cultured tumor cells

Summary

Summary: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.

Top Publications

  1. ncbi Involvement of chemokine receptors in breast cancer metastasis
    A Muller
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 410:50-6. 2001
  2. ncbi Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    P J Morin
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 275:1787-90. 1997
  3. ncbi Requirement for p53 and p21 to sustain G2 arrest after DNA damage
    F Bunz
    The Howard Hughes Medical Institute and The Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 282:1497-501. 1998
  4. ncbi Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    V Korinek
    Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
    Science 275:1784-7. 1997
  5. ncbi Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    P Li
    Howard Hughes Medical Institute, and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Cell 91:479-89. 1997
  6. ncbi Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
    H Walczak
    Immunex Corporation, Seattle, Washington 98101, USA
    Nat Med 5:157-63. 1999
  7. ncbi Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
    R U Jänicke
    Institute of Molecular and Cell Biology, The National University of Singapore, 30 Medical Drive, Singapore 117609, Republic of Singapore
    J Biol Chem 273:9357-60. 1998
  8. ncbi The receptor for the cytotoxic ligand TRAIL
    G Pan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Science 276:111-3. 1997
  9. ncbi Mutations of the BRAF gene in human cancer
    Helen Davies
    Cancer Genome Project, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK
    Nature 417:949-54. 2002
  10. ncbi Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone
    Russell S Taichman
    Department of Periodontics, Prevention, and Geriatrics, and the Center for Biorestoration of Oral Health, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Cancer Res 62:1832-7. 2002

Detail Information

Publications278 found, 100 shown here

  1. ncbi Involvement of chemokine receptors in breast cancer metastasis
    A Muller
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 410:50-6. 2001
    ..Our findings indicate that chemokines and their receptors have a critical role in determining the metastatic destination of tumour cells...
  2. ncbi Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    P J Morin
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 275:1787-90. 1997
    ..These results indicate that regulation of beta-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or beta-catenin...
  3. ncbi Requirement for p53 and p21 to sustain G2 arrest after DNA damage
    F Bunz
    The Howard Hughes Medical Institute and The Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 282:1497-501. 1998
    ..Thus, p53 and p21 appear to be essential for maintaining the G2 checkpoint in human cells...
  4. ncbi Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    V Korinek
    Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
    Science 275:1784-7. 1997
    ..Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium...
  5. ncbi Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    P Li
    Howard Hughes Medical Institute, and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Cell 91:479-89. 1997
    ....
  6. ncbi Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
    H Walczak
    Immunex Corporation, Seattle, Washington 98101, USA
    Nat Med 5:157-63. 1999
    ..17 (SCID) mice, and histologic examination of tumors from SCID mice treated with LZ-huTRAIL demonstrated clear areas of apoptotic necrosis within 9-12 hours of injection...
  7. ncbi Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
    R U Jänicke
    Institute of Molecular and Cell Biology, The National University of Singapore, 30 Medical Drive, Singapore 117609, Republic of Singapore
    J Biol Chem 273:9357-60. 1998
    ..These results indicate that although caspase-3 is not essential for TNF- or staurosporine-induced apoptosis, it is required for DNA fragmentation and some of the typical morphological changes of cells undergoing apoptosis...
  8. ncbi The receptor for the cytotoxic ligand TRAIL
    G Pan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Science 276:111-3. 1997
    ..Thus, the DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis...
  9. ncbi Mutations of the BRAF gene in human cancer
    Helen Davies
    Cancer Genome Project, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK
    Nature 417:949-54. 2002
    ..As BRAF is a serine/threonine kinase that is commonly activated by somatic point mutation in human cancer, it may provide new therapeutic opportunities in malignant melanoma...
  10. ncbi Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone
    Russell S Taichman
    Department of Periodontics, Prevention, and Geriatrics, and the Center for Biorestoration of Oral Health, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Cancer Res 62:1832-7. 2002
    ..Collectively, these results suggest that prostate cancers and perhaps other neoplasms may use the SDF-1/CXCR4 pathway to spread to bone...
  11. ncbi A system for stable expression of short interfering RNAs in mammalian cells
    Thijn R Brummelkamp
    Division of Molecular Carcinogenesis, Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands
    Science 296:550-3. 2002
    ..Therefore, the pSUPER vector constitutes a new and powerful system to analyze gene function in a variety of mammalian cell types...
  12. ncbi Inhibition of death receptor signals by cellular FLIP
    M Irmler
    Institute of Biochemistry, Lausanne Branch, University of Lausanne, Switzerland
    Nature 388:190-5. 1997
    ..High levels of FLIP(L) protein are also detectable in melanoma cell lines and malignant melanoma tumours. Thus FLIP may be implicated in tissue homeostasis as an important regulator of apoptosis...
  13. ncbi BRAF and RAS mutations in human lung cancer and melanoma
    Marcia S Brose
    Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia 19104, USA
    Cancer Res 62:6997-7000. 2002
    ..Although uncommon, BRAF mutations in human lung cancers may identify a subset of tumors sensitive to targeted therapy...
  14. ncbi A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
    P van der Bruggen
    Ludwig Institute for Cancer Research, Brussels, Belgium
    Science 254:1643-7. 1991
    ..Thus, precisely targeted immunotherapy directed against antigen MZ2-E could be provided to individuals identified by HLA typing and analysis of the RNA of a small tumor sample...
  15. ncbi The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    A Cano
    Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Cell Biol 2:76-83. 2000
    ..Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs...
  16. ncbi Relevance of breast cancer cell lines as models for breast tumours: an update
    Marc Lacroix
    Laboratoire Jean Claude Heuson de Cancérologie Mammaire, Institut Jules Bordet, Universite Libre de Bruxelles, Bruxelles, Belgium
    Breast Cancer Res Treat 83:249-89. 2004
    ..Investigations on additional specific lines are expected to improve our knowledge of BCC and of the dialogue that these maintain with their surrounding normal cells in vivo...
