Genomes and Genes
Summary: A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
Publications374 found, 100 shown here
- Osteoclast differentiation and activationWilliam J Boyle
Protein Pathways, Inc, Woodland Hills, California 91367, USA
Nature 423:337-42. 2003b>Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone matrix, then secrete acid and lytic enzymes that degrade it in a specialized, extracellular compartment...
- Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationD L Lacey
Department of Pathology, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
Cell 93:165-76. 1998..OPGL directly activates isolated mature osteoclasts in vitro, and short-term administration into normal adult mice results in osteoclast activation associated with ..
- Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclastsHiroshi Takayanagi
Department of Immunology, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Japan
Dev Cell 3:889-901. 2002Signaling by RANKL is essential for terminal differentiation of monocytes/macrophages into osteoclasts. The TRAF6 and c-Fos signaling pathways both play important roles downstream of RANKL...
- The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formationKazuhisa Nakashima
Department of Molecular Genetics and Program in Genes and Development, M D Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Cell 108:17-29. 2002..In endochondral skeletal elements of Osx null mice, mesenchymal cells, together with osteoclasts and blood vessels, invade the mineralized cartilage matrix...
- Osteoprotegerin: a novel secreted protein involved in the regulation of bone densityW S Simonet
Department of Molecular Genetics, Amgen Inc, Thousand Oaks, California 91320, USA
Cell 89:309-19. 1997..These data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity...
- Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLH Yasuda
Research Institute of Life Science, Snow Brand Milk Products Co, Ltd, 519 Ishibashi machi, Shimotsuga gun, Tochigi 329 0512, Japan
Proc Natl Acad Sci U S A 95:3597-602. 1998b>Osteoclasts, the multinucleated cells that resorb bone, develop from hematopoietic cells of monocyte/macrophage lineage...
- Evidence for osteocyte regulation of bone homeostasis through RANKL expressionTomoki Nakashima
Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo, Japan
Nat Med 17:1231-4. 2011..been postulated to orchestrate bone homeostasis by regulating both bone-forming osteoblasts and bone-resorbing osteoclasts. We find here that purified osteocytes express a much higher amount of receptor activator of nuclear factor-κB ..
- Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiationDonald A Glass
Department of Molecular and Human Genetics, Bone Disease Program of Texas, Houston, 77030, USA
Dev Cell 8:751-64. 2005....
- IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesisS Kotake
The Institute of Rheumatology, Tokyo Women s Medical University, Tokyo 162 0054, Japan
J Clin Invest 103:1345-52. 1999..with recombinant human IL-17 induced the formation of multinucleated cells, which satisfied major criteria of osteoclasts, including tartrate-resistant acid phosphatase activity, calcitonin receptors, and pit formation on dentine ..
- Matrix-embedded cells control osteoclast formationJinhu Xiong
Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences UAMS, Little Rock, Arkansas, USA
Nat Med 17:1235-41. 2011b>Osteoclasts resorb the mineralized matrices formed by chondrocytes or osteoblasts...
- Mechanisms of bone metastasisG David Roodman
Department of Medicine, Division of Hematology Oncology, University of Pittsburgh, School of Medicine Hematology, The University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
N Engl J Med 350:1655-64. 2004
- The molecular understanding of osteoclast differentiationMasataka Asagiri
Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Yushima 1 5 45, Tokyo 113 8549, Japan
Bone 40:251-64. 2007b>Osteoclasts are multinucleated cells of monocyte/macrophage origin that degrade bone matrix...
- Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligandH Hsu
Department of Cell Biology, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
Proc Natl Acad Sci U S A 96:3540-5. 1999..The RANK mRNA was highly expressed by isolated bone marrow-derived osteoclast progenitors and by mature osteoclasts in vivo...
- Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand familiesT Suda
Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
Endocr Rev 20:345-57. 1999..RANKL is also involved in the survival and fusion of pOCs and activation of mature osteoclasts. OPG, which has also been called OCIF or TR1, is a soluble receptor for RANKL and acts as a decoy receptor in ..
- RANKL-RANK signaling in osteoclastogenesis and bone diseaseTeiji Wada
Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohrgasse 3, A 1030 Vienna, Austria
Trends Mol Med 12:17-25. 2006..Designing novel drugs that target RANKL-RANK and their signaling pathways in osteoclasts could potentially revolutionize the treatment of many diseases associated with bone loss such as arthritis, ..
- Therapeutic approaches to bone diseasesG A Rodan
Merck Research Laboratories, West Point, PA 19486, USA St Vincent s Institute of Medical Research, Melbourne 3065, Australia
Science 289:1508-14. 2000The strength and integrity of our bones depends on maintaining a delicate balance between bone resorption by osteoclasts and bone formation by osteoblasts...
- OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisY Y Kong
Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
Nature 397:315-23. 1999..Mice with a disrupted opgl gene show severe osteopetrosis and a defect in tooth eruption, and completely lack osteoclasts as a result of an inability of osteoblasts to support osteoclastogenesis...
- The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptorB R Wong
Laboratory of Immunology, The Rockefeller University, New York, New York 10021, USA
J Biol Chem 273:28355-9. 1998..T-cells, bone marrow stromal cells, and osteoblasts, regulates the function of dendritic cells (DC) and osteoclasts. The TRANCE receptor (TRANCE-R), recently identified as receptor activator of NF-kappabeta (RANK), activates NF-..
- Transforming growth factor-beta1 to the boneKatrien Janssens
Department of Medical Genetics, University of Antwerp, Campus Drie Eiken, 2610 Antwerp, Belgium
Endocr Rev 26:743-74. 2005..This review provides an overall picture of the bone-specific actions of TGF-beta1 and reconciles experimental discrepancies that have been reported for this multifunctional cytokine...
- c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodelingA E Grigoriadis
Research Institute of Molecular Pathology IMP, Vienna, Austria
Science 266:443-8. 1994..Fos mutant mice were found to have a block in the differentiation of bone-resorbing osteoclasts that was intrinsic to hematopoietic cells...
- Essential role of beta-catenin in postnatal bone acquisitionSheri L Holmen
Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
J Biol Chem 280:21162-8. 2005..Loss of beta-catenin produced severe osteopenia with striking increases in osteoclasts, whereas constitutive activation of beta-catenin in the conditional Apc mutants resulted in dramatically ..
- Receptor activator of nuclear factor κB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone lossMelda Onal
Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
J Biol Chem 287:29851-60. 2012..These results demonstrate that lymphocyte RANKL is not involved in basal bone remodeling, but B cell RANKL does contribute to the increase in osteoclasts and cancellous bone loss that occurs after loss of estrogen.
- Role of NF-κB in the skeletonDeborah Veis Novack
Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
Cell Res 21:169-82. 2011..NF-κB controls the differentiation or activity of the major skeletal cell types - osteoclasts, osteoblasts, osteocytes and chondrocytes...
- Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systemsHiroshi Takayanagi
Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8549, Japan
Nat Rev Immunol 7:292-304. 2007..Although osteoimmunology started with the study of the immune regulation of osteoclasts, its scope has been extended to encompass a wide range of molecular and cellular interactions, including those ..
- Osteoprotegerin is a receptor for the cytotoxic ligand TRAILJ G Emery
Department of Molecular Biology, King of Prussia, Pennsylvania 19406, USA
J Biol Chem 273:14363-7. 1998..OPG inhibits TRAIL-induced apoptosis of Jurkat cells. Conversely, TRAIL blocks the anti-osteoclastogenic activity of OPG. These data suggest potential cross-regulatory mechanisms by OPG and TRAIL...
- Autoamplification of NFATc1 expression determines its essential role in bone homeostasisMasataka Asagiri
Department of Cell Signaling, Tokyo Medical and Dental University, Japan
J Exp Med 202:1261-9. 2005..redundant in the immune system, but it was suggested that NFATc1 is required exclusively for differentiation of osteoclasts in the skeletal system...
- Functions of RANKL/RANK/OPG in bone modeling and remodelingBrendan F Boyce
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA
Arch Biochem Biophys 473:139-46. 2008..Thus, the relative concentration of RANKL and OPG in bone is a major determinant of bone mass and strength. Here, we review our current understanding of the role of the RANKL/RANK/OPG system in bone modeling and remodeling...
- RANK is essential for osteoclast and lymph node developmentW C Dougall
Immunex Corporation, Seattle, Washington 98101 USA
Genes Dev 13:2412-24. 1999..myeloid precursors but provided a necessary and specific signal for the differentiation of myeloid-derived osteoclasts. RANK(-/-) mice also exhibited a marked deficiency of B cells in the spleen...
- An overview of the regulation of bone remodelling at the cellular levelJasreen Kular
School of Pathology and Laboratory Medicine, The University of Western Australia, Western Australia, Australia
Clin Biochem 45:863-73. 2012..To review the current literature on the regulation of bone remodelling at the cellular level...
- Stimulation of bone formation in vitro and in rodents by statinsG Mundy
OsteoScreen, 2040 Babcock Road, San Antonio, TX 78229, USA
Science 286:1946-9. 1999..Thus, in appropriate doses, statins may have therapeutic applications for the treatment of osteoporosis...
- Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasisTakako Koga
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
Nature 428:758-63. 2004..Receptor activator of NF-kappaB ligand (RANKL) regulates the differentiation of bone-resorbing cells, osteoclasts, in the presence of macrophage-colony stimulating factor (M-CSF)...
- Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitroH Yasuda
Research Institute of Life Science, Snow Brand Milk Products Co, Ltd, Tochigi, Japan
Endocrinology 139:1329-37. 1998The morphogenesis and remodeling of bone depends on the integrated activity of osteoblasts that form bone and osteoclasts that resorb bone...
- A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiationNa Kyung Lee
Division of Molecular Life Sciences and Center for Cell Signaling Research, Ewha Womans University, Seoul, 120 750, Korea
Blood 106:852-9. 2005..ligand (RANKL) is essential for differentiation of bone marrow monocyte-macrophage lineage (BMM) cells into osteoclasts. Here, we show RANKL stimulation of BMM cells transiently increased the intracellular level of reactive oxygen ..
- Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitroEdith Bonnelye
Laboratoire de Génomique Fonctionelle de Lyon, Université de Lyon UMR5242, CNRS INRA ENS Université Lyon1 IFR 128 Biosciences Lyon Gerland, 46, Allee d Italie, 69007 Lyon, France
Bone 42:129-38. 2008..the dual mode of action of strontium ranelate in bone was tested in vitro, on primary murine osteoblasts and osteoclasts derived from calvaria and spleen cells, respectively...
- The architecture of the adhesive apparatus of cultured osteoclasts: from podosome formation to sealing zone assemblyChen Luxenburg
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
PLoS ONE 2:e179. 2007b>Osteoclasts are bone-degrading cells, which play a central role in physiological bone remodeling. Unbalanced osteoclast activity is largely responsible for pathological conditions such as osteoporosis...
- Cellular and molecular mechanisms of bone remodelingLiza J Raggatt
Faculty of Health Sciences, The University of Queensland Centre for Clinical Research, Royal Brisbane Hospital, Herston 4029, Australia
J Biol Chem 285:25103-8. 2010..In addition to the traditional bone cells (osteoclasts, osteoblasts, and osteocytes) that are necessary for bone remodeling, several immune cells have also been ..
- Normal bone anatomy and physiologyBart Clarke
Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, W18 A, 200 1st Street SW, Rochester, MN 55905, USA
Clin J Am Soc Nephrol 3:S131-9. 2008..This information lays the groundwork for understanding the utility and clinical applications of iliac crest bone biopsy...
- Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblastXiao Chun Bai
Department of Cell Biology, Southern Medical University, Guangzhou 510515, China
J Biol Chem 280:17497-506. 2005..These results demonstrate that ROS stimulates RANKL expression via ERKs and PKA-CREB pathway in mouse osteoblasts and via ERKs and HSF2 in human MG63 cells...
- Filamin A regulates monocyte migration through Rho small GTPases during osteoclastogenesisRoland Leung
CIHR Group in Matrix Dynamics, University of Toronto, Toronto, Ontario, Canada
J Bone Miner Res 25:1077-91. 2010..the tibiae and femora of wild type (WT) and Flna-null mice were cultured for 6 days with M-CSF and RANKL, and osteoclasts were identified by tartrate-resistant acid phosphatase (TRACP) staining...
- Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralizationMei Zhang
Department of Medicine, University of Cincinnati, Ohio 45267, USA
J Biol Chem 277:44005-12. 2002..This action is likely to be particularly important during the pubertal growth spurt when rapid bone formation and consolidation are required...
- Osteopetrosis in mice lacking haematopoietic transcription factor PU.1M M Tondravi
Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Nature 386:81-4. 1997b>Osteoclasts are multinucleated cells and the principal resorptive cells of bone. Although osteoclasts are of myeloid origin, the role of haematopoietic transcription factors in osteoclastogenesis has not been explored...
- Bone damage in rheumatoid arthritis: mechanistic insights and approaches to preventionSougata Karmakar
Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, UMass Memorial Medical Center, Lazare Research Building, Suite 223, 364 Plantation Street, Worcester, MA 01605, USA
Rheum Dis Clin North Am 36:385-404. 2010..In this review, the authors discuss the current understanding of pathogenic mechanisms of bone erosion in RA and examine current therapeutic approaches to prevent this damage...
- The osteoclast and its unique cytoskeletonSteven L Teitelbaum
Departments of Pathology and Immunology, and Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Ann N Y Acad Sci 1240:14-7. 2011..Absence of any component of this signaling pathway compromises osteoclast cytoskeletal organization and abridges bone resorption...
- Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritisChristopher T Ritchlin
Allergy, Immunology and Rheumatology Unit, University of Rochester Medical Center, Rochester, New York 14642, USA
J Clin Invest 111:821-31. 2003..Moreover, PsA PBMCs readily formed osteoclasts in vitro without exogenous receptor activator of NF-kappaB ligand (RANKL) or MCSF...
- Regulatory mechanisms of osteoblast and osteoclast differentiationT Katagiri
Department of Biochemistry, School of Dentistry, Showa University, Japan
Oral Dis 8:147-59. 2002..Osteoblasts and osteoclasts are specialized cells responsible for bone formation and resorption, respectively...
- Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cellsAgamemnon E Grigoriadis
Department of Craniofacial Development and Orthodontics, Guy s Hospital, King s College London, London, UK
Blood 115:2769-76. 2010..Here, we report the stepwise generation of bone-resorbing osteoclasts from human embryonic and induced pluripotent stem cells...
- v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formationSeoung Hoon Lee
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Nat Med 12:1403-9. 2006Matrix-producing osteoblasts and bone-resorbing osteoclasts maintain bone homeostasis. Osteoclasts are multinucleated, giant cells of hematopoietic origin formed by the fusion of mononuclear pre-osteoclasts derived from myeloid cells...
- Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosisS C Manolagas
Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock 72205, USA
Endocr Rev 21:115-37. 2000The adult skeleton regenerates by temporary cellular structures that comprise teams of juxtaposed osteoclasts and osteoblasts and replace periodically old bone with new...
- Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL)M Matsumoto
Laboratories of Cellular Biochemistry and Antibiotics, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama, 351 0198 Japan
J Biol Chem 275:31155-61. 2000..These results indicate that activation of the p38 MAP kinase pathway plays an important role in RANKL-induced osteoclast differentiation of precursor bone marrow cells...
- Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseasesLorenz C Hofbauer
Department of Gastroenterology, Philipps University, Marburg, Germany
JAMA 292:490-5. 2004Bone resorption by osteoclasts is coupled with bone formation by osteoblasts, and this balanced process continuously remodels and adapts the skeleton...
- Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacyR G G Russell
Nuffield Department of Orthopaedic Surgery, Oxford University Institute of Musculoskeletal Sciences The Botnar Research Centre, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK
Osteoporos Int 19:733-59. 2008..There is new knowledge about how they work. The differences that exist among individual BPs in terms of mineral binding and biochemical actions may explain differences in their clinical behavior and effectiveness...
- Bone remodeling during fracture repair: The cellular pictureAaron Schindeler
Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Sydney, Australia
Semin Cell Dev Biol 19:459-66. 2008..In normal bone development, bone remodeling conventionally refers to the removal of calcified bone tissue by osteoclasts. However, in the context of bone repair there are two phases of tissue catabolism: the removal of the initial ..
- Suppression of bone formation by osteoclastic expression of semaphorin 4DTakako Negishi-Koga
Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
Nat Med 17:1473-80. 2011..It is thus becoming increasingly necessary to identify the factors that regulate bone formation. We found that osteoclasts express semaphorin 4D (Sema4D), previously shown to be an axon guidance molecule, which potently inhibits bone ..
- Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1Masahito Matsumoto
Department of Molecular Biology, Saitama Medical School, Saitama, Japan
J Biol Chem 279:45969-79. 2004..RANKL-induced NFATc1 forms a complex with PU.1 in nuclei of osteoclasts following the nuclear accumulation of NFATc1 phosphorylated by the activated p38 MAP kinase...
- IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activationYuhao Gao
Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
J Clin Invest 117:122-32. 2007..Inhibition of IFN-gamma signaling may thus represent a novel strategy to simultaneously reduce inflammation and bone loss in common forms of osteoporosis...
- Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-FosKoichi Matsuo
Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo 160 8582, Japan
J Biol Chem 279:26475-80. 2004b>Osteoclasts are specialized macrophages that resorb bone. Mice lacking the AP-1 component c-Fos are osteopetrotic because of a lack of osteoclast differentiation and show an increased number of macrophages...
- Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cellsSuwen Wei
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Leukoc Biol 88:495-505. 2010..CSF-1R tyrosine phosphorylation, and signaling and synergized with other cytokines to generate macrophages and osteoclasts from cultured progenitors...
- Podosome and sealing zone: specificity of the osteoclast modelPierre Jurdic
Laboratoire de Biologie Moléculaire et Cellulaire UMR 5161 CNRS ENS, IFR 128 BioSciences, Ecole Normale Superieure de Lyon, 46 allee d Italie, F 69007 Lyon, France
Eur J Cell Biol 85:195-202. 2006The bone resorption function of osteoclasts is dependent on the integrity of the actin cytoskeleton...
- DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cellsMitsuru Yagi
Department of Cell Differentiation, The Sakaguchi Laboratory, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
J Exp Med 202:345-51. 2005b>Osteoclasts are bone-resorbing cells that play a pivotal role in bone remodeling. Osteoclasts form large multinuclear giant cells by fusion of mononuclear osteoclasts. How cell fusion is mediated, however, is unclear...
- Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogsLilian I Plotkin
Division of Endocrinology and Metabolism, the Center for Osteoporosis and Metabolic Bone Diseases, The Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, 4301 West Markham, Mail Slot 587, Little Rock, AR 72205, USA
Bone 39:443-52. 2006..On the other hand, only 10 analogs induced apoptosis of RAW-264.7-cell-derived osteoclasts. Each of the 6 bisphosphonates that lack pro-apoptotic activity in osteoclasts but retain anti-apoptotic ..
- CD8+ T cells regulate bone tumor burden independent of osteoclast resorptionKaihua Zhang
Department of Orthopedics, Washington University School of Medicine, St Louis, MO 63110, USA
Cancer Res 71:4799-808. 2011..Our findings show the important contribution of CD8(+) T cells in the regulation of bone metastases regardless of OC status, thus including T cells as critical regulators of tumor growth in bone...
- Mangiferin attenuates osteoclastogenesis, bone resorption, and RANKL-induced activation of NF-κB and ERKEstabelle Ang
School of Surgery, The University of Western Australia, Nedlands, Western Australia 6009, Australia
J Cell Biochem 112:89-97. 2011..drives the activation of downstream signaling pathways; which ultimately induce the formation and activation of osteoclasts. In this study, we showed that a natural immunomodulator, mangiferin, inhibits osteoclast formation and bone ..
- Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulationStefanie Weinert
Leibniz Institut fur Molekulare Pharmakologie FMP, 13125 Berlin, Germany
Science 328:1401-3. 2010..This conductance was even deleterious in Clcn7(+/unc) mice. Clcn7(-/-) and Clcn7(unc/unc) mice accumulated less Cl- in lysosomes than did wild-type mice. Thus, lowered lysosomal chloride may underlie their common phenotypes...
