Summary: Specific particles of membrane-bound organized living substances present in eukaryotic cells, such as the MITOCHONDRIA; the GOLGI APPARATUS; ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.

Top Publications

  1. ncbi Global analysis of protein localization in budding yeast
    Won Ki Huh
    Howard Hughes Medical Institute, University of California San Francisco, Department of Biochemistry and Biophysics, 600 16th Street, San Francisco, California 94143 2240, USA
    Nature 425:686-91. 2003
  2. pmc Photoacoustic tomography: in vivo imaging from organelles to organs
    Lihong V Wang
    Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Science 335:1458-62. 2012
  3. pmc Lipid droplets finally get a little R-E-S-P-E-C-T
    Robert V Farese
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Cell 139:855-60. 2009
  4. ncbi Lipid droplets: a unified view of a dynamic organelle
    Sally Martin
    Institute for Molecular Bioscience, and Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, QLD 4072, Australia
    Nat Rev Mol Cell Biol 7:373-8. 2006
  5. pmc Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast
    Weihua Fei
    Department of Biochemistry, National University of Singapore, Singapore 117597, Republic of Singapore
    J Cell Biol 180:473-82. 2008
  6. ncbi Toxoplasma sortilin-like receptor regulates protein transport and is essential for apical secretory organelle biogenesis and host infection
    Pierre Julien Sloves
    Center for Infection and Immunity of Lille, Universite Lille Nord de France, Lille, France
    Cell Host Microbe 11:515-27. 2012
  7. ncbi Proteomic analysis of rhoptry organelles reveals many novel constituents for host-parasite interactions in Toxoplasma gondii
    Peter J Bradley
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 280:34245-58. 2005
  8. pmc NAADP mobilizes calcium from acidic organelles through two-pore channels
    Peter J Calcraft
    Centre for Integrative Physiology, College of Medicine and Veterinary Medicine, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, Scotland, UK
    Nature 459:596-600. 2009
  9. ncbi Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    H Jomaa
    Institute of Biochemistry, Academic Hospital Centre, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Science 285:1573-6. 1999
  10. ncbi Lysosome-related organelles
    E C Dell'Angelica
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 5430, USA
    FASEB J 14:1265-78. 2000

Research Grants

Detail Information

Publications365 found, 100 shown here

  1. ncbi Global analysis of protein localization in budding yeast
    Won Ki Huh
    Howard Hughes Medical Institute, University of California San Francisco, Department of Biochemistry and Biophysics, 600 16th Street, San Francisco, California 94143 2240, USA
    Nature 425:686-91. 2003 the context of transcriptional, genetic, and protein-protein interaction data helps reveal the logic of transcriptional co-regulation, and provides a comprehensive view of interactions within and between organelles in eukaryotic cells.
  2. pmc Photoacoustic tomography: in vivo imaging from organelles to organs
    Lihong V Wang
    Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Science 335:1458-62. 2012
    ..tomography (PAT) can create multiscale multicontrast images of living biological structures ranging from organelles to organs...
  3. pmc Lipid droplets finally get a little R-E-S-P-E-C-T
    Robert V Farese
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Cell 139:855-60. 2009
    Long underappreciated as important cellular organelles, lipid droplets are finally being recognized as dynamic structures with a complex and interesting biology...
  4. ncbi Lipid droplets: a unified view of a dynamic organelle
    Sally Martin
    Institute for Molecular Bioscience, and Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, QLD 4072, Australia
    Nat Rev Mol Cell Biol 7:373-8. 2006
    ..seem to be able to generate lipid droplets, their biogenesis, regulatory mechanisms and interactions with other organelles remain largely elusive...
  5. pmc Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast
    Weihua Fei
    Department of Biochemistry, National University of Singapore, Singapore 117597, Republic of Singapore
    J Cell Biol 180:473-82. 2008
    Lipid droplets (LDs) are emerging cellular organelles that are of crucial importance in cell biology and human diseases...
  6. ncbi Toxoplasma sortilin-like receptor regulates protein transport and is essential for apical secretory organelle biogenesis and host infection
    Pierre Julien Sloves
    Center for Infection and Immunity of Lille, Universite Lille Nord de France, Lille, France
    Cell Host Microbe 11:515-27. 2012
    Apicomplexan parasites have an assortment of unique apical secretory organelles (rhoptries and micronemes), which have crucial functions in host infection...
  7. ncbi Proteomic analysis of rhoptry organelles reveals many novel constituents for host-parasite interactions in Toxoplasma gondii
    Peter J Bradley
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 280:34245-58. 2005
    Rhoptries are specialized secretory organelles that are uniquely present within protozoan parasites of the phylum Apicomplexa...
  8. pmc NAADP mobilizes calcium from acidic organelles through two-pore channels
    Peter J Calcraft
    Centre for Integrative Physiology, College of Medicine and Veterinary Medicine, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, Scotland, UK
    Nature 459:596-600. 2009
    ..Thus, TPCs form NAADP receptors that release Ca(2+) from acidic organelles, which can trigger further Ca(2+) signals via sarcoplasmic/endoplasmic reticulum...
  9. ncbi Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    H Jomaa
    Institute of Biochemistry, Academic Hospital Centre, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Science 285:1573-6. 1999
    ..Both drugs suppressed the in vitro growth of multidrug-resistant P. falciparum strains. After therapy with these drugs, mice infected with the rodent malaria parasite P. vinckei were cured...
  10. ncbi Lysosome-related organelles
    E C Dell'Angelica
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 5430, USA
    FASEB J 14:1265-78. 2000
    Lysosomes are membrane-bound cytoplasmic organelles involved in intracellular protein degradation. They contain an assortment of soluble acid-dependent hydrolases and a set of highly glycosylated integral membrane proteins...
  11. pmc Identification of the moving junction complex of Toxoplasma gondii: a collaboration between distinct secretory organelles
    David L Alexander
    Department of Microbiology and Immunology, Stanford University, Stanford, California, USA
    PLoS Pathog 1:e17. 2005
    ..this process, apical membrane antigen 1 (AMA1) is released onto the parasite surface from specialized secretory organelles called micronemes. The T...
  12. ncbi Nuclearly encoded splicing factors implicated in RNA splicing in higher plant organelles
    Andéol Falcon de Longevialle
    Unité Mixte de Recherche en Génomique Végétale Institut National de la Recherche Agronomique Centre National de la Recherche Scientifique Université d Evry Val d Essonne, 91057 Evry, France
    Mol Plant 3:691-705. 2010
    Plant organelles arose from two independent endosymbiosis events...
  13. ncbi Curvature, lipid packing, and electrostatics of membrane organelles: defining cellular territories in determining specificity
    Joëlle Bigay
    Institut de Pharmacologie Moleculaire et Cellulaire, Université de Nice Sophia Antipolis et CNRS, 06560 Valbonne, France
    Dev Cell 23:886-95. 2012
    Whereas some rare lipids contribute to the identity of cell organelles, we focus on the abundant lipids that form the matrix of organelle membranes...
  14. ncbi XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation
    A L Shaffer
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Immunity 21:81-93. 2004
    ..Thus, XBP1 coordinates diverse changes in cellular structure and function resulting in the characteristic phenotype of professional secretory cells...
