alveolar macrophages

Summary

Summary: Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.

Top Publications

  1. ncbi Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages
    J Keane
    Pulmonary Center, Boston University School of Medicine, Boston MA 02118, USA
    J Immunol 164:2016-20. 2000
  2. pmc Identification of an autophagy defect in smokers' alveolar macrophages
    Martha M Monick
    Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 185:5425-35. 2010
  3. ncbi A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18
    Antje Prasse
    Department of Pneumology, University Hospital, Killianstr 5, 79106 Freiburg, Germany
    Am J Respir Crit Care Med 173:781-92. 2006
  4. pmc Phagocytosis and intracellular fate of Aspergillus fumigatus conidia in alveolar macrophages
    O Ibrahim-Granet
    Unite des Aspergillus, Institut Pasteur, 75724 Paris Cedex 15, France
    Infect Immun 71:891-903. 2003
  5. pmc Alveolar macrophages are a major determinant of early responses to viral lung infection but do not influence subsequent disease development
    Philippa K Pribul
    Department of Respiratory Medicine, Paddington Campus of Imperial College, Norfolk Place, London W2 1PG, United Kingdom
    J Virol 82:4441-8. 2008
  6. ncbi Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: further mechanistic studies
    Susanne Becker
    US Environmental Protection Agency, Human Studies Facility, National Health and Environmental Effects Research Laboratory, Research Triangle Park, 104 Mason Farm Road, Chapel Hill, NC 27599, USA
    Toxicol Appl Pharmacol 207:269-75. 2005
  7. ncbi PKR regulates TLR2/TLR4-dependent signaling in murine alveolar macrophages
    Maciej Cabanski
    University of Giessen Lung Center, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Infectious Diseases, Justus Liebig University, Klinikstrasse 36, Giessen 35392, Germany
    Am J Respir Cell Mol Biol 38:26-31. 2008
  8. doi Alternatively activated alveolar macrophages in pulmonary fibrosis-mediator production and intracellular signal transduction
    Dmitri V Pechkovsky
    Department of Pneumology, Medical Center, Albert Ludwigs University, Freiburg, Germany
    Clin Immunol 137:89-101. 2010
  9. pmc The prolonged life-span of alveolar macrophages
    Jaime Murphy
    The Pulmonary Center, R 304, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Am J Respir Cell Mol Biol 38:380-5. 2008
  10. ncbi Apoptosis genes in human alveolar macrophages infected with virulent or attenuated Mycobacterium tuberculosis: a pivotal role for tumor necrosis factor
    Avrum Spira
    St James s Hospital, James s St, Dublin 3, Ireland
    Am J Respir Cell Mol Biol 29:545-51. 2003

Detail Information

Publications404 found, 100 shown here

  1. ncbi Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages
    J Keane
    Pulmonary Center, Boston University School of Medicine, Boston MA 02118, USA
    J Immunol 164:2016-20. 2000
    Human alveolar macrophages (AMphi) undergo apoptosis following infection with Mycobacterium tuberculosis in vitro...
  2. pmc Identification of an autophagy defect in smokers' alveolar macrophages
    Martha M Monick
    Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 185:5425-35. 2010
    b>Alveolar macrophages are essential for clearing bacteria from the alveolar surface and preventing microbe-induced infections. It is well documented that smokers have an increased incidence of infections, in particular lung infections...
  3. ncbi A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18
    Antje Prasse
    Department of Pneumology, University Hospital, Killianstr 5, 79106 Freiburg, Germany
    Am J Respir Crit Care Med 173:781-92. 2006
    ..Recently, models of macrophage activation have been revised. Macrophages stimulated with Th2 cytokines have been classified as alternatively activated...
  4. pmc Phagocytosis and intracellular fate of Aspergillus fumigatus conidia in alveolar macrophages
    O Ibrahim-Granet
    Unite des Aspergillus, Institut Pasteur, 75724 Paris Cedex 15, France
    Infect Immun 71:891-903. 2003
    ..Upon arrival in the lung alveolus, conidia of A. fumigatus are phagocytosed by alveolar macrophages, the major phagocytic cells of the lung. Engulfment and intracellular trafficking of A...
  5. pmc Alveolar macrophages are a major determinant of early responses to viral lung infection but do not influence subsequent disease development
    Philippa K Pribul
    Department of Respiratory Medicine, Paddington Campus of Imperial College, Norfolk Place, London W2 1PG, United Kingdom
    J Virol 82:4441-8. 2008
    ..Therefore, lung macrophages play a central role in the early responses to viral infection but have remarkably little effect on the adaptive response occurring at the time of peak disease severity...
  6. ncbi Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: further mechanistic studies
    Susanne Becker
    US Environmental Protection Agency, Human Studies Facility, National Health and Environmental Effects Research Laboratory, Research Triangle Park, 104 Mason Farm Road, Chapel Hill, NC 27599, USA
    Toxicol Appl Pharmacol 207:269-75. 2005
    ..matter (PM) affect lung health, the two main airway cell types likely to interact with inhaled particles, alveolar macrophages (AM) and airway epithelial cells have been exposed to particles in vitro and followed for endpoints of ..
  7. ncbi PKR regulates TLR2/TLR4-dependent signaling in murine alveolar macrophages
    Maciej Cabanski
    University of Giessen Lung Center, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Infectious Diseases, Justus Liebig University, Klinikstrasse 36, Giessen 35392, Germany
    Am J Respir Cell Mol Biol 38:26-31. 2008
    ..In this report we investigated whether PKR is involved in TLR2/TLR4-mediated immune responses of primary alveolar macrophages (AM). We found that both TLR2 (Pam3CSK4) and TLR4 (LPS) ligands induced rapid phosphorylation of PKR...
  8. doi Alternatively activated alveolar macrophages in pulmonary fibrosis-mediator production and intracellular signal transduction
    Dmitri V Pechkovsky
    Department of Pneumology, Medical Center, Albert Ludwigs University, Freiburg, Germany
    Clin Immunol 137:89-101. 2010
    ..spontaneous production of the chemokines CCL17, CCL18 and CCL22 and increased expression of CD206 by alveolar macrophages from patients with lung fibrosis...
  9. pmc The prolonged life-span of alveolar macrophages
    Jaime Murphy
    The Pulmonary Center, R 304, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Am J Respir Cell Mol Biol 38:380-5. 2008
    To further examine the half-life of alveolar macrophages, chimeric CD 45.2 mice were generated through bone marrow transplantation of donor CD 45.1 cells...
  10. ncbi Apoptosis genes in human alveolar macrophages infected with virulent or attenuated Mycobacterium tuberculosis: a pivotal role for tumor necrosis factor
    Avrum Spira
    St James s Hospital, James s St, Dublin 3, Ireland
    Am J Respir Cell Mol Biol 29:545-51. 2003
    Tumor necrosis factor (TNF)-alpha-dependent apoptosis of alveolar macrophages (AM) after infection with avirulent Mycobacterium tuberculosis (Mtb) results in bacillary death and the destruction of a growth niche for the pathogen...
  11. ncbi YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages
    Severine Letuve
    Institut National de la Santé et de la Recherche Médicale Unité 700, Physiopathology and Epidemiology of Respiratory Insufficiency, Paris, France
    J Immunol 181:5167-73. 2008
    ..Serum, bronchoalveolar lavage (BAL), bronchial biopsies, lung tissue specimens, and alveolar macrophages from never-smokers (n = 15), smokers without COPD (n = 20), and smokers with COPD (n = 30) were assessed ..
  12. ncbi Receptors for unopsonized particles: the role of alveolar macrophage scavenger receptors
    A Palecanda
    LigoCyte Pharmaceuticals, Inc, Bozeman, MT 59718, USA
    Curr Mol Med 1:589-95. 2001
    ..We will also discuss other non-scavenger receptors involved in opsonin-independent phagocytosis...
  13. pmc Granulocyte macrophage colony stimulating factor is elevated in alveolar macrophages from sheep naturally infected with maedi-visna virus and stimulates maedi-visna virus replication in macrophages in vitro
    Z Zhang
    Department of Veterinary Pathology, University of Edinburgh, Edinburgh, UK
    Clin Exp Immunol 129:240-6. 2002
    ..macrophage-colony stimulating factor (GM-CSF) and transforming growth factor-beta1 mRNA was observed in alveolar macrophages isolated from the lungs of naturally infected animals when compared with lungs of seronegative controls...