- Osteoclast nuclei of myeloma patients show chromosome translocations specific for the myeloma cell clone: a new type of cancer-host partnership?T L Andersen
Department of Clinical Cell Biology KCB, Southern Denmark University, CeSFUVA, Vejle Hospital, 7100 Vejle, Denmark
J Pathol 211:10-7. 2007..It is widely accepted that this destruction is not caused by the malignant cells themselves, but by osteoclasts, multinucleated cells of monocytic origin that are considered to be the only cells able to degrade bone...
- M-CSF potently augments RANKL-induced resorption activation in mature human osteoclastsJason M Hodge
The Department of Clinical and Biomedical Sciences, Barwon Health, The University of Melbourne, Geelong, Victoria, Australia
PLoS ONE 6:e21462. 2011..Our results reveal a previously unidentified role of M-CSF as a potent stimulator of mature OC resorbing activity, possibly mediated via ERK upstream of c-fos...
- New insights into osteoclastogenic signaling mechanismsTomoki Nakashima
Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8549, Japan
Trends Endocrinol Metab 23:582-90. 2012..This process is the fundamental basis for the maintenance of normal bone mass and architecture. Osteoclasts play a crucial role in both physiological and pathological bone resorption, and receptor activator of nuclear ..
- RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritisPing Li
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA
J Bone Miner Res 19:207-13. 2004..RANK signaling is not required for the TNFalpha-stimulated increase in CD11b(hi) osteoclast precursors but is essential for mature osteoclast formation...
- RGS10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulationShuying Yang
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts 02115, USA
Genes Dev 21:1803-16. 2007..signaling proteins and found regulator of G-protein signaling 10 (RGS10) is predominantly expressed in osteoclasts. We generated RGS10-deficient (RGS10-/-) mice that exhibited severe osteopetrosis and impaired osteoclast ..
- IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiologySteeve Kwan Tat
Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Faculte de Medecine, 1 rue Gaston Veil, BP 53508, 44035 Nantes 1, France
Cytokine Growth Factor Rev 15:49-60. 2004All osteogenic cells (osteoclasts, osteoblasts) contribute individually to bone remodeling. Their cellular interactions control their cellular activities and the bone remodeling intensity...
- Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axisNacksung Kim
Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, Korea
J Exp Med 202:589-95. 2005b>Osteoclasts are derived from myeloid lineage cells, and their differentiation is supported by various osteotropic factors, including the tumor necrosis factor (TNF) family member TNF-related activation-induced cytokine (TRANCE)...
- IL-1 mediates TNF-induced osteoclastogenesisShi Wei
Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Invest 115:282-90. 2005..Thus, IL-1 mediates the osteoclastogenic effect of TNF by enhancing stromal cell expression of RANKL and directly stimulating differentiation of osteoclast precursors...
- Osteoimmunology and the effects of the immune system on boneHiroshi Takayanagi
Department of Cell Signaling, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan
Nat Rev Rheumatol 5:667-76. 2009..The interaction between T cells and osteoclasts is a critical issue in the field of osteoimmunology...
- Localization of RANKL (receptor activator of NF kappa B ligand) mRNA and protein in skeletal and extraskeletal tissuesV Kartsogiannis
Department of Medicine, The University of Melbourne and St Vincent s Institute of Medical Research, St Vincent s Hospital, Fitzroy, Victoria, Australia
Bone 25:525-34. 1999..Expression of RANKL mRNA and protein in osteoclasts was variable with those within resorption lacunae showing the strongest signal/staining...
- Osteoclast-osteoblast communicationKoichi Matsuo
Department of Microbiology and Immunology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, 160 8582 Tokyo, Japan
Arch Biochem Biophys 473:201-9. 2008..c-Fms, RANK and costimulatory molecules, such as osteoclast-associated receptor (OSCAR), and differentiate into osteoclasts following cell-cell contact with osteoblasts, which express ligands...
- Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulatorNorihiro Ishida
Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630 0101, Japan
J Biol Chem 277:41147-56. 2002..identified as genes whose enhanced expressions were fairly correlated with an efficient induction of matured osteoclasts. Moreover, cyclosporin A significantly suppressed the multinucleated cell formation accompanying the reduction ..
- B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal diseaseToshihisa Kawai
Department of Immunology, The Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA
Am J Pathol 169:987-98. 2006..These results suggest that activated T and B cells can be the cellular source of RANKL for bone resorption in periodontal diseased gingival tissue...
- Denosumab and bisphosphonates: different mechanisms of action and effectsRoland Baron
Department of Medicine, Harvard Medical School, Endocrine Unit, Massachusetts General Hospital, Boston, MA 02115, USA
Bone 48:677-92. 2011..and/or focal osteolysis as in rheumatoid arthritis or periodontal disease, most approaches target the osteoclasts, the cells that resorb bone. Bisphosphonates are currently the most widely used antiresorptive therapies...
- Cellular mechanisms of bone remodelingErik Fink Eriksen
Department of Clinical Endocrinology, Oslo University Hospital, Aker, Trondheimsveien 235, 0514 Oslo, Norway
Rev Endocr Metab Disord 11:219-27. 2010..The dominant pathway regulating osteoclast recruitment is the RANKL/OPG system, while many different factors (RUNX, Osterix) are involved in osteoblast differentiation. Both pathways are modulated by calcitropic hormones...
- Intercellular calcium signaling occurs between human osteoblasts and osteoclasts and requires activation of osteoclast P2X7 receptorsNiklas R Jørgensen
Osteoporosis Research Clinic, Dept 545, Copenhagen University Hospital Hvidovre, Kettegaard Alle 30, Hvidovre DK 2650, Denmark
J Biol Chem 277:7574-80. 2002Signaling between osteoblasts and osteoclasts is important in bone homeostasis...
- Blockade of the pore-forming P2X7 receptor inhibits formation of multinucleated human osteoclasts in vitroA Gartland
Human Bone Cell Research Group, Department Human Anatomy and Cell Biology, The University of Liverpool, Liverpool, L69 3GE, UK Alison Gartland umassmed edu
Calcif Tissue Int 73:361-9. 2003b>Osteoclasts are large, multinucleated, terminally differentiated cells formed by the fusion of mononuclear hemopoietic precursors...
- Bidirectional ephrinB2-EphB4 signaling controls bone homeostasisChen Zhao
Department of Microbiology and Immunology, School of Medicine, Keio University, Shinjuku ku, Tokyo, 160 8582, Japan
Cell Metab 4:111-21. 2006Bone homeostasis requires a delicate balance between the activities of bone-resorbing osteoclasts and bone-forming osteoblasts...
- Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survivalL Lum
Tri Institutional Cornell Rockefeller University Memorial Sloan Kettering Cancer Center, Training Program, New York, New York 10021, USA
J Biol Chem 274:13613-8. 1999..We propose that the TRANCE ectodomain is released from cells by TACE or a related metalloprotease-disintegrin, and that this release is an important component of the function of TRANCE in bone and immune homeostasis...
- Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strengthM Chellaiah
Renal Division, Department of Medicine, Barnes Jewish Hospital, Washington University, St Louis, Missouri 63110, USA
J Cell Biol 148:665-78. 2000b>Osteoclasts are unique cells that utilize podosomes instead of focal adhesions for matrix attachment and cytoskeletal remodeling during motility...
- Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKLPaul J Kostenuik
Metabolic Disorders Research, Amgen, Thousand Oaks, California 91320, USA
J Bone Miner Res 24:182-95. 2009..These huRANKL mice have potential utility for characterizing the activity of denosumab in a variety of murine bone disease models...
- The ligand for osteoprotegerin (OPGL) directly activates mature osteoclastsT L Burgess
Department of Mammalian Cell Molecular Biology, Amgen Inc, Thousand Oaks, California 91320 1789, USA
J Cell Biol 145:527-38. 1999..Elliott, A. Colombero, G. Elliott, S. Scully, et al. 1998. Cell. 93: 165-176), but their effects on mature osteoclasts are not well understood...
- Regulatory mechanism of NFATc1 in RANKL-induced osteoclast activationInsun Song
National Research Laboratory for Regulation of Bone Metabolism and Disease, Medical Research Center for Gene Regulation, Brain Korea 21, Chonnam National University Medical School, 5 Hak dong, Dong Ku, Gwangju 501 746, Republic of Korea
FEBS Lett 583:2435-40. 2009..attenuates RANKL-induced bone resorption and overexpression of a constitutively active form of NFATc1 in osteoclasts induces formation of actin rings and resorption pits on dentin slices...
- AMP kinase acts as a negative regulator of RANKL in the differentiation of osteoclastsYoung Sun Lee
Asan Institute for Life Sciences, Seoul 138 736, Republic of Korea
Bone 47:926-37. 2010AMP-activated protein kinase (AMPK) has been reported to stimulate differentiation and proliferation of osteoblasts, but the role of AMPK in the physiology of osteoclasts has not been investigated.
- Estrogens maintain bone mass by regulating expression of genes controlling function and life span in mature osteoclastsYuuki Imai
Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan
Ann N Y Acad Sci 1173:E31-9. 2009..in regulation of bone mass and strength by controlling activity of bone-forming osteoblasts and bone-resorbing osteoclasts. Cellular effects of estrogens are mediated predominantly by the action of estrogen receptor alpha (ERalpha)...
- Bone remodeling in post-menopausal osteoporosisU H Lerner
Department of Oral Cell Biology, Umea University, Umea SE 901 87, Sweden
J Dent Res 85:584-95. 2006..mass in the skeleton is dependent on the coordinated activities of bone-forming osteoblasts and bone-resorbing osteoclasts in discrete bone multi-cellular units...
- Macrophage fusion: the making of osteoclasts and giant cellsAGNES VIGNERY
Yale University School of Medicine, New Haven, CT 06510, USA
J Exp Med 202:337-40. 2005..Fusion is required for the formation of multinucleated osteoclasts and giant cells, although the mechanisms that govern these processes are poorly understood...
- P2 receptor expression, signaling and function in osteoclastsJuan P Reyes
Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
Front Biosci (Schol Ed) 3:1101-18. 2011Skeletal development and bone remodeling depend on the coordinated activity of osteoblasts and osteoclasts, which are responsible for bone formation and resorption, respectively...
- Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infectionDallas Jones
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Clin Invest 121:2534-42. 2011....
- Regulation of sealing ring formation by L-plastin and cortactin in osteoclastsTao Ma
Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
J Biol Chem 285:29911-24. 2010..demonstrated a significant increase in cortactin and a corresponding decrease in L-plastin protein levels in osteoclasts subjected to bone resorption for 18 h in the presence of RANKL, M-CSF, and native bone particles...
- Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansionMasahiro Abe
Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, 3 18 15 Kuramoto cho, Tokushima, 770 8503, Japan
Blood 104:2484-91. 2004..by enhancing osteoclastic bone resorption in its vicinity, suggesting a close interaction between MM cells and osteoclasts (OCs)...
- Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) miceHava Gil-Henn
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06511, USA
J Cell Biol 178:1053-64. 2007The protein tyrosine kinase Pyk2 is highly expressed in osteoclasts, where it is primarily localized in podosomes. Deletion of Pyk2 in mice leads to mild osteopetrosis due to impairment in osteoclast function...
- Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligandJ H Han
Department of Medicine/Hematology, University of Texas Health Science Center, San Antonio, TX 78284, USA
Blood 97:3349-53. 2001..Blood. 2001;97:3349-3353)..
- The role of NFAT in osteoclast formationHiroshi Takayanagi
Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Ann N Y Acad Sci 1116:227-37. 2007b>Osteoclasts are cells of monocyte-macrophage origin that degrade bone matrix...
- Expression of Nox4 in osteoclastsSu Yang
Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA
J Cell Biochem 92:238-48. 2004..In this study, we demonstrated that Nox4 is expressed at a higher level in osteoclasts than that in precursor cells...
- Estrogen blocks M-CSF gene expression and osteoclast formation by regulating phosphorylation of Egr-1 and its interaction with Sp-1S Srivastava
Division of Bone and Mineral Diseases, Washington University School of Medicine, and Barnes Jewish Hospital, St Louis, Missouri 63110, USA
J Clin Invest 102:1850-9. 1998..Thus, by downregulating formation of a novel Egr-1/Sp-1 complex in stromal cells, estrogen deficiency results in enhanced levels of free Sp-1 and increased M-CSF gene expression and osteoclast formation...
- Decoy receptor 3 (DcR3) induces osteoclast formation from monocyte/macrophage lineage precursor cellsC R Yang
Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
Cell Death Differ 11:S97-107. 2004..7 macrophages, and bone marrow cells. DcR3-differentiated cells exhibit characteristics unique for osteoclasts, including polynuclear giant morphology, bone resorption, TRAP, CD51/61, and MMP-9 expression...
- NF-kB signaling blockade abolishes implant particle-induced osteoclastogenesisJohn C Clohisy
Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University School of Medicine, One Barnes Jewish Hospital Plaza, Suite 11300, West Pavillion, St Louis, MO 63110, USA
J Orthop Res 22:13-20. 2004..Again, this inhibitor efficiently blocked particle-induced osteoclastogenesis. Thus, we have shown that pharmaceutical and molecular blockade of NF-kB activation inhibits PMMA particle-directed osteoclastogenesis in vitro...
- CELLULAR BASIS OF CRANIOFACIAL BONE DISORDERSPhilip Osdoby; Fiscal Year: 2002..Information is just beginning to emerge that osteoclasts themselves synthesize and release factors that may influence bone remodeling...
- Immune Regulation of Bone HomeostasisMERVYN NEALE WEITZMANN; Fiscal Year: 2012..The bone destruction that drives osteoporosis is mediated by osteoclasts (OCs), bone resorbing cells that form under the influence of the key osteoclastogenic cytokine Receptor- ..
