myeloid progenitor cells

Summary

Summary: One of the two stem cells derived from HEMATOPOIETIC STEM CELLS - the other being the lymphoid progenitor cell. Derived from these myeloid progenitor cells are the ERYTHROID PROGENITOR CELLS and the MYELOID CELLS; (MONOCYTES and GRANULOCYTES).

Top Publications

  1. ncbi A map for lineage restriction of progenitors during hematopoiesis: the essence of the myeloid-based model
    Hiroshi Kawamoto
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Immunol Rev 238:23-36. 2010
  2. ncbi Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition
    Dingcheng Gao
    Department of Cardiothoracic Surgery and Neuberger Berman Lung Cancer Center, Weill Cornell Medical College of Cornell University, New York, New York, USA
    Cancer Res 72:1384-94. 2012
  3. pmc Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells
    Luoping Zhang
    School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
    Cancer Epidemiol Biomarkers Prev 19:80-8. 2010
  4. ncbi Transcription activation function of C/EBPalpha is required for induction of granulocytic differentiation
    Karen Keeshan
    Thomas Jefferson Medical College, Kimmel Cancer Institute, Philadelphia, PA 19107, USA
    Blood 102:1267-75. 2003
  5. ncbi Viral gene expression during the establishment of human cytomegalovirus latent infection in myeloid progenitor cells
    Allen K L Cheung
    Centre for Virus Research, Westmead Millennium Institute, PO Box 412, Westmead, NSW 2145, Australia
    Blood 108:3691-9. 2006
  6. ncbi Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy
    Cornelis J H Pronk
    Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, BMC I13, 221 84 Lund, Sweden Immunology Unit, Institution for Experimental Medical Science, Lund University, BMC I13, 221 84 Lund, Sweden
    Cell Stem Cell 1:428-42. 2007
  7. pmc Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation
    Anissa M Jabbour
    Children s Cancer Centre, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Vic, Australia
    Blood 115:344-52. 2010
  8. pmc Heterozygous kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic stem cell function
    Yashoda Sharma
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Exp Hematol 35:214-220. 2007
  9. pmc The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages
    Hiromi Iwasaki
    Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan
    Genes Dev 20:3010-21. 2006
  10. ncbi Analysis of leukemia-specific aneuploidies in cultured myeloid progenitor cells in the absence and presence of formaldehyde exposure
    Stefanie Kuehner
    Institut fur Humangenetik, Universitat Ulm, D 89081 Ulm, Germany
    Toxicol Sci 128:72-8. 2012

Detail Information

Publications216 found, 100 shown here

  1. ncbi A map for lineage restriction of progenitors during hematopoiesis: the essence of the myeloid-based model
    Hiroshi Kawamoto
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Immunol Rev 238:23-36. 2010
    ..The validity of the myeloid-based model of hematopoiesis will be discussed in reference to these two issues, developmental potential and cell fate...
  2. ncbi Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition
    Dingcheng Gao
    Department of Cardiothoracic Surgery and Neuberger Berman Lung Cancer Center, Weill Cornell Medical College of Cornell University, New York, New York, USA
    Cancer Res 72:1384-94. 2012
    ..models of spontaneous breast cancer, we show enhanced recruitment of bone marrow-derived CD11b(+)Gr1(+) myeloid progenitor cells in the premetastatic lungs...
  3. pmc Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells
    Luoping Zhang
    School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
    Cancer Epidemiol Biomarkers Prev 19:80-8. 2010
    ..Further, myeloid progenitor cells, the target for leukemogenesis, were cultured from the workers to quantify the level of leukemia-specific ..
  4. ncbi Transcription activation function of C/EBPalpha is required for induction of granulocytic differentiation
    Karen Keeshan
    Thomas Jefferson Medical College, Kimmel Cancer Institute, Philadelphia, PA 19107, USA
    Blood 102:1267-75. 2003
    ....
  5. ncbi Viral gene expression during the establishment of human cytomegalovirus latent infection in myeloid progenitor cells
    Allen K L Cheung
    Centre for Virus Research, Westmead Millennium Institute, PO Box 412, Westmead, NSW 2145, Australia
    Blood 108:3691-9. 2006
    ..associated with the establishment of latency, we tracked the virus following infection of primary human myeloid progenitor cells at days 1, 2, 3, 5, and 11...
  6. ncbi Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy
    Cornelis J H Pronk
    Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, BMC I13, 221 84 Lund, Sweden Immunology Unit, Institution for Experimental Medical Science, Lund University, BMC I13, 221 84 Lund, Sweden
    Cell Stem Cell 1:428-42. 2007
    ....
  7. pmc Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation
    Anissa M Jabbour
    Children s Cancer Centre, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Vic, Australia
    Blood 115:344-52. 2010
    ..Thus, we conclude that p53 protein is activated after IL-3 deprivation by loss of MDM2. Activated p53 transcriptionally up-regulates Puma, which initiates apoptosis...
  8. pmc Heterozygous kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic stem cell function
    Yashoda Sharma
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Exp Hematol 35:214-220. 2007
    ..This study tests how each mutation affects HSC function...
  9. pmc The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages
    Hiromi Iwasaki
    Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan
    Genes Dev 20:3010-21. 2006
    ..We propose that the order of expression of key transcription factors is critical for their interplay to selectively drive lineage specification programs, by which stem cells could generate multiple lineage cells in a hierarchical manner...
  10. ncbi Analysis of leukemia-specific aneuploidies in cultured myeloid progenitor cells in the absence and presence of formaldehyde exposure
    Stefanie Kuehner
    Institut fur Humangenetik, Universitat Ulm, D 89081 Ulm, Germany
    Toxicol Sci 128:72-8. 2012
    ..FA) at the workplace might induce leukemia-specific aneuploidies (monosomy 7 and trisomy 8) in cultured myeloid progenitor cells. Despite its preliminary character, this study was considered by the International Agency for Research on ..
  11. ncbi Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment
    Jörgen Adolfsson
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology, Lund University, Sweden
    Cell 121:295-306. 2005
    ..Based on these observations, we propose a revised road map for adult blood lineage development...
  12. ncbi The hematopoietic stem cell in chronic phase CML is characterized by a transcriptional profile resembling normal myeloid progenitor cells and reflecting loss of quiescence
    I Bruns
    Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine University Dusseldorf, Duesseldorf, Germany
    Leukemia 23:892-9. 2009
    ..Based on our findings we propose a loss of quiescence of the CML HSC on detachment from the niche leading to expansion of myeloid progenitors...
  13. ncbi A role for proapoptotic BID in the DNA-damage response
    Sandra S Zinkel
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 122:579-91. 2005
    ..We further demonstrate that this role is mediated through BID phosphorylation by the DNA-damage kinase ATM. These results establish a link between proapoptotic Bid and the DNA-damage response...
  14. pmc Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
    Antonio Cozzio
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Genes Dev 17:3029-35. 2003
    ....
