endothelial cells

Summary

Summary: Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.

Top Publications

  1. pmc Conversion of vascular endothelial cells into multipotent stem-like cells
    Damian Medici
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:1400-6. 2010
  2. doi Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting
    Lars Jakobsson
    Vascular Biology Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Nat Cell Biol 12:943-53. 2010
  3. pmc AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    Tracy T Batchelor
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cancer Cell 11:83-95. 2007
  4. ncbi Blood-brain barrier-specific properties of a human adult brain endothelial cell line
    B B Weksler
    Institut Cochin, CNRS UMR 8104 INSERM U567, Universite Rene Descartes, Paris, France
    FASEB J 19:1872-4. 2005
  5. ncbi Endothelial/pericyte interactions
    Annika Armulik
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Circ Res 97:512-23. 2005
  6. pmc HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    Rose Du
    Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cancer Cell 13:206-20. 2008
  7. ncbi Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms
    T Kinnaird
    Cardiovascular Research Institute, Washington, DC 20010, USA
    Circulation 109:1543-9. 2004
  8. ncbi Endothelial cell migration during angiogenesis
    Laurent Lamalice
    Le Centre de recherche en cancérologie, l Université Laval, L Hôtel Dieu de Québec, Quebec, Canada
    Circ Res 100:782-94. 2007
  9. doi Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death
    Anurag Kumar Gupta
    University Women s Hospital, Department of Biomedicine, Basel University Hospital, Basel, Switzerland
    FEBS Lett 584:3193-7. 2010
  10. ncbi Circulating endothelial progenitor cells and cardiovascular outcomes
    Nikos Werner
    Division of Cardiology, Angiology, and Intensive Care Medicine, Department of Internal Medicine, University of Saarland, Homburg Saar, Germany
    N Engl J Med 353:999-1007. 2005

Research Grants

  1. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
  2. Emilio B Gonzalez; Fiscal Year: 2014
  3. Stephen E McGowan; Fiscal Year: 2016
  4. JAMES RUSSELL SOWERS; Fiscal Year: 2015
  5. Terence S Dermody; Fiscal Year: 2015
  6. Junxuan Lu; Fiscal Year: 2014
  7. Mitzi Nagarkatti; Fiscal Year: 2015
  8. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
  9. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2012
  10. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2012

Detail Information

Publications453 found, 100 shown here

  1. pmc Conversion of vascular endothelial cells into multipotent stem-like cells
    Damian Medici
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:1400-6. 2010
    ..Here we show that vascular endothelial cells can transform into multipotent stem-like cells by an activin-like kinase-2 (ALK2) receptor-dependent ..
  2. doi Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting
    Lars Jakobsson
    Vascular Biology Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Nat Cell Biol 12:943-53. 2010
    Sprouting angiogenesis requires the coordinated behaviour of endothelial cells, regulated by Notch and vascular endothelial growth factor receptor (VEGFR) signalling...
  3. pmc AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    Tracy T Batchelor
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cancer Cell 11:83-95. 2007
    ..Basic FGF, SDF1alpha, and viable circulating endothelial cells (CECs) increased when tumors escaped treatment, and circulating progenitor cells (CPCs) increased when ..
  4. ncbi Blood-brain barrier-specific properties of a human adult brain endothelial cell line
    B B Weksler
    Institut Cochin, CNRS UMR 8104 INSERM U567, Universite Rene Descartes, Paris, France
    FASEB J 19:1872-4. 2005
    ..To accomplish this, normal human brain endothelial cells were transduced by lentiviral vectors incorporating human telomerase or SV40 T antigen...
  5. ncbi Endothelial/pericyte interactions
    Annika Armulik
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Circ Res 97:512-23. 2005
    Interactions between endothelial cells and mural cells (pericytes and vascular smooth muscle cells) in the blood vessel wall have recently come into focus as central processes in the regulation of vascular formation, stabilization, ..
  6. pmc HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    Rose Du
    Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cancer Cell 13:206-20. 2008
    ..VEGF also directly regulates tumor cell invasiveness. When VEGF activity is impaired, tumor cells invade deep into the brain in the perivascular compartment...
  7. ncbi Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms
    T Kinnaird
    Cardiovascular Research Institute, Washington, DC 20010, USA
    Circulation 109:1543-9. 2004
    ..Bone marrow cell therapy is reported to contribute to collateral formation through cell incorporation into new or remodeling vessels. However, the possible role of a paracrine contribution to this effect is less well characterized...
  8. ncbi Endothelial cell migration during angiogenesis
    Laurent Lamalice
    Le Centre de recherche en cancérologie, l Université Laval, L Hôtel Dieu de Québec, Quebec, Canada
    Circ Res 100:782-94. 2007
    ..Then, it follows a series of events in which the endothelial cells extend, contract, and throw their rear toward the front and progress forward...
  9. doi Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death
    Anurag Kumar Gupta
    University Women s Hospital, Department of Biomedicine, Basel University Hospital, Basel, Switzerland
    FEBS Lett 584:3193-7. 2010
    Neutrophil interaction with activated endothelial cells (EC) is required for transmigration. We examined consequences of this interaction on NETosis...
  10. ncbi Circulating endothelial progenitor cells and cardiovascular outcomes
    Nikos Werner
    Division of Cardiology, Angiology, and Intensive Care Medicine, Department of Internal Medicine, University of Saarland, Homburg Saar, Germany
    N Engl J Med 353:999-1007. 2005
    ..The number and function of endothelial progenitor cells correlate inversely with cardiovascular risk factors, but the prognostic value associated with circulating endothelial progenitor cells has not been defined...
  11. ncbi Astrocyte-endothelial interactions at the blood-brain barrier
    N Joan Abbott
    Wolfson Centre for Age Related Diseases, King s College London, UK
    Nat Rev Neurosci 7:41-53. 2006
    The blood-brain barrier, which is formed by the endothelial cells that line cerebral microvessels, has an important role in maintaining a precisely regulated microenvironment for reliable neuronal signalling...
  12. doi Lymphangiogenesis: Molecular mechanisms and future promise
    Tuomas Tammela
    Molecular Cancer Biology Laboratory and Haartman Institute, University of Helsinki, Finland
    Cell 140:460-76. 2010
    ..The recent explosion of knowledge on the molecular mechanisms governing lymphangiogenesis provides new possibilities to treat these diseases...
  13. doi Basic and therapeutic aspects of angiogenesis
    Michael Potente
    Vascular Epigenetics Group, Institute for Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University, D 60590 Frankfurt, Germany
    Cell 146:873-87. 2011
    ..Recent insights establish how endothelial cells communicate with each other and with their environment to form a branched vascular network...
  14. ncbi ICAM-1 signaling in endothelial cells
    Charlotte Lawson
    Veterinary Basic Sciences, Royal Veterinary College, London, UK
    Pharmacol Rep 61:22-32. 2009
    ..ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines...
  15. pmc Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction
    Alessandro Fantin
    UCL Institute of Ophthalmology, University College London, London, United Kingdom
    Blood 116:829-40. 2010
    ..Our findings suggest that tissue macrophages are a target for antiangiogenic therapies, but that they could equally well be exploited to stimulate tissue vascularization in ischemic disease...
