mast cells

Summary

Summary: Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.

Top Publications

  1. ncbi IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
    Jochen Schmitz
    Schering Plough Biopharma Formerly DNAX Research, Inc, 901 California Avenue, Palo Alto, California 94304, USA
    Immunity 23:479-90. 2005
  2. pmc IgE and mast cells in allergic disease
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, California, USA
    Nat Med 18:693-704. 2012
  3. pmc Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Nat Immunol 12:1035-44. 2011
  4. ncbi Mast cells in the development of adaptive immune responses
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nat Immunol 6:135-42. 2005
  5. ncbi Mast cells: a cellular link between autoantibodies and inflammatory arthritis
    David M Lee
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 297:1689-92. 2002
  6. ncbi Mast-cell infiltration of airway smooth muscle in asthma
    Christopher E Brightling
    Division of Respiratory Medicine, Institute for Lung Health, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, United Kingdom
    N Engl J Med 346:1699-705. 2002
  7. ncbi Mast cell-orchestrated immunity to pathogens
    Soman N Abraham
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Immunol 10:440-52. 2010
  8. ncbi Mast cells as sensors of cell injury through IL-33 recognition
    Mattias Enoksson
    Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska Institute, SE 171 76 Stockholm, Sweden
    J Immunol 186:2523-8. 2011
  9. ncbi Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens
    Anne Dudeck
    Institute for Immunology, University of Technology Dresden, Medical Faculty Carl Gustav Carus, 01307 Dresden, Germany
    Immunity 34:973-84. 2011
  10. pmc The cytokine interleukin-33 mediates anaphylactic shock
    Peter N Pushparaj
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Scotland, United Kingdom
    Proc Natl Acad Sci U S A 106:9773-8. 2009

Detail Information

Publications369 found, 100 shown here

  1. ncbi IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
    Jochen Schmitz
    Schering Plough Biopharma Formerly DNAX Research, Inc, 901 California Avenue, Palo Alto, California 94304, USA
    Immunity 23:479-90. 2005
    ..In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs...
  2. pmc IgE and mast cells in allergic disease
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, California, USA
    Nat Med 18:693-704. 2012
    Immunoglobulin E (IgE) antibodies and mast cells have been so convincingly linked to the pathophysiology of anaphylaxis and other acute allergic reactions that it can be difficult to think of them in other contexts...
  3. pmc Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Nat Immunol 12:1035-44. 2011
    ..in three lineages of myeloid cells with important roles in innate and acquired immunity: macrophages, mast cells and neutrophils...
  4. ncbi Mast cells in the development of adaptive immune responses
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nat Immunol 6:135-42. 2005
    b>Mast cells are so widely recognized as critical effector cells in allergic disorders and other immunoglobulin E-associated acquired immune responses that it can be difficult to think of them in any other context...
  5. ncbi Mast cells: a cellular link between autoantibodies and inflammatory arthritis
    David M Lee
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 297:1689-92. 2002
    ..We find that two strains of mice deficient in mast cells, W/Wv and Sl/Sld, were resistant to development of joint inflammation and that susceptibility was restored in ..
  6. ncbi Mast-cell infiltration of airway smooth muscle in asthma
    Christopher E Brightling
    Division of Respiratory Medicine, Institute for Lung Health, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, United Kingdom
    N Engl J Med 346:1699-705. 2002
    ..We tested the hypothesis that there were differences between the two conditions in the microlocalization of mast cells within the airway smooth muscle.
  7. ncbi Mast cell-orchestrated immunity to pathogens
    Soman N Abraham
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Immunol 10:440-52. 2010
    Although mast cells were discovered more than a century ago, their functions beyond their role in allergic responses remained elusive until recently...
  8. ncbi Mast cells as sensors of cell injury through IL-33 recognition
    Mattias Enoksson
    Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska Institute, SE 171 76 Stockholm, Sweden
    J Immunol 186:2523-8. 2011
    ..In this study, we demonstrate that mast cells, potent promoters of acute inflammation, play a key role in responding to cell injury by recognizing IL-33 ..
  9. ncbi Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens
    Anne Dudeck
    Institute for Immunology, University of Technology Dresden, Medical Faculty Carl Gustav Carus, 01307 Dresden, Germany
    Immunity 34:973-84. 2011
    ..reporter mice for intravital imaging and showed that these adjuvant effects of contact allergens are mediated by mast cells and histamine...
  10. pmc The cytokine interleukin-33 mediates anaphylactic shock
    Peter N Pushparaj
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Scotland, United Kingdom
    Proc Natl Acad Sci U S A 106:9773-8. 2009
    ..In vitro, IL-33 directly induced degranulation, strong eicosanoid and cytokine production in IgE-sensitized mast cells. The molecular mechanisms triggering these responses include the activation of phospholipase D1 and sphingosine ..
  11. ncbi Disease-associated functions of IL-33: the new kid in the IL-1 family
    Foo Y Liew
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
    Nat Rev Immunol 10:103-10. 2010
    ..ST2 and IL-1 receptor accessory protein, is also widely expressed, particularly by T helper 2 (T(H)2) cells and mast cells. IL-33 is host-protective against helminth infection and reduces atherosclerosis by promoting T(H)2-type immune ..
  12. pmc Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo
    Michele A Grimbaldeston
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Am J Pathol 167:835-48. 2005
    ..in Kit(W/W-v) mice impair melanogenesis and result in anemia, sterility, and markedly reduced levels of tissue mast cells. In contrast, Kit(W-sh/W-sh) mice, bearing the W-sash (W(sh)) inversion mutation, have mast cell deficiency but ..
  13. pmc New developments in mast cell biology
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 9:1215-23. 2008
    b>Mast cells can function as effector and immunoregulatory cells in immunoglobulin E-associated allergic disorders, as well as in certain innate and adaptive immune responses...
  14. pmc Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis
    Andrew M Lin
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 187:490-500. 2011
    ..However, we demonstrate that mast cells and neutrophils, not T cells, are the predominant cell types that contain IL-17 in human skin...
  15. pmc Early weaning stress impairs development of mucosal barrier function in the porcine intestine
    Feli Smith
    Department of Population Health and Pathobiology, North Carolina State University, Raleigh, 27606, USA
    Am J Physiol Gastrointest Liver Physiol 298:G352-63. 2010
    ..in early-weaned pigs coincided with increased lamina propria immune cell density particularly mucosal mast cells. The mast cell stabilizer drug sodium cromoglycolate ameliorated barrier dysfunction and hypersecretion in early-..
  16. ncbi Widespread immunological functions of mast cells: fact or fiction?
    Hans Reimer Rodewald
    Division for Cellular Immunology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, Heidelberg, Germany
    Immunity 37:13-24. 2012
    Immunological functions of mast cells are currently considered to be much broader than the original role of mast cells in IgE-driven allergic disease...
  17. ncbi Mast cells--key effector cells in immune responses
    Martin Metz
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    Trends Immunol 28:234-41. 2007
    b>Mast cells are best known for their potent effector functions in allergic disorders...
  18. ncbi Mast cells as sentinels of innate immunity
    S J Galli
    Department of Pathology Division of Experimental Pathology, Research North Building, Beth Israel Deaconess Medical Center East, Boston, MA 02215, USA
    Curr Opin Immunol 11:53-9. 1999
    b>Mast cells are widely regarded as important effector cells in immune responses associated with Th2 cells and IgE...
