smooth muscle myocytes

Summary

Summary: Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).

Top Publications

  1. ncbi Molecular regulation of vascular smooth muscle cell differentiation in development and disease
    Gary K Owens
    Dept of Molecular Physiology and Biological Physics, Univ of Virginia School of Medicine, 415 Lane Rd, Medical Research Building 5, Rm 1220, PO Box 801394, Charlottesville, VA 22908, USA
    Physiol Rev 84:767-801. 2004
  2. pmc Differential expression of microRNAs in myometrium and leiomyomas and regulation by ovarian steroids
    Qun Pan
    Department of Obstetrics and Gynecology, University of Florida, Gainesville, FL 32610, USA
    J Cell Mol Med 12:227-40. 2008
  3. ncbi Toll-like receptor 2, 3, and 4 expression and function in human airway smooth muscle
    Maria B Sukkar
    Experimental Studies Group, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Allergy Clin Immunol 118:641-8. 2006
  4. pmc Smooth muscle Notch1 mediates neointimal formation after vascular injury
    Yuxin Li
    Vascular Medicine Research, Brigham and Women s Hospital and Harvard Medical School, Cambridge, MA 02139, USA
    Circulation 119:2686-92. 2009
  5. ncbi PDGF and cardiovascular disease
    Elaine W Raines
    Department of Pathology, Harborview Medical Center, University of Washington, Box 359675, 325 9th Avenue, Seattle, WA 98104, USA
    Cytokine Growth Factor Rev 15:237-54. 2004
  6. ncbi TLR3-mediated synthesis and release of eotaxin-1/CCL11 from human bronchial smooth muscle cells stimulated with double-stranded RNA
    Kyoko Niimi
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    J Immunol 178:489-95. 2007
  7. ncbi Overexpression of heme oxygenase-1 protects smooth muscle cells against oxidative injury and inhibits cell proliferation
    Min Zhang
    Institute of Sports Medicine, The Third Hospital, Peking University, Beijing, China
    Cell Res 12:123-32. 2002
  8. pmc Depletion of membrane cholesterol eliminates the Ca2+-activated component of outward potassium current and decreases membrane capacitance in rat uterine myocytes
    A Shmygol
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV2 2DX, UK
    J Physiol 581:445-56. 2007
  9. ncbi Molecular determinants of vascular smooth muscle cell diversity
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville 22908, USA
    Circ Res 96:280-91. 2005
  10. ncbi Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide
    Pei Wang
    Department of Pharmacology, Second Military Medical University, 325 Guo He Road, Shanghai 200433, People s Republic of China
    Cardiovasc Res 81:370-80. 2009

Detail Information

Publications295 found, 100 shown here

  1. ncbi Molecular regulation of vascular smooth muscle cell differentiation in development and disease
    Gary K Owens
    Dept of Molecular Physiology and Biological Physics, Univ of Virginia School of Medicine, 415 Lane Rd, Medical Research Building 5, Rm 1220, PO Box 801394, Charlottesville, VA 22908, USA
    Physiol Rev 84:767-801. 2004
    ..The goal of this review is to summarize the current state of our knowledge in this area and to attempt to identify some of the key unresolved challenges and questions that require further study...
  2. pmc Differential expression of microRNAs in myometrium and leiomyomas and regulation by ovarian steroids
    Qun Pan
    Department of Obstetrics and Gynecology, University of Florida, Gainesville, FL 32610, USA
    J Cell Mol Med 12:227-40. 2008
    ....
  3. ncbi Toll-like receptor 2, 3, and 4 expression and function in human airway smooth muscle
    Maria B Sukkar
    Experimental Studies Group, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Allergy Clin Immunol 118:641-8. 2006
    ..Airway smooth muscle cells (ASMCs) display proinflammatory and immunomodulatory functions. ASMCs might participate in airway inflammatory responses associated with innate immune activation...
  4. pmc Smooth muscle Notch1 mediates neointimal formation after vascular injury
    Yuxin Li
    Vascular Medicine Research, Brigham and Women s Hospital and Harvard Medical School, Cambridge, MA 02139, USA
    Circulation 119:2686-92. 2009
    ..However, the pathophysiological role of Notch1 in the postnatal period is not known. We hypothesize that Notch1 signaling in vascular smooth muscle cells (SMCs) may contribute to neointimal formation after vascular injury...
  5. ncbi PDGF and cardiovascular disease
    Elaine W Raines
    Department of Pathology, Harborview Medical Center, University of Washington, Box 359675, 325 9th Avenue, Seattle, WA 98104, USA
    Cytokine Growth Factor Rev 15:237-54. 2004
    ..Other activities of PDGF identified in vivo suggest additional functions for PDGF in the pathogenesis of cardiovascular disease...
  6. ncbi TLR3-mediated synthesis and release of eotaxin-1/CCL11 from human bronchial smooth muscle cells stimulated with double-stranded RNA
    Kyoko Niimi
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    J Immunol 178:489-95. 2007
    ....
  7. ncbi Overexpression of heme oxygenase-1 protects smooth muscle cells against oxidative injury and inhibits cell proliferation
    Min Zhang
    Institute of Sports Medicine, The Third Hospital, Peking University, Beijing, China
    Cell Res 12:123-32. 2002
    ....
  8. pmc Depletion of membrane cholesterol eliminates the Ca2+-activated component of outward potassium current and decreases membrane capacitance in rat uterine myocytes
    A Shmygol
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV2 2DX, UK
    J Physiol 581:445-56. 2007
    ....
  9. ncbi Molecular determinants of vascular smooth muscle cell diversity
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville 22908, USA
    Circ Res 96:280-91. 2005
    ....
  10. ncbi Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide
    Pei Wang
    Department of Pharmacology, Second Military Medical University, 325 Guo He Road, Shanghai 200433, People s Republic of China
    Cardiovasc Res 81:370-80. 2009
    ..The present study was to determine whether visfatin is involved in these paracrine actions of PVAT, and if so, to explore the underlying mechanisms...
  11. ncbi C-reactive protein: risk marker or mediator in atherothrombosis?
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, 4635 Second Ave, Res 1 Bldg, Rm 3000, Sacramento, Calif 95817, USA
    Hypertension 44:6-11. 2004
    ..In conclusion, CRP is a risk marker for cardiovascular disease and, based on future studies, could emerge as a mediator in atherogenesis...
  12. ncbi Transforming growth factor-beta1 signaling contributes to development of smooth muscle cells from embryonic stem cells
    Sanjay Sinha
    Dept of Molecular Physiology and Biological Physics, Univ of Virginia, 415 Lane Rd, MR5, Rm 1220, PO Box 801394, Charlottesville, VA 22908, USA
    Am J Physiol Cell Physiol 287:C1560-8. 2004
    ..These results are the first to provide direct evidence that TGF-beta1 signaling through Smad2 and Smad3 plays an important role in the development of SMCs from totipotential ESCs...
