muscle cells


Summary: Mature contractile cells, commonly known as myocytes, that form one of three kinds of muscle. The three types of muscle cells are skeletal (MUSCLE FIBERS), cardiac (MYOCYTES, CARDIAC), and smooth (MYOCYTES, SMOOTH MUSCLE). They are derived from embryonic (precursor) muscle cells called MYOBLASTS.

Top Publications

  1. ncbi Bone marrow stromal cells generate muscle cells and repair muscle degeneration
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoecho, Sakyo ku, Kyoto, 606 8501 Japan
    Science 309:314-7. 2005
  2. pmc Wnt proteins regulate acetylcholine receptor clustering in muscle cells
    Bin Zhang
    Department of Neurology and Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Mol Brain 5:7. 2012
  3. pmc Interactions between neutrophils and macrophages promote macrophage killing of rat muscle cells in vitro
    Hal X Nguyen
    Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
    J Physiol 547:125-32. 2003
  4. pmc Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells
    Celine Aguer
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ontario, Canada
    PLoS ONE 6:e28536. 2011
  5. ncbi Connective tissue cells, but not muscle cells, are involved in establishing the proximo-distal outcome of limb regeneration in the axolotl
    Eugen Nacu
    Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307, Dresden, Germany
    Development 140:513-8. 2013
  6. ncbi Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells
    Sandro M Hirabara
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Butanta, Sao Paulo, Brazil
    J Cell Physiol 222:187-94. 2010
  7. pmc Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells
    Henrike Sell
    Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Dusseldorf, Germany
    Diabetes 58:2731-40. 2009
  8. pmc Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells
    Yi Sun
    Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
    Proc Natl Acad Sci U S A 107:19909-14. 2010
  9. pmc Systematic analysis of cis-elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cells
    Jerome E Lee
    Program in Cell and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA
    PLoS ONE 5:e11201. 2010
  10. pmc Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C θ and ε
    Girish Kewalramani
    Cell Biology Program, The Hospital for Sick Children, Toronto, Canada
    PLoS ONE 6:e26947. 2011

Detail Information

Publications264 found, 100 shown here

  1. ncbi Bone marrow stromal cells generate muscle cells and repair muscle degeneration
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoecho, Sakyo ku, Kyoto, 606 8501 Japan
    Science 309:314-7. 2005
    ..These MSCs represent a more ready supply of myogenic cells than do the rare myogenic stem cells normally found in muscle and bone marrow...
  2. pmc Wnt proteins regulate acetylcholine receptor clustering in muscle cells
    Bin Zhang
    Department of Neurology and Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Mol Brain 5:7. 2012
    The neuromuscular junction (NMJ) is a cholinergic synapse that rapidly conveys signals from motoneurons to muscle cells and exhibits a high degree of subcellular specialization characteristic of chemical synapses...
  3. pmc Interactions between neutrophils and macrophages promote macrophage killing of rat muscle cells in vitro
    Hal X Nguyen
    Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
    J Physiol 547:125-32. 2003
    ..In the present investigation, interactions between neutrophils, macrophages and muscle cells that may influence muscle cell death are examined...
  4. pmc Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells
    Celine Aguer
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ontario, Canada
    PLoS ONE 6:e28536. 2011
  5. ncbi Connective tissue cells, but not muscle cells, are involved in establishing the proximo-distal outcome of limb regeneration in the axolotl
    Eugen Nacu
    Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307, Dresden, Germany
    Development 140:513-8. 2013
    ..Moreover, we show that, similarly to limb development, muscle patterning in regeneration is influenced by β-catenin signalling...
  6. ncbi Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells
    Sandro M Hirabara
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Butanta, Sao Paulo, Brazil
    J Cell Physiol 222:187-94. 2010
    ..Primary cultures of rat skeletal muscle cells exhibited similar responses to saturated FFA as compared to C2C12 cells...
  7. pmc Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells
    Henrike Sell
    Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Dusseldorf, Germany
    Diabetes 58:2731-40. 2009
    ..This study was aimed at investigating the regulation of chemerin release and its effects on glucose metabolism in skeletal muscle cells.
  8. pmc Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells
    Yi Sun
    Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
    Proc Natl Acad Sci U S A 107:19909-14. 2010
    ..Intriguingly, the AS160-targeted Rabs appear to differ, with Rab8A participating in GLUT4 exocytosis in muscle cells and Rab10 in adipocytes, and their activation by insulin is unknown...
  9. pmc Systematic analysis of cis-elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cells
    Jerome E Lee
    Program in Cell and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA
    PLoS ONE 5:e11201. 2010
    ..Moreover, just as transcription factor activity varies between different cell types, the factors influencing mRNA decay are also cell-type specific...
  10. pmc Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C θ and ε
    Girish Kewalramani
    Cell Biology Program, The Hospital for Sick Children, Toronto, Canada
    PLoS ONE 6:e26947. 2011
    ..conditioned medium from macrophages treated with palmitate (CM-PA) reduces insulin action and glucose uptake in muscle cells. However, the mechanism whereby CM-PA confers this negative response onto muscle cells remains unknown.
  11. pmc Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells
    Nikolaos Dimopoulos
    Division of Molecular Physiology, Centre for Interdisciplinary Research, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 399:473-81. 2006
    ..of palmitoleate (a MUFA) and palmitate (a SFA) on insulin action and glucose utilization in rat L6 skeletal muscle cells. Basal glucose uptake was enhanced approx. 2-fold following treatment of cells with palmitoleate...
  12. pmc Identification of S-nitrosylation motifs by site-specific mapping of the S-nitrosocysteine proteome in human vascular smooth muscle cells
    Todd M Greco
    Stokes Research Institute and Departments of Pediatrics and Pharmacology, Children s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 103:7420-5. 2006
    ..capturing and site-specific adduct mapping to identify the targets of S-nitrosylation in human aortic smooth muscle cells upon exposure to S-nitrosocysteine and propylamine propylamine NONOate...
  13. pmc Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy
    Livia Casciola-Rosen
    Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Exp Med 201:591-601. 2005
    ..state, such that myositis autoantigen expression is increased in cells that have features of regenerating muscle cells. Consistent with this, we found that cultured myoblasts express high levels of autoantigens, which are ..
  14. pmc High density lipoprotein (HDL) promotes glucose uptake in adipocytes and glycogen synthesis in muscle cells
    Qichun Zhang
    Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing, People s Republic of China
    PLoS ONE 6:e23556. 2011
    ..This investigation was designed to determine the effects and mechanisms of HDL on glucose uptake in adipocytes and glycogen synthesis in muscle cells.
  15. pmc Distinct roles for classical nuclear import receptors in the growth of multinucleated muscle cells
    Monica N Hall
    Graduate Program in Genetics and Molecular Biology, Emory University, Atlanta, GA 30322, USA
    Dev Biol 357:248-58. 2011
  16. pmc Regulation of the intracellular localization of Foxo3a by stress-activated protein kinase signaling pathways in skeletal muscle cells
    Stephan Clavel
    Université de Nice Sophia Antipolis EA 4319 INSERM ERI 21, 28 Avenue de Valombrose, 06108 Nice Cedex 2, France
    Mol Cell Biol 30:470-80. 2010
    ..This study aimed to identify signaling pathways involved in the control of Foxo3a nuclear translocation in muscle cells. We observed that after nuclear import of Foxo3a by PI3K/Akt pathway inhibition, activation of stress-activated ..