  17. ncbi Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    Haidong Dong
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Nat Med 8:793-800. 2002
    ..These findings have implications for the design of T cell-based cancer immunotherapy...
  18. ncbi A family of cytokine-inducible inhibitors of signalling
    R Starr
    The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia
    Nature 387:917-21. 1997
    ..Transcription of all four SOCS genes is increased rapidly in response to interleukin-6, in vitro and in vivo, suggesting they may act in a classic negative feedback loop to regulate cytokine signal transduction...
  19. ncbi Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
    J Behrens
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13122 Berlin, Germany
    Science 280:596-9. 1998
    ..Thus, conductin is a component of the multiprotein complex that directs beta-catenin to degradation and is located downstream of APC. In Xenopus embryos, conductin interfered with wnt-induced axis formation...
  20. pmc Significance analysis of microarrays applied to the ionizing radiation response
    V G Tusher
    Departments of Medicine and Biochemistry, Stanford University, 269 Campus Drive, Center for Clinical Sciences Research 1115, Stanford, CA 94305-5151, USA
    Proc Natl Acad Sci U S A 98:5116-21. 2001
    ..Surprisingly, four nucleotide excision repair genes were induced, suggesting that this repair pathway for UV-damaged DNA might play a previously unrecognized role in repairing DNA damaged by ionizing radiation...
  21. ncbi An antagonist decoy receptor and a death domain-containing receptor for TRAIL
    G Pan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA
    Science 277:815-8. 1997
    ..Another death domain-containing receptor for TRAIL (designated as death receptor-5), which preferentially engaged a FLICE (caspase-8)-related death protease, was also identified...
  22. ncbi Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation
    J Brognard
    Developmental Therapeutics Department, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20889, USA
    Cancer Res 61:3986-97. 2001
    ....
  23. ncbi Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro
    Tatyana N Ignatova
    Departments of Neuroscience and Neurosurgery, McKnight Brain Institute and Shands Cancer Center, University of Florida, Gainesville, Florida 32610, USA
    Glia 39:193-206. 2002
    ..Moreover, tumor stem-like cells with genetically defective responses to epigenetic stimuli may contribute to gliomagenesis and the developmental pathological heterogeneity of glial tumors...
  24. pmc PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs
    T C He
    Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cell 99:335-45. 1999
    ..These findings suggest that NSAIDs inhibit tumorigenesis through inhibition of PPARdelta, the gene for which is normally regulated by APC...
  25. ncbi Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors
    J P Sheridan
    Department of Molecular Oncology, Genentech, South San Francisco, CA 94080 4918, USA
    Science 277:818-21. 1997
    ..DcR1 acted as a decoy receptor that inhibited TRAIL signaling. Thus, a cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli...
  26. ncbi Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
    S Bauer
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Science 285:727-9. 1999
    ..These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses...
  27. ncbi Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
    S P Cole
    Cancer Research Laboratories, Queen s University, Kingston, Ontario, Canada
    Science 258:1650-4. 1992
    ..1. Reversion to drug sensitivity was associated with loss of gene amplification and a marked decrease in mRNA expression. The mRNA encodes a member of the ATP-binding cassette transmembrane transporter superfamily...
  28. pmc beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
    Valerie M Weaver
    Department of Pathology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cancer Cell 2:205-16. 2002
    ..These results indicate that integrin-induced polarity may drive tumor cell resistance to apoptosis-inducing agents via effects on NFkappaB...
  29. ncbi Identification and expansion of the tumorigenic lung cancer stem cell population
    A Eramo
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Cell Death Differ 15:504-14. 2008
    ..Molecular and functional characterization of such a tumorigenic population may provide valuable information to be exploited in the clinical setting...
  30. ncbi Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF
    E J Filardo
    Department of Medicine and Surgery, Rhode Island Hospital and Brown University, Providence 02903, USA
    Mol Endocrinol 14:1649-60. 2000
    ..Our data imply that ER-negative breast tumors that continue to express GPR30 may use estrogen to drive growth factor-dependent cellular responses...
  31. ncbi A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
    M Enari
    Department of Genetics, Osaka University Medical School, Suita, Japan
    Nature 391:43-50. 1998
    ....
  32. ncbi NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4
    Gregory Helbig
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Biol Chem 278:21631-8. 2003
    ..Taken together, these results implicate NF-kappaB in the migration and the organ-specific homing of metastatic breast cancer cells...
  33. ncbi Sustained loss of a neoplastic phenotype by brief inactivation of MYC
    Meenakshi Jain
    Division of Oncology, Departments of Medicine and Pathology, Stanford University, Stanford, CA 94305 5151, USA
    Science 297:102-4. 2002
    ..These results raise the possibility that transient inactivation of MYC may be an effective therapy for certain cancers...
  34. ncbi Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
    M Tamura
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892 4370, USA
    Science 280:1614-7. 1998
    ..Overexpression of FAK partially antagonized the effects of PTEN. Thus, PTEN phosphatase may function as a tumor suppressor by negatively regulating cell interactions with the extracellular matrix...
  35. pmc Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas
    B Mann
    Department of Surgery, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, 12200 Berlin, Germany
    Proc Natl Acad Sci U S A 96:1603-8. 1999
    ..Together with the other alterations, beta-catenin accumulation may contribute to the development and progression of colon carcinoma both by dedifferentiation and through proteolytic activity...
  36. ncbi The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
    Marc van de Wetering
    Department of Immunology and Center for Biomedical Genetics, University Medical Center, 3584 CX, Utrecht, The Netherlands
    Cell 111:241-50. 2002
    ..Thus, the beta-catenin/TCF-4 complex constitutes the master switch that controls proliferation versus differentiation in healthy and malignant intestinal epithelial cells...
