kb cells

Summary

Summary: This line KB is now known to be a subline of the ubiquitous KERATIN-forming tumor cell line HeLa. It was originally thought to be derived from an epidermal carcinoma of the mouth, but was subsequently found, based on isoenzyme analysis, HeLa marker chromosomes, and DNA fingerprinting, to have been established via contamination by HELA CELLS. The cells are positive for keratin by immunoperoxidase staining. KB cells have been reported to contain human papillomavirus18 (HPV-18) sequences.

Top Publications

  1. ncbi Leuconoxine, kopsinitarine, kopsijasmine, and kopsinone derivatives from Kopsia
    Siew Huah Lim
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Nat Prod 70:1380-3. 2007
  2. pmc JNK signaling maintains the mesenchymal properties of multi-drug resistant human epidermoid carcinoma KB cells through snail and twist1
    Xia Zhan
    Department of Pharmacology, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, PR China
    BMC Cancer 13:180. 2013
  3. pmc Synthesis and evaluation of a novel ligand for folate-mediated targeting liposomes
    Guangya Xiang
    Pharmacy School, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Int J Pharm 356:29-36. 2008
  4. ncbi Rotenone inhibits the mitochondrial permeability transition-induced cell death in U937 and KB cells
    C Chauvin
    , , 38041 Grenoble, France
    J Biol Chem 276:41394-8. 2001
  5. pmc Preferential killing of multidrug-resistant KB cells by inhibitors of glucosylceramide synthase
    K M Nicholson
    Department of Biology, University of York, UK
    Br J Cancer 81:423-30. 1999
  6. ncbi Essential oil of Artemisia capillaris induces apoptosis in KB cells via mitochondrial stress and caspase activation mediated by MAPK-stimulated signaling pathway
    Jeong Dan Cha
    Oral Cancer Research Inst, College of Dentistry, Yonsei Univ, Seoul, South Korea
    J Food Sci 74:T75-81. 2009
  7. ncbi The ribonucleotide reductase subunit M2B subcellular localization and functional importance for DNA replication in physiological growth of KB cells
    Xiyong Liu
    Department of Medical Oncology and Therapeutic Research, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010 3000, USA
    Biochem Pharmacol 70:1288-97. 2005
  8. ncbi Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters
    Amit K Tiwari
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
    Biochem Pharmacol 78:153-61. 2009
  9. ncbi Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells
    Songyot Anuchapreeda
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Thailand 50200
    Biochem Pharmacol 64:573-82. 2002
  10. ncbi Solamargine, a steroidal alkaloid glycoside, induces oncosis in human K562 leukemia and squamous cell carcinoma KB cells
    Lingmei Sun
    School of Pharmaceutical Sciences, Shandong University, No 44 West Wenhua Road, Jinan, China
    Cancer Chemother Pharmacol 67:813-21. 2011

Detail Information

Publications198 found, 100 shown here

  1. ncbi Leuconoxine, kopsinitarine, kopsijasmine, and kopsinone derivatives from Kopsia
    Siew Huah Lim
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Nat Prod 70:1380-3. 2007
    ..teoi. The structures of these alkaloids were determined using NMR and MS analysis. Kopsijasminine (3) showed moderate activity in reversing multidrug resistance in vincristine-resistant KB cells.
  2. pmc JNK signaling maintains the mesenchymal properties of multi-drug resistant human epidermoid carcinoma KB cells through snail and twist1
    Xia Zhan
    Department of Pharmacology, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, PR China
    BMC Cancer 13:180. 2013
    ....
  3. pmc Synthesis and evaluation of a novel ligand for folate-mediated targeting liposomes
    Guangya Xiang
    Pharmacy School, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Int J Pharm 356:29-36. 2008
    ..The liposomes were taken up selectively by KB cells, which overexpress FR-alpha...
  4. ncbi Rotenone inhibits the mitochondrial permeability transition-induced cell death in U937 and KB cells
    C Chauvin
    , , 38041 Grenoble, France
    J Biol Chem 276:41394-8. 2001
    ..chain complex I have been reported, we have investigated the effects of rotenone on PTP regulation in U937 and KB cells. We show that rotenone was more potent than cyclosporin A at inhibiting Ca(2+)-induced PTP opening in digitonin-..
  5. pmc Preferential killing of multidrug-resistant KB cells by inhibitors of glucosylceramide synthase
    K M Nicholson
    Department of Biology, University of York, UK
    Br J Cancer 81:423-30. 1999
    ..These results suggest that the manipulation of glucosylceramide levels may be a fruitful way of causing the preferential killing of MDR cells in vitro and possibly in vivo...
  6. ncbi Essential oil of Artemisia capillaris induces apoptosis in KB cells via mitochondrial stress and caspase activation mediated by MAPK-stimulated signaling pathway
    Jeong Dan Cha
    Oral Cancer Research Inst, College of Dentistry, Yonsei Univ, Seoul, South Korea
    J Food Sci 74:T75-81. 2009
    ..The essential oil induced cell death of KB cells through apoptosis, as evidenced by the increased cell population in the sub-G1 phase, the appearance of condensed ..
  7. ncbi The ribonucleotide reductase subunit M2B subcellular localization and functional importance for DNA replication in physiological growth of KB cells
    Xiyong Liu
    Department of Medical Oncology and Therapeutic Research, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010 3000, USA
    Biochem Pharmacol 70:1288-97. 2005
    ..A living cell sorting study that used KB cells in normal growth, further confirmed that M2B increased to maximum levels at the G(1)/S-phase transition, and ..
  8. ncbi Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters
    Amit K Tiwari
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
    Biochem Pharmacol 78:153-61. 2009
    ..Also, these findings may be useful in clinical practice for cancer combination therapy with nilotinib...
  9. ncbi Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells
    Songyot Anuchapreeda
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Thailand 50200
    Biochem Pharmacol 64:573-82. 2002
    ..In summary, this study describes the duel modulation of MDR1 expression and Pgp function by the phytochemical curcumin, which may be an attractive new agent for the chemosensitization of cancer cells...
