, repairing bone and inducing angiogenesis...
  88. ncbi p63 Is essential for the proliferative potential of stem cells in stratified epithelia
    Makoto Senoo
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 129:523-36. 2007
    The distinguishing feature of adult stem cells is their extraordinary capacity to divide prior to the onset of senescence...
  89. pmc Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma
    M E Prince
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 104:973-8. 2007
    ..original tumor heterogeneity and could be serially passaged, thus demonstrating the two defining properties of stem cells: ability to self-renew and to differentiate...
  90. pmc Telocytes and stem cells in limbus and uvea of mouse eye
    María José Luesma
    Department of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain
    J Cell Mol Med 17:1016-24. 2013
    ..The ultrastructural nanocontacts of TCs with SCs and the TCs paracrine influence via exosomes in the epithelial and stromal SC niches suggest an important participation of TCs in eye regeneration. ..
  91. doi Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland
    Renée van Amerongen
    Department of Developmental Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Cell Stem Cell 11:387-400. 2012
    The mammary epithelium undergoes extensive growth and remodeling during pregnancy, suggesting a role for stem cells. Yet their origin, identity, and behavior in the intact tissue remain unknown...
  92. pmc Linking functional decline of telomeres, mitochondria and stem cells during ageing
    Ergun Sahin
    Belfer Institute for Applied Cancer Science, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 464:520-8. 2010
    ..function and associated p53 activation have emerged as prime instigators of a functional decline of tissue stem cells and of mitochondrial dysfunction that adversely affect renewal and bioenergetic support in diverse tissues...
  93. pmc Telocytes and putative stem cells in the lungs: electron microscopy, electron tomography and laser scanning microscopy
    Laurentiu M Popescu
    Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    Cell Tissue Res 345:391-403. 2011
    ..At bronchoalveolar junctions, TCs have been observed in close association with putative stem cells (SCs) in the subepithelial stroma. SCs are recognized by their ultrastructure and Sca-1 positivity...
  94. pmc Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut
    Huaqi Jiang
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cell 137:1343-55. 2009
    ..Gut homeostasis is maintained by intestinal stem cells (ISCs) that divide to replenish the intestinal epithelium, but little is known about how ISC division and ..
  95. pmc Metabolic state of glioma stem cells and nontumorigenic cells
    Erina Vlashi
    Department of Radiation Oncology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 108:16062-7. 2011
    Gliomas contain a small number of treatment-resistant glioma stem cells (GSCs), and it is thought that tumor regrowth originates from GSCs, thus rendering GSCs an attractive target for novel treatment approaches...
  96. doi Oxygen in stem cell biology: a critical component of the stem cell niche
    Ahmed Mohyeldin
    Department of Neurosurgery and Oncology, Brain Tumor Stem Cell Laboratory, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Cell Stem Cell 7:150-61. 2010
    The defining hallmark of stem cells is their ability to self-renew and maintain multipotency. This capacity depends on the balance of complex signals in their microenvironment...
  97. pmc In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
    Meritxell Huch
    Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht, Netherlands
    Nature 494:247-50. 2013
    The Wnt target gene Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) marks actively dividing stem cells in Wnt-driven, self-renewing tissues such as small intestine and colon, stomach and hair follicles...
  98. pmc The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers
    Javier Munoz
    Bijvoet Center for Biomolecular Research, Utrecht Institute for Pharmaceutical Sciences, University, The Netherlands
    EMBO J 31:3079-91. 2012
    Two types of stem cells are currently defined in small intestinal crypts: cycling crypt base columnar (CBC) cells and quiescent '+4' cells...
  99. ncbi The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
    Yuin Han Loh
    Gene Regulation Laboratory, Genome Institute of Singapore, Singapore 138672
    Nat Genet 38:431-40. 2006
    ..The emerging picture is one in which Oct4 and Nanog control a cascade of pathways that are intricately connected to govern pluripotency, self-renewal, genome surveillance and cell fate determination...
  100. doi In Vivo differentiation potential of epiblast stem cells revealed by chimeric embryo formation
    Yali Huang
    MRC Centre for Regenerative Medicine, School of Biological Sciences, University of Edinburgh, Edinburgh bioQuarter, Edinburgh, UK
    Cell Rep 2:1571-8. 2012
    ..or morula aggregation is the principal functional assay of the developmental potential of mouse embryonic stem cells (ESCs)...
