Genomes and Genes
Summary: Mature contractile cells, commonly known as myocytes, that form one of three kinds of muscle. The three types of muscle cells are skeletal (MUSCLE FIBERS), cardiac (MYOCYTES, CARDIAC), and smooth (MYOCYTES, SMOOTH MUSCLE). They are derived from embryonic (precursor) muscle cells called MYOBLASTS.
Publications264 found, 100 shown here
- Bone marrow stromal cells generate muscle cells and repair muscle degenerationMari Dezawa
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoecho, Sakyo ku, Kyoto, 606 8501 Japan
Science 309:314-7. 2005..These MSCs represent a more ready supply of myogenic cells than do the rare myogenic stem cells normally found in muscle and bone marrow...
- Wnt proteins regulate acetylcholine receptor clustering in muscle cellsBin Zhang
Department of Neurology and Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia 30912, USA
Mol Brain 5:7. 2012The neuromuscular junction (NMJ) is a cholinergic synapse that rapidly conveys signals from motoneurons to muscle cells and exhibits a high degree of subcellular specialization characteristic of chemical synapses...
- Interactions between neutrophils and macrophages promote macrophage killing of rat muscle cells in vitroHal X Nguyen
Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
J Physiol 547:125-32. 2003..In the present investigation, interactions between neutrophils, macrophages and muscle cells that may influence muscle cell death are examined...
- Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cellsCeline Aguer
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ontario, Canada
PLoS ONE 6:e28536. 2011....
- Connective tissue cells, but not muscle cells, are involved in establishing the proximo-distal outcome of limb regeneration in the axolotlEugen Nacu
Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307, Dresden, Germany
Development 140:513-8. 2013..Moreover, we show that, similarly to limb development, muscle patterning in regeneration is influenced by β-catenin signalling...
- Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cellsSandro M Hirabara
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Butanta, Sao Paulo, Brazil
J Cell Physiol 222:187-94. 2010..Primary cultures of rat skeletal muscle cells exhibited similar responses to saturated FFA as compared to C2C12 cells...
- Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cellsHenrike Sell
Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Dusseldorf, Germany
Diabetes 58:2731-40. 2009..This study was aimed at investigating the regulation of chemerin release and its effects on glucose metabolism in skeletal muscle cells.
- Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cellsYi Sun
Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
Proc Natl Acad Sci U S A 107:19909-14. 2010..Intriguingly, the AS160-targeted Rabs appear to differ, with Rab8A participating in GLUT4 exocytosis in muscle cells and Rab10 in adipocytes, and their activation by insulin is unknown...
- Systematic analysis of cis-elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cellsJerome E Lee
Program in Cell and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA
PLoS ONE 5:e11201. 2010..Moreover, just as transcription factor activity varies between different cell types, the factors influencing mRNA decay are also cell-type specific...
- Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C θ and εGirish Kewalramani
Cell Biology Program, The Hospital for Sick Children, Toronto, Canada
PLoS ONE 6:e26947. 2011..conditioned medium from macrophages treated with palmitate (CM-PA) reduces insulin action and glucose uptake in muscle cells. However, the mechanism whereby CM-PA confers this negative response onto muscle cells remains unknown.
- Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cellsNikolaos Dimopoulos
Division of Molecular Physiology, Centre for Interdisciplinary Research, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
Biochem J 399:473-81. 2006..of palmitoleate (a MUFA) and palmitate (a SFA) on insulin action and glucose utilization in rat L6 skeletal muscle cells. Basal glucose uptake was enhanced approx. 2-fold following treatment of cells with palmitoleate...
- Identification of S-nitrosylation motifs by site-specific mapping of the S-nitrosocysteine proteome in human vascular smooth muscle cellsTodd M Greco
Stokes Research Institute and Departments of Pediatrics and Pharmacology, Children s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 103:7420-5. 2006..capturing and site-specific adduct mapping to identify the targets of S-nitrosylation in human aortic smooth muscle cells upon exposure to S-nitrosocysteine and propylamine propylamine NONOate...
- Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathyLivia Casciola-Rosen
Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Exp Med 201:591-601. 2005..state, such that myositis autoantigen expression is increased in cells that have features of regenerating muscle cells. Consistent with this, we found that cultured myoblasts express high levels of autoantigens, which are ..
- High density lipoprotein (HDL) promotes glucose uptake in adipocytes and glycogen synthesis in muscle cellsQichun Zhang
Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing, People s Republic of China
PLoS ONE 6:e23556. 2011..This investigation was designed to determine the effects and mechanisms of HDL on glucose uptake in adipocytes and glycogen synthesis in muscle cells.
- Distinct roles for classical nuclear import receptors in the growth of multinucleated muscle cellsMonica N Hall
Graduate Program in Genetics and Molecular Biology, Emory University, Atlanta, GA 30322, USA
Dev Biol 357:248-58. 2011....
- Regulation of the intracellular localization of Foxo3a by stress-activated protein kinase signaling pathways in skeletal muscle cellsStephan Clavel
Université de Nice Sophia Antipolis EA 4319 INSERM ERI 21, 28 Avenue de Valombrose, 06108 Nice Cedex 2, France
Mol Cell Biol 30:470-80. 2010..This study aimed to identify signaling pathways involved in the control of Foxo3a nuclear translocation in muscle cells. We observed that after nuclear import of Foxo3a by PI3K/Akt pathway inhibition, activation of stress-activated ..
- Inflammatory response in human skeletal muscle cells: CXCL10 as a potential therapeutic targetClara Crescioli
Department of Health Sciences, University of Rome Foro Italico, 00135 Rome, Italy
Eur J Cell Biol 91:139-49. 2012..About 25% of patients are non-responders. Skeletal muscle cells seem actively involved in the immune-inflammatory response and not only a target; understanding the molecular ..
- TNF-alpha induces macroautophagy and regulates MHC class II expression in human skeletal muscle cellsChristian W Keller
Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York 10065, USA
J Biol Chem 286:3970-80. 2011....
- Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cellsS Famulla
Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Dusseldorf, Germany
Int J Obes (Lond) 35:762-72. 2011..The aim of this study was to investigate the regulation and autocrine function of PEDF in human adipocytes and to determine its paracrine effects on human skeletal muscle cells (hSkMC) and human smooth muscle cells (hSMC).
- Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cellsSimone Hettmer
The Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 108:20002-7. 2011....
- Bone and cartilage formation by skeletal muscle derived cellsM Mastrogiacomo
Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
J Cell Physiol 204:594-603. 2005..In this respect SMDCs resemble bone marrow stromal cells (BMSCs)...