  37. ncbi Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
    Y Lu
    Department of Oncology, Jewish General Hospital, and McGill University, Montreal, PQ, Canada
    J Natl Cancer Inst 93:1852-7. 2001
    ..Thus, strategies that target IGF-IR signaling may prevent or delay development of resistance to trastuzumab...
  38. pmc Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion
    Q Yu
    Molecular Pathology Unit and MGH Cancer Center, Massachusetts General Hospital, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02129, USA
    Genes Dev 13:35-48. 1999
    ..Our observations indicate that CD44 serves to anchor MMP-9 on the cell surface and define a mechanism for CD44-mediated tumor invasion...
  39. ncbi Association of the APC tumor suppressor protein with catenins
    L K Su
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 262:1734-7. 1993
    ..A 27-residue fragment of APC containing a 15-amino acid repeat was sufficient for the interaction with the catenins. These results suggest an important link between tumor initiation and cell adhesion...
  40. ncbi Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway
    P M Chaudhary
    Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Immunity 7:821-30. 1997
    ..Thus, both DR5 and DR4 use FADD, TRADD, and RIP in their signal transduction pathways, and FADD is the common mediator of apoptosis by all known death domain-containing receptors...
  41. ncbi CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles
    Dagmar Beier
    Laboratory of Neurooncology, University of Regensburg, Regensburg, Germany
    Cancer Res 67:4010-5. 2007
    ..investigate whether different subtypes of glioblastomas might originate from different cells of origin, we cultured tumor cells from 22 glioblastomas under medium conditions favoring the growth of neural and cancer stem cells (CSC)...
  42. ncbi Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death
    Alexander Arlt
    1Laboratory of Molecular Gastroenterology and Hepatology, 1st Department of Medicine, University of Kiel, Germany
    Oncogene 22:3243-51. 2003
    ....
  43. ncbi Molecular determinants for the tissue specificity of SERMs
    Yongfeng Shang
    Department of Adult Oncology, Dana Farber Cancer Institute, 44 Binney Street, and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 295:2465-8. 2002
    ..Thus cell type- and promoter-specific differences in coregulator recruitment determine the cellular response to SERMs...
  44. ncbi A multigenic program mediating breast cancer metastasis to bone
    Yibin Kang
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer Cell 3:537-49. 2003
    ....
  45. ncbi A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform
    Bence Sipos
    Department of Pathology, University of Kiel, Germany
    Virchows Arch 442:444-52. 2003
    ..We conclude that the proposed ultrastructural grading system combined with the proliferative activity provides a basis for further comparative studies of pancreatic ductal adenocarcinoma cell lines...
  46. ncbi Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB
    R Ravi
    Johns Hopkins Oncology Center, The Johns Hopkins University School of Medicine, Bunting-Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Nat Cell Biol 3:409-16. 2001
    ..The ability to induce death receptors or Bcl-xL may explain the dual roles of NF-kappaB as a mediator or inhibitor of cell death during immune and stress responses...
  47. ncbi Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
    M Kaghad
    Sanofi Recherche, Labege, France
    Cell 90:809-19. 1997
    ..We propose that the disregulation of p73 contributes to tumorigenesis and that p53-related proteins operate in a network of developmental and cell cycle controls...
  48. ncbi The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers
    Kwai Wa Cheng
    Department of Molecular Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA
    Nat Med 10:1251-6. 2004
    ..Overall, these studies implicate RAB25, and thus the RAB family of small G proteins, in aggressiveness of epithelial cancers...
  49. ncbi The polycomb group protein EZH2 is involved in progression of prostate cancer
    Sooryanarayana Varambally
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nature 419:624-9. 2002
    ..Thus, dysregulated expression of EZH2 may be involved in the progression of prostate cancer, as well as being a marker that distinguishes indolent prostate cancer from those at risk of lethal progression...
  50. ncbi Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium
    D Z Chen
    North Shore-Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    J Nutr 131:3294-302. 2001
    ....
  51. ncbi Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models
    K P Bhat
    Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Cancer Res 61:7456-63. 2001
    ..In rodent models, carcinogen-induced preneoplastic lesions and mammary tumors are inhibited. These data suggest that resveratrol may have beneficial effects if used as a chemopreventive agent for breast cancer...
  52. ncbi A matrix metalloproteinase expressed on the surface of invasive tumour cells
    H Sato
    Department of Molecular Virology and Oncology, School of Medicine, Kanazawa University, Ishikawa, Japan
    Nature 370:61-5. 1994
    ..The new metalloproteinase may thus trigger invasion by tumour cells by activating pro-gelatinase A on the tumour cell surface...
  53. ncbi Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells
    Janice M Knowlden
    Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3XF, United Kingdom
    Endocrinology 144:1032-44. 2003
    ..These results demonstrate that TAM-R MCF-7 cell growth is mediated by the autocrine release and action of an EGFR-specific ligand inducing preferential EGFR/c-erbB2 dimerization and downstream activation of the ERK pathway...
  54. pmc Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor
    D Vercammen
    Laboratory of Molecular Biology, Flanders Interuniversity Institute for Biotechnology and University of Ghent, B 9000 Ghent, Belgium
    J Exp Med 187:1477-85. 1998
    ..These results indicate an involvement of caspases in protection against TNF-induced formation of oxygen radicals and necrosis...
  55. ncbi CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells
    Jian Wang
    Department of Biomedicine, University of Bergen, Bergen, Norway
    Int J Cancer 122:761-8. 2008
    ..Thus, our findings do not suggest that CD133 expression is required for brain tumor initiation, but that it may be involved during brain tumor progression...
  56. pmc A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
    L D Mayo
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 98:11598-603. 2001
    ..The demonstration that PI3-kinase/Akt signaling affects Mdm2 localization provides insight into how this pathway, which is inappropriately activated in many malignancies, affects the function of p53...
  57. ncbi CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion
    Jolanta Libura
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Blood 100:2597-606. 2002
    ....