  14. doi Porcine reproductive and respiratory syndrome virus modulates apoptosis during replication in alveolar macrophages
    Sarah Costers
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium
    Arch Virol 153:1453-65. 2008
    ..In conclusion, this study shows that PRRSV stimulates anti-apoptotic pathways in macrophages early in infection and that PRRSV-infected macrophages die by apoptosis late in infection...
  15. ncbi Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia
    Sylvia Knapp
    Laboratory of Experimental Internal Medicine, Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Am J Respir Crit Care Med 167:171-9. 2003
    b>Alveolar macrophages (AMs) are considered major effector cells in host defense against respiratory tract infections by virtue of their potent phagocytic properties...
  16. pmc Alveolar macrophages are indispensable for controlling influenza viruses in lungs of pigs
    Heui Man Kim
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, 220 Gung Dong, Yuseong Gu, Daejeon, 305 764, Korea
    J Virol 82:4265-74. 2008
    b>Alveolar macrophages constitutively reside in the respiratory tracts of pigs and humans...
  17. pmc Involvement of sialoadhesin in entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages
    Nathalie Vanderheijden
    Laboratory of Virology, Faculty of Veterinary Medicine, Flanders Interuniversity Institute of Biotechnology VIB, 5830 AA Boxmeer, The Netherlands
    J Virol 77:8207-15. 2003
    ..A monoclonal antibody (MAb) that is able to block PRRSV infection of porcine alveolar macrophages (PAM) and that recognizes a 210-kDa protein (p210) was described previously (MAb41D3) (X. Duan, H...
  18. ncbi IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma
    Chuanwang Song
    Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, The People s Republic of China
    J Immunol 181:6117-24. 2008
    ..Importantly, IL-17(+) alveolar macrophages (AMs), but not IL-17(+) interstitial macrophages, were significantly increased after allergen challenge...
  19. ncbi Alveolar macrophages from subjects with chronic obstructive pulmonary disease are deficient in their ability to phagocytose apoptotic airway epithelial cells
    Sandra Hodge
    Department of Thoracic Medicine, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5001, Australia
    Immunol Cell Biol 81:289-96. 2003
    ..epithelial cells chronic obstructive pulmonary disease in could be due to defective phagocytic clearance by alveolar macrophages. There have been no previous studies of the phagocytic capacity of alveolar macrophages in chronic ..
  20. ncbi Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses
    Yutaro Kumagai
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Immunity 27:240-52. 2007
    ..By contrast, lung infection with NDV led to IFN-alpha production in alveolar macrophages (AMs) and cDCs, but not in pDCs...
  21. ncbi Involvement of nicotinic acetylcholine receptors in suppression of antimicrobial activity and cytokine responses of alveolar macrophages to Legionella pneumophila infection by nicotine
    K Matsunaga
    Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, FL 33612, USA
    J Immunol 167:6518-24. 2001
    ..cigarette smoking, how nicotine alters the host defense of the lung and, in particular, immune responses of alveolar macrophages, which are critical effector cells in the lung defense to infection, is poorly understood...
  22. pmc Alveolar macrophages are required for protective pulmonary defenses in murine Klebsiella pneumonia: elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival
    E Broug-Holub
    Department of Cell Biology and Immunology, Vrije Universiteit, Amsterdam, The Netherlands
    Infect Immun 65:1139-46. 1997
    To study the in vivo role of alveolar macrophages (AM) in gram-negative bacterial pneumonia in mice, AM were eliminated by the intratracheal (i.t.) administration of dichloromethylene diphosphonate encapsulated liposomes...
  23. ncbi Recombinant swine beta interferon protects swine alveolar macrophages and MARC-145 cells from infection with Porcine reproductive and respiratory syndrome virus
    C Overend
    Department of Pathobiology and Veterinary Science, University of Connecticut, 61 North Eagleville Road, Storrs, CT, USA
    J Gen Virol 88:925-31. 2007
    ..swIFN-beta was also tested for antiviral activity on porcine alveolar macrophages (PAMs) obtained by bronchoalveolar lavage from PRRSV-negative swine...
  24. ncbi Alveolar macrophages as orchestrators of COPD
    Peter J Barnes
    National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse St, SW3 6LY, London, UK
    COPD 1:59-70. 2004
    b>Alveolar macrophages play a critical role in the pathophysiology of COPD and are a major target for future anti-inflammatory therapy...
  25. pmc The PB1-F2 protein of Influenza A virus: increasing pathogenicity by disrupting alveolar macrophages
    J Robert Coleman
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA
    Virol J 4:9. 2007
    ..This protein has been shown to specifically target and destroy alveolar macrophages 2...
  26. ncbi Differential particulate air pollution induced oxidant stress in human granulocytes, monocytes and alveolar macrophages
    S Becker
    US EPA, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    Toxicol In Vitro 16:209-18. 2002
    ..cells in the airways including neutrophils (PMN), eosinophils and monocytes (Mo), and increased numbers of alveolar macrophages (AM)...
  27. pmc Inflammasome recognition of influenza virus is essential for adaptive immune responses
    Takeshi Ichinohe
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:79-87. 2009
    ..These results demonstrate that in addition to the TLR pathways, ASC inflammasomes play a central role in adaptive immunity to influenza virus...
  28. ncbi Acetaminophen decreases intracellular glutathione levels and modulates cytokine production in human alveolar macrophages and type II pneumocytes in vitro
    Svetlana Dimova
    Laboratory of Pneumology, Unit of Toxicology, K U Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Int J Biochem Cell Biol 37:1727-37. 2005
    ..of cytochrome P450 or prostaglandin H synthetase, and TNF-alpha, IL-6 and IL-8 protein production in human alveolar macrophages and type II pneumocytes in vitro...
  29. ncbi MARCO mediates silica uptake and toxicity in alveolar macrophages from C57BL/6 mice
    Raymond F Hamilton
    Department of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, Missoula, Montana 59812, USA
    J Biol Chem 281:34218-26. 2006
    ..findings indicated that MARCO was the critical SR involved in silica uptake and cytotoxicity in the primary alveolar macrophages (AM) from C57BL/6 mice, as there was no particle uptake or cell death in the absence of this SR...
  30. pmc Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase
    Carlos H C Serezani
    Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0642, USA
    Blood 106:1067-75. 2005
    ..We sought to investigate the importance of LTs in regulating the microbicidal activity of alveolar macrophages (AMs) and the molecular mechanisms by which this occurs...
  31. ncbi Induction of inducible nitric oxide synthase by lipopolysaccharide/interferon gamma and sepsis down-regulates 5-lipoxygenase metabolism in murine alveolar macrophages
    Michael Coffey
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    Exp Lung Res 30:615-33. 2004
    ..Treatment of alveolar macrophages from inducible NO synthase (iNOS) wild-type but not knock-out mice with LPS inhibited leukotriene synthesis...
  32. pmc Porcine arterivirus infection of alveolar macrophages is mediated by sialic acid on the virus
    Peter L Delputte
    Department of Virology, Faculty of Veterinary Medicine, Belgium
    J Virol 78:8094-101. 2004
    ..mediates internalization of the arterivirus porcine reproductive and respiratory syndrome virus (PRRSV) in alveolar macrophages (Vanderheijden et al., J. Virol. 77:8207-8215, 2003)...
  33. ncbi Mycobacterium tuberculosis: here today, and here tomorrow
    D G Russell
    Microbiology and Immunology, 5173 Veterinary Medical Center, Cornell University, Ithaca, New York 14853, USA
    Nat Rev Mol Cell Biol 2:569-77. 2001
    ..As the macrophage is key to clearing the infection, the interplay between the pathogen and its host cell reflects a constant battle for control...
  34. ncbi T(H)2-mediated pulmonary inflammation leads to the differential expression of ribonuclease genes by alveolar macrophages
    Stephania A Cormier
    Divisions of Hematology Oncology and Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, S C Johnson Medical Research Center, Scottsdale, Arizona 85259, USA
    Am J Respir Cell Mol Biol 27:678-87. 2002
    ..that despite an allergen-mediated pulmonary eosinophilia and earlier studies showing that Ears are constituents of eosinophil secondary granules, alveolar macrophages are a significant source of these RNases in lungs of OVA-treated mice.