  15. ncbi The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells
    Jurgen A F Marteijn
    Central Hematology Laboratory, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood 106:4114-23. 2005
    ..We conclude that proteasomal degradation of proteins that are ubiquitinated by Triad1 affects the clonogenic growth of primary myeloid progenitor cells.
  16. pmc Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells
    V Bronte
    Department of Oncology and Surgical Sciences, Padua University, Padova, Italy
    Blood 96:3838-46. 2000
    ..Blood. 2000;96:3838-3846)..
  17. pmc Fas-associated phosphatase 1 (Fap1) influences βcatenin activity in myeloid progenitor cells expressing the Bcr-abl oncogene
    Weiqi Huang
    Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, USA
    J Biol Chem 288:12766-76. 2013
    ..We found previously that expression of the CML-related Bcr-abl oncoprotein in myeloid progenitor cells increases expression of Fas-associated phosphatase 1 (Fap1)...
  18. pmc The leukemia-associated Mll-Ell oncoprotein induces fibroblast growth factor 2 (Fgf2)-dependent cytokine hypersensitivity in myeloid progenitor cells
    Chirag A Shah
    From The Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois 60611 and
    J Biol Chem 288:32490-505. 2013
    ..Fgf2 influences proliferation and survival of hematopoietic stem cells and myeloid progenitor cells, and increased Fgf2-expression has been described in AMLs...
  19. ncbi Graft-versus-leukemia target antigens in chronic myelogenous leukemia are expressed on myeloid progenitor cells
    Catherine J Wu
    Division of Hematologic Malignancies, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Cancer Res 11:4504-11. 2005
    ..The present studies characterize expression of CML28 and CML66 in primary hematopoietic tissues...
  20. pmc Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10
    Kevin Oakley
    Department of Pediatrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Blood 119:6099-108. 2012
    ..Thus, Setbp1 activation represents a novel mechanism conferring self-renewal capability to myeloid progenitors in myeloid leukemia development...
  21. ncbi Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity
    J Adolfsson
    Department of Stem Cell Biology, Institute of Laboratory Medicine, University Hospital of Lund, S-221 85 Lund, Sweden
    Immunity 15:659-69. 2001
    ..Thus, upregulation of flt3 expression on Lin(-)Sca1(+)c-kit(+) HSC cells is accompanied by loss of self-renewal capacity but sustained lymphoid-restricted reconstitution potential...
  22. ncbi Induction of an IL7-R(+)c-Kit(hi) myelolymphoid progenitor critically dependent on IFN-gamma signaling during acute malaria
    Nikolai N Belyaev
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London, UK
    Nat Immunol 11:477-85. 2010
    ..Thus, IFN-gamma is a key modulator of hematopoiesis and innate and adaptive immunity during acute malaria infection...
  23. pmc C/EBPalpha directs monocytic commitment of primary myeloid progenitors
    Dehua Wang
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA
    Blood 108:1223-9. 2006
    ..A C/EBPalpha variant incapable of zippering with c-Jun did not induce monopoiesis, and a variant unable to bind NF-kappaB p50 stimulated granulopoiesis, suggesting their cooperation with C/EBPalpha during monocytic commitment...
  24. ncbi Uncaria tomentosa extract increases the number of myeloid progenitor cells in the bone marrow of mice infected with Listeria monocytogenes
    Samara Eberlin
    Departamento de Farmacologia Hemocentro, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas UNICAMP, C P 6111, CEP 13083 970, Campinas, SP, Brazil
    Int Immunopharmacol 5:1235-46. 2005
    ....
  25. ncbi Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions
    Venkateshwar A Reddy
    Department of Medicine III, Ludwig Maximilians University and GSF National Research Center for Environment and Health, Munich, Germany
    Blood 100:483-90. 2002
    ..The functional blocking of PU.1 by C/EBPalpha could be the mechanism by which C/EBPalpha inhibits cell fates specified by PU.1 and directs cell development to the granulocyte lineage...
  26. ncbi Heterogeneous expression pattern of pro- and anti-apoptotic factors in myeloid progenitor cells of patients with severe congenital neutropenia treated with granulocyte colony-stimulating factor
    Gunnar Cario
    Department of Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany
    Br J Haematol 129:275-8. 2005
    Apoptosis is accelerated in the myeloid progenitor cells of patients with severe congenital neutropenia (CN). Granulocyte colony-stimulating factor (G-CSF) increases neutrophil numbers in most CN patients...
  27. ncbi TLS-ERG leukemia fusion protein deregulates cyclin-dependent kinase 1 and blocks terminal differentiation of myeloid progenitor cells
    Jing Pan
    Departments of Orthopedics and Medicine Hematology, University of Washington, 1660 South Columbian Way, GMR 151, Seattle, WA 98108
    Mol Cancer Res 6:862-72. 2008
    ..Here, we show that retroviral transduction of TLS-ERG confers a growth advantage to L-G myeloid progenitor cells and blocks terminal differentiation...
  28. pmc Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors
    Craig D Jude
    Department of Genetics and Norris Cotton Cancer Center, Dartmouth Medical School, 725 Remsen, HB7400, Hanover, NH 03755, USA
    Cell Stem Cell 1:324-37. 2007
    ..These studies demonstrate that Mll plays selective and independent roles within the hematopoietic system, maintaining quiescence in HSCs and promoting proliferation in progenitors...
  29. ncbi The nuclear orphan receptor TR4 promotes proliferation of myeloid progenitor cells
    N P Koritschoner
    Max Delbruck Center for Molecular Medicine, D 13122 Berlin, Germany
    Cell Growth Differ 12:563-72. 2001
    ..TR4, when ectopically expressed in bone marrow cells via retrovirus vector, promotes proliferation of myeloid progenitor cells. Cells represent promyelocytes as judged by morphological features, expression of cell surface molecules, ..
  30. ncbi Analysis of expansion of myeloid progenitors in mice to identify leukemic susceptibility genes
    Vincent E Sollars
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, Pennsylvania 19107, USA
    Mamm Genome 17:808-21. 2006
    ..Given the importance of this cell compartment in leukemia progression and the soon to be released genomic sequence of 15 mouse strains, these differences may provide a valuable tool for research into leukemia...
  31. pmc Cytomegalovirus MCK-2 controls mobilization and recruitment of myeloid progenitor cells to facilitate dissemination
    Satoshi Noda
    Department of Microbiology and Immunology, Stanford University School of Medicine, Fairchild Science Bldg, 299 Campus Dr, Stanford, CA 94305 5124, USA
    Blood 107:30-8. 2006
    ..Mobilization influences levels of virus dissemination via the bloodstream to salivary glands and is dependent on a myelomonocytic cell type other than mature macrophages...
  32. ncbi Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets
    D Traver
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Blood 98:627-35. 2001
    ..Blood. 2001;98:627-635)..
  33. ncbi GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages
    Hiromi Iwasaki
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Immunity 19:451-62. 2003
    ..Thus, GATA-1 specifically instructs MegE commitment while excluding other fate outcomes in stem and progenitor cells, suggesting that regulation of GATA-1 is critical in maintaining multilineage homeostasis...