  17. ncbi Inflammatory response in human skeletal muscle cells: CXCL10 as a potential therapeutic target
    Clara Crescioli
    Department of Health Sciences, University of Rome Foro Italico, 00135 Rome, Italy
    Eur J Cell Biol 91:139-49. 2012
    ..About 25% of patients are non-responders. Skeletal muscle cells seem actively involved in the immune-inflammatory response and not only a target; understanding the molecular ..
  18. pmc TNF-alpha induces macroautophagy and regulates MHC class II expression in human skeletal muscle cells
    Christian W Keller
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York 10065, USA
    J Biol Chem 286:3970-80. 2011
  19. ncbi Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells
    S Famulla
    Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Dusseldorf, Germany
    Int J Obes (Lond) 35:762-72. 2011
    ..The aim of this study was to investigate the regulation and autocrine function of PEDF in human adipocytes and to determine its paracrine effects on human skeletal muscle cells (hSkMC) and human smooth muscle cells (hSMC).
  20. pmc Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells
    Simone Hettmer
    The Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 108:20002-7. 2011
  21. ncbi Bone and cartilage formation by skeletal muscle derived cells
    M Mastrogiacomo
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    J Cell Physiol 204:594-603. 2005
    ..In this respect SMDCs resemble bone marrow stromal cells (BMSCs)...
  22. ncbi Angiotensin II-induced pro-fibrotic effects require p38MAPK activity and transforming growth factor beta 1 expression in skeletal muscle cells
    Maria Gabriela Morales
    Centro de Regulación Celular y Patología, Centro de Regeneración y Envejecimiento, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Int J Biochem Cell Biol 44:1993-2002. 2012
    ..These results strongly suggest that the fibrotic response to Ang-II is mediated by the AT-1 receptor and requires the p38MAPK phosphorylation, NOX-induced ROS, and TGF-β1 expression increase mediated by Ang-II in skeletal muscle cells.
  23. pmc Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2
    Dennis Mathew
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 310:1344-7. 2005
    ..We conclude that, at synapses, Wingless signal transduction occurs through the nuclear localization of DFrizzled2-C for potential transcriptional regulation of synapse development...
  24. ncbi Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance
    Iria Nieto-Vazquez
    Department of Biochemistry, Faculty of Pharmacy, Universidad Complutense, 28040 Madrid, Spain
    Diabetes 56:404-13. 2007
    ..However, mice lacking PTP1B maintained a rapid clearance of glucose and insulin sensitivity and displayed normal muscle insulin signaling regardless the presence of TNF-alpha...
  25. ncbi Regulation of respiration in muscle cells in vivo by VDAC through interaction with the cytoskeleton and MtCK within Mitochondrial Interactosome
    Rita Guzun
    Inserm U1055, Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, Grenoble, France
    Biochim Biophys Acta 1818:1545-54. 2012
    ..blot analysis we have shown that β2-tubulin coexpressed with mitochondria is highly important for cardiac muscle cells mitochondrial metabolism. Since it has been shown by Rostovtseva et al...
  26. pmc Modelling cardiac fibroblasts: interactions with myocytes and their impact on impulse propagation
    Vincent Jacquemet
    Department of Biomedical Engineering, Duke University, 260 Hudson Hall, Box 90281, Durham, NC 27708, USA
    Europace 9:vi29-37. 2007
    ..This study aims at investigating in a biophysical model how much coupling would be necessary to perturb significantly the electrical propagation of the cardiac impulse...
  27. pmc Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm
    Hiromitsu Negoro
    Department of Urology, Graduate School of Medicine, Kyoto University, Sakyo, Kyoto 606 8507, Japan
    Nat Commun 3:809. 2012
    ..Bladder muscle cells have an internal clock, and show oscillations of connexin43 and gap junction function...
  28. ncbi Primary skeletal muscle cells trigger spontaneous Toxoplasma gondii tachyzoite-to-bradyzoite conversion at higher rates than fibroblasts
    Marialice da Fonseca Ferreira-da-Silva
    Institute for Medical Microbiology, Georg August University, Kreuzbergring 57, 37075 Gottingen, Germany
    Int J Med Microbiol 299:381-8. 2009
    ..Here, we have followed the transition of tachyzoites to bradyzoites after infection of skeletal muscle cells (SkMC)...
  29. ncbi Not only insulin stimulates mitochondriogenesis in muscle cells, but mitochondria are also essential for insulin-mediated myogenesis
    Patrycja Pawlikowska
    Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw Agricultural University, Nowoursynowska 159, 02 776 Warsaw, Poland
    Cell Prolif 39:127-45. 2006
    Viability and myogenesis from C2C12 muscle cells and L6 rat myoblasts were dose-dependently stimulated by insulin...
  30. ncbi Preferential association of irreversibly silenced E2F-target genes with pericentromeric heterochromatin in differentiated muscle cells
    Valentina Guasconi
    Institut Andre Lwoff, Centre National de la Recherche Scientifique CNRS, FRE2944, Universite Paris Sud, Villejuif, France
    Epigenetics 5:704-9. 2010
  31. ncbi Differential myocardial infarct repair with muscle stem cells compared to myoblasts
    Hideki Oshima
    Department of Orthopaedic Surgery, University of Pittsburgh, PA 15213 2582, USA
    Mol Ther 12:1130-41. 2005
    ..These findings indicate that MDSCs constitute an alternative to other myogenic cells for use in cardiac repair applications...
  32. ncbi AMP-activated protein kinase and the regulation of glucose transport
    Nobuharu Fujii
    Research Division, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Physiol Endocrinol Metab 291:E867-77. 2006
    ..The identification of AMPK as a novel glucose transport mediator in skeletal muscle is providing important insights for the treatment and prevention of type 2 diabetes...
  33. ncbi Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation
    Shuhei Ishikura
    Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada
    Am J Physiol Cell Physiol 295:C1016-25. 2008
    ..Moreover, there is controversy as to the AS160/TBC1D1 target Rabs in fat and muscle cells, and Rab effectors are unknown...
  34. ncbi FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C/EBP alpha
    A Mancini
    Institut fuer Biochemie, Medizinische Hochschule Hannover, Hannover, Germany
    Oncogene 26:1020-7. 2007
    ..using the mesenchymal multipotent stem cells, C2C12 cells, that can differentiate into adipocytes, muscle cells and osteoblasts...
  35. ncbi Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs
    Maurilio Sampaolesi
    San Raffaele Scientific Institute, Universita Vita e Salute, Stem Cell Research Institute, Via Olgettina 58, 20132 Milan, Italy
    Nature 444:574-9. 2006
    ..The outcome is a remarkable clinical amelioration and preservation of active motility. These data qualify mesoangioblasts as candidates for future stem cell therapy for Duchenne patients...