  19. pmc Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis
    L M Coussens
    Hormone Research Institute, University of California, San Francisco San Francisco, California 94143 0534, USA
    Genes Dev 13:1382-97. 1999
    ..We report that infiltration by mast cells and activation of the matrix metalloproteinase MMP-9/gelatinase B coincides with the angiogenic switch in ..
  20. pmc IL-33 exacerbates antigen-induced arthritis by activating mast cells
    Damo Xu
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G12 8TA, United Kingdom
    Proc Natl Acad Sci U S A 105:10913-8. 2008
    ..b>Mast cells expressed high levels of ST2 and responded directly to IL-33 to produce a spectrum of inflammatory cytokines and ..
  21. pmc IgE, mast cells, basophils, and eosinophils
    Kelly D Stone
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
    J Allergy Clin Immunol 125:S73-80. 2010
    IgE, mast cells, basophils, and eosinophils are essential components of allergic inflammation...
  22. ncbi Mast cells in atherosclerosis
    I Bot
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
    Thromb Haemost 106:820-6. 2011
    ..Upon activation mast cells release granules, which contain a large panel of mediators, including neutral proteases (e.g...
  23. ncbi Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients
    Girolamo Ranieri
    Department of Critical Area and Surery, National Cancer Institute Giovanni Paolo II, 70126 Bari, Italy
    Int J Oncol 35:115-20. 2009
    Literature data indicate that mast cells (MCs) are involved in tumor angiogenesis due to the release of several pro-angiogenetic factors among which tryptase, a serine protease stored in MCs granules, is one of the most active...
  24. pmc Mast cells and inflammation
    Theoharis C Theoharides
    Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, MA 02111, USA
    Biochim Biophys Acta 1822:21-33. 2012
    b>Mast cells are well known for their role in allergic and anaphylactic reactions, as well as their involvement in acquired and innate immunity...
  25. pmc IL-33 is produced by mast cells and regulates IgE-dependent inflammation
    Chia Lin Hsu
    Division of Allergy Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 5:e11944. 2010
    ..While IL-33 is constitutively expressed in endothelial and epithelial cells, where it may function as a transcriptional regulator, cellular sources of IL-33 and its role in inflammation remain unclear...
  26. ncbi Integrated signalling pathways for mast-cell activation
    Alasdair M Gilfillan
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11C206, 10 Center Drive, MSC 1881, Bethesda, Maryland 20892 1881, USA
    Nat Rev Immunol 6:218-30. 2006
    ..a physiological setting, other receptors, such as KIT, might also markedly influence the release of mediators by mast cells. Recent studies have provided evidence that FcepsilonRI-dependent degranulation is regulated by two ..
  27. pmc Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Eur J Immunol 40:1843-51. 2010
    b>Mast cells are widely distributed in tissues, particularly near surfaces exposed to the environment...
  28. ncbi Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI
    Arnold S Kirshenbaum
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
    Leuk Res 27:677-82. 2003
    ..LAD 1 and 2 cells have the ultrastructural features of human mast cells, and express FcepsilonRI, CD4, 9, 13, 14, 22, 31, 32, 45, 64, 71, 103, 117, 132, CXCR4 (CD184), CCR5 (CD195); ..
  29. ncbi Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cells
    David Moulin
    Division of Rheumatology, University Hospital, University of Geneva School of Medicine, 26 Avenue Beau Sejour, 1211, Geneva 14, Switzerland
    Cytokine 40:216-25. 2007
    ..In this study, we demonstrate that IL-33 induces the production of pro-inflammatory mediators in mast cells. IL-33 dose and time-dependently stimulated IL-6 secretion by P815 mastocytoma cells and primary mouse bone ..
  30. ncbi Mast cells as targets of corticotropin-releasing factor and related peptides
    Theoharis C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Trends Pharmacol Sci 25:563-8. 2004
    ..Recent evidence suggests that crosstalk between mast cells, neurons and keratinocytes might be involved in such exacerbation...
  31. ncbi Mast cells and cancer: enemies or allies?
    Grzegorz Dyduch
    Department of Pathomorphology, Jagiellonian University, Krakow, Poland
    Pol J Pathol 63:1-7. 2012
    b>Mast cells are a component of cancer microenvironment the role of which is complex and poorly understood. Mast cells promote cancer growth by stimulation of neoangiogenesis, tissue remodeling and by modulation of the host immune response...
  32. ncbi Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity
    Thorsten B Feyerabend
    Division for Cellular Immunology, Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Immunity 35:832-44. 2011
    Immunological functions of mast cells remain poorly understood. Studies in Kit mutant mice suggest key roles for mast cells in certain antibody- and T cell-mediated autoimmune diseases...
  33. pmc Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines
    Matthew R Hepworth
    Institute of Molecular Parasitology, Humboldt University of Berlin, D 10115 Berlin, Germany
    Proc Natl Acad Sci U S A 109:6644-9. 2012
    b>Mast cells (MCs) are potent inflammatory cells that are distributed throughout mucosal barrier tissues and respond rapidly to pathogenic stimuli. During helminth infections, MCs play an important role as late-stage effectors...
  34. ncbi Pathophysiology of allergic inflammation
    Peter J Barnes
    National Heart and Lung Institute, Imperial College, London, UK
    Immunol Rev 242:31-50. 2011
    Allergic inflammation is due to a complex interplay between several inflammatory cells, including mast cells, basophils, lymphocytes, dendritic cells, eosinophils, and sometimes neutrophils...
  35. ncbi Prostaglandin E2 promotes degranulation-independent release of MCP-1 from mast cells
    Takayuki Nakayama
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Leukoc Biol 79:95-104. 2006
    b>Mast cells (MCs) are common components of inflammatory infiltrates and a source of proangiogenic factors. Inflammation is often accompanied by vascular changes...
  36. pmc Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice
    Jennifer N Lilla
    Department of Pathology, Stanford University School of Medicine, CA 94305 5324, USA
    Blood 118:6930-8. 2011
    ..C57BL/6-Cpa3-Cre; Mcl-1(fl/fl) mice are severely deficient in mast cells (92%-100% reduced in various tissues analyzed) and also have a marked deficiency in basophils (58%-78% reduced ..
  37. ncbi Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs
    Adam J Moeser
    Center for Comparative Translational and Molecular Research, College of Veterinary Medicine, North Carolina State Univ, 4700 Hillsborough St, Raleigh, NC 27606, USA
    Am J Physiol Gastrointest Liver Physiol 293:G413-21. 2007
    ..to assess the impact of piglet age on weaning-associated intestinal dysfunction and to determine the role that mast cells play in weaning-induced breakdown of mucosal barrier function...
  38. pmc Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity
    Atsushi Otsuka
    Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 6:e25538. 2011
    The role of mast cells (MCs) in contact hypersensitivity (CHS) remains controversial...
  39. ncbi The role of mast cells in allergic inflammation
    Kawa Amin
    Department of Medical Science, Respiratory Medicine and Allergology, Clinical Chemistry and Asthma Research Centre, Uppsala University and University Hospital, Uppsala, Sweden
    Respir Med 106:9-14. 2012
    The histochemical characteristics of human basophils and tissue mast cells were described over a century ago by Paul Ehrlich...
