phagocytes

Summary

Top Publications

  1. ncbi Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Trends Immunol 23:549-55. 2002
  2. pmc Resolvin D1 binds human phagocytes with evidence for proresolving receptors
    Sriram Krishnamoorthy
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:1660-5. 2010
  3. pmc Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators
    Jesmond Dalli
    Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Blood 120:e60-72. 2012
  4. ncbi Antimicrobial mechanisms of phagocytes and bacterial evasion strategies
    Ronald S Flannagan
    Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Nat Rev Microbiol 7:355-66. 2009
  5. ncbi S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules
    Dirk Foell
    Department of Pediatrics, Institute of Experimental Dermatology, University of Muenster Albert Schweitzer Str 33, Muenster D 48149, Germany
    J Leukoc Biol 81:28-37. 2007
  6. ncbi Interaction of phagocytes with filamentous fungi
    Axel A Brakhage
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute HKI, Beutenbergstrasse 11a, 07745 Jena, Germany
    Curr Opin Microbiol 13:409-15. 2010
  7. pmc Innate antifungal immunity: the key role of phagocytes
    Gordon D Brown
    Aberdeen Fungal Group, Section of Immunology and Infection, Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, United Kingdom
    Annu Rev Immunol 29:1-21. 2011
  8. ncbi Salmonella gut invasion involves TTSS-2-dependent epithelial traversal, basolateral exit, and uptake by epithelium-sampling lamina propria phagocytes
    Andreas J Müller
    Institute of Microbiology, D BIOL, ETH Zurich, 8093 Zurich, Switzerland
    Cell Host Microbe 11:19-32. 2012
  9. pmc A specific primed immune response in Drosophila is dependent on phagocytes
    Linh N Pham
    Department of Microbiology and Immunology, Stanford University, Stanford, California, United States of America
    PLoS Pathog 3:e26. 2007
  10. ncbi Phagocytosis: elegant complexity
    Lynda M Stuart
    Laboratory of Developmental Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Immunity 22:539-50. 2005

Research Grants

  1. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
  2. Trichothecene Toxicity and the Ribotoxic Stress Response
    James J Pestka; Fiscal Year: 2012
  3. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2011
  4. Novel Peptide MPO Inhibitors for Treating Atherosclerosis
    Kirkwood A Pritchard; Fiscal Year: 2012
  5. Global regulatory interactions in bacterial pathogenesis
    BRIAN AKERLEY; Fiscal Year: 2009
  6. Maternal Autoantibodies: Pathogenesis of Neonatal Lupus
    JILL PAMELA BUYON; Fiscal Year: 2013
  7. Nanomedicine and NeuroAIDS
    Howard E Gendelman; Fiscal Year: 2013
  8. Group B. Streptococci and Toll-like Receptors
    Douglas T Golenbock; Fiscal Year: 2012
  9. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2013
  10. COCHLEAR MACROPHAGES AND EPITHELIAL REPAIR
    Keiko Hirose; Fiscal Year: 2013

Detail Information

Publications338 found, 100 shown here

  1. ncbi Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Trends Immunol 23:549-55. 2002
    Mononuclear phagocytes are versatile cells that can express different functional programs in response to microenvironmental signals...
  2. pmc Resolvin D1 binds human phagocytes with evidence for proresolving receptors
    Sriram Krishnamoorthy
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:1660-5. 2010
    ..These results indicate that RvD1 specifically interacts with both ALX and GPR32 on phagocytes and suggest that each plays a role in resolving acute inflammation.
  3. pmc Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators
    Jesmond Dalli
    Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Blood 120:e60-72. 2012
    b>Phagocytes orchestrate acute inflammation and host defense. Here we carried out lipid mediator (LM) metabololipidomics profiling distinct phagocytes: neutrophils (PMN), apoptotic PMN, and macrophages...
  4. ncbi Antimicrobial mechanisms of phagocytes and bacterial evasion strategies
    Ronald S Flannagan
    Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Nat Rev Microbiol 7:355-66. 2009
    Professional phagocytes have a vast and sophisticated arsenal of microbicidal features...
  5. ncbi S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules
    Dirk Foell
    Department of Pediatrics, Institute of Experimental Dermatology, University of Muenster Albert Schweitzer Str 33, Muenster D 48149, Germany
    J Leukoc Biol 81:28-37. 2007
    ....
  6. ncbi Interaction of phagocytes with filamentous fungi
    Axel A Brakhage
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute HKI, Beutenbergstrasse 11a, 07745 Jena, Germany
    Curr Opin Microbiol 13:409-15. 2010
    ..In addition, A. fumigatus interferes with the innate immunity, with both the complement system and defense mechanisms of phagocytes, thereby evading at least in part the innate immune system.
  7. pmc Innate antifungal immunity: the key role of phagocytes
    Gordon D Brown
    Aberdeen Fungal Group, Section of Immunology and Infection, Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, United Kingdom
    Annu Rev Immunol 29:1-21. 2011
    ..This review covers the functions of phagocytes in innate antifungal immunity, along with selected examples of the strategies that are used by fungal pathogens ..
  8. ncbi Salmonella gut invasion involves TTSS-2-dependent epithelial traversal, basolateral exit, and uptake by epithelium-sampling lamina propria phagocytes
    Andreas J Müller
    Institute of Microbiology, D BIOL, ETH Zurich, 8093 Zurich, Switzerland
    Cell Host Microbe 11:19-32. 2012
    ..being released into the lamina propria, the bacterium is transiently extracellular before being taken up by phagocytes, including CD11c(+)CX(3)CR1(high) monocytic phagocytes (MPs), which were found to constitutively sample cellular ..
  9. pmc A specific primed immune response in Drosophila is dependent on phagocytes
    Linh N Pham
    Department of Microbiology and Immunology, Stanford University, Stanford, California, United States of America
    PLoS Pathog 3:e26. 2007
    ..pneumoniae-induced protection. The mechanism underlying this protective effect requires phagocytes and the Toll pathway. However, activation of the Toll pathway is not sufficient for priming-induced protection...
  10. ncbi Phagocytosis: elegant complexity
    Lynda M Stuart
    Laboratory of Developmental Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Immunity 22:539-50. 2005
    ..We also indicate an important role for genetically tractable model organisms in defining key components of this evolutionarily conserved process...
  11. pmc Differential phagocytosis of white versus opaque Candida albicans by Drosophila and mouse phagocytes
    Matthew B Lohse
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California, USA
    PLoS ONE 3:e1473. 2008
    ..albicans, and propose that one role of switching from the prevalent white form into the rarer opaque form may be to allow C. albicans to escape phagocytosis...
  12. ncbi Flow cytometric quantitative determination of ingestion by phagocytes needs the distinguishing of overlapping populations of binding and ingesting cells
    Jari Nuutila
    Department of Biochemistry, University of Turku, Turku, Finland
    Cytometry A 65:93-102. 2005
    ..This report describes an improved flow cytometric method of analysis for kinetic measurement of phagocytosis of fluorescein isothiocyanate (FITC)-labeled zymosan particles by human leukocytes...
  13. ncbi The phagocytes: neutrophils and monocytes
    David C Dale
    Department of Medicine, University of Washington School of Medicine, Seattle A98195, USA
    Blood 112:935-45. 2008
    The production and deployment of phagocytes are central functions of the hematopoietic system...
  14. ncbi Phagocytosis of microbes: complexity in action
    David M Underhill
    Institute for Systems Biology, 1441 North 34 Street, Seattle, Washington 98103, USA
    Annu Rev Immunol 20:825-52. 2002
    ..Indeed, pathogenic microorganisms target many of these molecules in their attempts to evade destruction...