  36. ncbi Comparative analysis of antisense oligonucleotide analogs for targeted DMD exon 46 skipping in muscle cells
    A Aartsma-Rus
    Center for Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg, AL Leiden, The Netherlands
    Gene Ther 11:1391-8. 2004
    ..Awaiting further improvements in oligochemistry, we thus consider 2OMePS AONs currently the most favorable compounds, at least for targeted DMD exon 46 skipping...
  37. pmc Regulation of acetylcholine receptor clustering by ADF/cofilin-directed vesicular trafficking
    Chi Wai Lee
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, USA
    Nat Neurosci 12:848-56. 2009
    ..These results suggest that spatiotemporally restricted ADF/cofilin-mediated actin dynamics regulate AChR trafficking during the development of neuromuscular synapses...
  38. pmc Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-beta1
    Zhihua Feng
    Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, California 90089 2520, USA
    J Neurosci 28:9599-609. 2008
    ..Schwann cell-derived TGF-beta1 thus joins other astrocyte-derived synaptogenic factors in further strengthening the emerging concept that glial cells contribute to synaptogenesis in both the PNS and the CNS...
  39. ncbi Metabolic consequences of functional complexes of mitochondria, myofibrils and sarcoplasmic reticulum in muscle cells
    T Andrienko
    Laboratory of Fundamental and Applied Bioenergetics, INSERM E0221, Joseph Fourier University, Grenoble, France
    J Exp Biol 206:2059-72. 2003
    ..Inside these complexes, mitochondrial functional state is controlled by channeling of ADP, mostly via energy- and phosphoryl-transfer networks, and apparently depends on the state of sarcomere structures...
  40. ncbi Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling
    Anindita Das
    Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0281, USA
    J Biol Chem 280:12944-55. 2005
    ..The results may have possible therapeutic potential in preventing myocyte cell death following ischemia/reperfusion...
  41. ncbi Purinergic activation of a leak potassium current in freshly dissociated myocytes from mouse thoracic aorta
    S Hayoz
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Geneva, Switzerland
    Acta Physiol (Oxf) 195:247-58. 2009
    ..Exogenous ATP elicits a delayed calcium-independent K(+) current on freshly isolated mouse thoracic aorta myocytes. We investigated the receptor, the intracellular pathway and the nature of this current...
  42. pmc Differentiation-induced radioresistance in muscle cells
    Lucia Latella
    Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Mol Cell Biol 24:6350-61. 2004
  43. ncbi The LIM-only protein FHL2 regulates interleukin-6 expression through p38 MAPK mediated NF-κB pathway in muscle cells
    Chi Hang Wong
    Department of Clinical Oncology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong Special Administrative Region, China
    Cytokine 59:286-93. 2012
    ..Other than classical immune tissues, IL-6 is also produced in muscle cells under specific conditions...
  44. ncbi Ginsenoside Rg1 promotes glucose uptake through activated AMPK pathway in insulin-resistant muscle cells
    Hye Min Lee
    Graduate School of Biomedical Science, CHA University, Gyeonggi 463 836, Korea
    Phytother Res 26:1017-22. 2012
    ..on glucose uptake and the associated molecular mechanisms of the glucose transport system in insulin-resistant muscle cells. The insulin resistance of the muscle cell was induced by treatment of differentiated C2C12 cells with chronic ..
  45. ncbi Inflammatory gene expression by human colonic smooth muscle cells
    Sonemany Salinthone
    Department of Pharmacology, University of Nevada School of Medicine, Reno, Nevada 89557 0270, USA
    Am J Physiol Gastrointest Liver Physiol 287:G627-37. 2004
    ..However, smooth muscle cells of the airway and vasculature also synthesize cytokines and chemokines...
  46. pmc Opposing microtubule motors drive robust nuclear dynamics in developing muscle cells
    Meredith H Wilson
    Department of Physiology, Perelman School of Medicine at the University of Pennsylvania, D400 Richards Building, Philadelphia, PA 19104 6085, USA
    J Cell Sci 125:4158-69. 2012
    ..The three-dimensional rotation of myotube nuclei may facilitate their motility through the complex and crowded cellular environment of the developing muscle cell, allowing for proper myonuclear positioning...
  47. ncbi The UCS family of myosin chaperones
    Alex H Hutagalung
    Departments of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Sci 115:3983-90. 2002
    ..Although the mechanism of action of UCS proteins is unknown, recent biochemical studies suggest that they may act as molecular chaperones that facilitate the folding and/or maturation of myosin...
  48. ncbi Capsaicin stimulates glucose uptake in C2C12 muscle cells via the reactive oxygen species (ROS)/AMPK/p38 MAPK pathway
    Soon Hee Kim
    Nutrition and Metabolism Research Group, Korea Food Research Institute, Gyeonggi do 463 746, Republic of Korea
    Biochem Biophys Res Commun 439:66-70. 2013
    ..that capsaicin increases glucose uptake directly by activating AMP-activated protein kinase (AMPK) in C2C12 muscle cells, which manifested as an attenuation of glucose uptake when compound C, an AMPK inhibitor, was co-administered ..
  49. pmc Function-based discovery of significant transcriptional temporal patterns in insulin stimulated muscle cells
    Barbara Di Camillo
    Information Engineering Department, University of Padova, Padova, Italy
    PLoS ONE 7:e32391. 2012
  50. ncbi Endoplasmic reticulum stress does not mediate palmitate-induced insulin resistance in mouse and human muscle cells
    R Hage Hassan
    INSERM, UMR S 872, Centre de Recherche des Cordeliers, Paris 75006, France
    Diabetologia 55:204-14. 2012
    ..Since it has been shown that ER stress can interfere with insulin signalling, our hypothesis was that the deleterious action of palmitate on the insulin signalling pathway in muscle cells could also involve ER stress.
  51. ncbi Skeletal muscle LIM protein 1 (SLIM1/FHL1) induces alpha 5 beta 1-integrin-dependent myocyte elongation
    Meagan J McGrath
    Dept of Biochemistry and Molecular Biology, Monash Univ, Wellington Rd, Clayton, VIC 3800, Australia
    Am J Physiol Cell Physiol 285:C1513-26. 2003
    ..These results suggest that SLIM1 may play an important role during the early stages of skeletal muscle differentiation, specifically in alpha5beta1-integrin-mediated signaling pathways...
  52. ncbi Differential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile response
    Margaret V Westfall
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 280:41324-31. 2005
  53. ncbi Short-term activation of peroxysome proliferator-activated receptor beta/delta increases fatty acid oxidation but does not restore insulin action in muscle cells from type 2 diabetic patients
    Cyrille Debard
    INSERM U 449, INRA U 1235, R Laennec Faculty of Medicine, Human Nutrition Research Center, Claude Bernard Lyon 1 University, Rue G Paradin, 69372, Lyon, Cedex 08, France
    J Mol Med (Berl) 84:747-52. 2006
    ..of this study was to verify whether activation of fatty acid oxidation by PPARbeta agonists in human skeletal muscle cells prepared from type 2 diabetic patients could improve the reduced responses to insulin that characterized this ..