  13. pmc NFATc3 mediates chronic hypoxia-induced pulmonary arterial remodeling with alpha-actin up-regulation
    Sergio de Frutos
    Department of Cell Biology and Physiology, School of Medicine, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Biol Chem 282:15081-9. 2007
    ..These results strongly suggest that NFATc3 plays a role in the chronic hypoxia-induced vascular changes that underlie pulmonary hypertension...
  14. pmc Multiple activation mechanisms of store-operated TRPC channels in smooth muscle cells
    A P Albert
    Ion Channel and Cell Signalling, Division of Basic Medical Sciences, St George s, University of London, Cranmer Terrace, London SW17 ORE, UK
    J Physiol 583:25-36. 2007
    ..We propose that the heterogeneity of the properties of these conductances in smooth muscle results from the formation of heterotetrameric TRPC structures in different smooth muscle preparations...
  15. pmc Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration
    Marie Potier
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    FASEB J 23:2425-37. 2009
    ..To our knowledge, these results are the first to show I(CRAC) in VSMCs and resolve a long-standing controversy by identifying CRAC as the elusive VSMC SOCE channel important for proliferation and migration...
  16. ncbi Calcium dynamics in cortical astrocytes and arterioles during neurovascular coupling
    Jessica A Filosa
    Department of Pharmacology, College of Medicine, University of Vermont, Burlington 05405 0068, USA
    Circ Res 95:e73-81. 2004
    ..The full text of this article is available online at http://circres.ahajournals.org...
  17. ncbi Human heat shock protein 60 stimulates vascular smooth muscle cell proliferation through Toll-like receptors 2 and 4
    Rick de Graaf
    Department of Radiology, Cardiovascular Research Institute Maastricht, University Hospital Maastricht, P Debyelaan 25, 6202 AZ, Maastricht, The Netherlands
    Microbes Infect 8:1859-65. 2006
    ..Moreover, our data surpass the infection- and autoimmunity-based hypotheses of cardiovascular disease and suggest an additional HSP60-related autocrine process...
  18. pmc Electrophysiological and functional effects of the KCNQ channel blocker XE991 on murine portal vein smooth muscle cells
    Shuk Yin M Yeung
    Department of Basic Medical Sciences, St George s University of London, Cranmer Terrace, London SW17 0RE
    Br J Pharmacol 146:585-95. 2005
    ..The stimulatory effect of XE991 was not affected by the presence of 4-AP, glibenclamide nor paxilline. These data provide evidence for an important role for KCNQ channels in governing cellular excitability in mPV smooth muscle cells...
  19. ncbi Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo
    Neil Cartwright
    Department of Critical Care, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Am J Respir Crit Care Med 175:595-603. 2007
    ..In animal models, gram-negative septic shock is mimicked by lipopolysaccharide (LPS), which signals through Toll-like receptor 4 (TLR4) and its adaptor MyD88. The role of NLRs in the pathophysiology of septic shock is not known...
  20. ncbi Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification
    Alessandra Moretti
    Massachusetts General Hospital Cardiovascular Research Center, Charles River Plaza CPZN 3208, 185 Cambridge Street, Boston, MA 02114, USA
    Cell 127:1151-65. 2006
    ....
  21. pmc A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells
    Jenna N Passman
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 105:9349-54. 2008
    ..We conclude that a restricted domain of Shh signaling is localized to the arterial adventitia and may play important roles in maintenance of resident vascular SMC progenitor cells in the artery wall...
  22. ncbi Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II
    Min Hee Choi
    Division of Molecular Life Sciences and the Center for Cell Signaling Research, Ewha Womans University, Seoul 120 750, Korea
    Nature 435:347-53. 2005
    ..These results demonstrate a localized role for endogenous H2O2 in PDGF signalling, and indicate a biological function of Prx II in cardiovascular disease...
  23. pmc Substrate compliance versus ligand density in cell on gel responses
    Adam Engler
    School of Engineering and Applied Science, Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Biophys J 86:617-28. 2004
    ..Based on such results, we hypothesize a central structural role for the cytoskeleton in driving the membrane outward during spreading whereas adhesion reinforces the spreading...
  24. ncbi Developmental basis of vascular smooth muscle diversity
    Mark W Majesky
    Department of Medicine, Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599 7126, USA
    Arterioscler Thromb Vasc Biol 27:1248-58. 2007
    ....
  25. pmc The contribution of inositol 1,4,5-trisphosphate and ryanodine receptors to agonist-induced Ca(2+) signaling of airway smooth muscle cells
    Yan Bai
    Dept of Physiology, Univ of Massachusetts Medical School, Worcester, 01655, USA
    Am J Physiol Lung Cell Mol Physiol 297:L347-61. 2009
    ....
  26. pmc Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation
    Jiyeon Oh
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 102:15122-7. 2005
    ..The phenotype of MRTF-B mutant mice is distinct from that of mice lacking myocardin, revealing unique roles for these serum response factor coactivators in the development of different subsets of smooth muscle cells in vivo...
  27. ncbi Vascular progenitor cells isolated from human embryonic stem cells give rise to endothelial and smooth muscle like cells and form vascular networks in vivo
    Lino S Ferreira
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Circ Res 101:286-94. 2007
    ....
  28. ncbi Selective gene silencing of either MMP-2 or MMP-9 inhibits invasion of human saphenous vein smooth muscle cells
    Neil A Turner
    Institute for Cardiovascular Research, School of Medicine, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
    Atherosclerosis 193:36-43. 2007
    ..Specific manipulation of either MMP-2 or MMP-9 may therefore provide a valuable strategy for prevention of SV graft stenosis in man...
  29. ncbi Modulation of the Ca2+ sensitivity of airway smooth muscle cells in murine lung slices
    Yan Bai
    Department of Physiology, University of Massachusetts Medical School, Worcester, 01655, USA
    Am J Physiol Lung Cell Mol Physiol 291:L208-21. 2006
    ....
  30. ncbi Antiproliferative effect of sildenafil on human pulmonary artery smooth muscle cells
    Benedetta Tantini
    Department of Biochemistry, G Moruzzi University of Bologna, Bologna, Italy
    Basic Res Cardiol 100:131-8. 2005
    ..We conclude that sildenafil exerts an antiproliferative effect on human PASMC that is mediated by an interaction between the cGMP-PKG and the cAMP-PKA activated pathways, leading to inhibition of PDGF-mediated activation of the ERK...
  31. pmc Conditional deletion of Krüppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, 415 Lane Rd, Charlottesville, VA 22908, USA
    Circ Res 102:1548-57. 2008
    ..Taken together, we have demonstrated that Klf4 plays a critical role in regulating expression of SMC differentiation markers and proliferation of SMCs in vivo in response to vascular injury...