  15. pmc Staphylococcus aureus Panton-Valentine leukocidin induces an inflammatory response in human phagocytes via the NLRP3 inflammasome
    Dirk Holzinger
    Institute of Immunology, Department of General Pediatrics, University Children s Hospital Munster, Munster, Germany
    J Leukoc Biol 92:1069-81. 2012
    ..This study analyzes a specific host signaling pathway that mediates PVL-induced inflammation and cytotoxicity, which has high relevance for CA-MRSA-associated and PVL-mediated pathogenic processes, such as necrotizing infections...
  16. pmc Mycobacterium leprae phenolglycolipid-1 expressed by engineered M. bovis BCG modulates early interaction with human phagocytes
    Guillaume Tabouret
    CNRS, IPBS Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
    PLoS Pathog 6:e1001159. 2010
    ..PGL-1 production also promoted bacterial uptake by human dendritic cells and dampened their infection-induced maturation. Our results therefore suggest that M. leprae produces PGL-1 for immune-silent invasion of host phagocytic cells...
  17. pmc Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease
    Felix Meissner
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany
    Blood 116:1570-3. 2010
    ..CGD is caused by mutations in subunits of the NADPH oxidase, an enzyme that generates reactive oxygen species in phagocytes. To elucidate the contribution of the proinflammatory protease caspase-1 to aberrant inflammatory reactions in ..
  18. pmc HIF-1alpha expression regulates the bactericidal capacity of phagocytes
    Carole Peyssonnaux
    Division of Biological Sciences, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA
    J Clin Invest 115:1806-15. 2005
    ..HIF-1alpha control of myeloid cell activity in infected tissues could represent a novel therapeutic target for enhancing host defense...
  19. ncbi Assembly of the phagocyte NADPH oxidase
    William M Nauseef
    Inflammation Program and Department of Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, D160 MTF, 2501 Crosspark Road, Coralville, IA 52241, USA
    Histochem Cell Biol 122:277-91. 2004
    Stimulated phagocytes undergo a burst in respiration whereby molecular oxygen is converted to superoxide anion through the action of an NADPH-dependent oxidase...
  20. ncbi The role of phosphatidylserine in recognition of apoptotic cells by phagocytes
    V A Fadok
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206 USA
    Cell Death Differ 5:551-62. 1998
    ..has several potential biological consequences, one of which is recognition and removal of the apoptotic cell by phagocytes. It is still not clear which receptors mediate PS recognition on apoptotic cells; however, several interesting ..
  21. ncbi Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria
    Chen Varol
    Gastroenterology and Hepatology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Nat Rev Immunol 10:415-26. 2010
    ..Mononuclear phagocytes promote both innate and adaptive immune responses in the gut and, as such, are essential for the maintenance of ..
  22. pmc The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems
    Andrew R Cross
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1657:1-22. 2004
    ..A number of homologous systems have been discovered in plants and lower animals as well as in man. Their function remains to be established...
  23. ncbi Exploration of host-pathogen interactions using Listeria monocytogenes and Drosophila melanogaster
    Bryce E Mansfield
    Department of Pathobiology, University of Washington, USA
    Cell Microbiol 5:901-11. 2003
    ..monocytogenes infection...
  24. ncbi Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitidis serogroup B
    D L Jack
    Immunobiology Unit, Institute of Child Health, University College, London, United Kingdom
    J Infect Dis 184:1152-62. 2001
    The influence of the innate immune protein mannose-binding lectin (MBL) on the response of human phagocytes to Neisseria meningitidis was investigated...
  25. ncbi Adiponectin and its globular fragment differentially modulate the oxidative burst of primary human phagocytes
    Pia Chedid
    INSERM U773, Paris, France
    Am J Pathol 180:682-92. 2012
    ..Acrp30 inhibited fMLF-induced ROS production by human phagocytes, whereas gAcrp30 enhanced it...
  26. pmc MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice
    Namiko Hoshi
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Commun 3:1120. 2012
    ..Specifically, phenotypically distinct populations of colonic mononuclear phagocytes expressed high levels of interleukin-1β, interleukin-23 and interleukin-6, and promoted T-helper 17 responses ..
  27. pmc The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3
    C D Dijkstra
    Immunology 54:589-99. 1985
    ..No other cell types except cells of the mononuclear phagocyte system are positive for any of the three monoclonals. Possible relations between the macrophages recognized by this set of monoclonals and dendritic cells are discussed...
  28. pmc MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP
    Lei Jin
    Integrated Department of Immunology, University of Colorado Denver School of Medicine, Denver, CO 80206, USA
    J Immunol 187:2595-601. 2011
    ..Our findings indicate that bifurcating MPYS-dependent and -independent pathways mediate sensing of cytosolic bacterial infections...
  29. ncbi Measurement of respiratory burst products generated by professional phagocytes
    Claes Dahlgren
    Department of Rheumatology and Inflammation Research, University of Goteborg, Goteborg, Sweden
    Methods Mol Biol 412:349-63. 2007
    Activation of professional phagocytes, potent microbial killers of our innate immune system, is associated with an increase in cellular consumption of molecular oxygen (O2)...
  30. ncbi Dynamics of bacterial growth and distribution within the liver during Salmonella infection
    Mark Sheppard
    Bacterial Infection Group, Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Cell Microbiol 5:593-600. 2003
    ..Using fast-growing and slow-growing bacteria we also showed that the increase in the number of infected phagocytes parallels the net rate of bacterial growth of the microorganisms in the tissues...
  31. pmc The presence of professional phagocytes dictates the number of host cells targeted for Yop translocation during infection
    Enrique A Durand
    Department of Molecular Biology and Microbiology, Tufts University, Boston MA 02111, USA
    Cell Microbiol 12:1064-82. 2010
    ..pseudotuberculosis selectively targets Yops to professional phagocytes in Peyer's patches, mesenteric lymph nodes and spleen, although it colocalizes with B and T cells as well as ..
  32. pmc Transplanted neural stem/precursor cells instruct phagocytes and reduce secondary tissue damage in the injured spinal cord
    Melania Cusimano
    Dept of Clinical Neurosciences, Cambridge Centre for Brain Repair and Cambridge Stem Cell Initiative, University of Cambridge, E D Adrian Building, Forvie Site, Robinson Way, Cambridge CB2 0PY, UK
    Brain 135:447-60. 2012
    ..survived undifferentiated at the level of the peri-lesion environment and established contacts with endogenous phagocytes via cellular-junctional coupling...
  33. ncbi Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota
    Stephanie C Ganal
    IMMH, Institute of Medical Microbiology and Hygiene, University of Freiburg, Hermann Herder Strasse 11, Freiburg, Germany
    Immunity 37:171-86. 2012
    Mononuclear phagocytes are an important component of an innate immune system perceived as a system ready to react upon encounter of pathogens...
  34. ncbi In vivo depletion of CD4+FOXP3+ Treg cells by the PC61 anti-CD25 monoclonal antibody is mediated by FcgammaRIII+ phagocytes
    Yulius Y Setiady
    ImmunoGen, Inc, Waltham, MA 02451, USA
    Eur J Immunol 40:780-6. 2010
    ..Depletion of NK cells had no effect, whereas depletion of phagocytes, including macrophages, by clodronate liposome significantly inhibited Treg depletion...
  35. ncbi Immunology of cutaneous leishmaniasis: the role of mast cells, phagocytes and dendritic cells for protective immunity
    Esther von Stebut
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz
    Eur J Dermatol 17:115-22. 2007
    Millions of Leishmania major infections in humans are reported worldwide. In experimental infections, various phagocytes predominant in skin--neutrophils, macrophages (MPhi) and dendritic cells (DC)--play very distinct roles for the hosts'..
  36. ncbi Pharmacologic augmentation of hypoxia-inducible factor-1alpha with mimosine boosts the bactericidal capacity of phagocytes
    Annelies S Zinkernagel
    1Division of Pediatric Pharmacology and Drug Discovery, School of Medicine, University of California, San Diego, La Jolla 92093 0687, USA
    J Infect Dis 197:214-7. 2008
    ..factor (HIF)-1alpha is activated on exposure to bacterial pathogens and regulates the innate immune functions of phagocytes. We show here that the HIF-1alpha agonist mimosine can boost the capacity of human phagocytes and whole blood to ..