  10. ncbi Solamargine, a steroidal alkaloid glycoside, induces oncosis in human K562 leukemia and squamous cell carcinoma KB cells
    Lingmei Sun
    School of Pharmaceutical Sciences, Shandong University, No 44 West Wenhua Road, Jinan, China
    Cancer Chemother Pharmacol 67:813-21. 2011
    ..The aim of this study was to demonstrate that solamargine (SM) mediates its cytotoxicity via oncosis...
  11. ncbi Reversing effect of agosterol A, a spongean sterol acetate, on multidrug resistance in human carcinoma cells
    S Aoki
    Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan
    Jpn J Cancer Res 92:886-95. 2001
    ..We conclude that agosterol A directly inhibited drug efflux through P-gp and/or MRP1...
  12. ncbi Time and sequence dependence of hydroxyurea in combination with gemcitabine in human KB cells
    Bingsen Zhou
    Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA
    Anticancer Res 22:1369-77. 2002
    ..Exposure of human oropharyngeal carcinoma KB cells to HU followed by the addition of Gem at various times significantly enhanced cytotoxicity when compared to ..
  13. ncbi ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum
    E Mongelli
    PROPLAME CONICET, Departamento de Quimica Organica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellon 2, Universidad de Buenos Aires 1428, Buenos Aires, Argentina
    Phytother Res 16:387-8. 2002
    ..This compound was potent against the brine shrimp (LC(50) = 4.8 microg/mL) and KB cells (IC(50) = 1.6 microg/mL).
  14. ncbi Tumour cell uptake of the metastasis inhibitor ruthenium complex NAMI-A and its in vitro effects on KB cells
    Fabiana Frausin
    Callerio Foundation Onlus, Via A Fleming 22 31, 34127 Trieste, Italy
    Cancer Chemother Pharmacol 50:405-11. 2002
    The uptake of NAMI-A (imidazolium trans-imidazoledimethylsulphoxidetetrachlororuthenate) by KB cells in vitro was compared with the effects of this compound on the cell cycle phase distribution of the cells.
  15. pmc Purified membrane and soluble folate binding proteins from cultured KB cells have similar amino acid compositions and molecular weights but differ in fatty acid acylation
    C A Luhrs
    Proc Natl Acad Sci U S A 84:6546-9. 1987
    ..binding protein (FBP) and a soluble FBP, which is released into the culture medium, have been purified from human KB cells using affinity chromatography. By NaDodSO4/PAGE, both proteins have an apparent Mr of approximately 42,000...
  16. ncbi Triptolide circumvents drug-resistant effect and enhances 5-fluorouracil antitumor effect on KB cells
    Yuan Wu Chen
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taiwan, Republic of China
    Anticancer Drugs 21:502-13. 2010
    ..In this study, we show that triptolide possesses an anticancer effect on drug-sensitive parental KB cells and multidrug-resistant KB-7D and KB-tax cells that overexpress multidrug resistance protein and MDR, ..
  17. ncbi Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistance
    Liwu Fu
    Cancer Center, Sun Yat Sen University, 510060 Guangzhou, China
    Cancer Chemother Pharmacol 53:349-56. 2004
    ..625 micromol/l produced a 7.6-fold reversal of MDR, but showed no effect on the sensitivity of drug-sensitive KB cells in vitro. In the KBv200 cell xenograft model in nude mice, neither Tet nor VCR inhibited tumor growth...
  18. ncbi 1p31, 7q21 and 18q21 chromosomal aberrations and candidate genes in acquired vinblastine resistance of human cervical carcinoma KB cells
    Jin Wang
    Department of Biology and Chemistry, City University of Hong Kong, Hong Kong, PR China
    Oncol Rep 19:1155-64. 2008
    ..This study also demonstrates that the combination of CGH and cDNA microarray is a very useful tool to detect drug resistant targets in cancer treatment...
  19. ncbi Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer
    Jolanta F Kukowska-Latallo
    University of Michigan Center for Biologic Nanotechnology, Ann Arbor, Michigan, USA
    Cancer Res 65:5317-24. 2005
    ..Targeting methotrexate increased its antitumor activity and markedly decreased its toxicity, allowing therapeutic responses not possible with a free drug...
  20. pmc Comparison of the internalization of targeted dendrimers and dendrimer-entrapped gold nanoparticles into cancer cells
    Xiangyang Shi
    State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 2999 North Renmin Road, Shanghai 201620, People s Republic of China
    Biopolymers 91:936-42. 2009
    ..This study underlines the fact that metal or inorganic NPs entrapped within dendrimers interact with cells in a similar way to that of dendrimers lacking host NPs...
  21. ncbi New taxane diterpenoids from the leaves and twigs of Taxus sumatrana
    Ya Ching Shen
    Institute of Marine Resources, National Sun Yat Sen University, 70 Lien Hai Road, Kaohsiung, Taiwan 80424, Republic of China
    J Nat Prod 65:1848-52. 2002
    ..Taxuspine F and compound 5 possessed moderate activity against Hepa cells only, while 3, 6, 7, and 10-deacetylbaccatin III showed only marginal activity against Hepa cells...
  22. ncbi Targeting and inhibition of cell growth by an engineered dendritic nanodevice
    Thommey P Thomas
    Center for Biologic Nanotechnology, University of Michigan Medical School, 9220 MSRB III, Ann Arbor, Michigan 48109 0648, USA
    J Med Chem 48:3729-35. 2005
    ..This trifunctional dendrimer-drug conjugate bound to FA receptor-expressing KB cells in a dose-dependent and saturable manner...
  23. ncbi 6-Hydroxymanzamine A and 3,4-dihydromanzamine A, new alkaloids from the Okinawan marine sponge Amphimedon Sp
    J Kobayashi
    Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    J Nat Prod 57:1737-40. 1994
    ..Two new beta-carboline alkaloids, 6-hydroxymanzamine A [1] and 3,4-dihydromanzamine A [2], have been isolated from the Okinawan marine sponge Amphimedon sp. and their structures elucidated on the basis of nmr spectral data...