  32. ncbi Stem cell-derived Sca-1+ progenitors differentiate into smooth muscle cells, which is mediated by collagen IV-integrin alpha1/beta1/alphav and PDGF receptor pathways
    Qingzhong Xiao
    Department of Cardiac and Vascular Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Am J Physiol Cell Physiol 292:C342-52. 2007
    ....
  33. ncbi A splicing repressor domain in polypyrimidine tract-binding protein
    Fiona Robinson
    Department of Biochemistry, University of Cambridge, UK
    J Biol Chem 281:800-6. 2006
    ..Our results highlight the fact that splicing repression by PTB can be uncoupled from the mode by which it binds to RNA...
  34. ncbi Phophatidylinositol-3 kinase/mammalian target of rapamycin/p70S6K regulates contractile protein accumulation in airway myocyte differentiation
    Andrew J Halayko
    Department of Medicine, University of Chicago, Illinois, USA
    Am J Respir Cell Mol Biol 31:266-75. 2004
    ....
  35. pmc Constitutively active L-type Ca2+ channels
    Manuel F Navedo
    Department of Physiology and Biophysics, University of Washington, Box 357290, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 102:11112-7. 2005
    ..We propose that Ca(2+) influx via persistent LTCCs may be an important mechanism regulating steady-state local and global Ca(2+) signals...
  36. ncbi Amphiregulin expression in human mast cells and its effect on the primary human lung fibroblasts
    Shen Wu Wang
    Tanox, Inc, Houston, TX 77025, USA
    J Allergy Clin Immunol 115:287-94. 2005
    ..Amphiregulin is a member of the epidermal growth factor family and has been shown to stimulate the proliferation of human keratinocytes in an autocrine manner...
  37. ncbi Synthetic responses in airway smooth muscle
    Peter H Howarth
    Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, United Kingdom
    J Allergy Clin Immunol 114:S32-50. 2004
    ..Combinations of long-acting beta(2)-agonists and corticosteroids appear to have additive and/or synergistic effects in inhibiting inflammatory mediator release and the migration and proliferation of ASM cells...
  38. ncbi Extracellular matrix proteins modulate asthmatic airway smooth muscle cell proliferation via an autocrine mechanism
    Peter R A Johnson
    Department of Pharmacology, University of Sydney, Sydney, NSW 2006, Australia
    J Allergy Clin Immunol 113:690-6. 2004
    ..We have previously shown that nonasthmatic ASM cells in culture produce a range of extracellular matrix protein proteins and that asthmatic ASM cells proliferate faster than cells from nonasthmatic patients...
  39. ncbi Resistin is secreted from macrophages in atheromas and promotes atherosclerosis
    Hye Seung Jung
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, South Korea
    Cardiovasc Res 69:76-85. 2006
    ..We examined if resistin was secreted from macrophages locally in atheromas and if it affected vascular cell function in human...
  40. ncbi Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells
    Jian Wang
    Division of Pulmonary and Critical Care Medicine, Institute for Cell Engineering, Baltimore, MD, USA
    Circ Res 98:1528-37. 2006
    ....
  41. pmc Interstitial flow induces MMP-1 expression and vascular SMC migration in collagen I gels via an ERK1/2-dependent and c-Jun-mediated mechanism
    Zhong Dong Shi
    City College of New York, City University of New York, Department of Biomedical Engineering, New York, NY 10031, USA
    Am J Physiol Heart Circ Physiol 298:H127-35. 2010
    ....
  42. ncbi The role of the human bladder lamina propria myofibroblast
    O J Wiseman
    Department of Uro Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    BJU Int 91:89-93. 2003
    ....
  43. pmc Universal physical responses to stretch in the living cell
    Xavier Trepat
    Program in Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 447:592-5. 2007
    ..These laws seem to be both universal and primitive, and thus comprise a striking intersection between the worlds of cell biology and soft matter physics...
  44. pmc Airway smooth muscle relaxation results from a reduction in the frequency of Ca2+ oscillations induced by a cAMP-mediated inhibition of the IP3 receptor
    Yan Bai
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Respir Res 7:34. 2006
    ..Therefore, we hypothesized that the relaxation of airway SMCs induced by agents that increase cAMP results from the down-regulation or slowing of the frequency of the Ca2+ oscillations...
  45. pmc Direct regulation of BK channels by phosphatidylinositol 4,5-bisphosphate as a novel signaling pathway
    Thirumalini Vaithianathan
    Department of Pharmacology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Gen Physiol 132:13-28. 2008
    ..These data indicate that endogenous PIP(2) directly activates vascular myocyte BK channels to control vascular tone...
  46. pmc Role of advanced glycation end products with oxidative stress in resistance artery dysfunction in type 2 diabetic mice
    Jun Su
    Department of Pharmacology, Tulane University, 1430 Tulane Ave, New Orleans LA 70112, USA
    Arterioscler Thromb Vasc Biol 28:1432-8. 2008
    ..Type 2 diabetes is associated with increased advanced glycation end product (AGE) formation and vasculopathy. We hypothesized that AGEs contribute to resistance artery dysfunction...
  47. pmc Desmin ensheathment ratio as an indicator of vessel stability: evidence in normal development and in retinopathy of prematurity
    Tailoi Chan-Ling
    Department of Anatomy, Institute for Biomedical Research, University of Sydney, Sydney, NSW 2006, Australia
    Am J Pathol 165:1301-13. 2004
    ..These observations lead us to suggest that a DER of 0.9 represents a vascular stability threshold and that a low DER observed during ROP raises the possibility that mural cell abnormalities play a key role in the pathogenesis of ROP...
  48. pmc An MT1-MMP-PDGF receptor-beta axis regulates mural cell investment of the microvasculature
    Kaisa Lehti
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 19:979-91. 2005
    ..Together, these data identify MT1-MMP as a novel proteolytic modifier of PDGF-B/PDGFRbeta signal transduction that cooperatively regulates vessel wall architecture in vivo...
  49. pmc Role of c-jun N-terminal kinase in the induced release of GM-CSF, RANTES and IL-8 from human airway smooth muscle cells
    Ute Oltmanns
    Thoracic Medicine, National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, UK
    Br J Pharmacol 139:1228-34. 2003
    ..5. JNK activation is involved in TNFalpha- and IL-1beta-induced GM-CSF, RANTES and IL-8 production from HASMC. JNK may therefore represent a critical pathway for cytokine production in HASMC...
  50. ncbi Ion channels in smooth muscle: regulators of intracellular calcium and contractility
    Kevin S Thorneloe
    Department of Pharmacology, College of Medicine, University of Vermont, Burlington 05405, USA
    Can J Physiol Pharmacol 83:215-42. 2005
    ..The expression pattern, density, and biophysical properties of ion channels vary among SM types and are key determinants of electrical activity, contractility, and SM function...
  51. ncbi IL-17R activation of human airway smooth muscle cells induces CXCL-8 production via a transcriptional-dependent mechanism
    M S Rahman
    Department of Immunology, University of Manitoba, BMSB, Faculty of Medicine, 730, William Avenue, Winnipeg, MB, Canada R3E0W3
    Clin Immunol 115:268-76. 2005
    ..Together, our findings suggest that ASM cells play an important role in airway neutrophilia...
