adipocytes

Summary

Summary: Fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue. Fat is usually stored in the form of TRYGLYCERIDES.

Top Publications

  1. pmc Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    Haiyan Xu
    Millennium Pharmaceuticals, Cambridge, Massachusetts, USA
    J Clin Invest 112:1821-30. 2003
  2. ncbi Multilineage cells from human adipose tissue: implications for cell-based therapies
    P A Zuk
    Laboratory for Regenerative Bioengineering and Repair, UCLA School of Medicine, Los Angeles, California, USA
    Tissue Eng 7:211-28. 2001
  3. ncbi Multilineage potential of adult human mesenchymal stem cells
    M F Pittenger
    Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231 3043, USA
    Science 284:143-7. 1999
  4. pmc Inflammation and insulin resistance
    Steven E Shoelson
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 116:1793-801. 2006
  5. pmc TLR4 links innate immunity and fatty acid-induced insulin resistance
    Hang Shi
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 116:3015-25. 2006
  6. pmc Increased oxidative stress in obesity and its impact on metabolic syndrome
    Shigetada Furukawa
    Department of Medicine and Pathophysiology, Graduate School of Medicine, Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Clin Invest 114:1752-61. 2004
  7. pmc Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
    Jun Wu
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA
    Cell 150:366-76. 2012
  8. pmc Inflammation, stress, and diabetes
    Kathryn E Wellen
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Clin Invest 115:1111-9. 2005
  9. ncbi Adipocyte differentiation from the inside out
    Evan D Rosen
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nat Rev Mol Cell Biol 7:885-96. 2006
  10. pmc Adipose tissue remodeling and obesity
    Kai Sun
    Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8549, USA
    J Clin Invest 121:2094-101. 2011

Detail Information

Publications349 found, 100 shown here

  1. pmc Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    Haiyan Xu
    Millennium Pharmaceuticals, Cambridge, Massachusetts, USA
    J Clin Invest 112:1821-30. 2003
    ..We propose that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue...
  2. ncbi Multilineage cells from human adipose tissue: implications for cell-based therapies
    P A Zuk
    Laboratory for Regenerative Bioengineering and Repair, UCLA School of Medicine, Los Angeles, California, USA
    Tissue Eng 7:211-28. 2001
    ..In conclusion, the data support the hypothesis that a human lipoaspirate contains multipotent cells and may represent an alternative stem cell source to bone marrow-derived MSCs...
  3. ncbi Multilineage potential of adult human mesenchymal stem cells
    M F Pittenger
    Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231 3043, USA
    Science 284:143-7. 1999
    ..These adult stem cells could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages. Individual stem cells were identified that, when expanded to colonies, retained their multilineage potential...
  4. pmc Inflammation and insulin resistance
    Steven E Shoelson
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 116:1793-801. 2006
    ....
  5. pmc TLR4 links innate immunity and fatty acid-induced insulin resistance
    Hang Shi
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 116:3015-25. 2006
    ..nutritional fatty acids, whose circulating levels are often increased in obesity, activate TLR4 signaling in adipocytes and macrophages and that the capacity of fatty acids to induce inflammatory signaling in adipose cells or tissue ..
  6. pmc Increased oxidative stress in obesity and its impact on metabolic syndrome
    Shigetada Furukawa
    Department of Medicine and Pathophysiology, Graduate School of Medicine, Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Clin Invest 114:1752-61. 2004
    ..In cultured adipocytes, elevated levels of fatty acids increased oxidative stress via NADPH oxidase activation, and oxidative stress ..
  7. pmc Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
    Jun Wu
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA
    Cell 150:366-76. 2012
    ..Finally, we provide evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes. These data provide a foundation for studying this mammalian cell type with therapeutic potential. PAPERCLIP:
  8. pmc Inflammation, stress, and diabetes
    Kathryn E Wellen
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Clin Invest 115:1111-9. 2005
    ..We put forth for consideration some hypotheses regarding important unanswered questions in the field and suggest a model for the integration of inflammatory and metabolic pathways in metabolic disease...
  9. ncbi Adipocyte differentiation from the inside out
    Evan D Rosen
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nat Rev Mol Cell Biol 7:885-96. 2006
    ....
  10. pmc Adipose tissue remodeling and obesity
    Kai Sun
    Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8549, USA
    J Clin Invest 121:2094-101. 2011
    ..As such, the tissue requires potent mechanisms to remodel, acutely and chronically. Adipocytes can rapidly reach the diffusional limit of oxygen during growth; hypoxia is therefore an early determinant that ..
  11. ncbi CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    Satoshi Nishimura
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Nat Med 15:914-20. 2009
    ..These results support the notion that CD8(+) T cells have an essential role in the initiation and propagation of adipose inflammation...
  12. ncbi Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
    P Tontonoz
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    Cell 79:1147-56. 1994
    ....
  13. ncbi Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
    Saverio Cinti
    Institute of Normal Human Morphology, University of Ancona, Ancona, Italy
    J Lipid Res 46:2347-55. 2005
    ..We demonstrate that >90% of all macrophages in WAT of obese mice and humans are localized to dead adipocytes, where they fuse to form syncytia that sequester and scavenge the residual "free" adipocyte lipid droplet and ..
  14. ncbi The hormone resistin links obesity to diabetes
    C M Steppan
    Department of Medicine, The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Nature 409:307-12. 2001
    ..Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin)...
  15. pmc Adipocytes as regulators of energy balance and glucose homeostasis
    Evan D Rosen
    Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Centre, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nature 444:847-53. 2006
    b>Adipocytes have been studied with increasing intensity as a result of the emergence of obesity as a serious public health problem and the realization that adipose tissue serves as an integrator of various physiological pathways...
  16. ncbi Forming functional fat: a growing understanding of adipocyte differentiation
    Ana G Cristancho
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, The Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Mol Cell Biol 12:722-34. 2011
    Adipose tissue, which is primarily composed of adipocytes, is crucial for maintaining energy and metabolic homeostasis...
  17. ncbi Adipose tissue, adipokines, and inflammation
    Giamila Fantuzzi
    Department of Human Nutrition, University of Illinois at Chicago, USA
    J Allergy Clin Immunol 115:911-9; quiz 920. 2005
    ..Furthermore, cross-talk between lymphocytes and adipocytes can lead to immune regulation...
  18. ncbi Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
    Guenter Haemmerle
    Institute of Molecular Biosciences, University of Graz, Austria
    Science 312:734-7. 2006
    ..These results indicate that ATGL is rate limiting in the catabolism of cellular fat depots and plays an important role in energy homeostasis...
  19. ncbi Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective
    Sam Virtue
    Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Box 289, Level 4, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Biochim Biophys Acta 1801:338-49. 2010
    ..Finally, we will discuss how considering the concept of allostasis may enable a better understanding of how diabetes develops and allow the rational design of new anti diabetic treatments...