  37. pmc The p47phox mouse knock-out model of chronic granulomatous disease
    S H Jackson
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1886, USA
    J Exp Med 182:751-8. 1995
    ..This model mirrors human CGD and confirms a critical role for the phagocyte NADPH oxidase in mammalian host defense...
  38. pmc Phagocytes containing a disease-promoting Toll-like receptor/Nod ligand are present in the brain during demyelinating disease in primates
    Lizette Visser
    Department of Immunology, Erasmus Medical Center, University Medical Center Rotterdam, PO Box 2040, 3000 DR Rotterdam, The Netherlands
    Am J Pathol 169:1671-85. 2006
    ..The number of phagocytes carrying PGN increased in acute and chronic EAE compared with control animals, with the highest number of PGN-..
  39. ncbi Genetic ablation of Drosophila phagocytes reveals their contribution to both development and resistance to bacterial infection
    Arnaud Defaye
    Centre de Genetique Moleculaire, CNRS FRE 3144, Gif sur Yvette, France
    J Innate Immun 1:322-34. 2009
    Drosophila phagocytes participate in development and immune responses through their abilities to perform phagocytosis and/or secrete extra-cellular matrix components, antimicrobial peptides, clotting factors and signalling molecules...
  40. pmc Interactions between human phagocytes and Candida albicans biofilms alone and in combination with antifungal agents
    Aspasia Katragkou
    Laboratory of Infectious Diseases, Third Department of Pediatrics, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece
    J Infect Dis 201:1941-9. 2010
    Biofilm formation is an important component of vascular catheter infections caused by Candida albicans. Little is known about the interactions between human phagocytes, antifungal agents, and Candida biofilms.
  41. pmc Pseudomonas aeruginosa Type III secretion system interacts with phagocytes to modulate systemic infection of zebrafish embryos
    Mark K Brannon
    Department of Pediatrics, University of Washington, Seattle, WA, USA
    Cell Microbiol 11:755-68. 2009
    ..is an opportunistic human pathogen that can cause serious infection in those with deficient or impaired phagocytes. We have developed the optically transparent and genetically tractable zebrafish embryo as a model for systemic ..
  42. ncbi Suppression of experimental colitis by intestinal mononuclear phagocytes
    Joseph E Qualls
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, College of Medicine, Lexington, KY 40536 0084, USA
    J Leukoc Biol 80:802-15. 2006
    ..The goal of this study was to determine if intestinal mononuclear phagocytes (iMNP) serve a pathological or protective role in dextran sulfate sodium (DSS)-induced colitis in mice...
  43. ncbi Interaction of pathogenic yeasts with phagocytes: survival, persistence and escape
    Katja Seider
    Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute Jena HKI, Jena, Germany
    Curr Opin Microbiol 13:392-400. 2010
    ..In order to evade or counteract attack by phagocytes, pathogenic yeasts have acquired a repertoire of strategies to survive, colonize and infect the host...
  44. pmc Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes
    Yoshito Takeda
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Japan
    J Cell Biol 161:945-56. 2003
    ..Here, we investigated the role of these tetraspanins in the fusion of mononuclear phagocytes. Expression of CD9 and CD81 and their complex formation with integrins were up-regulated when blood monocytes ..
  45. ncbi Mouse B-1 cell-derived mononuclear phagocyte, a novel cellular component of acute non-specific inflammatory exudate
    S R Almeida
    Discipline of Immunology, Department of Microbiology, Immunology and Parasitology, and Center of Electron Microscopy, , Rua Botucatu 862, 04023-9000, , Brazil
    Int Immunol 13:1193-201. 2001
    ..These data demonstrate that B-1 cells, mainly B-1b cells, not only proliferate and differentiate into a mononuclear phagocyte in vitro, but also that they exit the peritoneal cavity and migrate to a non-specific inflammatory milieu...
  46. ncbi MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes
    Thomas Vogl
    Institute of Experimental Dermatology, Department of Pediatrics, University of Munster, Röntgenstrasse 21, D 48149 Munster, Germany
    Blood 104:4260-8. 2004
    ..Targeted gene disruption reveals an essential role of this S100 protein for transendothelial migration of phagocytes. The underlying molecular mechanism comprises major alterations of cytoskeletal metabolism...
  47. ncbi Multiple receptors mediate apoJ-dependent clearance of cellular debris into nonprofessional phagocytes
    M M Bartl
    , Johannes Gutenberg-University, Mainz, D-55099, Federal Republic of Germany
    Exp Cell Res 271:130-41. 2001
    ..mediate uptake into macrophages, it is poorly understood how cellular debris is internalized by nonprofessional phagocytes. We here analyze the endocytic activity of vital fibroblasts and epithelial cells exposed to cellular debris and ..
  48. pmc Differential infection of mononuclear phagocytes by Francisella tularensis: role of the macrophage mannose receptor
    Grant S Schulert
    Inflammation Program and Department of Microbiology, University of Iowa, 2501 Crosspark Rd, Coralville, 52241, USA
    J Leukoc Biol 80:563-71. 2006
    ..Conversely, MDM used MR and CD11b/CD18 to ingest opsonized organisms. Altogether, our data demonstrate differential infection of mononuclear phagocytes by Ft and define distinct roles for MR and CR3 in phagocytosis.
  49. pmc Interaction of neonatal phagocytes with group B streptococcus: recognition and response
    Philipp Henneke
    Zentrum für Kinderheilkunde und Jugendmedizin, Albert Ludwigs Universitat Freiburg, Mathildenstr 1, 79106 Freiburg, Germany
    Infect Immun 74:3085-95. 2006
  50. ncbi Corpse clearance defines the meaning of cell death
    J Savill
    University of Edinburgh Medical Research Council Centre for Inflammation Research, Department of Clinical and Surgical Sciences, Internal Medicine, Royal Infirmary, UK
    Nature 407:784-8. 2000
    ..Apoptosis marks unwanted cells with 'eat me' signals that direct recognition, engulfment and degradation by phagocytes. Far from being the end of the story, these clearance events allow scavenger cells to confer meaning upon cell ..
  51. ncbi Role of Nox2 in elimination of microorganisms
    Balázs Rada
    Laboratory of Host Defenses, Molecular Defenses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA
    Semin Immunopathol 30:237-53. 2008
    ..The goals of this contribution are to provide critical review of the Nox2-dependent cellular processes that potentially contribute to bacterial killing and degradation and to indicate possible targets of pharmacological interventions...
  52. ncbi Identification of a factor that links apoptotic cells to phagocytes
    Rikinari Hanayama
    Department of Genetics, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Nature 417:182-7. 2002
    Apoptotic cells are rapidly engulfed by phagocytes to prevent the release of potentially noxious or immunogenic intracellular materials from the dying cells, thereby preserving the integrity and function of the surrounding tissue...
  53. pmc Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer's-like disease progression
    Dan Frenkel
    Department of Neurobiology, Sagol School of Neuroscience, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 699788, Israel
    Nat Commun 4:2030. 2013
    ..In contrast, pharmacological upregulation of Scara1 expression on mononuclear phagocytes increases Aβ clearance. This approach is a potential treatment strategy for Alzheimer's disease.
  54. pmc The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosi
    T Miyata
    Department of Internal Medicine, Branch Hospital, Nagoya University School of Medicine, Japan
    J Clin Invest 98:1088-94. 1996
    ..We demonstrate here that the interaction of AGE-beta2M with mononuclear phagocytes (MPs), cells important in the pathogenesis of the inflammatory arthropathy of dialysis-related amyloidosis, is ..