  58. ncbi Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells
    M Jane Arboleda
    Department of Medicine, Division of Hematology and Oncology, University of California Los Angeles, UCLA School of Medicine, Los Angeles, California 90095, USA
    Cancer Res 63:196-206. 2003
    ..Taken together, these data indicate that AKT2 mediates PI3-K-dependent effects on adhesion, motility, invasion, and metastasis in vivo...
  59. ncbi APC binds to the novel protein EB1
    L K Su
    Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA
    Cancer Res 55:2972-7. 1995
    ..This conservation suggests an essential function for EB1 that might provide clues to the mechanism through which APC suppresses colonic neoplasia...
  60. ncbi Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression
    Simone Fulda
    University Children s Hospital, Prittwitzstr 43, D 89075 Ulm, Germany
    Oncogene 21:2283-94. 2002
    ..g. by Bcl-2 and by XIAP, these findings may have important clinical implication. Thus, strategies targeting the molecular basis of resistance towards TRAIL may be necessary in some tumors for cancer therapy with TRAIL...
  61. ncbi XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells
    E Asselin
    Department of Obstetrics and Gynaecology, University of Ottawa, Loeb Health Research Institute, The Ottawa Hospital, Ontario, Canada
    Cancer Res 61:1862-8. 2001
    ..These results demonstrate a novel mechanism by which XIAP regulates apoptosis and the possible involvement of the PI 3-K/Akt survival pathway in XIAP-mediated chemoresistance of ovarian cancer cells...
  62. ncbi Overexpression of histone deacetylase HDAC1 modulates breast cancer progression by negative regulation of estrogen receptor alpha
    Hideki Kawai
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 107:353-8. 2003
    ..Thus, HDAC1 may be a potential target for therapeutic intervention in the treatment of a subset of ER-negative breast cancers...
  63. ncbi Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
    Jeongwu Lee
    Neuro Oncology Branch, National Cancer Institute, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Cell 9:391-403. 2006
    ..These findings suggest that TSCs may be a more reliable model than many commonly utilized cancer cell lines for understanding the biology of primary human tumors...
  64. pmc beta-catenin is a target for the ubiquitin-proteasome pathway
    H Aberle
    Max Planck Institute for Immunobiology, Department of Molecular Embryology, Freiburg, Germany
    EMBO J 16:3797-804. 1997
    ..We show that ubiquitination of beta-catenin is greatly reduced in Wnt-expressing cells, providing the first evidence that the ubiquitin-proteasome degradation pathway may act downstream of GSK3beta in the regulation of beta-catenin...
  65. pmc Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis
    M J Smyth
    Cancer Immunology, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria 3002, Australia
    J Exp Med 193:661-70. 2001
    ..These results indicated that TRAIL induction on NK cells plays a critical role in IFN-gamma-mediated antimetastatic effects of IL-12 and alpha-GalCer...
  66. ncbi Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis
    Edward J Filardo
    Department of Surgery, Rhode Island Hospital, and Brown University, Providence, Rhode Island 02903, USA
    Mol Endocrinol 16:70-84. 2002
    ....
  67. ncbi Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer
    S D Catz
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, CA 92037, USA
    Oncogene 20:7342-51. 2001
    ..Concomitantly, bcl-2 p2 promoter studies in LNCaP cells show a 40-fold increase in promoter activity after stimulation with TNF-alpha in the absence of hormone...
  68. ncbi Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models
    C Y Li
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Natl Cancer Inst 92:143-7. 2000
    ..In this study, we attempted to monitor events at the initiation of angiogenesis at the earliest possible stage of tumor growth in vivo...
  69. ncbi Reversible tumorigenesis by MYC in hematopoietic lineages
    D W Felsher
    Department of Medicine, G W Hooper Foundation, San Francisco, California, USA
    Mol Cell 4:199-207. 1999
    ..We conclude that even though tumorigenesis is a multistep process, remediation of a single genetic lesion may be sufficient to reverse malignancy...
  70. ncbi A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells
    U Gunthert
    Institut fur Genetik, Universitat Karlsruhe, Federal Republic of Germany
    Cell 65:13-24. 1991
    ..Overexpression of pMeta-1 in the nonmetastasizing BSp73AS cells suffices to establish full metastatic behavior...
  71. pmc The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis
    S A Susin
    Centre National de la Recherche Scientifique UPR420, B P 8, F 94801 Villejuif, France
    J Exp Med 186:25-37. 1997
    ..In addition, they provide a plausible explanation of why Bcl-2 fails to interfere with Fas-triggered apoptosis in most cell types, yet prevents ceramide- and prooxidant-induced apoptosis...
  72. pmc Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner
    D H Nguyen
    Department of Biochemistry and Molecular Genetics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Cell Biol 146:149-64. 1999
    ..Thus, we have demonstrated that uPA promotes cellular migration, in an integrin-selective manner, by initiating a uPAR-dependent signaling cascade in which Ras, MEK, ERK, and MLCK serve as essential downstream effectors...
  73. ncbi Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production
    D Kim
    National Creative Research Initiative Center for Cell Growth Regulation, Korea Advanced Institute of Science and Technology, 373-1 Kusong-dong, Yusong, Taejon 305-701, Korea
    FASEB J 15:1953-62. 2001
    ..However, Akt/PKB did not affect the cell-cell or cell-matrix adhesion properties of HT1080. Our findings thus establish Akt/PKB as a major factor in the invasive abilities of cancer cells...
  74. ncbi p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells
    Y Hirose
    Brain Tumor Research Center, Department of Neurological Surgery, University of California San Francisco, 94143-0875, USA
    Cancer Res 61:1957-63. 2001
    ..Therefore, the integrity of the G2-M cell cycle checkpoint may be important in the cytotoxicity of TMZ in glioma cells...
