stromal cells

Summary

Summary: Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.

Top Publications

  1. ncbi Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    Antoine E Karnoub
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 449:557-63. 2007
  2. ncbi Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    M Dominici
    Laboratory of Cell Biology and Advanced Cancer Therapy, Oncology Hematology Department, University of Modena and Reggio Emilia, Modena, Italy
    Cytotherapy 8:315-7. 2006
  3. ncbi Multilineage cells from human adipose tissue: implications for cell-based therapies
    P A Zuk
    Laboratory for Regenerative Bioengineering and Repair, UCLA School of Medicine, Los Angeles, California, USA
    Tissue Eng 7:211-28. 2001
  4. ncbi Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    Massimo Di Nicola
    Cristina Gandini Bone Marrow Transplantation Unit, Istituto Nazionale Tumori, Milano, Italy
    Blood 99:3838-43. 2002
  5. ncbi Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views
    Donald G Phinney
    Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA
    Stem Cells 25:2896-902. 2007
  6. ncbi Osteoblastic cells regulate the haematopoietic stem cell niche
    L M Calvi
    Endocrine Unit, Department of Medicine, Center for Human Genetics and Molecular Pediatric Disease, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Nature 425:841-6. 2003
  7. ncbi Tensional homeostasis and the malignant phenotype
    Matthew J Paszek
    Department of Bioengineering, University of Pennsylvania, Philadelphia, 19104, USA
    Cancer Cell 8:241-54. 2005
  8. ncbi Immunomodulatory properties of mesenchymal stromal cells
    Alma J Nauta
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Blood 110:3499-506. 2007
  9. ncbi Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms
    T Kinnaird
    Cardiovascular Research Institute, Washington, DC 20010, USA
    Circulation 109:1543-9. 2004
  10. ncbi Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells
    Jalees Rehman
    Krannert Institute of Cardiology, Indiana Center for Vascular Biology and Medicine, Indianapolis, Ind 46202, USA
    Circulation 109:1292-8. 2004

Research Grants

  1. Metabolic mechanisms of antiestrogen resistance in breast cancer
    UBALDO EMILIO MARTINEZ OUTSCHOORN; Fiscal Year: 2013
  2. Tumor Microenvironment Interactions in Brain Tumors
    Eric C Holland; Fiscal Year: 2010
  3. EPIMORPHIN DELETION ALTERS STEM CELL NICHE MYOFIBROBLAST SECRETION
    Anisa Shaker; Fiscal Year: 2012
  4. Mechanisms of Stem Cell Self-Renewal and Aging
    PAUL CHRISTIAN SCHILLER; Fiscal Year: 2013
  5. Inhibition of bone formation by Prx1
    Mark S Nanes; Fiscal Year: 2013
  6. Antibody-mediated Gene Therapy for the Treatment of Cancer
    TRACY RUTH DANIELS-WELLS; Fiscal Year: 2013
  7. Pluripotent stem cell-derived HSCs: improvements and molecular mechanisms
    Patrick Cahan; Fiscal Year: 2013
  8. Mechanism of Irradiation Pulmonary Fibrosis
    Joel S Greenberger; Fiscal Year: 2012
  9. Mechanisms of Airway Smooth Muscle Hypertrophy
    Marc B Hershenson; Fiscal Year: 2013
  10. Signal Transduction Mechanism of Osteoclast Differentiation
    Nandini Ghosh-Choudhury; Fiscal Year: 2013

Detail Information

Publications381 found, 100 shown here

  1. ncbi Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    Antoine E Karnoub
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 449:557-63. 2007
    ..Collectively, these data demonstrate that the tumour microenvironment facilitates metastatic spread by eliciting reversible changes in the phenotype of cancer cells...
  2. ncbi Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    M Dominici
    Laboratory of Cell Biology and Advanced Cancer Therapy, Oncology Hematology Department, University of Modena and Reggio Emilia, Modena, Italy
    Cytotherapy 8:315-7. 2006
    The considerable therapeutic potential of human multipotent mesenchymal stromal cells (MSC) has generated markedly increasing interest in a wide variety of biomedical disciplines...
  3. ncbi Multilineage cells from human adipose tissue: implications for cell-based therapies
    P A Zuk
    Laboratory for Regenerative Bioengineering and Repair, UCLA School of Medicine, Los Angeles, California, USA
    Tissue Eng 7:211-28. 2001
    ..In conclusion, the data support the hypothesis that a human lipoaspirate contains multipotent cells and may represent an alternative stem cell source to bone marrow-derived MSCs...
  4. ncbi Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    Massimo Di Nicola
    Cristina Gandini Bone Marrow Transplantation Unit, Istituto Nazionale Tumori, Milano, Italy
    Blood 99:3838-43. 2002
    CD2(+) T lymphocytes obtained from either the donor of bone marrow stromal cells (BMSCs) or a third party were cultured in mixed lymphocyte reactions (MLRs) with either allogeneic dendritic cells (DCs) or peripheral blood lymphocytes (..
  5. ncbi Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views
    Donald G Phinney
    Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA
    Stem Cells 25:2896-902. 2007
    Mesenchymal stem cells or multipotent stromal cells (MSCs) isolated from the bone marrow of adult organisms were initially characterized as plastic adherent, fibroblastoid cells with the capacity to generate heterotopic osseous tissue ..
  6. ncbi Osteoblastic cells regulate the haematopoietic stem cell niche
    L M Calvi
    Endocrine Unit, Department of Medicine, Center for Human Genetics and Molecular Pediatric Disease, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Nature 425:841-6. 2003
    ..Niche constituent cells or signalling pathways provide pharmacological targets with therapeutic potential for stem-cell-based therapies...
  7. ncbi Tensional homeostasis and the malignant phenotype
    Matthew J Paszek
    Department of Bioengineering, University of Pennsylvania, Philadelphia, 19104, USA
    Cancer Cell 8:241-54. 2005
    ..Thus, ERK and Rho constitute part of an integrated mechanoregulatory circuit linking matrix stiffness to cytoskeletal tension through integrins to regulate tissue phenotype...
  8. ncbi Immunomodulatory properties of mesenchymal stromal cells
    Alma J Nauta
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Blood 110:3499-506. 2007
    ....
  9. ncbi Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms
    T Kinnaird
    Cardiovascular Research Institute, Washington, DC 20010, USA
    Circulation 109:1543-9. 2004
    ..Bone marrow cell therapy is reported to contribute to collateral formation through cell incorporation into new or remodeling vessels. However, the possible role of a paracrine contribution to this effect is less well characterized...
  10. ncbi Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells
    Jalees Rehman
    Krannert Institute of Cardiology, Indiana Center for Vascular Biology and Medicine, Indianapolis, Ind 46202, USA
    Circulation 109:1292-8. 2004
    ..The beneficial effects of delivered cells appear to be related to their pluripotency and ability to secrete growth factors. We examined nonadipocyte stromal cells from human subcutaneous fat as a novel source of therapeutic cells.
  11. pmc Stromal fibroblasts in cancer initiation and progression
    Neil A Bhowmick
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Nature 432:332-7. 2004
    ..Recent studies reveal that fibroblasts have a more profound influence on the development and progression of carcinomas than was previously appreciated. These new findings have important therapeutic implications...
  12. ncbi Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation
    William T Tse
    Division of Hematology Oncology, Children s Hospital, Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    Transplantation 75:389-97. 2003
    Marrow stromal cells (MSC) can differentiate into multiple mesenchymal tissues...