  101. ncbi Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    Akira Orimo
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 121:335-48. 2005
    ..Our findings indicate that fibroblasts within invasive breast carcinomas contribute to tumor promotion in large part through the secretion of SDF-1...

Research Grants122 found, 100 shown here

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..b>Stem cells from a donor's blood are used to replace the recipient's stem cells in the bone marrow...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..b>Stem cells from a donor's blood are used to replace the recipient's stem cells in the bone marrow...
  3. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Specific Challenge Topic 14-DK-101, "Induced Pluripotent stem cells-cellular and humanized mouse" Somatic cells such as fibroblasts from patients with diseases can be used to create cell lines, ..
  4. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..the GDNF receptor, Ret, and the EDN3 receptor Endothelin receptor B (EDNRB) are expressed by the neural crest stem cells (NCSCs) that give rise to the ENS ADDIN EN.CITE ADDIN EN.CITE.DATA [3] ...
  5. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..and developmental processes including angiogenesis, lymphocyte trafficking and the migration of hematopoietic stem cells, natural killer cells, and cancer cells...
  6. Enterococcus faecalis, Colorectal Cancer, and Bystander Effects
    Mark M Huycke; Fiscal Year: 2012
    ..triggered by redox-active commensal bacteria to produce bystander effects (BSE) that lead to CIN in crypt stem cells. The bystander effect refers to collateral DNA damage in neighboring cells from activated cells that produce ..
  7. Immunomodulatory and regenerative effects of mesenchymal stem cells on allografts
    Norma S Kenyon; Fiscal Year: 2013
    ..Furthermore, MSC administration may constitute a safe and effective way to reverse rejection episodes. ..
  8. Patient-Derived Stem Cells for Phosphoproteomic Profiling Neuropsychopathology
    Dieter A Wolf; Fiscal Year: 2011
    ..Recent advances have allowed the conversion of patient-specific human fibroblasts to human induced pluripotent stem cells (hIPSCs), cells which become sufficiently dedifferentiated to a primordial developmental stage that they now ..
  9. GENETIC ANALYSIS OF POLARITY
    RUTH M STEWARD; Fiscal Year: 2010
    ..The present model says that the lymphgland medulla contains stem cells that ultimately differentiate into three different hemocytes...
  10. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2012
    ..of EMT, NF-?B is required to orchestrate changes associated with the induction and maintenance of cancer stem cells. Cancer stem cells are believed to act as a "seed" which is able to reestablish malignant disease...
  11. Transgenesis and Xenotransplantation
    Jorge A Piedrahita; Fiscal Year: 2013
    ..Aim 2a. We will utilize human/or swine bone marrow hematopoietic stem cells (HSC) to repopulate the immune system by injecting into a developing fetus prior to immune maturation...
  12. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..develop human models of TS, I reprogrammed human skin cells from two TS patients to generate induced pluripotent stem cells (iPSCs) and differentiated these cells into CMs...
  13. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..develop human models of TS, I reprogrammed human skin cells from two TS patients to generate induced pluripotent stem cells (iPSCs) and differentiated these cells into CMs...
  14. Regulation of myocardial growth and death by GSK-3
    Junichi Sadoshima; Fiscal Year: 2013
    ..cardiac hypertrophy, ischemia/reperfusion (I/R) and differentiation of bone marrow (BM)-derived mesenchymal stem cells (MSCs) by focusing on novel connections between GSK-3 isoforms and their downstream targets...
  15. Twenty-second Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2010
    ..The disease is an ideal candidate for gene therapy because of the inherent selectability of complemented stem cells. Broad evidence is being developed that dysfunction of the FA signaling pathways can develop as somatic changes (..
  16. 24th Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2012
    ..The disease is an ideal candidate for gene therapy because of the inherent selectability of complemented stem cells. Broad evidence is being developed that dysfunction of the FA signaling pathways can result in somatic changes (..
  17. Targeting CC-Chemokine Receptor 7 for the prevention of graft-versus-host disease
    JAMES M COGHILL; Fiscal Year: 2013
    ..the administration of chemotherapy and/or radiation to patients, followed by the transplant of hematopoietic stem cells from a sibling or unrelated matched donor...