  34. pmc The pattern of gene expression in human CD15+ myeloid progenitor cells
    S Lee
    Department of Medicine, University of Chicago Medical Center, 5841 South Maryland, MC2115, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 98:3340-5. 2001
    We performed a genome-wide analysis of gene expression in primary human CD15(+) myeloid progenitor cells. By using the serial analysis of gene expression (SAGE) technique, we obtained quantitative information for the expression of 37,519 ..
  35. ncbi Impaired granulocytopoiesis in patients with chronic idiopathic neutropenia is associated with increased apoptosis of bone marrow myeloid progenitor cells
    Helen A Papadaki
    Department of Hematology of the University of Crete School of Medicine and Institute of Molecular Biology and Biotechnology, Heraklion, Crete, Greece
    Blood 101:2591-600. 2003
    ..necrosis factor alpha and cytokine levels in culture supernatants inversely correlated with the number of myeloid progenitor cells and positively with the proportion of apoptotic CD34(+) cells...
  36. ncbi Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF-induced expansion of myeloid progenitor cells
    Mirjam H A Hermans
    Institute of Hematology, Erasmus University of Rotterdam, The Netherlands
    Blood 101:2584-90. 2003
    ..These findings suggest that tyrosines in the cytoplasmic domain of G-CSF-R, although dispensable for G-CSF-induced colony growth, recruit signaling mechanisms that regulate the maintenance and outgrowth of myeloid progenitor cells.
  37. ncbi Uncaria tomentosa stimulates the proliferation of myeloid progenitor cells
    Iria Farias
    Departamento de Quimica, Universidade Federal de Santa Maria, 97105 900 Santa Maria, RS, Brazil
    J Ethnopharmacol 137:856-63. 2011
    ....
  38. ncbi Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes
    Kristina Anderson
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Klinikgatan 26, 221 84 Lund, Sweden
    Blood 109:3697-705. 2007
    ..Along with the established ectopic expression of PAX5 in acute myeloid leukemia, this motivates a careful investigation of the potential involvement of ectopic PAX5 expression in myeloid and biphenotypic leukemias...
  39. ncbi Bmi1 is essential for leukemic reprogramming of myeloid progenitor cells
    J Yuan
    Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    Leukemia 25:1335-43. 2011
    ....
  40. ncbi Escherichia coli pneumonia enhances granulopoiesis and the mobilization of myeloid progenitor cells into the systemic circulation
    Lotfollah M Shahbazian
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Crit Care Med 32:1740-6. 2004
    ..The process by which hematopoietic tissues respond to a pulmonary infection remains poorly understood. This study investigated the potential role of lung-derived granulopoietic cytokines in facilitating this response...
  41. ncbi The interferon-inducible gene, Ifi204, is transcriptionally activated in response to M-CSF, and its expression favors macrophage differentiation in myeloid progenitor cells
    Jérémy Dauffy
    Centre de Genetique Moleculaire et Cellulaire, UMR CNRS 5534, Villeurbanne Cedex, France
    J Leukoc Biol 79:173-83. 2006
    ..Moreover, this study suggests that other members of the Ifi family might act as regulators of hematopoiesis under the control of hemopoietic cytokines...
  42. pmc Tumor-associated CD8+ T cell tolerance induced by bone marrow-derived immature myeloid cells
    Sergei Kusmartsev
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    J Immunol 175:4583-92. 2005
    ..Thus, this is a first demonstration that in tumor-bearing mice CD8+ T cell tolerance is induced primarily by ImC that may have direct implications for cancer immunotherapy...
  43. pmc E2A proteins promote development of lymphoid-primed multipotent progenitors
    Sheila Dias
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Immunity 29:217-27. 2008
    ..Our results reveal that E2A proteins play a critical role in supporting lymphoid specification from HSCs and that the reduced generation of LMPPs underlies the severe lymphocyte deficiencies observed in E2A-deficient mice...
  44. ncbi Signaling pathways implicated in hematopoietic progenitor cell proliferation and differentiation
    Diana Bugarski
    The Institute for Medical Research, Dr Subotica 4, 11129 Beograd, Serbia and Montenegro
    Exp Biol Med (Maywood) 232:156-63. 2007
    ....
  45. ncbi MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors
    Brian J P Huntly
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cancer Cell 6:587-96. 2004
    ..of leukemic stem cells, we tested the hypothesis that all leukemia oncogenes could transform committed myeloid progenitor cells lacking the capacity for self-renewal, as has recently been reported for MLL-ENL...
  46. pmc Asymmetrical lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors
    Anne Y Lai
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 203:1867-73. 2006
    ..Our results suggest that the first step of lineage commitment from HSCs is not simply a selection between the lymphoid and the myeloid lineage...
  47. ncbi Phenotype and hematopoietic potential of side population cells throughout embryonic development
    Brian M Nadin
    Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Blood 102:2436-43. 2003
    ....
  48. ncbi A new clonal assay system for lymphoid and myeloid lineages
    Hiroshi Kawamoto
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Methods Mol Med 105:345-58. 2005
    ..By examining cells from murine fetal tissues with this assay, we have succeeded in elucidating the process of lineage restrictions in early hematopoiesis...
  49. ncbi IL-3 induces inhibitor of DNA-binding protein-1 in hemopoietic progenitor cells and promotes myeloid cell development
    Wilairat Leeanansaksiri
    Basic Research Program, Science Applications International Corporation SAIC Frederick, National Cancer Institute Frederick, MD 21702, USA
    J Immunol 174:7014-21. 2005
    ..Enforced expression of Id1 in committed myeloid progenitor cells inhibits granulocyte but not macrophage differentiation...
  50. ncbi Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid pathway
    Michael K Richards
    Division of Oncology, Department of Medicine, 660 S Euclid Ave, Campus Box 8007, Saint Louis, MO 63110
    Blood 102:3562-8. 2003
    ..Thus, regulation of G-CSF levels may provide a mechanism for directing primitive hematopoietic progenitors into the common myeloid lineage in response to environmental stresses...
  51. ncbi Multitalented E2A: a new role in lymphoid-lineage priming
    Motonari Kondo
    Department of Immunology, Duke University Medical Center, 101 Jones Building, DUMC Box 3010, Research Drive, Durham, NC 27710, USA
    Immunity 29:169-70. 2008
    ..How do hematopoietic stem cells choose to be lymphocytes? In this issue of Immunity, Dias et al. (2008) uncover the requirement for E2A during lymphoid-lineage priming in the multipotent progenitor population...
  52. pmc Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation
    Brenda J Chyla
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Mol Cell Biol 28:6234-47. 2008
    ..Inactivation of Mtg16 skewed early myeloid progenitor cells toward the granulocytic/macrophage lineage while reducing the numbers of megakaryocyte-erythroid ..
