Genomes and Genes
Summary: A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Publications302 found, 100 shown here
- Heterogeneity in cancer: cancer stem cells versus clonal evolutionMark Shackleton
Howard Hughes Medical Institute, Life Sciences Institute, Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI 48109, USA
Cell 138:822-9. 2009....
- Characterization of clonogenic multiple myeloma cellsWilliam Matsui
Sidney Kimmel Comprehensive Cancer Center, John Hopkins University School of Medicine, Bunting Blaustein Cancer Research Bldg, Rm 245, 1650 Orleans St, Baltimore, MD 21231, USA
Blood 103:2332-6. 2004..These data suggest that MM "stem cells" are CD138- B cells with the ability to replicate and subsequently differentiate into malignant CD138+ plasma cells...
- Transcriptome-wide noise controls lineage choice in mammalian progenitor cellsHannah H Chang
Vascular Biology Programme, Department of Pathology and Surgery, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 453:544-7. 2008....
- Mouse germ line stem cells undergo rapid and stochastic turnoverAllon M Klein
Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Cell Stem Cell 7:214-24. 2010..These results suggest that short-lived stem cells may be a common feature of mammalian stem cell systems and reveal a natural mechanism for matching the rates of cell proliferation and loss in tissue...
- HIV-1 integration in the human genome favors active genes and local hotspotsAstrid R W Schroder
Infectious Disease Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell 110:521-9. 2002..4 kb region containing 1% of sites. These data document unexpectedly strong biases in integration site selection and suggest how selective targeting promotes aggressive HIV replication...
- Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytesMark E Dudley
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20902, USA
Science 298:850-4. 2002..This approach presents new possibilities for the treatment of patients with cancer as well as patients with human immunodeficiency virus-related acquired immunodeficiency syndrome and other infectious diseases...
- Viable offspring derived from fetal and adult mammalian cellsI Wilmut
Roslin Institute Edinburgh, Roslin, Midlothian, UK
Nature 385:810-3. 1997....
- Control of compartment development by the engrailed gene in DrosophilaG Morata
Nature 255:614-7. 1975
- The hematopoietic stem compartment consists of a limited number of discrete stem cell subsetsHans B Sieburg
Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92112, USA
Blood 107:2311-6. 2006..These data from the steady-state HSC repertoire could provide a basis for the diagnosis of perturbed patterns of HSCs potentially caused by disease or aging...
- Human T-cell memory consists mainly of unexpanded clonesPaul L Klarenbeek
Department of Clinical Immunology and Rheumatology, AMC University of Amsterdam, The Netherlands
Immunol Lett 133:42-8. 2010..It raises new questions on the factors that steer maturation of memory phenotype and determine the size of memory clones...
- Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA virusesDavid A Price
Human Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 202:1349-61. 2005..Vaccine strategies that reconstruct these biological processes could generate T cell populations that mediate optimal delivery of antiviral effector function...
- Cellular barcoding tool for clonal analysis in the hematopoietic systemAlice Gerrits
Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Blood 115:2610-8. 2010..This cellular barcoding tool permits a simple, sensitive assessment of clonality and holds great promise for future gene therapy protocols in humans, and any other applications when clonal tracking is important...
- Development of mesenchymal stem cells partially originate from the neural crestSatoru Morikawa
Department of Physiology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
Biochem Biophys Res Commun 379:1114-9. 2009..Our results suggest that MSCs in adult bone marrow have at least two developmental origins, one of which is the neural crest...
- Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencingPeter J Campbell
Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom
Proc Natl Acad Sci U S A 105:13081-6. 2008..This study demonstrates the potential for ultra-deep resequencing to recapitulate the dynamics of clonal evolution in cancer cell populations...
- A single type of progenitor cell maintains normal epidermisElizabeth Clayton
MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge CB2 0XZ, UK
Nature 446:185-9. 2007..These cells are found to undergo both symmetric and asymmetric division at rates that ensure epidermal homeostasis. The results raise important questions about the potential role of stem cells on tissue maintenance in vivo...
- Scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of CrumbsGregory R Leong
Peter MacCallum Cancer Centre, Victoria, Australia
BMC Biol 7:62. 2009..Increasing evidence also implicates the loss of human Scrib in cancer. In this report, we investigate how loss of Scrib promotes epithelial tumourigenesis in Drosophila, both alone and in cooperation with oncogenic mutations...
- Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasmsFranz X Schaub
Department of Biomedicine, Experimental Hematology, University Hospital Basel, Hebelstr 20, 4031 Basel, Switzerland
Blood 115:2003-7. 2010..The lack of a strict temporal order of occurrence makes it unlikely that mutations in TET2 represent a predisposing event for acquiring mutations in JAK2...
- Persistent survival of prevalent clonotypes within an immunodominant HIV gag-specific CD8+ T cell responseDavid J van Bockel
St Vincent s Centre for Applied Medical Research, University of New South Wales, Sydney, New South Wales, Australia
J Immunol 186:359-71. 2011....
- Establishment and maintenance of planar epithelial cell polarity by asymmetric cadherin bridges: a computer modelJean François Le Garrec
Modélisation Dynamique des Systèmes Biologiques Intégrés, CNRS UMR 7138 Systématique, Adaptation, Evolution, Universite Pierre et Marie Curie, Paris, France
Dev Dyn 235:235-46. 2006..These features, largely independent of model details, may provide useful clues for future experimental efforts...
- Selective growth, in vitro and in vivo, of individual T cell clones from tumor-infiltrating lymphocytes obtained from patients with melanomaJuhua Zhou
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 173:7622-9. 2004..A similar analysis may also be useful for monitoring autoimmune responses...
- Energetic heavy ions accelerate differentiation in the descendants of irradiated normal human diploid fibroblastsNobuyuki Hamada
Department of Quantum Biology, Division of Bioregulatory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
Mutat Res 637:190-6. 2008..Accelerated differentiation may account, at least in part, for dose- and LET-dependent delayed loss of clonogenicity in normal human diploid cells, and could be a defensive mechanism that minimizes further expansion of aberrant cells...