  55. pmc Unravelling mononuclear phagocyte heterogeneity
    Frederic Geissmann
    King s College London, Guy s Campus, London SE1 1UL, UK
    Nat Rev Immunol 10:453-60. 2010
    ..Here, Nature Reviews Immunology asks five experts to discuss the issue of heterogeneity in the mononuclear phagocyte system and to give their opinion on the importance of defining these cells for future research...
  56. ncbi C. elegans secreted lipid-binding protein NRF-5 mediates PS appearance on phagocytes for cell corpse engulfment
    Yan Zhang
    Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
    Curr Biol 22:1276-84. 2012
    During programmed cell death, apoptotic cells are rapidly removed by phagocytes. How dying cells are recognized remains poorly understood.
  57. pmc Characterization of Staphylococcus aureus cardiolipin synthases 1 and 2 and their contribution to accumulation of cardiolipin in stationary phase and within phagocytes
    T Koprivnjak
    Department of Biotechnology, National Institute of Chemistry Slovenia, Hajdrihova 19, 1000 Ljubljana, Slovenia
    J Bacteriol 193:4134-42. 2011
    ..Differences in the relative contributions of Cls1 and Cls2 to CL accumulation under different triggering conditions suggest differences in the role and regulation of these two enzymes...
  58. pmc Fibrin(ogen) mediates acute inflammatory responses to biomaterials
    L Tang
    Division of Experimental Pathology, Albany Medical College, New York 12208
    J Exp Med 178:2147-56. 1993
    ..very few adherent neutrophils or macrophages, whereas uncoated or plasma-coated PET attracts large numbers of phagocytes. Neither IgG adsorption nor surface complement activation is necessary for this acute inflammation; phagocyte ..
  59. ncbi Interactions between professional phagocytes and Brucella spp
    J P Liautard
    INSERM U 431, Universite Montpellier II, France
    Microbiologia 12:197-206. 1996
    ..This review is devoted to the relations between Brucella spp. and professional phagocytes, particularly macrophages and macrophagic cell lines in vitro...
  60. pmc Characterization of mononuclear phagocytic cells in medaka fish transgenic for a cxcr3a:gfp reporter
    Narges Aghaallaei
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Proc Natl Acad Sci U S A 107:18079-84. 2010
    ..Our results identify a marker of teleost mononuclear phagocytic cells and suggest a surprising degree of morphological and functional similarity between the innate immune systems of lower and higher vertebrates...
  61. pmc Co-ordinated expression of lymphoid and myeloid specific transcription factors during B-1b cell differentiation into mononuclear phagocytes in vitro
    Ana F Popi
    Universidade Federal de Sao Paulo, Department of Microbiology, Immunology and Parasitology, Sao Paulo, Brazil
    Immunology 126:114-22. 2009
    ..Furthermore, B-1b cell-derived phagocytes (B-1CDPs) decrease immunoglobulin M (IgM) expression but retain the expression of the heavy chain variable gene ..
  62. pmc Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: new role for the NADPH oxidase in host defense
    Jacob M Rothfork
    Research Service, Albuquerque Veterans Affairs Medical Center, Albuquerque, NM 87108, USA
    Proc Natl Acad Sci U S A 101:13867-72. 2004
    ..Thus, oxidant-mediated inactivation of an autoinducing peptide from S. aureus is a critical innate defense mechanism against infection with this pathogen...
  63. ncbi Activation and deactivation of periventricular white matter phagocytes during postnatal mouse development
    Mariya Hristova
    Department of Obstetrics and Gynecology, EGA Institute of Women s Health, University College London, London, United Kingdom
    Glia 58:11-28. 2010
    ..P7 white matter phagocytes also expressed high levels of IGF1 and MCSF, but not TNFalpha mRNA; this expression disappeared at P14...
  64. pmc Kidney dendritic cells induce innate immunity against bacterial pyelonephritis
    André P Tittel
    Institutes of Molecular Medicine and Experimental Immunology IMMEI, Rheinische Friedrich Wilhelms Universita t, Bonn, Germany
    J Am Soc Nephrol 22:1435-41. 2011
    ..In conclusion, these findings suggest that the tubulointerstitial dendritic cell network serves an innate immune sentinel function against bacterial pyelonephritis...
  65. ncbi Injury switches melatonin production source from endocrine (pineal) to paracrine (phagocytes) - melatonin in human colostrum and colostrum phagocytes
    Gerlândia N Pontes
    Laboratory of Chronopharmacology, Department of Physiology, Institute of Bioscience, Universidade de Sao Paulo, Sao Paulo, Brazil
    J Pineal Res 41:136-41. 2006
    ..melatonin levels in milk reflects pineal activity and (b) colostrum quiescent mononuclear and polymorphonuclear phagocytes from healthy mothers in culture are adequate for evaluating the ability of immunocompetent cells to produce ..
  66. pmc Capnocytophaga canimorsus: a human pathogen feeding at the surface of epithelial cells and phagocytes
    Manuela Mally
    Infection Biology, Biozentrum, University of Basel, Klingelbergstrasse, Basel, Switzerland
    PLoS Pathog 4:e1000164. 2008
    ..canimorsus exhibits robust growth when it is in direct contact with mammalian cells, including phagocytes. This property was found to be dependent on a surface-exposed sialidase allowing C...
  67. pmc Ensheathing glia function as phagocytes in the adult Drosophila brain
    Johnna Doherty
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    J Neurosci 29:4768-81. 2009
    ..argue that ensheathing glia and astrocytes are preprogrammed cell types in the adult Drosophila brain, with ensheathing glia acting as phagocytes after axotomy, and astrocytes potentially modulating synapse formation and signaling.
  68. ncbi Inflammatory manifestations in chronic granulomatous disease (CGD)
    S D Rosenzweig
    Servicio de Inmunologia, Hospital Nacional de Pediatria J P Garrahan, Combate de los Pozos 1881, 1245 Buenos Aires, Argentina
    J Clin Immunol 28:S67-72. 2008
    ..In this review we will focus our attention on those particular inflammatory manifestations associated with CGD, their frequencies and the underlying immunologic mechanisms favoring it occurrence...
  69. pmc CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils
    Indra Sethy Coraci
    Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Pathol 160:101-12. 2002
    ..We propose that similar to their role in the interaction of macrophages with oxLDL, class A scavenger receptors and CD36 play complimentary roles in the interactions of microglia with fibrillar beta-amyloid...
  70. pmc Phagosome maturation: going through the acid test
    Jason M Kinchen
    Beirne B Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22902, USA
    Nat Rev Mol Cell Biol 9:781-95. 2008
    ..This suggests that a machinery that is distinct from receptor-mediated endocytosis is used in phagosome maturation...
  71. pmc Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-{gamma} sumoylation, and HIF-1{alpha}
    Sophie Gibbings
    Division of Pulmonary Sciences, Division of Pulmonary Sciences, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Biol Chem 286:961-75. 2011
    ..We previously observed that inhibition of XOR within the inflammatory mononuclear phagocytes (MNP) prevented neutrophil recruitment during adoptive transfer demonstrating the role of XOR in MNP-mediated ..
  72. pmc Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox
    W A Edens
    Department of Biochemistry, Emory University Medical School, Atlanta, GA 30322, USA
    J Cell Biol 154:879-91. 2001
    ..Thus, Ce-Duox catalyzes the cross-linking of tyrosine residues involved in the stabilization of cuticular extracellular matrix...
  73. pmc Live Candida albicans suppresses production of reactive oxygen species in phagocytes
    Melanie Wellington
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 690, Rochester, NY 14642, USA
    Infect Immun 77:405-13. 2009
    Production of reactive oxygen species (ROS) is an important aspect of phagocyte-mediated host responses. Since phagocytes play a crucial role in the host response to Candida albicans, we examined the ability of Candida to modulate ..