  35. ncbi Surface components of airborne particulate matter induce macrophage apoptosis through scavenger receptors
    Chrysanthus J Obot
    Environmental Toxicology, Texas Southern University, Houston 77004, USA
    Toxicol Appl Pharmacol 184:98-106. 2002
    ..These results may also help explain why PM from many different sources, with differences in composition, are all bioactive, since it is the overall matrix that is important, not just one component...
  36. ncbi Cholesterol-rich membrane rafts and Lyn are involved in phagocytosis during Pseudomonas aeruginosa infection
    Shibichakravarthy Kannan
    Department of Biochemistry and Molecular Biology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    J Immunol 180:2396-408. 2008
    ..Blocking of Lyn or blocking of cholesterol synthesis significantly inhibited phagocytosis by alveolar macrophages. We found that Lyn, via Src homology 2 and 3 domains, bound to and then activated PI3K and Akt to regulate ..
  37. ncbi Quantitative analysis of maedi-visna virus DNA load in peripheral blood monocytes and alveolar macrophages
    Z Zhang
    Department of Veterinary Pathology, University of Edinburgh, Edinburgh, UK
    J Virol Methods 86:13-20. 2000
    ..MVV DNA levels in peripheral blood monocytes and alveolar macrophages from MVV-infected sheep (n=12) were assessed by QC-PCR...
  38. ncbi Th type 1-stimulating activity of lung macrophages inhibits Th2-mediated allergic airway inflammation by an IFN-gamma-dependent mechanism
    C Tang
    Asthma Research Group, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 166:1471-81. 2001
    ....
  39. ncbi Activation of E-prostanoid4 and E-prostanoid2 receptors inhibits TNF-alpha release from human alveolar macrophages
    M J Ratcliffe
    Dept of Molecular Biology, AstraZeneca Research and Development Charnwood, Bakewell Road, Loughborough, LE11 5RH, UK
    Eur Respir J 29:986-94. 2007
    Prostaglandin (PG)E(2) has been shown to inhibit mediator release from human alveolar macrophages (AMs), but the prostanoid receptor(s) mediating this response have not yet been documented...
  40. ncbi N-Acetyl-L-cysteine and pyrrolidine dithiocarbamate inhibited nuclear factor-kappaB activation in alveolar macrophages by different mechanisms
    Ya qing Li
    Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Acta Pharmacol Sin 27:339-46. 2006
    ..dithiocarbamate (PDTC) on the phosphorylation of IkappaB kinase (IKK) beta, IKK alpha, and IkB alpha in alveolar macrophages (AM), and to explore the pharmacological mechanisms of NAC and PDTC as inhibitors of NF-kappaB activation.
  41. ncbi Lipid-laden alveolar macrophages (LLAM): a useful marker of silent aspiration in children
    P Ahrens
    Department of Pediatrics, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Pediatr Pulmonol 28:83-8. 1999
    ..75 years) for the presence of lipid-laden alveolar macrophages. We compared children with chronic chest disease (CCD) and GER to healthy surgical controls without known ..
  42. pmc Anionic pulmonary surfactant phospholipids inhibit inflammatory responses from alveolar macrophages and U937 cells by binding the lipopolysaccharide-interacting proteins CD14 and MD-2
    Koji Kuronuma
    Department of Medicine, Program in Cell Biology, National Jewish Health, Denver, Colorado 80206, USA
    J Biol Chem 284:25488-500. 2009
    ..pulmonary surfactant, and synthetic dimyristoylphosphatidylglycerol regulated the inflammatory response of alveolar macrophages. The anionic lipids significantly inhibited LPS-induced nitric oxide and tumor necrosis factor-alpha ..
  43. pmc Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages
    Andrew A Wilson
    Pulmonary Center and Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    J Clin Invest 120:379-89. 2010
    ..an intratracheally instilled lentiviral system able to deliver genes selectively to as many as 70% of alveolar macrophages (AMs) in the mouse lung...
  44. doi Cloning and identification of microRNAs in bovine alveolar macrophages
    Guangxian Xu
    College of Life Science, Ningxia University, Xixia District, Yinchuan, Ningxia, 750021, China
    Mol Cell Biochem 332:9-16. 2009
    ..These results add to the growing database of new miRNAs and suggest new biological functions for miRNAs in AMs. Specially, our data implicates miRNA regulation of antimicrobial targets in alveolar macrophages of bovine lung.
  45. pmc Role of Toll-like receptors in activation of porcine alveolar macrophages by porcine reproductive and respiratory syndrome virus
    Laura C Miller
    Virus and Prion Diseases of Livestock Research Unit, USDA, Agricultural Research Service, National Animal Disease Center, Ames, Iowa 50010, USA
    Clin Vaccine Immunol 16:360-5. 2009
    ..and respiratory syndrome virus (PRRSV), a positive-sense RNA virus, initiates infection in porcine alveolar macrophages (PAMs), elicits weak immune responses, and establishes a persistent infection...
  46. ncbi CFTR regulates phagosome acidification in macrophages and alters bactericidal activity
    Anke Di
    Dept of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, IL 60637, USA
    Nat Cell Biol 8:933-44. 2006
    ..Here, we show that in alveolar macrophages the cystic fibrosis transmembrane conductance regulator Cl- channel (CFTR) participates in phagosomal pH ..
  47. ncbi Continuous porcine cell lines developed from alveolar macrophages: partial characterization and virus susceptibility
    H M Weingartl
    NCFAD, CFIA, 1015 Arlington St, Winnipeg, MB, Canada R3E 3M4
    J Virol Methods 104:203-16. 2002
    ..Immunol. Immunopathol. 74 (2000) 163) in all three cell lines. The porcine myelomonocytic cell lines obtained may have a wide variety of applications in porcine virology and immunology...
  48. pmc Cdc42 and RhoB activation are required for mannose receptor-mediated phagocytosis by human alveolar macrophages
    Jianmin Zhang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Mol Biol Cell 16:824-34. 2005
    Human alveolar macrophages (AMs) phagocytose Pneumocystis (Pc) organisms predominantly through mannose receptors, although the molecular mechanism mediating this opsonin-independent process is not known...
  49. pmc Measles virus infection of alveolar macrophages and dendritic cells precedes spread to lymphatic organs in transgenic mice expressing human signaling lymphocytic activation molecule (SLAM, CD150)
    Claudia S Antunes Ferreira
    Department of Molecular Medicine, and Virology and Gene Therapy Track, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Virol 84:3033-42. 2010
    ..One day after inoculation, MV replication was documented only in the airways, in about 2.5% of alveolar macrophages (AM) and 0.5% of dendritic cells (DC)...
  50. pmc Surfactant protein A modulates cell surface expression of CR3 on alveolar macrophages and enhances CR3-mediated phagocytosis
    Malgorzata Gil
    Department of Pediatrics, Division of Critical Care Medicine, University of Florida, Gainesville, Florida 32610, USA
    J Biol Chem 284:7495-504. 2009
    ..Complement receptors (CR), CR3 (CD11b), and CR4 (CD11c) were expressed at reduced levels on the surface of alveolar macrophages from Sp-a(-/-) compared with Sp-a(+/+) mice...
  51. pmc Alveolar macrophage-mediated killing of Pneumocystis carinii f. sp. muris involves molecular recognition by the Dectin-1 beta-glucan receptor
    Chad Steele
    Department of Pediatrics, Division of Pulmonology, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Exp Med 198:1677-88. 2003
    ..carinii by alveolar macrophages is mediated by the Dectin-1 beta-glucan receptor and that the subsequent generation of hydrogen peroxide is ..
  52. doi CCL18 production is decreased in alveolar macrophages from cigarette smokers
    Florian Kollert
    Department of Pneumology, Medical Center, Albert Ludwigs University, Freiburg, Germany
    Inflammation 32:163-8. 2009
    It is generally known that cigarette smoke alters the activation of alveolar macrophages (AM). CC Chemokine Ligand 18 (CCL18) is a marker of alternatively activated macrophages and is highly expressed in the lung...