- Angiotensin II-induced pro-fibrotic effects require p38MAPK activity and transforming growth factor beta 1 expression in skeletal muscle cellsMaria Gabriela Morales
Centro de Regulación Celular y Patología, Centro de Regeneración y Envejecimiento, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
Int J Biochem Cell Biol 44:1993-2002. 2012..These results strongly suggest that the fibrotic response to Ang-II is mediated by the AT-1 receptor and requires the p38MAPK phosphorylation, NOX-induced ROS, and TGF-β1 expression increase mediated by Ang-II in skeletal muscle cells.
- Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2Dennis Mathew
Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Science 310:1344-7. 2005..We conclude that, at synapses, Wingless signal transduction occurs through the nuclear localization of DFrizzled2-C for potential transcriptional regulation of synapse development...
- Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistanceIria Nieto-Vazquez
Department of Biochemistry, Faculty of Pharmacy, Universidad Complutense, 28040 Madrid, Spain
Diabetes 56:404-13. 2007..However, mice lacking PTP1B maintained a rapid clearance of glucose and insulin sensitivity and displayed normal muscle insulin signaling regardless the presence of TNF-alpha...
- Regulation of respiration in muscle cells in vivo by VDAC through interaction with the cytoskeleton and MtCK within Mitochondrial InteractosomeRita Guzun
Inserm U1055, Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, Grenoble, France
Biochim Biophys Acta 1818:1545-54. 2012..blot analysis we have shown that β2-tubulin coexpressed with mitochondria is highly important for cardiac muscle cells mitochondrial metabolism. Since it has been shown by Rostovtseva et al...
- Modelling cardiac fibroblasts: interactions with myocytes and their impact on impulse propagationVincent Jacquemet
Department of Biomedical Engineering, Duke University, 260 Hudson Hall, Box 90281, Durham, NC 27708, USA
Europace 9:vi29-37. 2007..This study aims at investigating in a biophysical model how much coupling would be necessary to perturb significantly the electrical propagation of the cardiac impulse...
- Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythmHiromitsu Negoro
Department of Urology, Graduate School of Medicine, Kyoto University, Sakyo, Kyoto 606 8507, Japan
Nat Commun 3:809. 2012..Bladder muscle cells have an internal clock, and show oscillations of connexin43 and gap junction function...
- Primary skeletal muscle cells trigger spontaneous Toxoplasma gondii tachyzoite-to-bradyzoite conversion at higher rates than fibroblastsMarialice da Fonseca Ferreira-da-Silva
Institute for Medical Microbiology, Georg August University, Kreuzbergring 57, 37075 Gottingen, Germany
Int J Med Microbiol 299:381-8. 2009..Here, we have followed the transition of tachyzoites to bradyzoites after infection of skeletal muscle cells (SkMC)...
- Not only insulin stimulates mitochondriogenesis in muscle cells, but mitochondria are also essential for insulin-mediated myogenesisPatrycja Pawlikowska
Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw Agricultural University, Nowoursynowska 159, 02 776 Warsaw, Poland
Cell Prolif 39:127-45. 2006Viability and myogenesis from C2C12 muscle cells and L6 rat myoblasts were dose-dependently stimulated by insulin...
- Preferential association of irreversibly silenced E2F-target genes with pericentromeric heterochromatin in differentiated muscle cellsValentina Guasconi
Institut Andre Lwoff, Centre National de la Recherche Scientifique CNRS, FRE2944, Universite Paris Sud, Villejuif, France
Epigenetics 5:704-9. 2010....
- Differential myocardial infarct repair with muscle stem cells compared to myoblastsHideki Oshima
Department of Orthopaedic Surgery, University of Pittsburgh, PA 15213 2582, USA
Mol Ther 12:1130-41. 2005..These findings indicate that MDSCs constitute an alternative to other myogenic cells for use in cardiac repair applications...
- AMP-activated protein kinase and the regulation of glucose transportNobuharu Fujii
Research Division, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
Am J Physiol Endocrinol Metab 291:E867-77. 2006..The identification of AMPK as a novel glucose transport mediator in skeletal muscle is providing important insights for the treatment and prevention of type 2 diabetes...
- Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocationShuhei Ishikura
Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada
Am J Physiol Cell Physiol 295:C1016-25. 2008..Moreover, there is controversy as to the AS160/TBC1D1 target Rabs in fat and muscle cells, and Rab effectors are unknown...
- FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C/EBP alphaA Mancini
Institut fuer Biochemie, Medizinische Hochschule Hannover, Hannover, Germany
Oncogene 26:1020-7. 2007..using the mesenchymal multipotent stem cells, C2C12 cells, that can differentiate into adipocytes, muscle cells and osteoblasts...
- Mesoangioblast stem cells ameliorate muscle function in dystrophic dogsMaurilio Sampaolesi
San Raffaele Scientific Institute, Universita Vita e Salute, Stem Cell Research Institute, Via Olgettina 58, 20132 Milan, Italy
Nature 444:574-9. 2006..The outcome is a remarkable clinical amelioration and preservation of active motility. These data qualify mesoangioblasts as candidates for future stem cell therapy for Duchenne patients...
- Comparative analysis of antisense oligonucleotide analogs for targeted DMD exon 46 skipping in muscle cellsA Aartsma-Rus
Center for Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg, AL Leiden, The Netherlands
Gene Ther 11:1391-8. 2004..Awaiting further improvements in oligochemistry, we thus consider 2OMePS AONs currently the most favorable compounds, at least for targeted DMD exon 46 skipping...
- Regulation of acetylcholine receptor clustering by ADF/cofilin-directed vesicular traffickingChi Wai Lee
Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, USA
Nat Neurosci 12:848-56. 2009..These results suggest that spatiotemporally restricted ADF/cofilin-mediated actin dynamics regulate AChR trafficking during the development of neuromuscular synapses...
- Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-beta1Zhihua Feng
Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, California 90089 2520, USA
J Neurosci 28:9599-609. 2008..Schwann cell-derived TGF-beta1 thus joins other astrocyte-derived synaptogenic factors in further strengthening the emerging concept that glial cells contribute to synaptogenesis in both the PNS and the CNS...
- Metabolic consequences of functional complexes of mitochondria, myofibrils and sarcoplasmic reticulum in muscle cellsT Andrienko
Laboratory of Fundamental and Applied Bioenergetics, INSERM E0221, Joseph Fourier University, Grenoble, France
J Exp Biol 206:2059-72. 2003..Inside these complexes, mitochondrial functional state is controlled by channeling of ADP, mostly via energy- and phosphoryl-transfer networks, and apparently depends on the state of sarcomere structures...
- Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signalingAnindita Das
Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0281, USA
J Biol Chem 280:12944-55. 2005..The results may have possible therapeutic potential in preventing myocyte cell death following ischemia/reperfusion...