  24. ncbi Lgf-YL-9 induces apoptosis in human epidermoid carcinoma KB cells and multidrug resistant KBv200 cells via reactive oxygen species-independent mitochondrial pathway
    Xiao Hong Wang
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou 510060, PR China
    Cancer Lett 249:256-70. 2007
    ..the effect of Lgf-YL-9 on cytotoxicity and cell apoptosis in human epidermoid carcinoma drug-sensitive parental KB cells and multidrug resistant (MDR) KBv200 cells...
  25. ncbi [Apoptosis of human carcinoma of mouth floor KB cells and multidrug resistant KBv200 cells induced by azide methyl anthraquinone derivative]
    Yan Ding
    Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Yao Xue Xue Bao 40:22-6. 2005
    To determine the effects of azide methyl anthraquinone derivative (AMAD) on growth inhibition and inducing apoptosis of multidrug resistant (MDR) KBv200 cells and parental drug-sensitive KB cells.
  26. ncbi Survivin may enhance DNA double-strand break repair capability by up-regulating Ku70 in human KB cells
    Gaofeng Jiang
    Faculty of Preventive Medicine, Medical College, Huangjiahu Campus, Wuhan University of Science and Technology, Wuhan 430065, PR China
    Anticancer Res 29:223-8. 2009
    ..This study was conducted to investigate whether survivin plays a role in the DNA repair process in the KB human squamous cell carcinoma cell line...
  27. ncbi Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome
    E Strozyk
    Department of Dermatology, University of Muenster, Muenster, Germany
    Oncogene 25:6239-51. 2006
    ..This may have implications for the role of NF-kappaB in carcinogenesis and for the application of NF-kappaB inhibitors in anticancer therapy...
  28. ncbi PAMAM dendrimer-based multifunctional conjugate for cancer therapy: synthesis, characterization, and functionality
    Istvan J Majoros
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, 200 Zina Pitcher Place, 4027 Kresge II, Ann Arbor, 48109 0533, USA
    Biomacromolecules 7:572-9. 2006
    ..We present here the synthesis, characterization, and functionality of these dendrimer conjugates...
  29. ncbi Experimental chemotherapy against xenografts derived from multidrug resistant KBv200 cells and parental drug-sensitive KB cells in nude mice by annonaceous acetogenin 89-2
    Li Wu Fu
    Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Yao Xue Xue Bao 38:565-70. 2003
    Annonaceous acetogenin 89-2 was obtained from atemoya plant. To investigate the effect of 89-2 on experimental chemotherapy against xenografts derived from multidrug resistant KBv200 cells and parental drug-sensitive KB cells.
  30. ncbi Porphyromonas gingivalis survives within KB cells and modulates inflammatory response
    S Eick
    Department of Medical Microbiology, University Hospital of Jena, Jena, Germany
    Oral Microbiol Immunol 21:231-7. 2006
    ..The purpose of the study was to investigate the intracellular survival of Porphyromonas gingivalis as a possible mechanism for maintaining periodontitis...
  31. ncbi DNA damaging drugs-induced down-regulation of Bcl-2 is essential for induction of apoptosis in high-risk HPV-positive HEp-2 and KB cells
    Sandeep Singh
    National Centre for Cell Science, NCCS Complex, Ganeshkhind, Pune 411 007, India
    Cancer Lett 236:213-21. 2006
    ..targets, induce apoptosis in various cancer cells including human papillomavirus (HPV) positive HEp-2 and KB cells. The present work reports the involvement of Bcl-2 in response to the exposure of HEp-2 and KB cells to Carb or 5-..
  32. ncbi Cellular uptake of trivalent arsenite and pentavalent arsenate in KB cells cultured in phosphate-free medium
    R N Huang
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China
    Toxicol Appl Pharmacol 136:243-9. 1996
    ..Our results also show that As(III) and As(V) are excreted from KB cells at a comparable rate, and at least half of As(V) is reduced to the more toxic As(III) prior to excretion into the ..
  33. ncbi SDZ PSC 833, the cyclosporine A analogue and multidrug resistance modulator, activates ceramide synthesis and increases vinblastine sensitivity in drug-sensitive and drug-resistant cancer cells
    M C Cabot
    John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, California 90404, USA
    Cancer Res 59:880-5. 1999
    ..These data demonstrate that PSC 833 has mechanisms of action in addition to P-glycoprotein chemotherapy efflux pumping...
  34. ncbi MAPK activation is necessary to the apoptotic death of KB cells induced by the essential oil isolated from Artemisia iwayomogi
    Jeong Dan Cha
    Oral Cancer Research Institute, College of Dentistry, Yonsei University, Seoul 120 749, Republic of Korea
    J Ethnopharmacol 123:308-14. 2009
    ..Previously, the purified essential oil was isolated from Artemisia iwayomogi, herein named AIEO, and found to contain the active components responsible for the chemopreventive potential of the herb...
  35. ncbi Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo
    Yuan Wu Chen
    Graduate Institute of Medical Sciences, National Defense Medical Center, No 161, Section 6, Min Chuan East Road, Neihu 114, Taipei 114, Taiwan, ROC
    Oral Oncol 45:562-8. 2009
    ..that TPL induces prominent growth inhibition and apoptosis in two oral cancer cell lines, SCC25 and OEC-M1 and in KB cells. Our results indicate that TPL induces a dose-dependent apoptosis of these cells at nanomolar concentration...
  36. ncbi 5-Fluorouracil inhibits dihydrofolate reductase precursor mRNA processing and/or nuclear mRNA stability in methotrexate-resistant KB cells
    C L Will
    Department of Experimental Therapeutics, Roswell Park Memorial Institute, Buffalo, New York 14263
    J Biol Chem 264:21413-21. 1989
    ..8-fold in FUra-treated cells. These results provide further evidence the FUra may inhibit processing of mRNA precursors and/or affect the stability of nuclear DHFR mRNA...