  53. pmc Effects of prostaglandin E2 on the subcellular localization of Epac-1 and Rap1 proteins during Fcgamma-receptor-mediated phagocytosis in alveolar macrophages
    Thomas G Brock
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, The University of Michigan Health System, Ann Arbor, MI 48109, USA
    Exp Cell Res 314:255-63. 2008
    ..Therefore, we used immunofluorescent techniques and phagosome isolation to localize Epac-1 and Rap1 in alveolar macrophages. Epac-1 was predominantly expressed on punctate and tubular membranes throughout the cell body; on the ..
  54. pmc Disease-causing mutations in the cystic fibrosis transmembrane conductance regulator determine the functional responses of alveolar macrophages
    Ludmila V Deriy
    Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 284:35926-38. 2009
    b>Alveolar macrophages (AMs) play a major role in host defense against microbial infections in the lung...
  55. pmc Glucocorticoid sensitivity of lipopolysaccharide-stimulated chronic obstructive pulmonary disease alveolar macrophages
    J Armstrong
    University of Manchester, NIHR Translational Research Facility, University Hospital of South Manchester Foundation Trust, Manchester, UK
    Clin Exp Immunol 158:74-83. 2009
    It has been reported that alveolar macrophages from patients with chronic obstructive pulmonary disease (COPD) display glucocorticoid (Gc) resistance. The Gc sensitivity of inflammatory mediators released by COPD macrophages may vary...
  56. pmc Cell size of alveolar macrophages: an interspecies comparison
    F Krombach
    Institute for Surgical Research, University of Munich, Germany
    Environ Health Perspect 105:1261-3. 1997
    b>Alveolar macrophages (AM) play a critical role in the removal of inhaled particles or fibers from the lung...
  57. ncbi Azithromycin increases phagocytosis of apoptotic bronchial epithelial cells by alveolar macrophages
    S Hodge
    Dept of Thoracic Medicine, Royal Adelaide Hospital and Lung Research Laboratory, Hanson Institute, Adelaide, Australia
    Eur Respir J 28:486-95. 2006
    ..Its effects may be increased in the lung due to its ability to reach high concentrations in alveolar macrophages (AMs)...
  58. pmc Induction of gamma interferon production in human alveolar macrophages by Mycobacterium tuberculosis
    M J Fenton
    Pulmonary Center, Boston University School of Medicine, Massachusetts 02118, USA
    Infect Immun 65:5149-56. 1997
    ..demonstrations that it can be produced by murine macrophages prompted us to examine the capacity of human alveolar macrophages to express IFN-gamma. Here we report that in vitro infection of alveolar macrophages with M...
  59. pmc Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infection
    Monica M Mircescu
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, New York, USA
    J Infect Dis 200:647-56. 2009
    b>Alveolar macrophages and neutrophils mediate innate immune defense against the opportunistic fungal pathogen Aspergillus fumigatus and are believed to be essential for host survival following inhalation of fungal spores (conidia)...
  60. pmc Alveolar macrophages transport pathogens to lung draining lymph nodes
    Alun C Kirby
    Department of Biology, Centre for Immunology and Infection, Hull York Medical School, University of York, York, United Kingdom
    J Immunol 183:1983-9. 2009
    ..However, alveolar macrophages (AM) are the first phagocytes to contact inhaled particulate matter...
  61. ncbi Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages
    S D Shapiro
    Department of Medicine, Jewish Hospital, Washington University Medical Center, St Louis, Missouri 63110
    J Biol Chem 268:23824-9. 1993
    Human alveolar macrophages have the capacity to degrade elastin...
  62. ncbi Interferon-alpha response to swine arterivirus (PoAV), the porcine reproductive and respiratory syndrome virus
    E Albina
    CNEVA Ploufragan, Unité de Virologie et Immunologie Porcines, France
    J Interferon Cytokine Res 18:485-90. 1998
    ..In vitro, PoAV replicates in alveolar macrophages, but neither these nor peripheral blood mononuclear cells (PBMC) produced IFN-alpha in response to ..
  63. pmc Increased production of proinflammatory cytokines following infection with porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae
    Roongroje Thanawongnuwech
    Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA 50011, USA
    Clin Diagn Lab Immunol 11:901-8. 2004
    ..IL-1) (alpha and beta), IL-6, IL-8, IL-10, IL-12, and tumor necrosis factor alpha (TNF-alpha) in pulmonary alveolar macrophages (PAMs) was assessed following experimental infection with porcine reproductive and respiratory syndrome ..
  64. ncbi Gm-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense
    Bruce C Trapnell
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Annu Rev Physiol 64:775-802. 2002
    ..b>Alveolar macrophages from GM(-/-) mice have reduced capacity for surfactant catabolism, cell adhesion, phagocytosis, bacterial ..
  65. pmc Pseudomonas aeruginosa LPS or flagellin are sufficient to activate TLR-dependent signaling in murine alveolar macrophages and airway epithelial cells
    Eloïse Raoust
    Unité de Défense Innée et Inflammation, Institut Pasteur, Paris, France
    PLoS ONE 4:e7259. 2009
    ..Based on whole animal experiments, using TLR knockout mice, the control of this bacterium is believed to occur by the recognition of LPS and flagellin by TLRs 2,4 and 5, respectively...
  66. ncbi Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense
    Sylvia Knapp
    Laboratory of Experimental Internal Medicine, Department of Pathology, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 172:3132-8. 2004
    ..These data suggest that TLR2 plays a limited role in the innate immune response to pneumococcal pneumonia, and that additional pattern recognition receptors likely are involved in host defense against this common respiratory pathogen...
  67. ncbi Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of beta-catenin
    M M Monick
    Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 166:4713-20. 2001
    Exposure of human alveolar macrophages to bacterial LPS results in activation of a number of signal transduction pathways...
  68. pmc The relative susceptibility of mouse strains to pulmonary Cryptococcus neoformans infection is associated with pleiotropic differences in the immune response
    Oscar Zaragoza
    Departments of Microbiology and Immunology and Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Infect Immun 75:2729-39. 2007
    ....
  69. pmc Particulate matter exposure induces persistent lung inflammation and endothelial dysfunction
    Eiji Tamagawa
    Division of Respiratory Medicine, University of British Columbia and James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Physiol Lung Cell Mol Physiol 295:L79-85. 2008
    ..This suggests that PM-induced lung and systemic inflammatory responses contribute to the adverse vascular events associated with exposure to air pollution...
  70. doi Different doses of lipopolysaccharides regulate the lung inflammation of asthmatic mice via TLR4 pathway in alveolar macrophages
    Liang Dong
    Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China
    J Asthma 46:229-33. 2009
    ..Regardless of high or low dose of LPS, TLR4 in alveolar macrophages (AM) was up-regulated in lungs of asthmatic mice...
  71. ncbi Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin mediates binding and internalization of Aspergillus fumigatus conidia by dendritic cells and macrophages
    Diego Serrano-Gomez
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Immunol 173:5635-43. 2004
    ..The clinical relevance of this interaction is emphasized by the presence of DC-SIGN in lung DC and alveolar macrophages, and further illustrated by the DC-SIGN-dependent attachment of A...
  72. ncbi Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages
    Chiu Yuan Chen
    Graduate Institute of Chinese Pharmaceutical Sciences, China Medical University, Taichung 404, Taiwan, ROC
    Life Sci 81:1602-14. 2007
    ..NF-kappaB and AP-1 activation, luteolin acts to suppress the LPS-elicited inflammatory events in mouse alveolar macrophages, and this effect was mediated, at least in part, by inhibiting the generation of reactive oxygen species...
  73. ncbi Regulation of interleukin-8 expression in porcine alveolar macrophages by bacterial lipopolysaccharide
    G Lin
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul 55108
    J Biol Chem 269:77-85. 1994
    ..Hence, expression of IL-8 by alveolar macrophages may be a significant factor in host defense in the lung and in the pathogenesis of pneumonia in swine...
  74. pmc Nontypeable Haemophilus influenzae clearance by alveolar macrophages is impaired by exposure to cigarette smoke
    Pau Martí-Lliteras
    Programa de Infección e Inmunidad, Fundación Caubet CIMERA, Recinto Hospital Joan March, Bunyola, Spain
    Infect Immun 77:4232-42. 2009
    ..Glucocorticoids, which are anti-inflammatory drugs, are still the most common therapy for these diseases. Alveolar macrophages are professional phagocytes that reside in the lung and are responsible for clearing infections by the ..