- Identification of human oral keratinocyte stem/progenitor cells by neurotrophin receptor p75 and the role of neurotrophin/p75 signalingTakahiro Nakamura
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 0841, Japan
Stem Cells 25:628-38. 2007..Our in vivo and in vitro findings indicate that p75 is a potential marker of oral keratinocyte stem/progenitor cells and that some neurotrophin/p75 signaling affects cell growth and survival...
- Inflamed target tissue provides a specific niche for highly expanded T-cell clones in early human autoimmune diseaseP L Klarenbeek
Department of Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
Ann Rheum Dis 71:1088-93. 2012....
- The HLA A*0201-restricted hTERT(540-548) peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptorMarco A Purbhoo
Avidex Ltd, 57 59 Milton Park, Abingdon, OX14 4RX, United Kingdom
Mol Cancer Ther 6:2081-91. 2007..We propose that, in future, rigorous methods must be applied for the validation of peptide epitopes used for clinical applications...
- Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia veraAnn Mullally
Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Blood 120:166-72. 2012..These findings recapitulate the development of post-PV myelofibrosis in human myeloproliferative neoplasms. In aggregate, these results demonstrate the distinct roles of LT-HSCs and erythroid precursors in the pathogenesis of PV...
- Reconstruction of rat retinal progenitor cell lineages in vitro reveals a surprising degree of stochasticity in cell fate decisionsFrancisco L A F Gomes
Cellular Neurobiology Research Unit, Institut de Recherches Cliniques de Montreal, Montreal, QC H2W 1R7, Canada
Development 138:227-35. 2011....
- Core-specific adaptive regulatory T-cells in different outcomes of hepatitis CBettina Langhans
Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Clin Sci (Lond) 119:97-109. 2010..Thus HCV core-specific Treg-cells may contribute to the immunoregulatory balance in chronic hepatitis C...
- CMV-specific TCR-transgenic T cells for immunotherapyAndrea Schub
Department of Gene Vectors, Helmholtz Zentrum Munchen, Munich, Germany
J Immunol 183:6819-30. 2009..Hence, we expect these CMV-TCR-transgenic T cells to be effective in controlling acute CMV disease and establishing an antiviral memory...
- Phenotypic and functional characterization of CD4 T cells expressing killer Ig-like receptorsJeroen van Bergen
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
J Immunol 173:6719-26. 2004..Together, our data indicate that KIR-expressing CD4 T cells are predominantly HLA class II-restricted effector memory Th1 cells, and that a significant, previously unrecognized fraction of effector memory Th1 cells expresses KIR...
- Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletionC Bouneaud
Unité de Biologie Moléculaire du Gène, INSERM U277, Institut Pasteur, Paris, France
Immunity 13:829-40. 2000..These results suggest that numerous low-affinity self-specific T cells persist in the periphery and show that a deleting ligand can specifically narrow the structural diversity of the TCR repertoire...
- Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesisAnthony M Brumby
Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
Genetics 188:105-25. 2011..Collectively our analysis reveals the importance of the RhoGEF/Rho-family/JNK pathway in cooperative tumorigenesis with Ras(ACT)...
- Trafficking, persistence, and activation state of adoptively transferred allogeneic and autologous Simian Immunodeficiency Virus-specific CD8(+) T cell clones during acute and chronic infection of rhesus macaquesDiane L Bolton
Immunotechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 184:303-14. 2010..The lack of impact following transfer of such a large number of functional Ag-specific CD8(+) T cells on SIV replication may reflect the magnitude of the immune response required to contain the virus...
- Clonogenic growth of epithelial cells from normal colonic mucosa from both mice and humansR H Whitehead
Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Melbourne, Australia
Gastroenterology 117:858-65. 1999..The factors controlling the proliferation and differentiation of the colonic mucosa are unknown and have proved difficult to identify mainly because of a lack of in vitro methods for studying the proliferative cells of the mucosa...
- Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genesS L Mansour
Howard Hughes Medical Institute, Department of Biology, University of Utah, Salt Lake City 84112
Nature 336:348-52. 1988..The procedure was applied to the isolation of hprt- and int-2- mutants, but it should be applicable to any gene...
- Multiple HLA class II-restricted melanocyte differentiation antigens are recognized by tumor-infiltrating lymphocytes from a patient with melanomaPaul F Robbins
Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B42, Bethesda, MD 20892 7502, USA
J Immunol 169:6036-47. 2002..These observations provide an impetus to develop strategies directed toward generating HLA class II-restricted tumor-reactive T cells...
- A comprehensive survey of clonal diversity measures in Barrett's esophagus as biomarkers of progression to esophageal adenocarcinomaLauren M F Merlo
Molecular and Cellular Oncogenesis Program, The Wistar Institute, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania19104, USA
Cancer Prev Res (Phila) 3:1388-97. 2010..001). The type of alterations evaluated had little effect on the predictive value of most of the diversity measures. In summary, diversity measures are robust predictors of progression to cancer in this cohort...
- Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrowSatoru Morikawa
Department of Physiology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
J Exp Med 206:2483-96. 2009..Naive MSCs resided in the perivascular region in a quiescent state. This study provides the useful method needed to identify MSCs as defined in vivo entities...
- Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesisFeng Ma
Division of Cellular Therapy, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
Proc Natl Acad Sci U S A 105:13087-92. 2008..The present study should provide an experimental model for exploring early development of human erythropoiesis and hemoglobin switching and may help in the discovery of drugs for hereditary diseases in erythrocyte development...
- A unique three-dimensional model for evaluating the impact of therapy on multiple myelomaJulia Kirshner
Department of Oncology, University of Alberta and Cross Cancer Institute, Edmonton, AB, Canada
Blood 112:2935-45. 2008..The 3-D culture provides a novel biologically relevant preclinical model for evaluating therapeutic vulnerabilities of all compartments of the MM clone, including presumptive drug-resistant MM stem cells...
- Characterization of murine JAK2V617F-positive myeloproliferative diseaseThomas G P Bumm
Center for Hematologic Malignancies, Oregon Health and Science University Cancer Institute, Portland, OR 97239, USA
Cancer Res 66:11156-65. 2006..The disease was not transplantable and prolonged observation showed normalization of blood counts in most JAK2(V617F) mice, suggesting that the mutation may not confer self-renewal capacity...