  13. pmc Pten in stromal fibroblasts suppresses mammary epithelial tumours
    ANTHONY J TRIMBOLI
    Department of Molecular Genetics, College of Biological Sciences, The Ohio State University, Columbus, Ohio 43210, USA
    Nature 461:1084-91. 2009
    ..Global gene expression profiling of mammary stromal cells identified a Pten-specific signature that was highly represented in the tumour stroma of patients with breast ..
  14. ncbi Surface protein characterization of human adipose tissue-derived stromal cells
    S Gronthos
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, Bethesda, Maryland, USA
    J Cell Physiol 189:54-63. 2001
    Human bone marrow stromal cells are a multipotent population of cells capable of differentiating into a number of mesodermal lineages as well as supporting hematopoeisis...
  15. pmc Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
    Aarif Y Khakoo
    Laboratory of Molecular Biology, Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:1235-47. 2006
    Emerging evidence suggests that both human stem cells and mature stromal cells can play an important role in the development and growth of human malignancies...
  16. ncbi A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks
    Dmitry O Traktuev
    Indiana Center for Vascular Biology and Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Circ Res 102:77-85. 2008
    ..Analysis of surface and intracellular markers of the freshly isolated CD34+/CD31-/CD144- adipose-derived stromal cells (ASCs) showed that >90% coexpress mesenchymal (CD10, CD13, and CD90), pericytic (chondroitin sulfate ..
  17. ncbi Projection of an immunological self shadow within the thymus by the aire protein
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Science 298:1395-401. 2002
    ..The mutant animals exhibited a defined profile of autoimmune diseases that depended on the absence of aire in stromal cells of the thymus...
  18. pmc Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6
    Ryang Hwa Lee
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Cell Stem Cell 5:54-63. 2009
    ..v.) infused human multipotent stromal cells (hMSCs) can enhance tissue repair without significant engraftment. After 2 x 10(6) hMSCs were i.v...
  19. ncbi Tumor stroma and regulation of cancer development
    Thea D Tlsty
    Department of Pathology and Comprehensive Cancer Center, University of California, San Francisco, California 94115, USA
    Annu Rev Pathol 1:119-50. 2006
    ..that, like organogenesis during embryonic development and tissue repair in adult mammals, are regulated by interactions between epithelial cells, activated stromal cells, and soluble and insoluble components of the extracellular matrix.
  20. ncbi Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches
    Tatsuki Sugiyama
    Department of Medical Systems Control, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Immunity 25:977-88. 2006
    ..CXCL12-CXCR4 signaling plays an essential role in maintaining the quiescent HSC pool, and CAR cells appear to be a key component of HSC niches, including both vascular and endosteal niches in adult bone marrow...
  21. pmc Microenvironmental regulation of metastasis
    Johanna A Joyce
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, USA
    Nat Rev Cancer 9:239-52. 2009
    ..This Review describes experimental data demonstrating the role of the microenvironment in metastasis, identifies areas for future research and suggests possible new therapeutic avenues...
  22. pmc Stromal cells in tumor microenvironment and breast cancer
    Yan Mao
    Shanghai Ruijin Hospital, Comprehensive Breast Health Center, Shanghai, China
    Cancer Metastasis Rev 32:303-15. 2013
    Cancer is a systemic disease encompassing multiple components of both tumor cells themselves and host stromal cells. It is now clear that stromal cells in the tumor microenvironment play an important role in cancer development...
  23. doi Stromal gene expression predicts clinical outcome in breast cancer
    Greg Finak
    McGill Centre for Bioinformatics, 3775 University Street, McGill University, Quebec H3A 2B4, Canada
    Nat Med 14:518-27. 2008
    ..Genes represented in the SDPP reveal the strong prognostic capacity of differential immune responses as well as angiogenic and hypoxic responses, highlighting the importance of stromal biology in tumor progression...
  24. ncbi Marrow stromal cells as stem cells for nonhematopoietic tissues
    D J Prockop
    Center for Gene Therapy, Allegheny University of the Health Sciences, MCP Hahnemann School of Medicine, 245 North 15 Street, Mail Stop 421, Philadelphia, PA 19102, USA
    Science 276:71-4. 1997
    Marrow stromal cells can be isolated from other cells in marrow by their tendency to adhere to tissue culture plastic...
  25. ncbi Friends or foes - bipolar effects of the tumour stroma in cancer
    Margareta M Mueller
    Group Tumor and Microenvironment, German Cancer Research Centre, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nat Rev Cancer 4:839-49. 2004
    ..What have we recently learned from studying tumour-stroma interactions, and will this help to define new targets for therapy?..
  26. pmc Cardiac telocytes were decreased during myocardial infarction and their therapeutic effects for ischaemic heart in rat
    Baoyin Zhao
    Key Laboratory for Regenerative Medicine, Ministry of Education, Ji Nan University, Guangzhou, China
    J Cell Mol Med 17:123-33. 2013
    ..Rebuilding the cardiac telocyte network in the infarcted zone following MI may be beneficial for functional regeneration of the infarcted myocardium...
  27. ncbi Immunophenotype of human adipose-derived cells: temporal changes in stromal-associated and stem cell-associated markers
    James B Mitchell
    Cognate Therapeutics, Inc, Baltimore, MD, USA
    Stem Cells 24:376-85. 2006
    ....
  28. pmc Cancer-associated stromal fibroblasts promote pancreatic tumor progression
    Rosa F Hwang
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1402, USA
    Cancer Res 68:918-26. 2008
    ..These data indicate that stellate cells have an important role in supporting and promoting pancreatic cancer. Identification of HPSC-derived factors may lead to novel stroma-targeted therapies for pancreatic cancer...
  29. pmc Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses
    Tangsheng Yi
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Immunity 37:535-48. 2012
    ..We showed that all three enzymes control EBI2 ligand concentration in lymphoid tissues. Lymphoid stromal cells were the main CH25H- and CYP7B1-expressing cells required for positioning of B cells, and they also mediated 7╬..
  30. pmc Cardiomyocytes can be generated from marrow stromal cells in vitro
    S Makino
    Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Invest 103:697-705. 1999
    We have isolated a cardiomyogenic cell line (CMG) from murine bone marrow stromal cells. Stromal cells were immortalized, treated with 5-azacytidine, and spontaneously beating cells were repeatedly screened...
  31. pmc How to track cellular aging of mesenchymal stromal cells?
    Wolfgang Wagner
    Helmholtz Institute for Biomedical Engineering, Department of Cell Biology, RWTH Aachen University Medical School, 52074 Aachen, Germany
    Aging (Albany NY) 2:224-30. 2010
    Mesenchymal stromal cells (MSC) are currently tested in a large number of clinical trials and raise high hope in regenerative medicine...
  32. ncbi Telocytes, a distinct type of cell among the stromal cells present in the lamina propria of jejunum
    D Cretoiu
    Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    Histol Histopathol 27:1067-78. 2012
    ..Tps present dichotomous branching and form a three dimensional network close to immune cells, SMCs or nerve bundles. TCs could play a role in intercellular signaling and control of local tissue homeostasis...
  33. ncbi Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    Akira Orimo
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 121:335-48. 2005
    Fibroblasts often constitute the majority of the stromal cells within a breast carcinoma, yet the functional contributions of these cells to tumorigenesis are poorly understood...
  34. pmc Telocytes and putative stem cells in the lungs: electron microscopy, electron tomography and laser scanning microscopy
    Laurentiu M Popescu
    Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    Cell Tissue Res 345:391-403. 2011
    ..In conclusion, this study shows the presence of TCs in lungs and identifies a TC-SC tandem in subepithelial niches of the bronchiolar tree. In TC-SCNs, the synergy of TCs and SCs may be based on nanocontacts and shed vesicles...