  53. ncbi Transplantable cell lines generated with NUP98-Hox fusion genes undergo leukemic progression by Meis1 independent of its binding to DNA
    N Pineault
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada
    Leukemia 19:636-43. 2005
    ..The availability of lines with repopulating potential and capacity for leukemic conversion should open new avenues for understanding progression of Hox-mediated acute myeloid leukemia...
  54. ncbi Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival
    Yoshikane Kikushige
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Immunol 180:7358-67. 2008
    ....
  55. ncbi Bone marrow precursors of nonobese diabetic mice develop into defective macrophage-like dendritic cells in vitro
    Tatjana Nikolic
    Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
    J Immunol 173:4342-51. 2004
    ..Potentially, these anomalies contribute to the dysfunctional regulation of tolerance in NOD mice yet are insufficient to induce autoimmune diabetes because they occurred partly in NOR mice...
  56. ncbi Endothelial progenitor cells: characterization and role in vascular biology
    Carmen Urbich
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circ Res 95:343-53. 2004
    ..This review summarizes the mechanisms regulating endothelial progenitor cell-mediated neovascularization and reendothelialization...
  57. pmc Bone marrow norepinephrine mediates development of functionally different macrophages after thermal injury and sepsis
    Mitchell J Cohen
    Department of Physiology, The Burn and Shock Trauma Institute Loyola University Medical Center Maywood, Illinois, USA
    Ann Surg 240:132-41. 2004
    ....
  58. ncbi Cytokine expanded myeloid precursors function as regulatory antigen-presenting cells and promote tolerance through IL-10-producing regulatory T cells
    Kelli P A MacDonald
    Queensland Institute of Medical Research, Herston, Australia
    J Immunol 174:1841-50. 2005
    ..Thus, a population of cytokine-expanded GM precursors function as regulatory APCs, suggesting that G-CSF derivatives may have application in disorders characterized by a loss of self-tolerance...
  59. ncbi Defining the pathways of early adult hematopoiesis
    Cornelis Murre
    Division of Biological Sciences, 0366, University of California, San Diego, La Jolla, CA 92903, USA
    Cell Stem Cell 1:357-8. 2007
    ..In this issue of Cell Stem Cell, Arinobu et al. (2007) and Pronk et al. (2007) provide new insights into the paths traveled by hematopoietic progenitors...
  60. ncbi Sodium caseinate induces expression and secretion of murine multipotent myeloid cell line 32D macrophage colony-stimulating factor
    Gerardo Ramos
    Laboratorio de Biología Celular y Molecular del Cáncer L 324, Facultad de Estudios Superiores FES Zaragoza, Universidad Nacional Autonoma de Mexico, Calle Batalla 5 de Mayo s n, Mexico City, 09230 Mexico
    Arch Med Res 35:109-13. 2004
    ....
  61. ncbi Dendritic cell maturation requires STAT1 and is under feedback regulation by suppressors of cytokine signaling
    Sharon H Jackson
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:2307-15. 2004
    ....
  62. ncbi Deceptive multilineage reconstitution analysis of mice transplanted with hemopoietic stem cells, and implications for assessment of stem cell numbers and lineage potentials
    David Bryder
    Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
    J Immunol 172:1548-52. 2004
    ....
  63. ncbi HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo
    Neal A Fischbach
    Department of Medicine, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Blood 105:1456-66. 2005
    ..These biologic effects of HOXB6 were largely dependent on DNA binding but independent of direct interaction with PBX1...
  64. ncbi A dominant-negative mutant of C/EBPalpha, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse
    Maike Schwieger
    Molecular Pathology Group, Heinrich Pette Institut für Experimentelle Immunologie und Virologie, Hamburg, Germany
    Blood 103:2744-52. 2004
    ....
  65. ncbi Estradiol acts directly on bone marrow myeloid progenitors to differentially regulate GM-CSF or Flt3 ligand-mediated dendritic cell differentiation
    Esther Carreras
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Immunol 180:727-38. 2008
    ....
  66. ncbi Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation
    Michael J Nemeth
    Hematopoiesis Section, National Human Genome Research Institute, Bethesda, MD 20892 4442, USA
    Blood 102:1298-306. 2003
    ..We conclude that down-regulation of Hmgb3 protein levels is an important step for myeloid and B-cell differentiation...
  67. pmc Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy
    Matthew R Ritter
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Clin Invest 116:3266-76. 2006
    ..Using a model of oxygen-induced retinopathy, we demonstrate that a population of adult BM-derived myeloid progenitor cells migrated to avascular regions of the retina, differentiated into microglia, and facilitated normalization ..
  68. pmc The origin and in vivo significance of murine and human culture-expanded endothelial progenitor cells
    Emerson E Sharpe
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Am J Pathol 168:1710-21. 2006
    ..Taken together, the data suggest that the local neovascular microenvironment may facilitate vasculogenesis by promoting endothelial differentiation and that CE-EPCs may accelerate such vasculo-genesis...
  69. ncbi Notch1 perturbation of hemopoiesis involves non-cell- autonomous modifications
    Shin Kawamata
    SyStemix, Palo Alto, CA 94304, USA
    J Immunol 168:1738-45. 2002
    ..These findings indicate that modifications of neighboring cells through non-cell-autonomous modifications take part in multiple facets of the activity of Notch on hemopoiesis...
  70. ncbi Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish
    Benjamin M Hogan
    Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Curr Biol 16:506-11. 2006
    ..1 expression, but the role of alk8 was independent of the scl-dependent cell-fate pathway. Furthermore, the role of Alk8 in myelopoiesis was genetically separable from its earlier role in dorsal-ventral embryonic patterning...
  71. ncbi Murine dendritic cells derived from myeloid progenitors of the thymus are unable to produce bioactive IL-12p70
    C Martinon-Ego
    Laboratoire Immunochimie, , , , , , Grenoble, France
    J Immunol 166:5008-17. 2001
    ..The mechanisms underlying the differences in IL-12-secreting capacities of the cultured splenic and thymic DC are under current investigation...
  72. pmc Identification of CD13+CD36+ cells as a common progenitor for erythroid and myeloid lineages in human bone marrow
    Ling Chen
    Molecular and Clinical Hematology Branch MCHB, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Exp Hematol 35:1047-55. 2007
    ..To identify bipotential precursor cells of erythroid and myeloid development in human bone marrow...
  73. ncbi Effect of alcoholic extract of Ayurvedic herb Tinospora cordifolia on the proliferation and myeloid differentiation of bone marrow precursor cells in a tumor-bearing host
    Sukh Mahendra Singh
    School of Biotechnology, Banaras Hindu University, Varanasi 221 005, U P, India
    Fitoterapia 77:1-11. 2006
    ..This study indicates that the T. cordifolia can influence the myeloid differentiation of bone marrow progenitor cells and the recruitment of macrophages in response to tumor growth in situ...
  74. ncbi A clonogenic bone marrow progenitor specific for macrophages and dendritic cells
    Darin K Fogg
    INSERM, Laboratory of Mononuclear Phagocyte Biology, Avenir Team, Necker Enfants Malades Institute, 75015 Paris, France
    Science 311:83-7. 2006
    ..Thus, macrophages and DCs appear to renew from a common progenitor, providing a cellular and molecular basis for the concept of the MPS...