  16. ncbi VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells
    Myriam Grunewald
    Department of Molecular Biology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Cell 124:175-89. 2006
    ..RBCCs enhance in situ proliferation of endothelial cells via secreting proangiogenic activities distinct from locally induced activities...
  17. pmc The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis
    Shusheng Wang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Dev Cell 15:261-71. 2008
    b>Endothelial cells play essential roles in maintenance of vascular integrity, angiogenesis, and wound repair. We show that an endothelial cell-restricted microRNA (miR-126) mediates developmental angiogenesis in vivo...
  18. pmc Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    Johan Skog
    Department of Neurology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Nat Cell Biol 10:1470-6. 2008
    ..These microvesicles are taken up by normal host cells, such as brain microvascular endothelial cells. By incorporating an mRNA for a reporter protein into these microvesicles, we demonstrate that messages ..
  19. ncbi Endothelial progenitor cells: characterization and role in vascular biology
    Carmen Urbich
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circ Res 95:343-53. 2004
    ..cells, and mesenchymal cells) and non-bone marrow-derived cells, which also can give rise to endothelial cells. The characterization of the different progenitor cell populations and their functional properties are ..
  20. ncbi Endothelial cells and VEGF in vascular development
    Leigh Coultas
    The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada
    Nature 438:937-45. 2005
    ..New insights into non-vascular roles of vascular endothelial growth factor and the requirement for endothelial cells in adult organs and stem-cell niches highlight possible side effects of anti-angiogenic therapy and the need ..
  21. pmc Endothelial progenitor cells: identity defined?
    Frank Timmermans
    Department of Clinical Chemistry, Microbiology and Immunology, University of Ghent, University Hospital Ghent, De Pintelaan, Ghent, Belgium
    J Cell Mol Med 13:87-102. 2009
    ..cells were suggested to home to sites of neovascularization and neoendothelialization and differentiate into endothelial cells (ECs) in situ, a process referred to as postnatal vasculogenesis...
  22. ncbi A central role for inflammation in the pathogenesis of diabetic retinopathy
    Antonia M Joussen
    Department of Vitreoretinal Surgery and Angiogenesis Laboratory, Center of Ophthalmology, University of Cologne, Koln, Germany
    FASEB J 18:1450-2. 2004
    ..This condition is associated with fewer damaged endothelial cells and lesser vascular leakage...
  23. ncbi Mechanisms of uremic erythrocyte-induced adhesion of human monocytes to cultured endothelial cells
    Assunta Pandolfi
    Department of Biomorphology, University G D Annunzio, Aging Research Center, Ce S I, G d Annunzio University Foundation, Chieti Pescara, Italy
    J Cell Physiol 213:699-709. 2007
    ..Thus, intervention targeting ESRD-RBC increased adhesion to endothelium and/or MAPK and Akt/eNOS pathways may have the potential to prevent vascular lesions under uremic conditions...
  24. ncbi Mitochondrial reactive oxygen species-mediated signaling in endothelial cells
    David X Zhang
    Department of Internal Medicine and Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 292:H2023-31. 2007
    ..Several enzymatic systems contribute to ROS production in vascular endothelial cells, including NA(D)PH oxidase, xanthine oxidase, uncoupled endothelial nitric oxide synthase, and the ..
  25. doi The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence
    Jorge Ivan Alvarez
    Neuroimmunology Unit, Center of Excellence in Neuromics, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Science 334:1727-31. 2011
    The blood-brain barrier (BBB) is composed of tightly bound endothelial cells (ECs) and perivascular astrocytes that regulate central nervous system (CNS) homeostasis...
  26. ncbi Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells
    Qin Shen
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Science 304:1338-40. 2004
    ..We show that endothelial cells but not vascular smooth muscle cells release soluble factors that stimulate the self-renewal of neural stem ..
  27. ncbi Phenotypic heterogeneity of the endothelium: II. Representative vascular beds
    William C Aird
    Division of Molecular and Vascular Medicine, Department of Medicine, and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    Circ Res 100:174-90. 2007
    b>Endothelial cells, which form the inner cellular lining of blood vessels and lymphatics, display remarkable heterogeneity in structure and function...
  28. doi Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages
    Lei Bu
    Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Nature 460:113-7. 2009
    ..These results lay the foundation for the generation of human model systems for cardiovascular disease and novel approaches for human regenerative cardiovascular medicine...
  29. doi Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs
    Eduard Hergenreider
    Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Hospital, 60590 Frankfurt, Germany
    Nat Cell Biol 14:249-56. 2012
    ..in many pathogenic and physiological processes, we investigated the regulation of miRNAs by KLF2 in endothelial cells. KLF2 binds to the promoter and induces a significant upregulation of the miR-143/145 cluster...
  30. ncbi Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    J Cereb Blood Flow Metab 27:697-709. 2007
    ..Disrupted TJPs previously seen in endothelial cells appeared in the surrounding astrocytes...
  31. pmc The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?
    Christine Moussion
    CNRS, Institute of Pharmacology and Structural Biology, Toulouse, France
    PLoS ONE 3:e3331. 2008
    ..Although the activity of recombinant IL-33 has been well characterized, little is known yet about the expression pattern of endogenous IL-33 in vivo...
  32. pmc Haematopoietic stem cells derive directly from aortic endothelium during development
    Julien Y Bertrand
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0380, USA
    Nature 464:108-11. 2010
    ..Recent reports have suggested that murine HSCs derive from haemogenic endothelial cells (ECs) lining the aortic floor...
  33. pmc Impact of glycemic control on circulating endothelial progenitor cells and arterial stiffness in patients with type 2 diabetes mellitus
    Wen Sheng Yue
    Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China
    Cardiovasc Diabetol 10:113. 2011
    ..Levels of circulating endothelial progenitor cells (EPCs) are also reduced in hyperglycemic states. However, the relationships between glycemic control, levels of EPCs and arterial stiffness are unknown...
  34. pmc Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells
    Katrin J Svensson
    Department of Clinical Sciences, Section of Oncology, Lund University, SE 221 85 Lund, Sweden
    Proc Natl Acad Sci U S A 108:13147-52. 2011
    ..The identified pathway may constitute an interesting target for the development of additional strategies to treat aggressive brain tumors...
  35. doi Pericytes regulate the blood-brain barrier
    Annika Armulik
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institute, Scheeles vag 2, SE 171 77 Stockholm, Sweden
    Nature 468:557-61. 2010
    ..pericytes function at the BBB in at least two ways: by regulating BBB-specific gene expression patterns in endothelial cells, and by inducing polarization of astrocyte end-feet surrounding CNS blood vessels...
  36. pmc Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals
    Mervin C Yoder
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 109:1801-9. 2007
    ..Thus, these studies establish that CFU-ECs are not EPCs and the role of these cells in angiogenesis must be re-examined prior to further clinical trials, whereas ECFCs may serve as a potential therapy for vascular regeneration...