  74. ncbi Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain
    H L Tiffany
    Molecular Signaling and Genetic Immunotherapy Sections, Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20982, USA
    J Biol Chem 276:23645-52. 2001
    ..Amyloid-beta was also a specific agonist at the human counterpart of FPR2, the FPR-like 1 receptor. These results suggest a unified signaling mechanism for linking amyloid-beta to phagocyte chemotaxis and oxidant stress in the brain...
  75. ncbi Dangerous attraction: phagocyte recruitment and danger signals of apoptotic and necrotic cells
    Christoph Peter
    Department of Internal Medicine I, University of Tuebingen, Germany
    Apoptosis 15:1007-28. 2010
    ..in metazoa requires the rapid and efficient clearance of dying cells by professional or semi-professional phagocytes. Impairment of this finely regulated, fundamental process has been implicated in the development of autoimmune ..
  76. ncbi Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte
    Shyra J Gardai
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, Colorado 80206, USA
    Cell 123:321-34. 2005
    ....
  77. ncbi Differences between the clearance of apoptotic cells by professional and non-professional phagocytes
    R Parnaik
    Medical Research Council Laboratory for Molecular Cell Biology, Medical Research Council Developmental Neurobiology Programme, University College London, London, WC1E 6BT, UK
    Curr Biol 10:857-60. 2000
    Both professional and non-professional phagocytes [1] participate in clearing the massive numbers of cells that undergo apoptosis during animal development [2], but it is not known how they divide this task...
  78. pmc Common themes in microbial pathogenicity revisited
    B B Finlay
    Biotechnology Laboratory, University of British Columbia, Vancouver, Canada
    Microbiol Mol Biol Rev 61:136-69. 1997
    ....
  79. ncbi Signalling through TLR2/MyD88 induces differentiation of murine bone marrow stem and progenitor cells to functional phagocytes in response to Candida albicans
    Alberto Yáñez
    Departamento de Microbiologia y Ecologia, Universitat de Valencia, Burjassot, Spain
    Cell Microbiol 12:114-28. 2010
    ..In conclusion, C. albicans may be sensed by TLRs on haematopoietic stem and progenitor cells to promote the host capability for rapidly replenishing myeloid cells that constitute the first line of defence against C. albicans...
  80. ncbi The final step in programmed cell death: phagocytes carry apoptotic cells to the grave
    Aimee M DeCathelineau
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, U S A
    Essays Biochem 39:105-17. 2003
    As cells undergo apoptosis, they are recognized and removed from the body by phagocytes. This oft-overlooked yet critical final step in the cell-death programme protects tissues from exposure to the toxic contents of dying cells and also ..
  81. ncbi Cues for apoptotic cell engulfment: eat-me, don't eat-me and come-get-me signals
    Cynthia Grimsley
    Carter Immunology Center and the Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    Trends Cell Biol 13:648-56. 2003
    ..This review examines unique signals presented by apoptotic cells and the mechanisms by which phagocytes recognize and respond to these signals to orchestrate the selective and rapid removal of apoptotic cells...
  82. ncbi Virulence strategies for infecting phagocytes deduced from the in vivo transcriptional program of Legionella pneumophila
    Holger Bruggemann
    Unité de Génomique des Microorganismes Pathogènes and CNRS URA 2171, Paris, France
    Cell Microbiol 8:1228-40. 2006
    ..Analysis of a fliA (sigma28) deletion mutant identified genes coregulated with the flagellar regulon, including GGDEF/EAL regulators and factors that promote host cell entry and survival...
  83. pmc The efficiency of the translocation of Mycobacterium tuberculosis across a bilayer of epithelial and endothelial cells as a model of the alveolar wall is a consequence of transport within mononuclear phagocytes and invasion of alveolar epithelial cells
    Luiz E Bermudez
    Kuzell Institute for Arthritis and Infectious Diseases, California Pacific Medical Center Research Institute, University of California, San Francisco, California, USA
    Infect Immun 70:140-6. 2002
    ..We identified two potential mechanisms by which M. tuberculosis gains access to deeper tissues, by translocating across epithelial cells and by traveling into the blood vessels within monocytes...
  84. pmc Drosophila melanogaster is a genetically tractable model host for Mycobacterium marinum
    Marc S Dionne
    Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305, USA
    Infect Immun 71:3540-50. 2003
    ..Death was accompanied by widespread tissue damage. M. marinum initially proliferated inside the phagocytes of the fly; later in infection, bacteria were found both inside and outside host cells. Intracellular M...
  85. ncbi How group A Streptococcus circumvents host phagocyte defenses
    Laura A Kwinn
    Division of Pediatric Pharmacology and Drug Discovery, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA
    Future Microbiol 2:75-84. 2007
    ..Understanding the molecular basis of GAS phagocyte resistance may reveal novel therapeutic targets for treatment and prevention of invasive human infections...
  86. ncbi Evolution of the inflammatory response in vertebrates: fish TNF-alpha is a powerful activator of endothelial cells but hardly activates phagocytes
    Francisco J Roca
    Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, Murcia, Spain
    J Immunol 181:5071-81. 2008
    ..and different CC and CXC chemokines in endothelial cells, thus explaining the recruitment and activation of phagocytes observed in vivo in both species...
  87. pmc Voltage-gated proton channels find their dream job managing the respiratory burst in phagocytes
    Thomas E DeCoursey
    Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, Illinois, USA
    Physiology (Bethesda) 25:27-40. 2010
    ..The proton channel seems designed for efficient proton extrusion from cells. In phagocytes, it facilitates the production of reactive oxygen species by NADPH oxidase.
  88. ncbi Neuroimmunity of HTLV-I Infection
    Eiji Matsuura
    Viral Immunology Section, Neuroimmunology Branch, NIH, Building 10, Room 5C 103, Bethesda, MD 20892, USA
    J Neuroimmune Pharmacol 5:310-25. 2010
    ..Here, we review pathophysiological findings on HAM/TSP and focus on viral-host immune responses to the virus in HTLV-I infected individuals. In particular, the role of HTLV-I-specific CD8+ T cell response is highlighted...
  89. pmc Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans
    Judith Behnsen
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
    PLoS Pathog 3:e13. 2007
    ..Live imaging shows that the interaction of phagocytes with Aspergillus or Candida in 2-D liquid cultures or 3-D collagen environments is a dynamic process that ..
  90. ncbi Effects of hypothermia and hyperthermia on cytokine production by cultured human mononuclear phagocytes from adults and newborns
    K D Fairchild
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 20201, USA
    J Interferon Cytokine Res 20:1049-55. 2000
    ..Hypothermia, on the other hand, may worsen outcome in infections by delaying and prolonging cytokine production...
  91. ncbi Transepithelial pathogen uptake into the small intestinal lamina propria
    Alexandra Vallon-Eberhard
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Immunol 176:2465-9. 2006
    ..underlies and stabilizes the gut lining epithelium is densely populated with strategically located mononuclear phagocytes. Collectively, these lamina propria macrophages and dendritic cells (DC) are believed to be crucial for tissue ..
  92. ncbi Clearance of dying autophagic cells of different origin by professional and non-professional phagocytes
    G Petrovski
    Department of Biochemistry, Apoptosis and Genomics Research Group of the Hungarian Academy of Sciences, Biophysics and Cell Biology, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary
    Cell Death Differ 14:1117-28. 2007
    ..Gene expression profiling showed that though both types of phagocytes expressed full repertoire of the PS recognition and signaling pathway, macrophages could evolve during ..
  93. pmc Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis
    Christopher P Baran
    Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Dorothy M Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio 43210, USA
    Am J Respir Crit Care Med 176:78-89. 2007
    An increase in the number of mononuclear phagocytes in lung biopsies from patients with idiopathic pulmonary fibrosis (IPF) worsens prognosis...