  52. ncbi Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells
    Michael Roth
    Department of Pharmacology and the Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    N Engl J Med 351:560-74. 2004
    ..We examined the signaling pathway controlling the inhibitory effect of glucocorticoids on cell proliferation and interleukin-6 synthesis in bronchial smooth-muscle cells of subjects with asthma and those without asthma...
  53. ncbi IL-9-mediated induction of eotaxin1/CCL11 in human airway smooth muscle cells
    Abdelilah Soussi Gounni
    Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Immunol 173:2771-9. 2004
    ..Taken together, these data provide new evidence demonstrating that IL-9-dependent activation of ASM cells contributes to eosinophilic inflammation observed in asthma...
  54. ncbi Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of stromal cell-derived factor-1alpha
    Raphael A Nemenoff
    Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Denver, Denver, CO 80262, USA
    Circ Res 102:1036-45. 2008
    ....
  55. pmc A mathematical model of airway and pulmonary arteriole smooth muscle
    Inga Wang
    Department of Mathematics, University of Auckland, Auckland, New Zealand
    Biophys J 94:2053-64. 2008
    ..In addition, the model also predicts that oscillations in calcium concentration, commonly observed during agonist-induced smooth muscle contraction, cause a significantly greater contraction than an elevated steady calcium concentration...
  56. ncbi Altered S-phase kinase-associated protein-2 levels are a major mediator of cyclic nucleotide-induced inhibition of vascular smooth muscle cell proliferation
    Yih Jer Wu
    Bristol Heart Institute, University of Bristol, United Kingdom
    Circ Res 98:1141-50. 2006
    ..These data demonstrate for the first time that Skp2 is an important factor in VSMC proliferation and its inhibition by cyclic nucleotides...
  57. ncbi Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitro
    Yasuhiko Sakata
    Vascular Medicine Research, Brigham and Women s Hospital, Cambridge, Mass 02139, USA
    Arterioscler Thromb Vasc Biol 24:2069-74. 2004
    ..To determine the role of the cardiovascular-restricted, hairy-related bHLH transcription factor, CHF1/Hey2, in the biological response to vascular injury...
  58. ncbi Antiproliferative effects of phosphodiesterase type 5 inhibition in human pulmonary artery cells
    John Wharton
    Section on Experimental Medicine and Toxicology, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Am J Respir Crit Care Med 172:105-13. 2005
    ..Phosphodiesterase Type 5 (PDE5) inhibition represents a novel strategy for the treatment of pulmonary hypertension...
  59. pmc Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis
    Brigham C Willis
    Department of Anesthesiology Critical Care Medicine, Childrens Hospital Los Angeles, California, USA
    Am J Pathol 166:1321-32. 2005
    ..These results suggest that AECs undergo EMT when chronically exposed to TGF-beta1, raising the possibility that epithelial cells may serve as a novel source of myofibroblasts in IPF...
  60. pmc Functional up-regulation of KCNA gene family expression in murine mesenteric resistance artery smooth muscle
    S J Fountain
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK
    J Physiol 556:29-42. 2004
    ..The mechanism conferring up-regulated expression of KCNA genes may be common to all the gene family and play a functional role in the physiological control of blood pressure...
  61. ncbi Fraktalkine produced by airway smooth muscle cells contributes to mast cell recruitment in asthma
    Amr El-Shazly
    Universite Victor Segalen Bordeaux 2, Laboratoire de Physiologie Cellulaire Respiratoire, Institut National de la Sante et de la Recherche Medicale, E356, Bordeaux, France
    J Immunol 176:1860-8. 2006
    ....
  62. pmc NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-{beta}1 and insulin-like growth factor binding protein-3
    Saleh Ismail
    Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, University of Utah Health Sciences Centerand VA Medical Center, Salt Lake City, Utah 84132, USA
    Am J Physiol Lung Cell Mol Physiol 296:L489-99. 2009
    ..IGFBP-3 increases NOX4 gene expression, resulting in HPASMC proliferation. These observations add to our understanding hypoxic pulmonary vascular remodeling...
  63. ncbi K ATP channels of primary human coronary artery endothelial cells consist of a heteromultimeric complex of Kir6.1, Kir6.2, and SUR2B subunits
    Hidetada Yoshida
    Department of Pediatric Cardiology, New York University School of Medicine, 560 First Avenue TCH501, New York, NY 10016, USA
    J Mol Cell Cardiol 37:857-69. 2004
    ..We demonstrate that human coronary endothelial K(ATP) channels consist of a heteromultimeric complex of Kir6.1, Kir6.2, and SUR2B subunits...
  64. ncbi Allograft vasculopathy versus atherosclerosis
    Maziar Rahmani
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Providence Research Institute, Vancouver, British Columbia, Canada
    Circ Res 99:801-15. 2006
    ..The present review summarizes the current understanding of the risk factors and the pathophysiological similarities and differences between CAV and atherosclerosis...
  65. ncbi Roles of heme oxygenase-1 in curcumin-induced growth inhibition in rat smooth muscle cells
    Hyun Ock Pae
    Medicinal Resources Research Institute, Department of Microbiology and Immunology, Wonkwang University, Iksan 570 749, Korea
    Exp Mol Med 39:267-77. 2007
    ....
  66. ncbi TNF-alpha and calcium signaling in airway smooth muscle cells: a never-ending story with promising therapeutic relevance
    Yassine Amrani
    Am J Respir Cell Mol Biol 36:387-8. 2007
  67. ncbi Phenotype and functional plasticity of airway smooth muscle: role of caveolae and caveolins
    Andrew J Halayko
    Canada Research Chair in Airway Cell and Molecular Biology, Department of Physiology, Section of Respiratory Disease, Health Sciences Centre, University of Manitoba, Winnipeg, MB, R3A 1R8 Canada
    Proc Am Thorac Soc 5:80-8. 2008
    ..This review summarizes mechanisms regulating ASM cell phenotype plasticity, and the role of caveolae as determinants of the functional diversity of ASM cells of a particular phenotypic state...
  68. ncbi Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation
    Nathalie Auge
    INSERM U 466, Department of Biochemistry, CHU Rangueil, Toulouse, France
    Circulation 110:571-8. 2004
    ..MMPs are also able to induce SMC migration and proliferation in addition to extracellular matrix degradation. The present study was designed to investigate whether MMPs play a role in the mitogenic effect of oxLDLs...
  69. ncbi Effects of GnRH analogues, 'add-back' steroid therapy, antiestrogen and antiprogestins on leiomyoma and myometrial smooth muscle cell growth and transforming growth factor-beta expression
    N Chegini
    Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Mol Hum Reprod 8:1071-8. 2002
    ....