  15. pmc Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasites
    Shailja Singh
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    PLoS Pathog 6:e1000746. 2010
    ..Parasite proteins that bind erythrocyte receptors during invasion are localized in apical organelles called micronemes and rhoptries...
  16. ncbi Mechanisms shaping the membranes of cellular organelles
    Yoko Shibata
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Cell Dev Biol 25:329-54. 2009
    Cellular organelles have characteristic morphologies that arise as a result of different local membrane curvatures...
  17. pmc A role for lipid droplets in inter-membrane lipid traffic
    John K Zehmer
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Proteomics 9:914-21. 2009
    ..Recent proteomic analyses indicate that lipid droplets are not simple lipid storage depots, but rather complex organelles that have multiple cellular functions...
  18. pmc Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
    K Stamer
    Max Planck Unit for Structural Molecular Biology, 22607 Hamburg, Germany
    J Cell Biol 156:1051-63. 2002
    We studied the effect of microtubule-associated tau protein on trafficking of vesicles and organelles in primary cortical neurons, retinal ganglion cells, and neuroblastoma cells...
  19. ncbi Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic
    Pingsheng Liu
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    J Biol Chem 279:3787-92. 2004
    ..Based on the protein profile, the lipid droplet appears to be a complex, metabolically active organelle that is directly involved in membrane traffic and possibly phospholipid recycling. We propose the name adiposome for this organelle...
  20. ncbi Lipid droplets as dynamic organelles connecting storage and efflux of lipids
    Sven Olof Olofsson
    Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Biochim Biophys Acta 1791:448-58. 2009
    Neutral lipids are stored in the cytosol in so-called lipid droplets. These are dynamic organelles with neutral lipids as the core surrounded by a monolayer of amphipathic lipids (phospholipids and cholesterol) and specific proteins (PAT ..
  21. ncbi Dynamic activity of lipid droplets: protein phosphorylation and GTP-mediated protein translocation
    Rene Bartz
    Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9039, USA
    J Proteome Res 6:3256-65. 2007
  22. pmc Lipid bodies in inflammatory cells: structure, function, and current imaging techniques
    Rossana C N Melo
    Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora UFJF, Juiz de Fora, MG, Brazil
    J Histochem Cytochem 59:540-56. 2011
    Lipid bodies (LBs), also known as lipid droplets, have increasingly been recognized as functionally active organelles linked to diverse biological functions and human diseases...
  23. ncbi Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast
    Stuart A Ralph
    Institut Pasteur, Biology of Host Parasite Interactions, 25 rue du Docteur Roux, 75724, Paris, Cedex 15, France
    Nat Rev Microbiol 2:203-16. 2004
  24. pmc Lysosome-related organelles: driving post-Golgi compartments into specialisation
    Graca Raposo
    Institut Curie, Centre de Recherche, Paris F 75248, France
    Curr Opin Cell Biol 19:394-401. 2007
    Some cells harbour specialised lysosome-related organelles (LROs) that share features of late endosomes/lysosomes but are functionally, morphologically and/or compositionally distinct...
  25. pmc Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae
    K Athenstaedt
    Institut fur Biochemie und Lebensmittelchemie, Technische Universität and SFB Biomembrane Research Center, Petersgasse 12 2, A 8010 Graz, Austria
    J Bacteriol 181:6441-8. 1999
    ..Strains with YBR177c, YMR313c, and YKL140w deleted exhibited phospholipid and/or neutral lipid patterns that were different from the wild-type strain and thus may be further candidate ORFs involved in yeast lipid metabolism...
  26. ncbi Magnetosomes are cell membrane invaginations organized by the actin-like protein MamK
    Arash Komeili
    Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125, USA
    Science 311:242-5. 2006
    Magnetosomes are membranous bacterial organelles sharing many features of eukaryotic organelles...
  27. pmc Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy
    Sooyeon Lee
    Department of Neuroscience Physiology, New York University Langone Medical Center, New York, New York 10016, USA
    J Neurosci 31:7817-30. 2011
    ..Mitochondria and other organelles lacking cathepsins moved normally under these conditions, indicating that the general functioning of the axonal ..
  28. ncbi Lipid droplets: size matters
    Michitaka Suzuki
    Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Electron Microsc (Tokyo) 60:S101-16. 2011
    ..These differences confer distinct properties on adipocyte and non-adipocyte LDs. In this article, we address the current understanding of LDs by discussing the differences between adipocyte and non-adipocyte LDs...
  29. pmc Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis
    Jane M Carlton
    Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA
    Science 315:207-12. 2007
    ..The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria...
  30. ncbi Proteins under new management: lipid droplets deliver
    Michael A Welte
    Rosenstiel Biomedical Research Center and Department of Biology, 415 South Street, Waltham, MA 02454, USA
    Trends Cell Biol 17:363-9. 2007
    Lipid droplets are ubiquitous organelles that store neutral lipids and have crucial roles in lipid metabolism...
  31. ncbi Proteomics of organelles and large cellular structures
    John R Yates
    Department of Cell Biology, 10550 North Torrey Pines Road, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Rev Mol Cell Biol 6:702-14. 2005
    The mass-spectrometry-based identification of proteins has created opportunities for the study of organelles, transport intermediates and large subcellular structures...
  32. ncbi Nanotubular highways for intercellular organelle transport
    Amin Rustom
    Interdisciplinary Center of Neuroscience IZN, Institute of Neurobiology, University of Heidelberg, INF 364, Heidelberg 69120, Germany
    Science 303:1007-10. 2004
    ..These structures facilitate the selective transfer of membrane vesicles and organelles but seem to impede the flow of small molecules...
  33. ncbi Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic
    Rene Bartz
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9039, USA
    J Lipid Res 48:837-47. 2007
    ..These results suggest that droplets play a central role in ether lipid metabolism and intracellular lipid traffic...
  34. ncbi (+)RNA viruses rewire cellular pathways to build replication organelles
    George A Belov
    Virginia Maryland College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Curr Opin Virol 2:740-7. 2012
    ..of (+)RNA viruses for cellular membranes for genome replication, and the formation of membranous replication organelles with similar architecture, suggest that they target essential control mechanisms of membrane metabolism ..
  35. ncbi Bacterial microcompartments
    Cheryl A Kerfeld
    U S Department of Energy Joint Genome Institute, Walnut Creek, California 94598, USA
    Annu Rev Microbiol 64:391-408. 2010
    Bacterial microcompartments (BMCs) are organelles composed entirely of protein...
  36. pmc Toxoplasma evacuoles: a two-step process of secretion and fusion forms the parasitophorous vacuole
    S Hakansson
    Department of Molecular Microbiology, Washington University School of Medicine, Box 8230, 660 S Euclid Avenue, St Louis, MO 63110, USA
    EMBO J 20:3132-44. 2001
    Rapid discharge of secretory organelles called rhoptries is tightly coupled with host cell entry by the protozoan parasite Toxoplasma gondii...
  37. ncbi Mechanisms of lipid-body formation
    D J Murphy
    Dept of Brassica and Oilseeds Research, John Innes Centre, Norwich Research Park, Norwich, UK NR4 7UH
    Trends Biochem Sci 24:109-15. 1999
  38. ncbi Micellar nanocontainers distribute to defined cytoplasmic organelles
    Radoslav Savic
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, H3G 1Y6, Canada
    Science 300:615-8. 2003
    ..Triple-labeling confocal microscopy in live cells revealed the localization of micelles in several cytoplasmic organelles, including mitochondria, but not in the nucleus...