  20. ncbi Adipokines: inflammation and the pleiotropic role of white adipose tissue
    Paul Trayhurn
    Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, UK
    Br J Nutr 92:347-55. 2004
    ..the term 'adipokine' be universally adopted to describe a protein that is secreted from (and synthesised by) adipocytes. It is suggested that the term is restricted to proteins secreted from adipocytes, excluding signals released ..
  21. pmc Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
    Kristin M Nieman
    Department of Obstetrics and Gynecology Section of Gynecologic Oncology, Center for Integrative Science, University of Chicago, Chicago, IL, USA
    Nat Med 17:1498-503. 2011
    ..such as ovarian cancer, have a clear predilection for metastasis to the omentum, an organ primarily composed of adipocytes. Currently, it is unclear why tumor cells preferentially home to and proliferate in the omentum, yet omental ..
  22. ncbi Visfatin: a protein secreted by visceral fat that mimics the effects of insulin
    Atsunori Fukuhara
    Department of Medicine and Pathophysiology, Graduate School of Medicine, and Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Science 307:426-30. 2005
    ..Surprisingly, visfatin binds to and activates the insulin receptor. Further study of visfatin's physiological role may lead to new insights into glucose homeostasis and/or new therapies for metabolic disorders such as diabetes...
  23. pmc High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity
    Masayuki Saito
    Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo, Japan
    Diabetes 58:1526-31. 2009
    ..The objective is to examine the prevalence of metabolically active BAT in healthy adult humans and to clarify the effects of cold exposure and adiposity...
  24. ncbi Inhibition of adipogenesis by Wnt signaling
    S E Ross
    Department of Physiology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0622, USA
    Science 289:950-3. 2000
    ..preadipocytes is prevented by overexpression of Axin or dominant-negative TCF4, these cells differentiate into adipocytes. Disruption of Wnt signaling also causes transdifferentiation of myoblasts into adipocytes in vitro, ..
  25. pmc Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes
    Marica Bordicchia
    Metabolic Signaling and Disease Program, Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida 32827, USA
    J Clin Invest 122:1022-36. 2012
    ..mammals to resist body fat accumulation is linked to their ability to expand the number and activity of "brown adipocytes" within white fat depots...
  26. pmc Transcriptional control of brown fat determination by PRDM16
    Patrick Seale
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Cell Metab 6:38-54. 2007
    ..PRDM16 activates brown fat cell identity at least in part by simultaneously activating PGC-1alpha and PGC-1beta through direct protein binding. These data indicate that PRDM16 can control the determination of brown fat fate...
  27. ncbi Fat and beyond: the diverse biology of PPARgamma
    Peter Tontonoz
    Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, University of California Los Angeles, CA 90095, USA
    Annu Rev Biochem 77:289-312. 2008
    ..Here, we review recent advances in our understanding of the diverse biological actions of PPARgamma with an eye toward the expanding therapeutic potential of PPARgamma agonist drugs...
  28. pmc CCAAT/enhancer-binding proteins: structure, function and regulation
    Dipak P Ramji
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, P O Box 911, Cardiff CF10 3US, Wales, U K
    Biochem J 365:561-75. 2002
    ..and differentiation, metabolism, inflammation and numerous other responses, particularly in hepatocytes, adipocytes and haematopoietic cells...
  29. ncbi Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin
    N Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circulation 100:2473-6. 1999
    ..The present study investigated whether adiponectin could modulate endothelial function and relate to coronary disease...
  30. ncbi Dynamics of fat cell turnover in humans
    Kirsty L Spalding
    Department of Cell and Molecular Biology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Nature 453:783-7. 2008
    ..fat mass in adult humans are not fully understood, but increased lipid storage in already developed fat cells (adipocytes) is thought to be most important...
  31. ncbi The many faces of PPARgamma
    Michael Lehrke
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell 123:993-9. 2005
    ....
  32. pmc Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
    Adilson Guilherme
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Rev Mol Cell Biol 9:367-77. 2008
    ..reflect differences in levels of lipid-droplet proteins that promote the sequestration of fatty acids within adipocytes in the form of triglycerides, thereby lowering exposure of skeletal muscle to the inhibitory effects of fatty ..
  33. ncbi Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase
    Robert Zimmermann
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    Science 306:1383-6. 2004
    ..Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals...
  34. ncbi Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis
    Dawn L Brasaemle
    Department of Nutritional Sciences and the Rutgers Center for Lipid Research, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    J Lipid Res 48:2547-59. 2007
    ..In vertebrates, triacylglycerol-rich lipid droplets of adipocytes provide a major energy storage depot for the body, whereas cholesteryl ester-rich droplets of many other cells ..
  35. ncbi Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
    E D Abel
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 409:729-33. 2001
    ..type 2 diabetes is insulin resistance, characterized by decreased glucose transport and metabolism in muscle and adipocytes. The glucose transporter GLUT4 mediates insulin-stimulated glucose uptake in adipocytes and muscle by rapidly ..
  36. pmc Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice
    Shiho Fujisaka
    First Department of Internal Medicine, Graduate School of Medicine and Pharmaceutical Science for Research, Tokyo, Japan
    Diabetes 58:2574-82. 2009
    ..To characterize the phenotypic changes of adipose tissue macrophages (ATMs) under different conditions of insulin sensitivity...
  37. ncbi AdipoQ is a novel adipose-specific gene dysregulated in obesity
    E Hu
    Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 271:10697-703. 1996
    ..Whereas the biological function of this polypeptide is presently unknown, the tissue-specific expression of a putative secreted protein suggests that this factor may function as a novel signaling molecule for adipose tissue...
  38. ncbi Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome
    E Maury
    Endocrinology and Metabolism Unit, University of Louvain, Faculty of Medicine, 1200 Brussels, Belgium
    Mol Cell Endocrinol 314:1-16. 2010
    ..Targeting the changes in the cellular composition of adipose tissue, the underlying molecular mechanisms, and the altered production of adipokines may have therapeutic potential in the management of the metabolic syndrome...
  39. ncbi MicroRNA-143 regulates adipocyte differentiation
    Christine Esau
    Isis Pharmaceuticals, Carlsbad, California 92008, USA
    J Biol Chem 279:52361-5. 2004
    ..antisense oligonucleotides (ASOs) targeting 86 human miRNAs were transfected into cultured human pre-adipocytes, and their ability to modulate adipocyte differentiation was evaluated...
  40. ncbi PPARs and the complex journey to obesity
    Ronald M Evans
    Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Med 10:355-61. 2004
    ..With molecular underpinnings now in place, new pharmacologic approaches to metabolic disease and new questions are emerging...
  41. ncbi T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity
    Huaizhu Wu
    Section of Atherosclerosis and Vascular Medicine, Baylor College of Medicine, 6565 Fannin, Houston, TX 77030, USA
    Circulation 115:1029-38. 2007
    ..T cells also play important roles in chronic inflammatory diseases such as atherosclerosis but have not been well studied in obesity...