- Purinergic activation of a leak potassium current in freshly dissociated myocytes from mouse thoracic aortaS Hayoz
Department of Zoology and Animal Biology, University of Geneva, Sciences III, Geneva, Switzerland
Acta Physiol (Oxf) 195:247-58. 2009..Exogenous ATP elicits a delayed calcium-independent K(+) current on freshly isolated mouse thoracic aorta myocytes. We investigated the receptor, the intracellular pathway and the nature of this current...
- Differentiation-induced radioresistance in muscle cellsLucia Latella
Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
Mol Cell Biol 24:6350-61. 2004....
- The LIM-only protein FHL2 regulates interleukin-6 expression through p38 MAPK mediated NF-κB pathway in muscle cellsChi Hang Wong
Department of Clinical Oncology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong Special Administrative Region, China
Cytokine 59:286-93. 2012..Other than classical immune tissues, IL-6 is also produced in muscle cells under specific conditions...
- Ginsenoside Rg1 promotes glucose uptake through activated AMPK pathway in insulin-resistant muscle cellsHye Min Lee
Graduate School of Biomedical Science, CHA University, Gyeonggi 463 836, Korea
Phytother Res 26:1017-22. 2012..on glucose uptake and the associated molecular mechanisms of the glucose transport system in insulin-resistant muscle cells. The insulin resistance of the muscle cell was induced by treatment of differentiated C2C12 cells with chronic ..
- Inflammatory gene expression by human colonic smooth muscle cellsSonemany Salinthone
Department of Pharmacology, University of Nevada School of Medicine, Reno, Nevada 89557 0270, USA
Am J Physiol Gastrointest Liver Physiol 287:G627-37. 2004..However, smooth muscle cells of the airway and vasculature also synthesize cytokines and chemokines...
- Opposing microtubule motors drive robust nuclear dynamics in developing muscle cellsMeredith H Wilson
Department of Physiology, Perelman School of Medicine at the University of Pennsylvania, D400 Richards Building, Philadelphia, PA 19104 6085, USA
J Cell Sci 125:4158-69. 2012..The three-dimensional rotation of myotube nuclei may facilitate their motility through the complex and crowded cellular environment of the developing muscle cell, allowing for proper myonuclear positioning...
- The UCS family of myosin chaperonesAlex H Hutagalung
Departments of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
J Cell Sci 115:3983-90. 2002..Although the mechanism of action of UCS proteins is unknown, recent biochemical studies suggest that they may act as molecular chaperones that facilitate the folding and/or maturation of myosin...
- Capsaicin stimulates glucose uptake in C2C12 muscle cells via the reactive oxygen species (ROS)/AMPK/p38 MAPK pathwaySoon Hee Kim
Nutrition and Metabolism Research Group, Korea Food Research Institute, Gyeonggi do 463 746, Republic of Korea
Biochem Biophys Res Commun 439:66-70. 2013..that capsaicin increases glucose uptake directly by activating AMP-activated protein kinase (AMPK) in C2C12 muscle cells, which manifested as an attenuation of glucose uptake when compound C, an AMPK inhibitor, was co-administered ..
- Function-based discovery of significant transcriptional temporal patterns in insulin stimulated muscle cellsBarbara Di Camillo
Information Engineering Department, University of Padova, Padova, Italy
PLoS ONE 7:e32391. 2012....
- Endoplasmic reticulum stress does not mediate palmitate-induced insulin resistance in mouse and human muscle cellsR Hage Hassan
INSERM, UMR S 872, Centre de Recherche des Cordeliers, Paris 75006, France
Diabetologia 55:204-14. 2012..Since it has been shown that ER stress can interfere with insulin signalling, our hypothesis was that the deleterious action of palmitate on the insulin signalling pathway in muscle cells could also involve ER stress.
- Skeletal muscle LIM protein 1 (SLIM1/FHL1) induces alpha 5 beta 1-integrin-dependent myocyte elongationMeagan J McGrath
Dept of Biochemistry and Molecular Biology, Monash Univ, Wellington Rd, Clayton, VIC 3800, Australia
Am J Physiol Cell Physiol 285:C1513-26. 2003..These results suggest that SLIM1 may play an important role during the early stages of skeletal muscle differentiation, specifically in alpha5beta1-integrin-mediated signaling pathways...
- Differential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile responseMargaret V Westfall
Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 280:41324-31. 2005....
- Short-term activation of peroxysome proliferator-activated receptor beta/delta increases fatty acid oxidation but does not restore insulin action in muscle cells from type 2 diabetic patientsCyrille Debard
INSERM U 449, INRA U 1235, R Laennec Faculty of Medicine, Human Nutrition Research Center, Claude Bernard Lyon 1 University, Rue G Paradin, 69372, Lyon, Cedex 08, France
J Mol Med (Berl) 84:747-52. 2006..of this study was to verify whether activation of fatty acid oxidation by PPARbeta agonists in human skeletal muscle cells prepared from type 2 diabetic patients could improve the reduced responses to insulin that characterized this ..
- Regulation of VEGF and bFGF mRNA expression and other proliferative compounds in skeletal muscle cellsL Jensen
Copenhagen Muscle Research Centre, Institute of Exercise and Sport Science, University of Copenhagen, Copenhagen, Denmark
Angiogenesis 7:255-67. 2004..effect of extracellular medium was determined in non-stimulated and electro-stimulated rat and human skeletal muscle cells. In rat skeletal muscle cells these aspects were also determined after treatment with inhibitors and/or donors ..
- NEU3 sialidase is activated under hypoxia and protects skeletal muscle cells from apoptosis through the activation of the epidermal growth factor receptor signaling pathway and the hypoxia-inducible factor (HIF)-1αRaffaella Scaringi
Department of Biomedical Sciences for Health, University of Milan, 20090 Segrate Milan, Italy
J Biol Chem 288:3153-62. 2013..sialidase, a key enzyme in ganglioside metabolism, is activated under hypoxic conditions in cultured skeletal muscle cells (C2C12)...
- Association between the muscle-specific proteins desmin and caveolin-3 in muscle cellsClaudia S Mermelstein
Departamento de Histologia e Embriologia, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Cell Tissue Res 327:343-51. 2007..We have thus shown, for the first time, an association between the intermediate filament protein desmin and caveolin-3 in myogenic cells...
- α-Catulin CTN-1 is required for BK channel subcellular localization in C. elegans body-wall muscle cellsBojun Chen
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA
EMBO J 29:3184-95. 2010..required for subcellular localization of SLO-1, the Caenorhabditis elegans BK channel α-subunit, in body-wall muscle cells. CTN-1 was identified in a genetic screen for mutants that suppressed a lethargic phenotype caused by ..