  40. ncbi IL-33 synergizes with IgE-dependent and IgE-independent agents to promote mast cell and basophil activation
    Matthew R Silver
    Inflammation Research, Wyeth, 200 Cambridge Park Drive, Cambridge, MA, 02140, USA
    Inflamm Res 59:207-18. 2010
    ..Because IL-33 expression is inflammation inducible, we investigated IL-33-mediated effects in concert with both IgE-mediated and IgE-independent stimulation...
  41. ncbi Identification of proapoptotic Bim as a tumor suppressor in neoplastic mast cells: role of KIT D816V and effects of various targeted drugs
    Karl J Aichberger
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
    Blood 114:5342-51. 2009
    Systemic mastocytosis (SM) is a myeloid neoplasm involving mast cells (MCs) and their progenitors. In most cases, neoplastic cells display the D816V-mutated variant of KIT...
  42. ncbi Cordyceps militaris extract suppresses dextran sodium sulfate-induced acute colitis in mice and production of inflammatory mediators from macrophages and mast cells
    Eun Su Han
    Department of Bioscience and Biotechnology, Konkuk University, 1 Hwayang dong, Kwangjin gu, Seoul 143 701, Republic of Korea
    J Ethnopharmacol 134:703-10. 2011
    ..Cordyceps militaris is a well-known medicinal mushroom used for treatment of asthma, and other bronchial and lung inflammatory diseases...
  43. ncbi Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome
    Giovanni Barbara
    Department of Internal Medicine and Gastroenterology, and CRBA, University of Bologna, St Orsola Hospital, Via Massarenti 9, I 40138 Bologna, Italy
    Gastroenterology 132:26-37. 2007
    ..However, the underlying mechanisms remain unknown. We assessed the effect of mast cell mediators released from the colonic mucosa of IBS patients on the activation of rat sensory neurons in vitro...
  44. ncbi Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
    Giovanni Barbara
    Departmentof Internal Medicine and Gastroenterology, and CRBA, University of Bologna, Italy
    Gastroenterology 126:693-702. 2004
    ..We assessed colonic mast cell infiltration, mediator release, and spatial interactions with mucosal innervation and their correlation with abdominal pain in IBS patients...
  45. ncbi IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals
    Lien H Ho
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    J Leukoc Biol 82:1481-90. 2007
    ..molecules, IL-1 and IL-18, can promote Th2 cytokine production by IgE/antigen-FcepsilonRI-stimulated mouse mast cells. Another IL-1-related molecule, IL-33, was identified recently as a ligand for T1/ST2...
  46. ncbi Increase of mast cells and tumor angiogenesis in oral squamous cell carcinoma
    Anak Iamaroon
    Department of Odontology and Oral Pathology, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand 50200
    J Oral Pathol Med 32:195-9. 2003
    Although mast cells (MCs) have been implicated in promoting angiogenesis in some malignant tumors, especially of the aerodigestive tract, little is known in oral squamous cell carcinoma (SCC).
  47. pmc Human FcγRIIA induces anaphylactic and allergic reactions
    Friederike Jönsson
    Institut Pasteur, Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, Paris, France
    Blood 119:2533-44. 2012
    ..and IgG receptors (FcγRIIIA and FcγRIV) expressed by neutrophils, rather than on IgE and FcεRI expressed by mast cells and basophils...
  48. pmc Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells
    Zoulfia Allakhverdi
    Laboratory on Allergy, CHUM Research Center, Notre Dame Hospital, Montreal, Quebec H2L 4M1, Canada
    J Exp Med 204:253-8. 2007
    ..with interleukin 1 and tumor necrosis factor, stimulates the production of high levels of Th2 cytokines by human mast cells (MCs)...
  49. pmc Zinc is a novel intracellular second messenger
    Satoru Yamasaki
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
    J Cell Biol 177:637-45. 2007
    ..FcepsilonRI]) induced a release of free zinc from the perinuclear area, including the endoplasmic reticulum in mast cells, a phenomenon we call the zinc wave...
  50. ncbi Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites
    C S Lantz
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 392:90-3. 1998
    ..IL-3 may be particularly critical for the development, survival and function of tissue mast cells and blood basophils, which are thought to be important effector cells in immunity to parasites and other ..
  51. ncbi Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses
    Yoshihiro Baba
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, 1 7 22, Suehirocho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Nat Immunol 9:81-8. 2008
    b>Mast cells have key functions as effectors of immunoglobulin E-mediated allergic inflammatory diseases. Allergen stimulation induces Ca2+ influx and elicits the secretion of inflammatory mediators from mast cells...
  52. ncbi Mast cells express IL-17A in rheumatoid arthritis synovium
    Axel J Hueber
    Division of Infection, Immunity and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 184:3336-40. 2010
    ..Unexpectedly, the majority of IL-17A expression colocalized within mast cells. Furthermore, we demonstrated in vitro that mast cells produced RORC-dependent IL-17A upon stimulation with TNF-..
  53. pmc Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis
    V H Secor
    Graduate Program in Immunology and Molecular Pathogenesis, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Exp Med 191:813-22. 2000
    In addition to their well characterized role in allergic inflammation, recent data confirm that mast cells play a more extensive role in a variety of immune responses...
  54. pmc Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice
    Jian Liu
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 15:940-5. 2009
    ..This study presents evidence that mast cells also contribute to diet-induced obesity and diabetes...
  55. ncbi New and emerging roles for mast cells in host defence
    Wojciech Dawicki
    Dalhousie University, 5850 College Street, Halifax, Nova Scotia, B3H 1X5, Canada
    Curr Opin Immunol 19:31-8. 2007
    b>Mast cells are highly effective sentinel cells, found close to blood vessels and especially common sites of potential infection, such as the skin, airways and gastrointestinal tract...
  56. ncbi Crucial role for autophagy in degranulation of mast cells
    Hiroko Ushio
    Atopy Allergy Research Center, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    J Allergy Clin Immunol 127:1267-76.e6. 2011
    ..However, a role for autophagy in development and/or function of mast cells is unknown.
  57. ncbi Microglia and mast cells: two tracks on the road to neuroinflammation
    Stephen D Skaper
    Dipartimento di Scienze del Farmaco, University of Padova, Largo E Meneghetti 2, 35131 Padova, Italy
    FASEB J 26:3103-17. 2012
    ..b>Mast cells are of particular relevance in this context...
  58. ncbi Histamine H₄ receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation
    Pragnya Desai
    Johnson and Johnson Pharmaceutical Research and Development, LLC, San Diego, CA 92121, USA
    Eur J Immunol 41:1764-73. 2011
    ..Here it is shown that the receptor can mediate cytokine production from mast cells. Histamine and an H(4)R agonist, JNJ 28610244, induced the production of IL-6 in mouse bone marrow (BM)-derived ..
  59. ncbi Mast cells in human adipose tissue: link with morbid obesity, inflammatory status, and diabetes
    Adeline Divoux
    Institut National de la Santé et de la Recherche Médicale Unité 872, Nutriomique, and Université Pierre et Marie Curie Paris 6, Centre de Recherche des Cordeliers, Unité Mixte de Recherche UMR S872, F 75006 Paris, France
    J Clin Endocrinol Metab 97:E1677-85. 2012
    b>Mast cells are immune cells known for their role in several inflammatory and fibrotic diseases...