  37. ncbi Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms
    Kurt R Stenmark
    Department of Pediatrics, Developmental Lung Biology Laboratory, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Circ Res 99:675-91. 2006
    ..This review provides perspectives on each of the aforementioned areas...
  38. pmc Cellular and molecular basis of pulmonary arterial hypertension
    Nicholas W Morrell
    Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    J Am Coll Cardiol 54:S20-31. 2009
    ....
  39. ncbi Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms
    William C Aird
    Division of Molecular and Vascular Medicine, Department of Medicine, and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    Circ Res 100:158-73. 2007
    b>Endothelial cells, which form the inner cellular lining of blood vessels and lymphatics, display remarkable heterogeneity in structure and function...
  40. ncbi Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
    Elisabeth M Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 13:952-61. 2007
    ..Here we show that cardiac fibrosis is associated with the emergence of fibroblasts originating from endothelial cells, suggesting an endothelial-mesenchymal transition (EndMT) similar to events that occur during formation of ..
  41. pmc Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives
    Jeng Jiann Chiu
    Division of Medical Engineering Research, National Health Research Institutes, Taiwan
    Physiol Rev 91:327-87. 2011
    Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC functions and vascular biology/pathobiology in health and disease. The flow patterns and hemodynamic forces are not uniform in the vascular system...
  42. ncbi Blood-brain barrier: structural components and function under physiologic and pathologic conditions
    Yuri Persidsky
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neuroimmune Pharmacol 1:223-36. 2006
    The blood-brain barrier (BBB) is the specialized system of brain microvascular endothelial cells (BMVEC) that shields the brain from toxic substances in the blood, supplies brain tissues with nutrients, and filters harmful compounds from ..
  43. doi A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes
    Shinsuke Nakagawa
    Department of Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Japan
    Neurochem Int 54:253-63. 2009
    Blood-brain barrier (BBB) characteristics are induced and maintained by cross-talk between brain microvessel endothelial cells and neighbouring elements of the neurovascular unit...
  44. doi Spatial coordination between cell and nuclear shape within micropatterned endothelial cells
    Marie Versaevel
    Mechanobiology and Soft Matter Group, Laboratoire Interfaces et Fluides Complexes, CIRMAP, Faculte des Sciences, Universite de Mons, 20, Place du Parc, B 7000 Mons, Belgium
    Nat Commun 3:671. 2012
    ..On the basis of these findings, we propose a simple mechanical model that quantitatively accounts for our experimental data and provides a conceptual framework for the mechanistic coordination between cell and nuclear shape...
  45. pmc Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells
    K Yamamoto
    Department of Vascular Biology, Graduate School of Dental Medicine, N13 W7, University of Hokkaido, Sapporo, Hokkaido 060 8586, Japan
    Br J Cancer 106:1214-23. 2012
    We isolated tumour endothelial cells (TECs), demonstrated their abnormalities, compared gene expression profiles of TECs and normal endothelial cells (NECs) by microarray analysis and identified several genes upregulated in TECs...
  46. pmc miR-126 regulates angiogenic signaling and vascular integrity
    Jason E Fish
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Dev Cell 15:272-84. 2008
    ..Here, we identified microRNAs that were enriched in endothelial cells derived from mouse embryonic stem (ES) cells and in developing mouse embryos...
  47. ncbi Adiponectin stimulates production of nitric oxide in vascular endothelial cells
    Hui Chen
    Diabetes Unit, Laboratory of Clinical Investigation, NCCAM, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:45021-6. 2003
    ..Bovine aortic endothelial cells in primary culture loaded with the NO-specific fluorescent dye 4,5-diaminofluorescein diacetate (DAF-2 DA) ..
  48. ncbi A mechanosensory complex that mediates the endothelial cell response to fluid shear stress
    Eleni Tzima
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 437:426-31. 2005
    ..Therefore, this mechanosensing pathway is required for the earliest-known events in atherogenesis...
  49. pmc SIRT1 controls endothelial angiogenic functions during vascular growth
    Michael Potente
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, 60590 Frankfurt, Germany
    Genes Dev 21:2644-58. 2007
    ..highly expressed in the vasculature during blood vessel growth, where it controls the angiogenic activity of endothelial cells. Loss of SIRT1 function blocks sprouting angiogenesis and branching morphogenesis of endothelial cells with ..
  50. doi Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis
    Dingcheng Gao
    Cancer Genome Research Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 319:195-8. 2008
    ..These findings establish the role of EPCs in metastatic progression in preclinical models and suggest that selective targeting of EPCs may merit investigation as a therapy for cancer patients with lung metastases...
  51. doi Blood stem cells emerge from aortic endothelium by a novel type of cell transition
    Karima Kissa
    Institut Pasteur, Unité Macrophages et Développement de l Immunité and CNRS URA2578, 25 rue du Dr Roux, F 75724 Paris Cedex 15, France
    Nature 464:112-5. 2010
    ..embryonic development is still highly debated, especially their possible lineage relationship to vascular endothelial cells. The first anatomical site from which cells with long-term HSC potential have been isolated is the aorta-..
  52. ncbi Mesenchymal stem cells can be differentiated into endothelial cells in vitro
    Joachim Oswald
    Institute of Polymer Research Dresden and The Max Bergmann Center of Biomaterials Dresden, Dresden, Germany
    Stem Cells 22:377-84. 2004
    ..show the differentiation of expanded adult human MSCs into cells with phenotypic and functional features of endothelial cells. These predifferentiated cells provide new options for engineering of artificial tissues based on autologous ..
  53. ncbi Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair
    Caroline Schmidt-Lucke
    Molecular Cardiology, Department of Medicine III, J W Goethe University, Frankfurt, Germany
    Circulation 111:2981-7. 2005
    ..Circulating EPCs may thus provide an endogenous repair mechanism to counteract ongoing risk factor-induced endothelial injury and to replace dysfunctional endothelium...
  54. ncbi Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling
    Marie Jose Goumans
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Mol Cell 12:817-28. 2003
    ..Here, we report that ALK5 is important for TGFbeta/ALK1 signaling; endothelial cells lacking ALK5 are deficient in TGFbeta/ALK1-induced responses...
  55. ncbi Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis
    Raghu Adya
    Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Cardiovasc Res 78:356-65. 2008
    ..We therefore investigated the effect of visfatin on vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP-2, MMP-9) production and the potential signalling cascades...
  56. doi The blood-brain barrier in brain homeostasis and neurological diseases
    Nicolas Weiss
    Institut Cochin, Universite Paris Descartes, Paris, France
    Biochim Biophys Acta 1788:842-57. 2009
    Brain endothelial cells are unique among endothelial cells in that they express apical junctional complexes, including tight junctions, which quite resemble epithelial tight junctions both structurally and functionally...
  57. pmc Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
    Massimiliano Mazzone
    Vesalius Research Center, VIB Vlaams Instituut voor Biotechnologie, Leuven, Belgium
    Cell 136:839-51. 2009
    ..Thus, decreased activity of an oxygen sensor in hypoxic conditions prompts endothelial cells to readjust their shape and phenotype to restore oxygen supply...