  94. ncbi Mechanisms of immune evasion in fungal pathogens
    John R Collette
    Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, 6431 Fannin St, Houston, TX 77030, United States
    Curr Opin Microbiol 14:668-75. 2011
    ..For the most part, the molecular mechanisms behind these behaviors are not yet known. This review discusses recent discoveries and insights into how fungi manipulate the host-pathogen interaction...
  95. ncbi Determining the role of mononuclear phagocytes in prion neuroinvasion from the skin
    Gwennaelle J Wathne
    University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
    J Leukoc Biol 91:817-28. 2012
    ..Therefore, together, these data suggest that the propagation of prions from the skin to the draining LN occurs via dermal classical DCs, independently of langerin(+) cells...
  96. ncbi Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cells
    Martin Vejrazka
    Institute of Medical Biochemistry, 1st Faculty of Medicine, Charles University, Katerinska 32, 121 08 Prague 2, Czech Republic
    Biochim Biophys Acta 1722:143-7. 2005
    ..Apocynin pre-activated with H2O2 and horseradish peroxidase (HRP) inhibited ROS production immediately. In non-phagocytes, apocynin stimulated ROS production and no inhibition was observed even after 60 min...
  97. ncbi Listeriosis in p47(phox-/-) and TRp55-/- mice: protection despite absence of ROI and susceptibility despite presence of RNI
    R Endres
    Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Federal Republic of Germany
    Immunity 7:419-32. 1997
    ..Despite activation of these antibacterial effector systems, TRp55-/- phagocytes in vivo are incapable of confining and eradicating L. monocytogenes inside phagolysosomes...
  98. ncbi Crawling phagocytes recruited in the brain vasculature after pertussis toxin exposure through IL6, ICAM1 and ITGαM
    Jean François Richard
    Department of Endocrinology and Genomics, Laval University Hospital Research Center, Quebec City, Quebec, Canada
    Brain Pathol 21:661-71. 2011
    ..We also found that phagocytes adhere to brain capillaries through the interaction of integrin αM (ITGαM) with ICAM1 and an unidentified ..
  99. ncbi Tuning the immune response of dendritic cells to surface-assembled poly(I:C) on microspheres through synergistic interactions between phagocytic and TLR3 signaling
    Annina M Hafner
    Institute of Pharmaceutical Sciences, ETH Zurich, Zurich 8093, Switzerland
    Biomaterials 32:2651-61. 2011
    ..Overall, phagocytic signaling plays an important role in defining the resulting immune response to such two-in-one adjuvant formulations...
  100. ncbi Infiltration of tumours by macrophages and dendritic cells: tumour-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Novartis Found Symp 256:137-45; discussion 146-8, 259-69. 2004
    Macrophages and dendritic cells infiltrate tumours. In the tumour microenvironment, mononuclear phagocytes acquire properties of polarized M2 (or alternatively activated) macrophages...
  101. pmc Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase
    S Ehrt
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, NY 10021, USA
    J Exp Med 194:1123-40. 2001
    ....

Research Grants71

  1. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ..to resist killing by reactive oxygen species (ROS) formed either by reduction of atmospheric oxygen or by phagocytes upon activation of the host inflammatory response...
  2. Trichothecene Toxicity and the Ribotoxic Stress Response
    James J Pestka; Fiscal Year: 2012
    ..of multiple intracellular signaling cascades that drive altered gene expression and apoptosis in mononuclear phagocytes in response to ribotoxic agents...
  3. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2011
    ..macrophage activation limits immunopathology Macrophages (MF) form a heterogeneous population of mononuclear phagocytes necessary for organ homeostasis, host defense, and immunoregulation...
  4. Novel Peptide MPO Inhibitors for Treating Atherosclerosis
    Kirkwood A Pritchard; Fiscal Year: 2012
    ..MPO is highly expressed in inflammatory phagocytes and is considered to play an important role in host defense mechanisms...
  5. Global regulatory interactions in bacterial pathogenesis
    BRIAN AKERLEY; Fiscal Year: 2009
    ..tissue or during late stages of respiratory infection in which levels of complement and numbers of activated phagocytes are increased in comparison to those at the normal airway surface...
  6. Maternal Autoantibodies: Pathogenesis of Neonatal Lupus
    JILL PAMELA BUYON; Fiscal Year: 2013
    ..That this perturbation of physiologic efferocytosis diverts uptake to professional Fc3R-bearing phagocytes fits well with ongoing experiments demonstrating macrophage secretion of pro-inflammatory and fibrosing ..
  7. Nanomedicine and NeuroAIDS
    Howard E Gendelman; Fiscal Year: 2013
    ..Novel strategies are sought for improved ART delivery to mononuclear phagocytes (MP: monocytes, perivascular and tissue macrophages and microglia) to bring drugs to tissue viral reservoirs...
  8. Group B. Streptococci and Toll-like Receptors
    Douglas T Golenbock; Fiscal Year: 2012
    ..The overall goal of this proposal is to better define the interphase between GBS and phagocytes with respect to GBS recognition and subsequent regulation of the inflammatory response in order to prepare ..
  9. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2013
    ..LOS structural genes involved in evasion of the complement (C) pathway, which targets NTHi for destruction by phagocytes. We have also found metabolic pathways critical for NTHi survival in the lung and depletion of neutrophils ..
  10. COCHLEAR MACROPHAGES AND EPITHELIAL REPAIR
    Keiko Hirose; Fiscal Year: 2013
    ..In prior work, we have demonstrated that hair cell injury evokes a strong, rapid recruitment of professional phagocytes in the form of monocytes and macrophages into the mouse cochlea...
  11. Dysregulation of the inflammatory response by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2013
    ..escape the phagosome and replicate in neutrophil cytosol, confirming its ability to successfully infect multiple phagocytes types. Particularly relevant here is our discovery of PMN-specific aspects of virulence...
  12. Pharmacology of Antiretroviral Nanoparticle Micelles
    Christopher J Destache; Fiscal Year: 2010
    ..Mononuclear phagocytes serve as not only as early reservoirs but also vehicles for dissemination for HIV-1...
  13. Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicity
    Tanya N Mayadas; Fiscal Year: 2013
    ..our understanding of the molecular basis of phagocyte cytotoxicity focusing on two major opsonic receptors on phagocytes, Fc?Rs (receptors for IgG immune complex) and the [unreadable]2 integrin Mac-1 (receptor for complement fragment ..
  14. Histoplasma Gene Expression and Organism Persistence
    ALAN GEORGE SMULIAN; Fiscal Year: 2012
    ..studies will determine if the failure to establish latency is due to altered trafficking within populations of phagocytes, due to an inability to disseminate, or due to failure to modulate the immune response...
  15. Iron Acquisition by Mycobacterium tuberculosis Within Phagocytes
    Bradley E Britigan; Fiscal Year: 2013
    ..Thus, increased understanding of how M. tuberculosis acquires and uses Fe during infection could lead to the development of new antibiotics to be used in treating TB, something that would be of great benefit to veterans. ..
  16. Diesel Exhaust Particle Effects on Human Immunity to Mycobacterium tuberculosis
    Stephan K Schwander; Fiscal Year: 2010
    ..PARAGRAPH] We have novel preliminary data that indicate that human blood phagocytes take up both M.tb and DEP. During simultaneous addition of DEP and M.tb, M...
  17. Novel Approach to Oral Gene Therapy for Chronic Granulomatous Disease
    Peter E Newburger; Fiscal Year: 2010
    ..in expression of the wild type gene encoding normal gp91-phox and correction of the functional defect in CGD phagocytes. Specifically, we propose to: 1...
  18. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2011
    ..LOS structural genes involved in evasion of the complement (C) pathway, which targets NTHi for destruction by phagocytes. We have also found metabolic pathways critical for NTHi survival in the lung and depletion of neutrophils ..
  19. Boosting Innate Immunity Through HIF to Treat Antibiotic-Resistant Infections
    ROBERT ALAN SHALWITZ; Fiscal Year: 2013
    ..boost HIF-1 in human phagocytes and cause them to kill pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) with efficiency ..