  75. ncbi An essential part for Rho-associated kinase in the transcellular invasion of tumor cells
    K Itoh
    Department of Tumor Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
    Nat Med 5:221-5. 1999
    ..These results indicate that ROCK plays an essential part in tumor cell invasion, and demonstrate its potential as a therapeutic target for the prevention of cancer invasion and metastasis...
  76. ncbi Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol
    M Ploug
    Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark
    J Biol Chem 266:1926-33. 1991
    ..A similar proteolytic processing has been reported for other proteins that are linked to the plasma membrane by a glycosyl-phosphatidylinositol membrane anchor...
  77. ncbi Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia
    X Zhang
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 61:6050-4. 2001
    ..These studies thus identify VEGF as a novel target of the Wnt pathway in early colonic neoplasia and serve to underscore the importance of angiogenesis in premalignant disease...
  78. ncbi Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry
    M Farzan
    Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 96:667-76. 1999
    ..CXCR4, another important HIV-1 coreceptor, is also sulfated. Tyrosine sulfation may contribute to the natural function of many 7TMS receptors and may be a modification common to primate immunodeficiency virus coreceptors...
  79. pmc Molecular cytogenetic analysis of 11 new breast cancer cell lines
    F Forozan
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 4470, USA
    Br J Cancer 81:1328-34. 1999
    ..In summary, this set of breast cancer cell lines displaying prominent DNA amplifications should facilitate discovery and functional analysis of genes and signal transduction pathways contributing to breast cancer development...
  80. ncbi Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models
    Limin Hu
    Center for Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143 0556, USA
    Cancer Res 62:1087-92. 2002
    ..Our data suggest that a combination of a PI3k inhibitor and conventional chemotherapy may provide an effective approach to inhibiting tumor growth and ascites production in ovarian cancer with acceptable side effects...
  81. ncbi Limited penetration of anticancer drugs through tumor tissue: a potential cause of resistance of solid tumors to chemotherapy
    Ian F Tannock
    Department of Medical Oncology and Hematology and the Division of Experimental Therapeutics, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, M5G 2M9 Canada
    Clin Cancer Res 8:878-84. 2002
    ....
  82. ncbi FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
    M R Sprick
    Tumor Immunology Program, German Cancer Research Center DKFZ Heidelberg
    Immunity 12:599-609. 2000
    ..FADD/MORT1- and caspase-8-deficient Jurkat cells expressing only TRAIL-R2 were resistant to TRAIL-induced apoptosis. Thus, FADD/MORT1 and caspase-8 are essential for apoptosis induction via TRAIL-R2...
  83. ncbi Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9
    Sanjeev Banerjee
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 62:4945-54. 2002
    ..Overall, our results suggest that resveratrol suppresses DMBA-induced mammary carcinogenesis, which correlates with down-regulation of NF-kappaB, cyclooxygenase-2, and matrix metalloprotease-9 expression...
  84. ncbi Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein
    F Mueller-Pillasch
    Department of Internal Medicine I, University of Ulm, Germany
    Oncogene 14:2729-33. 1997
    ..However, the precise role of koc in human tumour cells is unknown and remains to be elucidated...
  85. ncbi A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    T T Paull
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0540, USA
    Curr Biol 10:886-95. 2000
    ..Recently it has been reported that a member of the histone H2A family, H2AX, becomes extensively phosphorylated within 1-3 minutes of DNA damage and forms foci at break sites...
  86. pmc Differential tumor surveillance by natural killer (NK) and NKT cells
    M J Smyth
    Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin and Repatriation Medical Centre, Heidelberg, 3084 Victoria, Australia
    J Exp Med 191:661-8. 2000
    ..This is the first description of an antitumor function for NKT cells in the absence of exogenously administered potent stimulators such as IL-12 or alpha-galactosylceramide...
  87. ncbi PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    J Li
    Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, New York, NY 10032, USA
    Science 275:1943-7. 1997
    ..These homologies suggest that PTEN may suppress tumor cell growth by antagonizing protein tyrosine kinases and may regulate tumor cell invasion and metastasis through interactions at focal adhesions...
  88. ncbi Baseline gene expression predicts sensitivity to gefitinib in non-small cell lung cancer cell lines
    Christopher D Coldren
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, C272, Denver, 80262, USA
    Mol Cancer Res 4:521-8. 2006
    ..Some of these genes could be targets of pharmacologic interventions to overcome primary resistance...
  89. ncbi CD4+ T cell--mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN gamma receptor expression by nonhematopoietic cells
    Z Qin
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Immunity 12:677-86. 2000
    ..This shows that an effective anti-tumor response involves communication between CD4+ T cells and nonhematopoietic cells, most likely within the tumor stroma, and that tumor immunity must not entirely rely on direct tumor cell killing...
  90. ncbi Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines
    K Nakatani
    Departments of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 274:21528-32. 1999
    ..These results indicate that Akt3 may contribute to the more aggressive clinical phenotype of the estrogen receptor-negative breast cancers and androgen-insensitive prostate carcinomas...
  91. ncbi A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor
    Kimita Suyama
    Derald H Ruttenberg Cancer Center, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Cancer Cell 2:301-14. 2002
    ..These results suggest that protection of the FGFR-1 from ligand-induced downregulation by N-cadherin enhances receptor signaling and provides a mechanism by which tumor cells can acquire metastatic properties...
  92. pmc Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis
    Katarina Wolf
    Department of Dermatology, University of Wurzburg, 97080 Wurzburg, Germany
    J Cell Biol 160:267-77. 2003
    ....
  93. ncbi The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation
    Tiffany M Phillips
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095 1714, USA
    J Natl Cancer Inst 98:1777-85. 2006
    ..Cancer-initiating cells can now be prospectively isolated from breast cancer cell lines and tumor samples and propagated as mammospheres in vitro under serum-free conditions...