  39. ncbi Peroxisomes as dynamic organelles: autophagic degradation
    Masahide Oku
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto, Japan
    FEBS J 277:3289-94. 2010
    ..Physiological functions of this process (especially cellular remodeling) in mammalian cells and in a phytopathogenic fungus are also introduced...
  40. pmc Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
    Masaaki Komatsu
    Department of Molecular Oncology, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
    J Cell Biol 169:425-34. 2005
    ..autophagosome formation, amino acid supply in neonates, and starvation-induced bulk degradation of proteins and organelles in mice...
  41. ncbi Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission
    Sara Al Rawi
    Universite Pierre et Marie Curie Paris VI, UMR7622 Biologie du Developpement, 9 Quai St Bernard, Paris, France
    Science 334:1144-7. 2011
    ..reproduction of most animals, the spermatozoon provides DNA and centrioles, together with some cytoplasm and organelles, to the oocyte that is being fertilized...
  42. ncbi Metabolic pathways in the apicoplast of apicomplexa
    Frank Seeber
    Robert Koch Institut, Berlin, Germany
    Int Rev Cell Mol Biol 281:161-228. 2010
    ..Finally, we highlight some aspects that emerged from recent publications and were not discussed previously with regard to Apicomplexa...
  43. ncbi The biogenesis and functions of exosomes
    Willem Stoorvogel
    Department of Cell Biology, Institute of Biomembranes and Centre for Biomedical Genetics, University Medical Center Utrecht, The Netherlands
    Traffic 3:321-30. 2002
    ..Exosomes may have evolved early in the evolution of multicellular organisms and also seem to be important for tissue developmental processes...
  44. ncbi Kiss and spit: the dual roles of Toxoplasma rhoptries
    John C Boothroyd
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305 5124, USA
    Nat Rev Microbiol 6:79-88. 2008
    ..Upon entry, this Apicomplexan parasite co-opts host functions for its own purposes. An unusual set of apical organelles, named rhoptries, contain some of the machinery that is used by T...
  45. ncbi Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 2: changes in spermatid organelles associated with development of spermatozoa
    Louis Hermo
    Faculty of Medicine, Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada H3A 2B2
    Microsc Res Tech 73:279-319. 2010
    ..During spermiogenesis, many genes/proteins have been implicated in the diverse dynamic events occurring at this time of development of germ cells and the absence of some of these have been shown to result in subfertility or infertility...
  46. ncbi Endosymbiotic gene transfer: organelle genomes forge eukaryotic chromosomes
    Jeremy N Timmis
    School of Molecular and Biomedical Science, The University of Adelaide, South Australia 5005, Australia
    Nat Rev Genet 5:123-35. 2004
  47. ncbi Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics
    Erica L Dahl
    Department of Medicine, Division of Infectious Disease, Box 0811, University of California, San Francisco, San Francisco, CA 94143, USA
    Trends Parasitol 24:279-84. 2008
    ..Interestingly, the antibiotics thiostrepton and rifampin are fast acting and might target additional processes outside the apicoplast...
  48. ncbi Radiation response of cell organelles
    Z Somosy
    Fodor Jozsef National Centre of Public Health, National Frédéric Joliot Curie Research Institute for Radiobiology and Radiohygiene, Budapest, Hungary
    Micron 31:165-81. 2000
    ..fields is manifested as irreversible and reversible structural and functional changes to cells and cell organelles. Moreover, beside the morphological signs related to cell death, there are several reversible alterations in the ..
  49. pmc A dynamin is required for the biogenesis of secretory organelles in Toxoplasma gondii
    Manuela S Breinich
    Hygiene Institute, Department of Parasitology, Heidelberg University School of Medicine, Germany
    Curr Biol 19:277-86. 2009
    ..Yet these obligate intracellular parasites evolved a set of unique secretory organelles (micronemes, rhoptries, and dense granules) that are required for invasion and modulation of the host cell...
  50. pmc Lipid droplets as fat storage organelles in Caenorhabditis elegans: Thematic Review Series: Lipid Droplet Synthesis and Metabolism: from Yeast to Man
    Ho Yi Mak
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    J Lipid Res 53:28-33. 2012
    Lipid droplets are evolutionarily conserved organelles where cellular fat storage and mobilization are exquisitely regulated. Recent studies have defined lipid droplets in C...
  51. ncbi The Toxoplasma protein ARO mediates the apical positioning of rhoptry organelles, a prerequisite for host cell invasion
    Christina Mueller
    Department of Microbiology and Molecular Medicine, CMU, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Cell Host Microbe 13:289-301. 2013
    ..actively enter host cells by a process involving the discharge of the apically localized microneme and rhoptry organelles. To unravel the processes involved in rhoptry organelle biogenesis, we focused on the Toxoplasma gondii ..
  52. pmc Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites
    Jingyi Gong
    Peking Tsinghua Center for Life Sciences, Tsinghua University, Beijing 100084, China
    J Cell Biol 195:953-63. 2011
    Lipid droplets (LDs) are dynamic cellular organelles that control many biological processes. However, molecular components determining LD growth are poorly understood...
  53. ncbi Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method
    Christopher J Tonkin
    Plant Cell Biology Research Centre, School of Botany, The University of Melbourne, Parkville, VIC 3010, Australia
    Mol Biochem Parasitol 137:13-21. 2004
    The apicoplast and mitochondrion of the malaria parasite Plasmodium falciparum are important intracellular organelles and targets of several anti-malarial drugs...
  54. pmc Evolution of apicomplexan secretory organelles
    Marc Jan Gubbels
    Department of Biology, Boston College, 140 Commonwealth Avenue, Higgins Hall 355, Chestnut Hill, MA 02467, USA
    Int J Parasitol 42:1071-81. 2012
    ..Here the evolution of apicomplexan secretory organelles that are involved in the critical process of egress from one cell and invasion of another is explored...
  55. pmc Super-resolution fluorescence imaging of organelles in live cells with photoswitchable membrane probes
    Sang Hee Shim
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 109:13978-83. 2012
    Imaging membranes in live cells with nanometer-scale resolution promises to reveal ultrastructural dynamics of organelles that are essential for cellular functions...
  56. ncbi The Trichomonas vaginalis hydrogenosome proteome is highly reduced relative to mitochondria, yet complex compared with mitosomes
    Rachel E Schneider
    Department of Microbiology, Immunology and Molecular Genetics David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Int J Parasitol 41:1421-34. 2011
    ..Trichomonas vaginalis lacks conventional mitochondria and instead contains divergent mitochondrial-related organelles. These double-membrane bound organelles, called hydrogenosomes, produce molecular hydrogen...
  57. pmc Conserving a volatile metabolite: a role for carboxysome-like organelles in Salmonella enterica
    Joseph T Penrod
    Microbiology Section, Division of Biological Sciences, University of California Davis, Davis, CA, USA
    J Bacteriol 188:2865-74. 2006
    ..We propose that carboxysome-like organelles help bacteria conserve certain volatile metabolites-CO(2) or acetaldehyde-perhaps by providing a low-pH ..