- Extrusion of cells with inappropriate Dpp signaling from Drosophila wing disc epitheliaJie Shen
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Science 307:1789-90. 2005..This loss correlates with extensive cytoskeletal changes followed by basal epithelial extrusion. We propose that Dpp promotes cell survival within disc epithelia by affecting cytoskeletal organization...
- Type 1 T regulatory cellsM G Roncarolo
San Raffaele Telethon Institute of Gene Therapy HSR TIGET, San Raffaele Scientific Institute, Milan, Italy
Immunol Rev 182:68-79. 2001..The use of Tr1 cells to identify novel targets for the development of new therapeutic agents, and as a cellular therapy to modulate peripheral tolerance, can be foreseen...
- Coordination of growth and cell division in the Drosophila wingT P Neufeld
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cell 93:1183-93. 1998..We infer that dE2F and RBF function specifically in cell cycle control, and that cell cycle acceleration is insufficient to stimulate growth. Variations in dE2F activity could be used to coordinate cell division with growth...
- Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversitySuzanne Bixby
Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
Neuron 35:643-56. 2002..Upon transplantation of uncultured NCSCs into developing peripheral nerves in vivo, sciatic nerve NCSCs gave rise only to glia, while gut NCSCs gave rise primarily to neurons. Thus, cell fate in the nerve was stem cell determined...
- Leukemic B cells clonally identical to myeloma plasma cells are myelomagenic in NOD/SCID miceLinda M Pilarski
Department of Oncology, University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada
Exp Hematol 30:221-8. 2002....
- An episomal mammalian replicon: sequence-independent binding of the origin recognition complexDaniel Schaarschmidt
Department of Biology, Universitat Konstanz, Konstanz, Germany
EMBO J 23:191-201. 2004..It indicates that specific DNA sequences are not required for the chromatin binding of ORC in vivo. The conclusion is that epigenetic mechanisms determine the sites where mammalian DNA replication is initiated...
- Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemiaNeil P Shah
Department of Medicine, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Cancer Cell 2:117-25. 2002..Multiple independent mutant clones were detected in a subset of relapsed cases. Our data support a clonal selection model of preexisting BCR-ABL mutations that confer imatinib resistance...
- Propagation, expansion, and multilineage differentiation of human somatic stem cells from dermal progenitorsGeorg Bartsch
Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Stem Cells Dev 14:337-48. 2005..Clonal growth of MSCs presents profound implications in our understanding of differentiation and development, and should provide a valuable resource for tissue repair...
- In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrainC M Morshead
Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Development 125:2251-61. 1998..There were calculated to be 1200-1300 cells between the rostral corpus callosum and rostral anterior commissure; these data support a lineage model similar to those based on stem cell behavior in other tissue types...
- Actin-myosin contractility is responsible for the reduced viability of dissociated human embryonic stem cellsGuokai Chen
Morgridge Institute for Research, Madison, WI 53707 7365, USA
Cell Stem Cell 7:240-8. 2010..ROCK inhibition decreases phosphorylation of myosin light chain, suggesting that inhibition of actin-myosin contraction is also the mechanism through which ROCK inhibitors increase cloning efficiency of human ESCs...
- Generation of pluripotent stem cells from adult mouse liver and stomach cellsTakashi Aoi
Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
Science 321:699-702. 2008..These data suggest that iPS cells are generated by direct reprogramming of lineage-committed somatic cells and that retroviral integration into specific sites is not required...
- Dangerous small B-cell clonesGiampaolo Merlini
Amyloid Center, Biotechnology Research Laboratories, Foundation IRCCS Policlinico San Matteo, Piazzale Golgi 2, 27100 Pavia, Italy
Blood 108:2520-30. 2006..Although the treatment of these conditions is not optimal, significant advances have been made, improving the duration and quality of life...
- The clonal origin of myocardial cells in different regions of the embryonic mouse heartSigolène M Meilhac
CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
Dev Cell 6:685-98. 2004..These results are not consistent with the prespecification of the cardiac tube as a segmented structure. They are discussed in the context of different heart fields and of the evolution of the heart...
- The clonal evolution of metastases from primary serous epithelial ovarian cancersLalarukh Khalique
Gynaecological Cancer Research Laboratories, UCL EGA Institute for Women s Health, University College London, London, UK
Int J Cancer 124:1579-86. 2009....
- Alkaline phosphatase-positive colony formation is a sensitive, specific, and quantitative indicator of undifferentiated human embryonic stem cellsMichael D O'Connor
Terry Fox Laboratory, 675 West 10th Avenue, Vancouver, British Columbia, Canada V5Z 1L3
Stem Cells 26:1109-16. 2008..Its use under standardized assay conditions should enhance future elucidation of the mechanisms that regulate hESC propagation and their early differentiation...
- Genetic diversity and geographical dispersal in grapevine clones revealed by microsatellite markersXimena Moncada
Laboratorio de Biotecnologia, Centro de Investigación La Platina, Instituto de Investigaciones Agropecuarias, INIA, Chile, PO Box 439 3 Santiago, Chile
Genome 49:1459-72. 2006..The possibility that this kind of genetic variability occurs in other vegetatively propagated species is discussed, focusing on possible fingerprinting applications...
- Timing neurogenesis and differentiation: insights from quantitative clonal analyses of cerebellar granule cellsJ Sebastian Espinosa
Howard Hughes Medical Institute and Department of Biology, Neurosciences Program, Stanford University, Stanford, California 94305, USA
J Neurosci 28:2301-12. 2008..These properties produce GC clones that are distinct, each having a restricted axonal projection, but that are on average similar in cell number. We discuss possible developmental mechanisms and functional implications of these findings...
- Recurrence of autoreactive antigen-specific CD4+ T cells in autoimmune diabetes after pancreas transplantationElsa Laughlin
Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA
Clin Immunol 128:23-30. 2008..Comparisons of TCR clonotypes by cDNA sequencing revealed that identical T cells were present in the circulation, separated by long time intervals, consistent with a persistent memory response associated with recurrent autoimmunity...