  35. ncbi Bone marrow stromal cells generate muscle cells and repair muscle degeneration
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoecho, Sakyo ku, Kyoto, 606 8501 Japan
    Science 309:314-7. 2005
    Bone marrow stromal cells (MSCs) have great potential as therapeutic agents. We report a method for inducing skeletal muscle lineage cells from human and rat general adherent MSCs with an efficiency of 89%...
  36. ncbi Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement
    E M Horwitz
    Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cytotherapy 7:393-5. 2005
    ..cells, regardless of the tissue from which they are isolated, be termed multipotent mesenchymal stromal cells, while the term mesenchymal stem cells is used only for cells that meet specified stem cell criteria...
  37. doi A paracrine requirement for hedgehog signalling in cancer
    Robert L Yauch
    Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 455:406-10. 2008
    ..Taken together, these studies demonstrate a paracrine requirement for Hh ligand signalling in the tumorigenesis of Hh-expressing cancers and have important implications for the development of Hh pathway antagonists in cancer...
  38. ncbi Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells
    Karin Stenderup
    University Department of Endocrinology and Metabolism, University Hospital of Aarhus, DK 8000 Aarhus C, Denmark
    Bone 33:919-26. 2003
    ..However, the cellular causes are not known. Thus, we have established cultures of bone marrow stromal cells (MSC) from young (aged 18-29 years, n = 6) and old (aged 68-81 years, n = 5) donors...
  39. pmc Dependency of colorectal cancer on a TGF-╬▓-driven program in stromal cells for metastasis initiation
    Alexandre Calon
    Oncology Programme, Institute for Research in Biomedicine, 08028 Barcelona, Spain
    Cancer Cell 22:571-84. 2012
    ..The activity of TGF-╬▓ on stromal cells increases the efficiency of organ colonization by CRC cells, whereas mice treated with a pharmacological ..
  40. pmc miR-193 expression differentiates telocytes from other stromal cells
    V B Cismasiu
    Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    J Cell Mol Med 15:1071-4. 2011
    ..In addition, the miRs which are specific to CMC and other muscle cells (e.g. miR-133a, miR-208a) are absent in TCs. Overall the data reinforce the view that TCs are a particular type of interstitial (mesenchymal) cells...
  41. pmc Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
    Simon Mendez-Ferrer
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 466:829-34. 2010
    ..These results uncover an unprecedented partnership between two distinct somatic stem-cell types and are indicative of a unique niche in the bone marrow made of heterotypic stem-cell pairs...
  42. doi Adipocyte differentiation of human bone marrow-derived stromal cells is modulated by microRNA-155, microRNA-221, and microRNA-222
    Magne Sk├ąrn
    Department of Tumor Biology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway
    Stem Cells Dev 21:873-83. 2012
    Human mesenchymal stromal cells (hMSCs) are capable of limited self-renewal and multilineage differentiation in vitro...
  43. ncbi Role of tissue stroma in cancer cell invasion
    Olivier De Wever
    Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    J Pathol 200:429-47. 2003
    ....
  44. pmc Gene expression profiling of the tumor microenvironment during breast cancer progression
    Xiao Jun Ma
    bioTheranostics, Inc, 11025 Roselle Street, San Diego, CA 92121, USA
    Breast Cancer Res 11:R7. 2009
    ..We conducted a comparative analysis of global gene expression changes in the stromal and epithelial compartments during breast cancer progression from normal to preinvasive to invasive ductal carcinoma...
  45. pmc Altered TGF-╬▓ signaling in a subpopulation of human stromal cells promotes prostatic carcinogenesis
    Omar E Franco
    Departments of Urologic Surgery and Cancer Biology, Vanderbilt University Medical Center, Vanderbilt Ingram Cancer Center, Nashville, Tennessee, USA
    Cancer Res 71:1272-81. 2011
    ..In combination, these two populations of stromal cells recapitulated the tumor inductive activity of CAFs...
  46. ncbi G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
    Isabelle Petit
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Nat Immunol 3:687-94. 2002
    ..We suggest that manipulation of SDF-1 CXCR4 interactions may be a means with which to control the navigation of progenitors between the BM and blood to improve the outcome of clinical stem cell transplantation...
  47. ncbi Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms
    T Kinnaird
    Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA
    Circ Res 94:678-85. 2004
    We recently demonstrated that marrow stromal cells (MSCs) augment collateral remodeling through release of several cytokines such as VEGF and bFGF rather than via cell incorporation into new or remodeling vessels...
  48. pmc T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
    F Fossiez
    Schering Plough, Laboratory for Immunological Research, Dardilly, France
    J Exp Med 183:2593-603. 1996
    ..These observations suggest that hIL-17 may constitute (a) an early initiator of the T cell-dependent inflammmatory reaction; and (b) an element of the cytokine network that bridges the immune system to hematopoiesis...
  49. ncbi Stromal biology of pancreatic cancer
    Gerald C Chu
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    J Cell Biochem 101:887-907. 2007
    ..Such knowledge may be used to understand the evolution and biology of this lethal cancer and may convert these insights into new points of therapeutic intervention...
  50. pmc Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury
    Mohammad Naimul Islam
    Lung Biology Laboratory, Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Nat Med 18:759-65. 2012
    Bone marrow-derived stromal cells (BMSCs) protect against acute lung injury (ALI)...
  51. doi Gap junction-mediated import of microRNA from bone marrow stromal cells can elicit cell cycle quiescence in breast cancer cells
    Philip K Lim
    New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    Cancer Res 71:1550-60. 2011
    ..This study shows that the transfer of miRNAs from BM stroma to BC cells might play a role in the dormancy of BM metastases...
  52. pmc Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice
    Ryang Hwa Lee
    Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 103:17438-43. 2006
    We tested the hypothesis that multipotent stromal cells from human bone marrow (hMSCs) can provide a potential therapy for human diabetes mellitus...
  53. pmc DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells
    Simone Bork
    Department of Medicine V, University of Heidelberg, 69120 Heidelberg, Germany
    Aging Cell 9:54-63. 2010
    Within 2-3 months of in vitro culture-expansion, mesenchymal stromal cells (MSC) undergo replicative senescence characterized by cell enlargement, loss of differentiation potential and ultimate growth arrest...
  54. doi Transcriptional profile of native CD271+ multipotential stromal cells: evidence for multiple fates, with prominent osteogenic and Wnt pathway signaling activity
    Sarah M Churchman
    NIHR Leeds Musculoskeletal Biomedical Research Unit and University of Leeds, Leeds, UK
    Arthritis Rheum 64:2632-43. 2012
    Controversy surrounds the identity and functionality of rare bone marrow-derived multipotential stromal cells (BM-MSCs), including their differentiation capabilities, their relationship to pericytes and hematopoiesis-supporting stromal ..
  55. doi Telocytes in the interstitium of human exocrine pancreas: ultrastructural evidence
    Mihnea I Nicolescu
    Department of Molecular Medicine, Victor Babes National Institute of Pathology, Bucharest, Romania
    Pancreas 41:949-56. 2012
    ..Telocytes were initially described as interstitial Cajal-like cells, but it gradually became clear that they were a distinct novel cell type not directly related to canonical interstitial Cajal cells...