  20. Mechanisms of trauma and hemorrhage-induced impairment of innate immunity
    Xiao Di Tan; Fiscal Year: 2013
    ..e. trauma and hemorrhage) suppress innate immune function in non-phagocytes. This work will expand our knowledge on understanding and treatment of suppression of innate immunity in ..
  21. Oxidative Burst in Influenza and MRSA Co-infection
    Keer Sun; Fiscal Year: 2013
    ..NADPH oxidase 2 (NOX2) is an enzyme complex predominantly expressed by phagocytes. NOX2 produces superoxide which reacts with nitric oxide and results in the formation of highly toxic ..
  22. Pathophysiology and potential therapy for a childhood neurodegenerative disease
    Marquis T Walker; Fiscal Year: 2011
    ..Aim one is to test the hypothesis that the hematopoietic phagocytes in the TRPML1-/- mice are defective in endocytosis and lysosomal dependent degradation...
  23. Effects of apoptotic epithelial cell engulfment on mucosal inflammation
    Peter B Ernst; Fiscal Year: 2010
    ..the top of the gland or villous, epithelial cells die and either slough into the lumen or get engulfed by phagocytes within the lamina propria...
  24. Modular Subunit Vaccine for Salmonella
    MARC KEVIN JENKINS; Fiscal Year: 2011
    ..enterica serovar Typhimurium (ST) in mouse strains that naturally develop a persistent asymptomatic infection of phagocytes that is similar to the carrier state in humans...
  25. Immunobiology of Bacillus anthracis Spore-Host Interactions
    JOHN FRANKLIN KEARNEY; Fiscal Year: 2012
    ..by a combination of flow cytometric analysis and biochemical analysis using in vitro cells lines and primary phagocytes. If we can induce passive protective immunity with antibodies, we will attempt to elicit similar vaccine-induced ..
  26. FUNCTIONAL HIERARCHY OF REMNANT LIPOPROTEIN RECEPTORS
    Sergio Fazio; Fiscal Year: 2013
    ..severe pattern of macrophage apoptosis with a deficit in the internalization of apoptotic bodies by viable phagocytes. An effect unique to LRP1 was noted on the induction of inflammatory responses, as mice carrying LRP1-/- ..
  27. Innate immunity in Rett pathology and repair
    Jonathan Kipnis; Fiscal Year: 2013
    ..In irradiated mice, newly- engrafted brain mononuclear phagocytes produced high levels of insulin-like growth factor 1 (IGF-1), unlike resident mutant microglia, possibly one ..
  28. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2012
    ..We will examine if phagocytes or T cells or both produce one or more of these cytokines...
  29. HIV-1 regulation by MTb: pathogen and host factor
    Anne Goldfeld; Fiscal Year: 2010
    ..is initiated by the pathogen binding to host cells and signaling through several receptors found in mononuclear phagocytes, including the pattern recognition receptors (PRRs) TLR2, TLR4, and TLR9, and the interleukin (IL)-1 receptor...
  30. MECHANISMS OF SALMONELLA INVASION AND TRANSMIGRATION
    James E Casanova; Fiscal Year: 2013
    ..However, Salmonella can also use phagocytes as vehicles for their systemic dissemination, and the success or failure of the host response lies in the ..
  31. Genes Mediating Innate Immune Suppression by Hypercapnia in Mammals and Flies
    PETER H SPORN; Fiscal Year: 2013
    ..orthologs of these genes mediate hypercapnic suppression of innate immune/host defense genes in mouse and human phagocytes. In the case of Zfh2 and its mammalian orthologs, ZFHX3 and ZFHX4, we further hypothesize that hypercapnia ..
  32. Inflammasome activation by a respiratory virus
    Christopher M Wiethoff; Fiscal Year: 2010
    ..Release of these cytokines by macrophages at the site of viral infection recruits additional phagocytes and directs the quality and quantity of the adaptive immune response...
  33. Age-associated Toll-like receptor dysfunction in the lungs
    Carlos J Orihuela; Fiscal Year: 2010
    ..g. NFkB activation, cytokine production). It is now evident that aging is associated with TLR dysfunction;phagocytes isolated from aged animals exhibit decreased TLR expression, impaired TLR signaling, and a reduction in TLR-..
  34. Innate immune suppression following experimental injury
    KRISTIN C GREATHOUSE; Fiscal Year: 2012
    ..Therefore, the objectives of the research training proposal are: 1) to characterize innate immune functions of phagocytes against known nosocomial pathogens;2) to evaluate the effects of GM-CSF on the antimicrobial functions of ..
  35. REGULATION OF ACTIN FILAMENT FORMATION IN PHAGOCYTES
    Frederick Southwick; Fiscal Year: 2010
    ..CapG is expressed in phagocytes at far higher concentrations than required to regulate actin assembly, raising the possibility that CapG may ..
  36. The role of cochlear pericytes in control of cochlear microcirculation
    Xiao Rui Shi; Fiscal Year: 2009
    ..will investigate the pericyte (smooth muscle-like cells and also a progenitor cell to generate macrophages and phagocytes, fibroblasts, and smooth muscle cells) related regulatory mechanisms of cochlear microcirculation and gain a ..
  37. Inhibition of Anthrax Lethal Factor by alpha-defensins
    Wuyuan Lu; Fiscal Year: 2011
    ..the mitogen-activated protein kinase kinase (MAPKK) family, blocking the MARK signaling pathway in professional phagocytes. The binary complex of PA and LF alone, termed lethal toxin or LeTx, is sufficient to nduce death of target ..
  38. Non-oxidative Resistance to A. fumigatus by Alveolar Macrophages
    James B Burritt; Fiscal Year: 2010
    ..Alveolar macrophages (AM) are phagocytes known to be important in the early innate defense against A...
  39. Bioluminescence Imaging of Atherosclerosis Associated Reactive Oxygen Species
    REECE JOSEPH GOIFFON; Fiscal Year: 2013
    ..L-012 emit harmless, visible-spectrum light upon contact with reactive oxygen species (ROS) produced by phagocytes. These phagocytes are enriched in the arterial walls of CVD patients, mainly in and around inflamed plaques, and ..
  40. KIDNEY INJURY MOLECULE-1 IN EPITHELIAL REPAIR
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2013
    ..We have discovered that KIM-1 transforms kidney epithelial cells into semiprofessional phagocytes making it the first nonmyeloid phosphatidylserine receptor...
  41. Cell-mediated protection against pneumonic plague
    Jr Shiuan Lin; Fiscal Year: 2013
    ..virulence of Yp results, in large part, from plasmid-encoded factors that dampen inflammation and debilitate phagocytes, thereby compromising cell-mediated defense...
  42. PATHOGENIC MECHANISMS OF CUTANEOUS LEISHMANIASIS
    Lynn Soong; Fiscal Year: 2012
    ..strategies utilized by this and other vesicle-dwelling pathogens for growth within the hostile environment of phagocytes, and aid in designing comprehensive approaches for the control of Leishmania and other intracellular infections ..
  43. Quorum sensing-dependent interactions with biofilms and innate immunity defenses
    Alexander R Horswill; Fiscal Year: 2012
    ..aureus escape from non-phagocytic cells. Whether a similar mechanism occurs with professional phagocytes, such as polymorphonuclear leukocytes (PMN), is not clear...
  44. Identification of Pathways that Regulate Fibrosis through Collagen Resorption
    Kamran Atabai; Fiscal Year: 2012
    ..Drosophila S2 cells are macrophage-like phagocytes that are highly susceptible to gene silencing with double-stranded RNA...
  45. Oxidative Injury to Gastric Epithelial Cells by H. pylori
    Sheila E Crowe; Fiscal Year: 2013
    ..In response to infection, phagocytes recruited to the gastric mucosa, become activated and generate reactive oxygen species (ROS) and H...