- BONE MATRIX AND BONE RESORPTIONPaul R Odgren; Fiscal Year: 2012..Both ia rats and the human patient have TRAP+, non-resorbing osteoclasts with defective ruffled borders (RB) and defective secretion...
- Sirtuin/FOXO Signaling in the Regulation of Bone MassStavroula Kousteni; Fiscal Year: 2012..They are also expressed in osteoclasts. SIRT1-dependent deacetylation of FOXO1 is required for its anti-apoptotic effects...
- Novel, Rapidly Translatable Technologies for Healing Long Bone Segmental DefectsChristopher H Evans; Fiscal Year: 2010..Runx2, to identify human osteoblasts, and against human tartrate-resistant acid phosphatase, to identify human osteoclasts. Because of our prior experience with the core technologies to be used in this project, the proposal is "shovel ..
- Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of PeriodontitisJUSTIN RODNEY SAVAGE; Fiscal Year: 2013..gingivalis by macrophages. Third, it inhibits P. gingivalis LPS-induced formation of multinucleated osteoclasts from blood monocytes...
- Identification of Proteins Important for Male OsteoporosisHong Wen Deng; Fiscal Year: 2013..cells (BMMSCs) and peripheral blood monocytes (PBMs) are precursors for osteoblasts (bone formation cells) and osteoclasts (bone resorption cells), respectively...
- Runx Proteins and Sex Steroid Signaling in BoneBaruch Frenkel; Fiscal Year: 2009..The anti-resorptive effects of sex steroids are attributable to both direct pro-apoptotic action in osteoclasts and indirect inhibition of bone turnover via poorly understood mechanisms in osteoblasts and other mesenchymal ..
- Inhibition of bone formation by Prx1Mark S Nanes; Fiscal Year: 2013..Understanding this mechanism will allow us to find new medications that stimulate new bone formation and regeneration of tissue in veterans who suffer from arthritis, aging, and menopause associated fractures. ..
- Alcohol-Induced Bone Resorption: The Role of Oxidative StressMartin J J Ronis; Fiscal Year: 2013..In addition, in vivo studies will be conducted to examine the ability of antioxidants to block EtOH-induced bone resorption. ..
- Radiation-Induced Osteoporosis in Women with Cancer: Mechanisms and PreventionTed A Bateman; Fiscal Year: 2013..Increased expression of proinflammatory cytokines in the marrow preceded activation of osteoclasts, which was followed by evidence (indicated by phosphoSmad2) of activated transforming growth factor-beta (TGF[..
- Mechanisms of Bone Loss from Administration of the Second-Generation AntipsychotiKATHERINE JEAN MOTYL; Fiscal Year: 2013..and homeostasis in a manner that results in impaired bone health as well as acts directly on osteoblasts and osteoclasts to disrupt normal skeletal modeling and remodeling...
- In Vivo Function of TRAF6 As a Target of K63-Linked PolyubiquitinationDEAN BALLARD; Fiscal Year: 2010..of NF-?B (RANK) and CD40, TNFR family members involved in the differentiation and effector functions of osteoclasts and B lymphocytes, respectively...
- Osteoclastic Protein-Tyrosine Phosphatase and ResorptionKin Hing William Lau; Fiscal Year: 2013..estrogen receptor (ER) 1 signaling through an upregulation of the c-Src-dependent phosphorylation of ER1 in osteoclasts, which in turn suppresses bone resorption in adult female but not male PTP-oc transgenic mice...
- The Role of Adipocyte-Induced Inflammation in Prostate Tumor ProgressionAIMALIE LYNNETTE HARDAWAY; Fiscal Year: 2012..Ultimately, these studies should lead to identification of novel signaling pathways and molecular mechanisms predisposing prostate cells to metastasize to bone. ..
- Salivary-based Bone-loss Marker Detection Platform for Point-of-Care ScreeningMANAL BESHAY; Fiscal Year: 2012..naturally and continually undergoes turnover with new bone formation by osteoblasts and old bone resorption by osteoclasts at a balanced rate;any imbalance between the two rates results in varying states of abnormal bone turnover such ..
- Hematopoietic Stem Cell Transplantation in Osteogenesis ImperfectaMeenal Mehrotra; Fiscal Year: 2012..e. HSCs produce blood cells and few other cells like mast cells and osteoclasts, while MSCs generate a number of mesenchymal cells including fibroblasts, adipocytes, chondrocytes and ..
- Signal Transduction Mechanism of Osteoclast DifferentiationNandini Ghosh-Choudhury; Fiscal Year: 2013..The bone remodeling occurs by concerted action of bone forming osteoblasts and bone resorbing osteoclasts. These functionally opposing cells communicate via a paracrine cell signaling network...
- Regulation of glucose metabolism by bone resorption and gamma-carboxylationMathieu Ferron; Fiscal Year: 2012..recently that one mechanism by which osteocalcin is decarboxylated and activated is during bone resorption by osteoclasts. This suggested that osteoclast, the bone-resorbing cell, might also play an important role in the control of ..
- Sex Steroids and Runx Signaling in BoneBaruch Frenkel; Fiscal Year: 2013..They will decipher cryptic mechanisms of action of existing SERMs, and support the rationale development of novel ones, based on their influence on Runx proteins. ..
- Estrogens, androgens, aging, and bone loss in malesStavros C Manolagas; Fiscal Year: 2013..that is not capable of stimulating the nuclear- initiated actions of ER1 reproduces the effects of estradiol on osteoclasts and osteoblasts;and is as potent as estradiol in preventing oxidative stress and ovariectomy-induced bone loss, ..
- Role of inflammation and cellular stress in the pathogenesis of type 2 diabetesLiangyou Rui; Fiscal Year: 2013..The outcome is expected to lead to new therapies for hepatic steatosis and type 2 diabetes by targeting the NIK pathways. ..
- Nuclear Events in PTH Action on BoneNicola C Partridge; Fiscal Year: 2013..Moreover, it will define how HDACs contribute to this. In so doing, the data will also provide new perspectives into treatment of disorders of calcium metabolism, cancer-associated bone disease and other bone disorders. ..
- Novel Drug VS-105 for Treatment of OsteoporosisJinshyun Ruth Wu-Wong; Fiscal Year: 2013..hormone, receptor activator of nuclear factor-kB ligand, and also via direct effects on osteoblasts and osteoclasts. Despite encouraging data on VDRM's benefits for treating osteoporosis, VDRMs are not used in osteoporosis ..
- HYPONATREMIA-INDUCED OSTEOPOROSISJoseph G Verbalis; Fiscal Year: 2010....
- Gene-Engineered and Targeted Stem Cell Therapy for MyelomaSelvarangan Ponnazhagan; Fiscal Year: 2013..Further, osteoclasts enhance angiogenesis in concert with MM cells largely through the cooperative actions of osteopontin from ..