  37. ncbi Individual adenovirus E1B proteins induce transformation independently but by additive pathways
    W McLorie
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    J Gen Virol 72:1467-71. 1991
    ..These results indicate that transformation mediated by either E1B product can proceed independently, but that the processes involved are additive...
  38. ncbi Interaction of Porphyromonas gingivalis with KB cells: comparison of different clinical isolates
    S Eick
    Department of Medical Microbiology, University Hospital of Jena, Jena, Germany
    Oral Microbiol Immunol 17:201-8. 2002
    ..of different Porphyromonas gingivalis strains (15 clinical isolates and ATCC 33277) to attach to and invade KB cells, in relation to other properties such as release of interleukin (IL)-6 and IL-8, cytotoxicity, proteolytic ..
  39. ncbi Cytotoxic diterpenoids from the soft coral Sinularia microclavata
    Cui Xian Zhang
    School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou, 510275, People s Republic of China
    J Nat Prod 68:1087-9. 2005
    ..0 and 20.0 microg/mL, respectively, and capillolide (2) showed potent cytotoxic activity against tumor cell lines (A-549) with an IC50 value of 0.5 microg/mL...
  40. ncbi 19-Nor- and 18,20-epoxy-cardenolides from the leaves of Calotropis gigantea
    Thitima Lhinhatrakool
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkapi, Bangkok 10240, Thailand
    J Nat Prod 69:1249-51. 2006
    ..The presence of a deoxysugar at C-3, a formyl group at C-10, and an alpha,beta-unsaturated gamma-lactone was crucial for cytotoxic activity...
  41. ncbi Oxygenated terpenoids from a formosan soft coral Sinularia gibberosa
    Atallah F Ahmed
    Department of Marine Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 68:1208-12. 2005
    ..Metabolites 2 and 4 were found to exhibit moderate cytotoxicity toward a human liver carcinoma cell line...
  42. ncbi Eudesmane derivatives and other sesquiterpenes from Laggera alata
    Qun Xiong Zheng
    Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, and Institute of Hangzhou Commerce, Hangzhou, People s Republic of China
    J Nat Prod 66:1078-81. 2003
    ..Their structures were elucidated primarily by NMR and mass spectroscopic methods. The structures of 1 and 2 were confirmed by X-ray crystallography...
  43. ncbi Characterization of lipophilic pentasaccharides from beach morning glory (Ipomoea pes-caprae)
    Rogelio Pereda-Miranda
    Departamento de Farmacia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico City 04510 DF, Mexico
    J Nat Prod 68:226-30. 2005
    ..All the isolated compounds (1-6), characterized through high-field NMR spectroscopy, were found to be weakly cytotoxic to a small panel of cancer cell lines...
  44. ncbi Cytotoxic monotetrahydrofuran acetogenins from Disepalum plagioneurum
    Véronique Eparvier
    Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 1 Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    J Nat Prod 69:1289-94. 2006
    ..The new monotetrahydrofuran (mono-THF) acetogenins exhibited significant in vitro cytotoxicity against the KB cancer cell line, with IC(50) values in the nanomolar range...
  45. ncbi Triterpenoid saponin anthranilates from Albizia grandibracteata leaves ingested by primates in Uganda
    Sabrina Krief
    Laboratoire de Pharmacognosie, FRE CNRS 2715, IFR 53 Biomolecules, Reims, France
    J Nat Prod 68:897-903. 2005
    ..This is the first report of such ester saponins in dicotyledonous plants. Studies of the primate diet may provide a useful method for finding naturally occurring compounds of medicinal significance...
  46. ncbi Cytotoxic diterpenoids from the soft coral Sarcophyton crassocaule
    Cuixian Zhang
    School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou, 510275, People s Republic of China
    J Nat Prod 69:1476-80. 2006
    ..0, 4.0, and 5.0 microg/mL, respectively, while compounds 1 and 5 showed moderate cytotoxicity toward KB cell lines with IC50 values of 19.0 and 13.0 microg/mL, respectively...
  47. ncbi New antimycobacterial and antimalarial 8,9-secokaurane diterpenes from Croton kongensis
    Jirabhorn Thongtan
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    J Nat Prod 66:868-70. 2003
    ..9 to 3.2 microg/mL), KB (IC(50) from 1.2 to 13.8 microg/mL), and BC cell lines (IC(50) from 1.1 to 2.2 microg/mL, except for compound 1, which was inactive against BC cells)...
  48. ncbi Two unusual acetogenins from the roots of Annona salzmanii
    Emerson F Queiroz
    Laboratoire de Pharmacognosie, CNRS UPRES A 8076 BIOCIS, Faculte de Pharmacie, 92296 Chatenay Malabry, France
    J Nat Prod 66:755-8. 2003
    ..Compounds 1 and 2 showed significant activity against the KB and Vero cell lines...
  49. ncbi Triterpenoids from the floral spikes of Betula platyphylla var. japonica and their reversing activity against multidrug-resistant cancer cells
    Yoshiki Kashiwada
    Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1 78, Tokushima 770 8505, Japan
    J Nat Prod 70:623-7. 2007
    ..Compound 10 reversed the cytotoxicity of colchicine against KB-C2 cells at 8.1 microM and showed comparable potency to 5 microM verapamil...
  50. ncbi Furanolabdane diterpenes from Hypoestes purpurea
    Chien Chang Shen
    National Research Institute of Chinese Medicine, NO 155 1, Sec 2, Li Nung Street, Peitou, Taipei, Taiwan
    J Nat Prod 67:1947-9. 2004
    ..The structures of 1-4 were elucidated mainly on the basis of NMR and MS. Compound 1 was found to be moderately cytotoxic toward the KB cell line with an IC(50) value of 9.4 microM...