  18. Remote-control mouse-implantable micropumps for establishment of regenerative cap
    JUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010
    ..In adult mammals, muscle stem cells (MuSCs) proliferate less, there is less new muscle produced, and there is more fibrosis, than in young mammals...
  19. Chemical modulators of Tet-family proteins
    Anjana Rao; Fiscal Year: 2010
    ..TET proteins have been linked to cancer, and hmC is found at high levels in embryonic stem cells and certain classes of neuronal cells...
  20. Integrated signaling of eicosanoids in HSC formation and regeneration
    Trista E North; Fiscal Year: 2013
    ..In vertebrates, definitive hematopoietic stem cells (HSCs) produce each of the mature blood cell lineages of an individual throughout its lifetime...
  21. Molecular Mechanisms of Disease Progression in Myeloid Malignancy
    ELIZABETH ANN EKLUND; Fiscal Year: 2013
    ..Insensitivity of cancer/leukemia stem cells (CSC/LSC) to Fas-induced apoptosis is associated with development of drug resistance in CML, but does not ..
  22. Stem Cell Homing for Treatment of Female Pelvic Floor Disorders
    Margot S Damaser; Fiscal Year: 2013
    ..b>Stem cells participate in normal repair processes and have the potential to be harnessed as a preventative therapy to ..
  23. Identification of Proteins Important for Male Osteoporosis
    Hong Wen Deng; Fiscal Year: 2013
    ..Bone marrow mesenchymal stem cells (BMMSCs) and peripheral blood monocytes (PBMs) are precursors for osteoblasts (bone formation cells) and ..
  24. PTEN TUMOR SUPPRESSOR AND SIGNAL TRANSDUCTION
    RAMON E PARSONS; Fiscal Year: 2012
    ..Name Organization Role on Project Hibshoosh, Hanina Columbia University Collaborator Human Embryonic Stem Cells [X] No \_\ Yes If the proposed project involves human embryonic stem cells, list below the registration number ..
  25. CPG METHYLATION AND MUTATION
    Gerd P Pfeifer; Fiscal Year: 2013
    ..It has been hypothesized that the Polycomb repression complex present in stem cells at specific gene loci accelerates or facilitates recruitment of DNA methyltransferases and de novo methylation ..
  26. MECHANISMS OF EUKARYOTIC TRANSCRIPTIONAL REGULATION
    Michael R Green; Fiscal Year: 2013
    ..have found that alterations in the general transcription machinery may play an important role in human embryonic stem cells (hESCs)...
  27. VISUAL SCIENCES TRAINING PROGRAM
    Eric Pearlman; Fiscal Year: 2013
    ..VSTP Trainers listed in Table 2 OTHER SIGNIFICANT CONTRIBUTORS Name Organization Role on Project Human Embryonic Stem Cells ^ No [unreadable] Yes If the proposed project involves human embryonic stem cells, list below the registration ..
  28. Analysis of the role of the VRK1 protein kinase in mammalian fertility
    Paula Traktman; Fiscal Year: 2011
    ..VRK1 depletion leads to a cell-autonomous defect in the proliferation and/or differentiation of spermatogonial stem cells. We will also explore the alternative hypothesis that VRK1- deficient Sertoli cells cannot provide a niche that ..
  29. Improving Epigenetic-based Cell Reprogramming with Proteasome Inhibition
    Jaroslaw Staszkiewicz; Fiscal Year: 2011
    ..the possibility that alternative strategies could be developed on an industrial scale to produce pluripotent stem cells without using embryos or genetic manipulations...
  30. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    Thomas Ortel; Fiscal Year: 2010
    ..Consultant Duke University Consultant University of North Carolina, Consultant Chapel Hill Human Embryonic Stem Cells ^ No Q Yes If the proposed project involves human embryonic stem cells, list below the registration number of ..
  31. Pluripotent stem cell-derived HSCs: improvements and molecular mechanisms
    Patrick Cahan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hematopoietic stem cells (HSC), largely residing in the bone marrow of adult mammals, are the progenitors of all blood cells, including all myeloid and lymphoid lineages...