  94. ncbi Identification of putative stem cell markers, CD133 and CXCR4, in hTERT-immortalized primary nonmalignant and malignant tumor-derived human prostate epithelial cell lines and in prostate cancer specimens
    Jun Miki
    Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Cancer Res 67:3153-61. 2007
    ..Expression of CXCR4 was also detected in CD133(+) cancer cells. These novel in vitro models may offer useful tools for the study of the biological features and functional integration of normal and cancer stem cells in prostate...
  95. ncbi The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
    H Hayashi
    Division of Gastroenterology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cell 89:1165-73. 1997
    ..These studies thus define a novel function for MAD-related proteins as intracellular antagonists of the type I kinase domain of TGFbeta family receptors...
  96. ncbi Binding of hepatitis C virus to CD81
    P Pileri
    IRIS, Chiron, Siena 53100, Italy
    Science 282:938-41. 1998
    ..Binding of E2 was mapped to the major extracellular loop of CD81. Recombinant molecules containing this loop bound HCV and antibodies that neutralize HCV infection in vivo inhibited virus binding to CD81 in vitro...
  97. pmc Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription
    S Chen
    Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, 48109, USA
    J Cell Biol 152:87-96. 2001
    ..These results provide the first demonstration that Wnt-1 inhibits cancer therapy-mediated apoptosis and suggests that Wnt-1 may exhibit its oncogenic potential through a mechanism of anti-apoptosis...
  98. ncbi The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases
    Roderick J Phillips
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, 90024, USA
    Am J Respir Crit Care Med 167:1676-86. 2003
    ..These data suggest that the CXCL12-CXCR4 biological axis is involved in regulating the metastasis of non-small cell lung cancer...
  99. pmc Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
    J Q Cheng
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 93:3636-41. 1996
    ..These data suggest that overexpression of AKT2 contributes to the malignant phenotype of a subset of human ductal pancreatic cancers...
  100. pmc HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    E Laughner
    Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-3914, USA
    Mol Cell Biol 21:3995-4004. 2001
    ..These data provide a molecular basis for VEGF induction and tumor angiogenesis by heregulin-HER2 signaling and establish a novel mechanism for the regulation of HIF-1alpha expression...
  101. ncbi Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis
    I Vlodavsky
    Department of Oncology, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Nat Med 5:793-802. 1999
    ..Cloning of the heparanase gene enables the development of specific molecular probes for early detection and treatment of cancer metastasis and autoimmune disorders...

Research Grants63

  1. Identification of LSD1 inhibitors targeting epigenetic regulation in tumor cells
    Patrick M Woster; Fiscal Year: 2013
    ..Evaluation of newly synthesized analogues as LSD1 inhibitors and study of their epigenetic effects in cultured tumor cells. Each analogue will be evaluated as an inhibitor of purified LSD1, and the kinetics of inhibition will be ..
  2. Oxygen as a master immunologic switch
    Christopher A Pennell; Fiscal Year: 2013
    ..There are numerous ongoing clinical trials that utilize cultured tumor cells as the source of vaccine antigen for the treatment of a wide array of tumors...
  3. cPLA2alpha and COX-2 in Cholangiocarcinoma
    Tong Wu; Fiscal Year: 2013
    ..effect of simultaneous inhibition of EP1 and EGFR on cholangiocarcinoma growth will be examined by using cultured tumor cells and experimental animal models...
  4. Annexin A2 as a Novel Enhancer of Tumor-Associated Antigen Processing
    BRIAN MAGNE ANDERSEN; Fiscal Year: 2013
    ..Little was known on the influence of oxygen on the immunogenicity of cultured tumor cells until our recent findings that culture in 5% O2 increases: (1) glioma-associated antigen expression (Ref 8);..
  5. Mechanisms of the hypoxic response underlying tumor progression
    L Eric Huang; Fiscal Year: 2012
    ..genetic instability through activation of HIF-1a-Myc pathway confers malignant traits such as invasion on cultured tumor cells in vitro and tumorigenicity, local invasion, and metastasis in tumor xenograft models...
  6. Bionanoconjugates for Detection of Circulating Tumor Cells in Lung Cancer
    Marc Knecht; Fiscal Year: 2012
    ..Sensitivity of the approach will be determined with peripheral blood spiked at various concentrations with cultured tumor cells with known antigen expression...
  7. Synthesis of Gold Nanoparticle-Cored Dendrimers Linked with Fluorophores and Anti
    YOUNG SHON; Fiscal Year: 2013
    ..4) Evaluation of cytotoxicity, cell recognition, and distribution of NCDs in cultured tumor cells. 5) Hyperthermia treatments in tumor cells...
  8. Mechanism and Uses of Transmembrane Helix Insertion by Soluble Peptides
    Yana K Reshetnyak; Fiscal Year: 2013
    ..the inserting end of pHLIP by a disulfide are delivered across membranes and released in the cytoplasms of cultured tumor cells at low pH. By continuing our basic research we hope to frame the technology for use in the clinic...
  9. Improved Suicide Gene Therapy for Hepatic Cancers
    William Ensminger; Fiscal Year: 2005
    ..generate sufficient cytotoxicity and radiosensitization because of an inadequate ability to kill adjacent cultured tumor cells that are not transduced ("bystander effect")...
  10. A High-Pressure Freezing and Cryoprocessing System for Northwestern University
    WILLIAM RUSSIN; Fiscal Year: 2007
    ..of aqueous humor outflow, 5) the role of BRCA2 and centrobin in the regulation of centrosome duplication in cultured tumor cells, and 6) ADDL-induced synaptic spine changes in primary hippocampal cultures...
  11. QB CYTOLOGY, METHOD FOR DETECT CIRCULATING CANCER CELLS
    David Rimm; Fiscal Year: 2000
    ..of the separations, in pilot studies with high power examination of the tubes we have shown that single cultured tumor cells can be identified microscopically by both morphology and epitopic markers...