  75. ncbi Innate immune responses to replication of porcine reproductive and respiratory syndrome virus in isolated Swine alveolar macrophages
    Tahar Ait-Ali
    Roslin Institute, Roslin, Midlothian, United Kingdom
    Viral Immunol 20:105-18. 2007
    ..In this study, alveolar macrophages derived from five commercial pig lines were used to study the innate immune response to PRRSV infection in ..
  76. pmc Depletion of alveolar macrophages decreases the dissemination of a glucosylceramide-deficient mutant of Cryptococcus neoformans in immunodeficient mice
    Talar B Kechichian
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    Infect Immun 75:4792-8. 2007
    ..neoformans glucosylceramide in a T- and NK-cell-immunodeficient mouse model (Tgepsilon26) in which alveolar macrophages (AMs) are not activated and granuloma formation is not expected...
  77. ncbi Impaired phagocytosis of nontypeable Haemophilus influenzae by human alveolar macrophages in chronic obstructive pulmonary disease
    Charles S Berenson
    Division of Infectious Diseases, Department of Veterans Affairs Western New York Healthcare System, State University of New York at Buffalo School of Medicine, Buffalo, NY 14215, USA
    J Infect Dis 194:1375-84. 2006
    Interactions of nontypeable Haemophilus influenzae (NTHI) with human alveolar macrophages are implicated in the persistence of NTHI in chronic obstructive pulmonary disease (COPD)...
  78. ncbi Macrophage defences against respiratory tract infections
    S B Gordon
    Wellcome Trust Research Laboratory, University of Malawi, Queen Elizabeth Central Hospital, Blantyre, Malawi
    Br Med Bull 61:45-61. 2002
    ..Macrophage function can be modulated by cytokines, environmental exposures, recent and chronic infection including HIV infection, drug therapy and gene transfer...
  79. ncbi Cigarette smoke exposure attenuates cytokine production by mouse alveolar macrophages
    Gordon J Gaschler
    McMaster University, Department of Pathology and Molecular Medicine, 1200 Main Street West, Hamilton, ON, L8N 3Z5 Canada
    Am J Respir Cell Mol Biol 38:218-26. 2008
    b>Alveolar macrophages (aMs) play a central role in respiratory host defense by sensing microbial antigens and initiating immune-inflammatory responses early in the course of an infection...
  80. pmc Role of dendritic cells and alveolar macrophages in regulating early host defense against pulmonary infection with Cryptococcus neoformans
    John J Osterholzer
    Pulmonary Section, VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48105, USA
    Infect Immun 77:3749-58. 2009
    ..an established model of diphtheria toxin-mediated depletion of resident pulmonary dendritic cells (DC) and alveolar macrophages (AM) was used to assess the contribution of these cells to the initial host response against cryptococcal ..
  81. pmc Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation
    Elizabeth F Redente
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    J Leukoc Biol 88:159-68. 2010
    b>Alveolar macrophages and BDMCs undergo sequential biochemical changes during the chronic inflammatory response to chemically induced lung carcinogenesis in mice...
  82. pmc The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles
    Mohamed Arredouani
    Physiology Program, Harvard School of Public Health, 665 Huntington Ave, SPH II, Rm 221, Boston, MA 02115, USA
    J Exp Med 200:267-72. 2004
    b>Alveolar macrophages (AMs) express the class A scavenger receptor macrophage receptor with collagenous structure (MARCO), but its role in vivo in lung defense against bacteria and environmental particles has not been studied...
  83. pmc Ron receptor tyrosine kinase negatively regulates TNFalpha production in alveolar macrophages by inhibiting NF-kappaB activity and Adam17 production
    Nikolaos M Nikolaidis
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
    Shock 33:197-204. 2010
    ..the alterations observed in the Ron TK(-/-) mice may be due, in part, to Ron signaling, specifically in alveolar macrophages. To test this hypothesis, we used the wild-type and Ron TK(-/-) primary alveolar macrophages and the murine ..
  84. pmc Surfactant proteins A and D enhance pulmonary clearance of Pseudomonas aeruginosa
    Eric Giannoni
    Department of Pediatrics, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 0110, USA
    Am J Respir Cell Mol Biol 34:704-10. 2006
    ..Phagocytosis of the bacteria by alveolar macrophages was decreased in SP-A-/- and SP-D-/- mice...
  85. pmc In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma
    Leonie S van Rijt
    Department of Pulmonary Medicine, Erasmus MC, 3015 GE Rotterdam, Netherlands
    J Exp Med 201:981-91. 2005
    ..Airway administration of DT depleted CD11c(+) DCs and alveolar macrophages and abolished the characteristic features of asthma, including eosinophilic inflammation, goblet cell ..
  86. ncbi Gene expression profiling of human alveolar macrophages of phenotypically normal smokers and nonsmokers reveals a previously unrecognized subset of genes modulated by cigarette smoking
    Adriana Heguy
    Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Mol Med (Berl) 84:318-28. 2006
    ..While the pathogenesis of COPD is complex, there is abundant evidence that alveolar macrophages (AM) play an important role...
  87. doi Deletion of PPAR gamma in alveolar macrophages is associated with a Th-1 pulmonary inflammatory response
    Anagha Malur
    Department of Internal Medicine, Division of Pulmonary and Critical Care and Sleep Medicine, East Carolina University, Greenville, NC 27834, USA
    J Immunol 182:5816-22. 2009
    ..proliferator-activated receptor gamma (PPARgamma) is constitutively expressed at high levels in healthy alveolar macrophages, in contrast to other tissue macrophages and blood monocytes...
  88. ncbi Peroxisome proliferator-activated receptor gamma activity is deficient in alveolar macrophages in pulmonary sarcoidosis
    Daniel A Culver
    Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Respir Cell Mol Biol 30:1-5. 2004
    ..in chronic sarcoidosis, a disease characterized by persistent activation of Th1 immune responses in alveolar macrophages. We hypothesized that a deficiency of PPAR gamma activity contributes to ongoing inflammation in pulmonary ..
  89. ncbi Surfactant protein A inhibits peptidoglycan-induced tumor necrosis factor-alpha secretion in U937 cells and alveolar macrophages by direct interaction with toll-like receptor 2
    Seiji Murakami
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    J Biol Chem 277:6830-7. 2002
    ..significantly reduced PGN-elicited tumor necrosis factor alpha (TNF-alpha) secretion by U937 cells and rat alveolar macrophages. The inhibitory effect on TNF-alpha secretion was dependent upon SP-A concentrations in physiological range...
  90. pmc Silica binding and toxicity in alveolar macrophages
    Raymond F Hamilton
    Department of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, 32 Campus Drive, SB 154, Missoula, MT 59812, USA
    Free Radic Biol Med 44:1246-58. 2008
    ..Current research ideas on silica toxicity and binding in the alveolar macrophage are reviewed and discussed...
  91. ncbi Crosstalk between prostaglandin E2 and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP
    Sang Pyo Lee
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Immunol 182:530-7. 2009
    ....
  92. ncbi Respiratory burst: role in signal transduction in alveolar macrophages
    Maureen R Gwinn
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health B Crit Rev 9:27-39. 2006
    b>Alveolar macrophages play an important role in defense against airborne pathogens and particles...
  93. doi Mannan-modified solid lipid nanoparticles for targeted gene delivery to alveolar macrophages
    Wangyang Yu
    School of Pharmaceutical Sciences, Shandong University, 44 Wen Hua Xi Road, Ji Nan, 250012, Shandong Province, People s Republic of China
    Pharm Res 27:1584-96. 2010
    ..One major problem with SLN is the lack of cell-targeting ability. In the present study, a mannan-based PE-grafted ligand was synthesized and used for the surface modification of DNA-loaded cationic SLN to prepare Man-SLN-DNA...