- Purinergic Regulation of Bone MetabolismBruce Neil Cronstein; Fiscal Year: 2013..peripheral blood monocytes and therefore determined whether adenosine A1 receptors also regulated formation of osteoclasts, a related form of multinucleated giant cell...
- STRUCTURE OF THE VACUOLAR ATPaseStephan Wilkens; Fiscal Year: 2013..In higher eukaryotes, V-type ATPases are also found in the plasma membrane of polarized cells such as osteoclasts and renal epithelial cells...
- Pharmacology of Risperidone Effects on Bone Remodeling and Energy MetabolismKaren L Houseknecht; Fiscal Year: 2013....
- FUNCTION AND REGULATION OF OSTEONECTIN IN BONEAnne M Delany; Fiscal Year: 2013..Information obtained from these studies could be used to identify novel targets for therapeutic intervention in the treatment of osteoporosis, and may be used to identify individuals at risk for developing osteoporosis. ..
- Role of Gsalpha in Regulating Osteoblast DifferentiationJOY Y WU; Fiscal Year: 2012..TRAP staining for osteoclasts does not reveal dramatic increase in bone resorption, making a failure of bone formation the more likely ..
- Dynamic Mechanisms of Vitamin D-Induced Gene ExpressionJ Wesley Pike; Fiscal Year: 2012..a dynamic tissue which is remodeled throughout life as a result of the biological activities of osteoblasts and osteoclasts. The production and survival of these cells as well as their metabolic activities are all highly regulated by ..
- ATF4 and OsteoclastogenesisGuozhi Xiao; Fiscal Year: 2013DESCRIPTION (provided by applicant): Osteoclasts (OCLs) are the only bone-resorbing cells that are essential for normal skeletal development and bone remodeling throughout life...
- Regulation of Organized Intestinal Lymphoid Tissues by TRANCE/RANKLIfor R Williams; Fiscal Year: 2012..development of lymph nodes, the differentiation of medullary thymic epithelial cells, the differentiation of osteoclasts, and mammary gland lactation, is also present on stromal cells in ILF and PP...
- The role of caspase-2 in osteoblast-osteoclast interactionsDANIELLE ARDEN VICTOR; Fiscal Year: 2013..level of the clinical osteoporosis marker, deoxypyridinoline (DPD), in urine, and increased numbers of osteoclasts, cells responsible for bone resorption...
- Molecular Mechanisms in Bone ResorptionSteven A Lietman; Fiscal Year: 2012..New information about mechanisms of bone resorption may facilitate the development of novel strategies to decrease bone resorption and may lead to new treatments for osteoporosis. ..
- Bc12 regulates osteoclast survivalJunro Yamashita; Fiscal Year: 2010..In such diseases, osteoclast activity typically predominates over osteoblast activity. Hence, suppression of osteoclasts is a therapeutic strategy for the prevention and treatment of degenerative bone diseases...
- Connection of Mineral and Energy Metabolism by the Nuclear Receptor PPAR-gammaYihong Wan; Fiscal Year: 2013..Therefore, this investigation will significantly impact the broader scientific, clinical, and patient community. ..
- Ethanol Regulates Vacuolar ATPase &PEDFChuhan Chung; Fiscal Year: 2013..This occurs in cells such as osteoclasts where genetic mutations in v-ATPase result in severe skeletal abnormalities and death in humans and in mouse ..
- Regulation of IGF-1 and Insulin Signaling by O-GlcNAc GlycosylationLAUREN ELIZABETH BALL; Fiscal Year: 2013..and IRS-2, which are critical to the formation of new bone and maintaining coupling between osteoblasts and osteoclasts. Signaling through the IRS proteins to PI3K/Akt and/or the Grb2/ERK pathways is mediated and modulated by ..
- Osteoclasts from pluripotent stem cells as vectors to modify bone marrow environmHector L Aguila; Fiscal Year: 2010..development of human ES cells to hematopoiesis towards myeloid development, focusing on conditions to generate osteoclasts. These experiments will test the hypothesis that myeloid cells of human origin derived from modified human ES ..
- Effect of MIP-1 delta on Osteoclast Development and Pathological Bone ResorptionScott L Kominsky; Fiscal Year: 2010..arthritis and periodontitis, has been shown to enhance the development of bone-destroying cells called osteoclasts (OCL)...
- Biomaterials (Mf/Zn/F-BCPs) for osteoporosis therapyYu Zhang; Fiscal Year: 2012..Abstract) Osteoporosis, a silent debilitating bone disease, results when the rate of bone resorption (by osteoclasts) is much greater than the rate of bone formation (by osteoblasts) causing bone loss, deterioration of bone ..
- Cathespin K Radioligands for In Vivo ImagingMichael R Kilbourn; Fiscal Year: 2012..forms of known high affinity inhibitors of cathepsin K, a cyteine protease that in highly expressed in osteoclasts and that is responsible for type I collagen degradation and bone resorption...
- PTHrP Modulation of TRPV1 in Pain Associated with Breast Cancer Bone MetastasisAARON DAVID MICKLE; Fiscal Year: 2013..cancer cells secrete high levels of parathyroid hormone-related peptide (PTHrP), which act on osteoblasts and osteoclasts to induce bone lysis/destruction and subsequent release of nutrients and cell signaling molecules that ..
- Connexin 43 in Bone RemodelingRoberto Civitelli; Fiscal Year: 2013..Like remodeling, modeling requires coordination of osteoblasts (Obl), osteocytes (Ocy) and osteoclasts (Ocl)...
- RANKL and Inflammation-associated Bone LossCHARLES A O'BRIEN; Fiscal Year: 2012..b>Osteoclasts are the only cells capable of degrading bone and RANKL is a protein produced by cells that support osteoclast ..
- ERK Signaling in Inflammatory Bone LossFrancis Young In Lee; Fiscal Year: 2013..Overall impact is high in that we expect to unravel novel anti-osteoclastogenic mechanisms and therapeutic promise of rhCRG in the context of inflammatory osteolysis. ..
- ELUCIDATING THE FUNCTION OF MATRIPTASE-ACTIVATED PDGF D IN BONE METASTATIC PROSTAABDO JAMAL NAJY; Fiscal Year: 2012..mediated maturation of PDGF D may activate the tumor cell derived growth factor resulting in the activation of osteoclasts and osteoblasts leading to an aberrant osseous response...
- Pre-osteoclast fusionPaul R Odgren; Fiscal Year: 2013DESCRIPTION (provided by applicant): Bone resorption by osteoclasts (OCs) exceeding formation by osteoblasts (OBs) is a biological problem with a central role in widespread and costly disorders, including osteoporosis, osteo- and ..