  32. Epigenetic Analysis of iPS Cell Models of Aging and Alzheimer's Disease
    Bruce A Yankner; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (14) Stem Cells, and specific Challenge Topic, 14-AG-101: Induced Pluripotent Stem (iPS) Cells for Aging and Neurodegeneration Research...
  33. Combined BAC Transgenic and Knock-Out Mouse Model of Lowe Syndrome Nephropathy
    Robert L Nussbaum; Fiscal Year: 2013
    ..We will also use recombination in mouse embryonic stem cells to dissect and identify the differences between INPP5B and Inpp5b responsible for the difference in phenotype ..
  34. Novel Regenerative Therapy for Myocardial Infarction
    Andrew R Mendelsohn; Fiscal Year: 2011
    ..However, adult stem cell therapy with bone-marrow-derived stem cells to date has only resulted in about 3% average gain in LV function over 13 clinical trials (Martin-Rendon et al...
  35. Hematopoietic Stem Cells (HSCs) as Juvenile Protective Factors that Alter Aging
    David E Harrison; Fiscal Year: 2011
    ..applicant): Detrimental effects of aging might be due in part to loss of juvenile protective factors, including stem cells. Murine hematopoiesis is ideal for investigating stem cells, because lineages of marrow and blood precursors can ..
  36. Role of murine induced pluripotent stem cells on the correction of cardiac and sk
    Diego Fraidenraich; Fiscal Year: 2010
    b>Stem cells are regarded with great promise in the next decades for treatment of congenital disease...
  37. Role of Potent Trophic Factors on Glia and Motor Neurons in ALS
    Brian K Kaspar; Fiscal Year: 2013
    ..We have developed an in vitro based model of ALS that utilizes stem cells directed to motor neurons and ALS containing astrocytes, which recapitulates the disease...
  38. Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
    Catherine M Gordon; Fiscal Year: 2013
    ..by the pilot imaging data, in particular whether hormonal abnormalities in girls with AN influence mesenchymal stem cells to differentiate preferentially into adipocytes over osteoblasts...
  39. Heat Shock Effects on Human Mesenchymal Stem Cell Differentiation in Hydrogel
    Sihong Wang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Tissue engineering combined with stem cells, an emerging field of regenerative medicine, holds promise for the restoration of tissues and organs damaged by diseases, aging, and trauma...
  40. Mechanism of Irradiation Pulmonary Fibrosis
    Joel S Greenberger; Fiscal Year: 2012
    ..and proliferation of bone marrow origin myofibroblast progenitor cells (bone marrow stromal cells/mesenchymal stem cells), which contribute to pulmonary fibrosis...
  41. Fate of Lung Stem Cells During Pulmonary Disease
    Susan M Majka; Fiscal Year: 2012
    ..ability of primitive progenitor cells to efflux a Hoechst dye via an ABCG2 transporter which is common to adult stem cells, termed the side population (SP)...
  42. MECHANISMS OF FGF RECEPTOR REGULATION AND SIGNALING
    Moosa Mohammadi; Fiscal Year: 2013
    ..of drugs for tissue repair and bioengineering, promotion of self- renewal and differentiation of human embryonic stem cells for cell-replacement therapy...
  43. Hematopoietic Stem Cell Transplantation in Osteogenesis Imperfecta
    Meenal Mehrotra; Fiscal Year: 2012
    ..Thus, I have decided to combine my background in bone biology with my current studies of stem cells to investigate the hematopoietic stem cells (HSCs) as a potential therapy for bone disorders...
  44. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
    ..of CSS will improve, and elective surgery and adnexal structures will be enabled by selection for the somatic stem cells (SSC) of the epidermis, and preservation of the SSC phenotype during keratinocyte culture;and, b) keratinocytes ..
  45. B Cell Development in Aging
    John C Cambier; Fiscal Year: 2010
    ..reduced in numbers, and this is correlated with reduction in the FO B cell generative capacity of hematopoietic stem cells (HSCs)...
  46. The Role of Interferon-gamma in the Regulation of Hematopoietic Stem Cells
    KATHERINE YUDEH KING; Fiscal Year: 2013
    ..Cells of the host immune response are ultimately derived from hematopoietic stem cells (HSCs) in bone marrow...