  42. ncbi PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein
    N Maeda
    Department of Internal Medicine and Molecular Science (B5, Graduate School of Medicine, Osaka University, Osaka, Japan
    Diabetes 50:2094-9. 2001
    ..In cultured 3T3-L1 adipocytes, TZD derivatives enhanced the mRNA expression and secretion of adiponectin in a dose- and time-dependent manner...
  43. pmc Adaptive thermogenesis in adipocytes: is beige the new brown?
    Jun Wu
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    Genes Dev 27:234-50. 2013
    ..A deeper understanding of the molecular processes involved in the development and function of these cell types may lead to new therapeutics for obesity, diabetes, and other metabolic diseases...
  44. pmc MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity
    Huangming Xie
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Diabetes 58:1050-7. 2009
    ..We investigated the regulation and involvement of microRNAs (miRNAs) in fat cell development and obesity...
  45. pmc Transcriptional control of adipocyte formation
    Stephen R Farmer
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Cell Metab 4:263-73. 2006
    ..two decades in defining transcriptional events controlling the differentiation of mesenchymal stem cells into adipocytes. A complex network of transcription factors and cell-cycle regulators, in concert with specific transcriptional ..
  46. ncbi The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    A H Berg
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Med 7:947-53. 2001
    ..We thus propose that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism...
  47. ncbi Surface protein characterization of human adipose tissue-derived stromal cells
    S Gronthos
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, Bethesda, Maryland, USA
    J Cell Physiol 189:54-63. 2001
    ..The similarities between the phenotypes of human adipose tissue-derived and human bone marrow-derived stromal cells could have broad implications for human tissue engineering...
  48. ncbi Developmental origin of fat: tracking obesity to its source
    Stephane Gesta
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Cell 131:242-56. 2007
    ..In this Review, we consider how the developmental origins of fat contribute to its physiological, cellular, and molecular heterogeneity and explore how these factors may play a role in the growing epidemic of obesity...
  49. pmc Adipose-derived stem cells: isolation, expansion and differentiation
    Bruce A Bunnell
    Division of Gene Therapy, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA
    Methods 45:115-20. 2008
    ..While this article has focused on the isolation of ASCs from human adipose tissue, the procedure can be applied to adipose tissues from other species with minimal modifications...
  50. ncbi Adipogenesis: from stem cell to adipocyte
    Qi Qun Tang
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Annu Rev Biochem 81:715-36. 2012
    ..factors that induce conversion of mesenchymal stem cells (MSCs) to preadipocytes that differentiate into adipocytes. MSCs, which are recruited from the vascular stroma of adipose tissue, provide an unlimited supply of adipocyte ..
  51. pmc Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes
    Yu Chen
    Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    J Cell Biol 198:545-60. 2012
    ..Thus, multiple Rab proteins regulate the trafficking of GLUT4, with Rab10 coordinating with myosin-Va to mediate the final steps of insulin-stimulated GSV translocation to the PM...
  52. pmc Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis
    Ronni Nielsen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark
    Genes Dev 22:2953-67. 2008
    ..We identify >5000 high-confidence shared PPARgamma:RXR-binding sites in adipocytes and show that during early stages of differentiation, many of these are preoccupied by non-PPARgamma RXR-..
  53. ncbi Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids
    Hongfei Ge
    Amgen Inc, 1120 Veterans Boulevard, South San Francisco, California 94080, USA
    Endocrinology 149:4519-26. 2008
    ..GPR43 is also expressed in a number of other tissues including adipocytes; however, the functional consequences of GPR43 activation in these other tissues are not clear...
  54. ncbi A transgenic model of visceral obesity and the metabolic syndrome
    H Masuzaki
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA
    Science 294:2166-70. 2001
    ..Increased adipocyte 11beta HSD-1 activity may be a common molecular etiology for visceral obesity and the metabolic syndrome...
  55. pmc Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity
    Kihwa Kang
    Department of Genetics and Complex Diseases, Division of Biological Sciences, Harvard School of Public Health, Boston, MA 02115, USA
    Cell Metab 7:485-95. 2008
    ..However, the mechanisms controlling tissue macrophage activation remain unclear. Here we show that adipocytes are a source of Th2 cytokines, including IL-13 and to a lesser extent IL-4, which induce macrophage PPARdelta/..
  56. pmc Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis
    L Makowski
    Division of Biological Sciences and Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Med 7:699-705. 2001
    ..Apoe-/- mice with Ap2+/+ adipocytes and Ap2-/- macrophages generated by bone-marrow transplantation showed a comparable reduction in atherosclerotic ..
  57. ncbi Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes
    Dawn L Brasaemle
    Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA
    J Biol Chem 279:46835-42. 2004
    b>Adipocytes hold the body's major energy reserve as triacylglycerols packaged in large lipid droplets...
  58. pmc Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling
    Eric Festa
    Department of Molecular Biology, Yale University, 219 Prospect St, New Haven, CT 06520, USA
    Cell 146:761-71. 2011
    ..These data highlight adipogenic cells as skin niche cells that positively regulate skin stem cell activity, and suggest that adipocyte lineage cells may alter epithelial stem cell function clinically...
  59. pmc Mitochondrial complex III ROS regulate adipocyte differentiation
    Kathryn V Tormos
    Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    Cell Metab 14:537-44. 2011
    ..Here, we report that primary human mesenchymal stem cells undergoing differentiation into adipocytes display an early increase in mitochondrial metabolism, biogenesis, and reactive oxygen species (ROS) generation...
  60. pmc Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones
    Paul A Dutchak
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Cell 148:556-67. 2012
    ..Adding back FGF21 prevents sumoylation and restores PPARγ activity. Collectively, these results reveal FGF21 as a key mediator of the physiologic and pharmacologic actions of PPARγ...
  61. ncbi A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha
    Takayoshi Suganami
    Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101 0062, Japan
    Arterioscler Thromb Vasc Biol 25:2062-8. 2005
    ..Here we developed an in vitro coculture system composed of adipocytes and macrophages and examined the molecular mechanism whereby these cells communicate.
  62. pmc Monocyte chemoattractant protein 1 in obesity and insulin resistance
    Peter Sartipy
    Department of Cell Biology, Division of Vascular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, VB 3, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:7265-70. 2003
    ..insulin induces substantial expression and secretion of MCP-1 both in vitro in insulin-resistant (IR) 3T3-L1 adipocytes and in vivo in IR obese mice (ob/ob). Thus, MCP-1 resembles other previously described genes (e.g...
  63. pmc Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI
    Tayeba Khan
    Department of Cell Biology, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 29:1575-91. 2009
    b>Adipocytes are embedded in a unique extracellular matrix whose main function is to provide mechanical support, in addition to participating in a variety of signaling events...