  51. ncbi Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata
    Ping Chung Kuo
    Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, Republic of China
    Org Lett 8:2953-6. 2006
    ..Physalins B (4), D (5), and F (6) showed strong cytotoxicity against multiple tumor cell lines, including KB, A431, HCT-8, PC-3, and ZR751, with EC(50) values less than 4 microg/mL...
  52. ncbi Cytotoxic constituents of the twigs and leaves of Aglaia rubiginosa
    J Fausto Rivero-Cruz
    Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Nat Prod 67:343-7. 2004
    ..The structures of 1 and 5 were elucidated by spectral and chemical methods. Isolates were evaluated with a human cancer cell panel, and compounds 1-4 were found to exhibit potent cytotoxic activity...
  53. ncbi Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines
    Chi I Chang
    Graduate Institute of Biotechnology, National Pingtung University of Science and Technology, Pingtung, Taiwan 912, Republic of China
    J Nat Prod 67:91-3. 2004
    ..All three new triterpenes showed significant cytotoxicity against two human tumor cell lines, namely, oral epidermoid carcinoma KB and colorectal carcinoma HT29, and gave IC(50) values in the range 1.2-3.6 microM...
  54. ncbi Pseudoguanolide sesquiterpene lactones from Vernoniopsis caudata and their in vitro antiplasmodial activities
    Voahangy Ramanandraibe
    Laboratoire de Pharmacognosie Appliquée aux Maladies Infectieuses, Institut Malgache de Recherches Appliquees, BP 3833, 101 Antananarivo, Madagascar
    J Nat Prod 68:800-3. 2005
    ..19, and 0.41 microM, respectively. However, these compounds also exhibited considerable cytotoxicity on KB cells (IC50 < 1 microM in each case).
  55. ncbi Cytotoxic sesquiterpene lactones from Eupatorium kiirunense, a coastal plant of Taiwan
    Ya Ching Shen
    Institute of Marine Resources, National Sun Yat Sen University, 70 Lien Hai Road, Kaohsiung, Taiwan 80424, Republic of China
    J Nat Prod 68:745-50. 2005
    ..Compounds 6, 8, and 9 exhibited cytotoxicity against human oral epidermoid (KB), cervical epitheloid (Hela), and liver (hepa59T/VGH) carcinoma cells...
  56. ncbi Four new triterpenoids from Maytenus ilicifolia
    Ayumi Ohsaki
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda ku, Tokyo 101 0062, Japan
    J Nat Prod 67:469-71. 2004
    ..Of these triterpenoids only erythrodiol exhibited significant cytotoxicity against KB/S, KB/VJ300, and KU 19-20 cells...
  57. ncbi Lakoochins A and B, new antimycobacterial stilbene derivatives from Artocarpus lakoocha
    Apirak Puntumchai
    Department of Chemistry, Faculty of Science, Mahidol University, Thailand
    J Nat Prod 67:485-6. 2004
    ..1 microg/mL) but inactive (at 20 microg/mL) toward KB (nasopharyngeal carcinoma) cells, compound 2 possessed cytotoxicity against the BC and KB cell lines with IC(50) values of 3.1 and 6.1 microg/mL, respectively...
  58. ncbi Constituents of the leaves and twigs of Calyptranthes pallens collected from an experimental plot in Southern Florida
    Tatiana Lobo-Echeverri
    Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Nat Prod 68:577-80. 2005
    ..Several known compounds of the ellagic acid, lignan, phloroglucinol, sterol, and triterpene types were also obtained in the present investigation...
  59. ncbi Pentacyclic triterpenoid esters from the fruits of Bruguiera cylindrica
    Surat Laphookhieo
    Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
    J Nat Prod 67:886-8. 2004
    ..Compounds 2 and 6 exhibited weak cytotoxicity against the NCI-H187 cell line...
  60. ncbi Chamuvarinin, an acetogenin bearing a tetrahydropyran ring from the roots of Uvaria chamae
    Djibril Fall
    Laboratoire de Pharmacognosie, UMR 8076 CNRS BioCIS, Faculte de Pharmacie, Universite Paris XI, 92296 Chatenay Malabry, France
    J Nat Prod 67:1041-3. 2004
    ..This new compound shows significant cytotoxicity toward the KB 3-1 cell line (IC50 = 8 x 10(-10) M). In addition, a biosynthetic relationship between 1 and 2 is briefly discussed...
  61. ncbi Sensitization of multidrug resistant (MDR) cancer cells to vinblastine by novel acridones: correlation between anti-calmodulin activity and anti-MDR activity
    Y C Mayur
    Department of Chemistry, Western Illinois University, 1 University Circle, Currens Hall, Macomb, IL 61455, USA
    Med Chem 2:63-77. 2006
    ....
  62. ncbi Tasipeptins A and B: new cytotoxic depsipeptides from the marine cyanobacterium Symploca sp
    Philip G Williams
    Department of Chemistry, University of Hawaii at Manoa, Honolulu 96822, USA
    J Nat Prod 66:620-4. 2003
    ..Tasipeptins A (1) and B (2) were cytotoxic toward KB cells with IC(50) values of 0.93 and 0.82 microM, respectively.
  63. ncbi New stigmastane sterols from Ajuga salicifolia
    Pinar Akbay
    Department of Applied BioSciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology ETH Zurich, CH 8057 Zurich, Switzerland
    J Nat Prod 66:461-5. 2003
    ..Compounds 1-4 are further representatives of the stigmastane type of sterols. Their cytotoxicity against KB (HeLa) and Jurkat T cancer cells was evaluated...
  64. ncbi Biologically active aspidofractinine, rhazinilam, akuammiline, and vincorine alkaloids from Kopsia
    G Subramaniam
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Nat Prod 70:1783-9. 2007
    ..17), and rhazinicine (18) showed appreciable cytotoxicity toward drug-sensitive as well as vincristine-resistant KB cells, while kopsiloscines A (2), B (3), and D (5) and aspidophylline A (11) were found to reverse drug-resistance in ..