  60. ncbi Role of mast cells in tumor growth
    Pio Conti
    Immunology Division, Department of Oncology and Neuro science, University of Chieti, Via dei Vestini, 66100 Chieti, Italy
    Ann Clin Lab Sci 37:315-22. 2007
    ..Histopathologic studies show that many tumors are surrounded by mononuclear cell and mast cell infiltrates. Mast cells are ubiquitous in the body and are critical for allergic reactions...
  61. ncbi Mast cells, angiogenesis, and tumour growth
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, 70124 Bari, Italy
    Biochim Biophys Acta 1822:2-8. 2012
    Accumulation of mast cells (MCs) in tumours was described by Ehrlich in his doctoral thesis...
  62. ncbi Mast cell-mediated antigen presentation regulates CD8+ T cell effector functions
    Erietta Stelekati
    Department of Immunology and Cell Biology, Research Center Borstel, D 23845 Borstel, Germany
    Immunity 31:665-76. 2009
    The characteristics, importance, and molecular requirements for interactions between mast cells (MCs) and CD8(+) T cells have not been elucidated...
  63. ncbi Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection
    James B McLachlan
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Immunol 4:1199-205. 2003
    ..These results show a critical function for peripheral mast cell-derived tumor necrosis factor in regulating the hypertrophy of draining lymph nodes during infection...
  64. pmc Skin mast cells protect mice against vaccinia virus by triggering mast cell receptor S1PR2 and releasing antimicrobial peptides
    Zhenping Wang
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 188:345-57. 2012
    b>Mast cells (MCs) are well-known effectors of allergic reactions and are considered sentinels in the skin and mucosa. In addition, through their production of cathelicidin, MCs have the capacity to oppose invading pathogens...
  65. ncbi Mast cells as regulators of skin inflammation and immunity
    Ilkka T Harvima
    Department of Dermatology, University of Eastern Finland and Kuopio University Hospital, P O Box 1777, FIN 70210 Kuopio, Finland
    Acta Derm Venereol 91:644-50. 2011
    b>Mast cells are known to be the effector cells of immediate-type allergy, but experimental evidence obtained during the last decade has revealed their role in innate and acquired immunity...
  66. pmc Human mast cell degranulation and preformed TNF secretion require mitochondrial translocation to exocytosis sites: relevance to atopic dermatitis
    Bodi Zhang
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, MA 02111, USA
    J Allergy Clin Immunol 127:1522-31.e8. 2011
    b>Mast cells derive from hematopoietic cell precursors and participate in tissue allergic, immune, and inflammatory processes...
  67. pmc Mast cells mobilize myeloid-derived suppressor cells and Treg cells in tumor microenvironment via IL-17 pathway in murine hepatocarcinoma model
    Zhuoshun Yang
    Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, The People s Republic of China
    PLoS ONE 5:e8922. 2010
    ..We have demonstrated that mast cells are accumulated and exacerbate the inflammation and immunosuppression in tumor microenvironment via SCF/c-kit ..
  68. pmc Mast cells condition dendritic cells to mediate allograft tolerance
    Victor C de Vries
    Department of Microbiology and Immunology, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    Immunity 35:550-61. 2011
    Peripheral tolerance orchestrated by regulatory T cells, dendritic cells (DCs), and mast cells (MCs) has been studied in several models including skin allograft tolerance...
  69. pmc Crosstalk between mast cells and pancreatic cancer cells contributes to pancreatic tumor progression
    Matthew J Strouch
    Department of Surgery, The Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, and Jesse Brown VA Medical Center, Chicago, Illinois, USA
    Clin Cancer Res 16:2257-65. 2010
    To assess the clinical and pathologic significance of mast cell infiltration in human pancreatic cancer and evaluate crosstalk between mast cells and cancer cells in vitro.
  70. pmc Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance
    Ashley L St John
    Duke National University of Singapore, Singapore 169857
    Proc Natl Acad Sci U S A 108:9190-5. 2011
    A wealth of evidence supports the essential contributions of mast cells (MCs) to immune defense against bacteria and parasites; however, the role of MCs in viral infections has not been defined...
  71. ncbi Mast cells and angiogenesis
    Klas Norrby
    Department of Pathology, Sahlgrenska University Hospital, Goteborg, Sweden
    APMIS 110:355-71. 2002
    Angiogenesis is tightly regulated by pro- and anti-angiogenic factors. Secreting mast cells are able to induce and enhance angiogenesis via multiple in part interacting pathways...
  72. ncbi Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo
    Chris Oschatz
    Clinical Chemistry, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Immunity 34:258-68. 2011
    Activated mast cells trigger edema in allergic and inflammatory disease. We report a paracrine mechanism by which mast cell-released heparin increases vascular permeability in vivo...
  73. pmc IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin
    Theoharis C Theoharides
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, and Maternal Fetal Medicine, Tufts Medical Center, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 107:4448-53. 2010
    The peptide substance P (SP) has been implicated in inflammatory conditions, such as psoriasis, where mast cells and VEGF are increased...
  74. ncbi TLR3-induced activation of mast cells modulates CD8+ T-cell recruitment
    Zane Orinska
    Department of Immunology and Cellular Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Blood 106:978-87. 2005
    b>Mast cells play an important role in host defense against various pathogens, but their role in viral infection has not been clarified in detail...
  75. ncbi Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis
    Troy Noordenbos
    Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 64:99-109. 2012
    ..Recent observations have indicated a marked synovial mast cell infiltration in psoriatic SpA. We therefore undertook the present study to investigate the potential contribution of mast cells to synovial inflammation in SpA.
  76. ncbi Mast cells, angiogenesis and cancer
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare Bari, Italy
    Adv Exp Med Biol 716:270-88. 2011
    b>Mast cells (MCs) were first described by Paul Ehrlich 1 in his doctoral thesis. MCs have long been implicated in the pathogenesis of allergic reactions and certain protective responses to parasites...
  77. pmc Regulation of mast cell responses in health and disease
    Alasdair M Gilfillan
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
    Crit Rev Immunol 31:475-529. 2011
    b>Mast cells are multifunctional cells that initiate not only IgE-dependent allergic diseases but also play a fundamental role in innate and adaptive immune responses to microbial infection...
  78. ncbi Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases
    Jiro Kitaura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 174:4495-504. 2005
    b>Mast cells play a critical role in IgE-dependent immediate hypersensitivity...
  79. ncbi Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its proinflammatory effects
    T C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Endocrinology 139:403-13. 1998
    b>Mast cells are involved in atopic disorders, often exacerbated by stress, and are located perivascularly close to sympathetic and sensory nerve endings...
  80. ncbi Mast cells in the promotion and limitation of chronic inflammation
    Martin Metz
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Immunol Rev 217:304-28. 2007
    Observations of increased numbers of mast cells at sites of chronic inflammation have been reported for over a hundred years...