  70. pmc Reinforcement versus fluidization in cytoskeletal mechanoresponsiveness
    Ramaswamy Krishnan
    Program in Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 4:e5486. 2009
    ..Cytoskeletal softness and fragility, we argue, is consistent with early evolutionary adaptations of the eukaryotic cell to material properties of a soft inert microenvironment...
  71. ncbi Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells
    Anne Sturrock
    Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, University of Utah Health Sciences Center and Veterans Administration Medical Center, Salt Lake City, Utah 84132, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1543-55. 2007
    ....
  72. pmc Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis
    Tatsuo Hashimoto
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine and School of Medicine, Kanazawa Ku, Yokohama, Japan
    Am J Pathol 171:1705-12. 2007
    ..APJ deficiency is preventative against oxidative stress-linked atherosclerosis...
  73. ncbi Effects of fluid shear stress on adventitial fibroblast migration: implications for flow-mediated mechanisms of arterialization and intimal hyperplasia
    Jeffrey S Garanich
    Biomolecular Transport Dynamics Laboratory, Department of Bioengineering, The Pennsylvania State University, University Park, PA, USA
    Am J Physiol Heart Circ Physiol 292:H3128-35. 2007
    ..Because of the distinct migratory responses of SFBs and CFBs in response to SS, phenotype modulation appears to be one way to regulate their involvement in both physiological and pathological remodeling processes...
  74. ncbi Sustained orbital shear stress stimulates smooth muscle cell proliferation via the extracellular signal-regulated protein kinase 1/2 pathway
    Hidenori Asada
    Section of Vascular Surgery, Yale University School of Medicine, New Haven, Conn 06519, USA
    J Vasc Surg 42:772-80. 2005
    ....
  75. pmc CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation
    Saula Ravasi
    Laboratory of Molecular Pharmacology, Section of Eicosanoid Pharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Respir Res 7:42. 2006
    ..We used human ASMC (HASMC) to identify the signal transduction pathway(s) of the leukotriene D4 (LTD4)-induced DNA synthesis...
  76. ncbi Regulation of Toll-like receptor 4-induced proasthmatic changes in airway smooth muscle function by opposing actions of ERK1/2 and p38 MAPK signaling
    Xiaoyin Shan
    The Joseph Stokes Jr Research Institute, Division of Pulmonary Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Pennsylvania, USA
    Am J Physiol Lung Cell Mol Physiol 291:L324-33. 2006
    ....
  77. pmc Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin
    Joan Fitzgibbon
    National Centre for Biomedical and Engineering Science, National University of Ireland Galway, University Road, Galway, Ireland
    Reprod Biol Endocrinol 7:2. 2009
    ....
  78. ncbi Molecular basis of restenosis and novel issues of drug-eluting stents
    Teruo Inoue
    Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, Saga, Japan
    Circ J 73:615-21. 2009
    ..To improve long-term prognosis in the DES era, adjunctive medical treatments inducing early reendothelialization, but inhibiting SMC proliferation, would be required...
  79. ncbi TNF-alpha induced CD38 expression in human airway smooth muscle cells: role of MAP kinases and transcription factors NF-kappaB and AP-1
    K G Tirumurugaan
    Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, Minnesota 55108, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1385-95. 2007
    ..These results indicate that regulation of CD38 expression through p38 and JNK MAPKs involves NF-kappaB and AP-1 activation, and ERK and p38 MAPKs also regulate expression posttranscriptionally through message stability...
  80. ncbi Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses
    Gavin E Morris
    Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, Sheffield, S10 2JF, UK
    FASEB J 20:2153-5. 2006
    ..Thus, inflammatory responses to pathogens are regulated by networks in which patterns of TLR expression and colocalization of tissue cells and leukocytes are critical...
  81. pmc Interleukin-1beta promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways
    Jun Hee Lim
    Department of Immunology and Chronic Disease Research Center and Institute for Medical Science, School of Medicine, Keimyung University, Taegu 700 712, Korea
    Exp Mol Med 41:757-64. 2009
    ..These results suggest that IL-1beta induces MCP1 expression through activation of NF-kappaB via the PC-PLC/PKC signaling pathway...
  82. ncbi Mechanical stress-initiated signal transduction in vascular smooth muscle cells in vitro and in vivo
    Chaohong Li
    Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, Guangdong 510080, China
    Cell Signal 19:881-91. 2007
    ..The hypothesis could provide us some clues for exploring new therapeutic targets for the disturbed mechanical stress-initiated diseases such as hypertension and atherosclerosis...
  83. ncbi Modulation of calcium signaling by interleukin-13 in human airway smooth muscle: role of CD38/cyclic adenosine diphosphate ribose pathway
    Deepak A Deshpande
    Department of Veterinary Pathobiology, University of Minnesota, St Paul, MN, USA
    Am J Respir Cell Mol Biol 31:36-42. 2004
    ..These findings indicate that the CD38/cADPR-dependent pathway has a major role in IL-13-induced modulation of calcium signaling in human ASM...
  84. pmc An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension
    Georg Hansmann
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305 5162, USA
    J Clin Invest 118:1846-57. 2008
    ..Thus, PPARgamma-mediated events could protect against PAH, and PPARgamma agonists may reverse PAH in patients with or without BMP-RII dysfunction...
  85. ncbi Mechanical, biochemical, and extracellular matrix effects on vascular smooth muscle cell phenotype
    Jan P Stegemann
    Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Appl Physiol 98:2321-7. 2005
    ..Future improvements in creating more complex in vitro culture environments will lead to a better understanding of VSMC biology, new treatments for vascular disease, as well as improved blood vessel substitutes...
  86. ncbi TGF-beta potentiates airway smooth muscle responsiveness to bradykinin
    Jenny H Kim
    Pulmonary, Allergy, and Critical Care Division, Dept of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 289:L511-20. 2005
    ....
  87. ncbi Distribution of phenotypically disparate myocyte subpopulations in airway smooth muscle
    Andrew J Halayko
    Department of Physiology, Manitoba Institute of Child Health, University of Manitoba, Winnipeg, MB, Canada
    Can J Physiol Pharmacol 83:104-16. 2005
    ..The distinct roles of these subgroups could be a key determinant of normal and pathological lung development and biology...
  88. ncbi Probucol protects against smooth muscle cell proliferation by upregulating heme oxygenase-1
    Yi Mo Deng
    Centre for Vascular Research, University of New South Wales, and the Department of Haematology, Prince of Wales Hospital, Sydney Australia
    Circulation 110:1855-60. 2004
    ..Probucol is the only oral drug that inhibits restenosis in humans and intimal thickening in animals, although its underlying mechanism remains unclear...
  89. ncbi Ca(2+) spark sites in smooth muscle cells are numerous and differ in number of ryanodine receptors, large-conductance K(+) channels, and coupling ratio between them
    Ronghua Zhuge
    Department of Physiology, University of Massachusetts Medical Center, 55 Lake Ave North, Worcester, MA 01655, USA
    Am J Physiol Cell Physiol 287:C1577-88. 2004
    ..The implications of these findings for the organization of the spark microdomain are explored...