- Delineation of myotoxicity induced by 3-hydroxy-3-methylglutaryl CoA reductase inhibitors in human skeletal muscle cellsJulia Sacher
Center of Biomolecular Medicine and Pharmacology, Medical University of Vienna, Austria
J Pharmacol Exp Ther 314:1032-41. 2005..Here, we show that statins cause apoptosis in differentiated human skeletal muscle cells. The prototypical representative of statins, simvastatin, triggered sustained intracellular Ca(2+) transients, ..
- Effects of eicosapentaenoic acid and docosahexaenoic acid on uncoupling protein 3 gene expression in C(2)C(12) muscle cellsMak Soon Lee
Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120 750, Korea
Nutrients 5:1660-71. 2013..the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on UCP3 gene expression in C(2)C(12) muscle cells. EPA and DHA up-regulated UCP3 mRNA level in a dose-dependent manner and similarly increased UCP3 promoter ..
- Role of RalA downstream of Rac1 in insulin-dependent glucose uptake in muscle cellsShinsuke Nozaki
Division of Molecular Biology, Kobe University Graduate School of Medicine, Chuo Ku, Kobe, Japan
Cell Signal 24:2111-7. 2012..to examine the involvement of RalA in Rac1 regulation of the translocation of GLUT4 to the plasma membrane in muscle cells. Ectopic expression of a constitutively activated RalA mutant indeed stimulated GLUT4 translocation, suggesting ..
- Peroxisome proliferator-activated receptor-γ activation enhances insulin-stimulated glucose disposal by reducing ped/pea-15 gene expression in skeletal muscle cells: evidence for involvement of activator protein-1Paola Ungaro
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy
J Biol Chem 287:42951-61. 2012..Thus, ped/pea-15 is downstream of a major PPARγ-regulated inflammatory network. Repression of ped/pea-15 transcription might contribute to the PPARγ regulation of muscle sensitivity to insulin...
- Reprogramming of bone marrow mesenchymal stem cells into cardiomyocytesKeiichi Fukuda
Institute for Advanced Cardiac Therapeutics, Institute of Integrated Medical Research 7S1 7S2, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
C R Biol 325:1027-38. 2002..These findings indicated that cell transplantation therapy for the patients with heart failure might possibly be achieved using the regenerated cardiomyocytes from autologous bone marrow cells in the near future...
- Canonical TRP channels and mechanotransduction: from physiology to disease statesAmanda Patel
IPMC CNRS, Universite de Nice Sophia Antipolis, 660 route des Lucioles, 06560, Valbonne, France
Pflugers Arch 460:571-81. 2010..For instance, opening of the non-selective stretch-activated cation channels in smooth muscle cells is involved in the pressure-dependent myogenic constriction of resistance arteries...
- FATP4 contributes as an enzyme to the basal and insulin-mediated fatty acid uptake of C₂C₁₂ muscle cellsMargarete Digel
Molecular Cell Biology Laboratory Internal Medicine IV, University of Heidelberg, Heidelberg, Germany
Am J Physiol Endocrinol Metab 301:E785-96. 2011..Here, we investigated the function of FATP4 in basal and insulin mediated fatty acid uptake in C(2)C(12) muscle cells, a model system relevant for fatty acid metabolism...
- Genetic dissection of ion currents underlying all-or-none action potentials in C. elegans body-wall muscle cellsPing Liu
Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3401, USA
J Physiol 589:101-17. 2011..elegans body-wall myocytes generate all-or-none APs, which evoke Ca2+ release from the sarcoplasmic reticulum (SR), although the specific ion channels used for AP upstroke and repolarization differ...
- Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca(2+)-calmodulin-dependent protein kinase IIJerry Curran
Rush University, Chicago, IL, USA
J Mol Cell Cardiol 49:25-32. 2010..Treatment with ISO plus KN93 completely abolished this effect. The evidence suggests the ISO-dependent increase in SCaW activity in both healthy and failing myocytes is CaMKII-dependent, implicating CaMKII in arrhythmogenesis...
- Peroxisome proliferator-activated receptor-gamma coactivator-1alpha overexpression increases lipid oxidation in myocytes from extremely obese individualsLeslie A Consitt
Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina, USA
Diabetes 59:1407-15. 2010To determine whether the obesity-related decrement in fatty acid oxidation (FAO) in primary human skeletal muscle cells (HSkMC) is linked with lower mitochondrial content and whether this deficit could be corrected via overexpression of ..
- Nampt/visfatin/PBEF affects expression of myogenic regulatory factors and is regulated by interleukin-6 in chicken skeletal muscle cellsSusan M Krzysik-Walker
Department of Poultry Science, The Pennsylvania State University, University Park, PA 16802, USA
Comp Biochem Physiol A Mol Integr Physiol 159:413-21. 2011..mL(-1)) decreased Nampt mRNA abundance. Collectively, these results demonstrate that Nampt, regulated in part by IL-6, alters the expression of key myogenic transcription factors and thereby may influence postnatal myogenesis...
- USP19-deubiquitinating enzyme regulates levels of major myofibrillar proteins in L6 muscle cellsPriyanka Sundaram
Department of Medicine, Polypeptide Laboratory, McGill University and the McGill University Health Centre Research Institute, Montreal, Canada
Am J Physiol Endocrinol Metab 297:E1283-90. 2009..To further explore the role of USP19, we used small interfering RNA (siRNA) in L6 muscle cells. Lowering USP19 by 70-90% in myotubes resulted in a 20% decrease in the rate of proteolysis and an 18% decrease ..
- Regulation of the human oxytocin receptor by nuclear factor-kappaB and CCAAT/enhancer-binding protein-betaVasso Terzidou
Parturition Research Group, Institute of Reproductive and Developmental Biology, Hammersmith Hospital Campus, Du Cane Road, East Acton, London W12 ONN, United Kingdom
J Clin Endocrinol Metab 91:2317-26. 2006....
- High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitusBrian G Drew
Baker IDI Heart and Diabetes Institute, Melbourne, Australia
Circulation 119:2103-11. 2009..We hypothesized that HDL modulates glucose metabolism via elevation of plasma insulin and through activation of the key metabolic regulatory enzyme, AMP-activated protein kinase, in skeletal muscle...
- Protection of dystrophic muscle cells with polyphenols from green tea correlates with improved glutathione balance and increased expression of 67LR, a receptor for (-)-epigallocatechin gallateOlivier M Dorchies
Laboratory of Pharmacology, Geneva Lausanne School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland
Biofactors 35:279-94. 2009..Altogether our results demonstrate that GTP and EGCg protect muscle cells by scavenging H(2)O(2) and by improving the glutathione balance...