- Multipotent cells can be generated in vitro from several adult human organs (heart, liver, and bone marrow)Antonio P Beltrami
Centro Interdipartimentale Medicina Rigenerativa, University of Udine, Piazzale Santa Maria della Misericordia, 33100 Udine, Italy
Blood 110:3438-46. 2007....
- The narrowing of the CD8 T cell repertoire in old ageMarcia A Blackman
Trudeau Institute, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
Curr Opin Immunol 23:537-42. 2011....
- Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarityTomoyuki Yamanaka
Department of Molecular Biology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Japan
Curr Biol 13:734-43. 2003..However, how physically separated proteins interact remains to be clarified...
- Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in DrosophilaShizue Ohsawa
Division of Genetics, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
Nature 490:547-51. 2012..Our findings provide a mechanistic basis for interclonal tumour progression driven by mitochondrial dysfunction and oncogenic Ras...
- Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformationPeter J Campbell
Department of Haematology, University of Cambridge, Cambridge, United Kingdom
Blood 108:3548-55. 2006..In 3 patients the leukemic cells were V617F(-), suggesting that in these patients the leukemia arose in a V617F(-) cell...
- WT1 mutations in T-ALLValeria Tosello
Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
Blood 114:1038-45. 2009..Survival analysis demonstrated that WT1 mutations do not confer adverse prognosis in pediatric and adult T-ALL. Overall, these results identify the presence of WT1 mutations as a recurrent genetic alteration in T-ALL...
- Deciphering the mammary epithelial cell hierarchyJohn Stingl
Department of Pathology, University of Cambridge, Cambridge, UK
Cell Cycle 5:1519-22. 2006..Suggestive parallels between mouse and human mammary cells point to the likelihood that a similarly structured multi-step differentiation program characterizes the mammary gland from both species...
- Two compensatory pathways maintain long-term stability and diversity in CD8 T cell memory repertoiresElena N Naumova
Department of Public Health and Family Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
J Immunol 183:2851-8. 2009..The recruitment of new clonotypes into the low-frequency component of the repertoire implies a role for these clonotypes...
- Single cell analysis reveals similar functional competence of dominant and nondominant CD8 T-cell clonotypesDaniel E Speiser
Ludwig Center for Cancer Research, University of Lausanne, Lausanne CH 1011, Switzerland
Proc Natl Acad Sci U S A 108:15318-23. 2011..In parallel, this was also found for EBV- and CMV-specific T cells. Thus, the nondominant clonotypes may contribute similarly to immunity as their dominant counterparts...
- RGB marking facilitates multicolor clonal cell trackingKristoffer Weber
Research Department Cell and Gene Therapy, Clinic for Stem Cell Transplantation, University Cancer Center Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Nat Med 17:504-9. 2011..We conclude that RGB marking represents a useful tool for cell clonality studies in tissue regeneration and pathology...
- Ultra-sensitive detection of rare T cell clonesHarlan Robins
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States
J Immunol Methods 375:14-9. 2012..The precision of the assay is demonstrated across five orders of magnitude. The accuracy for each clone is within an overall factor of three across the 100,000 fold dynamic range. Additionally, the assay is shown to be highly repeatable...
- Heterogeneity of anticancer drug sensitivity in squamous cell carcinoma of the tongueMinako Suzuki
Oral and Maxillofacial Surgery and Systemic Medicine, Graduate School of Life Dentistry at Niigata, The Nippon Dental University, Niigata, Japan
Hum Cell 24:21-9. 2011..After examining anticancer drug sensitivity at the single cell level, we believe that anticancer drug-resistant genes may be involved in the heterogeneity of anticancer drug sensitivity with respect to cancer cell groups...
- Tob is a negative regulator of activation that is expressed in anergic and quiescent T cellsD Tzachanis
Department of Adult Oncology, Dana Farber Cancer Institute, Division of Medical Oncology, Harvard Medical School, Boston, MA 02115, USA
Nat Immunol 2:1174-82. 2001..Thus, T cell quiescence is an actively maintained phenotype that must be suppressed for T cell activation to occur...
- Comparative clonal analysis of reconstitution kinetics after transplantation of hematopoietic stem cells gene marked with a lentiviral SIN or a γ-retroviral LTR vectorKerstin Cornils
Research Department Cell and Gene Therapy, Clinic for Stem Cell Transplantation, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
Exp Hematol 41:28-38.e3. 2013..Finally, our results confirm the notion that marking with lentiviral self-inactivating vectors is associated with a lower risk of genotoxicity as compared with γ-retroviral LTR vectors...
- Counting stem cells: methodological constraintsLeonid V Bystrykh
Laboratory of Stem Cell Research, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, The Netherlands
Nat Methods 9:567-74. 2012..We discuss how restriction enzyme choice, PCR bias, high-throughput sequencing depth and tagging method could affect the conclusions of clonal studies...
- Epstein-Barr nuclear antigen 1-specific CD4(+) Th1 cells kill Burkitt's lymphoma cellsCasper Paludan
Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
J Immunol 169:1593-603. 2002..Therefore, adaptive immunity can be directed against Burkitt's lymphoma, and perhaps this role for CD4(+) Th1 cells extends to other tumors that escape MHC class I presentation...
- HIV-specific CD8+ T cells from HIV+ individuals receiving HAART can be expanded ex vivo to augment systemic and mucosal immunity in vivoAude G Chapuis
Program in Immunology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
Blood 117:5391-402. 2011....
- How to improve the success rate of mouse cloning technologyNguyen Van Thuan
Department of Animal Bioscience and Biotechnology, Konkuk University, South Korea
J Reprod Dev 56:20-30. 2010..This review describes how to improve the efficiency of cloning, the establishment of clone-derived embryonic stem cells and further applications...
- Chromosomal alterations cause the high rates and wide ranges of drug resistance in cancer cellsRuhong Li
Department of Molecular and Cell Biology, Donner Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA
Cancer Genet Cytogenet 163:44-56. 2005..The degree of resistance was roughly proportional to the number of these aneusomies. Thus, aneuploidy is the primary cause of the high rates and wide ranges of drug resistance in cancer cells...