  12. Phase 2 Study of PTC299 in Glioblastoma Multiforme (IND 71,033)
    JAY A BARTH; Fiscal Year: 2010
    ..In vitro studies in cultured tumor cells demonstrate that PTC299 impairs VEGF production in multiple tumor types...
  13. PET Radiotracers to Evaluate Tumor Multidrug Resistance
    Mark Green; Fiscal Year: 2006
    ..Tracer screening itz vitro will employ cultured tumor cells for assessment of agent selectivity for drug-sensitive vs...
  14. TUMOR IMAGING WITH NUCLIDES THAT BIND TO METALLOTHIONEIN
    Kathryn Morton; Fiscal Year: 1993
    ..measure MT content and uptake of Cd-109 in tumors grown in mice from a wide variety of histologic types of cultured tumor cells. To determine if MT-enrichment in tumors alone is sufficient to result in the concentration in tumors of MT-..
  15. PHASE I CLINICAL TRIAL WITH MONOCLONAL ANTI-IDIOTYPE
    Dorothee Herlyn; Fiscal Year: 1991
    ..cells, patients' peripheral blood lymphocytes will be stimulated in culture with Ab2, antigen or autologous cultured tumor cells followed by testing of proliferative response and cytolytic activities of the stimulated cells...
  16. RAPID PRODUCTION OF TUMOR SPECIFIC HYBRIDOMAS
    ANDREW TOMETSKO; Fiscal Year: 1991
    ..Phase I study will demonstrate the feasibility of using both soluble protein antigens as well as cultured tumor cells in conjunction with this accelerated immunization technique...
  17. Calcitonin in Prostate Growth and Neoplasia
    Girish Shah; Fiscal Year: 2008
    ..abstract_text> ..
  18. Examination of FLT3 Mutations in Acute Myeloid Leukemia
    Derek Stirewalt; Fiscal Year: 2006
    ..Together, the research proposal and educational program provide Dc Stirewalt with the skills to become an independent clinical investigator. ..
  19. Phase II Clinical Trial Utilizing Lithium for Patients with Neuroendocrine Tumors
    Herbert Chen; Fiscal Year: 2008
    ..Besides surgery, there are limited curative and palliative treatments available to patients with metastatic NE tumors, emphasizing the need for development of other forms of therapy. [unreadable] [unreadable] [unreadable]..
  20. DETERMINANTS OF TISSUE ESTRADIOL SENSITIVITY
    Richard Santen; Fiscal Year: 2009
    ..FTS, a novel mTOR inhibitor will be used in vitro to activate the stress kinase pathway and apoptosis. In vivo, FTS will be used to enhance estradiol induced apoptosis in nude mice. ..
  21. HU/JHU Head and Neck Cancer Translational Research and *
    Xinbin Gu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  22. Radioimmunotherapy of CD20+ Lymphomas & CD45+Leukemias
    JOHN PAGEL; Fiscal Year: 2008
    ..abstract_text> ..
  23. Modifying Genes in Pulmonary Hypertension
    Ari Zaiman; Fiscal Year: 2008
    ..unreadable]..
  24. RED CELL CYTOSKELETAL PROTEIN AND MITOSIS
    Shu Ching Huang; Fiscal Year: 2008
    ..Finally, we shall define the relationship between changes in the expression of these 4.1R isoforms and the transition from proliferation to post-mitotic states during erythroid differentiation. ..
  25. Endocannabinoid Analogs as Anti-inflammatory Agents
    Sumner Burstein; Fiscal Year: 2008
    ..Thus, agents such as NAGly that can regulate in vivo anandamide levels could be effective modulators of many of these health related processes. ..
  26. NON PSYCHOACTIVE CANNABINOIDS WITH THERAPEUTIC POTENTIAL
    Sumner Burstein; Fiscal Year: 2002
    ..abstract_text> ..
  27. Targeting Tumor Angiogenesis with G-Quadruplex Binders
    Daekyu Sun; Fiscal Year: 2010
    ..abstract_text> ..
  28. Iron Acquisition Mechanisms in Oligodendrocytes
    JAMES ROBERT CONNOR; Fiscal Year: 2010
    ..abstract_text> ..
  29. Mechanisms of immunomodulatory and anti-tumor actions of Polysaccharide Krestin
    Mary L Disis; Fiscal Year: 2010
    ..Results from these studies will help us understand the immune modulating effect of PSK and contribute to the clinical translation of this CAM molecule as an anti-cancer agent and/or a vaccine adjuvant. ..
  30. Mitochondria and Carcinogenesis
    Keshav K Singh; Fiscal Year: 2010
    ..The proposed study will help determine the contribution of mutant mtDNA to the development of human cancer. ..
  31. Regulating Neuroendocrine Phenotype in Cancer
    Herbert Chen; Fiscal Year: 2010
    ..Furthermore, these finding may permit development of components of raf-1 pathway as therapeutic targets in the treatment and palliation of NE tumors. ..
  32. Roles of polymorphic COMT, tea polyphenols and proteasome in cancer prevention
    QING PING DOU; Fiscal Year: 2010
    ..abstract_text> ..
  33. Mitochondria and Mutagenesis
    Keshav K Singh; Fiscal Year: 2010
    ..abstract_text> ..
  34. Bispecific Antibody Pretargeted Therapy of Pancreatic Cancer
    ROBERT SHARKEY; Fiscal Year: 2008
    ..Overall, these studies will assist in establishing whether this type of pretargeting approach could have a role in the clinical management of pancreatic cancer. [unreadable] [unreadable] [unreadable]..
  35. Subharmonic Microbubble Signals for Pressure Estimation
    Flemming Forsberg; Fiscal Year: 2008
    ..This will allow potentially life-threatening diseases, such as increased pressure in the liver, to be diagnosed early. [unreadable] [unreadable] [unreadable]..