  58. pmc MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis
    Stefania Nicoli
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 464:1196-200. 2010
    ..Subsequently, endothelial cells must incorporate the mechanosensory stimulus of blood flow with these early signals to shape the embryonic ..
  59. pmc Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis
    Goutam Ghosh
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Clin Invest 120:4141-54. 2010
    ..These results suggest that miR-322/424 plays an important physiological role in post-ischemic vascular remodeling and angiogenesis...
  60. ncbi Soluble endoglin contributes to the pathogenesis of preeclampsia
    Shivalingappa Venkatesha
    Center for Vascular Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Med 12:642-9. 2006
    ..Our results suggest that sEng may act in concert with sFlt1 to induce severe preeclampsia...
  61. ncbi VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin
    Julie Gavard
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD 20892 4340, USA
    Nat Cell Biol 8:1223-34. 2006
    ....
  62. ncbi Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization
    George E Davis
    Department of Pathology, Texas A and M University System Health Science Center, College Station, USA
    Circ Res 97:1093-107. 2005
    ..In concert with supporting cells, endothelial cells (ECs) assemble a laminin-rich basement membrane matrix that provides structural and organizational stability...
  63. ncbi Oxidative stress and increased eNOS and NADPH oxidase expression in mouse microvessel endothelial cells
    Hong Ding
    School of Medical Sciences, RMIT University, Bundoora West Campus, Bundoora, Victoria, Australia
    J Cell Physiol 212:682-9. 2007
    ..Oxidative stress was assessed in cell cultures of mouse microvessel endothelial cells (MMECs) by fluorescence labelling with dihydroethidium, lucigenin-enhanced chemiluminescence and determining ..
  64. pmc Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation
    Jarish N Cohen
    Department of Microbiology and Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Exp Med 207:681-8. 2010
    ..We demonstrate that LN-resident lymphatic endothelial cells express multiple peripheral tissue antigens (PTAs) independent of the autoimmune regulator (Aire)...
  65. pmc Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing
    Liwen Chen
    Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 3:e1886. 2008
    ..BM-MSC-conditioned medium significantly enhanced migration of macrophages, keratinocytes and endothelial cells and proliferation of keratinocytes and endothelial cells compared to fibroblast-conditioned medium...
  66. doi Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
    Yingdi Wang
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Nature 465:483-6. 2010
    ..as vascular endothelial growth factor (VEGF) family growth factors, the resulting signalling processes in endothelial cells are only partly understood...
  67. ncbi Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells
    Carmen Urbich
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Mol Cell Cardiol 39:733-42. 2005
    ..the expression profile of cytokines in human peripheral blood-derived EPC as opposed to human umbilical vein endothelial cells (HUVEC), human microvascular endothelial cells (HMVEC), and CD14(+) monocytes by microarray technology...
  68. pmc Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR
    Khalid Al-Nedawi
    Montreal Children s Hospital Research Institute, McGill University, Montreal, QC, Canada H3Z 2Z3
    Proc Natl Acad Sci U S A 106:3794-9. 2009
    ..MVs produced by human cancer cells harboring activated EGFR (A431, A549, DLD-1) can be taken up by cultured endothelial cells, in which they elicit EGFR-dependent responses, including activation of MAPK and Akt pathways...
  69. doi Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
    Lucia Ricci-Vitiani
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy
    Nature 468:824-8. 2010
    ..Normal neural stem cells are able to differentiate into functional endothelial cells. The connection between neural stem cells and the endothelial compartment seems to be critical in ..
  70. pmc Inhibition of autophagy rescues palmitic acid-induced necroptosis of endothelial cells
    Muhammad Jadoon Khan
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, 8010 Graz, Austria
    J Biol Chem 287:21110-20. 2012
    ..Moreover, siRNA-mediated knockdown of CYLD significantly antagonized PA-induced necrosis of endothelial cells. In contrast, inhibition and knockdown of receptor interacting protein kinase 1 (RIPK1) had no effect on PA-..
  71. pmc Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells
    Jason M Butler
    Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Cell Stem Cell 6:251-64. 2010
    Bone marrow endothelial cells (ECs) are essential for reconstitution of hematopoiesis, but their role in self-renewal of long-term hematopoietic stem cells (LT-HSCs) is unknown...
  72. ncbi Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA
    Maria Chiara Deregibus
    Department of Internal Medicine, Research Center for Experimental Medicine CeRMS and Center for Molecular Biotechnology, Torino, Italy
    Blood 110:2440-8. 2007
    ..We found that EPC-derived MVs were incorporated in endothelial cells by interaction with alpha4 and beta1 integrins expressed on the MV surface...
  73. pmc Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use
    Gian Paolo Fadini
    Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, University of Frankfurt, Theodor Stern Kai 7, Frankfurt, Germany
    Circ Res 110:624-37. 2012
    ..We also delineate new research avenues to move forward our knowledge on EPC biology...
  74. pmc Fate tracing reveals the endothelial origin of hematopoietic stem cells
    Ann C Zovein
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Cell Stem Cell 3:625-36. 2008
    ..Moreover, AGM mesenchyme, as selectively traced via a myocardin Cre line, is incapable of hematopoiesis. Our genetic tracing strategy therefore reveals an endothelial origin of HSCs...
  75. pmc Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter
    Michael J Chen
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Nature 457:887-91. 2009
    ..It is thought that HSCs emerge from vascular endothelial cells through the formation of intra-arterial clusters and that Runx1 functions during the transition from '..
  76. doi The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis
    Rui Benedito
    Cancer Research UK London Research Institute, Vascular Development Laboratory, London, UK
    Cell 137:1124-35. 2009
    ....
  77. doi Advanced glycation endproducts alter functions and promote apoptosis in endothelial progenitor cells through receptor for advanced glycation endproducts mediate overpression of cell oxidant stress
    Jianfei Chen
    Department of Cardiology, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, People s Republic of China
    Mol Cell Biochem 335:137-46. 2010
    ....
  78. pmc Disruptions of occludin and claudin-5 in brain endothelial cells in vitro and in brains of mice with acute liver failure
    Feng Chen
    Department of Transplantation, Mayo Clinic, Jacksonville, FL 32224, USA
    Hepatology 50:1914-23. 2009
    ..We transfected murine brain endothelial cells (ECs) with MMP-9 complementary DNA (cDNA) using pc DNA3.1 (+)/Myc-His A expression vector...
  79. ncbi The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation
    Ganka Nikolova
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Dev Cell 10:397-405. 2006
    ..Instead, by using VEGF-A, they attract endothelial cells, which form capillaries with a vascular basement membrane next to the beta cells...
  80. pmc Plasmodium falciparum-infected erythrocytes induce NF-kappaB regulated inflammatory pathways in human cerebral endothelium
    Abhai K Tripathi
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Blood 114:4243-52. 2009
    ..The inflammatory pathways were validated by direct measurement of proteins in brain endothelial supernatants. This study delineates the strong inflammatory component of human brain endothelium contributing to cerebral malaria...