- Ear mesenchymal stem cells (EMSC) can differentiate into spontaneously contracting muscle cellsBarbara Gawronska-Kozak
Regenerative Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
J Cell Biochem 102:122-35. 2007..markers (CD44, CD73) and stem cell marker Sca-1 and can be differentiated into spontaneously contracting muscle cells. Treatment of cells with epidermal growth factor (EGF) change their morphology from fibroblast shapes into ..
- Downregulation of the Hsp90 system causes defects in muscle cells of Caenorhabditis elegansAndreas M Gaiser
Department of Chemistry and Center for Integrated Protein Science Munich CIPSM and Technische Universität München, Munchen, Germany
PLoS ONE 6:e25485. 2011..Furthermore, aggregates of the myosin MYO-3 are visible in muscle cells, if DAF-21 is depleted, implying a role of Hsp90 in the maintenance of muscle cell functionality...
- A method for the direct identification of differentiating muscle cells by a fluorescent mitochondrial dyeTetsuaki Miyake
Department of Physiology, University of Toronto, Best Institute Medical Research, Toronto, Canada
PLoS ONE 6:e28628. 2011Identification of differentiating muscle cells generally requires fixation, antibodies directed against muscle specific proteins, and lengthy staining processes or, alternatively, transfection of muscle specific reporter genes driving GFP ..
- [Lipopolysaccharide-mediated regulation of interleukin-6 in cultured human detrusor smooth muscle cells]J Neuhaus
Klinik und Poliklinik fur Urologie, Universitatsklinikum Leipzig AoR, Liebigstrasse 20, 04103 Leipzig
Urologe A 46:1193-7. 2007..The aim of the study is to define IL-6 target gene regulation in cultivated human detrusor smooth muscle cells.
- Apolipoprotein A-I stimulates AMP-activated protein kinase and improves glucose metabolismR Han
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, 200031, China
Diabetologia 50:1960-8. 2007..However, it is unknown whether APOA-I directly protects against diabetes. The aim of this study was to characterise the functional role of APOA-I in glucose homeostasis...
- Nuclei of non-muscle cells bind centrosome proteins upon fusion with differentiating myoblastsXavier Fant
Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
PLoS ONE 4:e8303. 2009..Concomitantly, proteins of the centrosome relocalize from the pericentriolar material to the outer surface of the nucleus. The mechanisms that govern this relocalization are largely unknown...
- Quantification of rapid Myosin regulatory light chain phosphorylation using high-throughput in-cell Western assays: comparison to Western immunoblotsHector N Aguilar
Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
PLoS ONE 5:e9965. 2010....
- Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cellsTim Ting Chiu
Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada
Mol Biol Cell 21:3529-39. 2010..We propose that Arp2/3 and cofilin coordinate a dynamic cycle of actin branching and severing at the cell cortex, essential for insulin-mediated GLUT4 translocation in muscle cells.
- Aldehyde dehydrogenase activity identifies a population of human skeletal muscle cells with high myogenic capacitiesKarine Vauchez
Inserm U974, Paris, France
Mol Ther 17:1948-58. 2009..Our results suggest that ALDH activity is a novel marker for a population of new human skeletal muscle progenitors presenting a potential for cell biology and cell therapy...
- Vitamin E protects the insulin sensitivity and redox balance in rat L6 muscle cells exposed to oxidative stressR Vinayaga Moorthi
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006, India
Clin Chim Acta 367:132-6. 2006The effect of reactive oxygen species (ROS) on insulin action is unclear. This study was carried out to explore the effect of prolonged low grade oxidative stress and vitamin E treatment on cultured rat L6 muscle cells.
- Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength trainingFrode Norheim
Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway
Am J Physiol Endocrinol Metab 301:E1013-21. 2011..Our aim was to identify the most abundantly secreted proteins in cultures of human skeletal muscle cells and to monitor their expression in muscles of strength-training individuals...
- The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic proteinValeria Kowaljow
Laboratorio de Neurogenética, Instituto de Investigacion, Médica Mercedes y Martín Ferreyra INIMEC CONICET, Cordoba, Argentina
Neuromuscul Disord 17:611-23. 2007..Overexpression of DUX4 induces cell death, induces caspase 3/7 activity and alters emerin distribution at the nuclear envelope. We propose that DUX4-mediated cell death contributes to the pathogenic pathway in FSHD...
- K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblastsL Chilton
Dept of Bioengineering, Univ of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
Am J Physiol Heart Circ Physiol 288:H2931-9. 2005..In combination, these results show that ventricular fibroblasts and myofibroblasts express a variety of K(+) channel alpha-subunits and demonstrate that Kir current can modulate RMP and alter essential physiological functions...
- AMP-activated protein kinase-regulated activation of the PGC-1alpha promoter in skeletal muscle cellsIsabella Irrcher
Department of Biology, York University, Toronto, Ontario, Canada
PLoS ONE 3:e3614. 2008..Our data identify a novel AMPK-mediated regulatory pathway that regulates PGC-1alpha gene expression. This could represent a potential therapeutic target to control PGC-1alpha expression in skeletal muscle...
- Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytesJeffrey G Jacot
Department of Bioengineering, University of California, San Diego, USA
Biophys J 95:3479-87. 2008..On very stiff substrates, this adaptation seems to involve RhoA kinase...
- Endotoxin and interferon-gamma inhibit translation in skeletal muscle cells by stimulating nitric oxide synthase activityRobert A Frost
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Shock 32:416-26. 2009..of the present study was to test the hypothesis that endogenous NO negatively affects translation in skeletal muscle cells after exposure to a combination of endotoxin (LPS) and interferon-gamma (IFN-gamma)...
- Degradation of sarcomeric and cytoskeletal proteins in cultured skeletal muscle cellsJuntipa Purintrapiban
Department of Animal Sciences, Oregon State University, Corvallis, OR 97331 6702, USA
Comp Biochem Physiol B Biochem Mol Biol 136:393-401. 2003..the proteasome and the lysosome in degradation of individual sarcomeric and cytoskeletal proteins in cultured muscle cells. Rat L8-CID muscle cells, in which we expressed a transgene calpain inhibitor (CID), were used in the study...
- Neuroligin-deficient mutants of C. elegans have sensory processing deficits and are hypersensitive to oxidative stress and mercury toxicityJerrod W Hunter
Genetic Models of Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Dis Model Mech 3:366-76. 2010..Our results suggest a possible link between genetic defects in synapse formation or function, and sensitivity to environmental factors in the development of autism spectrum disorders...
- Porcine peroxisome proliferator-activated receptor gamma induces transdifferentiation of myocytes into adipocytesY H Yu
Department of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan
J Anim Sci 84:2655-65. 2006..Therefore, the existence of serine 112 in PPARgamma may have a role in regulating adipocyte differentiation...