  54. ncbi Regulation of VEGF and bFGF mRNA expression and other proliferative compounds in skeletal muscle cells
    L Jensen
    Copenhagen Muscle Research Centre, Institute of Exercise and Sport Science, University of Copenhagen, Copenhagen, Denmark
    Angiogenesis 7:255-67. 2004
    ..effect of extracellular medium was determined in non-stimulated and electro-stimulated rat and human skeletal muscle cells. In rat skeletal muscle cells these aspects were also determined after treatment with inhibitors and/or donors ..
  55. pmc NEU3 sialidase is activated under hypoxia and protects skeletal muscle cells from apoptosis through the activation of the epidermal growth factor receptor signaling pathway and the hypoxia-inducible factor (HIF)-1α
    Raffaella Scaringi
    Department of Biomedical Sciences for Health, University of Milan, 20090 Segrate Milan, Italy
    J Biol Chem 288:3153-62. 2013
    ..sialidase, a key enzyme in ganglioside metabolism, is activated under hypoxic conditions in cultured skeletal muscle cells (C2C12)...
  56. ncbi Association between the muscle-specific proteins desmin and caveolin-3 in muscle cells
    Claudia S Mermelstein
    Departamento de Histologia e Embriologia, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Cell Tissue Res 327:343-51. 2007
    ..We have thus shown, for the first time, an association between the intermediate filament protein desmin and caveolin-3 in myogenic cells...
  57. pmc α-Catulin CTN-1 is required for BK channel subcellular localization in C. elegans body-wall muscle cells
    Bojun Chen
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA
    EMBO J 29:3184-95. 2010
    ..required for subcellular localization of SLO-1, the Caenorhabditis elegans BK channel α-subunit, in body-wall muscle cells. CTN-1 was identified in a genetic screen for mutants that suppressed a lethargic phenotype caused by ..
  58. ncbi Delineation of myotoxicity induced by 3-hydroxy-3-methylglutaryl CoA reductase inhibitors in human skeletal muscle cells
    Julia Sacher
    Center of Biomolecular Medicine and Pharmacology, Medical University of Vienna, Austria
    J Pharmacol Exp Ther 314:1032-41. 2005
    ..Here, we show that statins cause apoptosis in differentiated human skeletal muscle cells. The prototypical representative of statins, simvastatin, triggered sustained intracellular Ca(2+) transients, ..
  59. pmc Effects of eicosapentaenoic acid and docosahexaenoic acid on uncoupling protein 3 gene expression in C(2)C(12) muscle cells
    Mak Soon Lee
    Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120 750, Korea
    Nutrients 5:1660-71. 2013
    ..the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on UCP3 gene expression in C(2)C(12) muscle cells. EPA and DHA up-regulated UCP3 mRNA level in a dose-dependent manner and similarly increased UCP3 promoter ..
  60. ncbi Role of RalA downstream of Rac1 in insulin-dependent glucose uptake in muscle cells
    Shinsuke Nozaki
    Division of Molecular Biology, Kobe University Graduate School of Medicine, Chuo Ku, Kobe, Japan
    Cell Signal 24:2111-7. 2012 examine the involvement of RalA in Rac1 regulation of the translocation of GLUT4 to the plasma membrane in muscle cells. Ectopic expression of a constitutively activated RalA mutant indeed stimulated GLUT4 translocation, suggesting ..
  61. pmc Peroxisome proliferator-activated receptor-γ activation enhances insulin-stimulated glucose disposal by reducing ped/pea-15 gene expression in skeletal muscle cells: evidence for involvement of activator protein-1
    Paola Ungaro
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy
    J Biol Chem 287:42951-61. 2012
    ..Thus, ped/pea-15 is downstream of a major PPARγ-regulated inflammatory network. Repression of ped/pea-15 transcription might contribute to the PPARγ regulation of muscle sensitivity to insulin...
  62. ncbi Reprogramming of bone marrow mesenchymal stem cells into cardiomyocytes
    Keiichi Fukuda
    Institute for Advanced Cardiac Therapeutics, Institute of Integrated Medical Research 7S1 7S2, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    C R Biol 325:1027-38. 2002
    ..These findings indicated that cell transplantation therapy for the patients with heart failure might possibly be achieved using the regenerated cardiomyocytes from autologous bone marrow cells in the near future...
  63. ncbi Canonical TRP channels and mechanotransduction: from physiology to disease states
    Amanda Patel
    IPMC CNRS, Universite de Nice Sophia Antipolis, 660 route des Lucioles, 06560, Valbonne, France
    Pflugers Arch 460:571-81. 2010
    ..For instance, opening of the non-selective stretch-activated cation channels in smooth muscle cells is involved in the pressure-dependent myogenic constriction of resistance arteries...
  64. ncbi FATP4 contributes as an enzyme to the basal and insulin-mediated fatty acid uptake of C₂C₁₂ muscle cells
    Margarete Digel
    Molecular Cell Biology Laboratory Internal Medicine IV, University of Heidelberg, Heidelberg, Germany
    Am J Physiol Endocrinol Metab 301:E785-96. 2011
    ..Here, we investigated the function of FATP4 in basal and insulin mediated fatty acid uptake in C(2)C(12) muscle cells, a model system relevant for fatty acid metabolism...
  65. pmc Genetic dissection of ion currents underlying all-or-none action potentials in C. elegans body-wall muscle cells
    Ping Liu
    Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3401, USA
    J Physiol 589:101-17. 2011
    ..elegans body-wall myocytes generate all-or-none APs, which evoke Ca2+ release from the sarcoplasmic reticulum (SR), although the specific ion channels used for AP upstroke and repolarization differ...
  66. pmc Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca(2+)-calmodulin-dependent protein kinase II
    Jerry Curran
    Rush University, Chicago, IL, USA
    J Mol Cell Cardiol 49:25-32. 2010
    ..Treatment with ISO plus KN93 completely abolished this effect. The evidence suggests the ISO-dependent increase in SCaW activity in both healthy and failing myocytes is CaMKII-dependent, implicating CaMKII in arrhythmogenesis...
  67. pmc Peroxisome proliferator-activated receptor-gamma coactivator-1alpha overexpression increases lipid oxidation in myocytes from extremely obese individuals
    Leslie A Consitt
    Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina, USA
    Diabetes 59:1407-15. 2010
    To determine whether the obesity-related decrement in fatty acid oxidation (FAO) in primary human skeletal muscle cells (HSkMC) is linked with lower mitochondrial content and whether this deficit could be corrected via overexpression of ..
  68. ncbi Nampt/visfatin/PBEF affects expression of myogenic regulatory factors and is regulated by interleukin-6 in chicken skeletal muscle cells
    Susan M Krzysik-Walker
    Department of Poultry Science, The Pennsylvania State University, University Park, PA 16802, USA
    Comp Biochem Physiol A Mol Integr Physiol 159:413-21. 2011
    ..mL(-1)) decreased Nampt mRNA abundance. Collectively, these results demonstrate that Nampt, regulated in part by IL-6, alters the expression of key myogenic transcription factors and thereby may influence postnatal myogenesis...