  81. ncbi Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology
    Máiria A Deli
    Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research Centre of the Hungarian Academy of Sciences, Temesvari korut 62, H 6726 Szeged, Hungary
    Cell Mol Neurobiol 25:59-127. 2005
    ..2) Results from primary cultures of cerebral microvascular endothelial cells or immortalized cell lines from bovine, human, porcine, and rodent origin are presented...
  82. doi Angiogenesis: a team effort coordinated by notch
    L K Phng
    London Research Institute, Cancer Research UK, United Kingdom
    Dev Cell 16:196-208. 2009
    ..This review focuses on how endothelial cell-cell communication via the Notch pathway contributes to this signal integration and is essential for functional vessel patterning...
  83. doi The endothelial cell tube formation assay on basement membrane turns 20: state of the science and the art
    Irina Arnaoutova
    Trevigen Inc, Gaithersburg, MD, USA
    Angiogenesis 12:267-74. 2009
    It has been more than 20 years since it was first demonstrated that endothelial cells will rapidly form capillary-like structures in vitro when plated on top of a reconstituted basement membrane extracellular matrix (BME, Matrigel, EHS ..
  84. pmc Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue disease
    Raphaël M Zellweger
    La Jolla Institute for Allergy and Immunology, CA 92037, USA
    Cell Host Microbe 7:128-39. 2010
    ..Antibodies promote massive infection of liver sinusoidal endothelial cells (LSECs), resulting in increased systemic levels of virus...
  85. ncbi Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
    Dominador J Manalo
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Blood 105:659-69. 2005
    ..transcription of genes encoding angiogenic growth factors, which are secreted by hypoxic cells and stimulate endothelial cells, leading to angiogenesis...
  86. ncbi Evolving functions of endothelial cells in inflammation
    Jordan S Pober
    Interdepartmental Program in Vascular Biology and Therapeutics, Amistad Research Building, Yale University School of Medicine, 10 Amistad Street, New Haven, Connecticut 06509, USA
    Nat Rev Immunol 7:803-15. 2007
    Inflammation is usually analysed from the perspective of tissue-infiltrating leukocytes. Microvascular endothelial cells at a site of inflammation are both active participants in and regulators of inflammatory processes...
  87. pmc Cells respond to mechanical stress by rapid disassembly of caveolae
    Bidisha Sinha
    Université P et M Curie CNRS UMR, Paris, France
    Cell 144:402-13. 2011
    ..Our findings support a new role for caveolae as a physiological membrane reservoir that quickly accommodates sudden and acute mechanical stresses...
  88. pmc Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection
    John R Teijaro
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 146:980-91. 2011
    ..Whereas S1P(1) receptor is expressed on endothelial cells and lymphocytes within lung tissue, S1P(1) agonism suppresses cytokines and innate immune cell recruitment ..
  89. pmc Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposal
    Leo M Carlin
    Centre for Molecular and Cellular Biology of Inflammation, King s College London, London SE1 1UL, UK
    Cell 153:362-75. 2013
    ..Then, monocytes recruit neutrophils in a TLR7-dependent manner to mediate focal necrosis of endothelial cells, whereas the monocytes remove cellular debris...
  90. doi MiR-146a enhances angiogenic activity of endothelial cells in hepatocellular carcinoma by promoting PDGFRA expression
    Kai Zhu
    Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Carcinogenesis 34:2071-9. 2013
    b>Endothelial cells (ECs) are critical for angiogenesis, and microRNAs play important roles in this process...
  91. ncbi SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
    ..Many HSCs were associated with sinusoidal endothelium in spleen and bone marrow, though some HSCs were associated with endosteum. HSCs thus occupy multiple niches, including sinusoidal endothelium in diverse tissues...
  92. doi Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
    Harald C Ott
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Med 14:213-21. 2008
    ..To mimic cardiac cell composition, we reseeded these constructs with cardiac or endothelial cells. To establish function, we maintained eight constructs for up to 28 d by coronary perfusion in a bioreactor ..
  93. doi Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
    Tuomas Tammela
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 Haartmaninkatu 8, 00014 Helsinki, Finland
    Nature 454:656-60. 2008
    ..VEGFs) stimulate angiogenesis and lymphangiogenesis by activating VEGF receptor (VEGFR) tyrosine kinases in endothelial cells. VEGFR-3 (also known as FLT-4) is present in all endothelia during development, and in the adult it becomes ..
  94. doi MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1
    Rossella Menghini
    Department of Internal Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Circulation 120:1524-32. 2009
    ..Through a microarray approach, we have identified a microRNA (miR-217) that is progressively expressed in endothelial cells with aging...
  95. pmc Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 279:1304-9. 2004
    ..These data indicate that adiponectin can function to stimulate the new blood vessel growth by promoting cross-talk between AMP-activated protein kinase and Akt signaling within endothelial cells.
  96. ncbi Cytokine-induced mobilization of circulating endothelial progenitor cells enhances repair of injured arteries
    Deling Kong
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 110:2039-46. 2004
    ....
  97. ncbi Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia
    Shakil Ahmad
    Department of Reproductive and Vascular Biology, The Medical School, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TG, UK
    Circ Res 95:884-91. 2004
    ..001). In contrast, endothelial cells treated with preeclamptic CM showed substantially reduced angiogenesis compared with normal CM (P<0...
  98. ncbi Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes
    Thomas Thum
    Universitatsklinikum, Medizinische Klinik I, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Diabetes 56:666-74. 2007
    ..Subsequent reduction of EPC levels and impairment of EPC function likely contributes to the pathogenesis of vascular disease in diabetes...
  99. ncbi Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells
    Yajaira Suarez
    Department of Pathology, Yale University School of Medicine, New Haven, Conn 06536, USA
    Circ Res 100:1164-73. 2007
    ..To assess the role of Dicer and consequently the importance of miRNAs in the biology and functions of human endothelial cells (EC) during angiogenesis, we globally reduced miRNAs in ECs by specific silencing Dicer using siRNA and ..
  100. pmc P58(IPK) inhibition of endoplasmic reticulum stress in human retinal capillary endothelial cells in vitro
    Bin Li
    Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, People s Republic of China
    Mol Vis 14:1122-8. 2008
    ..factor 2alpha (eIF2alpha), inhibits endoplasmic reticulum (ER) stress and leads to downregulated expression of vascular endothelial growth factor (VEGF) and decreased apoptosis in human retinal capillary endothelial cells (HRCECs).
  101. pmc NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1
    Hua Liu
    Vascular Biology Center and Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta, GA 30912, USA
    Circ Res 104:466-75. 2009
    b>Endothelial cells and mural cells (smooth muscle cells, pericytes, or fibroblasts) are known to communicate with one another...

Research Grants84

  1. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..OA), the synovium of PsA is rich in NGF;major source of NGF is FLS;TrkA is upregulated in FLS, endothelial cells and activated T cells;NGF regulates both activation and survival of CD4+/CD8+ T cells...
  2. Emilio B Gonzalez; Fiscal Year: 2014
    ..APL Abs antibodies recognize domain I (DI) of 22glycoprotein I (22GPI). 22GPI binds to target cells [i.e.: endothelial cells (EC), platelets, monocytes] through domain V and trigger an intracellular signaling and a pro-coagulant and ..