  56. ncbi Multipotential human adipose-derived stromal stem cells exhibit a perivascular phenotype in vitro and in vivo
    A C W Zannettino
    Myeloma Research Program, Bone and Cancer Laboratories, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute and University of Adelaide, Adelaide, Australia
    J Cell Physiol 214:413-21. 2008
    ..exhibited similar phenotypic profiles in relation to their expression of cell surface markers associated with stromal cells (CD44, CD90, CD105, CD106, CD146, CD166, STRO-1, alkaline phosphatase), endothelial cells (CD31, CD105, CD106, ..
  57. pmc MiR-886-3p down regulates CXCL12 (SDF1) expression in human marrow stromal cells
    Manoj M Pillai
    Division of Medical Oncology, Department of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America
    PLoS ONE 5:e14304. 2010
    ..Screening studies showed that when miR-886-3p was transfected into the CXCL12+ stromal cells, the expression of CXCL12 was down-regulated by as much as 85% when compared to appropriate controls, and ..
  58. doi Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation
    Karin Tarte
    INSERM U917, Universite Rennes 1, Rennes, France
    Blood 115:1549-53. 2010
    Clinical-grade human mesenchymal stromal cells (MSCs) have been expanded in vitro for tissue engineering or immunoregulatory purposes without standardized culture conditions or release criteria...
  59. doi Hospicells (ascites-derived stromal cells) promote tumorigenicity and angiogenesis
    Marlene Pasquet
    EA3035, Institut Claudius Regaud, University Toulouse III, Faculte des sciences pharmaceutiques, Toulouse, F 31062, France
    Int J Cancer 126:2090-101. 2010
    ..Collectively, these data indicate a role for these ascite-derived stromal cells in promoting tumor growth by increasing angiogenesis.
  60. pmc VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization
    Joyce T O'Connell
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:16002-7. 2011
    ..the metastatic capabilities of S100A4(+) cancer cells have been examined, the functional role of S100A4(+) stromal cells in metastasis is largely unknown...
  61. pmc BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b
    Shoichiro Kokabu
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Mol Endocrinol 26:87-94. 2012
    ..Using in vitro cultures of primary bone marrow stromal cells, we show that overexpression of BMP3 suppresses OBL differentiation, whereas loss of BMP3 increases colony-..
  62. doi Immunomodulatory properties of mesenchymal stromal cells and their therapeutic consequences for immune-mediated disorders
    Senming Zhao
    Institute of Immunology, Technical University of Dresden, Fetscherstr 74, Dresden 01307, Germany
    Stem Cells Dev 19:607-14. 2010
    Bone marrow-derived mesenchymal stromal cells (MSCs) represent a population of nonhematopoietic cells, which play a crucial role in supporting hematopoiesis and can differentiate into various cell types such as osteocytes, chondrocytes, ..
  63. ncbi Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential
    Maxim A Vodyanik
    Department of Pathology and Laboratory Medicine, Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53792 8550, USA
    Blood 105:617-26. 2005
    ..Using coculture of human ES (hES) cells with OP9 bone marrow stromal cells, we were able to obtain up to 20% of CD34+ cells and isolate up to 10(7) CD34+ cells with more than 95% purity ..
  64. pmc Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Clin Invest 113:1701-10. 2004
    Bone marrow stromal cells (MSCs) have the capability under specific conditions of differentiating into various cell types such as osteocytes, chondrocytes, and adipocytes...
  65. pmc The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells
    Seth B Coffelt
    Tumor Targeting Group, University of Sheffield School of Medicine, Sheffield, United Kingdom
    Proc Natl Acad Sci U S A 106:3806-11. 2009
    Bone marrow-derived mesenchymal stem cells or multipotent mesenchymal stromal cells (MSCs) have been shown to engraft into the stroma of several tumor types, where they contribute to tumor progression and metastasis...
  66. pmc Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts
    Diana Whitaker-Menezes
    Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:1772-83. 2011
    ..Most importantly, our current findings provide a new rationale and novel strategy for anti-cancer therapies, by employing MCT inhibitors...
  67. doi Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha
    Matthew Kraman
    Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, UK
    Science 330:827-30. 2010
    ..2% of all tumor cells in established Lewis lung carcinomas, caused rapid hypoxic necrosis of both cancer and stromal cells in immunogenic tumors by a process involving interferon-╬│ and tumor necrosis factor-╬▒...
  68. pmc Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer
    Shibani Mukherjee
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Cancer Biol Ther 5:674-83. 2006
    ..Determination as to whether the increase in GLI1 and SHH expression in breast cancer indicates a significant increase in hedgehog signaling will require further evaluation...
  69. doi A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer
    Pierre Farmer
    Swiss National Centre of Competence in Research Molecular Oncology, Swiss Institute for Experimental Cancer Research, Ecole Polytechnique Federale de Lausanne, School of Life Sciences, Epalinges s Lausanne, Switzerland
    Nat Med 15:68-74. 2009
    ..These findings identify a previously undescribed resistance mechanism to FEC treatment and suggest that antistromal agents may offer new ways to overcome resistance to chemotherapy...
  70. ncbi LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    Y Gong
    Cell 107:513-23. 2001
    ..These data indicate that Wnt-mediated signaling via LRP5 affects bone accrual during growth and is important for the establishment of peak bone mass...
  71. pmc Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    Kenneth P Olive
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 ORE, UK
    Science 324:1457-61. 2009
    ..Thus, inefficient drug delivery may be an important contributor to chemoresistance in pancreatic cancer...
  72. ncbi Clonogenicity of human endometrial epithelial and stromal cells
    Rachel W S Chan
    Centre for Women s Health Research, Monash University Department of Obstetrics and Gynaecology, Monash Medical Centre, Clayton, Victoria 3168, Australia
    Biol Reprod 70:1738-50. 2004
    ..The aims of this study were to determine 1) the clonogenic activity of human endometrial epithelial and stromal cells, 2) which growth factors support this clonogenic activity, and 3) determine the cellular phenotypes of the ..
  73. pmc Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials
    Manoj M Lalu
    Department of Anesthesiology, University of Ottawa, Ottawa, Canada
    PLoS ONE 7:e47559. 2012
    Mesenchymal stromal cells (MSCs, "adult stem cells") have been widely used experimentally in a variety of clinical contexts...
  74. pmc Collagen reorganization at the tumor-stromal interface facilitates local invasion
    Paolo P Provenzano
    Department of Pharmacology, University of Wisconsin, Madison, WI, USA
    BMC Med 4:38. 2006
    ....
  75. ncbi Diagnosis of gastrointestinal stromal tumors: A consensus approach
    Christopher D M Fletcher
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston MA 02115, USA
    Hum Pathol 33:459-65. 2002
    ....
  76. pmc Identification of telocytes in skeletal muscle interstitium: implication for muscle regeneration
    L M Popescu
    Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    J Cell Mol Med 15:1379-92. 2011
    ..We also described non-satellite (resident) progenitor cell niche. In culture, TCs (but not satellite cells) emerge from muscle explants and form networks suggesting a key role in muscle regeneration and repair, at least after trauma...
  77. ncbi Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats
    J Chen
    Henry Ford Health Sciences Center, Department of Neurology, Detroit, Michigan, USA
    Stroke 32:1005-11. 2001
    BACKGROUND AND PURPOSE: We tested the hypothesis that intravenous infusion of bone marrow derived-marrow stromal cells (MSCs) enter the brain and reduce neurological functional deficits after stroke in rats...
  78. pmc Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International So
    Philippe Bourin
    CSA21, Toulouse, France
    Cytotherapy 15:641-8. 2013
    ..Therapeutics and International Society for Cellular Therapy, this paper sets out to establish minimal definitions of stromal cells both as uncultured stromal vascular fraction (SVF) and as an adherent stromal/stem cells population.