  69. ncbi USP19-deubiquitinating enzyme regulates levels of major myofibrillar proteins in L6 muscle cells
    Priyanka Sundaram
    Department of Medicine, Polypeptide Laboratory, McGill University and the McGill University Health Centre Research Institute, Montreal, Canada
    Am J Physiol Endocrinol Metab 297:E1283-90. 2009
    ..To further explore the role of USP19, we used small interfering RNA (siRNA) in L6 muscle cells. Lowering USP19 by 70-90% in myotubes resulted in a 20% decrease in the rate of proteolysis and an 18% decrease ..
  70. ncbi Regulation of the human oxytocin receptor by nuclear factor-kappaB and CCAAT/enhancer-binding protein-beta
    Vasso Terzidou
    Parturition Research Group, Institute of Reproductive and Developmental Biology, Hammersmith Hospital Campus, Du Cane Road, East Acton, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 91:2317-26. 2006
  71. ncbi High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus
    Brian G Drew
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Circulation 119:2103-11. 2009
    ..We hypothesized that HDL modulates glucose metabolism via elevation of plasma insulin and through activation of the key metabolic regulatory enzyme, AMP-activated protein kinase, in skeletal muscle...
  72. ncbi Protection of dystrophic muscle cells with polyphenols from green tea correlates with improved glutathione balance and increased expression of 67LR, a receptor for (-)-epigallocatechin gallate
    Olivier M Dorchies
    Laboratory of Pharmacology, Geneva Lausanne School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland
    Biofactors 35:279-94. 2009
    ..Altogether our results demonstrate that GTP and EGCg protect muscle cells by scavenging H(2)O(2) and by improving the glutathione balance...
  73. ncbi Ear mesenchymal stem cells (EMSC) can differentiate into spontaneously contracting muscle cells
    Barbara Gawronska-Kozak
    Regenerative Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Cell Biochem 102:122-35. 2007
    ..markers (CD44, CD73) and stem cell marker Sca-1 and can be differentiated into spontaneously contracting muscle cells. Treatment of cells with epidermal growth factor (EGF) change their morphology from fibroblast shapes into ..
  74. pmc Downregulation of the Hsp90 system causes defects in muscle cells of Caenorhabditis elegans
    Andreas M Gaiser
    Department of Chemistry and Center for Integrated Protein Science Munich CIPSM and Technische Universität München, Munchen, Germany
    PLoS ONE 6:e25485. 2011
    ..Furthermore, aggregates of the myosin MYO-3 are visible in muscle cells, if DAF-21 is depleted, implying a role of Hsp90 in the maintenance of muscle cell functionality...
  75. pmc A method for the direct identification of differentiating muscle cells by a fluorescent mitochondrial dye
    Tetsuaki Miyake
    Department of Physiology, University of Toronto, Best Institute Medical Research, Toronto, Canada
    PLoS ONE 6:e28628. 2011
    Identification of differentiating muscle cells generally requires fixation, antibodies directed against muscle specific proteins, and lengthy staining processes or, alternatively, transfection of muscle specific reporter genes driving GFP ..
  76. ncbi [Lipopolysaccharide-mediated regulation of interleukin-6 in cultured human detrusor smooth muscle cells]
    J Neuhaus
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Leipzig AoR, Liebigstrasse 20, 04103 Leipzig
    Urologe A 46:1193-7. 2007
    ..The aim of the study is to define IL-6 target gene regulation in cultivated human detrusor smooth muscle cells.
  77. ncbi Apolipoprotein A-I stimulates AMP-activated protein kinase and improves glucose metabolism
    R Han
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, 200031, China
    Diabetologia 50:1960-8. 2007
    ..However, it is unknown whether APOA-I directly protects against diabetes. The aim of this study was to characterise the functional role of APOA-I in glucose homeostasis...
  78. pmc Nuclei of non-muscle cells bind centrosome proteins upon fusion with differentiating myoblasts
    Xavier Fant
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 4:e8303. 2009
    ..Concomitantly, proteins of the centrosome relocalize from the pericentriolar material to the outer surface of the nucleus. The mechanisms that govern this relocalization are largely unknown...
  79. pmc Quantification of rapid Myosin regulatory light chain phosphorylation using high-throughput in-cell Western assays: comparison to Western immunoblots
    Hector N Aguilar
    Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 5:e9965. 2010
  80. pmc Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells
    Tim Ting Chiu
    Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada
    Mol Biol Cell 21:3529-39. 2010
    ..We propose that Arp2/3 and cofilin coordinate a dynamic cycle of actin branching and severing at the cell cortex, essential for insulin-mediated GLUT4 translocation in muscle cells.
  81. pmc Aldehyde dehydrogenase activity identifies a population of human skeletal muscle cells with high myogenic capacities
    Karine Vauchez
    Inserm U974, Paris, France
    Mol Ther 17:1948-58. 2009
    ..Our results suggest that ALDH activity is a novel marker for a population of new human skeletal muscle progenitors presenting a potential for cell biology and cell therapy...
  82. ncbi Vitamin E protects the insulin sensitivity and redox balance in rat L6 muscle cells exposed to oxidative stress
    R Vinayaga Moorthi
    Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006, India
    Clin Chim Acta 367:132-6. 2006
    The effect of reactive oxygen species (ROS) on insulin action is unclear. This study was carried out to explore the effect of prolonged low grade oxidative stress and vitamin E treatment on cultured rat L6 muscle cells.
  83. ncbi Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training
    Frode Norheim
    Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway
    Am J Physiol Endocrinol Metab 301:E1013-21. 2011
    ..Our aim was to identify the most abundantly secreted proteins in cultures of human skeletal muscle cells and to monitor their expression in muscles of strength-training individuals...
  84. ncbi The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein
    Valeria Kowaljow
    Laboratorio de Neurogenética, Instituto de Investigacion, Médica Mercedes y Martín Ferreyra INIMEC CONICET, Cordoba, Argentina
    Neuromuscul Disord 17:611-23. 2007
    ..Overexpression of DUX4 induces cell death, induces caspase 3/7 activity and alters emerin distribution at the nuclear envelope. We propose that DUX4-mediated cell death contributes to the pathogenic pathway in FSHD...
  85. ncbi K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts
    L Chilton
    Dept of Bioengineering, Univ of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 288:H2931-9. 2005
    ..In combination, these results show that ventricular fibroblasts and myofibroblasts express a variety of K(+) channel alpha-subunits and demonstrate that Kir current can modulate RMP and alter essential physiological functions...
  86. pmc AMP-activated protein kinase-regulated activation of the PGC-1alpha promoter in skeletal muscle cells
    Isabella Irrcher
    Department of Biology, York University, Toronto, Ontario, Canada
    PLoS ONE 3:e3614. 2008
    ..Our data identify a novel AMPK-mediated regulatory pathway that regulates PGC-1alpha gene expression. This could represent a potential therapeutic target to control PGC-1alpha expression in skeletal muscle...