- Alpha 3 domain mutants of peptide/MHC class I multimers allow the selective isolation of high avidity tumor-reactive CD8 T cellsMikael J Pittet
Division of Clinical Onco Immunology, Ludwig Institute for Cancer Research, University Hospital, Lausanne, Switzerland
J Immunol 171:1844-9. 2003..Our results are relevant for ex vivo identification and isolation of T cells with potent antitumor activity for adoptive T cell therapy...
- Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cellsPaola Bonfanti
Laboratory of Stem Cell Dynamics, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
Nature 466:978-82. 2010..Hence, microenvironmental cues are sufficient here to re-direct epithelial cell fate, allowing crossing of primitive germ layer boundaries and an increase in potency...
- Persistence of multiple tumor-specific T-cell clones is associated with complete tumor regression in a melanoma patient receiving adoptive cell transfer therapyJuhua Zhou
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunother 28:53-62. 2005....
- Methicillin-resistant coagulase-negative staphylococci in the community: high homology of SCCmec IVa between Staphylococcus epidermidis and major clones of methicillin-resistant Staphylococcus aureusFrancois Barbier
Bacteriology Unit and National Reference Center for Emergence of Resistance in Commensal Flora, 2EA 3964, Bichat Claude Bernard Hospital, Assistance Publique Hôpitaux de Paris and Xavier Bichat Medical School, Denis Diderot Paris 7 University, Paris, France
J Infect Dis 202:270-81. 2010..We assessed their potential role as a reservoir of staphylococcal cassette chromosome mec (SCCmec) IVa, the leading SCCmec subtype in community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA)...
- Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterizationSylvain Brisse
Institut Pasteur, Genotyping of Pathogens and Public Health, Paris, France
PLoS ONE 4:e4982. 2009..pneumoniae...
- On the karyotypic origin and evolution of cancer cellsJoshua M Nicholson
Department of Molecular and Cell Biology, Donner Laboratory, University of California Berkeley, Berkeley, CA 94720, USA
Cancer Genet Cytogenet 194:96-110. 2009..In sum, genomes consisting of individual and flexible karyotypes explain the characteristic individuality, stability, and flexibility of cancers...
- Clonal variation in phenotype and life span of human embryonic fibroblasts (MRC-5) transduced with the catalytic component of telomerase (hTERT)S Franco
Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Exp Cell Res 268:14-25. 2001..In addition, fibroblast-specific biological parameters, such as colony size, production of collagenase, and response to MMC and gamma radiation were tightly regulated at the clonal and subclonal levels...
- Human natural killer cells with polyclonal lectin and immunoglobulinlike receptors develop from single hematopoietic stem cells with preferential expression of NKG2A and KIR2DL2/L3/S2J S Miller
Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota Cancer Center, Harvard Street at East River Road, Minneapolis, MN 55455, USA
Blood 98:705-13. 2001..Blood. 2001;98:705-713)..
- Chromosomal aberrations are shared by malignant plasma cells and a small fraction of circulating CD19+ cells in patients with myeloma and monoclonal gammopathy of undetermined significanceNiklas Zojer
First Department of Internal Medicine and Medical Oncology, Wilhelminenspital, University of Vienna, Montleartstrasse 37, 1160 Vienna, Austria
Br J Haematol 117:852-9. 2002..These results provide evidence that the circulating clonotypic B cells are closely related to the malignant plasma cells in myeloma and MGUS...
- The Drosophila mushroom body is a quadruple structure of clonal units each of which contains a virtually identical set of neurones and glial cellsK Ito
Yamamoto Behaviour Genes Project, ERATO Exploratory Research for Advanced Technology, JST Japan Science and Technology Corporation, at Mitsubishi Kasei Institute of Life Sciences, Minami Ooya, Tokyo, Japan
Development 124:761-71. 1997..Partial ablation of MBNbs using hydroxyurea showed that each of the four neuroblasts autonomously generates the entire repertoire of the known MB substructures...
- Insight into the origin and clonal history of B-cell tumors as revealed by analysis of immunoglobulin variable region genesF Stevenson
Tenovus Laboratory, Southampton University Hospitals Trust, UK
Immunol Rev 162:247-59. 1998..It also has a clear clinical relevance in tracking tumor cells, measuring residual disease, and finally in offering the opportunity of developing vaccines for treatment...
- Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacityKristin J Hope
Division of Cell and Molecular Biology, University Health Network, and Department of Molecular Genetics and Microbiology, University of Toronto, 620 University Avenue, Toronto, Ontario, M5G 2C1, Canada
Nat Immunol 5:738-43. 2004..Furthermore, normal developmental processes are not completely abolished during leukemogenesis. The existence of multiple stem cell classes shows the need for LSC-targeted therapies...
- Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936J J M van Dongen
Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Leukemia 17:2257-317. 2003..The BIOMED-2 multiplex tubes can now be used for diagnostic clonality studies as well as for the identification of PCR targets suitable for the detection of minimal residual disease...
- Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammationKaori Sakuishi
Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
J Immunol 179:3452-62. 2007..The iNKT cell subset producing IL-5 and IL-13 could play a major role in the development of allergic disease or asthma and also in the immune regulation of Th1 inflammation...
- Reproducible but dynamic positioning of DNA in chromosomes during mitosisS Dietzel
Department of Cell and Structural Biology, University of Illinois at Urbana-Champaign, 61801, USA
Nat Cell Biol 3:767-70. 2001..Unfolding intermediates during anaphase and telophase suggest that sequence repositioning occurs through the global uncoiling of an underlying chromatid structure...
- Self-renewal and solid tumor stem cellsMuhammad Al-Hajj
University of Michigan Medical School, CCGC Room 4410, 1500 E Medical Center Drive, Ann Arbor 48109 0936, USA
Oncogene 23:7274-82. 2004..This suggests that agents that target the defective self-renewal pathways in cancer cells might lead to improved outcomes in the treatment of these diseases...