  65. ncbi New cytotoxic 6,7-cis and 6,7-trans configured guaianolides from Warionia saharae
    Fatima Hilmi
    Department of Applied BioSciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology ETH Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Nat Prod 65:523-6. 2002
    ..Cytotoxicity testing against the KB cancer cell line revealed IC(50) values of 1.0 (1), 4.5 (2), 1.7 (3), 2.0 (4), 3.3 (5), and 5.5 (6) microg/mL...
  66. ncbi Cephalocyclidin A, a novel pentacyclic alkaloid from Cephalotaxus harringtonia var. nana
    Jun Ichi Kobayashi
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    J Org Chem 67:2283-6. 2002
    ..The relative and absolute stereochemistry of 1 was determined by a combination of NOESY correlations, X-ray crystallographic data, and the exciton chirality method...
  67. ncbi Daphnicyclidins J and K, unique polycyclic alkaloids from Daphniphyllum humile
    Hiroshi Morita
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    J Org Chem 67:2278-82. 2002
    ..The absolute stereochemistry of 1 was established by chemical correlation with a known-related alkaloid, daphnicyclidin D (3), through a modified Polonovski reaction...
  68. ncbi Sesquiterpene lactones from the roots of Ferula varia and their cytotoxic activity
    Kyoko Suzuki
    Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan
    J Nat Prod 70:1915-8. 2007
    ..The cytotoxicities of compounds 1, 3, 5, 8, and 11 against KB-C2 cells were enhanced in the presence of nontoxic concentrations of colchicine...
  69. ncbi Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum
    Eun Kyoung Seo
    Chemistry and Life Sciences Group, Research Triangle Institute, P O Box 12194, Research Triangle Park, North Carolina 27709, USA
    J Nat Prod 65:299-305. 2002
    ..In addition, two novel anthraquinobenzophenones, cratoxyarborequinones A (7) and B (8), and two known compounds, 2,4,6-trihydroxybenzophenone 4-O-geranyl ether and delta-tocotrienol, were obtained as inactive constituents...
  70. ncbi Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata
    Hongjie Zhang
    Program for Collaborative Research in Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, Illinois 60612, USA
    J Nat Prod 65:215-7. 2002
    ..26 (0.75), 0.20 (0.57), 0.90 (2.59), 0.90 (2.59), and 0.50 (1.44) microg/mL (microM), respectively. The structure of 1 was elucidated by spectroscopic means including 1D and 2D NMR techniques...
  71. ncbi Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris
    Nicholas H Oberlies
    Chemistry and Life Sciences, Research Triangle Institute, P O Box 12194, Research Triangle Park, North Carolina 27709 2194, USA
    J Nat Prod 65:95-9. 2002
    ..All three compounds displayed promising bioactivity, both in cytotoxicity assays against a panel of tumor cell lines and in antifungal assays via the growth inhibition of Aspergillus niger in a disk diffusion assay...
  72. ncbi Juncenolide A, a new briarane from the Taiwanese Gorgonian Junceella juncea
    Ya Ching Shen
    Institute of Marine Resources, National Sun Yat Sen University, 70 Lien Hai Road, Kaohsiung, Taiwan, Republic of China
    J Nat Prod 65:54-6. 2002
    ..The structure of 1 was determined on the basis of 2D NMR techniques, including COSY, HSQC, HMBC, and NOESY experiments, and was also confirmed by X-ray crystallographic analysis...
  73. ncbi Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452
    Hendrik Luesch
    Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
    J Nat Prod 65:16-20. 2002
    ..9 to 10.3 nM. It disrupts microtubules, but at a higher concentration than 2, correlating with the weaker in vitro cytotoxicity...
  74. ncbi Screening and discovery of novel MDR modifiers from naturally occurring bisbenzylisoquinoline alkaloids
    L W Fu
    Department of Pathology, Medical University of South Carolina, Charleston 29425, USA
    Anticancer Res 21:2273-80. 2001
    ..Another important feature is that the in vitro cytotoxic effect of these naturally occurring BBIs themselves on tumor cells was very low. Thus, these compounds may possess great promise in being developed into novel MDR modifiers...
  75. ncbi A cycloartane incorporating a fused tetrahydrofuran ring and a cytotoxic lactam from Monocarpia marginalis
    Siew Huah Lim
    Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
    J Nat Prod 71:1104-6. 2008
    ..The structures of these compounds were determined using NMR and MS analysis. Monomarginine (2) showed appreciable cytotoxicity toward human KB (both drug-sensitive and drug-resistant) and Jurkat cells...
  76. ncbi Cytotoxicity of Rhamnosylanthraquinones and Rhamnosylanthrones from Rhamnus nepalensis
    L P Mai
    Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France
    J Nat Prod 64:1162-8. 2001
    An extract of the fruits of Rhamnus nepalensis collected in Hoa Binh Province, Vietnam, was cytotoxic to KB cells. A bioassay-guided fractionation led to the isolation of a series of known anthraquinones and anthrones, one new ..
  77. ncbi Pervilleine A, a novel tropane alkaloid that reverses the multidrug-resistance phenotype
    Q Mi
    Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 South Wood St, Chicago, IL 60612, USA
    Cancer Res 61:4030-7. 2001
    ..Equimolar doses of verapamil were less effective. These data suggest that pervilleine A is an effective inhibitor of P-glycoprotein and should be further evaluated for clinical utility...
  78. ncbi First synthesis and anticancer activity of phosmidosine and its related compounds
    Tomohisa Moriguchi
    Faculty of Life Science, Tokyo Institute of Technology, Nagatsuta, Midoriku, Yokohama 226 8501, Japan
    J Org Chem 67:3290-300. 2002
    ..These results suggest that phosmidosine and its related compounds would be promising as a new type of anticancer agents having a wide range of inhibitory activities against tumor cells...
  79. ncbi Globulixanthones A and B, two new cytotoxic xanthones with isoprenoid groups from the root bark of Symphonia globulifera
    Augustin E Nkengfack
    Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P O Box 812 Yaounde, Cameroon
    J Nat Prod 65:734-6. 2002
    ..The structures of these compounds have been elucidated by spectroscopic means. They possess significant cytotoxicity in vitro against the KB cell line...