  90. ncbi Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells
    Rosalyn M Adam
    Urological Diseases Research Center, Department of Urology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
    Physiol Genomics 20:36-44. 2004
    ..Moreover, they suggest that mechanical and growth factor signals converge on common transcriptional regulators that include members of the AP-1 family...
  91. ncbi Mechanism for aldosterone potentiation of angiotensin II-stimulated rat arterial smooth muscle cell proliferation
    Fang Xiao
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Hypertension 44:340-5. 2004
    ..One way it may act is by modulating the expression and functions of the AT1 receptor...
  92. ncbi Altered airway responsiveness in CD38-deficient mice
    Deepak A Deshpande
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, Saint Paul, MN 55108, USA
    Am J Respir Cell Mol Biol 32:149-56. 2005
    ..The results of the present study demonstrate that CD38/cADPR contributes to airway smooth muscle tone and responsiveness through its effects on agonist-induced elevation of intracellular calcium in ASM cells...
  93. ncbi Smoothelin in vascular smooth muscle cells
    Guillaume J van Eys
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, University of Maastricht, 6200 MD Maastricht, The Netherlands
    Trends Cardiovasc Med 17:26-30. 2007
    ..Recently obtained data show that smoothelin deficiency results in a considerable loss of contractile potential and hence in impaired smooth muscle function and suggest that smoothelins are part of the contractile apparatus...
  94. ncbi Smooth muscle caveolae differentially regulate specific agonist induced bladder contractions
    V Cristofaro
    Division of Urology, VA Boston Healthcare System, Brigham and Women s Hospital, Boston, Massachusetts 02132, USA
    Neurourol Urodyn 26:71-80. 2007
    ..Therefore, the purpose of this study was to investigate the role of caveolae in the modulation of receptor-mediated signal transduction and determine the presence and localization of caveolin proteins in bladder tissue...
  95. ncbi Endothelin-induced contraction of bronchiole and pulmonary arteriole smooth muscle cells is regulated by intracellular Ca2+ oscillations and Ca2+ sensitization
    Jose F Perez-Zoghbi
    Dept of Physiology, Univ of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1000-11. 2007
    ..These results indicate that ET-induced contraction of bronchiole and arteriole SMCs is regulated by the frequency of Ca(2+) oscillations and by increasing the sensitivity of the contractile machinery to Ca(2+)...
  96. pmc Glucocorticoid- and protein kinase A-dependent transcriptome regulation in airway smooth muscle
    Anna M Misior
    Wake Forest University Health Sciences, Department of Internal Medicine and Center for Human Genomics, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Respir Cell Mol Biol 41:24-39. 2009
    ....
  97. ncbi Endogenous p53 protects vascular smooth muscle cells from apoptosis and reduces atherosclerosis in ApoE knockout mice
    John Mercer
    Division of Cardiovascular Medicine, University of Cambridge, PO Box 110, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Circ Res 96:667-74. 2005
    ..We conclude that endogenous levels of p53 protect VSMCs and stromal cells against apoptosis, while promoting apoptosis in macrophages, and protect against atherosclerosis development...
  98. ncbi cAMP phosphodiesterase inhibitors potentiate effects of prostacyclin analogs in hypoxic pulmonary vascular remodeling
    Peter G Phillips
    Section of Clinical Pharmacology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Am J Physiol Lung Cell Mol Physiol 288:L103-15. 2005
    ..Together, these findings provide a greater understanding of the role of cAMP PDEs in VSMC proliferation and provide rationale for combined use of prostacylcin analogs plus PDE3/4 inhibitors in treatment of pulmonary vascular remodeling...
  99. pmc Matrix metalloproteinase expression and activity in human airway smooth muscle cells
    Shona R Elshaw
    Division of Therapeutics and Molecular Medicine, University of Nottingham, University Hospital, Queens Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 142:1318-24. 2004
    ..Unstimulated cells secrete excess TIMP 1 and 2, preventing proteolytic activity. MMP-2 can be activated by thrombin which may contribute to airway remodelling...
  100. ncbi Endothelin-1 signalling in vascular smooth muscle: pathways controlling cellular functions associated with atherosclerosis
    Melanie E Ivey
    Cell Biology of Diabetes Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Atherosclerosis 199:237-47. 2008
    ....
  101. ncbi Overexpression of human Hsp27 inhibits serum-induced proliferation in airway smooth muscle myocytes and confers resistance to hydrogen peroxide cytotoxicity
    Sonemany Salinthone
    Department of Pharmacology, University of Nevada School of Medicine, Reno, Nevada, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1194-207. 2007
    ..The results support the notion that ASM cells can be stimulated to undergo proliferation and death and that Hsp27 may regulate these processes, thereby contributing to airway remodeling in asthmatics...

Research Grants67

  1. Sphingolipid modulators of vascular growth & homeostasis
    Timothy Hla; Fiscal Year: 2005
    ..These efforts will critically assess the central hypothesis that SKIEDG signaling system is a major regulator of angiogenesis. ..
  2. Regulation of Slo Splicing in the Urogenital Systme
    Kelvin Davies; Fiscal Year: 2006
    ..Our working hypothesis is that SIo isoform expression in smooth muscle myocytes is modulated by hormones, and moreover, that these changes in isoform expression are relevant to ..
  3. MOLECULAR ANALYSIS OF SIGNAL TRANSDUCTION IN THE HEART
    William Catterall; Fiscal Year: 2005
    ..In addition, the role of vascular smooth muscle myocytes will be studied using mice deficient in Type 3 adenylyl cyclase...
  4. K+ Channel Regulation/Cerebral Vascular Smooth Muscle
    LUIS SANTANA; Fiscal Year: 2007
    ..abstract_text> ..
  5. MOLECULAR MECHANISMS OF ARRHYTHMIAS DURING HEART FAILURE
    LUIS SANTANA; Fiscal Year: 2004
    ..The proposed work should provide fundamental information on the molecular mechanisms underlying arrhythmias during HF and could provide insights in the development of effective therapeutic strategies for this condition. ..
  6. Vascular Cell Regulation of Connexins
    Brant Isakson; Fiscal Year: 2005
    ..These results will be compared to similar experiments on in situ wild type and connexin KO animals. Combined, these methods will help delineate the physiological role of connexins between EC and SMC. ..
  7. Regulation of Vascular Calcification in Diabetes
    XUENING CHEN; Fiscal Year: 2007
    ....
  8. Smooth Muscle Ca Release in RYR and FKBP transgenic mice
    Michael Kotlikoff; Fiscal Year: 2006
    ..Moreover, the effect of this deletion on airway function will be determined, in order to assess the importance of this process in the complex control of airway tone. ..
  9. Fi02 and Blood Vessel Formation in Adult Lung
    Rosemary Jones; Fiscal Year: 2006
    ....