  75. ncbi Hematopoiesis of immature myeloid dendritic cells in stroma-dependent spleen long-term cultures occurs independently of NF-KB/RelB function
    Jonathan K H Tan
    School of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra, Australia
    Exp Hematol 35:1580-93. 2007
    ..Expression and function of RelB in development of LTC-DC has been investigated, with a view to assessing the relationship between DC produced in this system and other known subsets of DC...
  76. ncbi Mobilization of human lymphoid progenitors after treatment with granulocyte colony-stimulating factor
    Rie Imamura
    Blood Transfusion Service, Kyushu University Hospital, Fukuoka, Japan
    J Immunol 175:2647-54. 2005
    ..The results suggest that by acting through multiple trans-acting signals, G-CSF can mobilize not only myeloid-committed populations but a variety of resident marrow cell populations including lymphoid progenitors...
  77. pmc IGF-I increases bone marrow contribution to adult skeletal muscle and enhances the fusion of myelomonocytic precursors
    Alessandra Sacco
    Department of Molecular Pharmacology, Baxter Laboratory in Genetic Pharmacology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 171:483-92. 2005
    ..These results provide novel evidence that a single factor, IGF-I, is sufficient to enhance the fusion of bone marrow derivatives with adult skeletal muscle...
  78. pmc Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis
    Lesley F Drynan
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 24:3136-46. 2005
    ..Therefore, a permissive cellular environment is required for oncogenicity of Mll-associated translocations and Mll fusions can influence haematopoietic lineage commitment...
  79. ncbi Deregulated c-Myc prematurely recruits both Type I and II CD95/Fas apoptotic pathways associated with terminal myeloid differentiation
    Arshad Amanullah
    Fels Institute for Cancer Research, Temple University School of Medicine, 3307 N Broad Street, Philadelphia, Pennsylvania, PA 19140, USA
    Oncogene 21:1600-10. 2002
    ..Our findings offer important new insights into understanding how deregulated c-myc alters normal blood cell homeostasis, and how additional mutations might promote leukemogenesis...
  80. ncbi Increased generation of dendritic cells from myeloid progenitors in autoimmune-prone nonobese diabetic mice
    Raymond J Steptoe
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, 3050 Victoria, Australia
    J Immunol 168:5032-41. 2002
    ..We propose that an imbalance favoring development of DC from myeloid-committed progenitors predisposes to autoimmune disease in NOD mice...
  81. ncbi Developmental fate of hematopoietic stem cells: the study of individual hematopoietic clones at the level of antigen-responsive B lymphocytes
    Natalia I Olovnikova
    Hematological Scientific Centre, Moscow, Russia
    Hematol J 4:146-50. 2003
    ..These data establish that the stem cell compartment functions by continuously producing progeny, which fully but transiently repopulate all lineages...
  82. pmc The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation
    Mark W Feinberg
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 26:4138-48. 2007
    ..1-/- fetal liver cells along the monocytic lineage and can activate the monocytic-specific CD14 promoter. Thus, KLF4 is a critical regulator in the transcriptional network controlling monocyte differentiation...
  83. ncbi M-CSF: a novel plasmacytoid and conventional dendritic cell poietin
    Ben Fancke
    Research Department, Bavarian Nordic GmbH, Martinsried, Germany
    Blood 111:150-9. 2008
    ..It is noteworthy that using mice deficient in FL indicated that the M-CSF-driven generation of pDCs and cDCs in vitro and in vivo was independent of endogenous FL...
  84. ncbi JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms
    Jean Pierre David
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Cell Sci 115:4317-25. 2002
    ..Thus, these data provide genetic evidence that JNK1 activation modulates osteoclastogenesis through both c-Jun-phosphorylation-dependent and -independent mechanisms...
  85. ncbi The regulatory role of Hyper-IL-6 in the differentiation of myeloid and erythroid progenitors derived from human cord blood
    Zhaocai Yu
    Department of Clinical Oncology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    Cell Immunol 241:32-7. 2006
    ..Our results indicate that Hyper-IL-6 augments the generation of CD15(+) granulocytic, CD14(+) monocytic and CD36(+)glycophorinA(high) cell and suppresses that of CD14(-)CD1a(+) dendritic cells...
  86. pmc Generation of functionally distinct B lymphocytes from common myeloid progenitors
    G X Yang
    Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis, Davis, CA, USA
    Clin Exp Immunol 150:349-57. 2007
    ..Together, these data suggest the existence of multiple pathways for generating functionally distinct B cells from bone marrow precursors...
  87. ncbi Reconstitution of lethally irradiated adult mice with dominant negative TGF-beta type II receptor-transduced bone marrow leads to myeloid expansion and inflammatory disease
    Ali H Shah
    Department of Urology, Northwestern University Medical School, Chicago, IL 60611, USA
    J Immunol 169:3485-91. 2002
    ....
  88. ncbi Influence of lineage-specific cytokines on commitment and asymmetric cell division of haematopoietic progenitor cells
    Ling Chen
    Molecular and Clinical Hematology Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD 20892, USA
    Br J Haematol 118:847-57. 2002
    ....
  89. ncbi Src-family kinases play an essential role in differentiation signaling downstream of macrophage colony-stimulating factor receptors mediating persistent phosphorylation of phospholipase C-gamma2 and MAP kinases ERK1 and ERK2
    C Bourgin-Hierle
    Centre de Genetique Moleculaire et Cellulaire, Universite de Lyon, UMR 5534, Universite Claude Bernard Lyon 1, CNRS, Villeurbanne, France
    Leukemia 22:161-9. 2008
    ..The decision of myeloid progenitor cells to commit to differentiation depends on activation levels of the mitogen-activated protein kinases (MAPK),..
  90. ncbi Development of a murine hematopoietic progenitor complementary DNA microarray using a subtracted complementary DNA library
    Xianyong Ma
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Blood 100:833-44. 2002
    ..med.yale.edu/, allows for retrieval of information regarding these genes. Our microarray allows for genomewide expression analysis of myeloid stem cells, which will help in defining the regulatory mechanisms of stem cell differentiation...
  91. ncbi Differentiation-associated expression of two functionally distinct classes of granulocyte-macrophage colony-stimulating factor receptors by human myeloid cells
    S A Cannistra
    Division of Tumor Immunology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 265:12656-63. 1990
    ..are dependent upon the differentiation status of the myeloid cell and range from proliferation of early myeloid progenitor cells to activation of neutrophil and monocyte function...
  92. ncbi The role of JAK2 V617F mutation, spontaneous erythropoiesis and megakaryocytopoiesis, hypersensitive platelets, activated leukocytes, and endothelial cells in the etiology of thrombotic manifestations in polycythemia vera and essential thrombocythemia
    Sylvia Bellucci
    AP HP, Service d Hematologie Biologique, Hopital Lariboisiere, Denis Diderot, Faculte de Medecine, Paris, France
    Semin Thromb Hemost 32:381-98. 2006
    ..makes the normal hematopoietic progenitor cells hypersensitive to thrombopoietin, erythropoietin, and myeloid progenitor cells, leading to trilinear hematopoietic myeloproliferation...