- Leptin expression in human primary skeletal muscle cells is reduced during differentiationRigmor Solberg
Department of Pharmacology, School of Pharmacy, University of Oslo, Oslo, Norway
J Cell Biochem 96:89-96. 2005..However, the expression of the leptin receptor (OB-Rb) mRNA, was unchanged during differentiation of the muscle cells. Administration of recombinant leptin had no effect on leptin, myogenin, myoD, or GLUT4 mRNA expressions during ..
- Growth hormone promotes skeletal muscle cell fusion independent of insulin-like growth factor 1 up-regulationAthanassia Sotiropoulos
Institut National de la Sante et de la Recherche Medicale, U810, and Faculté de Médecine Necker Enfants Malades, Universite Paris 5, F 75730 Paris, France
Proc Natl Acad Sci U S A 103:7315-20. 2006..Taken together, these data unravel a specific function of GH in the control of cell fusion, an essential process for muscle growth...
- Ceramide down-regulates System A amino acid transport and protein synthesis in rat skeletal muscle cellsRussell Hyde
Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee, UK
FASEB J 19:461-3. 2005..attenuate the basal and insulin-stimulated activity of the Na+-dependent System A amino acid transporter in rat muscle cells (L6 myotubes) by depletion of the plasma membrane abundance of SNAT2 (a System A isoform)...
- Rapid preparation of a plasma membrane fraction from adipocytes and muscle cells: application to detection of translocated glucose transporter 4 on the plasma membraneShin Nishiumi
Graduate School of Agricultural Science, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe, Hyogo 657 8501, Japan
Biosci Biotechnol Biochem 71:2343-6. 2007The aim of this study was to establish a rapid preparation of plasma membrane from adipocytes and muscle cells to detect translocated glucose transporter (GLUT) 4...
- Oxidative stress-associated mitochondrial dysfunction in corticosteroid-treated muscle cellsYasushi Oshima
Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
Muscle Nerve 30:49-54. 2004..Since these changes disappeared in the presence of SOD, dexamethasone primarily induced ROS generation, resulting in apoptosis. We speculate that this mechanism provides the basis of a pathophysiological model of corticosteroid myopathy...
- Rac1 signalling towards GLUT4/glucose uptake in skeletal muscleTim T Chiu
Program in Cell Biology, The Hospital for Sick Children, Toronto, Canada
Cell Signal 23:1546-54. 2011..actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle...
- Measuring phospholipase D activity in insulin-secreting pancreatic beta-cells and insulin-responsive muscle cells and adipocytesRosanna Cazzolli
Department of Medicine, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
Methods Mol Biol 462:241-51. 2009..cellular PLD activity in secretagogue-stimulated insulin-secreting pancreatic beta-cells and also insulin-stimulated adipocyte and muscle cells, two of the principal insulin-responsive cell types controlling blood glucose levels.
- Immortalized skin fibroblasts expressing conditional MyoD as a renewable and reliable source of converted human muscle cells to assess therapeutic strategies for muscular dystrophies: validation of an exon-skipping approach to restore dystrophin in DuchenSoraya Chaouch
Universite Pierre et Marie Curie Paris 06, UMRS 974, Paris F 75013, France
Hum Gene Ther 20:784-90. 2009..Cellular models seem straightforward to set up; however, the proliferative capacity of muscle cells isolated from dystrophic patients is limited, and in addition it is difficult to envisage the use of large ..
- Saffron (Crocus sativus L.) increases glucose uptake and insulin sensitivity in muscle cells via multipathway mechanismsChangkeun Kang
College of Veterinary Medicine, Gyeongsang National University, Jinju 660 701, South Korea
Food Chem 135:2350-8. 2012..saffron through investigating its signaling pathways associated with glucose metabolism in C(2)C(12) skeletal muscle cells. Saffron strongly enhanced glucose uptake and the phosphorylation of AMPK (AMP-activated protein kinase)/ACC (..
- Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandinsM Sussmann
Institut fur Pharmakologie und Klinische Pharmakologie, Heinrich Heine Universitat Dusseldorf, Germany
Circ Res 94:592-600. 2004..The regulation of HA synthesis by vasodilatory prostaglandins was analyzed in human arterial smooth muscle cells (SMCs)...
- MUSCLE CAPILLARY GEOMETRY, FLOW, AND OXYGEN TRANSFERDavid Poole; Fiscal Year: 2001....
- RECONSTITUTION OF CFTR CHLORIDE CHANNELJianjie Ma; Fiscal Year: 2004..Fulfillment of the experiments proposed in this project should provide further insights into the function and regulation of the CFTR Cl- channel, as well as the potential therapeutic interventiosn in cystic fibrosis. ..
- High fat feeding and intramyocellular lipid abnormalityZengKui Guo; Fiscal Year: 2005..Thus, the proposed research will improve the understanding of the mechanism of insulin resistance and imcTG abnormalities in the obese rat that will benefit investigation of human obesity. ..
- Role of MG29 in E-C Coupling of Striated MusclesJianjie Ma; Fiscal Year: 2006..long term goal of this project is to understand the cellular and molecular function of MG29 in E-C coupling of muscle cells, specifically to test the hypothesis that MG29 is a key protein involved in the biogenesis of the T-tubule ..
- Dynamics of Oxygen Uptake in Contracting Single MyocytesCASEY KINDIG; Fiscal Year: 2003..abstract_text> ..
- Store-Operated Calcium Entry and ApoptosisJianjie Ma; Fiscal Year: 2010..Knowledge on the molecular interactions between apoptosis mediators and cytosolic factors that control SOCE will enable us to establish therapeutic agents that target Ca signaling in cancer and degenerative diseases. ..
- SR Ca2+ ATPase, a determinant of cardiac contractilityMuthu Periasamy; Fiscal Year: 2007..As such, these studies are likely to suggest novel clinical strategies that might be pursued for the management of chronic heart failure in humans. [unreadable] [unreadable]..
- Targeting Antioxidant Therapy to Cardiac MitochondriaEVAN ABEL; Fiscal Year: 2006..Once efficacy is determined, promising reagents can then be subjected to pharmacokinetic and toxicological analysis following systemic administration. ..
- Uterine Vascular Adaptation to PregnancyLubo Zhang; Fiscal Year: 2005..Such an understanding has obvious clinical implications because the maladaptation of uterine circulation to pregnancy is associated with fetal developmental abnormalities and maternal cardiovascular disorders. ..
- MECHANISMS OF CELL INJURY IN BURN COMPLICATED BY SEPSISDeborah Carlson; Fiscal Year: 2006..The proposed work focuses on five specific aims to increase our understanding of the cellular events involved in burn and sepsis-related myocardial injury. ..