  3. Stephen E McGowan; Fiscal Year: 2016
    ..Hypothesis: Formation and expansion of the alveolar capillary network requires cooperation among endothelial cells, pericytes, and lung fibroblasts (LF)...
  4. JAMES RUSSELL SOWERS; Fiscal Year: 2015
    ..1, we will examine the relationship between ANG II and S6K1 activation and INS signaling in primary cultured endothelial cells, vascular smooth muscle cells and cardiomyocytes...
  5. Terence S Dermody; Fiscal Year: 2015
    ..In Specific Aim 1, mechanisms by which reovirus binding to JAM-A promotes infection of endothelial cells and hematogenous dissemination will be determined...
  6. Junxuan Lu; Fiscal Year: 2014
    ..for PGG to inhibit G1 progression and validate G1- and S- arrest mechanisms in mitogen-activated vascular endothelial cells as one mechanism of anti-angiogenesis action of PGG. Aim 3...
  7. Mitzi Nagarkatti; Fiscal Year: 2015
    ..that CD44 isoforms such as CD44v6/v7 play a critical role in the interaction between activated T cells and endothelial cells (ECs) at sites of inflammation leading to EC injury...
  8. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..TLR4 activation with a potent TLR4 inhibitor, that appears to have some inhibitory effects on TLR2 in endothelial cells, through collaboration of a university-based expert in cerebral IRI, and X-In8, a new biotechnology company ..
  9. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2012
    ..of NADPH oxidase (NOX) enzyme isoforms that produce superoxide and increased eNOS expression in vascular endothelial cells and syncytiotrophoblast...
  10. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2012
    ..begun to characterize a new heme-containing peroxidase that is present in heart, vascular smooth muscle and endothelial cells. This Vascular PerOxidase, termed VPO, is highly homologous to MPO, but also contains multiple domains that ..
  11. Thalachallour Mohanakumar; Fiscal Year: 2015
    ..that BOS is an immunologically mediated process resulting in injury to the pulmonary epithelial and/or the endothelial cells. Recently, we have obtained evidence for an obligatory role for immune responses to lung associated self-..
  12. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
    ..of eNOS with the mitochondrial outer membrane protein, porin in normal fetal lamb pulmonary artery endothelial cells (PAEC)...
  13. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    ..DVs infect peripheral human leukocytes, dendritic cells and endothelial cells, and mechanisms by which DVs enhance vascular permeability are just beginning to be define...
  14. Christie P Thomas; Fiscal Year: 2014
    ..that regulate sFlt1 and the elucidation of the effects of sFlt1 on signaling pathways in glomerular endothelial cells has broad implication for the study of proteinuric kidney diseases and may provide new therapies for ..
  15. PATHOPHYSIOLOGY OF THE ENDOTHELIUM
    Francis W Luscinskas; Fiscal Year: 2013
    ..The results of these proposed studies should yield valuable new insights into how vascular endothelial cells actively participate in the regulation of the inflammatory process, which is central to so many ..
  16. Tumor Microenvironment Interactions in Brain Tumors
    Eric C Holland; Fiscal Year: 2010
    ..The central hypothesis is that stromal cells, particularly macrophages and endothelial cells, provide key factors, such as matrix-degrading enzymes, which are co-opted by the tumor to promote its own ..
  17. Edward P Feener; Fiscal Year: 2016
    ..Using cultured retinal microvessel endothelial cells and astrocytes, we have identified both bradykinin-dependent and -independent mechanisms of kallikrein ..
  18. Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for Cerebr
    LEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2012
    ..Finally, the compounds will also be tested in an in vitro system of co-culture of human brain endothelial cells and P. falciparum. We expect that to define one or more compounds that can be forwarded for clinical trials...
  19. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
    ..or IL-12 -treated decidual cells on CTB invasion and vascular remodeling using co-culture of CTBs, APCs and endothelial cells;4) use a novel MF- or DC-depleted PET mouse model to evaluate the effects of activated APCs on the ..
  20. Iris Z Jaffe; Fiscal Year: 2016
    ..MR is expressed and regulates gene transcription programs in human vascular smooth muscle cells (VSMC) and endothelial cells. In animal models of vascular injury and atherosclerosis, aldo infusion increases vascular remodeling and ..
  21. Huaizhu Wu; Fiscal Year: 2016
    ..on blood monocytes and AT macrophages;(2) CD11c contributes to monocyte adhesion and migration on inflamed endothelial cells (ECs) by binding vascular cell adhesion molecule-1 (VCAM-1);and (3) deficiency of CD11c in obese mice ..
  22. Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
    Lauren M Pachman; Fiscal Year: 2013
    ..Damage to endothelial cells is mediated by IFN- 1 and TNF-1, and both cytokines are increased in JDM sera and tissue...
  23. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    Thomas Ortel; Fiscal Year: 2010
    ..platelet membranes requires expressionof phosphatidylserine (PS) on the surface of activated platelets or endothelial cells. The long-term goal of this project is to use integrated molecular, structural and biophysical approaches to ..
  24. JAMES RUSSELL SOWERS; Fiscal Year: 2016
    ..the relationship between Ang II/aldosterone/WD and S6K1 activation and INS signaling in primary cultured endothelial cells, vascular smooth muscle cells and cardiomyocytes...
  25. Mechanisms of Angiogenesis in Retinopathy of Prematurity
    Mary Elizabeth Hartnett; Fiscal Year: 2009
    ..oxygen fluctuations upregulate Mueller cell VEGF and increase VEGF-VEGFR2 signaling in dividing endothelial cells (ECs) at the migrating front to disorient mitotic EC cleavage planes and interfere with developmental ..
  26. Histone Chaperones in Angiogenesis
    Soumen Paul; Fiscal Year: 2012
    ..Earlier, we found that Vegfr1 transcription is rapidly induced in endothelial cells in response to angiogenic signals, mediated by fibroblast growth factor 2 and epidermal growth factor...
  27. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010
    ..receptor resulting in vasodilatation, plasma extravasation, and up-regulation of VCAM-1 and ICAM-1 on endothelial cells. Substance P may directly stimulate immune and epithelial cells via the neurokinin-1 receptor, causing the ..
  28. Treatment of Inflammatory Bowel Disease with Ceramidase Inhibitors
    Lynn W Maines; Fiscal Year: 2012
    ..of sphingomyelinases, neutral ceramidase and sphingosine kinases within gastrointestinal epithelial and endothelial cells drives the inflammation processes in IBD...
  29. Enrico M Novelli; Fiscal Year: 2016
    ..proposal also show that the specific TSP1-CD47 ligand receptor interaction not only inhibits NO signaling in endothelial cells, but also increases reactive oxygen species (ROS) production and endothelin A (ETA) receptor expression in ..
  30. Heather L Francis; Fiscal Year: 2015
    ..of HDC in liver sections and purified liver cells including cholangiocytes, hepatocytes and vascular endothelial cells;and (ii) in vivo effects of the modulation of HDC expression on biliary growth/damage in models of a...