  93. ncbi Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia
    F Dong
    Department of Hematology, Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    N Engl J Med 333:487-93. 1995
    In severe congenital neutropenia the maturation of myeloid progenitor cells is arrested. The myelodysplastic syndrome and acute myeloid leukemia develop in some patients with severe congenital neutropenia...
  94. ncbi Constitutive expression of the FK506 binding protein 51 (FKBP51) in bone marrow cells and megakaryocytes derived from idiopathic myelofibrosis and non-neoplastic haematopoiesis
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Eur J Haematol 72:239-44. 2004
    ..The knowledge of FKBP51 and its expression in bone marrow cells and mature megakaryocytes in non-neoplastic haematopoiesis and IMF is sparse...
  95. ncbi Toward the identification of mesenchymal stem cells in bone marrow and peripheral blood for bone regeneration
    Dennis Smiler
    Oral and Maxillofacial Surgeon, Encino, CA, USA
    Implant Dent 17:236-47. 2008
    ..Specific markers exist for cells related to bone healing and bone regeneration. These include but are not limited to hematopoietic, mesenchymal, endothelial, angiogenic, and vasculargenic precursor cells...
  96. ncbi Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia
    P F Bross
    Division of Oncology Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852, USA
    Clin Cancer Res 7:1490-6. 2001
    ..In this study, we review the preclinical and clinical profiles of this immunoconjugate and the regulatory review that led to marketing approval by the United States Food and Drug Administration...
  97. ncbi Aberrant expression of insulin-like growth factor-2 (IGF-2) in Philadelphia chromosome negative chronic myeloproliferative disorders
    Oliver Bock
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625, Germany
    Leuk Res 28:1145-51. 2004
    ..Paranuclear IGF-2 protein could be demonstrated in IMF, ET, and PV exclusively in megakaryocytes and myeloid progenitor cells in contrast to undetectable IGF-2 protein in control cases...
  98. pmc Regulation of surface expression of the granulocyte/macrophage colony-stimulating factor receptor in normal human myeloid cells
    S A Cannistra
    Division of Tumor Immunology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 87:93-7. 1990
    ..GM-CSF receptor expression in normal human neutrophils, monocytes, and partially purified bone marrow myeloid progenitor cells. The neutrophil GM-CSF receptor was found to rapidly internalize in the presence of ligand through a ..
  99. ncbi Decrease of circulating hematopoietic progenitor cells During interleukin-2 treatment is associated with an increase of vascular cell adhesion molecule-1, a critical molecule for progenitor cell adhesion
    G J Locker
    Department of Internal Medicine I, Division of Oncology, University Hospital of Vienna, Vienna, Austria
    Leuk Lymphoma 39:355-64. 2000
    ..Circulating myeloid progenitor cells (CFU-GM) dropped from a mean value of 167 +/- 187 / ml pre IL-2 to 16 +/- 15 / ml on day 3 (p < 0.01)...
  100. ncbi Bone marrow-derived cells require a functional glucose 6-phosphate transporter for normal myeloid functions
    So Youn Kim
    Section on Cellular Differentiation, Heritable Disorders Branch, NICHD, Molecular Signaling Section, Laboratory of Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:28794-801. 2006
    ..In the bone marrow of BM-Glc-6-PT(-/-) and Glc-6-PT(-/-) mice, the numbers of myeloid progenitor cells are increased, while in the serum there is an increase in granulocyte colony-stimulating factor and ..
  101. ncbi PU.1, interferon regulatory factor (IRF) 2, and the interferon consensus sequence-binding protein (ICSBP/IRF8) cooperate to activate NF1 transcription in differentiating myeloid cells
    Weiqi Huang
    The Feinberg School of Medicine and the Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 282:6629-43. 2007
    ..1-IRF2 heterodimer. NF1 deficiency in myeloid progenitor cells results in cytokine hypersensitivity and myeloproliferation...

Research Grants62

  1. ICSBP Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
    ..However, ICSBP-deficient myeloid progenitor cells exhibit resistance to apoptosis, hypersensitivity to hematopoietic cytokines, and the tendency to ..
  2. Inflammation and Immunosuppression in Lung Cancer
    Cong Yan; Fiscal Year: 2013
    ..A defect in myelopoiesis with increased myeloid progenitor cells was observed in the lal-/- bone marrow...
  3. Validation and Development of WEE1 as a therapeutic target in AML
    Christopher C Porter; Fiscal Year: 2013
    ..of Class I and II mutation expression and Wee1 inhibition as they relate to oncogenic stresses in myeloid progenitor cells and perform immunohistochemistry for Wee1 expression in AML bone marrow biopsy specimens...
  4. Myeloid Lineage Differentiation and Osteoclast Priming by a Novel Pax5 Cytokine
    Mark C Horowitz; Fiscal Year: 2013
    ..these cells secrete a cytokine(s) that induces proliferation and primes wild-type cells to also become myeloid progenitor cells. It is our hypothesis that the loss of Pax5 leads to the derepression of specific genes that allow the ..
  5. Dot 1 Complex, Transcriptional Elongation Control and Human Cancer
    Ali Shilatifard; Fiscal Year: 2013
    ..Direct fusion of Dot1 to MLL also results in the immortalization of myeloid progenitor cells and this immortalization activity depends on the H3K79 HMTase function of Dot1...
  6. Social threat primes myeloid progenitor cells and microglia: role in anxiety
    John F Sheridan; Fiscal Year: 2013
    ..associated with the egress and trafficking of bone marrow (BM)-derived, glucocorticoid (GC)-insensitive myeloid progenitor cells (MPCs)...
  7. Molecular Mechanisms of Myelokathexis
    Andrew Aprikyan; Fiscal Year: 2009
    ..We cloned the mutant gene products and expressed them in human myeloid progenitor cells. We propose to establish a model of myelokathexis based on tet- regulated expression of mutant CXCR4 in ..
  8. Genomic instability causes imatinib resistance in CML
    Tomasz Skorski; Fiscal Year: 2012
    ..and resistance to imatinib mesylate will be studied in CML hematopoietic stem cells (HSC), common myeloid progenitor cells (CMP), and granulocyte/macrophage progenitor cells (GMP) using anti-oxidant approaches and in vitro and ..
  9. The regulation of myeloid cell development and mobilization during autoimmune dem
    BENJAMIN MATTHEW SEGAL; Fiscal Year: 2013
    ..We have found that myeloid progenitor cells are mobilized from the bone marrow at an accelerated rate immediately prior to EAE exacerbations...
  10. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2013
    ..Several years ago, we indentified and characterized endothelial and myeloid progenitor cells as potential therapeutics useful for vascular- and neurotrophic rescue in the treatment of retinal ..