- Control of ATP Producing Pathways in Skeletal MuscleBrandon Walsh; Fiscal Year: 2005..determine the role of metabolic channeling in setting the onset kinetics of oxidative phosphorylation, and 3.) determine the intracellular PO2 at which respiration becomes O2 dependent. ..
- Beta3-Adrenergic Receptor & Progression to Heart FailureChe Ping Cheng; Fiscal Year: 2006..Thus, provide valuable new insight into the mechanism of the progression of functional impairment in CHF, and may assist in specifically targeting therapy for CHF. ..
- Cerebral artery Ca2+ signaling & subarachnoid hemorrhageGeorge Wellman; Fiscal Year: 2009..This study should significantly enhance current knowledge with respect to Ca2+signaling and constriction of cerebral arteries in health and disease and provide insight into possible new therapies for the treatment of cerebral vasospasm. ..
- Ion Channel Function in Arrhythmogenic Cardiac CellPENELOPE ALTMAN BOYDEN; Fiscal Year: 2010....
- Influence of Troponin I Phosphrylation by PKC on Contractile FunctionMargaret V Westfall; Fiscal Year: 2010..The ability to restore relaxation by gene transfer of Asp-substituted cTnl will be examined in failing myocytes. These studies could aid in the development of therapies to improve relaxation during heart failure. ..
- Redox Signaling in Osteoblast DifferentiationNandini Ghosh Choudhury; Fiscal Year: 2009..Understanding the signal transduction pathways of osteoblast differentiation may result in the development of therapeutic modalities for the human diseases where lack of bone formation is the pathology. ..
- Prenatal Cocaine Exposure and Cardiac ProgrammingLubo Zhang; Fiscal Year: 2009..abstract_text> ..
- SUMMER RESEARCH PROGRAM FOR MINORITY MEDICAL STUDENTSDonald Menick; Fiscal Year: 2008....
- Sex in MyocarditisSally Huber; Fiscal Year: 2008..By understanding the factors controlling virus infection and induction of innate immunity, better mechanism for controlling viral disease should be possible. ..
- Engineered neuronal networks for drug screeningPeter Molnar; Fiscal Year: 2008..abstract_text> ..
- K-Cl COTRANSPORTERS IN RAT NERVOUS SYSTEMJohn Payne; Fiscal Year: 2008....
- FASEB Summer Conference on: The Biology of Calpains in Health and DiseaseMelissa Spencer; Fiscal Year: 2007..The proposed program will provide the forum by which the momentum in this field may be maintained. [unreadable] [unreadable] [unreadable] [unreadable]..
- Cell Cycle Related Transdifferentation PlasticityMehrdad Abedi; Fiscal Year: 2007..This project will explore the functional plasticity of marrow to transdifferentate into nonhematopoietic tissues (heart, skeletal muscle and in liver). ..
- Lamin A Mutation and Hutchinson-Gilford ProgeriaHoward Worman; Fiscal Year: 2008..This project will establish how mutations in nuclear lamins A and C cause HGPS, and if inhibition of protein farnesylation is a potential therapeutic intervention. ..
- Ca2+ Waves and ArrhythmiasPENELOPE BOYDEN; Fiscal Year: 2008..abstract_text> ..
- INSECTICIDE ACTIONS ON GABA-A RECEPTORSGustav Akk; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- CAUSE AND CONSEQUENCE OF TNF OVEREXPRESSION IN THE HEARTDouglas Mann; Fiscal Year: 2007..Taken together, these studies will provide definitive new information with respect to the role of TGF-beta mediated Smad dependent signaling and myocardial fibrosis in an experimental model of sustained inflammation. ..
- Psychiatric Research Education Program(PREP)Carol Tamminga; Fiscal Year: 2007..Together, these features place the UTSWMC Department of Psychiatry in an ideal position to stimulate and train the next generation of basic and clinical psychiatric researchers. ..
- Functional assessment of donor-host cell couplingMICHAEL RUBART VAN DER LOHE; Fiscal Year: 2009..The studies proposed here will address fundamental hypotheses regarding the fate of donor cells following cellular transplantation into normal and injured hearts. ..
- Novel Methods for Cardiac Micro-Impedance MeasurementAndrew Pollard; Fiscal Year: 2005..abstract_text> ..
- CDI and Gamma Delta+ in Viral MyocarditisSally Huber; Fiscal Year: 2005..abstract_text> ..
- Adrenergic and Purinergic Regulation of Target CellsPaul A Insel; Fiscal Year: 2010....
- MECHANISM OF CHRONIC ALCOHOL INDUCED CARDIOMYOPATHYChe Ping Cheng; Fiscal Year: 2004..These studies are necessary to extend our knowledge about the mechanism in the development of ADCM and help target therapy for ADCM. ..
- IMPROVING SURVIVAL OF TRANSPLANTED DOPAMINE NEURONSKim Heidenreich; Fiscal Year: 2004....
- Arginase and Nitric Oxide in AtherosclerosisLouis Ignarro; Fiscal Year: 2004..The feasibility of this approach is borne out by the extensive preliminary data that support the central hypothesis. ..
- DIABETIC CARDIOMYOPATHY - ROLE OF INSULIN RESISTANCEAmy Davidoff; Fiscal Year: 2003..The development of cellular insulin resistance is likely to be a key factor in the etiology of diabetic cardiomyopathy and may represent the recapitulation of fetal gene expression, as shown for hypertrophic myocardium. ..
- ALCOHOL MODULATION OF CARDIAC CALCIUM CHANNELSGary Aistrup; Fiscal Year: 2003..This novel action may have major implications, given the widespread clinical use of dihydropyridines and other calcium channel antagonists. Drug interactions of this type will be an important focus of the project. ..
- Epithelial-stromal cell interactions in breast cancerKornelia Polyak; Fiscal Year: 2010....
- Cytoprotective cytokine signaling and reperfusion injuryDOUGLAS LOWELL MANN; Fiscal Year: 2010....
- ENDOGENOUS INHIBITOR OF NEURONAL INSP3-GATED CHANNELSJames Watras; Fiscal Year: 2002..regulation, and specificity of IRI as an endogenous inhibitor of neuronal InsP3 gated Ca channels, and thus may provide a foundation for studies aimed at abnormalities underlying altered intracellular Ca regulation in pathological states ..
- GENES THAT CONTROL CELL NUMBER--CARDIAC TNF & APOPTOSISDouglas Mann; Fiscal Year: 2002..Mechanisms and countermeasures for cardiac apoptosis will be tested by Dr. Doug Mann, with emphasis on dilated cardiomyopathy triggered by overexpression of tumor necrosis factor alpha, and on investigations of human myocardium. ..
- CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSISSally Huber; Fiscal Year: 2002..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
- Lamin A in Adipocyte Differentation and SurvivalHoward Worman; Fiscal Year: 2004..Confirmation of this hypothesis will have implications for the identification of new cellular targets to treat human obesity and diabetes mellitus. ..
- mAKAP-orchestrated phosphorylation events: regulation of PDE4D3Kimberly L Dodge Kafka; Fiscal Year: 2010..This study will further our understanding of the molecular mechanism of cardiac hypertrophy and help to identify novel targets for drug design to aid in the treatment of hypertrophy. ..
- Beta-Adrenergic Receptors of S49 Lymphoma CellsPaul Insel; Fiscal Year: 2005..Moreover, the results should prove applicable to the many other hormone and neurotransmitter receptors that link to G proteins. ..
- REG OF SM22 ALPHA TRANSCRIPTION IN SMOOTH MUSCLE CELLSMichael Parmacek; Fiscal Year: 2005DESCRIPTION (Applicant's abstract): The capacity of vascular smooth muscle cells (SMCs) to modulate their response to arterial injury has been implicated in the pathogenesis of vascular proliferative syndromes including atherosclerosis ..
- Role of Stretch to Endothelial Pulse-Perfusion ResponseDavid Kass; Fiscal Year: 2005..abstract_text> ..
- Molecular Basis of Myocardin Function in the HeartMichael S Parmacek; Fiscal Year: 2010..Myocardin is a remarkably potent transcriptional expressed exclusively in the heart and smooth muscle cells (SMCs)...
- DUX4 and Facioscapulohumeral Muscular DystrophyHoward Worman; Fiscal Year: 2004..The results obtained for DUX4 will be compared to DUX1, a non-pathological paralogue expressed in normal muscle cells. The results of this Exploratory/Developmental [R21] project will establish if abnormal expression of DUX4 ..
- Effect of defined surfaces on cardiac myocyte physiologyPeter Molnar; Fiscal Year: 2004..concerning the effect of the surface characteristics of engineered materials on the physiology of cardiac muscle cells. With the new surface modification methods the biomaterial / host interface could be determined/or studied/..
- Intramolecular Regulation of Ryanodine ReceptorsAlexander Shtifman; Fiscal Year: 2004..This work will provide novel information needed to better understand the process of EC coupling and also may shed new light on the nature of muscle disorders such as malignant hyperthermia. ..
- Signaling Pathways Mediating NCX1 ExpressionDonald Menick; Fiscal Year: 2004..The therapeutic modulation of these targets may potentially reverse the endpoints associated with the disease phenotype. ..
- GPCRs: Evolving Concepts and Drug DiscoveryPaul Insel; Fiscal Year: 2004..Attendees will thus have the chance to learn and discuss new cutting edge topics regarding GPCRs. ..
- Mechanisms of Myocardial Radiofrequency Scar ExpansionRupak Mukherjee; Fiscal Year: 2004..abstract_text> ..
- Sex in Viral MyocarditisSally Huber; Fiscal Year: 2004..These studies may provide new insights as to how viruses affect developing host defense responses and how hormones can modulate this initial response. ..
- INHIBITOR FORMATION IN GENE THERAPY FOR HEMOPHILIAKatherine High; Fiscal Year: 2001..These studies will involve a collaboration between the P.I.'s lab and the laboratory of Dr. Hildegund Ertl, an immunologist with experience in characterizing immune responses in the setting of viral vectors. ..
- SPECT MAMMOGRAPHY USING ROTATING SLANT HOLE COLLIMATORSTEPHEN KNISLEY; Fiscal Year: 2001..It will provide much improved capability in evaluating the extent and characterization of breast cancers for staging purposes that have been found useful in the surgical management of breast cancer. ..
- Actions of Ethanol on Ligand-Gated Ion ChannelsGustav Akk; Fiscal Year: 2006..The results from the experiments will be used to examine the mechanism and structural requirements in the ethanol-mediated modulation of the GABAA receptor function. ..
- Trypanosoma cruzi and AIDS: Role of the AdipocyteHerbert Tanowitz; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Cardiovascular Stiffening in Aged Patients with CHFDavid Kass; Fiscal Year: 2005..This could lead to new therapeutic approaches to this difficult clinical problem that affects a growing aged patient population. ..
- Novel epoxide hydrolase inhibitor for stroke preventionJOHN IMIG; Fiscal Year: 2005..In the Phase II work, Arete Therapeutics will use the collected information to progress toward clinical trials in the area of stroke and possible new therapeutic avenues. ..
- Diastolic Function in Hypertrophic CardiomyopathyCarolyn Ho; Fiscal Year: 2003..Such genotype-phenotype correlations have the potential to improve our ability to risk stratify and monitor patients, and may ultimately inspire noel approaches to management. ..
- HYPERTENSION: CONTRIBUTION OF ARTERIAL WALL CHANGESRobert Cox; Fiscal Year: 2007Voltage-gated K+ (Kv) currents in native vascular smooth muscle cells (VSMC) are inhibited by an increase in cytosolic free Ca2+, secondary to intracellular Ca 2+ release or extracellular Ca2+ influx...
- ROLES FOR P38 MAP KINASES IN CARDIAC MYOCYTE GROWTHCHRISTOPHER GLEMBOTSKI; Fiscal Year: 2003..abstract_text> ..
- The ER Stress Response and ATF6 Activation in the HeartCHRISTOPHER GLEMBOTSKI; Fiscal Year: 2007..The ERSR has gone virtually unstudied in the heart; accordingly, the proposed studies are novel and will enhance our understanding of the ERSR and the roles played by ATF6 alpha and beta in the stressed myocardium. ..
- Impact of feeding on brain response to food stimuli in lean and obese subjectsMarie Pierre St Onge; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATIONSANDRA HASLAM; Fiscal Year: 2007..The long-term goal of this proposal is the delineation of the mechanisms of P-dependent growth regulation in the adult normal mammary gland that may lead to novel strategies for the prevention and treatment of breast cancer. ..
- Examination of the Limbic Cortex in SchizophreniaCarol Tamminga; Fiscal Year: 2006..These data will have implications for understanding the mechanisms of the illness and for directing future new drug discovery for schizophrenia therapeutics. ..
- Comparitive Antipsychotic Drug Actions on Brain NeurochemistryCarol Tamminga; Fiscal Year: 2007..Concentration on mouse behaviors, neurochemistry and behavior will advance studies aimed at kinetic applications. ..
- TRYPANOSOMA CRUZI: PATHOGENESIS OF INFECTIONHerbert Tanowitz; Fiscal Year: 2005..cruzi activates the NF-KappaB pathway in endothelial and vascular smooth muscle cells by investigating the role of the generation of reactive oxygen species and cytoplasmic phospholipase A2 ..