  81. pmc Mast cells and mastocytosis
    Dean D Metcalfe
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
    Blood 112:946-56. 2008
    b>Mast cells have been recognized for well over 100 years. With time, human mast cells have been documented to originate from CD34+ cells, and have been implicated in host responses in both innate and acquired immunity...
  82. pmc Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis
    Puneet S Jolly
    Department of Biochemistry, Virginia Commonwealth University Medical Center, Richmond 23298, USA
    J Exp Med 199:959-70. 2004
    b>Mast cells secrete various substances that initiate and perpetuate allergic responses...
  83. pmc Mitochondrial DNA and anti-mitochondrial antibodies in serum of autistic children
    Bodi Zhang
    Laboratory of Molecular Immunopharmacology and Drug Discovery, Tufts University School of Medicine, Boston, MA, USA
    J Neuroinflammation 7:80. 2010
    ..001) as compared to normally developing, unrelated controls (n = 12). Extracellular blood mtDNA and other components may characterize an autistic endophenotype and may contribute to its pathogenesis by activating autoimmune responses...
  84. pmc Mast cells in atopic dermatitis
    Toshiaki Kawakami
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Curr Opin Immunol 21:666-78. 2009
    b>Mast cells play as the major effector cells in immediate hypersensitivity through activation via the high-affinity IgE receptor, Fc epsilon RI, although many other functions have recently been discovered for this cell type...
  85. ncbi Critical role of mast cells in inflammatory diseases and the effect of acute stress
    Theoharis C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts New England Medical Center, Boston, MA, USA
    J Neuroimmunol 146:1-12. 2004
    b>Mast cells are not only necessary for allergic reactions, but recent findings indicate that they are also involved in a variety of neuroinflammatory diseases, especially those worsened by stress...
  86. ncbi Roles of mast cells and basophils in innate and acquired immunity
    J Wedemeyer
    Department of Pathology, L 235, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Curr Opin Immunol 12:624-31. 2000
    There have been several recent advances in knowledge about mast cells and basophils in immune responses, of which some are particularly important: a role has been found for heparin in the storage of certain proteases and other mediators ..
  87. ncbi Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice
    Taro Fukao
    Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nat Immunol 3:295-304. 2002
    ..regulatory subunit of phosphatidylinositol-3 kinase (PI3K) are deficient in gastrointestinal and peritoneal mast cells but have dermal mast cells...
  88. pmc The prognostic relevance of angiogenesis and mast cells in squamous cell carcinoma of the oesophagus
    G O Elpek
    Department of Pathology, Akdeniz University, Medical School, Dekanlik, 07070 Antalya, Turkey
    J Clin Pathol 54:940-4. 2001
    ..Among the host immune cells, a role has been implicated for mast cells in tumour progression via promoting angiogenesis...
  89. ncbi Murine mast cells secrete a unique profile of cytokines and prostaglandins in response to distinct TLR2 ligands
    Salima Mrabet-Dahbi
    Allergie Centrum Charité, Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Exp Dermatol 18:437-44. 2009
    b>Mast cells (MCs) are important effector cells in host defense against bacteria. In the course of a bacterial infection, MCs can be activated by various mechanisms, i.e...
  90. ncbi Mast cells and cutaneous malignancies
    Sydney Ch'ng
    Wellington Regional Plastic, Maxillofacial and Burns Unit, Hutt Hospital, Wellington, New Zealand
    Mod Pathol 19:149-59. 2006
    This paper reviews the role of mast cells in the development and progression of basal cell carcinoma, squamous cell carcinoma and malignant melanoma. Mast cells accumulate around cutaneous malignancies...
  91. pmc Our perception of the mast cell from Paul Ehrlich to now
    Michael A Beaven
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Eur J Immunol 39:11-25. 2009
    ..In addition, the responsiveness of mast cells to immunological and pathological stimulants is highly modulated by the tissue cytokine environment and by ..
  92. ncbi Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data
    Stephan C Bischoff
    Department of Nutritional Medicine and Immunology, University of Hohenheim, Fruwirthstr 12, D 70593 Stuttgart, Germany
    Nat Rev Immunol 7:93-104. 2007
    The versatile role of mast cells in allergy, in innate immune responses and in the regulation of tissue homeostasis is well recognized...
  93. ncbi The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Italy
    Pain 139:541-50. 2008
    ..In addition, the hypothesis that PEA might act through the modulation of local mast cells degranulation is sustained by our findings showing that PEA significantly reduced the production of many ..
  94. ncbi The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations
    Yongsheng Ma
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Blood 99:1741-4. 2002
    ..Furthermore, these results help establish a general paradigm whereby classification of mutations affecting oncogenic enzymes as RT or EST may be useful in predicting tumor sensitivity or resistance to inhibitory drugs...
  95. ncbi Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival
    J Kalesnikoff
    The Terry Fox Laboratory, British Columbia Cancer Agency, 601 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    Immunity 14:801-11. 2001
    Although IgE binding to mast cells is thought to be a passive presensitization step, we demonstrate herein that monomeric IgE (mIgE) in the absence of antigen (Ag) stimulates multiple phosphorylation events in normal murine bone marrow-..
  96. ncbi Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation
    Maren von Köckritz-Blickwede
    Infection Immunology Research Group, Helmholtz Center for Infection Research, Braunschweig, Germany
    Blood 111:3070-80. 2008
    These days it has been increasingly recognized that mast cells (MCs) are critical components of host defense against pathogens...
  97. ncbi Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha
    R Malaviya
    Department of Pathology, Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    Nature 381:77-80. 1996
    Although mast cells have been implicated in a variety of inflammatory conditions including immediate hypersensitivity and interstitial cystitis, their physiological role in the body is unknown...
  98. ncbi R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation
    Sylvia Braselmann
    Rigel Pharmaceuticals, South San Francisco, CA 94080, USA
    J Pharmacol Exp Ther 319:998-1008. 2006
    ..Using cell-based structure activity relationships with cultured human mast cells, we have identified the small molecule R406 [N4-(2,2-dimethyl-3-oxo-4H-pyrid[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-..
  99. ncbi IL-33 can promote survival, adhesion and cytokine production in human mast cells
    Motoyasu Iikura
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Lab Invest 87:971-8. 2007
    ..receptor, T1/ST2/IL-1R4, and can promote cytokine secretion by Th2 cells and NF-kappaB phosphorylation in mouse mast cells. However, the effects of these molecules, especially IL-33, in human mast cells are poorly understood...
  100. ncbi Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma
    Davinder Kaur
    Institute for Lung Health, and Department of Infection, Inflammation and Immunity, University of Leicester, Leicester, United Kingdom
    Am J Respir Crit Care Med 174:1179-88. 2006
    ..We hypothesized that this results from migration of ASM or progenitors in response to chemokines derived from ASM or mast cells within the ASM bundle.
  101. ncbi Mast cells: the Jekyll and Hyde of tumor growth
    Theoharis C Theoharides
    Departments of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and New England Medical Center, 136 Harrison Avenue, Boston, MA 02111, USA
    Trends Immunol 25:235-41. 2004

Research Grants75

  1. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..Degranulation of resident mast cells is an early event in I/R and results in chymase release into the interstitium (8- 10)...