  94. ncbi Rifampicin concentrations in bronchial mucosa, epithelial lining fluid, alveolar macrophages and serum following a single 600 mg oral dose in patients undergoing fibre-optic bronchoscopy
    Hisham M Ziglam
    Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    J Antimicrob Chemother 50:1011-5. 2002
    The concentrations of rifampicin in epithelial lining fluid (ELF), human alveolar macrophages (AM), bronchial mucosal biopsies and serum were measured after a single oral dose of 600 mg rifampicin from 15 patients undergoing fibre-optic ..
  95. pmc Innate immune responses to lung-stage helminth infection induce alternatively activated alveolar macrophages
    Joshua J Reece
    W H Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Infect Immun 74:4970-81. 2006
    ..Immunohistochemistry revealed that nearly all alveolar macrophages became YM1-producing AAMs as early as day 2 postinfection...
  96. ncbi Residual oil fly ash increases the susceptibility to infection and severely damages the lungs after pulmonary challenge with a bacterial pathogen
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS 2015, Morgantown, West Virginia 26505, USA
    Toxicol Sci 70:110-9. 2002
    ..These results suggest that pulmonary exposure to ROFA may alter AM function and lead to increased susceptibility to lung infection in exposed populations...
  97. ncbi Increased release of ferritin and iron by iron-loaded alveolar macrophages in cigarette smokers
    L J Wesselius
    Division of Pulmonary and Critical Care Medicine, University of Kansas School of Medicine, Missouri
    Am J Respir Crit Care Med 150:690-5. 1994
    ..tract of cigarette smokers contains an increased amount of iron that is predominantly sequestered within alveolar macrophages (AM), but is also present in alveolar epithelial fluid...
  98. ncbi Suppression of phagocytic and bactericidal functions of rat alveolar macrophages by the organic component of diesel exhaust particles
    Xuejun J Yin
    School of Medicine, West Virginia University, Morgantown, West Virginia 26506 9203, USA
    J Toxicol Environ Health A 70:820-8. 2007
    ..monocytogenes and an increased susceptibility of the lung to bacterial infection...
  99. pmc MyD88-dependent TLR4 signaling is selectively impaired in alveolar macrophages from asymptomatic HIV+ persons
    Souvenir D Tachado
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Blood 115:3606-15. 2010
    b>Alveolar macrophages (AMs) are the predominant effector cell in the lungs and contribute to a critical first line of defense against bacterial pathogens through recognition by pattern recognition receptors such as Toll-like receptor 4 (..
  100. ncbi Alveolar macrophages from human immunodeficiency virus-infected persons demonstrate impaired oxidative burst response to Pneumocystis carinii in vitro
    H Koziel
    Division of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Respir Cell Mol Biol 23:452-9. 2000
    ..carinii. A specific impairment of P. carinii-mediated AM oxidative burst in persons with advanced HIV infection may contribute to the pathogenesis of P. carinii pneumonia...
  101. ncbi Aggregates of ultrafine particles impair phagocytosis of microorganisms by human alveolar macrophages
    Margot Lundborg
    Division of Physiology, The National Institute of Environmental Medicine, Karolinska Institutet, P O Box 287, SE 171 77 Stockholm, Sweden
    Environ Res 100:197-204. 2006
    We investigated whether exposure of alveolar macrophages to aggregates of ultrafine carbon particles affected subsequent phagocytosis of microorganisms...

Research Grants72

  1. Effect of PPARy Ligands on Alcohol-Induced Alveolar Macrophage Oxidative Stress
    Samantha M Yeligar; Fiscal Year: 2013
    ..In alveolar macrophages (AMs), NADPH oxidase (Nox) 1, Nox2, and Nox4 are critical sources of reactive oxygen species (ROS), and ..
  2. Characterizing TLR Function of Human Dendritic Cells in the Elderly
    Alexander Panda; Fiscal Year: 2012
    ..plans for establishing his independent research program, a pilot study of TLR function in lung-derived alveolar macrophages in bronchoalveolar lavage fluid from young and older individuals will be carried out to obtain pilot data...
  3. Regulation of vaccine-induced anti-fungal T17 cells
    MARCEL WUETHRICH; Fiscal Year: 2013
    ..Vaccine-induced T17 cells mediated protection by recruiting and activating neutrophils and alveolar macrophages to the alveolar space to augment fungal killing...
  4. Impact of Diabetes and Hyperlipidemia on Host Defense
    Hardy Kornfeld; Fiscal Year: 2013
    ..Diabetic mice are slow to develop aggregates of myeloid cells around Mtb-infected alveolar macrophages (AMF) and slow to deliver bacilli to the thoracic lymph nodes (TLN) where immunity is primed...
  5. DHA attenuates Inflammatory Responses Through Altering RAGE Signaling
    LYNETTE KAY ROGERS; Fiscal Year: 2013
    ..RAGE is highly expressed in lung;specifically epithelial type I cells, endothelial cells, and alveolar macrophages. RAGE protein expression is increased in the lungs of mice exposed to hyperoxia, and the increase is ..
  6. Pulmonary Defenses Against Intracellular Infection
    Shawn J Skerrett; Fiscal Year: 2013
    ..Legionella pneumophila (Lp) is an important cause of bacterial pneumonia and an intracellular pathogen of alveolar macrophages (AM)...
  7. Macrophage-based Human Gene Therapy for Hereditary PAP
    Bruce C Trapnell; Fiscal Year: 2012
    ..The disease is characterized by the progressive accumulation of surfactant in alveolar macrophages (AM) and alveoli, resulting in respiratory insufficiency and, in severe cases, respiratory failure...
  8. Chronic Granulomatous Lung Inflammation Elicited by Carbon Nanotubes
    Mary Jane Thomassen; Fiscal Year: 2013
    ..PPAR?, a negative regulator of inflammation, is constitutively expressed in healthy alveolar macrophages but deficient in severe sarcoidosis...
  9. Molecular regulation of GM-CSF expression in alveolar epithelial cells
    Robert Paine; Fiscal Year: 2013
    ..GM-CSF is essential for normal function of alveolar macrophages, critical components of the pulmonary innate immunity that are also responsible for maintenance of normal ..
  10. MNEI/SerpinB1: A modulator of innate pulmonary defense
    EILEEN REMOLD-O'DONNELL; Fiscal Year: 2010
    ..SP-D, which is required for bacterial uptake and clearance of apoptotic neutrophils by alveolar macrophages, is found as inactive fragments in lungs of Pseudomonas-infected mice lacking mnei/serpinb1...
  11. Development of an effective therapy against post-exposure Anthrax
    Maurizio Pellecchia; Fiscal Year: 2010
    ..Upon inhalation, the Anthrax spores adhere to the alveolar macrophages and germinate...
  12. Mechanisms for Cardiovascular Effects of air pollutants: Effect of Age and Sex
    BRITT HOLMEN; Fiscal Year: 2010
    ..g. dendritic cells, alveolar macrophages, CD4+ T cells) induced after exposures to engine exhaust, and determine the effects of chronic exposure to ..
  13. Environmental Chitin Exposure in the Pathogenesis of Asthma
    Rene M Roy; Fiscal Year: 2012
    ..response to chitin, (2) elucidate the role of chitin-exposed epithelial cells alternatively activating alveolar macrophages and (3) identify the role of chitin exposure in polarizing allergen specific T-cell responses in a fungal ..
  14. HIV and CD16+ monocytes as cellular reservoir &HIV/pulmonary hypertension
    Sharilyn Almodovar; Fiscal Year: 2013
    ..Peripheral blood CD16+ monocytes resemble alveolar macrophages, and undergo transendothelial migration when infected with HIV...
  15. Cigarette Smoke-derived Electrophilic Aldehydes and Airway Inflammation
    Albert van Der Vliet; Fiscal Year: 2013
    ..Our recent studies in mice have demonstrated immunosuppressive effects of acrolein on alveolar macrophages that mimic those of CS...
  16. Developing Nrf2 as a target for treatment of corticosteroid resistance in COPD
    Robert A Wise; Fiscal Year: 2012
    ..b>Alveolar macrophages and peripheral lung tissue show significant decline in HDAC2 levels with progression of COPD...
  17. Mechanistic study of the host defense functions of IL-32 in tuberculosis
    Edward D Chan; Fiscal Year: 2013
    ..in humans, we will test the efficacy of IL-32 against a virulent clinical strain of MTB in primary human alveolar macrophages (AM)...