  87. pmc Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytes
    Jeffrey G Jacot
    Department of Bioengineering, University of California, San Diego, USA
    Biophys J 95:3479-87. 2008
    ..On very stiff substrates, this adaptation seems to involve RhoA kinase...
  88. pmc Endotoxin and interferon-gamma inhibit translation in skeletal muscle cells by stimulating nitric oxide synthase activity
    Robert A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Shock 32:416-26. 2009
    ..of the present study was to test the hypothesis that endogenous NO negatively affects translation in skeletal muscle cells after exposure to a combination of endotoxin (LPS) and interferon-gamma (IFN-gamma)...
  89. ncbi Degradation of sarcomeric and cytoskeletal proteins in cultured skeletal muscle cells
    Juntipa Purintrapiban
    Department of Animal Sciences, Oregon State University, Corvallis, OR 97331 6702, USA
    Comp Biochem Physiol B Biochem Mol Biol 136:393-401. 2003
    ..the proteasome and the lysosome in degradation of individual sarcomeric and cytoskeletal proteins in cultured muscle cells. Rat L8-CID muscle cells, in which we expressed a transgene calpain inhibitor (CID), were used in the study...
  90. pmc Neuroligin-deficient mutants of C. elegans have sensory processing deficits and are hypersensitive to oxidative stress and mercury toxicity
    Jerrod W Hunter
    Genetic Models of Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Dis Model Mech 3:366-76. 2010
    ..Our results suggest a possible link between genetic defects in synapse formation or function, and sensitivity to environmental factors in the development of autism spectrum disorders...
  91. ncbi Porcine peroxisome proliferator-activated receptor gamma induces transdifferentiation of myocytes into adipocytes
    Y H Yu
    Department of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan
    J Anim Sci 84:2655-65. 2006
    ..Therefore, the existence of serine 112 in PPARgamma may have a role in regulating adipocyte differentiation...
  92. ncbi Leptin expression in human primary skeletal muscle cells is reduced during differentiation
    Rigmor Solberg
    Department of Pharmacology, School of Pharmacy, University of Oslo, Oslo, Norway
    J Cell Biochem 96:89-96. 2005
    ..However, the expression of the leptin receptor (OB-Rb) mRNA, was unchanged during differentiation of the muscle cells. Administration of recombinant leptin had no effect on leptin, myogenin, myoD, or GLUT4 mRNA expressions during ..
  93. pmc Growth hormone promotes skeletal muscle cell fusion independent of insulin-like growth factor 1 up-regulation
    Athanassia Sotiropoulos
    Institut National de la Sante et de la Recherche Medicale, U810, and Faculté de Médecine Necker Enfants Malades, Universite Paris 5, F 75730 Paris, France
    Proc Natl Acad Sci U S A 103:7315-20. 2006
    ..Taken together, these data unravel a specific function of GH in the control of cell fusion, an essential process for muscle growth...
  94. ncbi Ceramide down-regulates System A amino acid transport and protein synthesis in rat skeletal muscle cells
    Russell Hyde
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee, UK
    FASEB J 19:461-3. 2005
    ..attenuate the basal and insulin-stimulated activity of the Na+-dependent System A amino acid transporter in rat muscle cells (L6 myotubes) by depletion of the plasma membrane abundance of SNAT2 (a System A isoform)...
  95. ncbi Rapid preparation of a plasma membrane fraction from adipocytes and muscle cells: application to detection of translocated glucose transporter 4 on the plasma membrane
    Shin Nishiumi
    Graduate School of Agricultural Science, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe, Hyogo 657 8501, Japan
    Biosci Biotechnol Biochem 71:2343-6. 2007
    The aim of this study was to establish a rapid preparation of plasma membrane from adipocytes and muscle cells to detect translocated glucose transporter (GLUT) 4...
  96. ncbi Oxidative stress-associated mitochondrial dysfunction in corticosteroid-treated muscle cells
    Yasushi Oshima
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Muscle Nerve 30:49-54. 2004
    ..Since these changes disappeared in the presence of SOD, dexamethasone primarily induced ROS generation, resulting in apoptosis. We speculate that this mechanism provides the basis of a pathophysiological model of corticosteroid myopathy...
  97. ncbi Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle
    Tim T Chiu
    Program in Cell Biology, The Hospital for Sick Children, Toronto, Canada
    Cell Signal 23:1546-54. 2011
    ..actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle...
  98. ncbi Measuring phospholipase D activity in insulin-secreting pancreatic beta-cells and insulin-responsive muscle cells and adipocytes
    Rosanna Cazzolli
    Department of Medicine, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Methods Mol Biol 462:241-51. 2009
    ..cellular PLD activity in secretagogue-stimulated insulin-secreting pancreatic beta-cells and also insulin-stimulated adipocyte and muscle cells, two of the principal insulin-responsive cell types controlling blood glucose levels.
  99. ncbi Immortalized skin fibroblasts expressing conditional MyoD as a renewable and reliable source of converted human muscle cells to assess therapeutic strategies for muscular dystrophies: validation of an exon-skipping approach to restore dystrophin in Duchen
    Soraya Chaouch
    Universite Pierre et Marie Curie Paris 06, UMRS 974, Paris F 75013, France
    Hum Gene Ther 20:784-90. 2009
    ..Cellular models seem straightforward to set up; however, the proliferative capacity of muscle cells isolated from dystrophic patients is limited, and in addition it is difficult to envisage the use of large ..
  100. ncbi Saffron (Crocus sativus L.) increases glucose uptake and insulin sensitivity in muscle cells via multipathway mechanisms
    Changkeun Kang
    College of Veterinary Medicine, Gyeongsang National University, Jinju 660 701, South Korea
    Food Chem 135:2350-8. 2012
    ..saffron through investigating its signaling pathways associated with glucose metabolism in C(2)C(12) skeletal muscle cells. Saffron strongly enhanced glucose uptake and the phosphorylation of AMPK (AMP-activated protein kinase)/ACC (..
  101. ncbi Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandins
    M Sussmann
    Institut fur Pharmakologie und Klinische Pharmakologie, Heinrich Heine Universitat Dusseldorf, Germany
    Circ Res 94:592-600. 2004
    ..The regulation of HA synthesis by vasodilatory prostaglandins was analyzed in human arterial smooth muscle cells (SMCs)...

Research Grants71

    David Poole; Fiscal Year: 2001
    Jianjie Ma; Fiscal Year: 2004
    ..Fulfillment of the experiments proposed in this project should provide further insights into the function and regulation of the CFTR Cl- channel, as well as the potential therapeutic interventiosn in cystic fibrosis. ..
  3. High fat feeding and intramyocellular lipid abnormality
    ZengKui Guo; Fiscal Year: 2005
    ..Thus, the proposed research will improve the understanding of the mechanism of insulin resistance and imcTG abnormalities in the obese rat that will benefit investigation of human obesity. ..