  79. doi Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow
    Karen Bieback
    Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden W├╝rttemberg Hessen, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Stem Cells 27:2331-41. 2009
    Mesenchymal stromal cells (MSCs) are promising candidates for novel cell therapeutic applications. For clinical scale manufacturing, human factors from serum or platelets have been suggested as alternatives to fetal bovine serum (FBS)...
  80. pmc Mouse bone marrow-derived mesenchymal stromal cells turn activated macrophages into a regulatory-like profile
    Julian Maggini
    Instituto de Investigaciones Hematologicas, Academia Nacional de Medicina, Buenos Aires, Argentina
    PLoS ONE 5:e9252. 2010
    In recent years it has become clear that the therapeutic properties of bone marrow-derived mesenchymal stromal cells (MSC) are related not only to their ability to differentiate into different lineages but also to their capacity to ..
  81. ncbi Zoned out: functional mapping of stromal signaling microenvironments in the thymus
    Howard T Petrie
    Scripps Florida Research Institute, Jupiter, Florida 33458, USA
    Annu Rev Immunol 25:649-79. 2007
    ..Summarizing what is known about the signals the thymus delivers to uncommitted progenitors, or to immature T-committed progenitors, to produce functional T cells is the focus of this review...
  82. doi Mesenchymal stem cells: flip side of the coin
    Pravin J Mishra
    Department of Medicine, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 8903, USA
    Cancer Res 69:1255-8. 2009
    ..In this review, we discuss the role of stromal cells in the tumor microenvironment and suggest that by exploring the in vitro/in vivo interplay between different ..
  83. doi Human but not murine multipotent mesenchymal stromal cells exhibit broad-spectrum antimicrobial effector function mediated by indoleamine 2,3-dioxygenase
    R Meisel
    Clinic of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Heinrich Heine University, Medical Faculty, Dusseldorf, Germany
    Leukemia 25:648-54. 2011
    Human multipotent mesenchymal stromal cells (MSCs) exhibit multilineage differentiation potential, support hematopoiesis, and inhibit proliferation and effector function of various immune cells...
  84. pmc TNF-alpha promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells
    Graeme E Glass
    The Kennedy Institute of Rheumatology, Imperial College, Hammersmith, London W6 8LH, United Kingdom
    Proc Natl Acad Sci U S A 108:1585-90. 2011
    ..The osteogenic potential of these cells exceeds that of adipose and skin-derived stromal cells and is equivalent to bone marrow stromal cells...
  85. doi The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts
    Hector Peinado
    Department of Pediatrics, Weill Cornell Medical College, New York, NY 10021, USA
    Semin Cancer Biol 21:139-46. 2011
    ..This review describes old ideas and presents new insights into the role of tumor and bone marrow-derived microvesicles and exosomes in pre-metastatic niche formation and metastasis...
  86. doi Mesenchymal stromal cells: facilitators of successful transplantation?
    Karen English
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, OX3 9DU Oxford, UK
    Cell Stem Cell 7:431-42. 2010
    ..This review examines the in vitro and in vivo evidence for the clinical use of bone marrow derived MSCs...
  87. pmc Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
    Yasushi Kojima
    Cancer Research UK Stromal Tumor Interaction Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester M20 4BX, United Kingdom
    Proc Natl Acad Sci U S A 107:20009-14. 2010
    ..This autocrine-signaling mechanism may prove to be an attractive therapeutic target to block the evolution of tumor-promoting CAFs...
  88. pmc Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML
    Zhihong Zeng
    Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 113:6215-24. 2009
    ..We previously reported that bone marrow-derived stromal cells inhibit chemotherapy-induced apoptosis in acute myeloid leukemia (AML)...
  89. ncbi Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion
    Melissa A Baxter
    Stem Cell Research Group, Giving for Living Postgraduate Centre, Royal Manchester Children s Hospital, M27 4HA, UK
    Stem Cells 22:675-82. 2004
    Human marrow stromal cells (MSCs) can be isolated from bone marrow and differentiate into multiple tissues in vitro and in vivo. These properties make them promising tools in cell and gene therapy...
  90. pmc Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression
    Adam Z Oskowitz
    Center for Gene Therapy and Department of Pharmacology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 105:18372-7. 2008
    ..regulate differentiation in a variety of simpler systems also regulate differentiation of human multipotent stromal cells (hMSCs) from bone marrow...
  91. doi Marrow stromal cells for cell-based therapy: the role of antiinflammatory cytokines in cellular cardiomyoplasty
    Guangyong Chen
    Divisions of Cardiac Surgery and Surgical Research, McGill University Health Center, Montreal, Quebec, Canada
    Ann Thorac Surg 90:190-7. 2010
    The mechanism by which marrow stromal cells (MSCs) improve cardiac function after myocardial infarction (MI) is still unclear...
  92. pmc Concise review: hitting the right spot with mesenchymal stromal cells
    Jakub Tolar
    Division of Hematology, Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Stem Cells 28:1446-55. 2010
    Mesenchymal stromal cells or mesenchymal stem cells (MSCs) have captured considerable scientific and public interest because of their potential to limit physical and immune injury, to produce bioactive molecules and to regenerate tissues...
  93. doi The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation
    Andreas J M├╝ller
    Institute of Microbiology, D BIOL, ETH Zurich, Zurich CH 8093, Switzerland
    Cell Host Microbe 6:125-36. 2009
    ..Bone marrow chimeras indicated that caspase-1 was more important in stromal cells, most likely enterocytes, than in bone marrow-derived cells...
  94. ncbi Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality
    Ichiro Sekiya
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    Stem Cells 20:530-41. 2002
    ..of adult stem cells from bone marrow stroma, variously referred to as mesenchymal stem cells or marrow stromal cells (MSCs)...
  95. doi Lymph node stromal cells support dendritic cell-induced gut-homing of T cells
    Rosalie Molenaar
    Department of Molecular Cell Biology and Immunology, VU Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    J Immunol 183:6395-402. 2009
    ..metabolite produced by retinal dehydrogenases, which are specifically expressed in dendritic cells as well as stromal cells in mucosa-draining lymph nodes...
  96. ncbi Stromal cells protect against acute tubular injury via an endocrine effect
    Baoyuan Bi
    Section of Nephrology, Department of Medicine, Yale University, New Haven, Connecticut 06510, USA
    J Am Soc Nephrol 18:2486-96. 2007
    Emerging evidence suggests that the intravenous injection of bone marrow-derived stromal cells (BMSC) improves renal function after acute tubular injury, but the mechanism of this effect is controversial...
  97. ncbi Stromal cells direct local differentiation of regulatory dendritic cells
    Mattias Svensson
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Immunity 21:805-16. 2004
    ..However, the origins of regulatory DC are poorly understood. Here, we show that spleen-derived stromal cells promote selective development of CD11c(lo)CD45RB(+) IL-10-producing regulatory DC from lineage-negative c-kit(+..
  98. ncbi Adult bone marrow stromal cells differentiate into neural cells in vitro
    J Sanchez-Ramos
    Department of Neurology, University of South Florida, Tampa, USA
    Exp Neurol 164:247-56. 2000
    Bone marrow stromal cells (BMSC) normally give rise to bone, cartilage, and mesenchymal cells. Recently, bone marrow cells have been shown to have the capacity to differentiate into myocytes, hepatocytes, and glial cells...