  58. pmc The protein shells of bacterial microcompartment organelles
    Todd O Yeates
    UCLA Department of Chemistry and Biochemistry, Los Angeles, CA, USA
    Curr Opin Struct Biol 21:223-31. 2011
    ..structure and function of a remarkable class of capsid-like protein assemblies that serve as simple metabolic organelles in many bacteria...
  59. pmc CK1 activates minus-end-directed transport of membrane organelles along microtubules
    Kazuho Ikeda
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Mol Biol Cell 22:1321-9. 2011
  60. ncbi Dense granules: are they key organelles to help understand the parasitophorous vacuole of all apicomplexa parasites?
    Corinne Mercier
    Institut Jean Roget, Universite Joseph Fourier, CNRS UMR 5163, Place du Commandant Nal, 38700 La Tronche, France
    Int J Parasitol 35:829-49. 2005
    Together with micronemes and rhoptries, dense granules are specialised secretory organelles of Apicomplexa parasites...
  61. ncbi The lipid droplet is an important organelle for hepatitis C virus production
    Yusuke Miyanari
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Nat Cell Biol 9:1089-97. 2007
    ..It dynamically moves through the cytoplasm, interacting with other organelles, including the endoplasmic reticulum (ER)...
  62. ncbi Muscle intermediate filaments and their links to membranes and membranous organelles
    Yassemi Capetanaki
    Cell Biology Division, Center of Basic Research, Biomedical Research Foundation Academy of Athens, Soranou Efessiou 4, 12965 Athens, Greece
    Exp Cell Res 313:2063-76. 2007
    ..Similar links have been established for lysosomes and lysosome-related organelles, consistent with the presence of widespread links between IFs and membranous structures and the regulation of ..
  63. ncbi Interactions between the endoplasmic reticulum, mitochondria, plasma membrane and other subcellular organelles
    Magdalena Lebiedzinska
    Nencki Institute of Experimental Biology, Department of Biochemistry, Warsaw, Poland
    Int J Biochem Cell Biol 41:1805-16. 2009
    ..dynamic contacts between mitochondria, the plasma membrane, the endoplasmic reticulum, and other subcellular organelles. Many cellular processes require proper cooperation between the plasma membrane, the nucleus and subcellular ..
  64. ncbi The mechanisms of vesicle budding and fusion
    Juan S Bonifacino
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 116:153-66. 2004
    ..have produced a detailed picture of the molecular mechanisms involved in selective cargo transport between organelles. This transport occurs by means of vesicular intermediates that bud from a donor compartment and fuse with an ..
  65. pmc Capture and release of partially zipped trans-SNARE complexes on intact organelles
    Matthew L Schwartz
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    J Cell Biol 185:535-49. 2009
    ..we use a set of truncated SNAREs to trap kinetically stable, partially zipped trans-SNARE complexes on intact organelles in the absence of hemifusion and content mixing...
  66. ncbi Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis
    Katherine A Mattos
    Laboratórios de Microbiologia Celular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
    J Leukoc Biol 87:371-84. 2010
  67. ncbi The Drosophila fusome, a germline-specific organelle, contains membrane skeletal proteins and functions in cyst formation
    H Lin
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210, USA
    Development 120:947-56. 1994
    ..Our results imply that Drosophila fusomes are required for ovarian cyst formation and suggest that membrane skeletal proteins regulate cystocyte divisions...
  68. ncbi Pentatricopeptide repeat (PPR) proteins as sequence-specificity factors in post-transcriptional processes in organelles
    E Delannoy
    ARC Centre of Excellence in Plant Energy Biology, University of Western Australia, 35 Stirling Highway, Crawley, Perth 6009, WA, Australia
    Biochem Soc Trans 35:1643-7. 2007
    PPR (pentatricopeptide repeat) genes form a large family particularly prevalent in higher plants and targeted to organelles. They are involved in many post-transcriptional processes such as splicing, editing, processing and translation...
  69. ncbi A hypothesis on the identification of the editing enzyme in plant organelles
    Veronique Salone
    URGV, 2 rue Gaston Cremieux, F 91057 Evry Cedex, France
    FEBS Lett 581:4132-8. 2007
    RNA editing in plant organelles is an enigmatic process leading to conversion of cytidines into uridines. Editing specificity is determined by proteins; both those known so far are pentatricopeptide repeat (PPR) proteins...
  70. pmc Cytoskeletal components of an invasion machine--the apical complex of Toxoplasma gondii
    Ke Hu
    Department of Cell Biology, Scripps Research Institute, La Jolla, California, United States of America
    PLoS Pathog 2:e13. 2006
    ..Surprisingly, the extreme apical and extreme basal structures of this highly polarized cell originate in the same location and at the same time very early during parasite replication...
  71. ncbi Imaging lipid bodies in cells and tissues using third-harmonic generation microscopy
    Delphine Debarre
    Laboratory for Optics and Biosciences, Ecole Polytechnique, CNRS, INSERM, F 91128 Palaiseau, France
    Nat Methods 3:47-53. 2006
  72. pmc Leukocyte lipid bodies - Biogenesis and functions in inflammation
    Patricia T Bozza
    Laboratorio de Imunofarmacologia, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Av Brasil, 4365, Manguinhos, 21045 900, Rio de Janeiro, RJ, Brazil
    Biochim Biophys Acta 1791:540-51. 2009
    ..related to the biogenesis and structure of leukocyte lipid bodies (also known as lipid droplets) as inflammatory organelles. Studies of leukocyte lipid bodies are providing functional, ultrastructural and protein compositional evidences ..
  73. pmc Syntaxin 3 and SNAP-25 pairing, regulated by omega-3 docosahexaenoic acid, controls the delivery of rhodopsin for the biogenesis of cilia-derived sensory organelles, the rod outer segments
    Jana Mazelova
    Department of Surgery, Division of Ophthalmology, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Cell Sci 122:2003-13. 2009
    The biogenesis of cilia-derived sensory organelles, the photoreceptor rod outer segments (ROS), is mediated by rhodopsin transport carriers (RTCs)...
  74. pmc Structure and distribution of organelles and cellular location of calcium transporters in Neurospora crassa
    Barry J Bowman
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA 95064, USA
    Eukaryot Cell 8:1845-55. 2009
    ..However, the structure and distribution of organelles in live hyphae of N. crassa have not been comprehensively described...
  75. ncbi Adenine nucleotide transporters in organelles: novel genes and functions
    Javier Traba
    Departamento de Biologia Molecular, Centro de Biología Molecular Severo Ochoa UAM CSIC, CIBER de Enfermedades Raras, Universidad Autonoma de Madrid, Madrid, Spain
    Cell Mol Life Sci 68:1183-206. 2011
    ..This work reviews the carriers that transport adenine nucleotides into the organelles of eukaryotic cells together with their possible functions...