  47. SATB1-dependent epigenetic regulation of leukemia initiating cells
    Britta Will; Fiscal Year: 2011
    ..In the hematopoietic system, the interplay of particular transcription factors instructs normal hematopoietic stem cells (HSC) to function in a precise manner...
  48. Testing the Therapeutic Potential of iPS Cells for Inherited Skin Diseases
    Jakub Tolar; Fiscal Year: 2013
    ..Since the epidermis is continuously renewed by stem cells in the proliferative basal layer, a permanent corrective therapy for EB must target the stem cell population...
  49. Dietary Risk for Colon Cancer in the Mouse
    Leonard H Augenlicht; Fiscal Year: 2013
    ..Aim 1, determines how the higher risk diet alters the number and positional distribution of Lgr5+ intestinal stem cells, allocation of these cells to different lineages, the role of Wnt and Notch signaling and their interaction in ..
  50. Use of umbilical cord as a unique stem cell source for tissue regeneration
    Xiao Dong Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human umbilical cord blood (UCB) contains mesenchymal stem cells (MSCs) that have higher multipotentiality than adult marrow-derived MSCs (BM-MSCs)...
  51. Development of a Pediatric Mylelodysplastic Syndrome Patient Registry
    DAVID A contact WILLIAMS; Fiscal Year: 2010
    ..This project will be lead by Drs. David A. Williams (known for his expertise in hematopoietic stem cells and bone marrow failure disorders) and Mark D...
  52. Neonatal Chemoselection Following Ex Vivo Gene Transfer For Hereditary Disorders
    KARIN L GAENSLER; Fiscal Year: 2012
    ..of inherited disorders, is limited by a shortage of compatible donors, low numbers of engrafting hematopoietic stem cells (HSC), the toxicity of necessary preparative regimens and post-transplant immunosuppression, and graft vs...
  53. Erythropoietin in Non-Erythroid Cells: Function and Regulation
    Josef T Prchal; Fiscal Year: 2013
    ..reported and transcripts of EPO and/or its receptor (EPOR) genes are found in brain, endothelium, hematopoietic stem cells, breast, ovary, testes, and other tissues...
  54. Pluripotent human stem cells as models for normal and diseased trophoblast
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2013
    ..by applicant): The main goal of this proposal is to generate extravillous trophoblast (EVT) from human embryonic stem cells (hESC) after they have been treated with BMP4 (BMP-hESC) and use them as a model to study EVT emergence, ..
  55. Muscle stem cell therapy in a mouse model of premature aging
    Johnny Huard; Fiscal Year: 2010
    ..We previously isolated and characterized a population of muscle-derived stem cells (MDSCs) that displays a high regenerative capacity in various tissues of the musculoskeletal system...
  56. THE EFFECT OF DIOXINS ON GLUCOSE HOMEOSTASIS IN MURINE TESTES
    KENAN RIFAT OMURTAG; Fiscal Year: 2013
    ..In addition we seek to determine if dioxin exposure affects gene expression in the germ cells and perhaps stem cells at different stages of spermatogenesis...
  57. MicroRNA Regulation of Macrophage Polarization in Muscle Regeneration
    Paula K Shireman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Stem cells and tissue regeneration have great therapeutic promise for treatment of a wide variety of medical conditions...
  58. Maternal Obesity affects AMP-Kinase in Muscle Cell Differentiation
    Min Du; Fiscal Year: 2013
    ..Myocytes, adipocytes and fibroblasts in fetal SM are derived from mesenchymal stem cells (MSC)...
  59. Regulation of Chronic Colitis by Mesenchymal Stem Cells
    Matthew B Grisham; Fiscal Year: 2013
    ..Recent studies demonstrate that bone marrow-derived mesenchymal stem cells (MSCs) have potent immunoregulatory activity in vitro and in vivo...
  60. Bone Marrow Transplantation for Hematologic Malignancies using Novel Radioimmunot
    John M Pagel; Fiscal Year: 2013
    ..In Aim 2 we will assess the relative merits of HCT employing MHC-haploidentical stem cells utilizing myeloablative pretargeted RIT with an anti-CD45 Ab (30F11)-streptavidin (SA) conjugate followed by ..