  99. ncbi The stroma reaction myofibroblast: a key player in the control of tumor cell behavior
    Alexis Desmouliere
    Groupe de Recherches pour l Etude du Foie, INSERM E0362, Institut Federatif de Recherche 66, Pathologies Infectieuses et Cancers, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux Cedex, France
    Int J Dev Biol 48:509-17. 2004
    ..On this basis we suggest that the myofibroblast may represent a new important target of antitumor therapy...
  100. doi The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair
    Agnieszka Arthur
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute University of Adelaide, Adelaide, South Australia, Australia
    J Cell Physiol 218:237-45. 2009
    Four decades after the first isolation and characterization of clonogenic bone marrow stromal cells or mesenchymal stem cells (MSC) in the laboratory of Dr...
  101. ncbi Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity
    Sun Ying
    Department of Asthma, Allergy and Respiratory Science, Guy s, King s and St Thomas GKT School of Medicine, London, United Kingdom
    J Immunol 174:8183-90. 2005
    ..Our data implicate TSLP, TARC/CCL17, MDC/CCL22, and IP-10/CXCL10 in asthma pathogenesis. These may act partly through selective development and retention, or recruitment of Th2 cells bearing their receptors...

Research Grants71

  1. Metabolic mechanisms of antiestrogen resistance in breast cancer
    UBALDO EMILIO MARTINEZ OUTSCHOORN; Fiscal Year: 2013
    ..via upregulation of monocarboxylate transporter 1 (MCT1), nuclear respiration factor 1 (NRF1) and mitoNEET and stromal cells with low OXPHOS metabolism and high catabolism via upregulation of monocarboxylate transporter 4 (MCT4) and ..
  2. Tumor Microenvironment Interactions in Brain Tumors
    Eric C Holland; Fiscal Year: 2010
    ..The central hypothesis is that stromal cells, particularly macrophages and endothelial cells, provide key factors, such as matrix-degrading enzymes, which ..
  3. EPIMORPHIN DELETION ALTERS STEM CELL NICHE MYOFIBROBLAST SECRETION
    Anisa Shaker; Fiscal Year: 2012
    ..Hypothesis 2: Epimorphin deletion alters the secretory function of bone marrow derived myofibroblasts and stromal cells which play a significant role in conferring protection from colitis and CAC...
  4. Mechanisms of Stem Cell Self-Renewal and Aging
    PAUL CHRISTIAN SCHILLER; Fiscal Year: 2013
    ..Bone-forming osteoblasts originate from mesenchymal stromal cells (MSCs) in the bone marrow (BM)...
  5. Inhibition of bone formation by Prx1
    Mark S Nanes; Fiscal Year: 2013
    ..Primary cell culture from marrow stromal cells will be used to test TNF responsiveness...
  6. Antibody-mediated Gene Therapy for the Treatment of Cancer
    TRACY RUTH DANIELS-WELLS; Fiscal Year: 2013
    ..released from targeted cells and taken up by non-targeted malignant cells in the tumor environment as well as stromal cells that support the growth of the malignant cells...
  7. Pluripotent stem cell-derived HSCs: improvements and molecular mechanisms
    Patrick Cahan; Fiscal Year: 2013
    ..of ESCs, ectopic expression of the homeobox transcription factor HoxB4, and co-culture with OP9 stromal cells (Kyba et al 2002)...
  8. Mechanism of Irradiation Pulmonary Fibrosis
    Joel S Greenberger; Fiscal Year: 2012
    ..by TGF2-mediated migration and proliferation of bone marrow origin myofibroblast progenitor cells (bone marrow stromal cells/mesenchymal stem cells), which contribute to pulmonary fibrosis...
  9. Mechanisms of Airway Smooth Muscle Hypertrophy
    Marc B Hershenson; Fiscal Year: 2013
    ..We have isolated mesenchymal stromal cells from the tracheal aspirates of premature infants...
  10. Signal Transduction Mechanism of Osteoclast Differentiation
    Nandini Ghosh-Choudhury; Fiscal Year: 2013
    ..Recent reports suggest that BMPs act on osteoclasts indirectly through osteoblasts or stromal cells. The precise mechanism by which BMP type 2 (BMP-2) regulates the osteoclast activity is the key question in ..
  11. The molecular mechanism of Aire: partnering with DNA-PK
    Diane J Mathis; Fiscal Year: 2013
    ..Studies on this model revealed Aire to operate primarily within a rare population of thymic stromal cells by inducing the expression of a large repertoire of peripheral-tissue antigens, or PTAs...
  12. Stem Cell Based Therapy For Radiation Induced Gastrointestinal Syndrome
    Chandan Guha; Fiscal Year: 2010
    ..These stromal cells provide the niche and could supply critical growth factor/signals for ISC regeneration...
  13. Inflammation and Repair in Cardiac Ischemia-Reperfusion
    Lewis C Becker; Fiscal Year: 2011
    ..adenoviral vectors, transfection of decoy oligonucleotides or interfering RNAs, use of bone marrow derived stromal cells, and use of mice with targeted genetic mutations...
  14. Towards Induction of Cell Transplant Tolerance
    Lina Lu; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The role of tissue stromal cells as a scaffold for parenchymal cells is well known, however growing evidence supports their role as ..
  15. Role of AIB1 in malignant progression
    Anna Tate Riegel; Fiscal Year: 2013
    ..crosstalk are impacted by AIB1 effects on signaling in the tumor epithelial as well as the tumor stromal cells. We also propose that the ?3 splice isoform of AIB1 plays a distinct role in epithelial control of stromal ..
  16. Mechanisms mediating hematopoietic stem and progenitor cell trafficking
    Paul S Frenette; Fiscal Year: 2013
    ..release of noradrenaline emanating from SNS nerve terminals in the BM whose signals are transmitted into stromal cells through the b3 adrenergic receptor...
  17. A Novel Target for the Treatment of Endometriosis
    Paul D Crowe; Fiscal Year: 2011
    ..receptor antagonists inhibit steroidogenic gene expression and estrogen synthesis in cultured endometriotic stromal cells;in parallel, we will measure steroid synthesis in human primary adrenal cultures, where the receptor is also ..
  18. ROS, Redox Regulation and Novel Targets for Cancer Therapy
    Peng Huang; Fiscal Year: 2013
    ..We also found that that were highly dependent on the bone marrow stromal cells to alleviate the oxidative stress and promote their survival and drug resistance through enhancing GSH ..
  19. Cytotoxic-T-Lymphocyte (CTL) Therapy of AML
    Bruce R Blazar; Fiscal Year: 2013
    ..Markedly diminished expression of T- and B-cell chemokines (CCL19, 21, CXCL13) and LN stromal cells depletion;4...
  20. Regulation of Organized Intestinal Lymphoid Tissues by TRANCE/RANKL
    Ifor R Williams; Fiscal Year: 2012
    ..thymic epithelial cells, the differentiation of osteoclasts, and mammary gland lactation, is also present on stromal cells in ILF and PP...
  21. Role of Tumor and Stromal Cell Metabolism in Stress Adaptation and Progression
    EILEEN contact WHITE; Fiscal Year: 2010
    ..How tumor and associated stromal cells respond to this stress effects tumor progression and treatment response...
  22. Roles of Gs Alpha and interaction with Wnt signaling in regulation of adipocyte d
    Partha S Sinha; Fiscal Year: 2011
    ..Elucidation of the mechanisms governing how bone marrow stromal cells differentiate into adipocytes and osteoblasts may carry implications for metabolic diseases such as obesity ..