  80. ncbi Goniolactones A-F, six new styrylpyrone derivatives from the roots of Goniothalamus cheliensis
    Si Wang
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People s Republic of China
    J Nat Prod 65:835-41. 2002
    ..Goniolactone B (2) exhibited significant cytotoxicity against A2780, HCT-8, and KB cells with IC(50) values of 7.40, 4.43, and 7.23 microM, respectively.
  81. ncbi Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando
    Eun Kyoung Seo
    Chemistry and Life Sciences, Research Triangle Institute, PO Box 12194, Research Triangle Park, North Carolina 27709, USA
    Arch Pharm Res 26:124-7. 2003
    ..Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic...
  82. ncbi 9-epi-Viridiol, a novel cytotoxic furanosteroid from soil fungus Trichoderma virens
    Preecha Phuwapraisirisan
    Natural Product Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    Nat Prod Res 20:1321-5. 2006
    ..9-epi-Viridiol exhibited cytotoxicity towards HeLa and KB cells with IC50 values of 19 and 50 microg mL(-1), respectively.
  83. ncbi New cytotoxic furanosesterterpenes from an Okinawan marine sponge, Ircinia sp
    Hamad H Issa
    Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903 0213, Japan
    J Nat Prod 66:251-4. 2003
    ..and their structures elucidated by spectroscopic and chemical methods. The absolute configurations of two metabolites (1, 3) were established by chemical degradation. These compounds showed moderate cytotoxicity against KB cells.
  84. ncbi New alkaloids from Cephalotaxus fortunei
    Mamadou Bocar
    Laboratoire de Chimie des Substances Naturelles, ESA 8041, CNRS, Museum national d histoire naturelle, 63 Rue Buffon 75005 Paris, France
    J Nat Prod 66:152-4. 2003
    ..The structures were determined by spectral analysis including mass spectrometry and 2D NMR. Compounds 1, 2, 3, and 4 displayed cytotoxicity against nasopharynx KB cells with IC50 values of 30, 14, 31, and 15 micro g/mL, respectively.
  85. ncbi Lyngbyaloside B, a new glycoside macrolide from a Palauan marine cyanobacterium, Lyngbya sp
    Hendrik Luesch
    Department of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, USA
    J Nat Prod 65:1945-8. 2002
    ..The relative stereochemistry for the 12 stereocenters is proposed on the basis of proton-proton spin-coupling constants and ROESY data...
  86. ncbi Oxidation products of abietic acid and its methyl ester
    Sonja Prinz
    Department of Applied BioSciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology ETH Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Nat Prod 65:1530-4. 2002
    ..The cytotoxicity of several compounds against KB cells was evaluated, and weak activity was observed for 6, 7, and 8 with IC(50) values of 12.5, 4.5, and 5...
  87. ncbi Cytotoxic clerodane diterpenoids from fruits of Casearia grewiifolia
    Somdej Kanokmedhakul
    Department of Chemistry, Applied Taxonomic Research Center, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand
    J Nat Prod 70:1122-6. 2007
    ..The structures of 1-8 were established on the basis of 1D and 2D NMR spectroscopic data. Most of these compounds exhibited cytotoxicity against three cancer cell lines with IC50 values in the range 0.15-6.00 microg/mL...
  88. ncbi Two new subergane-based sesquiterpenes from a Taiwanese Gorgonian coral Subergorgia suberosa
    Guey Horng Wang
    Department of Marine Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 65:1033-6. 2002
    ..Subergorgiol (1) may be the biosynthetic precursor of 2-6. Compound 3 was found to exhibit moderate cytotoxicity against the growth of HeLa cancer cells...
  89. ncbi New cytotoxic cucurbitacins from the pericarps of Trichosanthes tricuspidata fruits
    Le Phuong Mai
    Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Nat Prod Lett 16:15-9. 2002
    An extract of the fruits of Trichosanthes tricuspidata collected in North Vietnam was found cytotoxic in KB cells. A bioassay-guided fractionation led to the isolation of a series of cucurbitacins of which two are new: tricuspidatin and 2-..
  90. ncbi [Synthesis and drug resistant reversal activities of taxane-like multi-drug resistant reversal agents]
    Meng Zhang
    Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China
    Yao Xue Xue Bao 38:424-9. 2003
    ..To design and synthesize a series of new taxoids with a 5-O-sidechain, and to test the multi-drug resistant reversal activity of these compound on KB/V200 cells which is 180 times more resistant to vincristine...
  91. ncbi Anti-angiogenic and anti-tumor activity of Bavachinin by targeting hypoxia-inducible factor-1α
    Manoj Nepal
    Department of Dental Pharmacology, School of Dentistry, and Brain Korea 21 Project, Chonbuk National University, Jeon Ju, Chonbuk561 756, Republic of Korea
    Eur J Pharmacol 691:28-37. 2012
    ..also inhibited tube formation in human umbilical vein endothelial cells (HUVECs) as well as in vitro migration of KB cells. In vivo studies showed that injecting Bavachinin thrice weekly for four weeks significantly reduced tumor volume ..
  92. ncbi A "click chemistry" approach to the efficient synthesis of multiple imaging probes derived from a single precursor
    Thomas L Mindt
    Department of Chemistry and Applied Biosciences, ETH Zurich, Switzerland
    Bioconjug Chem 20:1940-9. 2009
    ..high affinity toward the folic acid receptor (FR) and/or were specifically internalized into FR-overexpressing KB cells. In vivo experiments with nude mice showed that all probes (except the MRI probes which have not been tested yet) ..
  93. pmc Gyromagnetic imaging: dynamic optical contrast using gold nanostars with magnetic cores
    Qingshan Wei
    Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907 2084, USA
    J Am Chem Soc 131:9728-34. 2009
    ..The gyromagnetically active nanostars do not cause a loss in viability, and can even have a mild stimulatory effect on cell growth...