  61. Aligned Tendon or Ligament Derived Matrix Nanoscaffolds for Rotator Cuff Repair
    Dianne Little; Fiscal Year: 2013
    ..We have shown that a novel TLDM enhances proliferation and early differentiation of human adipose stem cells (hASCs) towards a tendon phenotype and that TLDM can be used to produce hydrospun nanofiber scaffolds...
  62. Regulation of Rhox5 Transcriptional Elongation
    Marcy E Richardson; Fiscal Year: 2013
    ..Recent studies conducted in human embryonic stem cells and Drosophila melanogaster embryos have identified transcriptional elongation as a widely used alternative ..
  63. Deriving hepatocytes from disease specific iPS to treat metabolic liver disorders
    Namita Roy-Chowdhury; Fiscal Year: 2013
    ..This research proposal is to test the hypothesis that induced pluripotent stem cells (iPSC) derived from the skin of patients with Crigler-Najjar syndrome type 1 (CN1), who have severe lifelong ..
  64. ATM Controls Genomic Stability in Pluripotent Stem Cells
    JASON MARK BECKTA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pluripotent stem cells (PSCs) harbor exceptional potential for developing therapeutic advances for many diseases. However, when cultured in vitro, PSCs commonly acquire genetic abnormalities (e.g...
  65. Studying a novel regulator of GBM tumorigeneis: the role of CK2alpha in maintaini
    Gordon Li; Fiscal Year: 2013
    ..built a busy clinical practice as well as run a large NIH-funded laboratory studying the implantation of stem cells for the treatment of stroke. I will meet with him on a monthly basis...
  66. Over-Expression of microRNA-126 in Macrophages for Treatment of Atherosclerosis
    Suzette Laing; Fiscal Year: 2013
    ..Since macrophages derived from bone marrow hematopoietic stem cells (HSC), are key to the initiation and progression of atherosclerosis, the therapeutic potential of over-..
  67. Pluripotent Stem Cells: Modeling syncytiotrophoblast development and pathogenesis
    Danny J Schust; Fiscal Year: 2013
    ..The first goal of this proposal is to generate STB and its mononucleated precursors from human embryonic stem cells (hESC) that have been treated with BMP4 (BMP-hESC) and inhibitors of activin and FGF2 signaling...
  68. Effect of bisphenol A exposure on mammary stem cell function and transformation
    Luzhe Sun; Fiscal Year: 2013
    ..However, the underlying mechanism for these observations is unclear. The murine mammary stem cells (MaSCs) have the potential to drive mammary gland development during puberty, and growth and remodeling during ..
  69. IL-22 in epithelial regeneration after allogeneic transplant
    Alan Hanash; Fiscal Year: 2013
    ..Our data also indicate that the intestinal stem cells (ISC) necessary for nor- mal epithelial maintenance are targets of GVHD, and that IL-22 may be critical for the ..
  70. REGULATION OF ATROPHY-INDUCED PROGENITOR CELLS IN THE GASTRIC CORPUS
    Jason C Mills; Fiscal Year: 2013
    ..g., LGR5) in the intestines and the gastric antrum, relatively little is known about the stem cells of the gastric (body) corpus epithelium...
  71. The Role of Long Non-coding RNAs in EMT and Cancer Stem Cells
    Jason I Herschkowitz; Fiscal Year: 2013
    ..Using a unique mouse model, he has determined that claudin-low tumors are enriched for functional cancer stem cells (CSCs) compared to tumors of other subtypes arising in this model...
  72. Regenerating Human Oral Mucosa by Bone Marrow-derived Mesenchymal Stem Cells
    RUBIE ANN RAKIAN; Fiscal Year: 2013
    ..The proposed research studies will address the capacity of bone marrow-derived mesenchymal stem cells (MSC) to regenerate the oral mucosa epithelium by mimicking an environment in vitro similar to that seen in the ..
  73. Identification of novel target genes for polycythemia vera (PV)
    Shaoguang Li; Fiscal Year: 2013
    ..myeloid leukemia (CML), these Philadelphia chromosome-negative (Ph-) MPNs are also derived from hematopoietic stem cells (HSCs) and have a risk of developing thrombosis and acute leukemia...