  64. pmc A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
    Mark A Herman
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 484:333-8. 2012
    ..ChREBP-β expression in human adipose tissue predicts insulin sensitivity, indicating that it may be an effective target for treating diabetes...
  65. ncbi Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages
    Takayoshi Suganami
    Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Arterioscler Thromb Vasc Biol 27:84-91. 2007
    ..Using an in vitro coculture system composed of 3T3-L1 adipocytes and RAW264 macrophages, we previously demonstrated that saturated fatty acids (FAs) and tumor necrosis factor (..
  66. pmc Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes
    Séverine Kirchner
    Department of Developmental and Cell Biology, 2011 Biological Sciences 3, University of California, Irvine, California 92697 2300, USA
    Mol Endocrinol 24:526-39. 2010
    ..Hence, TBT alters the stem cell compartment by sensitizing multipotent stromal stem cells to differentiate into adipocytes, an effect that could likely increase adipose mass over time.
  67. pmc C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway
    Evan D Rosen
    Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Genes Dev 16:22-6. 2002
    ..These results indicate that C/EBPalpha and PPARgamma participate in a single pathway of fat cell development with PPARgamma being the proximal effector of adipogenesis...
  68. pmc Comparative epigenomic analysis of murine and human adipogenesis
    Tarjei S Mikkelsen
    Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA
    Cell 143:156-69. 2010
    ..We also utilize the close relationship between open chromatin marks and transcription factor motifs to identify and validate PLZF and SRF as regulators of adipogenesis...
  69. ncbi Mesenchymal stem cells can be differentiated into endothelial cells in vitro
    Joachim Oswald
    Institute of Polymer Research Dresden and The Max Bergmann Center of Biomaterials Dresden, Dresden, Germany
    Stem Cells 22:377-84. 2004
    ..cells (MSCs) have the potential to differentiate into mesenchymal tissues like osteocytes, chondrocytes, and adipocytes in vivo and in vitro...
  70. ncbi New developments in adipogenesis
    Martina I Lefterova
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Trends Endocrinol Metab 20:107-14. 2009
    The obesity epidemic has focused attention on adipose tissue and the development of fat cells (i.e. adipocytes), which is known as adipogenesis...
  71. ncbi Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells
    Karin Stenderup
    University Department of Endocrinology and Metabolism, University Hospital of Aarhus, DK 8000 Aarhus C, Denmark
    Bone 33:919-26. 2003
    ..In adipogenic medium similar numbers of adipocytes formed in cultures of young and old donors...
  72. ncbi Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice
    Nicholas M Morton
    Endocrinology Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Diabetes 53:931-8. 2004
    ..Isolated 11 beta-HSD-1(-/-) adipocytes exhibited higher basal and insulin-stimulated glucose uptake...
  73. ncbi The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance
    Gijs H Goossens
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Physiol Behav 94:206-18. 2008
    ..Adipose tissue is now recognized as a highly active metabolic and endocrine organ. Adipocytes are of importance in buffering the daily influx of dietary fat and exert autocrine, paracrine and/or endocrine ..
  74. ncbi Adipose development: from stem cell to adipocyte
    Tamara C Otto
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Crit Rev Biochem Mol Biol 40:229-42. 2005
    Cell culture models have been developed to study commitment and subsequent differentiation of preadipocytes into adipocytes. Bone morphogenetic protein 4 commits mesenchymal stem cells to the adipose lineage...
  75. ncbi Obesity affects the liver - the link between adipocytes and hepatocytes
    Alexander Wree
    Department of Gastroenterology and Hepatology, University of Duisburg Essen, University Clinic Essen, Essen, Germany
    Digestion 83:124-33. 2011
    ..This review summarizes current knowledge - highlighting the inflammatory and cytokine view - of the intimate relationship between adipose and liver tissue...
  76. ncbi Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids
    Mohamed S Zaibi
    Clore Laboratory, University of Buckingham, Buckingham, UK
    FEBS Lett 584:2381-6. 2010
    ..deaminase to minimise Galpha(i) signalling via the adenosine A1 receptor, SCFA stimulated leptin secretion by adipocytes from wild-type but not GPR41 knockout mice. Expression of GPR43 was reduced in GPR41 knockout mice...
  77. pmc Cell-specific determinants of peroxisome proliferator-activated receptor gamma function in adipocytes and macrophages
    Martina I Lefterova
    University of Pennsylvania School of Medicine, 700 CRB, 415 Curie Blvd, Philadelphia, PA 19104 6149, USA
    Mol Cell Biol 30:2078-89. 2010
    ..is whether PPARgamma binding in macrophages occurs at genomic locations the same as or different from those in adipocytes. Here, utilizing chromatin immunoprecipitation and high-throughput sequencing (ChIP-seq), we demonstrate that ..
  78. ncbi Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects
    Victoria Rotter
    Department of Internal Medicine, Lundberg Laboratory for Diabetes Research, The Sahlgrenska Academy, Goteborg University, SE 413 45 Goteborg, Sweden
    J Biol Chem 278:45777-84. 2003
    ..To examine putative mechanisms and cross-talk with insulin, 3T3-L1 adipocytes were cultured for different times with IL-6 and tumor necrosis factor alpha (TNF-alpha)...
  79. pmc Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis
    Violeta Arsenescu
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA
    Environ Health Perspect 116:761-8. 2008
    ..However, the effects of PCBs on adipocytes, obesity, and obesity-associated cardiovascular disease are unknown.
  80. ncbi Cellular hypoxia and adipose tissue dysfunction in obesity
    I Stuart Wood
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
    Proc Nutr Soc 68:370-7. 2009
    ..Studies in animal models (mutant mice, diet-induced obesity) and cell-culture systems (mouse and human adipocytes) have provided strong support for a role for hypoxia in modulating the production of several inflammation-..
  81. pmc Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis
    Naim Alkhouri
    Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 285:3428-38. 2010
    ..Inhibition of adipocyte apoptosis may be a new therapeutic strategy for the treatment of obesity-associated metabolic complications...
  82. ncbi Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein
    J E Schaffer
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Cell 79:427-36. 1994
    ..We used an expression cloning strategy and a cDNA library from 3T3-L1 adipocytes to identify a cDNA that, when expressed in cultured cells, augments uptake of LCFAs...
  83. pmc Adipocyte turnover: relevance to human adipose tissue morphology
    Erik Arner
    Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
    Diabetes 59:105-9. 2010
    Adipose tissue may contain few large adipocytes (hypertrophy) or many small adipocytes (hyperplasia). We investigated factors of putative importance for adipose tissue morphology.
  84. ncbi Adipose tissue: from lipid storage compartment to endocrine organ
    Philipp E Scherer
    Department of Cell Biology, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Diabetes 55:1537-45. 2006
    ..While storage and release of lipids are major functions of adipocytes, the adipocyte also uses specific lipid molecules for intracellular signaling and uses a host of protein factors ..