  4. Role of MG29 in E-C Coupling of Striated Muscles
    Jianjie Ma; Fiscal Year: 2006
    ..long term goal of this project is to understand the cellular and molecular function of MG29 in E-C coupling of muscle cells, specifically to test the hypothesis that MG29 is a key protein involved in the biogenesis of the T-tubule ..
  5. Dynamics of Oxygen Uptake in Contracting Single Myocytes
    CASEY KINDIG; Fiscal Year: 2003
    ..abstract_text> ..
  6. Store-Operated Calcium Entry and Apoptosis
    Jianjie Ma; Fiscal Year: 2010
    ..Knowledge on the molecular interactions between apoptosis mediators and cytosolic factors that control SOCE will enable us to establish therapeutic agents that target Ca signaling in cancer and degenerative diseases. ..
  7. SR Ca2+ ATPase, a determinant of cardiac contractility
    Muthu Periasamy; Fiscal Year: 2007
    ..As such, these studies are likely to suggest novel clinical strategies that might be pursued for the management of chronic heart failure in humans. [unreadable] [unreadable]..
  8. Targeting Antioxidant Therapy to Cardiac Mitochondria
    EVAN ABEL; Fiscal Year: 2006
    ..Once efficacy is determined, promising reagents can then be subjected to pharmacokinetic and toxicological analysis following systemic administration. ..
  9. Uterine Vascular Adaptation to Pregnancy
    Lubo Zhang; Fiscal Year: 2005
    ..Such an understanding has obvious clinical implications because the maladaptation of uterine circulation to pregnancy is associated with fetal developmental abnormalities and maternal cardiovascular disorders. ..
    Deborah Carlson; Fiscal Year: 2006
    ..The proposed work focuses on five specific aims to increase our understanding of the cellular events involved in burn and sepsis-related myocardial injury. ..
  11. Control of ATP Producing Pathways in Skeletal Muscle
    Brandon Walsh; Fiscal Year: 2005
    ..determine the role of metabolic channeling in setting the onset kinetics of oxidative phosphorylation, and 3.) determine the intracellular PO2 at which respiration becomes O2 dependent. ..
  12. Beta3-Adrenergic Receptor & Progression to Heart Failure
    Che Ping Cheng; Fiscal Year: 2006
    ..Thus, provide valuable new insight into the mechanism of the progression of functional impairment in CHF, and may assist in specifically targeting therapy for CHF. ..
  13. Cerebral artery Ca2+ signaling & subarachnoid hemorrhage
    George Wellman; Fiscal Year: 2009
    ..This study should significantly enhance current knowledge with respect to Ca2+signaling and constriction of cerebral arteries in health and disease and provide insight into possible new therapies for the treatment of cerebral vasospasm. ..
  14. Ion Channel Function in Arrhythmogenic Cardiac Cell
    PENELOPE ALTMAN BOYDEN; Fiscal Year: 2010
  15. Influence of Troponin I Phosphrylation by PKC on Contractile Function
    Margaret V Westfall; Fiscal Year: 2010
    ..The ability to restore relaxation by gene transfer of Asp-substituted cTnl will be examined in failing myocytes. These studies could aid in the development of therapies to improve relaxation during heart failure. ..
  16. Redox Signaling in Osteoblast Differentiation
    Nandini Ghosh Choudhury; Fiscal Year: 2009
    ..Understanding the signal transduction pathways of osteoblast differentiation may result in the development of therapeutic modalities for the human diseases where lack of bone formation is the pathology. ..
  17. Prenatal Cocaine Exposure and Cardiac Programming
    Lubo Zhang; Fiscal Year: 2009
    ..abstract_text> ..
    Donald Menick; Fiscal Year: 2008
  19. Sex in Myocarditis
    Sally Huber; Fiscal Year: 2008
    ..By understanding the factors controlling virus infection and induction of innate immunity, better mechanism for controlling viral disease should be possible. ..
  20. Engineered neuronal networks for drug screening
    Peter Molnar; Fiscal Year: 2008
    ..abstract_text> ..
    John Payne; Fiscal Year: 2008
  22. FASEB Summer Conference on: The Biology of Calpains in Health and Disease
    Melissa Spencer; Fiscal Year: 2007
    ..The proposed program will provide the forum by which the momentum in this field may be maintained. [unreadable] [unreadable] [unreadable] [unreadable]..
  23. Cell Cycle Related Transdifferentation Plasticity
    Mehrdad Abedi; Fiscal Year: 2007
    ..This project will explore the functional plasticity of marrow to transdifferentate into nonhematopoietic tissues (heart, skeletal muscle and in liver). ..
  24. Lamin A Mutation and Hutchinson-Gilford Progeria
    Howard Worman; Fiscal Year: 2008
    ..This project will establish how mutations in nuclear lamins A and C cause HGPS, and if inhibition of protein farnesylation is a potential therapeutic intervention. ..
  25. Ca2+ Waves and Arrhythmias
    PENELOPE BOYDEN; Fiscal Year: 2008
    ..abstract_text> ..
    Gustav Akk; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
    Douglas Mann; Fiscal Year: 2007
    ..Taken together, these studies will provide definitive new information with respect to the role of TGF-beta mediated Smad dependent signaling and myocardial fibrosis in an experimental model of sustained inflammation. ..
  28. Psychiatric Research Education Program(PREP)
    Carol Tamminga; Fiscal Year: 2007
    ..Together, these features place the UTSWMC Department of Psychiatry in an ideal position to stimulate and train the next generation of basic and clinical psychiatric researchers. ..
  29. Functional assessment of donor-host cell coupling
    MICHAEL RUBART VAN DER LOHE; Fiscal Year: 2009
    ..The studies proposed here will address fundamental hypotheses regarding the fate of donor cells following cellular transplantation into normal and injured hearts. ..
  30. Novel Methods for Cardiac Micro-Impedance Measurement
    Andrew Pollard; Fiscal Year: 2005
    ..abstract_text> ..
  31. CDI and Gamma Delta+ in Viral Myocarditis
    Sally Huber; Fiscal Year: 2005
    ..abstract_text> ..
  32. Adrenergic and Purinergic Regulation of Target Cells
    Paul A Insel; Fiscal Year: 2010
    Che Ping Cheng; Fiscal Year: 2004
    ..These studies are necessary to extend our knowledge about the mechanism in the development of ADCM and help target therapy for ADCM. ..
    Kim Heidenreich; Fiscal Year: 2004
  35. Arginase and Nitric Oxide in Atherosclerosis
    Louis Ignarro; Fiscal Year: 2004
    ..The feasibility of this approach is borne out by the extensive preliminary data that support the central hypothesis. ..
    Amy Davidoff; Fiscal Year: 2003
    ..The development of cellular insulin resistance is likely to be a key factor in the etiology of diabetic cardiomyopathy and may represent the recapitulation of fetal gene expression, as shown for hypertrophic myocardium. ..
    Gary Aistrup; Fiscal Year: 2003
    ..This novel action may have major implications, given the widespread clinical use of dihydropyridines and other calcium channel antagonists. Drug interactions of this type will be an important focus of the project. ..