  2. Mapping for Specialized Domains for FCeRI Signaling &Internalization
    Bridget S Wilson; Fiscal Year: 2013
    ..Public Health Relevance: Allergic diseases are on the rise in the United States. Mast cells and basophils are the principal mediators of the allergic response, through activation of the high affinity IgE ..
  3. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
    ..Neuroimmune interactions in CFS are still unknown creating a vacuum in diagnosis and treatment. Mast cells and their mediators have been implicated in all diseases that are comorbid with CFS...
  4. Targeting Galectin-3 with novel drugs for treatment of eczema
    Fu Tong Liu; Fiscal Year: 2010
    ..complex disease, involving multiple immunologic and inflammatory pathways that include T cells, dendritic cells, mast cells and eosinophils, as well as keratinocytes...
  5. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
    ..by airway hyperreactivity (AHR), inflammatory infiltrates containing eosinophilic leukocytes, lymphocytes, and mast cells, increased mucus secretion, and elevated serum IgE levels...
  6. The Kallikrein/Kinin-Mast Cell Interaction in Volume Overload
    CHIH CHANG KEVIN WEI; Fiscal Year: 2013
    ..In addition to its antifibrotic effect, BK is chemotactic for inflammatory cells, in particular mast cells (MCs), which are the source of the serine protease chymase...
  7. Bi-functional Therapeutics for Allergy-BFTA
    Swey Shen Chen; Fiscal Year: 2010
    ..i) Immune complexes formed by IgE and anti-C(2-3L are safely sequestered from binding to Fc(RI( receptors on mast cells/basophils, and are removed from the circulation and mucosal compartments...
  8. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010
    ..many essential cells of the host immune response, including T and B cells, macrophages, dendritic cells, PMNs, mast cells, and natural killer cells...
  9. Histamine modulation of biliary proliferation and damage
    Heather L Francis; Fiscal Year: 2013
    ..In addition to cholangiocytes, histamine is synthesized mainly from mast cells in response to many pathologies and inflammatory diseases. After release histamine is quickly stored or degraded...
  10. Mechanisms Regulating Reduced c-Kit-Dependent EAE Susceptibility in Male SJL Mice
    MELISSA ANN BROWN; Fiscal Year: 2013
    ..b>Mast cells are granulocytes that reside in most tissues and are among the innate cells that exert an important amplifying ..
  11. Hematopoietic Stem Cell Transplantation in Osteogenesis Imperfecta
    Meenal Mehrotra; Fiscal Year: 2012
    ..e. HSCs produce blood cells and few other cells like mast cells and osteoclasts, while MSCs generate a number of mesenchymal cells including fibroblasts, adipocytes, ..
  12. Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
    LAURA ELISE CROTTY ALEXANDER; Fiscal Year: 2013
    ..Dendritic cells, eosinophils, and mast cells are known to play a role in the development and progression of asthma, however the molecular mechanisms behind ..
  13. Sphingosine 1-phosphate and cardioprotection
    JOEL SAMUEL KARLINER; Fiscal Year: 2012
    ..S1P is a lysophospholipid produced by mast cells, erythrocytes, platelets, cardiac myocytes, and other cell types in de novo biosynthetic pathways and by ..
  14. Surveillance of Serum Contents by Mast Cells and Regulation of Allergic Immunity
    Laurence E Cheng; Fiscal Year: 2013
    ..b>Mast cells play a central role in the clinical expression of allergic disease, largely by acquiring the capacity to respond ..
  15. Modulation of Colonic Epithelial Permeability by Sex Hormones
    Muriel Larauche; Fiscal Year: 2013
    ..In women with IBS, a higher number of activated mast cells are present than in men with IBS...
  16. Cellular interactions in asthma
    CHRISTOPHER DAVID CABALLERO ALLEN; Fiscal Year: 2012
    ..The particular cell types of interest will be mast cells, basophils, eosinophils, neutrophils, macrophages, monocytes, dendritic cells, T cells, and B cells...
  17. Targeting Siglec-8/-F to treat eosinophil and mast cell related disorders
    Bruce S Bochner; Fiscal Year: 2013
    ..by applicant): In anaphylaxis, asthma and other forms of acute and chronic allergic diseases, eosinophils and mast cells, through release of preformed and newly generated mediators, granule proteins, and cytokines, are felt to be key ..
  18. Targeting Siglec-8/-F to treat eosinophil and mast cell related disorders
    Bruce S Bochner; Fiscal Year: 2012
    ..by applicant): In anaphylaxis, asthma and other forms of acute and chronic allergic diseases, eosinophils and mast cells, through release of preformed and newly generated mediators, granule proteins, and cytokines, are felt to be key ..
  19. IMMUNOLOGIC BASIS OF RESISTANCE AND HYPERSENSITIVITY
    KARL FRANK AUSTEN; Fiscal Year: 2012
    ..and the leukocyte immunoglobulin-like receptors (LIRs) with ITIM motifs to attenuate the activation of mouse mast cells and PMNs and human basophils and eosinophils;RNA-binding proteins such as TIA and TIAR, that serve as ..
  20. Galectin-3 in regulation of allergic skin inflammation
    Fu Tong Liu; Fiscal Year: 2013
    ..that atopic dermatitis is attributable to a Th2-mediated inflammatory response and T cells, dendritic cells, and mast cells play important roles...
  21. Molecular Mechanisms of Ion Channels in T Lymphocytes
    Michael D Cahalan; Fiscal Year: 2013
    ..Important cellular functions of Orai1 have been identified in lymphocytes, mast cells, blood platelets, sweat and salivary glands, dentition, vascular smooth muscle, endothelial cells, and skeletal ..
  22. Novel Erythroid Cell Membrane Protein
    Emery H Bresnick; Fiscal Year: 2010
    ..stem cells (HSCs), whereas GATA-1 promotes the differentiation of erythroid, megakaryocyte, eosinophil, and mast cells. Analysis of GATA-1 function in GATA-1-null erythroid precursor cells revealed a novel target gene, mFam55B...
  23. Genetic Mapping Of Novel Molecular Players in Itch
    RACHEL BETH BREM; Fiscal Year: 2013
    ..b>Mast cells release a variety of puritogens that mediate allergy-evoked itch, psoriasis and eczema, and anti-histamines are ..
  24. Role of Surfactant in Innate and Adaptive Immunity
    Jo Rae Wright; Fiscal Year: 2010
    ..antigen uptake, intracellular targeting, and antigen presentation by bone marrow derived dendritic cells and mast cells. Blocking antibodies and receptor null mice will be used to test the hypothesis that dendritic and mast cell ..
  25. FUNCTION OF THE ENTERIC NERVOUS SYSTEM
    JACKIE WOOD; Fiscal Year: 2013
    ..interactive signaling between the enteric nervous system (ENS), spinal sensory afferent innervation and enteric mast cells with guinea pig small intestine as the experimental model...
  26. Oncogenic Kit receptor signaling in vivo
    Peter Besmer; Fiscal Year: 2012
    ..suppression of apoptosis, cell adhesion, chemotaxis and secretory responses in vitro in bone marrow derived mast cells (BMMC)...
  27. Gut mucosal mast cells are activated by fat absorption: physiology and mechanism
    Patrick Tso; Fiscal Year: 2013
    ..We made the novel observation that intestinal mucosal mast cells (MMC) are activated by fat absorption...