- Memory inflation: continuous accumulation of antiviral CD8+ T cells over timeUrs Karrer
Nuffield Department of Clinical Medicine, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK
J Immunol 170:2022-9. 2003..This may be relevant for understanding the evolution of the large human CMV-specific CD8+ T cell populations seen in humans...
- Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell lineJing Wang
State Key Laboratory of Oncology in Southern China and Department of Experimental Research, Sun Yat sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510 060, P R China
Cancer Res 67:3716-24. 2007..Taken together, our data shed light on tumorigenesis and therapeutic-resistant mechanisms, which are helpful for developing novel targets for effective clinical treatment of NPC...
- High-avidity CTL exploit two complementary mechanisms to provide better protection against viral infection than low-avidity CTLM Derby
Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1578, USA
J Immunol 166:1690-7. 2001....
- Analysis of the copy number profiles of several tumor samples from the same patient reveals the successive steps in tumorigenesisEric Letouze
INSERM, UMR S 973, MTI, Universite Paris Diderot Paris 7, 35 rue Helene Brion, 75205 Paris Cedex 13, France
Genome Biol 11:R76. 2010....
- Population genetics of cancer cell clones: possible implications of cancer stem cellsChristopher T Naugler
Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, C414, Diagnostic and Scientific Centre, 9, 3535 Research Road NW, Calgary AB, T2L 2K8 Canada
Theor Biol Med Model 7:42. 2010..Cancer cell clones can be conceptualized as sympatric asexual species, and as such, the application of theoretical population genetics as it pertains to asexual species may provide additional insights...
- One NY-ESO-1-derived epitope that promiscuously binds to multiple HLA-DR and HLA-DP4 molecules and stimulates autologous CD4+ T cells from patients with NY-ESO-1-expressing melanomaMaja Mandic
Department of Medicine and The Melanoma Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
J Immunol 174:1751-9. 2005..They also support the relevance of cancer vaccine trials with peptides NY-ESO-1 87-111 in the large number of cancer patients with NY-ESO-1-expressing tumors...
- Different NK cell surface phenotypes defined by the DX9 antibody are due to KIR3DL1 gene polymorphismC M Gardiner
Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 166:2992-3001. 2001....
- A rhoptry-protein-associated mechanism of clonal phenotypic variation in rodent malariaP R Preiser
Division of Parasitology, National Institute for Medical Research, London, UK
Nature 398:618-22. 1999..This phenomenon is genetically and functionally distinct from classical antigenic variation, which is mediated by the var multigene family of P. falciparum...
- Prediction of Lupus Outcome by Gene Expression PatternsRobert Winchester; Fiscal Year: 2006..Second, whether CellCept will prove to be efficacious in a different gene expression subset, suggesting it could be used in these cases as a less toxic alternative to Cytoxan. ..
- Immunopathogenic features in calcific aortic stenosisRobert Winchester; Fiscal Year: 2009..abstract_text> ..
- Measurement & modulation of the mutation rate in humansDavid Araten; Fiscal Year: 2007..These studies will begin to elucidate the relationship between f and cancer risk and provide a highly relevant in vitro parameter with which to evaluate chemoprevention. ..
- RHESUS MACAQUE MODEL OF TUBERCULOSISDAVID LEWINSOHN; Fiscal Year: 2001..g., CT scans, quantitative culture of mycobacteria from BAL fluids and liver biopsies) which correlate with survival. ..
- GENERATION OF THOMSEN-FREIDENREICH-SPECIFIC T CELLSAlessandra Franco; Fiscal Year: 2002..Two strategies will be compared: 1) passive immunotherapy by T cell transfer with selected T cell clones; and 2) active vaccination with the glycopeptides and glycolipids to generate a TF-specific T cell response. ..
- HSV-SERONEGATIVE PERSONS WITH AQUIRED IMMUNITY TO HSVChristine Posavad; Fiscal Year: 2002..abstract_text> ..
- Oxygen Guided Hypofractionated Radiotherapy for GliomasNadeem Khan; Fiscal Year: 2010....
- Large-scale chromatin structure and dynamicsAndrew Belmont; Fiscal Year: 2007..Knowledge gained from this research should provide valuable insight into regulation of basic molecular processes and may serve to guide design of future gene therapy vectors and stable transgene expression. ..
- Targeted tumoricidal bacteriaMing Zhao; Fiscal Year: 2007..Future human trials of the tumor-killing bacteria can be held after the Phase I and Phase II grant periods are completed. [unreadable] [unreadable] [unreadable]..
- Dev & Testing of New Medications for Treatment of Emerging Infectious DiseasesMitchell Avery; Fiscal Year: 2006..This allows LADDS infrastructure to inch forward now to the last stages of drug development that are achievable with academic economics. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Becton Dickinson LSR-II Analytical Cytometer (BD-LSR-II)David Serreze; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- GFP-Based Assays to Probe Transcriptional Controls(RMI)Richard Katz; Fiscal Year: 2005..The assays have the potential to reveal new lead compounds, as well as new gene targets for therapeutics. ..
- Autoimmune Oophoritis: Consequences of Gamete VaccinesKenneth Tung; Fiscal Year: 2006..Specifically, we will determine the immunogenetic regulation of the immune response to CP2, and the influence of the B cell epitope specificity of the ZP Ab on the induction of progenic AOD. ..
- Proteomics Analysis of T Cell Autoantigens in TID2Kathryn Haskins; Fiscal Year: 2005..abstract_text> ..
- A novel set of molecular markers to measure metastatic neuroblastomaNai Kong Cheung; Fiscal Year: 2007..Armed with the tools to collect samples expeditiously and to measure MRD accurately, the paradigm of treating subclinical NB can then be tested in multicenter randomized studies. [unreadable] [unreadable]..
- THE MECHANISMS OF AUTOIMMUNE RESPONSE INITIATION IN MULTIPLE SCLEROSISSilva Markovic Plese; Fiscal Year: 2007..unreadable] [unreadable]..
- Role of Redox Dependent Signaling in LeukemiaJoya Chandra; Fiscal Year: 2010..Tactics that quelch ROS production, or block downstream signaling through Fyn in BCR/ABL containing cells may provide promising therapeutic modalities. ..