  74. Genetic correction of human beta-thalassemic induced pluripotent stem cells
    EIRINI PAPAPETROU; Fiscal Year: 2013
    ..gene regulation and on the generation and genetic modification of patient-specific induced pluripotent stem cells (iPSCs)...
  75. The role of cMET in satellite cells during muscle regeneration
    MICAH TAUBE WEBSTER; Fiscal Year: 2013
    ..Based on these findings, c-Met likely plays a role in adult muscle stem cells, i.e. satellite cells (SCs), during injury induced skeletal muscle regeneration...
  76. Targeted epigenetic silencing of oncogenic Transcription Factors (PQ18)
    Pilar Blancafort; Fiscal Year: 2013
    ..of Sox2, which is highly expressed in breast cancer cell lines, with levels comparable or superior to embryonic stem cells. To direct specific DNAme, we will fuse engineered DNA-binding proteins made of sequence-specific Zinc Finger (..
  77. Repair of Bone Defects with Human Autologous Pluripotent Very Small Embryonic lik
    Russell S Taichman; Fiscal Year: 2013
    ..our phase 1 SBIR showed that a unique population of human, adult, pluripotent, Very Small Embryonic like (VSEL) stem cells, have important bone regenerative properties and could be useful in treating oral-craniofacial disorders...
  78. Mechanisms linking RAS signals to disordered hematopoiesis and myeloid neoplasia
    BENJAMIN BRAUN; Fiscal Year: 2013
    ..MegE lineage commitment in immature populations such as hematopoietic stem cells. This will be addressed using time lapse cell culture methods to observe cell fate in real time, and novel ..
  79. Oocyte-derived R-spondin2 as a Follicle Stimulating Hormone
    AARON JW HSUEH; Fiscal Year: 2013
    ..in the human genome and these secreted proteins have been found to be potent growth factors for adult stem cells in gastrointestinal organs and hair follicles by serving as co-ligands for the Wnt signaling pathway essential ..
  80. The Role of TAF4b in Spermatogonial Stem Cell Maintenance and Self-Renewal
    Eric Gustafson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Understanding how stem cells balance self-renewal with differentiation is paramount in harnessing their therapeutic potential in medicine...
  81. The p110 alpha and delta isoforms of PI3 kinase in hematopoiesis and leukemia
    Kira Gritsman; Fiscal Year: 2013
    ..This is largely attributed to the toxic effects that most antileukemic drugs have on hematopoietic stem cells (HSC), frequently leading to cytopenias...
  82. Interactions between P. aeruginosa and autophagy in Airway epithelial cells
    INDHIRA H DE LA ROSA; Fiscal Year: 2013
    ..Understanding whether P. aeruginosa T3SS negatively affect autophagy could provide insight into P. aeruginosa pathogenesis and new therapeutic targets to promote the clearance of these bacteria. ..
  83. The Molecular Genetics of Early Neurogenesis
    Ethan Bier; Fiscal Year: 2013
    ..For example, to treat dorsal spinal chord injuries one may wish to direct differentiating stem cells to assume sensory or neural crest fates under the control of local inductive signals such as Bone morphogenetic ..
  84. The role of intracellular trafficking pathways in calcium signaling
    Suzette Farber-Katz; Fiscal Year: 2013
    ..factors, which play key roles in immune cells, bone, heart and skeletal muscle, neurons, glia, pancreas and stem cells, are activated in response to Ca2+ mobilization...
  85. Novel mechanisms of immune activation following allogeneic, hematopoietic stem ce
    JOHN JAMES LETTERIO; Fiscal Year: 2013
    ..a role for Cdk5 in lymphocyte activation by 1) developing a new chimeric mouse model in which hematopoietic stem cells from Cdk5 deficient (Cdk5-/-) embryos are used to reconstitute lethally irradiated adult mouse recipients (CDK5-/..
  86. Employing Familial AD Induced Pluripotent Stem Cells to Study Neurodegeneration
    Suman Jayadev; Fiscal Year: 2013
    ..The use of patient derived induced pluripotent stem cells (iPSCs) is an expedient approach to examine the molecular phenotype of specific mutations as well as their cell ..