  28. Pro-inflammatory role of megakaryocytes in arthritis
    Peter A Nigrovic; Fiscal Year: 2013
    ..types hav been shown to participate in this process, including neutrophils, macrophages, synovial fibroblasts, mast cells, and most recently platelets. Here we present evidence implicating another lineage, the megakaryocyte...
  29. Adipose Tissue Macrophage Iron Metabolism in Obesity
    Alyssa H Hasty; Fiscal Year: 2013
    ..form crown-like structures around dead adipocytes, 2) other leukocytes such as T lymphocytes, B cells, mast cells, and neutrophils are also recruited to AT, and 3) the AT macrophages can be polarized toward an M1 or M2 ..
  30. The role of stress and mast cells in a preclinical mouse model of migraine
    ANN CHRISTINE RADDANT; Fiscal Year: 2013
    ..Instead, a potential mechanism that is supported by new preliminary data is activation of mast cells. Mast cells contain a host of vasoactive and neuroactive substances that are known to be released by ..
  31. Mast cell actions in chronic progressive versus relapsing remitting EAE
    JULIANNE K HATFIELD; Fiscal Year: 2013
    ..It has been clearly demonstrated that mast cells, an innate cell type that is widely distributed throughout the body, negatively modifies disease course...
  32. Role of Vav and Rac in KIT oncogenesis
    Reuben Kapur; Fiscal Year: 2013
    ..is a unique receptor with important functional roles in melanocytes, germ cells, interstitial cells of Cajal, mast cells, and hematopoietic stem cells...
  33. Defining the role of mast cells during influenza A virus infection
    Joshua J Obar; Fiscal Year: 2012
    ..proposal will examine the early host response elements to IAV infection, specifically examining the role that mast cells and protease- activated receptors play in regulating the morbidity and mortality associated with IAV infection...
  34. The Role of IgE in Autoimmune Skin Diseases
    Janet A Fairley; Fiscal Year: 2013
    ..of the IgE either to BP180 on the surface of epidermal keratinocytes or to its high affinity receptor, Fc5RI, on mast cells and potentially eosinophils...
  35. TSLP and Childhood Asthma
    Steven F Ziegler; Fiscal Year: 2012
    ..CD4+ T cells play a triggering role in the activation and/or recruitment of IgE antibody-producing B cells, mast cells and eosinophils, i.e. the cellular triad involved in the allergic inflammation...
  36. Molecular Basis of the Anti-inflammatory Action of MAYP/PSTPIP2
    Violeta Chitu; Fiscal Year: 2012
    ..MAYP is selectively expressed in macrophages, mast cells and osteoclasts and is an actin-bundling protein that regulates filopodia formation and macrophage motililty...
  37. HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMS
    Donata Vercelli; Fiscal Year: 2013
    ..We will examine CD4 Th cells at distinct differentiation stages and, albeit less extensively, mast cells. Specific objectives are to define the role of HS4 (Aim 1) and HS5 (Aim 2), which reside in the distal IL13 ..
  38. Exploiting Protease-Activatable Agents to Characterize and Treat Asthma
    Csilla Felsen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Asthma is an airway disease characterized by inflammation;accumulation of mast cells, eosinophils, and neutrophils;and intermittent, reversible airway obstruction that affects more than 300 million ..
  39. Role of mast cells in obesity
    Guo Ping Shi; Fiscal Year: 2012
    b>Mast cells are essential effector cells in the elicitation of the allergic responses by releasing cytoplasmic granules. Our recent studies suggest that mast cells participate in human pathobiology beyond allergic inflammation...
  40. CGRP-induced light aversion in a preclinical migraine model
    Andrew F Russo; Fiscal Year: 2013
    ..There is evidence that migraine is a neural disorder that can be exacerbated by inflammatory signals: dural mast cells activate trigeminal nociceptive pathways, mast cell degranulation triggers migraine-like headaches, and anti-..
  41. Metabolic Engineering of Chinese Hamster Ovary Cells for Production of Heparin
    Susan T Sharfstein; Fiscal Year: 2011
    ..glycosaminoglycan) found covalently attached to a core protein stored in intracellular granules of mast cells that are found in large numbers in the intestines and lungs of many animals...
  42. The Role of Mast Cells in the Pathophysiology of Intracranial Aneurysm
    Tomoki Hashimoto; Fiscal Year: 2013
    ..We have very exciting animal study data suggesting that while mast cells are not critical for the formation of aneurysms, mast cells play a significant role in te development of ..
  43. Perinatal exposure to environmental estrogens and asthma pathogenesis
    Terumi Midoro Horiuti; Fiscal Year: 2010
    ..Cells of the innate immune system (mast cells, basophils and eosinophils) contribute directly to the allergic inflammation and can promote the differentiation ..
  44. STRUCTURE-FUNCTION RELATIONSHIPS OF IMMUNORECEPTORS
    Barbara A Baird; Fiscal Year: 2013
    ..Focus is primarily on the high affinity receptor for IgE, Fc5RI, on mast cells, which plays a central role in the allergic immune response and serves as a valuable model system for these ..
  45. Analyses of neutrophil interaction with immune complexes
    Tanya N Mayadas; Fiscal Year: 2013
    ..ICs, while 2) Fc[unreadable]RIIA mediated recruitment and associated injury is regulated by cytokines, resident mast cells and macrophages, and requires its ITAM motif...
  46. The alpha 2 beta 1 Integrin: Innate Immunity to Pathogens &Tumors
    Mary M Zutter; Fiscal Year: 2013
    ..Inflammation, mast cells, T cells and immune complexes are required for tumor progression in the transgenic mouse model of epithelial ..
  47. The role of SP-A in Mp-induced exacerbations during allergic airway disease.
    JULIE GUNNELLS LEDFORD; Fiscal Year: 2013
    ..It is not currently known if Mp interacts with pulmonary mast cells and causes activation/degranulation and if SP-A plays a role in protecting from Mp-stimulation, thereby ..
  48. NEUROFIBROMATOSIS TYPE 1 GENE REGULATES MYELOPOIESIS
    DAVID W CLAPP; Fiscal Year: 2012
    ..tumors composed of Schwann cells, endothelial cells, fibroblasts, and high concentrations of degranulating mast cells. Studies in cutaneous, mammary, and pancreatic cancers have emphasized the role of inflammatory cells, including ..
  49. ROLE OF TNF IN BLADDER INFLAMMATION
    David J Klumpp; Fiscal Year: 2010
    ..that patient symptoms are correlated with lesions of the urothelium that lines the bladder and accumulation of mast cells in the underlying lamina propria...
  50. Antigen Binding, Crosslinking and Transmembrane Signaling
    David A Holowka; Fiscal Year: 2013
    ..will continue our long-term efforts to understand molecular mechanisms by which crosslinking of IgE receptors on mast cells triggers complex cellular signaling processes that lead to important functional responses in immune host defense...
  51. Mast cell dependent inflammatory cascade during influenza A virus infection
    Joshua J Obar; Fiscal Year: 2013
    ..include alveolar epithelial cells, endothelial cells, tissue resident alveolar macrophages, dendritic cells, and mast cells. However, the role of the mast cell has been under explored during respiratory viral infection...