- Lactate Transport as a Therapeutic Target in GliomaSAROJ PRIYANTHA MATHUPALA; Fiscal Year: 2010..Thus, we need new ways to target this deadly cancer. We plan to test a novel method to "pickle-the-tumor-to-death," while leaving healthy brain cells intact. ..
- LANGERHANS CELLS AND NERVES: BIDIRECTIONAL SIGNALINGRichard Granstein; Fiscal Year: 2009..Immune responses in the skin. ..
- Comparative genetics of Lesch-Nyhan diseaseJames Thomas; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- 2008 Musculoskeletal Biology and Bioengineering Gordon Research ConferenceFarshid Guilak; Fiscal Year: 2008..The meeting will consist of 9 separate sessions, consisting of invited speakers and selected attendees at various levels of career development. [unreadable] [unreadable] [unreadable] [unreadable]..
- Chlamydia-infected Epithelial Cell Secretion of Immunoregulatory CytokinesWILBERT DERBIGNY; Fiscal Year: 2008..unreadable] DESCRIPTION (provided by applicant): NO ABSTRACT WAS PROVIDED BY THE PI. [unreadable] [unreadable] [unreadable] [unreadable]..
- Epigenetic control of hematopoietic stem cellsChrista Muller Sieburg; Fiscal Year: 2007..Relevance: Data from the proposed studies may provide better ways to treat leukopenia and may help in the design of approaches to selectively eradicate leukemic stem cells. ..
- T CELL IMMUNITY TO MHV 68, A MURINE GAMMA HERPESVIRUSMARCIA BLACKMAN; Fiscal Year: 2008..In Aim 3, we will build on this information and use this well-characterized viral model as a "proof of principal" test for epitope-based vaccination strategies for the gamma-herpesviruses. [unreadable] [unreadable] [unreadable]..
- Adenoviral GFP targeting of metastatic human tumors using multiple delivery routeHiroyuki Kishimoto; Fiscal Year: 2008..Having obtained these results, we can move forward in the Phase II grant application with experiments to bring OBP-401 to the clinic for use in cancer surgery in human patients. [unreadable] [unreadable] [unreadable]..
- CD8+ T Cells Control Autoimmunity In EAEHong Jiang; Fiscal Year: 2007..Thus, the studies will provide theoretical basis for clinical application of this regulatory pathway in prevention and treatment of multiple sclerosis in man. [unreadable] [unreadable] [unreadable]..
- B CLL SUBGROUPS--MATURATION STAGE AND GENE EXPRESSIONNicholas Chiorazzi; Fiscal Year: 2004..Hopefully, these differences will provide important basic and clinical insights into this disease and suggest future prognostic and therapeutic approaches to it. ..
- CHROMOSOME ALTERATIONS IN BARRETT'S ESOPHAGUSTHOMAS PAULSON; Fiscal Year: 2005..The results from these analyses will be of interest to both clinical and basic researchers in studying EA and other cancers. ..
- EBV and HPV: Oral Infection, Persistence & PathogenesisDENNIS WALLING; Fiscal Year: 2003..abstract_text> ..
- Discovery of novel fluorescent reporter genesMing Zhao; Fiscal Year: 2004..Reporters with spectral properties that can be used for whole-body imaging of tumors in the lung and their metastases will be candidates for further development for numerous applications of multi-color imaging. ..
- Astrocytes As Multipotent Stem CellsERIC LAYWELL; Fiscal Year: 2003....
- CD8+ T CELL RECOGNITION OF TH1 AND TH2Hong Jiang; Fiscal Year: 2003..We will determine if this difference uniquely applies to the recognition of TCR peptide presented by Qa-1 or if CD8+ T cells specific for other peptides presented by MHC class I molecules also distinguish between TH1 and TH2 targets. ..
- 3D Woven Scaffolds for Tissue EngineeringFarshid Guilak; Fiscal Year: 2003..An improved level of biomechanical function will increase the level of success in the engineered repair of various tissues of the musculoskeletal system as well as other organ systems of the body. ..
- Molecular Mechanisms of Aging: 33rd Ann. Mtg. of AGENorman Wolf; Fiscal Year: 2004..Dr. Bickford has investigated hotel accommodations there and has found that both the Radisson and the Hilton offer excellent accommodations for the meeting. She is negotiating with both. ..
- TARGETED DELIVERY OF GENES TO ANGIOGENIC VASCULATURERenata Pasqualini; Fiscal Year: 2004..Given that our peptides also target angiogenic vasculature in the retina, these advances are also likely to extend the potential for neovasculature-specific gene therapy targeting to other diseases involving angiogenesis. ..
- Ciprofloxacin resistance and compensatory Mutations.Julian Adams; Fiscal Year: 2004..Knowledge of the biochemical and physiological basis of compensatory mutations may allow the design of strategies to reduce or counteract their role in increasing the prevalence of antibiotic resistant mutations. ..
- VASCULAR CELL CATIONIC AMINO ACID TRANSPORT & METABOLISMANDREW SCHAFER; Fiscal Year: 2002..Elucidation of the molecular mechanisms that modulate the response to vascular injury will provide new rational targets for therapeutic intervention. ..
- B220+DN Tcells in Mucosal Tolerance and InflammationABDEL HAMAD; Fiscal Year: 2005..In addition, they lay the groundwork for the analysis of B220+ DN T cell in healthy individuals and IBD patients. ..
- FTI Biology & Treatment of Myeloproliferative DisordersJason Gotlib; Fiscal Year: 2005..If clinically efficacious, further studies of R115777 in MPDs will be warranted...
- DOSAGE COMPENSATION IN MAMMALS: X-INACTIVATIONSTANLEY GARTLER; Fiscal Year: 2004..Such border shifting may have evolutionary implications for genome organization. We propose an extensive test of this model. ..
- Human Resistance to Herpes Simplex Virus InfectionsChristine Posavad; Fiscal Year: 2005..The data generated will be relevant to designing and evaluating strategies for HSV-2 preventative vaccines and immunotherapy. ..