  36. Conference on Photodynamic Therapy
    David Kessel; Fiscal Year: 2002
    ..The most recent PDT meeting, sponsored by the International Photodynamic Assn, has more than 600 participants. ..
  37. Isolation and Characterization of a Ferritin Receptor
    James Connor; Fiscal Year: 2005
    ..This project will significantly alter our thinking on brain iron transport and open novel directions for research in oligodendrocyte biology and diagnositic and therapeutic strategies in demyelinating disorders ..
  38. REGULATION OF MACROPHAGE INOS EXPRESSION
    Ming hai Wang; Fiscal Year: 2001
    ..Second it will facilitate understanding of the role of MSP in regulating macrophage activities in inflammation. Further, this work may lead to novel approaches for decreasing tissue destruction in inflammation. ..
  39. Progestin Regulation of VEGF in Breast Cancer Cells
    SALMAN HYDER; Fiscal Year: 2005
    ..abstract_text> ..
  40. CHARACTERIZATION OF AN INVASIVE HUMAN PROSTATE CANCER
    Haiyen Zhau; Fiscal Year: 2004
    ..The ARCaP model may allow definition of the molecular basis of prostate cancer progression to androgen independence and expression of invasive and bone-homing phenotypes. ..
  41. MITDNA MUTAGENESIS BY ENVIRONMENTAL CARCINOGENS
    Keshav Singh; Fiscal Year: 2003
    ..The proposed study will fill a major gap in our understanding of the mechanisms of mitDNA mutagenesis induced by environmental carcinogens which has direct relevance in on the induction of mitochondrial diseases. ..
  42. Development of Novel Fluorinated Amino Acids
    Mark Goodman; Fiscal Year: 2004
    ..abstract_text> ..
  43. ANTITUMOR IMMUNITY INDUCED BY FUSION CELLS VACCINATION
    Jianlin Gong; Fiscal Year: 2003
    ..3). To assess the effectiveness of fusion cell vaccines in the prevention and treatment of spontaneous breast carcinoma in transgenic mice. ..
  44. Improved Detection of Cancer Using Bi Specific Antibody
    ROBERT SHARKEY; Fiscal Year: 2003
    ....
  45. Mechanism of Thimerosal Induced Neurotoxicity
    KINSLEY KININGHAM; Fiscal Year: 2003
    ..This project will generate mechanistic data on thimerosal neurotoxicity and potentially identify specific targets for pharmacological intervention. ..
  46. TEA TARGETING PROTEASOME--A ROLE IN CANCER PREVENTION
    QING DOU; Fiscal Year: 2002
    ..A Future Aim is to determine whether in vivo proteasome-inhibitory ability of tea polyphenols is related to their antitumor activity using nude mice bearing human prostate tumors. ..
  47. RAIT of Pancreatic Cancer with Humanized PAM4
    ROBERT SHARKEY; Fiscal Year: 2005
    ..The trial will be conducted at the Garden State Cancer Center and Johns Hopkins University School of Medicine. CMMI will be responsible for monitoring the study's progress. ..
  48. CELL/MOLECULAR BIOLOGY LEARNING AND CURRICULUM CENTER
    Roland Nardone; Fiscal Year: 2005
    ..C. Public School System. This program provides hands-on experience using methods and equipment not ordinarily available to the teachers and students. ..
  49. MAb-based targeted chemotherapy of lung cancer
    Serengulam Govindan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  50. GENE THERAPY FOR HUMAN MALIGNANT MELANOMA
    Elizabeth Grimm; Fiscal Year: 2006
    ..abstract_text> ..
  51. ISOLATION OF THE NEUROBLASTOMA PREDISPOSITION GENE
    John Maris; Fiscal Year: 2006
    ..Ultimately, these experiments should lead to the identification of a common pathway to neuroblastoma tumorigenesis that will be an outstanding target for rationally designed therapeutics. ..
  52. Planning Grant for Institutional Clinical and Translational Science Award
    MARY DISIS; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  53. Phase I Trial of a HER2 ICD Plasmid-Based DNA Vaccine
    MARY DISIS; Fiscal Year: 2007
    ..The long-term goal will be to use this study as a platform to develop multi-antigen plasmid based vaccines for the prevention of common solid tumors. ..
  54. Biochemistry of Antigen Presentation Mechanisms
    Brian Cobb; Fiscal Year: 2007
    ..From this point of view, the proposed studies represent the culmination of my educational goals as a biochemistry graduate student and a fellow studying immunology and pathogenesis. [unreadable] [unreadable]..
  55. Development and Applications of Novel SERT PET Ligands
    Mark Goodman; Fiscal Year: 2006
    ..Once SERT binding is determined in depressed patients, we will be able to assess the relationship of SERT binding and treatment response to SSRIs. ..
  56. Heterogeneity of Human Melanoma, Cytokines and iNOS
    Elizabeth Grimm; Fiscal Year: 2006
    ..Therefore, the analysis of INOS and the functional, molecular, and prognostic consequences of iNOS expression are proposed for critical evaluation in this application. ..
  57. Immunologic Correlates of Immunization for Cancer
    MARY DISIS; Fiscal Year: 2006
    ..abstract_text> ..
  58. The Proteasome as Molecular Target of Grape Polyphenols
    QING PING DOU; Fiscal Year: 2005
    ..abstract_text> ..
  59. A High-Throughput Screen to Identify Small Molecule Compounds That Augment
    Brent Passer; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  60. Silibinin in Prostate Cancer Chemoprevention & Treatment
    Michael Pollak; Fiscal Year: 2004
    ..The work is justified by the favorable toxicity profile of silibinin, together with prior positive laboratory studies reported by our group and other investigators. ..
  61. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    HECTOR MOBINE; Fiscal Year: 2008
    ..The findings may not only afford further appreciation of the pathophysiology and etiology of peripartum cardiomyopathy but also of general mechanisms in disease progression. [unreadable] [unreadable] [unreadable]..