  94. ncbi Synthesis and cytotoxic evaluation of a series of resveratrol derivatives
    Ban Feng Ruan
    Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P R China
    Chem Biodivers 3:975-81. 2006
    ..On the basis of the experimental data obtained, structure-activity relationships are discussed...
  95. ncbi A novel peroxisome proliferator-activated receptor alpha/gamma agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells
    Yu Hsun Kao
    Graduate Institute of Life Sciences, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Anticancer Drugs 19:151-8. 2008
    ..of topo II in vitro, but did not produce detectable topo II-mediated DNA strand breaks in human oral cancer KB cells. Furthermore, BPR1H0101 could inhibit VP16-induced topo II-mediated DNA cleavage and ataxia-telangiectasia-..
  96. ncbi Antifolate pseudo-resistance due to elevated levels of thymidine and hypoxanthine in a commercial serum preparation
    Marcel Simon
    Department Molekulare Toxikologie G120, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    Anticancer Res 27:769-73. 2007
    ..Batch variability of sera used for cell culture is of considerable experimental concern. A novel fetal calf serum product, FCS Gold, was claimed to be the first defined fetal calf serum free of batch variation...
  97. pmc In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometry
    Wei He
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 104:11760-5. 2007
    ....
  98. ncbi The effect of laser therapy on the proliferation of oral KB carcinoma cells: an in vitro study
    Jurema Lisboa Freire de Castro
    Laser Center, School of Dentistry, Federal University of Bahia, Salvador, BA, Brazil
    Photomed Laser Surg 23:586-9. 2005
    ..The aim of this study was to assess the proliferative effect of carcinoma cells, strain KB, submitted to laser therapy with wavelengths of lambda685nm (31 mW; Ø; 0.38 cm(2), 4 J/cm(2)) or lambda830nm (34.5 mW; Ø; 0.38 cm(2), 4 J/cm(2))...
  99. ncbi Growth inhibition and chemosensitization of human carcinoma cells by human serum albumin-coated liposomal antisense oligodeoxyribonucleotide against bcl-2
    Wanlop Weecharangsan
    Department of Pharmaceutical Technology, Faculty of Pharmacy, Srinakharinwirot University, Nakhonnayok, Thailand
    Drug Deliv 19:292-7. 2012
    ..In the current study, cell growth inhibition and chemosensitization of KB cells were evaluated...
  100. ncbi Pterocarpans from the root bark of Aeschynomene fascicularis
    Edgar Caamal-Fuentes
    Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Calle 43 No 130, Col Chuburna de Hidalgo, Merida, Yucatan 97200, Mexico
    Nat Prod Commun 8:1421-2. 2013
    ..Both compounds were tested in vitro for their cytotoxic and antiproliferative activities against a panel of cancer cell lines. This is the first report on the presence of pterocarpans in the genus Aeschynomene...
  101. ncbi Antibacterial and cytotoxic activity of prenylated bicyclic acylphloroglucinol derivatives from Hypericum amblycalyx
    Karin Winkelmann
    Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology ETH Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Z Naturforsch C 58:527-32. 2003
    ..All compounds showed moderate cytotoxic activity against KB and Jurkat T cancer cells. Especially compounds 3 and 4 exhibited a strong antibacterial activity against different Gram-positive strains...

Research Grants13

  1. THE S. CEREVISIAE S PHASE CHECKPOINT
    Steven Reed; Fiscal Year: 2003
    ....
  2. Voice-preserved therapy of laryngeal papilloma in children
    Zhi Wang; Fiscal Year: 2009
    ..It would be safe and convenient enough for an out-patient treatment. ..
  3. The role of Cyclin E in growth control and tumorogenesis
    Steven Reed; Fiscal Year: 2008
    ..It is hoped that insights gained from understanding these fundamental mechanisms of oncogenesis will lead to new approaches to cancer prevention and therapy. ..
  4. Imaging Evaluation of Cancer Chemoprevention
    Zhi Wang; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  5. P. gingivalis lipid A species modulation of endothelial cell gene activation prog
    Richard Darveau; Fiscal Year: 2007
    ..gingivalis interactions with TLR4 or other novel LPS receptors. Furthermore, the microarray analysis results will be made public by deposition at the European Bioinformatics Institute Array Express database. [unreadable] [unreadable]..
  6. Laser Atraumatic Treatment of Ectasias on Vocal Cords
    Zhi Wang; Fiscal Year: 2006
    ..It would be safe and convenient enough for an out-patient treatment, without requiring a general anesthesia. [unreadable] [unreadable]..
  7. Voice-preserving Treatment of Larynegeal Papilloma
    Zhi Wang; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  8. Laser Assisted Celecoxib Treatment of Oral Leukoplakia
    Zhi Wang; Fiscal Year: 2006
    ..The same concept and approach also is available for skin or other pre-malignant lesion located on tissue surface. [unreadable] [unreadable]..
  9. Biofilm Chemoprevention of Head/Neck Skin Cancer
    Zhi Wang; Fiscal Year: 2005
    ..This is the first study to use polymer biofilm technique for NMSC chemoprevention on head/neck region. We believe that a successful study will greatly benefit patients. ..
  10. ASM Conf. on Beneficial Microbial Symbionts in Animals
    Richard Darveau; Fiscal Year: 2005
    ..It is an intellectually stimulating subject that attracts pioneering graduate students and post-doctoral fellows who will benefit from participation in a focused and dynamic conference; ..
  11. LBP/CD14 interactions with bacterial components
    Richard Darveau; Fiscal Year: 2005
    ..These studies will provide further insight into how the innate host defense system recognizes and responds to different bacteria, a key component of both oral health and disease. ..
  12. Oral Commensal Bacterial Modulation of the Periodontal Innate Host Response
    RICHARD PETERS DARVEAU; Fiscal Year: 2010
    ....
  13. Targeted Liposomal Doxorubicin Delivery to Leukemia
    Robert Lee; Fiscal Year: 2007
    ..abstract_text> ..