  23. Role of Gsalpha in Regulating Osteoblast Differentiation
    JOY Y WU; Fiscal Year: 2012
    ..will be assessed in vivo using in situ hybridization, and in vitro by culturing bone marrow stromal cells from wild-type and BGsaKO mice under osteogenic conditions...
  24. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2013
    ..between IFrag- /- and RAG-/- mice revealed that IFNAR expression is required on hematopoietic cells but not on stromal cells in order to maintain hematopoiesis during PC lung infection...
  25. Role of Interleukin-1 in mediating epithelial-dendritic cell crosstalk in the lun
    BART N contact LAMBRECHT; Fiscal Year: 2010
    ..How exactly IL-1 production and signaling is involved in causing allergic disease. Both hematopoietic and stromal cells can produce IL1[unreadable] and respond to it...
  26. REGULATION OF STROMAL WOUND HEALING BY GROWTH FACTORS
    GREGORY SCOTT SCHULTZ; Fiscal Year: 2012
    ..wound healing using CTGF promoter-GFP transgenic mice and Q-RT-PCR analysis of samples of epithelial cells, stromal cells and endothelial cells...
  27. Targeting Akt Activation in CLL
    Wei Ding; Fiscal Year: 2013
    ..stromal cell proliferation and subsequent vascular endothelial growth factor (VEGF) production in marrow stromal cells (MSC) through a PI3K/Akt signal activation pathway...
  28. Vaccines to promote Tc-1-based targeting of tumor stroma
    Walter J Storkus; Fiscal Year: 2013
    ..b>Stromal cells include vascular endothelial cells and pericytes that are required for the construction and maintenance of the ..
  29. Innate and Adaptive Immune Mechanisms in Arthritis
    RICHARD J BUCALA; Fiscal Year: 2013
    ..The expression of CD44 splice variants in T cells is associated with an enhanced trafficking response;and in stromal cells, with an increase in invasive phenotype...
  30. Liver Tissue Engineering Through Three-Dimensional Hepatocyte Culture
    Tammy T Chang; Fiscal Year: 2013
    ..This proposal builds upon those findings and aims to define the role of matrix and stromal cells in maintaining hepatocyte functions and to determine the underlying mechanisms...
  31. Steroid regulation of glucose utilization during early pregnancy.
    ANTONINA I FROLOVA; Fiscal Year: 2010
    ..estrogen-mediated, insulin-independent changes in glucose uptake and metabolism in 1) the murine endometrial stromal cells and 2) embryo at the time of implantation...
  32. Growth factors and engineered stroma for hematopoietic stem csll (HSC) expansion
    Harvey F Lodish; Fiscal Year: 2010
    ..applicant): Hematopoietic stem cells (HSCs) reside in specialized niches and receive signals from surrounding stromal cells, but their identities and the effects they have on HSCs are largely unknown...
  33. Regulation of Genomic Instability in Early Breast Cancer
    Thea D Tlsty; Fiscal Year: 2013
    ..we hypothesized that cells in this epigenetically-plastic state could be programmed by signals from stromal cells within the microenvironment to acquire epigenetic changes that promote tumorigenesis...
  34. ELUCIDATING THE FUNCTION OF MATRIPTASE-ACTIVATED PDGF D IN BONE METASTATIC PROSTA
    ABDO JAMAL NAJY; Fiscal Year: 2012
    ..The released active form of PDGF D binds to and activates its cognate receptor on surrounding stromal cells. Objective/Hypothesis: Both PDGF D and PDGFRBeta are upregulated within prostate cancer metastasis...
  35. Technology platform for development of multi-component preservation solution
    Allison Hubel; Fiscal Year: 2013
    ..Mesenchymal stem/stromal cells (MSCs) are being investigated for a variety of applications...
  36. Microvesicle Dynamics in B-Cell Chronic Lymphocytic Leukemia Tumor Microenvironme
    ASISH KUMAR GHOSH; Fiscal Year: 2013
    ..cells are biologically active as a result of their ability to have both intimate and remote influences on hos stromal cells. Recently, we discovered circulating MV from B-Cell Chronic Lymphocytic Leukemia plasma are unique mediators ..
  37. MOLECULAR MANIPULATION TO ENHANCE ANTI-MYELOMA RESPONSE
    Nikhil C Munshi; Fiscal Year: 2013
    ..hypothesize that conditions generated in BM microenvironment by interaction between MM cells and bone marrow stromal cells (BMSC) modulate the immune responses to support tumor progression in MGUS and in MM and targeting these ..
  38. ADULT STEM CELL SUPPRESSION DUE TO ALCOHOL INDUCED MICROENVIRONMENT ALTERATIONS
    Mandi J Lopez; Fiscal Year: 2010
    ..Adipose tissue-derived stromal cells (ASCs) promote osteogenesis both in vivo and in vitro...
  39. Mechanisms of adhesion and growth control in stem cells
    Reuben Kapur; Fiscal Year: 2010
    ..The BM microenvironment consists of extracellular matrix proteins as well as cells such as osteoblasts and stromal cells which contribute to the stem/progenitor cell fate by anchoring these cells in the BM cavity and delivering ..
  40. Environmental PPAR Agonists Accelerate Aging of Bone and Impair Lymphopoiesis
    AMELIA RACHEL HAAS BAKER; Fiscal Year: 2013
    ..Our data indicate that TBT is a highly potent activator of PPAR( in bone marrow stromal cells. The EC50 for adipocyte differentiation is ~10 nM, a concentration well within the range of organotins ..
  41. Developmental Exposure to Low-dose Bisphenol A and Human Prostate Cancer Suscepti
    Kevin P White; Fiscal Year: 2010
    ..progenitor cells using two model systems: 1) a 3-D co-culture system with human primary prostate epithelial/stromal cells to form prostaspheres in vitro, and 2) as recombinants with rat urogenital sinus mesenchyme grafted to murine ..
  42. Stat5b in Lymphomagenesis: Mechanistic and Therapeutic Implications
    John A Kelly; Fiscal Year: 2012
    ..Enriched immature populations will be cultured with stromal cells expressing the Notch delta like ligand (OP9-DL1) along with cytokines (IL-7), and growth factors (stem cell ..
  43. Identification of Biomechanically Valid Cell Therapeutics for Vocal Fold Scar
    Rebecca S Bartlett; Fiscal Year: 2013
    ..Candidate cell sources include mesenchymal stromal cells derived from either bone marrow (BM-MSC) or adipose tissue (AT-MSC)...
  44. Inflammatory Control of Lymphocyte Trafficking
    Sharon S Evans; Fiscal Year: 2013
    ..chimeras with wild-type and IL-6-deficient mice will segregate whether IL-6 production by radiation-resistant stromal cells or radiation-sensitive hematopoietic cells is required for enhanced lymphocyte trafficking across vessel walls ..
  45. Direct and Bone-Marrow Mediated Effects of Adipose Stem Cells in Emphysema
    Irina Petrache; Fiscal Year: 2013
    ..We demonstrated that pluripotent cells contained in adipose stroma, called adipose stem or stromal cells promote capillary growth and limit ischemic tissue damage in models of acute skeletal muscle, myocardial, and ..
  46. Multifunctional Printed Scaffolds for Enhancing Hepatocyte Viability and Function
    Ramille N Shah; Fiscal Year: 2013
    ..for growth factor delivery via self-assembling peptide amphiphile (PA) nanofibers~ and 3) co-culturing stromal cells and hepatocytes with 3D spatial control...