  76. pmc Gene transfer from organelles to the nucleus: frequent and in big chunks
    William Martin
    Institute of Botany III, Universitat Dusseldorf, Universitatstrasse 1, D 40225 Dusseldorf, Germany
    Proc Natl Acad Sci U S A 100:8612-4. 2003
  77. pmc Eukaryotic protein production in designed storage organelles
    Margarita Torrent
    Departament de Genetica Molecular, Consorci CSIC IRTA, Jordi Girona, Barcelona, Spain
    BMC Biol 7:5. 2009
    Protein bodies (PBs) are natural endoplasmic reticulum (ER) or vacuole plant-derived organelles that stably accumulate large amounts of storage proteins in seeds...
  78. ncbi Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation
    Richard Wubbolts
    Department of Cell Biology, Utrecht University Medical Centre and Institute of Biomembranes, Room G02 525, Heidelberglaan 100, 3585 CX Utrecht, The Netherlands
    J Biol Chem 278:10963-72. 2003
  79. ncbi Safranine as a fluorescent probe for the evaluation of mitochondrial membrane potential in isolated organelles and permeabilized cells
    Tiago R Figueira
    Faculdade de Ciencias Medicas, Departamento de Patologia Clinica, Universidade Estadual de Campinas, Campinas, SP 13083 887, Brazil
    Methods Mol Biol 810:103-17. 2012
    ..Here, we describe the use of safranine as a fluorescent indicator of Δψ in isolated mitochondria and digitonin-permeabilized cells. We present suitable conditions to employ safranine as a Δψ indicator...
  80. ncbi Microvesicles derived from mesenchymal stem cells: potent organelles for induction of tolerogenic signaling
    Aram Mokarizadeh
    Division of Immunology, Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
    Immunol Lett 147:47-54. 2012
    ..Recent study suggests MSC-derived MVs as potent organelles for induction of peripheral tolerance and modulation of immune responses.
  81. ncbi Fat on the move: intracellular motion of lipid droplets
    Michael A Welte
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Biochem Soc Trans 37:991-6. 2009
    Lipid droplets are intracellular organelles that play central roles in lipid metabolism. In many cells, lipid droplets undergo active motion, typically along microtubules...
  82. pmc A lumenal domain-dependent pathway for sorting to intralumenal vesicles of multivesicular endosomes involved in organelle morphogenesis
    Alexander C Theos
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Dev Cell 10:343-54. 2006
    ..underlies such cellular processes as receptor downregulation, viral budding, and biogenesis of lysosome-related organelles such as melanosomes...
  83. pmc Surface organelles assembled by secretion systems of Gram-negative bacteria: diversity in structure and function
    David G Thanassi
    Center for Infectious Diseases, Stony Brook University, Stony Brook, NY 11794 5120, USA
    FEMS Microbiol Rev 36:1046-82. 2012
    Gram-negative bacteria express a wide variety of organelles on their cell surface...
  84. pmc Electron microscopic visualization of fluorescent signals in cellular compartments and organelles by means of DAB-photoconversion
    Claudia Meiblitzer-Ruppitsch
    Department of Cell Biology and Ultrastructure Research, Center for Anatomy and Cell Biology, Medical University Vienna, Schwarzspanierstrasse 17, 1090, Vienna, Austria
    Histochem Cell Biol 130:407-19. 2008
  85. ncbi An overview of endosymbiotic models for the origins of eukaryotes, their ATP-producing organelles (mitochondria and hydrogenosomes), and their heterotrophic lifestyle
    W Martin
    , , Germany
    Biol Chem 382:1521-39. 2001
    ..processes underlying the differentness of prokaryotic and eukaryotic cells and the origin of the latter's organelles are still poorly understood...
  86. pmc Diversity and reductive evolution of mitochondria among microbial eukaryotes
    Karin Hjort
    Institute for Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Philos Trans R Soc Lond B Biol Sci 365:713-27. 2010
    ..These organelles have been called hydrogenosomes, when they make hydrogen, or remnant mitochondria or mitosomes when their ..
  87. ncbi Chromatoid bodies: aggresome-like characteristics and degradation sites for organelles of spermiogenic cells
    Celina M Haraguchi
    Biology Laboratory, University of Yamanashi, Yamanashi, Japan
    J Histochem Cytochem 53:455-65. 2005
    ..These results show that the CBs have some aggresomal features, suggesting that they are not a synthetic site as proposed previously but a degradation site where unnecessary DNA, RNA, and proteins are digested...
  88. ncbi Morphology and molecular phylogeny of Trimyema koreanum n. sp., a ciliate from the hypersaline water of a solar saltern
    Byung Cheol Cho
    School of Earth and Environmental Sciences, Seoul National University, Seoul 151 742, Korea
    J Eukaryot Microbiol 55:417-26. 2008
    ..Trimyema koreanum is able to consume both prokaryotes and small eukaryotes (specifically, the alga Dunaliella sp.)...
  89. pmc Possible existence of lysosome-like organella within mitochondria and its role in mitochondrial quality control
    Yuji Miyamoto
    Cancer Medicine and Biophysics Division, National Cancer Center Research Institute, Tokyo, Japan
    PLoS ONE 6:e16054. 2011
    ..without destroying the mitochondrial structure (designated MALM, for Mieap-induced accumulation of lysosome-like organelles within mitochondria) in response to mitochondrial damage. MALM was not related to canonical autophagy...
  90. ncbi RNA editing in plant organelles. Why make it easy?
    B Castandet
    Laboratoire de Microbiologie Cellulaire et Moléculaire et Pathogénicité, UMR5234 CNRS Université Victor Segalen Bordeaux2, Bordeaux, Cedex 33076, France
    Biochemistry (Mosc) 76:924-31. 2011
    Gene expression in plant organelles involves a number of distinct co- or posttranscriptional nucleic acid modifications: 5' and 3' RNA processing, cis- and trans-splicing, RNA stability, and RNA editing...
  91. pmc Bacterial microcompartments: their properties and paradoxes
    Shouqiang Cheng
    Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA
    Bioessays 30:1084-95. 2008
    Many bacteria conditionally express proteinaceous organelles referred to here as microcompartments (Fig. 1). These microcompartments are thought to be involved in a least seven different metabolic processes and the number is growing...
  92. pmc Structural insight into the mechanisms of transport across the Salmonella enterica Pdu microcompartment shell
    Christopher S Crowley
    Molecular Biology Institute, Iowa State University, Ames, Iowa 50011, USA
    J Biol Chem 285:37838-46. 2010
    Bacterial microcompartments are a functionally diverse group of proteinaceous organelles that confine specific reaction pathways in the cell within a thin protein-based shell...
  93. ncbi Polymeric vesicles: from drug carriers to nanoreactors and artificial organelles
    Pascal Tanner
    Department of Chemistry, University of Basel, Klingelbergstrasse 80, CH 4056 Basel, Switzerland
    Acc Chem Res 44:1039-49. 2011
    ..from simple polymeric carriers to smart-complex protein-polymer assemblies, such as nanoreactors or synthetic organelles. Polymeric vesicles generated by the self-assembly of amphiphilic copolymers (polymersomes) offer the advantage ..
  94. ncbi Carboxysomes: cyanobacterial RubisCO comes in small packages
    George S Espie
    Department of Cell and Systems Biology, University of Toronto, Mississauga, ON, Canada
    Photosynth Res 109:7-20. 2011
    ..In this review, we summarize recent advances in understanding the organization and functioning of these intriguing, and ecologically very important molecular machines...