  10. Heterogeneity of hypoxic Ca2+ release in pulmonary and *
    Yong Xiao Wang; Fiscal Year: 2006
    ..The proposed studies are also of fundamental physiological significance with respect to the regulation of Ca2+ release in other cell types. ..
  11. Transgenic Mice- Recomb., Fate-Mapping,and Ca2+signaling
    Michael Kotlikoff; Fiscal Year: 2008
    ..We will use the mice to address important questions relating to neuromuscular transmission and the development and function of Interstitial Cells of Cajal (ICC) in the urogenital tract. ..
  12. Helical Rosette Nanotubes for Treating Osteoporotic Bone
    Thomas Webster; Fiscal Year: 2008
    ..abstract_text> ..
  13. Novel Signaling for Ca2+ and Release in Airway Myocytes
    Yong Xiao Wang; Fiscal Year: 2007
    ..6, and/or RyRs are ubiquitously expressed in a variety of cell types, the mechanistic findings from the proposed study will have general biological and pathological significance for various Ca2+-mediated cellular effects. ..
  14. RNA Aptamers to Green Fluorescent Protein for Cell Imaging
    Michael Kotlikoff; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  15. CALCIUM-INDUCED CALCIUM RELEASE & URINARY OBSTRUCTION
    Michael Kotlikoff; Fiscal Year: 2004
    ..abstract_text> ..
  16. Mechanisms for hypoxic Ca2+ release in pulmonary artery myocytes
    Yong Xiao Wang; Fiscal Year: 2010
    ..The findings from this proposal will enhance our understanding of cellular molecular mechanisms for hypoxic [Ca2+]i rise in PASMCs and associated HPV, and may lead to identify potential novel targets to treat pulmonary hypertension. ..
  17. Role of p70 S6 Kinase in Regulating LAM Cell Growth
    Vera P Krymskaya; Fiscal Year: 2010
    ....
  18. In Vivo Ca2+ and Voltage Imaging on The Urinary Bladder
    Michael I Kotlikoff; Fiscal Year: 2010
    ..These findings should provide a clearer understanding of smooth muscle dysfunction associated with urinary tract outflow obstruction. ..
  19. Design of Genetically Encoded Ca2+ Indicators for in Vivo Application
    Michael I Kotlikoff; Fiscal Year: 2010
    ..The proposal will produce novel proteins that will track the function of cells at the molecular level. ..
  20. PHYSIOLOGY AND PATHOLOGY OF SMOOTH MUSCLE HETEROGENEITY
    THOMAS EDDINGER; Fiscal Year: 2007
    ..4) SMC's found in the intimal thickening of an atherosclerotic vessel will differ in their myosin isoform expression and mechanical properties relative to the medial SMC's. [unreadable] [unreadable]..
  21. Glutathione Peroxidase & Redox State in Atherosclerosis
    Francis Miller; Fiscal Year: 2009
    ..Information gained from these studies will provide a foundation for additional studies of redox status in vascular disease and potential novel therapeutic strategies to modify the progression of atherosclerosis in patients. ..
  22. The regulation of airway ciliary activity
    Michael Sanderson; Fiscal Year: 2005
    ..abstract_text> ..
  23. Inhibition of leukocyte C2GlcNAcT--l reduces thrombosis
    Yuqing Huo; Fiscal Year: 2007
    ..Inhibition of C2GIcNAcT-I may be a novel approach for preventive and therapeutic interventions in arterial thrombosis in atherosclerosis. ..
  24. Development of Bioengineered Skeletal Muscle for Functional Replacement in vivo
    GEORGE JOSEPH CHRIST; Fiscal Year: 2010
    ..Tissue engineering of skeletal muscle in vitro for functional tissue replacement in vivo may provide a potential therapeutic solution to this unmet medical need. ..
  25. Is non-canonical Wnt signaling required in cardiac neural crest cells?
    Ethan David Cohen; Fiscal Year: 2008
    ..This.information may lead to new detection or treatment strategies. [unreadable] [unreadable] [unreadable]..
  26. Functional role of Angiopoietin-2 in diabetic heart
    Jian xiong Chen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  27. Influence of Innervation on Diaphragm Muscle Growth
    Gary Sieck; Fiscal Year: 2009
    ..In addition, factors that regulate the normal growth and development of the diaphragm will be systematically explored. ..
  28. Cardiac Stem Cell Growth, Aging and Death
    Jan Kajstura; Fiscal Year: 2008
    ..Conversely, inhibitors of the cell cycle and marker of cellular senescence increase in combination with oxidative DNA damage, potentiating the endogenous cell death pathway. ..
  29. Lysophosphatidic acid & tissue factor in atherosclerosis
    Mei Zhen Cui; Fiscal Year: 2007
    ..The proposed studies would also provide novel insight into the biological and cellular function of PKD and p90RSK in the vascular wall. ..
  30. INTERACTION OF ATHEROGENIC LIPOPROTEINS WITH MACROPHAGES
    IRA A TABAS; Fiscal Year: 2010
    ..abstract_text> ..
  31. Molecular mechanisms of airway smooth muscle function
    Dale Tang; Fiscal Year: 2007
    ..The knowledge obtained from these studies may disclose new biological targets for the development of more effective pharmacological treatment of pulmonary diseases such as asthma. ..
  32. Modulation of Cardiac E-C Coupling by Sorcin
    Hector Valdivia; Fiscal Year: 2008
    ..We will also determine the effects of overexpression and ablated expression of sorcin in ventricular cells. Finally, we will characterize a sorcin-null transgenic mouse. ..
  33. UNIT CONTROL OF MUSCLE BLOOD FLOW
    STEVEN SEGAL; Fiscal Year: 2007
    ..This insight will promote the development of novel strategies for the maintenance of an active lifestyle as well as rehabilitation and recovery from impaired physical work capacity. [unreadable] [unreadable]..
  34. Effects of intracellular angiotensin II
    Julia Cook; Fiscal Year: 2009
    ..abstract_text> ..
  35. GROWTH RELATED GENES IN VASCULAR SMOOTH MUSCLE
    MARK TAUBMAN; Fiscal Year: 2003
    ..These aims represent a comprehensive approach to establish the function of a novel gene family expressed in the cardiovasculature and to provide new insights into SMC gene regulation in vivo. ..
  36. Role of Adenosine Receptors in Mast Cells
    Igor Feoktistov; Fiscal Year: 2008
    ..Finally, in Specific Aim 4, we will explore the relevance of adenosine receptor subtypes in an in vivo model of chronic pulmonary inflammation. [unreadable] [unreadable]..
  37. Calcium signaling in airway smooth muscle in lung slices
    Michael Sanderson; Fiscal Year: 2007
    ..abstract_text> ..