  47. Structural microenvironment of bone marrow stem cells
    FRANCESCO B RAMIREZ; Fiscal Year: 2013
    ..in coordinating MSC-supported HSC differentiation using mice with conditional Fbn1 inactivation in a specific stromal cells population...
  48. Treatment of Osteoradionecrosis with Bone Marrow Stromal Cells
    Sunday O Akintoye; Fiscal Year: 2010
    ..These data will provide substantial new insights. Dr. Akintoye's long term goal is to ultimately translate these into human clinical protocols to treat patients with osteoradionecrosis. ..
  49. Intratumoral genetic therapy for lung cancer
    Steven M Dubinett; Fiscal Year: 2013
    ..expressed by high endothelial venules in lymph nodes and Peyer's patches and by lymphatic vessels, stromal cells in the spleen and appendix...
  50. Uterine-specific genetic modification and lymphangioleiomyomatosis
    JOSE M TEIXEIRA; Fiscal Year: 2012
    ..the bipotential mammalian embryo not found in males, suggesting that the hormonally responsive mesenchymal stromal cells of the uterus might be the source of the cells for pulmonary fibrosis and account for the female-specificity ..
  51. LPL-Deficient Cats-A Quantitative Model of Gene Delivery
    PHILIP RICHARD VULLIET; Fiscal Year: 2010
    ..This project will determine if allogeneic mesenchymal stromal cells (MSCs) expressing active LPL will correct this genetic defect...
  52. Molecular Control of MSC differentiation and Bone Formation by KDM4B
    Cun Yu Wang; Fiscal Year: 2013
    ..to understand how molecular and epigenetic mechanisms control osteogenic differentiation of mesenchymal stem/stromal cells (MSCs), osteoblast function, and bone formation...
  53. Corneal Stromal-Epithelial Interactions During Fibrosis and Regeneration
    James D Zieske; Fiscal Year: 2012
    ..upregulation in the epithelium is a key component in the stimulation of a fibrotic response in the stromal cells and (3) Activation of TGF-[unreadable]3 blunts this fibrotic response...
  54. Hypersensitivity of Multiple Myeloma Bone Disease to Vitamin D
    GARSON DAVID ROODMAN; Fiscal Year: 2013
    ..AIM 1 will investigate the biological responses of myeloma &marrow stromal cells to low concentrations of 1,25-(OH)2D by assaying MM cell proliferation, MM-stromal cell adhesion, cytokine ..
  55. Epigenetic Modulation of PTPG by Zeranol in Beef Increases Breast Cancer Risk
    Young C Lin; Fiscal Year: 2010
    ..Define epigenetic and gene expression alterations in primary cultured normal human breast epithelial cells, stromal cells, and tissues exposed to serum and meat extracts collected from Zimplanted beef heifers...
  56. PDGF D AND PROSTATE CANCER BONE METASTASIS
    Hyeong Reh Choi Kim; Fiscal Year: 2013
    ..PDGF D, activated by the transmembrane serine protease matriptase, induces paracrine cell signaling in bone stromal cells, mediating tumor-stromal interactions critical for prostate carcinoma growth in the bone microenvironment...
  57. DLGH1 AND UROGENITAL DEVELOPMENT
    WOJCIECH A SWAT; Fiscal Year: 2012
    ..In addition, ureteric stromal cells, which normally lie between the urothelium and the smooth muscle layers and express Raldh2, are absent from ..
  58. Role of macrophages in MSC-mediated recovery of hematopoiesis after irradiation
    Manoj M Pillai; Fiscal Year: 2010
    ..macrophages are required for the tissue regeneration that is reported following injection of Mesenchymal Stromal Cells (MSC)...
  59. Role of estrogen receptor in endometrial cancer initiation and progression
    Sanaz Memarzadeh; Fiscal Year: 2013
    ..Retroviral delivery vectors will be used for the expression of candidate growth factors in endometrial stromal cells. Growth factor expressing stromal cells will be recombined with adult dissociated endometrial epithelia and ..
  60. The Role of the Stem Cell Niche in ALL
    Laura F Gibson; Fiscal Year: 2013
    ..In the current study we investigate the interaction of LSC with bone marrow stromal cells (BMSC) and the mechanisms by which BMSC contribute to maintenance of the LSC phenotype...
  61. Cytokine Enhancement of Myeloid Progenitor Cell Survival
    Hal E Broxmeyer; Fiscal Year: 2013
    ..mass, morphology, and DNA content, reactive oxygen species (ROS), and growth factor combinations, as well as stromal cells. Our long term goals are to elucidate a mechanistic role for mitochondria in HSC/HPC function, after ..
  62. Intracellular trafficking of Bisphosphonates in bone mesenchymal Stem Cells
    Sunday O Akintoye; Fiscal Year: 2013
    ..We have shown that orofacial bone marrow stromal cells or bone mesenchymal stem cells (BMSCs) from neural crest-derived maxilla/mandible (OFMSCs) are highly ..
  63. Treatment of glucocorticoid-induced osteonecrosis with nano-fullerenes
    Quanjun Cui; Fiscal Year: 2013
    ..of nano-fullerenes against dexamethasone (DEX)- induced adipogenesis and apoptosis in rabbit bone marrow stromal cells in vitro. 2...
  64. CELL AND GENE THERAPY IN A MOUSE MODEL OF HUMAN OSTEOGEN
    Christopher Niyibizi; Fiscal Year: 2000
    ..the feasibility of reversing OI defects by bone marrow stromal cell transplantation or by use of bone marrow stromal cells to deliver therapeutic genes to bone...
  65. Imaging evidence: Is there competition between marrow fat and bone?
    Wei Shen; Fiscal Year: 2010
    ..It is unknown whether this inverse relationship represents a preferential differentiation of stromal cells from osteoblasts to adipocytes, or a passive accumulation of fat as bone is lost and marrow space increases ..
  66. Matrix Metalloproteases Regulate Mesenchymal Stem Cells
    Zena Werb; Fiscal Year: 2006
    ..MSC give rise to both bone marrow stromal cells, which regulate the bone marrow microenvironment by providing factors such as Kit ligand, that required for ..
  67. The Role of the Microenvironment in Early Ovarian Cancer Metastasis
    HILARY ANN KENNY; Fiscal Year: 2010
    ..of a layer of mesothelial cells covering the underlying stroma composed of extra-cellular matrices (ECMs) and stromal cells (i.e. fibroblasts and adipocytes). Adipocytes are the main cell type (over 80%) present in omentum ...
  68. EVALUATION OF CELLULAR GENE THERAPY FOR OI
    Christopher Niyibizi; Fiscal Year: 2001
    ..The aims are: (1) to evaluate the potential of bone marrow stromal cells from normal donor mice transplanted into syngeneic OI mice to engraft, synthesize and deposit normal type I ..
  69. Hemophilia A: Intrathymic Delivery for Tolerance and Longterm Expression of FVIII
    William Raschke; Fiscal Year: 2007
    ..Intrathymic injection of lentiviral vectors efficiently transduces the long-lived thymic stromal cells, which are the target cell types for sustained hFVIII protein production...
  70. THYMIC LYMPHOCYTE DEVELOPMENT
    Irving Weissman; Fiscal Year: 2004
    ..The stromal cells of the thymus that regulate this process are derived from all 3 tissue layers - endoderm, ectoderm, and ..
  71. Role of IGF-II in Human Trophoblast-Decidua Interactions
    Linda Giudice; Fiscal Year: 2006
    ..In addition, the investigators have pursued a global approach to gene profiling of human endometrial stromal cells during the process of decidualization in response to progesterone and to cAMP, and gene profiling of human ..