  38. Epithelial-stromal cell interactions in breast cancer
    Kornelia Polyak; Fiscal Year: 2010
  39. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
    James Watras; Fiscal Year: 2002
    ..regulation, and specificity of IRI as an endogenous inhibitor of neuronal InsP3 gated Ca channels, and thus may provide a foundation for studies aimed at abnormalities underlying altered intracellular Ca regulation in pathological states ..
    Douglas Mann; Fiscal Year: 2002
    ..Mechanisms and countermeasures for cardiac apoptosis will be tested by Dr. Doug Mann, with emphasis on dilated cardiomyopathy triggered by overexpression of tumor necrosis factor alpha, and on investigations of human myocardium. ..
    Sally Huber; Fiscal Year: 2002
    ..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
  43. Lamin A in Adipocyte Differentation and Survival
    Howard Worman; Fiscal Year: 2004
    ..Confirmation of this hypothesis will have implications for the identification of new cellular targets to treat human obesity and diabetes mellitus. ..
  44. mAKAP-orchestrated phosphorylation events: regulation of PDE4D3
    Kimberly L Dodge Kafka; Fiscal Year: 2010
    ..This study will further our understanding of the molecular mechanism of cardiac hypertrophy and help to identify novel targets for drug design to aid in the treatment of hypertrophy. ..
  45. Beta-Adrenergic Receptors of S49 Lymphoma Cells
    Paul Insel; Fiscal Year: 2005
    ..Moreover, the results should prove applicable to the many other hormone and neurotransmitter receptors that link to G proteins. ..
    Michael Parmacek; Fiscal Year: 2005
    DESCRIPTION (Applicant's abstract): The capacity of vascular smooth muscle cells (SMCs) to modulate their response to arterial injury has been implicated in the pathogenesis of vascular proliferative syndromes including atherosclerosis ..
  47. Role of Stretch to Endothelial Pulse-Perfusion Response
    David Kass; Fiscal Year: 2005
    ..abstract_text> ..
  48. Molecular Basis of Myocardin Function in the Heart
    Michael S Parmacek; Fiscal Year: 2010
    ..Myocardin is a remarkably potent transcriptional expressed exclusively in the heart and smooth muscle cells (SMCs)...
  49. DUX4 and Facioscapulohumeral Muscular Dystrophy
    Howard Worman; Fiscal Year: 2004
    ..The results obtained for DUX4 will be compared to DUX1, a non-pathological paralogue expressed in normal muscle cells. The results of this Exploratory/Developmental [R21] project will establish if abnormal expression of DUX4 ..
  50. Effect of defined surfaces on cardiac myocyte physiology
    Peter Molnar; Fiscal Year: 2004
    ..concerning the effect of the surface characteristics of engineered materials on the physiology of cardiac muscle cells. With the new surface modification methods the biomaterial / host interface could be determined/or studied/..
  51. Intramolecular Regulation of Ryanodine Receptors
    Alexander Shtifman; Fiscal Year: 2004
    ..This work will provide novel information needed to better understand the process of EC coupling and also may shed new light on the nature of muscle disorders such as malignant hyperthermia. ..
  52. Signaling Pathways Mediating NCX1 Expression
    Donald Menick; Fiscal Year: 2004
    ..The therapeutic modulation of these targets may potentially reverse the endpoints associated with the disease phenotype. ..
  53. GPCRs: Evolving Concepts and Drug Discovery
    Paul Insel; Fiscal Year: 2004
    ..Attendees will thus have the chance to learn and discuss new cutting edge topics regarding GPCRs. ..
  54. Mechanisms of Myocardial Radiofrequency Scar Expansion
    Rupak Mukherjee; Fiscal Year: 2004
    ..abstract_text> ..
  55. Sex in Viral Myocarditis
    Sally Huber; Fiscal Year: 2004
    ..These studies may provide new insights as to how viruses affect developing host defense responses and how hormones can modulate this initial response. ..
    Katherine High; Fiscal Year: 2001
    ..These studies will involve a collaboration between the P.I.'s lab and the laboratory of Dr. Hildegund Ertl, an immunologist with experience in characterizing immune responses in the setting of viral vectors. ..
    STEPHEN KNISLEY; Fiscal Year: 2001
    ..It will provide much improved capability in evaluating the extent and characterization of breast cancers for staging purposes that have been found useful in the surgical management of breast cancer. ..
  58. Actions of Ethanol on Ligand-Gated Ion Channels
    Gustav Akk; Fiscal Year: 2006
    ..The results from the experiments will be used to examine the mechanism and structural requirements in the ethanol-mediated modulation of the GABAA receptor function. ..
  59. Trypanosoma cruzi and AIDS: Role of the Adipocyte
    Herbert Tanowitz; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  60. Cardiovascular Stiffening in Aged Patients with CHF
    David Kass; Fiscal Year: 2005
    ..This could lead to new therapeutic approaches to this difficult clinical problem that affects a growing aged patient population. ..
  61. Novel epoxide hydrolase inhibitor for stroke prevention
    JOHN IMIG; Fiscal Year: 2005
    ..In the Phase II work, Arete Therapeutics will use the collected information to progress toward clinical trials in the area of stroke and possible new therapeutic avenues. ..
  62. Diastolic Function in Hypertrophic Cardiomyopathy
    Carolyn Ho; Fiscal Year: 2003
    ..Such genotype-phenotype correlations have the potential to improve our ability to risk stratify and monitor patients, and may ultimately inspire noel approaches to management. ..
    Robert Cox; Fiscal Year: 2007
    Voltage-gated K+ (Kv) currents in native vascular smooth muscle cells (VSMC) are inhibited by an increase in cytosolic free Ca2+, secondary to intracellular Ca 2+ release or extracellular Ca2+ influx...
    ..abstract_text> ..
  65. The ER Stress Response and ATF6 Activation in the Heart
    ..The ERSR has gone virtually unstudied in the heart; accordingly, the proposed studies are novel and will enhance our understanding of the ERSR and the roles played by ATF6 alpha and beta in the stressed myocardium. ..
  66. Impact of feeding on brain response to food stimuli in lean and obese subjects
    Marie Pierre St Onge; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
    SANDRA HASLAM; Fiscal Year: 2007
    ..The long-term goal of this proposal is the delineation of the mechanisms of P-dependent growth regulation in the adult normal mammary gland that may lead to novel strategies for the prevention and treatment of breast cancer. ..
  68. Examination of the Limbic Cortex in Schizophrenia
    Carol Tamminga; Fiscal Year: 2006
    ..These data will have implications for understanding the mechanisms of the illness and for directing future new drug discovery for schizophrenia therapeutics. ..
  69. Comparitive Antipsychotic Drug Actions on Brain Neurochemistry
    Carol Tamminga; Fiscal Year: 2007
    ..Concentration on mouse behaviors, neurochemistry and behavior will advance studies aimed at kinetic applications. ..
    Herbert Tanowitz; Fiscal Year: 2005
    ..cruzi activates the NF-KappaB pathway in endothelial and vascular smooth muscle cells by investigating the role of the generation of reactive oxygen species and cytoplasmic phospholipase A2 ..