  46. CNS Delivery of Activated Antiviral Drugs with Reduced Neurotoxicity (Nano-NRTIs)
    Serguei V Vinogradov; Fiscal Year: 2013
    ..drug delivery across the BBB would provide efficient drug access to HIV-1-bearing peripheral or brain-harboring phagocytes. We have developed novel stable drug nanoformulations (Nano-NRTI), which can suppress virus multiplication more ..
  47. Platelet Activating Factor, Synaptic Failure &NeuroAIDS
    Harris A Gelbard; Fiscal Year: 2013
    ..that model HAND in mouse cortex, using transgenic animals with fluorescently labeled neurons and/or mononuclear phagocytes. We propose three specific aims using HIV-1 Tat and its downstream effector, PAF, to induce changes in immune ..
  48. Eosinophil Peroxidase in Allergic Inflammation
    Arne Slungaard; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Eosinophil (EO) phagocytes can damage host tissue and contribute to the pathogenesis of allergic inflammatory diseases such as asthma and inflammatory bowel diseases (IBD)...
  49. A Role for Melanoregulin in RPE-mediated Phagocytosis
    KATHLEEN B BOESZE BATTAGLIA; Fiscal Year: 2010
    ..provided by applicant): Central to the retinal pigment epithelial cells'(RPE)1 role as professional phagocytes is the regulated biogenesis and maturation of lysosomes which serves as the major degrading compartment, ..
  50. The Role of Mfge8 and Apoptotic Cell Clearance in Regulating Asthma Severity
    Kamran Atabai; Fiscal Year: 2010
    ..b>Phagocytes secrete anti-inflammatory cytokines with key immune dampening roles in asthma after engulfing apoptotic cells by ..
  51. Bax function in apoptosis
    DONALD DAVID NEWMEYER; Fiscal Year: 2013
    ..The end result is that cells are actively dismantled and then consumed and destroyed by other cells called phagocytes. Our studies will use cell-free systems we have developed, using either artificial membranes or isolated outer ..
  52. Enhancing Pathogen-specific Memory CD8+ T cell Responses in Vivo
    GREGOIRE STEPHANE LAUVAU; Fiscal Year: 2013
    ..CCL3 secretion by protective memory CD8+ T cells promoted efficient recruitment and activation of phagocytes, specifically neutrophils and a distinct subset of monocytes known as "inflammatory monocytes", leading to ..
  53. The role of PhoP/PhoQ-regulated phospholipid alterations in Salmonella pathogenes
    ZACHARY DALEBROUX; Fiscal Year: 2013
    ..Here, typhoidal species traverse the intestinal epithelium and are ingested by resident phagocytes. Replication and survival within innate immune cells enable Salmonella to cause systemic disease...
  54. Mapping Lipid Oxidation in Traumatic Brain Injury by Mass Spectrometric Imaging
    Valerian E Kagan; Fiscal Year: 2013
    ..associated with mitochondrial stages of programmed cell death and recognition of damaged cells by professional phagocytes, respectively...
  55. The role of Nox2 in CNI-induced renal fibrosis
    Arjang Djamali; Fiscal Year: 2013
    ..We hypothesize that independent from its role in phagocytes, Nox2 is a key regulator of CNI-induced kidney hypoxia and fibrosis...
  56. Hematopoietic Stem Cell Differentiation to Macrophages
    E Richard Stanley; Fiscal Year: 2013
    ..Factor-1 (CSF-1) is the primary regulator of the survival, proliferation and differentiation of mononuclear phagocytes, including tissue macrophages and osteoclasts...
  57. Identification of novel genes as being important for neutrophil functions
    Dianqing Wu; Fiscal Year: 2013
    ..Unlike other phagocytes such as macrophages, primary differentiated neutrophils cannot be grown in culture for long and are not amenable ..
  58. Phagocyte Intoxication by ExoU in Pseudomonas Pneumonia
    ANGELICA ZHANG; Fiscal Year: 2013
    ..In the absence of ExoU, phagocytes successfully eradicate relatively low inocula of P...
  59. Fc receptor targeted therapy for immune hemolytic anemia
    Periasamy Selvaraj; Fiscal Year: 2009
    ..Abstract: Autoimmune hemolytic anemia (AIHA) is caused by the destruction of autoantibody-coated RBCs by phagocytes. Many studies have shown that the Fc[unreadable]Rs expressed on phagocytes play a vital role in binding and ..
  60. Proteogenomics of dysregulated protein interaction networks in MTB infection
    Mark R Chance; Fiscal Year: 2013
    ..The aims are: Aim 1: To determine dysregulated protein-protein interaction sub-networks in mononuclear phagocytes and CD4+ T cells of persons in households heavily exposed to MTB who do not become infected compared to those ..
  61. Immunopathogenesis of Spinal Tuberculosis (TB)
    Jilian A Sacks; Fiscal Year: 2013
    ..While in the circulation, infected phagocytes can disseminate throughout the body, leading to infection at extrapulmonary (EP) sites...
  62. 2011 Apoptotic Cell Recognition and Clearance Gordon Research Conference and Gord
    Adam Lacy-Hulbert; Fiscal Year: 2011
    ..Recent studies have revealed an additional role for engulfed apoptotic cells in the immune system. Phagocytes that have engulfed apoptotic cells regulate inflammation and promote resolution and tissue repair...
  63. MONONUCLEAR LEUKOCYTES AND IMMUNITY
    Samuel Silverstein; Fiscal Year: 2003
    We are studying monocular and polymorphonuclear phagocytes in infection and inflammation...
  64. Macrolide Accumulation by Host Cells in the Gingiva
    John D Walters; Fiscal Year: 2010
    ..actinomycetemomitans and P. gingivalis. The ability of these pathogens to invade epithelial cells and phagocytes makes them difficult to eliminate by conventional scaling and root planing alone...
  65. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..T cells exert a crucial role in host resistance by releasing cytokines that arm phagocytes to express anti-Hc activity...
  66. GP91-PHOX TRANSCRIPTION FACTORS AND HEMATOPOIESIS
    Elizabeth Eklund; Fiscal Year: 2000
    ..Expression of gp91-phox is restricted to terminally differentiated phagocytes and is increased by interferon gamma (IFN-g)...
  67. ANTIMICROBIAL EFFECT OF PEROXIDASE IN LEUKOCYTES
    SEYMOUR KLEBANOFF; Fiscal Year: 1999
    ..the properties, mechanism of action and biological significance the oxygen-dependent antimicrobial systems of phagocytes. Phagocytes respond to perturbation of the plasma membrane with a burst of oxygen consumption and extra oxygen ..
  68. REGULATION OF GRANULOCYTE AND MACROPHAGE PRODUCTION
    E Stanley; Fiscal Year: 2001
    Colony Stimulating Factor-1 (CSF-1) regulates the survival, proliferation and differentiation of mononuclear phagocytes that appear to play critical roles in the development and function of the tissues in which they reside...
  69. Peroxidase-Based Toxicity In Hypereosinophilic States.'
    Arne Slungaard; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Eosinophi1 (EO) phagocytes destroy parasites but can also damage host tissue...
  70. CR3 IN CELL ACTIVATION AND PHAGOCYTOSIS OF GONORRHEA
    ROBIN INGALLS; Fiscal Year: 2001
    ..efforts have focused on defining immunologic responses to protein antigens, studies would suggest that when phagocytes encounter Gram- negative bacteria, the subsequent cytokine response is due to the interactions of bacterial ..
  71. M AVIUM IMMUNE RESPONSES--IMPLICATIONS FOR THERAPY
    W Boom; Fiscal Year: 1999
    ..Host defense to MAC disease require both CD4+ T cells and monoculear phagocytes. Mononuclear phagocytes from HIV-infected persons perform equally well compared to HIV-uninfected persons when ..