  85. ncbi Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: cross talk with the osteoblastogenic program
    S Muruganandan
    Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada
    Cell Mol Life Sci 66:236-53. 2009
    Bone marrow mesenchymal stem cells (MSCs) are multipotent cells, which among other cell lineages, give rise to adipocytes and osteoblasts...
  86. ncbi Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation
    M Wabitsch
    Department of Pediatrics, University of Ulm, Ulm, Germany
    Int J Obes Relat Metab Disord 25:8-15. 2001
    ..To develop and to characterize a human preadipocyte cell strain with high capacity for adipose differentiation serving as a model for studying human adipocyte development and metabolism in vitro...
  87. pmc MiRNA expression profile of human subcutaneous adipose and during adipocyte differentiation
    Francisco J Ortega
    Service of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, CIBEROBN CB06 03 0010, Girona, Spain
    PLoS ONE 5:e9022. 2010
    ..the aim of this study was to investigate whether miRNA pattern in human fat cells and subcutaneous adipose tissue is associated to obesity and co-morbidities and whether miRNA expression profile in adipocytes is linked to adipogenesis.
  88. pmc Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity
    Viviane Zorzanelli Rocha
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA, 02115, USA
    Circ Res 103:467-76. 2008
    ..These results indicate a role for T cells and IFNgamma, a prototypical T-helper 1 cytokine, in regulation of the inflammatory response that accompanies obesity...
  89. pmc Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells
    Rana K Gupta
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 15:230-9. 2012
    ..Zfp423(GFP) mice represent a simple tool for the specific localization and isolation of molecularly defined preadipocytes from distinct adipose tissue depots...
  90. ncbi SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes
    Tong Shi
    United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 280:13560-7. 2005
    ..Enforced expression of SIRT3 in the HIB1B brown adipocytes enhances the expression of the uncoupling protein PGC-1alpha, UCP1, and a series of mitochondria-related genes...
  91. ncbi Marrow stromal cells as stem cells for nonhematopoietic tissues
    D J Prockop
    Center for Gene Therapy, Allegheny University of the Health Sciences, MCP Hahnemann School of Medicine, 245 North 15 Street, Mail Stop 421, Philadelphia, PA 19102, USA
    Science 276:71-4. 1997
    ..roughly be defined as mesenchymal, because they can be differentiated in culture into osteoblasts, chondrocytes, adipocytes, and even myoblasts...
  92. ncbi Mechanisms of disease: is osteoporosis the obesity of bone?
    Clifford J Rosen
    The Jackson Laboratory in Bar Harbor, ME 04401, USA
    Nat Clin Pract Rheumatol 2:35-43. 2006
    ..With aging, the composition of bone marrow shifts to favor the presence of adipocytes, osteoclast activity increases, and osteoblast function declines, resulting in osteoporosis...
  93. pmc Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment
    Olaia Naveiras
    Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Massachusetts 02115, USA
    Nature 460:259-63. 2009
    ..Adult bone marrow also contains adipocytes, the number of which correlates inversely with the haematopoietic activity of the marrow...
  94. ncbi Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis
    Josep A Villena
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA
    J Biol Chem 279:47066-75. 2004
    ..In addition, decreased expression of desnutrin in obesity models suggests its possible contribution to the pathophysiology of obesity...
  95. ncbi Human mesenchymal stem cells as an in vitro model for human adipogenesis
    Lenka Janderová
    Pennington Biomedical Research Center 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Obes Res 11:65-74. 2003
    ..new in vitro model for the study of human adipogenesis, to develop the optimal protocol for the differentiation of hMSCs into adipocytes, and to describe effect of mitogen-activated protein kinase on hMSC differentiation into adipocytes.
  96. ncbi Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?
    Paul Trayhurn
    Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, University Clinical Department, Duncan Building, Liverpool L69 3GA, UK
    Br J Nutr 100:227-35. 2008
    ..Wood, Br J Nutr 92, 347-355) that inflammation in adipose tissue in obesity is a response to hypoxia in enlarged adipocytes distant from the vasculature...
  97. ncbi Chromium activates glucose transporter 4 trafficking and enhances insulin-stimulated glucose transport in 3T3-L1 adipocytes via a cholesterol-dependent mechanism
    Guoli Chen
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Center for Diabetes Research, Indianapolis, Indiana 46202, USA
    Mol Endocrinol 20:857-70. 2006
    ..or picolinate (CrPic) salt forms mobilize the glucose transporter, GLUT4, to the plasma membrane in 3T3-L1 adipocytes. Concomitant with an increase in GLUT4 at the plasma membrane, insulin-stimulated glucose transport was enhanced ..
  98. ncbi Role of microRNAs in obesity and the metabolic syndrome
    H M Heneghan
    Department of Surgery, National University of Ireland, Galway, Ireland
    Obes Rev 11:354-61. 2010
    ..This review discusses the role of miRNAs in obesity and related components of the metabolic syndrome, and highlights the potential of using miRNAs as novel biomarkers and therapeutic targets for these diseases...
  99. pmc Mapping of R-SNARE function at distinct intracellular GLUT4 trafficking steps in adipocytes
    Dumaine Williams
    Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, USA
    J Cell Biol 180:375-87. 2008
    ....
  100. ncbi Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes
    Kazuhisa Maeda
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cell Metab 1:107-19. 2005
    ....
  101. ncbi Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice
    I Murano
    Institute of Normal Human Morphology, University of Ancona Politecnica delle Marche, Ancona, Italy
    J Lipid Res 49:1562-8. 2008
    ..that >90% of macrophages infiltrating the adipose tissue of obese animals and humans are arranged around dead adipocytes, forming characteristic crown-like structures (CLS)...

Research Grants70

  1. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
    Aim 1: We test the hypothesis that PRDM16 can drive the formation of functional brown adipocytes in white fat depots of mice to raise energy expenditure and protect against obesity and cold exposure. Diet-Induced Obesity (DIP)...
  2. Iron, Metabolic Regulation and Type 2 Diabetes Risk
    Donald A McClain; Fiscal Year: 2013
    ..The effects of glucose on hepcidin, and subsequent effects on inflammatory signaling in macrophages and adipocytes, will be examined in mouse models with normal glucose tolerance, hyperphagia, diabetes, and with genetic ..
  3. Mitochondrial Dysfunction and Adipose Insulin Resistance
    David A Bernlohr; Fiscal Year: 2013
    ..These studies in sum lead to our central hypothesis: decreased expression of GSTA4 in adipocytes leads to increased carbonylation of multiple protein targets...
  4. Osteocalcin and Metabolic Risk Factors. The Framingham Study
    Yi Hsiang Hsu; Fiscal Year: 2011
    ..However, the underlying mechanisms for how OC interacting with adipocytes, pancreatic 2 cells and other molecules functionally involved in glucose homeostasis are still unclear...