- Molecular Basis of the Anti-inflammatory Action of MAYP/PSTPIP2Violeta Chitu; Fiscal Year: 2012..MAYP is selectively expressed in macrophages, mast cells and osteoclasts and is an actin-bundling protein that regulates filopodia formation and macrophage motililty...
- Role of Darc-Chemokine Interaction in the Trafficking of Osteoclast PrecursorsBouchra Edderkaoui; Fiscal Year: 2012..In terms of mechanism by which Darc regulates osteoclasts, our preliminary studies have shown that 1) M-CSF dependent bone marrow cells derived from Darc-knockout (Darc-..
- Actions of Parathyroid Hormone (PTH)/PTH Related-Peptide Receptor in Osteocytes PAOLA DIVIETI PAJEVIC; Fiscal Year: 2013..lacunae deep within the mineralized matrix of bone and communicate with one another and with osteoblasts and osteoclasts via gap junctions located at the ends of long cytoplasmic processes that course through tunnels (cannalicula) ..
- Phosphorylation of PTH1R by TGF-betaRII in Bone RemodelingTao Qiu; Fiscal Year: 2013..This proposal may reveal a previously unrecognized function for T2RII in bone remodeling and a mechanism for PTH to regulate local growth factor at the level of membrane receptor. ..
- The use of patient-specific iPS cells to identify osteoclast defects in CMDI Ping Chen; Fiscal Year: 2011..applicant plans to use patient-specific iPS cells to study craniometaphyseal dysplasia (CMD) with a focus on osteoclasts (OCs), the bone resorbing cells...
- CSF-1 GENE EXPRESSION IN OSTEOCLAST BIOLOGYSHERRY L ABBOUD-WERNER; Fiscal Year: 2013..knockout (cKO) of CSF-1 in osteocytes/late osteoblasts also show increased Nox4, osteocyte defects, reduced osteoclasts and bone formation, predisposing to bone loss and fracture with age...
- MOLECULAR AND CELLULAR MECHANISMS OF OSTEOPOROSISStavros C Manolagas; Fiscal Year: 2013..of reactive oxygen species (ROS) amplification by p66shc or ROS attenuation by FoxOs in osteoblasts and osteoclasts to skeletal homeostasis and its deregulation with aging, the role of ROS in the effects estrogens on ..
- Genetic Determinants of Physiological Responses to Fluoride in BoneEric T Everett; Fiscal Year: 2012..forms and exposures has been repeatedly shown to have actions on bone matrix and on bone cells (osteoblasts and osteoclasts)...
- Coloney Stimulating Factor 1 regulation and role in boneKARL LEONARD INSOGNA; Fiscal Year: 2010..Preliminary results from mCSF1 knock out mice indicate that they have increased bone mass and reduced number of osteoclasts. To identify CSF-1 target genes in osteoclasts, we have used a gene profiling approach and found 7 genes ..
- Evaluating the role of Thrombospondin-1-CD47 mediated nitric oxide signaling in tSarah Amend; Fiscal Year: 2013..Under homeostatic conditions, bone-resorbing osteoclasts are tightly regulated for healthy bone turnover...
- AgRP neurons regulate bone remodeling in agingKARL LEONARD INSOGNA; Fiscal Year: 2013..2008), we also predict that increasing ROS exposure of the melanocortin system during aging is a critical contributor to aging-associated bone loss and the pathogenesis of osteoporosis. ..
- Complement and OsteoporosisFeng Lin; Fiscal Year: 2013..marrow cells from complement receptor-deficient mice had decreased capacity to differentiate into functional osteoclasts. Further, inhibition of complement signaling suppressed human osteoclast differentiation from hematopoietic ..
- Amelioration of Immune Cell-Mediated Periodontal DiseaseToshihisa Kawai; Fiscal Year: 2012..Recent studies demonstrated unequivocally that host immune responses play a key role in activating osteoclasts and promoting bone resorption in periodontal disease...
- DEGRADABLE HYDROGELS FOR ORAL DELIVERY OF CALCITONINJindrich Kopecek; Fiscal Year: 2003..hCT use in osteoporosis therapy are the stimulation of osteoblasts, specific inhibition of bone resorption by osteoclasts, and prevention of fusion of osteoclast precursors...
- DEGRADABLE HYDROGELS FOR ORAL DELIVERY OF CALCITONINJindrich Kopecek; Fiscal Year: 2001..hCT use in osteoporosis therapy are the stimulation of osteoblasts, specific inhibition of bone resorption by osteoclasts, and prevention of fusion of osteoclast precursors...
- RANK-Associated Inhibitor (RAIN) in Osteoclast FormationBryant Darnay; Fiscal Year: 2007..Mice deleted of RANKL, RANK, or TRAF6 lack osteoclasts and develop severe osteopetrosis while mice lacking OPG develop osteoporosis...
- Innate Immune Bacterial Recognition and OsteoclastogenesisCaroline A Genco; Fiscal Year: 2010..In addition, macrophages contribute to bone resorption through their differentiation to osteoclasts (1)...
- Is Mitf the Missing Puzzle Linking NFATc1 to OsteoclastogenesisYi Ling Lin; Fiscal Year: 2010b>Osteoclasts are bone-resorbing cells essential for maintaining bone mass through modeling and remodeling...
- TRAF6 E3 LIGASE FUNCTION IN OSTEOCLASTOGENESISBryant G Darnay; Fiscal Year: 2010..a central role in the maintenance of the bone homeostasis by regulating the differentiation and activation of osteoclasts. The binding of RANKL to its receptor results in the recruitment of TRAF6, which activates the NF-(B, JNK, p38, ..
- ENDOTHELIAL CELLS AND OSTEOCLAST DEVELOPMENTPatricia Collin Osdoby; Fiscal Year: 1999..which is established during bone development and maintained thereafter between vascular endothelial cells and osteoclasts (of hematopoietic origin) enables vascular endothelial cells to potentially influence the development and/or ..
- Functional Analysis of NHA-oc/NHA2 in vivoRICARDO ANIBAL BATTAGLINO; Fiscal Year: 2010DESCRIPTION (provided by applicant): Bone destruction by osteoclasts is essential for normal bone development...
- MICROPHTHALMIA IN OSTEOCLAST DEVELOPMENTKatherine Weilbaecher; Fiscal Year: 2002..b>Osteoclasts play an important role in the pathogenesis of osteoporosis, osteopetrosis, and a variety of pathological ..
- Function of Phospholipase Cgamma2 in RANKL-Induced OsteoclastogenesisYabing Chen; Fiscal Year: 2010..Pathogenic bone resorption modulated by elevation of osteoclasts is a major cause of bone loss in diseases such as osteoporosis, rheumatoid arthritis and osteolytic bone ..
- TAMOXIFEN MODULATES OSTEOCLAST CA++/CALMODULIN SIGNALINGJay McDonald; Fiscal Year: 2001..to characterize the rate limiting molecular steps in osteoclast metabolism using chicken, rabbit and human osteoclasts. The specific aims are: I...