  31. MARY ELIZABETH RUTH HARTNETT; Fiscal Year: 2016
    ..and relative tissue hypoxia upregulate Mueller cell VEGF and increases VEGF-VEGFR2 signaling in dividing endothelial cells (ECs) at the migrating front to disorient mitotic EC cleavage planes and interfere with normal retinal ..
  32. Todd W Rice; Fiscal Year: 2014
    ..These free radicals also interact with endothelial cells, especially in the lung, via lipid peroxidation causing altered membrane fluidity and function and the ..
  33. Na+/H+-exchanger-1 and Diabetic Neuropathy
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..NHE-1-driven activation of the upper part of glycolysis, under conditions of diabetes-induced inhibition (endothelial cells) or insufficient activation (Schwann cells, SC) of glyceraldehyde- 3-phosphate dehydrogenate, underlies ..
  34. Neuropilin and semaphorin, anti-angiogenesis activities and mechanisms
    Michael Klagsbrun; Fiscal Year: 2009
    ..was initially shown to repel axons and collapse growth cones but it also induces morphological changes in endothelial cells (EC) and tumor cells characterized by inactivation of RhoA, loss of stress fibers, collapse of the F-actin ..
  35. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..Fluorescent probes will be used to label the tubular scaffold and the two main cell types of blood vessels (endothelial cells lining the lumen, and smooth muscle cells in the wall)...
  36. Scavenging of Reactive Oxygen and Nitrogen Species by Cobalamins
    NICOLA ELIZABETH BRASCH; Fiscal Year: 2011
    ..In Specific Aim 2 CNCbl's ability to scavenge excess ROS and RNS in primary human aortic endothelial cells and prevent ROS/RNS-initiated cell death will be determined...
  37. Role of Matrix Metalloproteinase-1 in Endothelial Cell Senescence
    Catherine D Mao; Fiscal Year: 2010
    ..We have previously shown that lithium induces a cell cycle arrest in primary endothelial cells associated with the activation of the tumor suppressor p53 and p21cip cascade and the development of a cell ..
  38. Sheng He Huang; Fiscal Year: 2014
    ..transmigration (PMNT) across the blood-brain barrier (BBB), which consists mainly of brain microvascular endothelial cells (BMEC)...
  39. Bingmei M Fu; Fiscal Year: 2014
    ..The higher shear rates/stresses and shear rate/stress gradients activate the endothelial cells and the tumor cells (specifically, activate cell adhesion molecules and endothelial nitric oxide synthase) ..
  40. Margaret Markiewicz; Fiscal Year: 2014
    ..in the regulation of vessels stabilization such as PDGFB, VE-cadherin, N-cadherin were downregulated in the endothelial cells isolated from ER ? -/- mice...
  41. Genomic adaptation to HIV infection of the CNS in opioid-abusers
    Rajnish S Dave; Fiscal Year: 2012
    ..miRNA expression profiles in human fetal brain derived cultures of microglia, astrocytes, oligodendrocytes, endothelial cells, and neurons infected with HIV and/or treated with morphine...
  42. Serpil C Erzurum; Fiscal Year: 2016
    ..The excessive growth of the vascular endothelial cells is the focus of our research...
  43. LYNETTE KAY ROGERS; Fiscal Year: 2015
    ..RAGE is highly expressed in lung;specifically epithelial type I cells, endothelial cells, and alveolar macrophages...
  44. YVES CLAUDE GORIN; Fiscal Year: 2014
    ..A major defense of endothelial cells against vascular injury is endothelial nitric oxide synthase (eNOS), which generates nitric oxide (NO) in ..
  45. Role of TLR-4 in Lung Reperfusion Injury
    MICHAEL SCOTT MULLIGAN; Fiscal Year: 2013
    ..which may allow for AM activation of other cells including type 2 pneumocytes (T2P) and pulmonary artery endothelial cells (PAEC)...
  46. Mechanisms of Astrocyte Development
    Teri L Belecky Adams; Fiscal Year: 2010
    ..Second, a subpopulation of the astrocyte precursor cells migrates into the eye where they beckon to endothelial cells from outside the eye to enter and act as the substrate upon which the endothelial cells form the primary ..
  47. TIMOTHY TUN HLA; Fiscal Year: 2016
    ..Given that S1P is abundant in plasma, spatially- and temporally-regulated expression of S1P receptors in endothelial cells is a major determinant of the biological response of S1P in a given vascular bed...
  48. Regulation of the Endothelial Citrulline-Nitric Oxide Cycle
    Duane C Eichler; Fiscal Year: 2010
    ..Since virtually all phenotypic properties of normally functioning endothelial cells are related to the bioactivity of NO, impairment of NO production is a common mechanism by which ..
  49. HUA LINDA CAI; Fiscal Year: 2016
    ..We propose an innovative hypothesis that cardiac microvascular endothelial cells signal to adjacent cardiomyocytes to induce cardioprotection, under conditions such as netrin-1 reperfusion...
  50. Linda M Graham; Fiscal Year: 2014
    ..We will investigate how oxidized lipids block the movement of endothelial cells (cells that normally line blood vessels) into an area of injury or onto a bypass graft...
  51. David C Johnson; Fiscal Year: 2016
    ..relate to the fact that extensively studied laboratory strains of HCMV fail to enter M/M, epithelial and endothelial cells. Clinical strains of HCMV enter all these diverse cell types, apparently because these viruses express two ..
  52. CCR3: a molecular marker for neovascular AMD
    Jayakrishna Ambati; Fiscal Year: 2010
    ..receptor best known for promoting eosinophil and mast cell trafficking, is expressed in human choroidal endothelial cells in vivo only in the setting of CNV due to AMD...
  53. Site-directed Chemotherapy for Breast Cancer using Novel Angiogenesis Inhibitor
    Shaker A Mousa; Fiscal Year: 2010
    ..Experiments will be performed to evaluate the functional activities of TclNPs in vitro in MCF7 cells and in endothelial cells. Preliminary data using fluorescence microscopy showed that fluorescein-loaded TclNPs localize ..
  54. Control of Drug Delivery to the CNS: Modulating P-glycoprotein Activity
    William A Banks; Fiscal Year: 2013
    ..Recent in vitro work with brain endothelial cells has demonstrated a cascade of events that regulate P-gp activity...
  55. Effect of HIV protease inhibitor on alcohol induced ER stress and liver injury.
    Cheng Ji; Fiscal Year: 2013
    ..administered HIV PIs;(4) to isolate non-parenchymal cells (hepatic stellate cells, Kupffer cells, and endothelial cells) and differentiate HIV PI- or alcohol-induced ER stress response in these cell types;(5) to determine in ..
  56. VEGF Regulation of Hepatic Erythropoietin Synthesis
    Calvin Kuo; Fiscal Year: 2009
    ..Conversely, co-culture experiments manipulating VEGF will be used to test the effects of endothelial cells on hepatocyte Epo production...
  57. Howard E Gendelman; Fiscal Year: 2016
    ..Our drug formulations can readily cross the blood- brain barrier (BBB), from monocytes to endothelial cells, and enable drug transfer to and from an infected CNS...