  5. Lipid Droplet Metabolism
    Fredric B Kraemer; Fiscal Year: 2013
    ..of LDs within normal adipocytes and within adipocytes in which specific LD-associated proteins have been manipulated by gene targeting...
  6. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2010
    ..To achieve this goal, we first explore the impact of PM2.5 exposure on white and brown adipocytes and associated vascular dysfunction in transgenic mice expressing yellow fluorescent protein (YFP) under the ..
  7. Lipid Binding Proteins in Obesity and Diabetes Syndromes
    David A Bernlohr; Fiscal Year: 2013
    ..acid binding proteins (FABPS) are intracellular free fatty acid receptors found expressed at high levels in adipocytes and macrophages...
  8. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank A Anania; Fiscal Year: 2010
    ..These peptides have pleotropic effects including stimulating growth of b cells of the pancreas and action on adipocytes. To date there is limited data about a direct role of GLP-1 in hepatocytes...
  9. Mitochondrial Dysfunction and Adipose Insulin Resistance
    DAVID BERNLOHR; Fiscal Year: 2009
    ..These studies in sum lead to our central hypothesis: decreased expression of GSTA4 in adipocytes leads to increased mitochondrial protein carbonylation...
  10. The Somatotropic Axis and Health Aging: A Search for Mechanisms
    Andrzej Bartke; Fiscal Year: 2013
    ..Project 3 will study mechanisms of stress resistance in fibroblasts and pre-adipocytes and evaluate longevity and age-sensitive traits in novel mutant mice developed in Project 2...
  11. Atypical PKC Knockout Models: Effect on Glucose and Lipid Homeostasis
    Robert V Farese; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Insulin stimulates glucose transport in muscle and adipocytes, and lipid synthesis in liver by activating atypical protein kinase C (aPKC) and Akt (PKB)...
  12. Chronic stress mediates fat-related changes in insulin signaling and gut motility
    CHARALABOS contact POTHOULAKIS; Fiscal Year: 2010
    ..we have demonstrated the ability of these neuropeptides not only to induce pro-inflammatory signaling in adipocytes, but also to affect their response to insulin...
  13. Prolactin as a Growth Factor in Breast Cancer
    Nira Ben-Jonathan; Fiscal Year: 2013
    ..The human breast receives PRL input from two sources: the pituitary and local. Within the breast, stromal adipocytes produce significantly more PRL than epithelial cells, and both are under tonic inhibition...
  14. The Role of Adipocyte-Induced Inflammation in Prostate Tumor Progression
    AIMALIE LYNNETTE HARDAWAY; Fiscal Year: 2012
    ..growth and aggressiveness of metastatic prostate cancer in the bone is driven by the CTSK-expressing bone marrow adipocytes and the adipocyte- driven inflammation involving CXCL1 and CXCL2 chemokines...
  15. Role of Membrane Modifications in the Bioactivities of Conjugated Linoleic Acids
    Papasani V Subbaiah; Fiscal Year: 2013
    ..will first determine the incorporation profiles of different CLA isomers into membranes of cultured hepatocytes, adipocytes, and myocytes of human and mouse origins...
  16. Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
    Catherine M Gordon; Fiscal Year: 2013
    ..hormonal abnormalities in girls with AN influence mesenchymal stem cells to differentiate preferentially into adipocytes over osteoblasts...
  17. Lipid Binding Proteins in Obesity and Diabetes Syndromes
    David A Bernlohr; Fiscal Year: 2011
    Fatty acid binding proteins (FABPS) are intracellular free fatty acid receptors found expressed at high levels in adipocytes and macrophages...
  18. Misty: a model for central regulation of bone remodeling
    CLIFFORD JAMES ROSEN; Fiscal Year: 2013
    ..In WAT depots, Misty had brown-like adipocytes suggesting that the SNS is compensating for loss of BAT but that the SNS drive may also be causing age-related ..
  19. Hematopoietic Stem Cell Transplantation in Osteogenesis Imperfecta
    Meenal Mehrotra; Fiscal Year: 2012
    ..cells like mast cells and osteoclasts, while MSCs generate a number of mesenchymal cells including fibroblasts, adipocytes, chondrocytes and osteoblasts...
  20. Novel pathways for fat burning that protects from high fat diet-induced metabolic
    Sihem Boudina; Fiscal Year: 2013
    ..To address this, we generated mice with increased superoxide production in adipocytes through deletion of manganese superoxide dismutase (MnSOD), the sole enzyme responsible for detoxifying ..
  21. Use of umbilical cord as a unique stem cell source for tissue regeneration
    Xiao Dong Chen; Fiscal Year: 2013
    ..layers in vitro under conditions known to induce commitment to a specific cell lineage, including osteoblasts, adipocytes, chondroblasts and cardiomyocytes (mesoderm), nerve (ectoderm) and hepatocytes (endoderm)...
  22. Adipose Tissue Macrophage Phenotype and Function
    Anthony W Ferrante; Fiscal Year: 2013
    ..tissue development, metabolism and endocrine function are essential for the efficient storage of lipids in adipocytes and for normal systemic metabolism...
  23. The Role of H6PDH and 11beta-HSD1 in Type 2 Diabetes and Obesity
    Yanjun Liu; Fiscal Year: 2013
    ..to regulation of 12-HSD1 amplifying GC regeneration by using siRNA technology in intact mouse hepatocytes and adipocytes. These cell culture studies will be reinforced by treatment of animals with specific H6PDH or G6PT siRNA in a ..
  24. Maternal Obesity affects AMP-Kinase in Muscle Cell Differentiation
    Min Du; Fiscal Year: 2013
    ..Myocytes, adipocytes and fibroblasts in fetal SM are derived from mesenchymal stem cells (MSC)...
  25. Repression of PPARgamma-2 by Glucocorticoid-Induced Leucine Zipper
    Xing Ming Shi; Fiscal Year: 2012
    ..osteogenic differentiation of bone marrow progenitor cells, the common precursors of fat- and bone-forming adipocytes and osteoblasts...
  26. Inflammatory hyperalgesia due to TRPV1, the pepper spray receptor in the cornea
    Sharona E Gordon; Fiscal Year: 2013
    ..One of the best-studied examples, trafficking of the Glut4 glucose transporter to the plasma membrane of adipocytes and muscle cells in response to insulin, has revealed a number of important players on which we based our model ..
  27. Endoplasmic Reticulum Chaperone as a Regulator of Obesity and Diabetes
    Amy S Lee; Fiscal Year: 2010
    ..upregulated in adipose tissue of HFD-fed Grp78 mice in adipocyte metabolic function, utilizing primary adipocytes and MEFs from the Grp78 and mice, as well as the 3T3-L1 adipocyte culture system...