  18. Mechanisms of airborne particulate matter induced thrombosis
    Gokhan M Mutlu; Fiscal Year: 2013
    ..that activation of the sympathetic nervous system in response to PM augments the release of IL-6 from alveolar macrophages and contributes to resulting prothrombotic state...
  19. Enhancing Nrf2 by Sulforaphane Treatment in COPD
    Robert A Wise; Fiscal Year: 2012
    ..of sulforaphane by COPD patients will increase Nrf2 activity and expression of downstream antioxidants in alveolar macrophages and bronchial epithelial cells...
  20. Cu,Zn-SOD, MMP-9, and Asbestosis
    A Brent Carter; Fiscal Year: 2013
    ..extended periods of time, which leads to the release of reactive oxygen species (ROS), including H2O2, from alveolar macrophages. The release of H2O2 by alveolar macrophages plays an integral role in the pathogenesis of aberrant matrix ..
  21. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2013
    ..neutrophils produce IL-17A and IL-17F in the lungs during bacterial pneumonia;and (5) NLRP6 knockdown human alveolar macrophages produce attenuated levels of IL-1[unreadable] and IL-18 proteins following K. pneumoniae LPS challenge...
  22. Role of PPAR-gamma in Smoking-induced COPD Progression and Steroid Resistance
    Raju C Reddy; Fiscal Year: 2013
    ..Smoking has been shown to reduce HDAC2 expression and activity in alveolar macrophages, key cells in COPD pathophysiology...
  23. Apoptotic T Cell Clearance From Murine Lungs
    Jeffrey L Curtis; Fiscal Year: 2010
    ..When lung infections are handled successfully, leukocytes die by apoptosis and their clearance by alveolar macrophages (AMO) hastens lung repair via secretion of TGF-beta, PGE2 and IL-10, immunosuppressive mediators that can ..
  24. Role of Ion Channel in Mononuclear Phagocyte Activation
    Deborah J Nelson; Fiscal Year: 2012
    ..Recently, we demonstrated that murine alveolar macrophages (AMs) but not neutrophils employ the CFTR (Cystic Fibrosis Transmembrane conductance Regulator) Cl- channel ..
  25. Targeting copper homeostasis in the fungal pathogen, Cryptococcus neoformans
    RICHARD FESTA; Fiscal Year: 2013
    ..Since alveolar macrophages are the first line of defense against C...
  26. Age-associated Toll-like receptor dysfunction in the lungs
    Carlos J Orihuela; Fiscal Year: 2010
    ..protein levels of TLRs 1-9, and the TLR cell signaling molecules Myd88, IRAK-1, and IRAK-4 are decreased in alveolar macrophages and type II pneumocytes (lung mucosal epithelial cells) isolated from aged versus young and mature mice...
  27. Pneumocystis carinii: Macrophage &Epithelial Activation
    Andrew H Limper; Fiscal Year: 2013
    ..Numerous studies demonstrate that Pneumocystis (Pc) cell wall components including ?-glucans interact with alveolar macrophages and epithelial cells to stimulate the release of cytokines and chemokines that promote inflammatory cell ..
  28. TYPE II SECRETION AND LEGIONELLA PNEUMOPHILA INFECTION
    Nicholas P Cianciotto; Fiscal Year: 2013
    ..During the last grant period, we documented that T2S is required for intracellular infection of amoebae, alveolar macrophages, and lung epithelia as well as bacterial persistence in the lungs of experimentally-infected mice...
  29. Role of GM-CSF in Myeloid Cell Function and Innate Immunity
    Bruce C Trapnell; Fiscal Year: 2013
    ..Pulmonary alveolar proteinosis (PAP) is a syndrome characterized by accumulation of surfactant in alveolar macrophages (AMs) and alveoli resulting in respiratory failure and increased mortality from infection...
  30. The Effects of Fatty Acid Ethyl Esters on the Developing Lung
    SOWMYA S MOHAN; Fiscal Year: 2010
    ..the accumulation of these Fatty Acid Ethyl Esters affects the function of the lung's immune cells, alveolar macrophages, which are the first line of defense against infection in the lung (Aim 2)...
  31. Enhancing neutrophil function in neutropenia-related pneumonia
    Hongbo R Luo; Fiscal Year: 2012
    ..In addition, since alveolar macrophages also play a critical rolein host defense against respiratory tract infections, whether disruption of PTEN ..
  32. Non-oxidative Resistance to A. fumigatus by Alveolar Macrophages
    James B Burritt; Fiscal Year: 2010
    ..b>Alveolar macrophages (AM) are phagocytes known to be important in the early innate defense against A...
  33. Host defense against influenza virus in the lungs of neonatal mice
    Beth A Garvy; Fiscal Year: 2010
    ..epithelial cell production of IL-10 and TGFB and expression of CD200/CD200R on epithelial cells and alveolar macrophages, respectively...
  34. Alveolar Cell Dysfunction and Pulmonary Fibrosis
    Lisa R Young; Fiscal Year: 2011
    ..type II cell-specific transgenesis and murine bone marrow transplantation, to define the contributions of alveolar macrophages and alveolar type II cells to the pulmonary phenotype of the Pearl mouse...
  35. Epigenetic control of asthmatic inflammation by ATF3
    Mark Gilchrist; Fiscal Year: 2010
    ..with ATF3-null mice show overwhelming inflammatory cell influx and overinduction of 8 CC chemokine genes in alveolar macrophages, providing strong evidence that ATF3 plays a critical role in asthma...
  36. Initiation of the Immune Response to Aspergillus fumigatus
    Tobias M Hohl; Fiscal Year: 2013
    ..Beyond resident alveolar macrophages and recruited neutrophils, we identified a rapid influx of chemokine receptor CCR2-expressing monocytes ..
  37. Pathogenesis of Cryptococcus Spores
    Christina M Hull; Fiscal Year: 2013
    ..Using this novel reagent we have discovered that spores can cause disease in a mouse model and that murine alveolar macrophages, the first line of defense against respiratory fungal pathogens, interact fundamentally differently with ..
  38. Cigarette Smoking Alters the Genomic Tone of Alveolar Macrophages
    Martha M Monick; Fiscal Year: 2013
    ..changes in both microRNA expression and methylation status of CpG motifs in the promoter regions in the alveolar macrophages from active smokers compared to "never" smokers...
  39. Recognition of Mtb-Infected Cells by Non-Classically Restritcted CD8+ T Cells
    David M Lewinsohn; Fiscal Year: 2013
    ..Tracheal epithelial cells, type II pneumoncytes, and alveolar macrophages will be prepared, and tested for their ability to process and present Mtb and antigens found within the Mtb ..
  40. Acute Renal Failure Mediated Lung Injury
    Sarah Faubel; Fiscal Year: 2013
    ..production of KC will be assessed by intracellular cytokine staining and flow cytometry of freshly isolated alveolar macrophages and by immunofluorescence...
  41. Pathophysiology of PPARgamma in the lung
    Hong Du; Fiscal Year: 2012
    ..The PPAR( protein is primarily detected in broncho-alveolar macrophages, Clara cells and alveolar type II epithelial cells in the lung...
  42. Identification of novel DNA repair mechanisms in Mycobacterium tuberculosis
    Pallavi Ghosh; Fiscal Year: 2012
    ..This primarily constitutes the respiratory burst that occurs upon phagocytosis of the bacteria by alveolar macrophages and results in the generation of reactive oxygen and nitrogen intermediates...
  43. The Role of Mfge8 and Apoptotic Cell Clearance in Regulating Asthma Severity
    Kamran Atabai; Fiscal Year: 2010
    ..methods including quantification of the number of apoptotic cells on tissue sections, quantification of alveolar macrophages phagocytic capacity, and evaluation of whether the addition of exogenous apoptotic cells regulates the ..
  44. Immunopathology of the Pneumocystis Life Cycle Stages
    Melanie T Cushion; Fiscal Year: 2013
    ..murina cyst and trophic form interactions with alveolar macrophages through a series of binding and phagocytosis assays;and (3) Investigate the role of P...
  45. Air Pollution Particle Effects on Human Antimycobacterial Immunity
    Stephan K Schwander; Fiscal Year: 2013
    ..for major urban combustion pollutants and biomarkers of oxidative stress and (2) particulate matter load of alveolar macrophages and assessments of (3) time activity and (4) geographical indicators will be used to determine in vivo ..