  95. ncbi A new polymorphic methanogen, closely related to Methanocorpusculum parvum, living in stable symbiosis within the anaerobic ciliate Trimyema sp
    B J Finlay
    Institute of Freshwater Ecology, Windermere Laboratory, Ambleside, Cumbria, UK
    J Gen Microbiol 139:371-8. 1993
    ..The symbionts belong to a new species of archaeobacterium which is a close relative of the free-living methanogen Methanocorpusculum parvum...
  96. pmc Myosin XI-K Is required for rapid trafficking of Golgi stacks, peroxisomes, and mitochondria in leaf cells of Nicotiana benthamiana
    Dror Avisar
    Department of Botany and Plant Pathology and Center for Genome Research and Biocomputing, Oregon State University, Corvallis, OR 97331, USA
    Plant Physiol 146:1098-108. 2008
    A prominent feature of plant cells is the rapid, incessant movement of the organelles traditionally defined as cytoplasmic streaming and attributed to actomyosin motility...
  97. pmc Flavodiiron protein from Trichomonas vaginalis hydrogenosomes: the terminal oxygen reductase
    Tamara Smutná
    Department of Parasitology, Charles University, Vinicna, Prague, Czech Republic
    Eukaryot Cell 8:47-55. 2009 equipped with a hydrogenosomal targeting sequence and is expressed in the hydrogenosomes, oxygen-sensitive organelles that participate in carbohydrate metabolism and assemble iron-sulfur clusters...
  98. ncbi Fungal evo-devo: organelles and multicellular complexity
    Gregory Jedd
    Temasek Life Sciences Laboratory and Department of Biological Sciences, The National University of Singapore, Singapore 117604
    Trends Cell Biol 21:12-9. 2011
    ..phyla, and the endoplasmic reticulum (ER)-derived septal pore cap (SPC) of the Basidiomycota, are both fungal organelles that prevent cytoplasmic bleeding when multicellular hyphal filaments are wounded...
  99. pmc In silico identification of specialized secretory-organelle proteins in apicomplexan parasites and in vivo validation in Toxoplasma gondii
    Zhongqiang Chen
    Department of Biology, Penn Genomic Frontiers Institute, and the Graduate Program in Genomics and Computational Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 3:e3611. 2008
    ..including the human pathogens Toxoplasma gondii and Plasmodium falciparum, employ specialized secretory organelles (micronemes, rhoptries, dense granules) to invade and survive within host cells...
  100. pmc TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP
    Michael X Zhu
    Department of Neuroscience and Center for Molecular Neurobiology, The Ohio State University, Columbus, OH, USA
    FEBS Lett 584:1966-74. 2010
    ..With multiple endolysosomal targeted NAADP receptors now identified, important new insights into the regulation of endolysosomal function in health and disease will therefore be unveiled...
  101. ncbi Rosella: a fluorescent pH-biosensor for reporting vacuolar turnover of cytosol and organelles in yeast
    Carlos J Rosado
    Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Victoria, Australia
    Autophagy 4:205-13. 2008
    ..We further demonstrated the value of the biosensor as a reporter of autophagy by employing fluorescence-activated cell sorting of discrete populations of cells undergoing autophagy...

Research Grants72

  1. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  2. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  3. Functional Genomics of the Mitochondrial Proteome
    Dennis R Winge; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Mitochondria are essential organelles for cellular metabolism and survival...
  4. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2011
    ..Autophagy is a conserved process of bulk degradation of cytosol and organelles, which at low levels plays an important role in recycling damaged organelles and recycling nutrients ..
  5. Lipid Droplet Metabolism
    Fredric B Kraemer; Fiscal Year: 2013 the realization that LDs are not simply static repositories for lipid storage, but are dynamic intracellular "organelles" that participate in interactions and interplay with much of the cell's machinery...
  6. Cellular and Animal Models of FUS Mutations in ALS
    Eric J Huang; Fiscal Year: 2013
    ..cytoplasm with abnormal FUS protein aggregates that are associated with markedly disorganized intracellular organelles, including endoplasmic reticulum (ER) and mitochondria...
  7. Identifying all Meckel-like ciliopathy genes by established total exome capture a
    Friedhelm Hildebrandt; Fiscal Year: 2010
    ..Primary cilia are universal sensory organelles that sense cell-external signals...
    John J Lemasters; Fiscal Year: 2012
    ..multiphoton microscopy to visualize parameter- indicating fluorophores inside individual hepatocytes and their organelles in liver grafts of living rats and mice...
  9. Local Calcium Signaling in Pulmonary Arteries
    JAMES SK SHAM; Fiscal Year: 2012
    ..We have recently identified the lysosomal acidic organelles in PASMCs, and detected a lysosome-dependent Ca2+ release induced by the integrin-specific ligand GRGDSP peptide,..
  10. Ca Signaling in Progression of Amyotrophic Lateral Sclerosis in Skeletal Muscle
    Jingsong Zhou; Fiscal Year: 2013
    ..We have discovered uncontrolled hyperactive Ca signals in muscle cells of ALS transgenic mouse model. Two major organelles are involved for the tight control of the intracellular Ca level, the sarcoplasmic reticulum (SR)-the site of Ca ..
  11. Novel genetics, pathobiology &therapy of nephronophthisis-related ciliopathies
    Friedhelm Hildebrandt; Fiscal Year: 2013
    ..PC are sensory organelles expressed by virtually all vertebrate cell types...
  12. Visualization of ototoxic mitochondrial dysfunction in mammalian hair cells
    Shelley A Batts; Fiscal Year: 2012
    ..have been well-established to be the "powerhouse" of the cell by generating most of cells'ATP, but these organelles also have a role in detoxifying the cell from reactive ROS accumulation, regulating Ca[+2] homeostasis, and ..
  13. Fnip1 Function in Lymphocyte Development, Activation and Metabolism
    Brian M Iritani; Fiscal Year: 2013
    ..Fnip1 is essential to "turn off" mTOR mediated nutrient consumption, and "turn on" autophagy (self-digestion of organelles to generate nutrients) in response to nutrient deficit;and (3) To determine the roles of Fnip1 in iNKT cell ..
  14. In vivo analysis of the mechanisms of axon transport.
    Catherine M Drerup; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): In neurons, axonal transport of proteins and organelles to and from synapses is essential for formation and maintenance of neural connectivity...
  15. Nuclear Control of Mitochondrial Gene Expression
    Gerald Shadel; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mitochondria are multi-faceted organelles in eukaryotic cells that stand at the nexus of energy metabolism, oxidative stress, and apoptosis...
    Ralph A Nixon; Fiscal Year: 2013
    ..NF and suggested a novel function for NF as a scaffold in axons and synapses, which reversibly docks vesicular organelles and proteins, including neurotransmitter receptors, and thereby may regulate their function...
  17. Molecular Regulation of Ischemic Renal Failure
    Zheng Dong; Fiscal Year: 2013
    ..In mitochondria, Endo-B1 collaborates with fission-fusion proteins to fragment the organelles, facilitating Bax/Bak oligomerization and formation of pathological pores, resulting in the release of apoptotic ..
  18. Thiol Isomerases During Thrombus Formation
    Barbara C Furie; Fiscal Year: 2013 resting platelets and unstimulated endothelial cells, and localized to either the cell surface or internal organelles, or both, by flow cytometry, immunofluorescence microscopy and electron microscopy...