  28. The New England Family Study: Fifty Year Post-Perinatal Follow-Up for Life Course
    ERIC contact LOUCKS; Fiscal Year: 2010
    ..Specific analytic objectives include: (a) to investigate if DNA methylation in subcutaneous adipocytes is associated with measures of adiposity derived from DEXA scans, CT lumbar region scans (to assess visceral fat)..
  29. Effect of exposure to organochlorine compounds on the development of obesity and
    GEORGE E HOWELL; Fiscal Year: 2011
    ..that exposure to DDE decreases adipogenesis while increasing the release of leptin and interleukin-6 from adipocytes. Thus, the effect of DDE and oxychlordane exposure on expression and function of adipogenic genes will be ..
  30. Phospholipid-Mediated Metabolic Control in Liver and Brown Adipose Tissue
    David E Cohen; Fiscal Year: 2013
    ..Aim 2 will utilize indirect calorimetry, as well as cultured primary brown adipocytes in order to assess whether PC-TP-Them2 interactions limit mitochondrial fatty acid oxidation...
  31. In vitro Type Two Diabetes Mellitus Tissue Model to Investigate Insulin Resistanc
    KELLY ANNE BURKE; Fiscal Year: 2013
    ..Aim 1 will investigate 2D and 3D co-cultures of human adipocytes with endothelial cells to establish baseline differences in structure and function of the co- cultures in the ..
  32. Inhibition of S14 by Conjugated Linoleic Acid in Advanced Solid Tumor Patients
    Raymond P Perez; Fiscal Year: 2010
    ..we will test the hypothesis that tolerable doses of CLA inhibit expression of S14 mRNA in normal human adipocytes and in tumor biopsies from patients with advanced solid tumors...
  33. Interaction of fetal growth and bisphenol A in obesity
    Frederick S vom Saal; Fiscal Year: 2013
    ..elevated insulin as well as an increase in total abdominal fat weight, but have markedly fewer gonadal fat pad adipocytes and markedly different gene expression profiles relative to equally obese macrosomic mice...
  34. Group X sPLA2: Regulator of lipolysis and glucose homeostasis
    Nancy R Webb; Fiscal Year: 2013
    ..This will be achieved by a) determining whether GX sPLA2 alters the rate of TAG synthesis or hydrolysis in adipocytes;and b) determining whether GX sPLA2 promotes TAG mobilization by activating hormone sensitive lipase...
  35. Novel Small Molecule Therapeutics to Treat Obesity
    SUSAN MEDGHALCHI; Fiscal Year: 2010
    ..inhibit GPAT activity in mitochondrial preparations, (b) preferentially inhibit triglyceride synthesis in 3T3-L1 adipocytes, (c) reversibly reduce weight and food intake in chronic treatment of DIO mice without toxicity, (d) increase ..
  36. Depression, Adipocytokines and Metabolic Dysregulation in Black and White Women
    Susan A Everson Rose; Fiscal Year: 2010
    ..is systematic study of the association between depression and adipocytokines, secretory proteins released from adipocytes that play a critical role in the inflammatory process and are identified as highly significant in atherogenesis ..
  37. Lipocalin 2 in Inflammation and Metabolic Control
    Xiaoli Chen; Fiscal Year: 2012
    ..and antagonize TNF( effects on glucose metabolism, PPAR( gene expression and insulin resistance in 3T3- L1 adipocytes. Moreover, LCN2 suppresses TNF(- and LPS-induced cytokine/chemokine production in adipocytes as well as ..
  38. Sympathetic Regulation of AMPK in the control of non-shivering thermogenesis
    Jacob D Mulligan; Fiscal Year: 2012
    ..patients and age/sex matched controls, the hypothesis that desensitization of adrenergic signaling in white adipocytes is associated with a downregulation of 11 AMPK activity will be tested...
  39. Humoral factors in gender differences in blood pressure control
    Jane F Reckelhoff; Fiscal Year: 2013
    ..HAF rats have increased plasma leptin, a cytokine released from adipocytes, that contributes to SNS activation and increases BP by stimulating brain pro-opiomelanocortin pathway via ..
  40. INSULIN ACTION IN MUSCLE AND FAT CELLS
    JAMES CARLTON GARRISON; Fiscal Year: 2010
    ..Lentivirus will be used to overexpress rictor or to express shRNA to knockdown rictor in 3T3-L1 adipocytes. To investigate mTORC2 function in vivo, we propose to knockout rictor in adipocytes and skeletal muscle of mice. ..
  41. Adipocyte Renin-Angiotensin System and Programming of Hypertension
    Mina Desai; Fiscal Year: 2010
    ..When allowed catch-up growth during the nursing period, the MFR offspring develop hypertrophic adipocytes in concert with increased adipose gene expression of AGT, AT2 and renin...
  42. Translating human PPARy binding regions to gene regulation and metabolic disease
    RAYMOND EDWARD SOCCIO; Fiscal Year: 2013
    ..sequencing (ChIP-Seq) to identify the genome-wide binding sites, or cistrome, for PPAR in cultured human adipocytes. We found tens of thousands of binding sites, showing the power of cistromics to yield enormous amounts of ..
  43. The Forkhead Transcription Factor, FOXO1, and its Role in Pituitary Gland Develop
    BUFFY SUE ELLSWORTH; Fiscal Year: 2010
    ..FOXO1 inhibits proliferation and regulates differentiation and migration of pancreatic 2-cells, myoblasts, adipocytes, and endothelial cells. To test this hypothesis we propose three specific aims: Specific Aim 1...
  44. PHOSPHOPEPTIDE METABOLISM IN ADIPOCYTES
    Joseph Avruch; Fiscal Year: 2013
    ..We will also determine how TOR complex 1 controls the translation of RNAs that bind to the protein IMP2, variants of whose gene appear to confer susceptibility to type 2 diabetes. ..
  45. RISK FACTORS FOR CVD IN WOMEN
    JOANN ELISABETH MANSON; Fiscal Year: 2012
    ..Fatty acid binding protein 4 (FABP4), the lipid binding protein for both adipocytes and macrophages, is an important regulator of lipid and inflammatory cascades...
  46. Post-Developmental Adipocyte Autophagy in Control of Insulin-Glucose Homeostasis
    Timothy E Graham; Fiscal Year: 2013
    ..Such observations led to speculations that inhibiting autophagy in adipocytes might provide a promising strategy for treating or preventing obesity and its metabolic consequences...
  47. FUNCTION AND REGULATION OF OSTEONECTIN IN BONE
    Anne M Delany; Fiscal Year: 2013
    ..Mesenchymal stem cells (MSCs) give rise to both osteoblasts and adipocytes, and MSC lineage allocation is altered in aging...
  48. Roles of Gs Alpha and interaction with Wnt signaling in regulation of adipocyte d
    Partha S Sinha; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Adipocytes and osteoblasts may share a common precursor residing in the bone marrow...