  11. Polyploidy, aneuploidy and genome stability
    DAVID S PELLMAN; Fiscal Year: 2013
    ..experiments will focus on the development of acute myelogenous leukemia because of methods to generate myeloid progenitor cells that do or do not contain polysomy 8...
  12. Identification and Characterization of Genes that Suppress BCR-ABL+ Leukemia
    Michael R Green; Fiscal Year: 2013
    ..is an oncogenic kinase derived from the translocation between chromosomes 9 and 22 that can transform myeloid progenitor cells and drives the development of the vast majority chronic myeloid leukemia (CML) cases and 20%-30% of adult ..
  13. Transplanted Stem Cells and Tumor Progression
    Melissa H Wong; Fiscal Year: 2010
    ..Based upon the observation that myeloid progenitor cells fuse with differentiated hepatocytes, we will identify the discrete subset of BMDCs that is competent to ..
  14. Stat3 Isoforms in Maturation and Survival of Normal and Malignant Myeloid Cells
    Michele S Redell; Fiscal Year: 2012
    ..intermediate for cytokine receptors that regulate the survival, proliferation, and differentiation of myeloid progenitor cells. StatS is aberrantly active in many different types of cancer, including acute myeloid leukemia (AML), ..
  15. Mechanisms of monocytosis and accelerated atherosclerosis in patients with CKD
    Anjali Ganda; Fiscal Year: 2013
    ..that their knockout leads to proliferation of hematopoietic stem and multipotential progenitor cells, myeloid progenitor cells, and increased blood monocytes in association with accelerated atherosclerosis...
  16. Regulation of Granulopoiesis by Fucosylation-Dependent Notch Signaling
    Lan Zhou; Fiscal Year: 2012
    ..deficient in cellular fucosylation, is consequent to loss of Notch-dependent signal transduction on myeloid progenitor cells. In this proposal, Dr...
  17. S100A8/A9 and carboxylated N-glycans in inflammation-mediated colon cancer
    GEETHA K SRIKRISHNA; Fiscal Year: 2010
    ..In this model we also found infiltrating S100A8/A9 positive myeloid progenitor cells in all regions of dysplasia and adenoma in colon...
  18. Altered monocyte function in relation to the CD33 Alzheimers disease locus
    Elizabeth M Bradshaw; Fiscal Year: 2013
    ..CD33 is one of these genes;the protein is a transmembrane glycoprotein expressed on the surface of myeloid progenitor cells and mature monocytes and appears to have a constitutive repressor function, subduing monocyte pro- ..
  19. PROMYELOCYTIC ZINC FINGER GENE
    Jennifer Morris; Fiscal Year: 1999
    ..The PLZF gene encodes a putative transcription factor that is expressed in myeloid progenitor cells and is down-regulated during in vitro differentiation...
  20. Mechanisms mediating HCMV genome maintenance during latency
    Laura Hertel; Fiscal Year: 2013
    ..cells to conclusively establish if and how maintenance of latent viral genomes is achieved in dividing myeloid progenitor cells. This work will provide significant insights into a crucial aspect of CMV latency, and will constitute ..
  21. MECHANISM UNDERLYING DCYVD MEDIATED PREFERENTIAL STIMULA
    Kapil Bhalla; Fiscal Year: 1993
    ..of this proposal is to evaluate the role of deoxycytidine (dCyd) as a growth protective agent for normal myeloid progenitor cells in antileukemic regimens consisting of dCyd analogs, or other pyrimidine antagonists, and high dose dCyd...
  22. Mechanisms mediating HCMV genome maintenance during latency
    Laura Hertel; Fiscal Year: 2012
    ..cells to conclusively establish if and how maintenance of latent viral genomes is achieved in dividing myeloid progenitor cells. This work will provide significant insights into a crucial aspect of CMV latency, and will constitute ..
  23. NR4A Nuclear Receptor Function in Leukemia
    Orla M Conneely; Fiscal Year: 2010
    ..tumor suppressor transcription factors operating most likely in hematopoietic stem (HSCs) or downstream myeloid progenitor cells and exert their effects by communication with cell cycle components to regulate the balance between serf ..
  24. PROGENITOR COLONY RT-PCR ANALYSIS IN CML TREATMENT
    Melanie Ehrlich; Fiscal Year: 2000
    ..RT-PCR assays to be done in this study will be those that use individual colonies derived in vitro from myeloid progenitor cells for analysis of the BCR/ABL product...
  25. Alcohol and Impairment of the Granulopoietic Response to Pneumonia
    Ping Zhang; Fiscal Year: 2010
    ..alcohol suppresses the granulopoietic response to pneumococcal pneumonia by impairing G-CSF signaling in myeloid progenitor cells. The proposed two specific aims are: 1) To test the hypothesis that alcohol inhibits the granulopoietic ..
  26. HEMATOTOXICITY OF PRENATAL CHLORDANE EXPOSURE
    John Barnett; Fiscal Year: 1999
    ..prenatal exposure to chlordane results in significant decreases in detectable hemopoietic stem cells, myeloid progenitor cells, and lymphoid precursors in the bone marrow of postnatal animals...
  27. ACTION OF RETINOIDS ON MYELOID LEUKEMIA
    H Koeffler; Fiscal Year: 1993
    ..potency of new retinoids on clonal growth and induction of differentiation of normal and neoplastic human myeloid progenitor cells in vitro...
  28. P-21 INDUCTION IN MYELOID DIFFERENTIATION
    Richard Steinman; Fiscal Year: 1999
    ..3. To determine whether forced expression of p21 enhances differentiation of murine and human myeloid progenitor cells; and to assess genetic and functional effects of forced expression of p21 in oncogene transformed myeloid ..
  29. NQO1 in Protection Against Benzene Toxicicity
    David Ross; Fiscal Year: 2007
    ..amounts of endothelial IL8 (elL8) which results in apoptosis of neighboring hematopoietic cells and myeloid progenitor cells resulting in aplastic anemia...
  30. CYTOKINE AND HORMONE INTERACTIONS IN COMORBIDITY OF AIDS
    Keith Kelley; Fiscal Year: 2005
    ..IGF-I targets both hematopoietic myeloid progenitor cells and muscle myoblasts, and here we hypothesize that the molecular mechanism for IGF-I receptor resistance ..
  31. DEREGULATION OF MYELOPOIESIS BY ZINC FINGER PROTEIN EVI1
    Archibald Perkins; Fiscal Year: 2004
    ..approach this by identifying and characterizing differences in transcription between Evi-1-expressing myeloid progenitor cells and control myeloid progenitor cells...
  32. MARROW REGULATION IN CYCLIC HEMATOPOIESIS
    David Dale; Fiscal Year: 2003
    ..to impaired cell survival and to determine the genes and proteins which mediate its regulatory effects on myeloid progenitor cells in this disease...
  33. BUTYRIC ACID DERIVATIVES IN MYELOID MALIGNANCIES
    Steven Gore; Fiscal Year: 1999
    ..with PB will be examined ex vivo to determine whether treatment with PB impacts on the sensitivity of myeloid progenitor cells to other differentiating agents, including growth factors and retinoids...