  87. ROLES AND REGULATION OF P53
    Carol Prives; Fiscal Year: 2013
    ..Cordon-Cardo will also pursue identification of bladder stem cells and the mechanisms by which they are chemoresistant...
  88. The Role of HIF-1 in Neurogenic and Behavior Responses to Antidepressants.
    W TIMOTHY O'BRIEN; Fiscal Year: 2013
    ..In a recent collaboration we found that Hif-1a regulates Wnt/[unreadable]-catenin transcription in embryonic stem cells and neural stem/progenitor cells but not in differentiated neurons...
  89. RV/PA Recoupling by Bone Marrow Derived Mesenchymal Stem Cells
    Luis A Ortiz; Fiscal Year: 2013
    ....
  90. Synthesis of bone-selective osteogenic oxysterols
    Frank Stappenbeck; Fiscal Year: 2013
    ..Multipotent mesenchymal stem cells (MSCs) are precursors of a variety of cell types, including osteoblasts and adipocytes...
  91. Analysis of mDia formins in hematopoietic stem cell engraftment and migration
    Peng Ji; Fiscal Year: 2013
    ..However, their effects on the migration of hematopoietic cells, especially hematopoietic stem cells (HSCs), are poorly understood...
  92. The XXII nd North American Testis Workshop
    WILLIAM WALLACE WRIGHT; Fiscal Year: 2013
    ..2 is: Genome Integrity;Session 3 is: Regulation of Gene Expression;Session 4 is: Somatic Cells;and Session 5 is: Stem Cells and Their Niche...
  93. Protein Kinase C Signaling Mechanisms in Cancer
    Alan P Fields; Fiscal Year: 2013
    ..in vivo;and 5) both PKC? and Mmp10 are required for Kras-mediated transformation of bronchio-alveolar stem cells (BASCs), putative lung tumorinitiating cells (TICs) in vivo...
  94. Measuring signaling pathway dynamics during tissue growth in hydrogels
    Lonnie D Shea; Fiscal Year: 2013
    ..TFs are key regulators of cell phenotype, as evidenced by their ability to generate pluripotent stem cells from fibroblasts, and they are the downstream targets of signaling pathways, which are the target of many ..
  95. East African Cichlids: A Natural Model for Dental Regeneration
    RYAN FREDRIC BLOOMQUIST; Fiscal Year: 2013
    ..I will then employ pulse-chase analysis to verify the location and character of putative stem cells in support of my ISH experiments...
  96. Characterization of Chd7 in central nervous system neural stem cells
    JOSEPH ANTHONY MICUCCI; Fiscal Year: 2013
    ..provided by applicant): Tightly regulated gene expression is essential for the proper function of neural stem cells in developing and adult tissues...
  97. Cellular Retinoic Acid Binding Proteins: Functional Studies
    Lorraine J Gudas; Fiscal Year: 2013
    ..retinoids (vitamin A (retinol) and its derivatives and metabolites), control gene expression in both normal stem cells and in tumors...
  98. Technology platform for development of multi-component preservation solution
    Allison Hubel; Fiscal Year: 2013
    ..Of all of the cells therapies currently in development, mesenchymal stem cells (MSCs) appear to have the greatest diversity of applications and potential for widespread use...
  99. Role of Angiogenic CXC Chemokines in Intramembranous Bone Repair
    Dean T Yamaguchi; Fiscal Year: 2013
    ..bone blood supply initiate a cascade of events to repair disrupted bone given the circumstances that mesenchymal stem cells (MSCs) can differentiate into osteoblasts (OBs) and that new blood supply can be re-established...
  100. Autologous TGF-B-Modified HSC for Repair of Vasodegenerative Diabetic Retinopathy
    STEPHEN BARTELMEZ; Fiscal Year: 2009
    ..We describe here a new approach to target early intermediate stages of vasodegeneration using a stem cells therapy to enhance vessel repair, reverse ischemia and prevent progression to late, sight -threatening stages of ..
  101. Pluripotent Adult Spermatogonial Stem Cells: Prospective for Retinal Degeneration
    Nady Golestaneh; Fiscal Year: 2010
    ..can be derived from mouse embryonic stem (ES) cells and may provide an alternative to adult derived retinal stem cells. In other regions of the central nervous system, the transplantation of neurons derived from ES cells has led to ..