- Enzyme therapy for hyperhomocysteinemiaYuying Tan; Fiscal Year: 2005..Phase II results will lead to an IND for MEGC-PEG-rMETase for end stage renal disease patients and other patients with intractable hyperhomocysteinemia and high cardiovascular disease mortality. ..
- REGULATION OF THE TYPE II TGF -B- RECEPTORARNOLD RIZZINO; Fiscal Year: 2002..Together, Dr. Rizzino feels that these studies will not only help determine how the TbetaR-II gene is regulated normally, but they will also provide the groundwork for understanding why this gene is aberrantly expressed in tumors. ..
- Inhibitors of 5alpha-reductase for acne therapyLingna Li; Fiscal Year: 2002..PROPOSED COMMERCIAL APPLICATIONS: Liposomal 4-MA will be developed as a topical selectively targeted therapeutic for acne for which they should be a very market. ..
- RHOMOCYCSTEINASE FOR HOMOCYSTEINE ASSAYYuying Tan; Fiscal Year: 2002..The tHCY enzymatic kits for these applications will be ready for commercial launch at this point. PROPOSED COMMERCIAL APPLICATION: Not Available ..
- Spindle Formation and Function in Oocytes and Early EmbryosKeith E Latham; Fiscal Year: 2010....
- EFFECT OF CLONING IN EPIGENETIC INHERITANCE IN MICEKeith Latham; Fiscal Year: 2004..These studies are relevant to problems of human infertility and a variety of diseases involving inappropriate epigenetic regulation of gene function. ..
- DEVELOPMENT OF NOVEL ANTIFUNGAL ANTIPC NATURAL PRODUCTSMitchell Avery; Fiscal Year: 2001....
- Ras-PI3K Pathway in Nf1-/-Hematopoiesis and LeukemiaDavid Ingram; Fiscal Year: 2007..abstract_text> ..
- CHRONIC PROSTATITIS COLLABORATIVE CLINICAL STUDIESRichard Alexander; Fiscal Year: 2007..abstract_text> ..
- EIAV Control by High Avidity Rev-Specific CTL ClonesROBERT MEALEY; Fiscal Year: 2005..The information obtained from the proposed studies should have implications for HIV-1 immunotherapy and vaccine design, where experiments of this type may be more difficult. ..
- Mucosal and Peripheral NK-T Cells in HIV InfectionOtto Yang; Fiscal Year: 2007..Exploring NK-T cells in HIV-1 infection could there have a high impact on the development of new strategies in prevention and treatment. [unreadable] [unreadable]..
- Contrasting Properties of Integrin Cytoplasmic DomainsRenata Pasqualini; Fiscal Year: 2004..A better understanding of angiogenesis and new ways of manipulating such process in physiological and pathological situations may result from this work. ..
- Preimplantation Embryo Blastomere FragmentationKeith Latham; Fiscal Year: 2006..Last, because studies such as those proposed cannot be conducted in the human, the proposed studies will provide unprecedented data regarding the relationship between fragmentation and viability. ..
- Training in Biomolecular and Tissue EngineeringFarshid Guilak; Fiscal Year: 2007..We will also take advantage of several long-standing and successful initiatives at Duke University to enhance the recruitment of underrepresented minorities as part of this post-doctoral training program. ..
- ASSESSMENT OF CLINICAL RETINOID ACTIVITY IN LEUKEMIARobert Gallagher; Fiscal Year: 2009..Accomplishment of these aims may define a novel mechanism of gene-targeted drug resistance and provide greater understanding of clonal evolution in a therapeutic setting leading to relapse. ..
- Vaccine Development: Purinergic Agonists as AdjuvantsRichard Granstein; Fiscal Year: 2005..5) This work may provide insights into the physiological processes that modulate the immune response and further our understanding of the mechanisms of established adjuvants. ..
- Insulin Producing Cells from Amniotic Stem Cells for Diabetes TherapyAnthony Atala; Fiscal Year: 2009..Successful development of an abundant source of transplantable insulin producing cells potentially would have a profound impact on the treatment of a major public health problem. ..
- Molecular Mechanisms Regulating Drosophila Ovarian Germline Stem CellsTing Xie; Fiscal Year: 2010..Therefore, this proposed study will surely contribute to a better understanding of stem cell biology, cancer formation and aging as well as to using stem cells in future regenerative medicine. ..
- Mycobacterium tuberculosis-reactive thymocytesMARIELLE GOLD; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- GENE SPECIFIC MUTATIONS IN SKIN INDUCED BY PEROXYNITRITEFredika Robertson; Fiscal Year: 2001..The hypothesis driving this research is that NO and peroxynitrite are mutagenic, and could be important contributors to oxidative DNA damage and mutation in human epidermal keratinocytes at sites of inflammation. ..
- TLS and TLS Fusion Proteins in LeukemiaLiu Yang; Fiscal Year: 2005..It is envisioned that successful completion of this project will unveil potential therapeutic targets in the treatment of human leukemias characterized by the t(16;21) translocation. ..
- Survivin expression and cancer cell drug resistanceFengzhi Li; Fiscal Year: 2008..unreadable] [unreadable]..
- PEM HOMEOBOX GENEMiles Wilkinson; Fiscal Year: 2002..An understanding of the role of Pem in reproductive function may lead to advances in the areas of fertility and birth control. ..
- CHONDROGENESIS AND HISTONE MODIFICATION ENZYMESLiu Yang; Fiscal Year: 2007....
- Eosinophil Granule Proteins and Their FunctionsGerald Gleich; Fiscal Year: 2006..Overall, these studies will expand our knowledge of the molecules composing the eosinophil granule and provide new tools to dissect eosinophil function in disease. ..
- THE HYPEREOSINOPHILIC SYNDROMES AND MEPOLIZUMABGerald Gleich; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- BIOENGINEERING OF BLADDER TISSUESAnthony Atala; Fiscal Year: 2003..In this aim we will attempt to determine the phenotypic and functional characteristics, over time, of the bioengineered bladder tissues, as compared to controls. ..