  34. MECHANISMS OF TRANSCRIPTIONAL REPRESSION BY AML1-ETO
    Bruce Hug; Fiscal Year: 2004
    ..Research will focus on transcriptional repression in myeloid progenitor cells. Recent work in Dr...
  35. Src Family Tyrosine Kinases in Tumor Cell Signaling
    THOMAS SMITHGALL; Fiscal Year: 2007
    ..Src family kinase inhibitors and dominant-negative mutants block Bcr- Abl-induced transformation of myeloid progenitor cells, strongly suggesting that Bcr-Abl cooperates with Src in CML pathogenesis...
  36. MOLECULAR REGULATION OF MYELIOD CELL DIFFERENTIATION
    Kathleen Sakamoto; Fiscal Year: 2000
    ..growth factors and their receptors play a critical role in lineage commitment and differentiation of myeloid progenitor cells. Egr-1, or early growth response gene-1 is an immediate early response gene which is required for ..
  37. Application of expanded progenitors against infections
    Holger Karsunky; Fiscal Year: 2005
    Our long term goal is to develop a cell-based therapy containing human myeloid progenitor cells to enhance resistance to pathogens and recovery from infections after hematopoietic cell transplantation or chemotherapy...
  38. CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMING
    Hal Broxmeyer; Fiscal Year: 2005
    ..These studies should clarity the relevance of SDF-1 and CXCR4 for homing/engraftment and mobilization of primary stem/progenitor cells. ..
  39. Molecular Studies of Severe Congenital Neutropenia
    Andrew Aprikyan; Fiscal Year: 2005
    ..than 90 percent of sporadic cases carry mutations in neutrophil elastase gene observed that bone marrow myeloid progenitor cells from SCN patients are characterized by a significantly accelerated rate of apoptosis and a transition ..
  40. Mitigation of Radiation-Induced GI Injury by Myeloid Progenitor Cells
    MARCY VANA; Fiscal Year: 2008
    ..Preliminary observations in the Brown lab have demonstrated the ability of myeloid progenitor cells (MP) to attenuate radiation-induced Gl injury in addition to the previously observed mitigation of ..
  41. Commitment mechanisms in hemato/lymphopoiesis
    Motonari Kondo; Fiscal Year: 2008
    ..The results obtained from this research proposal will allow us to better understand not only normal hematopoiesis but also aberrant hemato/lymphopoiesis that can result in leukemia or immunodeficiency. ..
  42. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2010
    ..The goal of this project is to elucidate the signaling pathways downstream of IL-7 receptor, which drive specific steps in lymphocyte development, and to determine the genes involved in this process. ..
  43. Regulation of osteoclastogenesis by TRANCE
    Yongwon Choi; Fiscal Year: 2004
    ....
  44. ROLE OF PBX AND PRE B ACUTE LYMPHOBLASTOID LEUKEMIA
    Cornelis Murre; Fiscal Year: 2004
    ..These studies should provide important information of how pbx molecules contribute to childhood leukemias and may suggest new avenues for the treatment of pre-B cell ALL. ..
  45. HU-UPCI Cancer Education/Career Development Partnership
    Richard Steinman; Fiscal Year: 2006
    ..abstract_text> ..
  46. Impact of Nutritional Status on Immune Function & Health
    Pamela Fraker; Fiscal Year: 2003
    ..abstract_text> ..
  47. REGULATION OF POLYMORPHONUCLEAR LEUKOCYTE PHAGOCYTOSIS
    Laurence Boxer; Fiscal Year: 2003
    ..Specific AIM 3 will examine the cellular targets of ceramide and sphingosine actin during PMN phagocytosis, focusing primarily on activation of mitogen-activated kinase (MAPK), Raf kinase and how they are linked to phagosome generation. ..
  48. REGULATION OF ACTIVATION INDUCED APOPTOSIS IN T CELLS
    Yongwon Choi; Fiscal Year: 2001
    ....
  49. Mast Cells in Physiology, Host Defese and Disease;
    STEPHEN GALLI; Fiscal Year: 2004
    ..Elucidating, at the molecular level, the positive and negative regulation of mast cell development and function; and 7. The development of definitive models for analyzing mast cell function in vivo. ..
  50. PROTO ONCOGENE PBX1 IN NORMAL HEMATOPOIETIC DEVELOPMENT
    Jorge DiMartino; Fiscal Year: 2005
    ..By defining the specific requirements for Pbx1 function in normal hematopoiesis, these experiments will further our understanding of the molecular pathogenesis of leukemia, aplastic anemia and myelodysplasia. ..
  51. Lineage decision in blood stem and progenitor cells
    Koichi Akashi; Fiscal Year: 2007
    ..Thus, we hope these studies will help understand mechanistic effects of these transcription factors on lineage decision in normal and malignant hematopoietic development. ..
  52. Activation of Bnip3 and Nix by Nutrient Deprivation
    James Thompson; Fiscal Year: 2007
    ..abstract_text> ..
  53. E PROTEIN AND B CELL DIFFERENTIATION
    Cornelis Murre; Fiscal Year: 2008
    ..Overall the dissection of the roles of E2A in B cell development should help to clarify the mechanism by how E-proteins regulate Blineage maturation. ..
  54. A cytokine that promotes dendritic cell survival
    Yongwon Choi; Fiscal Year: 2008
    ..These will, in turn, provide the basis for design of new immunotherapeutic strategies against tumors, viral diseases or autoimmune diseases that may arise from inadequate or inappropriate immune responses. ..
  55. Molecular Pathways to T-Lineage Commitment
    Cornelis Murre; Fiscal Year: 2009
    ..Overall the dissection of the roles of Notch signaling and transcriptional regulators should clarify the mechanisms by which T cell commitment is initiated and completed. ..
  56. Nuclear Receptor Co-Activators in the Lung
    Cong Yan; Fiscal Year: 2006
    ..abstract_text> ..
  57. TLS and TLS Fusion Proteins in Leukemia
    Liu Yang; Fiscal Year: 2005
    ..It is envisioned that successful completion of this project will unveil potential therapeutic targets in the treatment of human leukemias characterized by the t(16;21) translocation. ..
  58. REGULATION OF MAST CELL DEVELOPMENT AND FUNCTION
    STEPHEN JOSEPH GALLI; Fiscal Year: 2010
    ..abstract_text> ..
  59. NOVEL LG-LIKE RECEPTOR THAT REGULATES OSTEOCLASTOGENESIS
    Yongwon Choi; Fiscal Year: 2005
    ..abstract_text> ..
  60. Biomarkers of Formaldehyde Exposure and Toxicity
    Luoping Zhang; Fiscal Year: 2010
    ..and leukemia- specific chromosomal aberrations in peripheral blood lymphocytes (Aim 1) and circulating myeloid progenitor cells (Aim 2)...
  61. CHONDROGENESIS AND HISTONE MODIFICATION ENZYMES
    Liu Yang; Fiscal Year: 2007
    ....