  19. AAA ATPases linking mitochondria with microtubule processing in flies and yeast
    Karen G Hales; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Mitochondria, the organelles in which food energy is harnessed into usable ATP form, are moved and shaped to fulfill different energy needs within specialized cells...
  20. Control of liver autophagy by phosphatidic acid signaling
    GILBERT DIPAOLO; Fiscal Year: 2013
    ..recycling of macromolecules under conditions of nutritional scarcity, as well as the elimination of defective organelles, long- lived proteins, and intracellular protein aggregates...
  21. Chemical approaches for studying the biology of CD38
    Hening Lin; Fiscal Year: 2013
    ..For example, how CD38 gains access to its NAD or NADP substrate, whether CD38 is present in intracellular organelles, and how the receptor function affects the enzymatic function...
  22. Autophagy in Brain Tumor
    Jin Ming Yang; Fiscal Year: 2013
    ..a conserved response to nutrient/growth factor deprivation and a process of self-digestion of cytoplasm and organelles through which cellular components are recycled for energy utilization, may represent a critical survival ..
    DEBRA LYNN LASKIN; Fiscal Year: 2012
    ..These are specialized organelles that sequester and negatively regulate various cell-signaling molecules...
  24. Disease-related defects in dendritic cell processing of bacterial antigens
    Michael S Marks; Fiscal Year: 2012
    ..the failure to properly form tissue-specific intracellular compartments known collectively as lysosome-related organelles (LROs)...
  25. Skeletal Muscle Mitochondrial Adaptations to a Two-Year Caloric Restiction
    STEVEN RICHARD SMITH; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: The energy producing cellular organelles called mitochondria produce free radicals producing oxidative stress...
  26. Heme Oxygenase Enzymes/Carbon Monoxide in Hepatic Dysfunction from hemorrhage
    BRIAN SCOTT ZUCKERBRAUN; Fiscal Year: 2013
    ..Specific Aim II. To determine the protective role of mitochondria as signaling organelles in hemorrhage/resuscitation and the mechanisms of regulation by HO/CO...
  27. Autophagy and human islet amyloid polypeptide in animal models of type 2 diabetes
    Jacqueline Rivera; Fiscal Year: 2013
    ..The cellular process designated to clear intracellular oligomers and damaged organelles in long lived cells, such as beta-cells, is autophagy...
  28. Neuroimmune modulation across the BBB: Regulation of ILS trafficking by TNF
    Weihong Pan; Fiscal Year: 2012
    ..turnover assays, confocal analyses of time-dependent colocalization of IL15, its receptors, and intracellular organelles, and quantification by enzyme-linked immunosorbent assay...
  29. Reciprocal Control of Motility and Adherence in UTI
    Harry L Mobley; Fiscal Year: 2013
    ..However the actions of the two organelles have opposite functions. We reason that there is a time to swim and a time to adhere...
  30. Redox Regulation of Lung Mitochondrial Biogenesis in Sepsis/Pneumonia
    Claude A Piantadosi; Fiscal Year: 2013
    ..protect energy metabolism and mitochondrial mass, but which we think may also promote the clearance of damaged organelles (mitophagy) and limit further inflammatory damage in MODS...
  31. The role of acyl-CoA binding proteins in selective autophagy
    Taras Y Nazarko; Fiscal Year: 2013
    ..Obesity specifically refers to an excessive amount of adipose tissue, where lipids are stored in specialized organelles called lipid droplets (LDs)...
  32. Role of Tumor and Stromal Cell Metabolism in Stress Adaptation and Progression
    EILEEN contact WHITE; Fiscal Year: 2010
    ..self-consumption and recycling, and by mitigating oxidative damage through the degradation of malfunctioning organelles and proteins...
  33. Rescuing Niemann-Pick C Disease: Pathways of Liver and Brain Degeneration
    Matthew P Scott; Fiscal Year: 2013
    ..In living brains of our newly engineered mice we will analyze movements of Npc1-positive organelles in PNs, other neurons, and astrocytes to determine what changes may cause cell death...
  34. Role of aberrant organelle stress responses in alcohol-induced liver injury
    Cheng Ji; Fiscal Year: 2012
    ..very complex and undoubtedly involves the interplay of multiple mechanisms and pathways, dysfunction of cellular organelles, and interactions of intrinsic and environmental factors...
  35. Mechanisms of Cell Death after Photodynamic Therapy
    Anna Liisa Nieminen; Fiscal Year: 2010
    ..We hypothesize that damage to these organelles by PC 4 and PC 181 leads to additional perturbations, such as Ca2+, iron and protease release that ultimately ..
  36. Role of NADPH oxidase 1-derived ROS in the pathogenesis of Parkinson's disease
    Yoon Seong Kim; Fiscal Year: 2012
    ..ROS are physiologic byproduct of several organelles and biological reactions including mitochondria, peroxisomes, cytochrome P-450, xanthine oxidase, cyclooxygenase ..
  37. The role of two-pore channels in integrative calcium signaling
    Michael X Zhu; Fiscal Year: 2013
    ..Recent studies indicate that NAADP mobilizes Ca2+ from lysosome-related acidic organelles;however, the molecular identity of the Ca2+ release channels and the specific internal stores involved in NAADP-..
  38. Encapsidation of the poxvirus genome
    Paula Traktman; Fiscal Year: 2012
    ..As a result, the progression of the viral life cycle is intimately linked to interactions with the organelles, cytoskeleton and cytoplasmic milieu of the host cell...
  39. RPE Phenotype and Oxidative Stress
    Janice M Burke; Fiscal Year: 2013 studied to determine how it interferes with the ability of RPE cells to move sub-cellular components called organelles, which must be effectively and continuously moved to achieve the most efficient cell architecture...
  40. Role of Autophagy in Cancer
    Eileen White; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cells capture intracellular proteins and organelles by the process of macroautophagy (autophagy hereafter), which delivers them to lysosomes where they are degraded...
  41. FRET-based Biosensors to Monitor Redox in Cell Cycle Regulation
    Paul J A Kenis; Fiscal Year: 2012
    ..Specifically, we intend to quantify differences in redox potentials within subcellular organelles that are at a nonequilibrium steady-state with respect to each other in living cells...
  42. Centrosomin and Centrosomes in Cell Division
    Timothy L Megraw; Fiscal Year: 2012
    Centrioles and centrosomes are conserved organelles in animals that are essential for cell signaling, cell division, and for specialized roles in differentiated cells, impacting organ function in whole animals...
  43. Ethanol Regulates Vacuolar ATPase &PEDF
    Chuhan Chung; Fiscal Year: 2013
    ..The v-ATPase is a highly regulated proton pump that functions to move protons into organelles and out into the extracellular space...
    MARK A MC NIVEN; Fiscal Year: 2013
    ..and cargo proteins are differentially sorted into vesicle carriers for subsequent trafficking to distinct organelles. The information gathered by these studies will help identify strategies for the treatment and prevention of ..
  45. Identification of Muscle-Specific Biomarkers of Fatty Acid beta-Oxidation
    SEAN HARRISON ADAMS; Fiscal Year: 2012
    ..derived from biological systems displaying disparate muscle fat combustion, including: isolated mitochondrial organelles and muscle cells catabolizing FA at different rates, a UCP3 transgenic animal model, and human subjects ..