  38. Effect of diflunisal (IND68092) on familial amyloidosis
    JOHN BERK; Fiscal Year: 2009
    ..poiuytrewq c Diflunisal drug levels will be determined to assess treatment compliance. We will correlate FAP disease progression with TTR stabilization. ..
  39. Analysis of Touch Response & Habituation in C. elegans
    William Schafer; Fiscal Year: 2007
    ..These studies will also provide a proving ground for improvements in optical imaging methodologies, which could facilitate the application of this cutting-edge technology to other genetically tractable organisms. ..
  40. Genetic analysis of C. elegans cellular ormoregulation
    Kevin Strange; Fiscal Year: 2004
    ..elegans will likely provide unique insights into osmoregulation, signaling mechanisms, and cellular stress and damage repair )rocesses in kidney cells as well as other mammalian cell types and tissues. ..
  41. FACTORS RESPONSIBLE FOR THE CONTROL OF HUMAN LABOR
    ROGER YOUNG; Fiscal Year: 2003
    ....
  42. Machine vision analysis of nematode behavioral patterns.
    William Schafer; Fiscal Year: 2003
    ..These analytical tools will also be used to precisely define the long-term effects of neuroactive drugs on behavioral, opening the possibility of genetic screening for mutants with defects in tolerance and dependence. ..
  43. CHLORIDE CHANNELS AND GASTRIC ACID SECRETION
    John Cuppoletti; Fiscal Year: 2003
    ..These studies strive to address the fundamental questions regarding the molecules and mechanisms involved in regulated HCl secretion. ..
  44. Microcirculation in Aging Skeletal Muscle
    STEVEN SEGAL; Fiscal Year: 2003
    ..Our long-term goal is to apply physiological genomics towards developing novel strategies for minimizing the adverse consequences of aging on muscle function and physical activity and to thereby preserve the quality of life. ..
  45. 2002 Symposium-Functional Genomics of Urogenital System
    George Christ; Fiscal Year: 2003
    ..Overall, we believe this conference will serve important scientific and educational ends and will stimulate new research in the basic understanding of urologic disorders in men and women. ..
  46. ALTERED MATRIX METALLOPROTEINASES IN HEART FAILURE
    JEANINE D ARMIENTO; Fiscal Year: 2002
    ..Finally, this proposal will investigate the role of interstitial collagenase (MMP-13) in cardiac function and development through the generation of an MMP-13 knockout mouse. ..
  47. IGFBP5 AND INTEGRINS AND CONTROLLING IGF1 ACTIONS
    David Clemmons; Fiscal Year: 2002
    ....
  48. NOS GENE TRANSFER IN PULMONARY HYPERTENSION
    David Rodman; Fiscal Year: 2002
    ....
  49. Derivation of Smooth Muscle Lineages from Stem Cells
    Gary Owens; Fiscal Year: 2004
    ....
  50. GENE THERAPY OF DIABETIC PENILE ENDOTHELIAL DYSFUNCTION
    Hunter Wessells; Fiscal Year: 2004
    ..Such a strategy may ultimately be beneficial to men with ED due to diabetes as well as smoking, hypercholesterolemia, and aging. ..
  51. INTERCELLULAR COORDINATION OF BLOOD FLOW CONTROL
    STEVEN SEGAL; Fiscal Year: 2004
    ....
  52. PLASTICITY IN DIAPHRAGM NEUROMOTOR CONTROL
    Gary Sieck; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  53. Native LDL, Cholesterol and Impaired Vasodilation
    Kirkwood Pritchard; Fiscal Year: 2006
    ..Investigations in to how 4F protects vascular function will provide new understanding of the mechanisms by which LDL impairs vasodilation and HDL protects vascular function. ..
  54. Mechanisms of uterine vascular adaptation in pregnancy
    Natalia Gokina; Fiscal Year: 2006
    ..abstract_text> ..
  55. GENETIC ANALYSIS OF NICOTINE ADAPTATION IN C ELEGANS
    William Schafer; Fiscal Year: 2006
    ..abstract_text> ..
  56. Mechanical Stretch and Vein Graft Intimal Hyperplasia
    Jeremy Goldman; Fiscal Year: 2005
    ..Specific Aim II: Investigate the role of platelet-derived growth factor (PDGF)-BB and related signaling molecules in mediating subsequent vascular cell proliferation. ..
  57. Plasticity N-Type Ca2+ Channels in Sympathetic Neurons
    ANN RITTENHOUSE; Fiscal Year: 2005
    ..This could help minimize cytotoxicity that can occur during cerebral vasospasm, stroke, epilepsy; and reduce mobility from cognitive, and/or learning and memory disorders. ..
  58. MICROVASCULAR INJURY DURING EXTRACORPOREAL LIFE SUPPORT
    Charles Cox; Fiscal Year: 2004
    ..Dr. McIntire's expertise in PMN/endothelial/blood flow interactions will provide an important addition to the candidate's training. ..
  59. INTEGRIN REGULATION BY R-RAS
    Erkki Ruoslahti; Fiscal Year: 2002
    ..As the R-ras interactions we have uncovered are novel for the Ras protein superfamily, new information on this important family of cellular regulators and oncoproteins will ensue. ..
  60. CALCIUM SIGNALING IN AIRWAY EPITHELIA AND SMOOTH MUSCLE
    Michael Sanderson; Fiscal Year: 2002
    ..With this understanding our ability to design therapies to counter obstructive lung disease and prevent asthmatic attacks will be enhanced. ..
  61. CHARACTERIZING MICROFIBRIL ABNORMALITIES IN SCLERODERMA
    Dianna Milewicz; Fiscal Year: 2003
    ..The research proposed in this grant will determine the contribution of abnormalities in fibrillin-1-containing microfibrils to the activation of fibroblasts, which leads to the fibrosis that characterizes SSc. ..
  62. MECHANISMS REGULATING AIRWAY MUSCLE GROWTH
    Reynold Panettieri; Fiscal Year: 2003
    ..These studies will define the mechanism by which agonists induce ASM cell growth such that new issues in the pathogenesis of asthma will be addressed and therapeutic measures to prevent these alterations can be developed. ..
  63. Mechanisms Regulation Functions of Airway Smooth Muscle
    Reynold Panettieri; Fiscal Year: 2007
    ..Thus, understanding the transcriptional mechanisms regulating the expression of inflammatory genes in ASM will likely lead to new therapeutic approaches for the treatment of asthma. ..
  64. DEVELOPMENTAL REGULATION OF O2 SENSING IN THE LUNG
    David Cornfield; Fiscal Year: 2009
    ..The strategy of modulating BKCa channel subunit expression to enhance pulmonary vasodilation may be more broadly applicable to other vascular diseases. ..
  65. ANTIMITOGENIC MECHANISMS OF PKG IN VASCULAR SM CELLS
    JESSE ROBERTS; Fiscal Year: 2004
    ..In addition, a carefully constructed training program has been developed that will permit successful development of an independent research career examining the basic mechanisms of pulmonary vascular diseases. ..