  46. Analysis of the Coxiella burnetii Type IV Secretion System During Infection
    Edward I Shaw; Fiscal Year: 2012
    ..Acquired by inhalation, C. burnetii initially contacts alveolar macrophages and undergoes a bi-phasic life cycle involving structurally distinct forms of the pathogen...
  47. EICOSANOIDS AND LUNG MACROPHAGE ANTIMICROBIAL MECHANISMS
    MARC L PETERS-GOLDEN; Fiscal Year: 2012
    ..b>Alveolar macrophages (AMs) are the resident innate immune defenders of the distal lung, and the immunologic repertoire of these ..
  48. HSCT-induced changes that impair lung innate immunity
    Bethany B Moore; Fiscal Year: 2012
    ..transcription of cyclooxygenase 2 (COX-2) which leads to overproduction of prostaglandin E2 (PGE2) in alveolar macrophages (AMs) and neutrophils (PMNs) and subsequent impaired innate immune function...
  49. REGULATION OF INFLAMMATION BY PULMONARY COLLECTINS
    Peter M Henson; Fiscal Year: 2012
    ..Studies will be performed to address this balance using a variety of potential "danger" signals on resident alveolar macrophages (RAM) in vitro and in the naive mouse lung...
  50. Interactions of smoking, PD-1 and IL-10 in HIV-associated lung disease
    Brent E Palmer; Fiscal Year: 2013
    ..In this regard, smoking and COPD are associated with a re-programming of alveolar macrophages towards an immune phenotype associated with immunoregulation...
  51. Infection with Bordetella pertussis exacerbates Influenza infection
    VICTOR ISAAC AYALA; Fiscal Year: 2010
    ..pertussis infection by targeting alveolar macrophages, altering their production of inflammatory cytokines PT and delaying the recruitment of neutrophils to the ..
  52. Pulmonary innate immunity and pathogens of the order Actinomycetales
    Tracy K Carlson; Fiscal Year: 2012
    ..which have the ability to live in innate immune cells (alveolar macrophages)...
  53. Influence of Macrophage NF-kB Activation on the Outcome of Pneumococcal Pneumonia
    FADIE THOMAS COLEMAN; Fiscal Year: 2013
    ..of understanding the role of specific cell types in the lung during pneumonia, our lab has also shown that alveolar macrophages, which are the first leukocytes to encounter pathogens in the lung, secrete cytokines that are dependent ..
  54. Mast cell dependent inflammatory cascade during influenza A virus infection
    Joshua J Obar; Fiscal Year: 2013
    ..against pathogens in the lungs include alveolar epithelial cells, endothelial cells, tissue resident alveolar macrophages, dendritic cells, and mast cells...
  55. HIGH-DOSE VITAMIN D AND ANTIMICROBIAL PEPTIDE EXPRESSION IN LUNG FAILURE
    Thomas R Ziegler; Fiscal Year: 2012
    ..and hBD-2 mRNA in peripheral blood mononuclear cells (PBMCs), and LL-37 and hBD-2 expression in isolated alveolar macrophages (AM)...
  56. Asbestosis is regulated by Rac1-mediated mitochondrial H2O2 levels
    A Brent Carter; Fiscal Year: 2013
    ..The generation of ROS, particularly H2O2, from alveolar macrophages plays an integral role in the development of pulmonary fibrosis as administration of catalase attenuates ..
  57. Mechanisms of MCP-1 in lung contusion with and without gastric aspiration
    Krishnan Raghavendran; Fiscal Year: 2013
    ..combination, including specific effects of this chemokine in facilitating the recruitment and activation of alveolar macrophages and the subsequent phagocytosis of apoptotic neutrophils. The grant has three Specific Aims...
  58. Pulmonary inflammation and lung cancer development and progression
    Michael Karin; Fiscal Year: 2012
    ..in myeloid cells to determine the contribution of NF-?B-driven inflammatory activation of cells such as alveolar macrophages to lung cancer development and progression...
  59. HIV+ Alveolar Macrophage Oxidant-mediated Apoptosis of Pulmonary Endothelium
    Steven S Gross; Fiscal Year: 2013
    ..approach to explore the hypothesis that the combination of HIV infection and smoking activates alveolar macrophages (AM) to create chronic oxidant stress in the lower respiratory tract that promotes apoptosis of the ..
  60. TRPV4 Initiates Ventilator Induced Lung Injury
    James C Parker; Fiscal Year: 2010
    ..We show (Preliminary Data) that lung epithelial cell monolayers co-cultured with alveolar macrophages activated with trypsin (PAR2), thrombin (PAR1, 3, 4) or the TRPV4 agonist, 4alpha-phoroot 12,13--..
  61. Cigarette Smoke and Autophagy/Lysosomal Pathway Dysfunction
    Martha M Monick; Fiscal Year: 2013
    ..Aim 1 will evaluate the regulation of autophagy/lysosomal pathway by cigarette smoke particulates in human alveolar macrophages. The nature of the particulate matter that builds up in smoker's alveolar macrophages will be ..
  62. Francisella tularensis Interactions with Airway Epithelial Cells
    THOMAS KAWULA; Fiscal Year: 2009
    ..With these models we have found that F. tularensis invades and replicates within tissue and alveolar macrophages, dendritic cells, neutrophils and alveolar type II (AT-II) epithelial cells following inhalation...
  63. TB and Innate Immune Regulation of Lung Macrophages
    Larry S Schlesinger; Fiscal Year: 2013
    ..tb) which survives within alveolar macrophages (AMs)...
  64. Aveolar Macrophage Apoptosis and Pneumocystis
    Chao Hung Lee; Fiscal Year: 2009
    ..The number of alveolar macrophages is decreased in humans with Pneumocystis pneumonia (Pep)...
  65. GM-CSF is required for macrophage surfactant catabolism
    Tracey Bonfield; Fiscal Year: 2006
    ..in the alveoli of surfactant material, which is thought to result from inefficient catabolism by alveolar macrophages and type II epithelial cells...
  66. B DERMATITIDIS CONIDIAL-MACROPHAGE INTERACTIONS
    Stephen Moser; Fiscal Year: 1993
    ..Therefore, a close appraisal of the physiologic role of alveolar macrophages in the primary interaction with Blastomyces dermatitidis conidia is crucial to our understanding of the ..
  67. CHEMOKINES AND HIV REPLICATION IN ALVEOLAR MACROPHAGES
    Michael Coffey; Fiscal Year: 2000
    ..In summary, this proposal will help determine the mechanisms by which HIV replication is regulated by C-C chemokines in AM, and enhance our understanding of and our ability to control HIV infection in the lung. ..
  68. GM-CSF THERAPY FOR ALVEOLAR PROTEINOSIS
    Mary Jane Thomassen; Fiscal Year: 2003
    ..Monocytes and alveolar macrophages from PAP patients produce GM-CSF and respond to GM-CSF, indicating no intrinsic defects in their ability to ..
  69. DETERMINANTS OF LUNG MACROPHAGE ARACHIDONATE METABOLISM
    Marc Peters Golden; Fiscal Year: 1990
    ..Pulmonary alveolar macrophages produce large quantities of arachidonate metabolites in response to a variety of inflammatory stimuli...
  70. Development of Pulmonary Immunocompetency: Focus on the Neonate
    BRETT ALAN SPONSELLER; Fiscal Year: 2010
    ..Lack of production of nitric oxide and peroxynitrite by alveolar macrophages has been documented in fulminant early-onset neonatal pneumonia...
  71. MECHANISMS OF NEUTROPHIL DYSFUNCTION IN BURNS AND TRAUMA
    Joseph Solomkin; Fiscal Year: 1993
    ..b>Alveolar macrophages from patients suffering ARDS secrete a variety of cytokines, including TNF-alpha, IL-1, and neutrophil ..
  72. Innate Immune Response to Coxiella burnetii Infection
    MATTHEW D CALVERLEY; Fiscal Year: 2010
    ..burnetii infection. We have found a subset of long-lived resident alveolar macrophages representing a key site of infection during both later stages of infection and early stages of low dose ..