  46. Functional consequences of autophagy mutations in Crohn's disease.
    David L Boone; Fiscal Year: 2012
    ..Autophagy is thus employed by cells during times of nutrient deprivation to reclaim amino acids from cellular organelles. Autophagy is also involved in the turnover of large proteins or protein complexes, cell death and antigen ..
    Kevin M Smith; Fiscal Year: 2013
    ..The tetrapyrrole photosensitizers that are synthesized will be directed to specific organelles (preferably the mitochondria) by conjugation with one or more amino acid, short peptide, or PEG of defined ..
  48. Lipid Activated Nuclear Receptors in Age-Related Macular Degeneration
    Goldis Malek; Fiscal Year: 2013
    ..of dietary fatty acids, including n-6 PUFAs, on gene expression and stimulates the proliferation of peroxisomes, organelles involved in fatty acid oxidation...
  49. Optical spectroscopy to study mitochondrial function within replicating cells
    Roger J Springett; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Mitochondria are subcellular organelles that generate ATP, control apoptotic cell death, buffer intracellular calcium and generate reactive oxygen species and free radicals...
  50. The in vivo role of the mitochondrial p53 cell death program
    UTE MARTHA MOLL; Fiscal Year: 2013
    ..This is the thrust of this proposal. Furthermore, this proposal aims at gaining more mechanistic insight into how p53 works at the mitochondria to permeabilize these organelles.
    Susan K Dutcher; Fiscal Year: 2013
    ..The structure and composition of these organelles is conserved among organisms...
  52. Physiology of Class III PI 3-kinase Signaling 2
    Jonathan M Backer; Fiscal Year: 2013
    ..stress, in which the formation of a double-walled membrane structure sequesters cytosolic components and organelles and delivers them to the lysosome for degradation. This liberates nutrients for use in new biosynthetic activity...
  53. Direct Regulation of Mitochondrial Transcription by Thyroid Hormone and Receptor
    MEGAN LYNN BESTWICK; Fiscal Year: 2012
    ..These are unique organelles in that they house their own mitochondrial genome (mtDNA) as well as their own DNA replication, transcription ..
  54. Respiratory and Metabolic Adaptation to Hypoxia
    Paul T Schumacker; Fiscal Year: 2013
    ..We hypothesize that mitochondria function as hypoxia sensors in the cell. These organelles appear to trigger adaptive responses by initiating a signaling cascade involving an increased release of ..
  55. Hypothalamic autophagy and metabolic regulation in aging
    Rajat Singh; Fiscal Year: 2013
    ..Macroautophagy (MA) is an essential mechanism that maintains cellular homeostasis by degrading proteins and organelles in lysosomes...
  56. The amelioration of peroxisomal disorders due to defects in Pex10
    Lee A Niswander; Fiscal Year: 2013
    Project Summary/Abstract Peroxisomes are enzyme-containing membrane organelles that are involved in the detoxification of reactive oxygen species, the catabolism of very long chain fatty acids and the biosynthesis of plasmalogens...
  57. Thioredoxin and Endothelial Cell Function
    Wang Min; Fiscal Year: 2012
    ..recent data suggest that mitochondria normally produce the strongest reducing environment among all cellular organelles, and mitochondria are especially vulnerable to oxidation in response to stress stimuli including proinflammatory ..
  58. Receptor-mediated Endocytosis-Mechanism and Function
    Frederick R Maxfield; Fiscal Year: 2013
    ..Delivery of these proteins to late endosomes and lysosomes is essential for proper acidification of these organelles In microglial cells...
  59. The role of phosphorylation of Ulk1 by GSK-3b in myocardial autophagy and aging
    Peiyong Zhai; Fiscal Year: 2013
    ..that a decrease in autophagy activity may play a major role in accumulation of altered macromolecules and organelles, causing aging-related abnormalities...
  60. Regulation of mitochondrial oxidative stress by Bcl-2 family proteins
    DANIEL LINSEMAN; Fiscal Year: 2011
    ..Although Bcl-2 protein signaling and oxidative stress at mitochondria (organelles that supply the cell with energy) markedly influence nerve cell survival and death, little is known about how ..
  61. Role of Ion Channel in Mononuclear Phagocyte Activation
    Deborah J Nelson; Fiscal Year: 2012
    ..pumps are various channels that shunt the transmembrane potential generated by movement of protons;in different organelles these comprise H+ channels, K+ channels and Cl- channels...
  62. Cellular and molecular mechanisms of gp120 neurotoxicity
    Italo Mocchetti; Fiscal Year: 2012
    ..will be accompanied by histological analysis of gp120 immunoreactivity within endosomes or other cellular organelles, as well as by biochemical analyses of pro-inflammatory cytokines...
    DOUGLAS COLE; Fiscal Year: 2009
    ..Motile forms of these organelles are capable of propelling some cells like sperm and protozoa through a liquid environment while other cells like ..
  64. Conferene on the basic cell and molecular biology of cilia and flagella as relate
    Joel Rosenbaum; Fiscal Year: 2007
    ..cell and molecular biology of cilia and flagella have led to an increase in not only basic research on these organelles, but clinical research related to the role of cilia and flagella in certain diseases...
    RAKESH KUKREJA; Fiscal Year: 1990
    ..g., adriamycin). We have hypothesized that the major target organelles injured by free radical attack are the sarcolemma and sarcoplasmic reticulum which are the key regulators of ..
  66. Role of BLOC-3 in Lysosome and Melanosome Biogenesis
    ESTEBAN DELL ANGELICA; Fiscal Year: 2007
    Melanosomes are cell-type-specific, membrane-bounded organelles in which melanin pigments are synthesized and stored...
  67. Regulated Assembly of Subcellular Structures in alpha-Proteobacteria
    JOSEPH CHIUNG CHU CHEN; Fiscal Year: 2010
    Bacterial cells have evolved multiple regulatory mechanisms to ensure that their subcellular structures and organelles, such as pili and flagella, are assembled and positioned correctly...
    Raymond Boissy; Fiscal Year: 2002
    ..These characteristics result from aberrations in a specific group of cellular organelles, (i.e...
  69. PPK Dependent Acidocalcisome-like Granules, Polyphosphates and Helicobacter
    Manfredo J Seufferheld; Fiscal Year: 2010
    ..the overall hypothesis that Helicobacter pylori acidocalcisome-like granule (ALGs) are polyphosphate-rich organelles. Dense volutin granules have been previously described in the cytosol of H...
  70. A novel vacuolar compartment in Toxoplasma gondii
    Silvia N Moreno; Fiscal Year: 2010
    ..Biogenesis of these organelles remains poorly understood but several groups have postulated a compartment situated between Golgi and mature ..
  71. Genetic and Biochemical Analyses of Germline Development in Drosophila
    Alexey Arkov; Fiscal Year: 2009
    ..The landmarks of the germline are special organelles, which contain factors necessary for germ cell development including Oskar and Tudor...
    STEVEN L HERNAULT; Fiscal Year: 2003
    When cells divide, organelles and macromolecules can be partitioned unequally between daughters...