  52. Role of IL-4R-alpha signaling in food allergen sensitization and anaphylaxis
    Hans C Oettgen; Fiscal Year: 2012
    ..The F709 system provides a powerful resource both for focused analysis of direct IL-4 effects on mast cells T cells and intestinal epithelium and for probing the interactions between mast cells, IgE antibodies, TH2 and ..
  53. Development of Assays for Inhibitors of LysRS in Mast Cell Activation
    Min Guo; Fiscal Year: 2013
    ..Antigen induction of mast cells triggers the phosphorylation of LysRS on Ser207...
  54. The Role of ASICs in Migraine Pathophysiology
    Gregory O Dussor; Fiscal Year: 2013
    ..e. the dura mater) are sensitive to substances released from mast cells. Mast cells can be activated following stress and increased estrogen levels, both of which are associated with ..
  55. Regulation of store-operated Ca2+ entry: STIM and ORAI
    Anjana Rao; Fiscal Year: 2013
    ..proteins mediate store- operated Ca2+ entry not only in immune/ haematopoietic cells (T and B lymphocytes, mast cells, platelets) but also in skeletal muscle and potentially many other cell types...
  56. Modulation of calcium signaling by changes in STIM expression
    Jonathan Soboloff; Fiscal Year: 2013
    ..in EGR1 and EGR4 expression to change STIM1 and STIM2 expression will be examined in both fibroblasts and mast cells derived from wild type and EGR1 knockout mice, using insulin, Platelet-Derived Growth Factor (PDGF;fibroblasts) ..
  57. Use of Substance P antagonists to regulate the skin immune function
    Adriana T Larregina; Fiscal Year: 2013
    ..In the skin, SP is mainly secreted by sensory C-fibers that interconnect cells with immune function such as LCs, mast cells (MCs), and keratinocytes. SP exerts its immunostimulatory functions by binding the neurokinin 1 receptor (NK1R)...
  58. The Roles of Tumor Microenvironment in Neurofibroma Development and Therapeutics
    Lu Le; Fiscal Year: 2013
    ..cells, nerves, endothelial cells, fibroblasts and additionally a large number of infiltrating inflammatory mast cells. However, little is known about the molecular mechanisms mediating the initiation and progression of these ..
  59. The effects of stress on the pathophysiology of endometriosis
    MARIELLY CUEVAS; Fiscal Year: 2010
    ..determine whether prior stress increases the likelihood of developing endometriosis;and 4) determine the role of mast cells in the development of endometriosis during stress...
  60. Molecular Mechanisms of IL-4 and IL-13 Signaling
    Achsah D Keegan; Fiscal Year: 2010
    ..IL-4 and IL-13 are produced by Type 2 (TH2) helper T cells in response to antigen receptor engagement, by mast cells and basophils upon cross-linkage of the high affinity receptor for immunoglobulin E (IgE), and by activated ..
  61. Regulation of Myeloid Development and Function by II-4
    Achsah D Keegan; Fiscal Year: 2010
    The cytokine IL-4 is produced by TH2 lymphocytes, NKT cells, and by cells of the innate immune system including mast cells, and eosinophils...
  62. Regulation and Function of Immunoglobulin D in Mucosal Immune Defense
    Andrea Cerutti; Fiscal Year: 2013
    ..and contributes to mucosal immunity by activating local and systemic innate immune cells such as basophils and mast cells through interaction with heparin, eosinophil cationic protein and inflammasomes. Three aims are proposed...
  63. MAST CELL MEMBRANE GLYCOLIPID EXPRESSION AND FUNCTION
    Michael Raizman; Fiscal Year: 1991
    ..studies of the expression and function of a cholera toxin-binding glycosphingolipid, ganglisoside GM1, on mouse mast cells at different stages of development...
  64. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    b>Mast cells are known for their involvement in allergic reactions where they secrete many vasoactive and proinflammatory molecules. Mast cells are located perivascularly close to nerve endings and are activated by nerve stimulation...
  65. GROWTH AND DIFFERENTIATION OF HUMAN MAST CELLS
    ROBERT BRESSLER; Fiscal Year: 1993
    Research of human mast cells has been constrained by the lack of human mast cell lines and the inability to grow human mast cells in vitro...
  66. GAMMA GLOBULIN STRUCTURE AND HYPERSENSITIVITY
    Kimishige Ishizaka; Fiscal Year: 1992
    Adapted from applicant's abstract): It has been established that IgE molecules bind to Fc delta receptors on mast cells with high affinity, and that cross linking of the cell bound IgE antibodies by antigen trigger the cells for the ..
  67. MAST CELL MATRIX METALLOPROTEINASES IN LUNG INJURY
    Kenneth Fang; Fiscal Year: 2000
    ..Certain fibrotic lung diseases demonstrate a high density of mast cells, implicating them in the complex mechanisms of tissue remodeling, an area of investigation focusing on a growing ..
  68. BIOCHEMISTRY OF MAST CELL SECRETORY GRANULE ENZYMES
    Lawrence Schwartz; Fiscal Year: 1999
    b>Mast cells play a central role in the pathogenesis of the allergic response and neutral proteases are the major protein components on a weight basis of the secretory granules of human mast cells...
  69. IN VITRO STUDIES OF THE MECHANISM OF ANAPHYLAXIS
    FRANK AUSTEN; Fiscal Year: 1999
    The proposed investigations on the cells, mast cells and eosinophils, and the mediators, preformed secretory granule constituents and newly derived membrane lipid metabolites, of immediate hypersensitivity reactions continue a long term ..
  70. Mast-Cell Renin and Local ANG II Formation
    RANDI BETH SILVER; Fiscal Year: 2010
    ..Based on recent evidence reported from our lab that mast cells express and release active renin, we hypothesize that renin released from mast cells infiltrating the kidney ..
  71. MAST CELLS IN PULMONARY INFLAMMATION
    SOMAN ABRAHAM; Fiscal Year: 1999
    ..b>Mast cells, which are known primarily for their role in IgE- mediated allergic reactions, are suited to initiate and ..
  72. SECRETION OF BLADDER MAST CELL MEDIATORS IN IC
    Theoharis Theoharides; Fiscal Year: 1991
    b>Mast cells have been traditionally found at the interfaces with the body's exterior, such as the skin and the lungs...
  73. Mast Cells and the Host Response in the Lung
    Paul Wolters; Fiscal Year: 2007
    The long-term objective of our research is to determine the mechanisms by which mast cells regulate the host response to bacterial lung infections and to be able to modify how mast cells coordinate this response in ways that benefit the ..
  74. ROLE OF NERVOUS SYSTEM MAST CELLS IN DEMYELINATION
    David Johnson; Fiscal Year: 1990
    ..are attracted to the myelin, or how they cross the blood- brain barrier (in MS) or blood-nerve barrier in GBS)- Mast cells are situated in strategic perivascular locations in both the peripheral (PNS) and central (CNS) nervous systems...
  75. Adapter molecules on C3a receptor signaling in mast cells
    Hydar Ali; Fiscal Year: 2009
    It is well documented that aggregation of high affinity IgE receptors (FceRI) on mast cells mediates allergic and hypersensitivity diseases. Not surprisingly, this receptor has been the subject of intense research investigation...