  58. Genome-wide DNA Methylation Profiles Associated with Abnormal Intrauterine Growth
    Cristina Montagna; Fiscal Year: 2013
    ..cell types (lymphocytes and leukocytes from umbilical cord and maternal peripheral blood and umbilical vein endothelial cells)...
  59. Stem Cell Based Therapy For Radiation Induced Gastrointestinal Syndrome
    Chandan Guha; Fiscal Year: 2010
    ..syndrome (RIGS) results from a combination of direct cytocidal effects on intestinal crypt and endothelial cells and subsequent loss of the mucosal barrier, resulting in microbial infection, septic shock and systemic ..
  60. Vladimir V Kalinichenko; Fiscal Year: 2016
    ..approaches for BPD treatment include increasing postnatal angiogenesis and protection of alveolar endothelial cells from apoptosis after the injury caused by mechanical ventilation and high levels of oxygen...
  61. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay K Kaul; Fiscal Year: 2012
    ..Moreover, we show that hypoxia induces marked activation of HIF-1[unreadable] in vascular endothelial cells. Under Specific Aim 2, we will test the hypothesis that, in SCD, HIF-1[unreadable] activation will ..
  62. Sterile Hepatic Inflammation
    Wajahat Zafar Mehal; Fiscal Year: 2012
    ..iii) DNA from apoptotic hepatocytes can activate TLR9 on sinusoidal endothelial cells, and cause liver injury...
  63. Role of chemokines in astro-neuronal activation in cerebral malaria
    Monique Stins; Fiscal Year: 2009
    ..Therefore we investigated the response of human brain micro-vascular endothelial cells (HBMEC) to Pf-IRBC exposure...
  64. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
    ..The cadherin Neural Cell Adhesion Molecule (NCAM) is key in leukocyte adhesion to endothelial cells. Upon signaling by chemokines such as MCP1 leukocytes are drawn toward endothelial cells...
  65. ENDOTHELIAL INJURY AND CYTOPROTECTION
    JACK HAWIGER; Fiscal Year: 1993
    ..exposure of the binding sites (receptors) for fibrinogen and fibrin monomer on the luminal membrane of the endothelial cells, initiating clinically silent or apparent thrombosis...
  66. Modulation of Monocarboxylic Acid Transporter Kinetic Function for Stroke Therapy
    JEFFREY PAUL SMITH; Fiscal Year: 2010
    ..which Protein Kinase A (PKA) regulates the function of Monocarboxylic Acid Transporter 1 (MCT1) in rat brain endothelial cells. We hypothesize that PKA regulates MCT1 through a multi-protein regulatory complex called a transducisome...
  67. Homing of Stem Cells in Stroke Therapeutics
    EVAN YALE contact SNYDER; Fiscal Year: 2010
    ..administration of either UCSCs or NSCs for mediating brain repair following stroke, rolling &adhesion on endothelial cells is the critical 1st step in the homing cascade that is necessary for targeting these cells to the injured ..
  68. Anti-HLA Antibody Activation of Endothelial Cells in Cardiac Transplantation
    Elaine F Reed; Fiscal Year: 2010
    ..because ligation of class I and class II molecules by anti-HLA antibodies initiates intracellular signals in endothelial cells that synergize with growth factor receptors to elicit cell survival and cell proliferation...
  69. Nitric Oxide in Pulmonary Hypertension
    Serpil Erzurum; Fiscal Year: 2009
    ..The excessive growth of the vascular endothelial cells is the focus of our research...
  70. Zipcode based nano-imaging of hypertensive pulmonary arteries
    Rubin M Tuder; Fiscal Year: 2010
    ..Given the unique phenotypic characteristics of endothelial cells in hypertensive pulmonary vascular lesions, we propose to discover peptide/receptor pairs that will permit ..
  71. ALCOHOL AND LIVER ENDOTHELIAL CELLS IN IMMUNE RESPONSES
    Geoffrey Thiele; Fiscal Year: 1999
    ..This grant proposes work which will begin to address the role of liver endothelial cells in activating the immune system and exacerbating alcohol liver disease...
  72. Directed Self Assembly of Complex Branching Micro-Tissues
    JEFFREY R contact MORGAN; Fiscal Year: 2010
    ..cell line (H35), smooth muscle cells (SMC) and two endothelial cell lines;human umbilical cord vein endothelial cells (HUVEC) and calf pulmonary artery endothelial cells (CPAE) to test the following specific aims: Aim 1...
  73. ENDOTHELIAL CELL DIVERSITY DURING FETAL DEVELOPMENT
    Eugene Levin; Fiscal Year: 2001
    Studies of the structural and functional characteristics of endothelial cells in vivo and in vitro have established that the vascular endothelium is made up of a phenotypically diverse group of cells...
  74. Human Blood-Brain Barrier Model for CNS Drug Translation
    Eric V Shusta; Fiscal Year: 2010
    ..An in vitro BBB model typically consists of a monolayer of brain endothelial cells (EC) that is grown on a permeable membrane...
  75. HIV-induced 5-Lipoxygenase: Role in HIV-related Pulmonary Arterial Hypertension
    KRISTI MICHELLE PORTER; Fiscal Year: 2010
    ..We have found that HIV-1 transgenic rats and HIV-1-treated co-cultures containing human pulmonary artery endothelial cells (HPAEC) and peripheral blood mononuclear cells (PBMC) demonstrate striking increases in arachidonate 5-..
  76. Mechanisms of HAART-Induced Endothelial Dysfunction
    Krishna Agrawal; Fiscal Year: 2006
    ..the molecular mechanism/s involved in highly active anti-retroviral therapy (HAART)-induced dysfunctions in endothelial cells (ECs)...
  77. Endothelial BK Channel Regulation by Caveolae Targeting
    Hon Chi Lee; Fiscal Year: 2010
    ..that the large conductance Ca2+-activated K+ (BK) channels are targeted to caveolae in bovine aortic endothelial cells (BAEC)...
  78. VEGFs in Artery-Vein Imbalance in AIDS-Kaposi Sarcoma
    Parkash Gill; Fiscal Year: 2009
    Kaposi's sarcoma (KS) develops as a vascular proliferate process in response to infection of endothelial cells or their precursors with HHV-8...
  79. SIGNALS FOR RENAL ENDOTHELIAL CAPILLARY MORPHOGENESIS
    Jin Chen; Fiscal Year: 2001
    ..The proposal hypothesizes that renal and other microvascular endothelial cells discriminate appropriate partners for vascular structure assembly based on signals they receive upon ..
  80. GATA Factor Regulation of Vascular Endothelium
    EMERY BRESNICK; Fiscal Year: 2009
    The development of hallmark features of endothelial cells relies upon endothelial cell-specific transcriptional mechanisms. Multiple factors, including GATA-2, establish endothelial cell-specific transcription...
  81. STROMAL INFLUENCES ON BREAST CANCER PROGRESSION
    SANDRA MCLESKEY; Fiscal Year: 1999
    ..Evidence is also accumulating that endothelial cells from specific tissues differ, and that endothelial cells from tumors are different from those in normal ..