  49. Activation of Atypical PKC by Insulin and Other Agonists
    ROBERT VITO FARESE; Fiscal Year: 2013
    ..a) defined upstream activators of atypical protein kinase C (aPKC) and Akt during insulin action in muscle, adipocytes and liver and (b) showed that aPKC is required for insulin-stimulated increases in glucose transport in muscle ..
  50. The regulation and activation of STATs in adipocytes
    Jacqueline M Stephens; Fiscal Year: 2013
    b>Adipocytes are highly specialized cells that play a major role in energy homeostasis in vertebrates. Obesity is the primary disease of fat cells and the most common metabolic disorder in the industrial world...
  51. Effect of constitutive Type 2 NF-kB on adipogenesis
    LOTUS KYI LOO; Fiscal Year: 2010
    ..found that both LBW242 and SM can inhibit PPAR gamma (master regulator of adipogenesis), C/EBPo and downstream adipocytes specific genes...
  52. Human Cell-Based Models of Primary Adipocyte Disorders
    CHAD ALBERT COWAN; Fiscal Year: 2013
    ..In contrast, mutations in the PLIN1 gene appear to cause a more uniform reduction of adipocytes in all depots...
  53. Seahorse XF96 Extracellular Flux Analyzer
    Enrique Saez; Fiscal Year: 2013
    ..of cells and organisms used to model physiological and pathological processes (including primary hepatocytes, adipocytes, neurons, cardiomyocytes, cancer cells, myotubes, and worms)...
  54. The Regulation of Mitochondrial Function by SIRT3
    Qiang Tong; Fiscal Year: 2010
    ..leading to an up-regulation of the expressions of PPARgamma coactivator PGC-1 alpha and UCP-1 in brown adipocytes or UCP3 in myocytes...
  55. Role of Gsalpha in Regulating Osteoblast Differentiation
    JOY Y WU; Fiscal Year: 2012
    ..Finally, Aim 3 will focus on determining the ability of osteoprogenitors to differentiate towards other mesenchymal lineages such as adipocytes, using lineage tracing in vivo and cell differentiation assays in vitro.
  56. A novel axis regulates adipocyte plasticity
    Sean Hartig; Fiscal Year: 2013
    ..Thus, the ability of adipocytes to store energy as lipids is a crucial component of T2DM, and their production of key metabolic adipokines to ..
  57. Identification and Analysis of Circadian Clock-Controlled Genes
    Jennifer J Loros; Fiscal Year: 2013
    ..In Specific Aim 3, we will use RNA sequencing to determine the circadian profile of clock-controlled genes in adipocytes of wt and RIP140 knockout cells, and will use chromatin immunoprecipitation of RIP140 in adipocytes to begin to ..
  58. Metabolic effects of adipose lipogenesis
    Timothy E McGraw; Fiscal Year: 2013
    ..We will create mice that overexpress or lack ChREBP selectively in adipocytes. Aim 1 is to determine whether increased expression of ChREBP selectively in adipocytes is sufficient to enhance ..
  59. Environmental arsenic and diabetes mellitus
    Miroslav Styblo; Fiscal Year: 2012
    ..are more potent than iAs as inhibitors of insulin signaling and insulin-stimulated glucose uptake in cultured adipocytes. Notably, concentrations of arsenicals that inhibit glucose uptake by adipocytes and arsenic concentrations in ..
  60. Beta-adrenergic regulation of adipose tissue function by PKA and MAP kinases
    Sheila Collins; Fiscal Year: 2009
    ..All 3 known [unreadable]AR subtypes are expressed in adipocytes, and [unreadable]ARs are coupled to increases in intracellular cAMP and activation of cAMP-dependent protein ..
  61. Novel Mechanisms Regulating the Adipocyte-Brain Hepatocyte Axis
    Philipp E Scherer; Fiscal Year: 2013
    ..be collaborating with Phil Scherer on defining the differential transcriptional control of lipogenic pathways in adipocytes and vagal sensory neurons and Jay Horton who will direct the Metabolic Phenotyping Core...
  62. Obesity related pancreatic fat worsens local injury via unsaturated fatty acids
    VIJAY PREM SINGH; Fiscal Year: 2013
    ..To understand this mechanistically, we generated a novel acinar-adipocyte co-culture system. While acini and adipocytes functioned normally in this medium both individually and together in the presence of the lipase inhibitor ..
  63. ADIPOCYTE PROTEIN SECRETION AND INSULIN ACTION
    Harvey Lodish; Fiscal Year: 2007
    In general, the PI will attempt to define multiple endo-/exocytotic compartments in 3T3-L1 adipocytes including vesicles which transport membrane associated proteins like GLUT4, secreted proteins where secretion is stimulated by insulin ..
  64. Imaging evidence: Is there competition between marrow fat and bone?
    Wei Shen; Fiscal Year: 2010
    Osteoporosis is one of the leading health problems in the United States. Recent studies suggest that adipocytes in bone marrow and osteoblasts share the same precursor, mesenchymal stem cells (MSC). Human imaging studies [i.e...
  65. Breast Adipose Participates to Bioactivate Vitamin D and Inhibit Breast Cancer
    Glendon M Zinser; Fiscal Year: 2010
    ..research and cancer prevention, offering a nutritional means of therapy with 25(OH)D3, bioactivated by the adipocytes and localizing therapy to breast tissue...
  66. REGULATION OF LDL RECEPTORS IN ADIPOCYTES
    FREDRIC KRAEMER; Fiscal Year: 1993
    ..much progress has been made in elucidating the pathways regulating cholesterol uptake and storage in most cells, adipocytes have not been well investigated...
  67. Transcription & Function of Adipocyte Beta3AR in Obesity
    Sheila Collins; Fiscal Year: 2006
    ..to potent stimulation of lipolysis, beta3AR agonists promote the appearance of thermogenically active brown adipocytes in typical white adipose depots but the mechanism responsible for this effect is not understood...
  68. TONIC ACTIVITY OF ADENOSINE A1-ADENOSINE RECEPTORS
    John Shryock; Fiscal Year: 2003
    ..in white adipose tissue are tonically active and treatment with antagonists of the A1- adenosine receptors in adipocytes are spontaneously active and cause inhibition of lipolysis even in the absence of an agonist, (2) there is a ..
  69. BETA 3-ADRENOCEPTORS AND MAP KINASE IN ADIPOCYTES
    Sheila Collins; Fiscal Year: 2003
    ..to potent stimulation of lipolysis, beta3AR agonists promote the appearance of thermogenically active brown adipocytes in typical white adipose depots but the mechanism responsible for this effect is not understood...
  70. ADENOSINE RECEPTOR REGULATION AND INSULIN ACTION
    Allan Green; Fiscal Year: 1992
    Endogenous adenosine can markedly potentiate the effects of insulin, in isolated adipocytes. This is thought to be mediated via A1 adenosine receptors, which are coupled to inhibition of adenylate cyclase (and possibly other effector ..