Genomes and Genes
Summary: The network of filaments, tubules, and interconnecting filamentous bridges which give shape, structure, and organization to the cytoplasm.
Publications409 found, 100 shown here
- Matrix elasticity directs stem cell lineage specificationAdam J Engler
Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, 19104, USA
Cell 126:677-89. 2006..The results have significant implications for understanding physical effects of the in vivo microenvironment and also for therapeutic uses of stem cells...
- Lifeact: a versatile marker to visualize F-actinJulia Riedl
Max Planck Institute of Biochemistry, Independent Junior Research Group Cellular Dynamics and Cell Patterning, Am Klopferspitz 18, 82152 Martinsried, Germany
Nat Methods 5:605-7. 2008Live imaging of the actin cytoskeleton is crucial for the study of many fundamental biological processes, but current approaches to visualize actin have several limitations...
- Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitmentRowena McBeath
The Cellular and Molecular Medicine Program, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Dev Cell 6:483-95. 2004..These studies demonstrate that mechanical cues experienced in developmental and adult contexts, embodied by cell shape, cytoskeletal tension, and RhoA signaling, are integral to the commitment of stem cell fate...
- Rho GTPases and the actin cytoskeletonA Hall
Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
Science 279:509-14. 1998The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic cells...
- Actin, a central player in cell shape and movementThomas D Pollard
Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520 8103, USA
Science 326:1208-12. 2009..Comparisons of quantitative measurements of reactions in live cells with computer simulations of mathematical models will also help generate meaningful insights...
- Tensional homeostasis and the malignant phenotypeMatthew J Paszek
Department of Bioengineering, University of Pennsylvania, Philadelphia, 19104, USA
Cancer Cell 8:241-54. 2005..Thus, ERK and Rho constitute part of an integrated mechanoregulatory circuit linking matrix stiffness to cytoskeletal tension through integrins to regulate tissue phenotype...
- Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeletonD D Sarbassov
Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
Curr Biol 14:1296-302. 2004..a rapamycin-insensitive TOR complex that does not contain the yeast homolog of raptor and signals to the actin cytoskeleton through PKC1...
- Focal adhesion kinase: in command and control of cell motilitySatyajit K Mitra
The Scripps Research Institute, Department of Immunology, IMM21 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Rev Mol Cell Biol 6:56-68. 2005..Through multifaceted and diverse molecular connections, FAK can influence the cytoskeleton, structures of cell adhesion sites and membrane protrusions to regulate cell movement.
- EMT, the cytoskeleton, and cancer cell invasionMahmut Yilmaz
Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
Cancer Metastasis Rev 28:15-33. 2009..processes to gain migratory and invasive properties that involve a dramatic reorganization of the actin cytoskeleton and the concomitant formation of membrane protrusions required for invasive growth...
- Tissue cells feel and respond to the stiffness of their substrateDennis E Discher
School of Engineering and Applied Science and Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104 6315, USA
Science 310:1139-43. 2005..Key roles in molecular pathways are played by adhesion complexes and the actinmyosin cytoskeleton, whose contractile forces are transmitted through transcellular structures...
- Post-translational regulation of the microtubule cytoskeleton: mechanisms and functionsCarsten Janke
Department of Signalling, Neurobiology and Cancer, Institut Curie, Bat 110, Centre Universitaire, 91405 Orsay Cedex, France
Nat Rev Mol Cell Biol 12:773-86. 2011....
- The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factorsA J Ridley
Institute for Cancer Research, Chester Beatty Laboratories, London, England
Cell 70:389-99. 1992..These data imply that rho is essential specifically for the coordinated assembly of focal adhesions and stress fibers induced by growth factors...
- Integrin signalingF G Giancotti
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Science 285:1028-32. 1999..kinases, growth factor receptors, and ion channels and control the organization of the intracellular actin cytoskeleton. Many integrin signals converge on cell cycle regulation, directing cells to live or die, to proliferate, or to ..
- Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitiveEstela Jacinto
Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
Nat Cell Biol 6:1122-8. 2004..TORC2, mTORC2 is rapamycin insensitive and seems to function upstream of Rho GTPases to regulate the actin cytoskeleton. mTORC2 is not upstream of the mTORC1 effector S6K...
- The molecular motor toolbox for intracellular transportRonald D Vale
Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Cell 112:467-80. 2003..Remarkably, fungi, parasites, plants, and animals have distinct subsets of Toolbox motors in their genomes, suggesting an underlying diversity of strategies for intracellular transport...
- T cell activationJennifer E Smith-Garvin
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Annu Rev Immunol 27:591-619. 2009..complex (MHC) complex pSMAC: peripheral supramolecular activation cluster PTK: protein tyrosine kinase Signal transduction: biochemical events linking surface receptor engagement to cellular responses TCR: T cell antigen receptor..
- Dual-objective STORM reveals three-dimensional filament organization in the actin cytoskeletonKe Xu
Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA
Nat Methods 9:185-8. 2012..we resolved individual actin filaments in cells and revealed three-dimensional ultrastructure of the actin cytoskeleton. We observed two vertically separated layers of actin networks with distinct structural organizations in sheet-..
- Endothelial cell migration during angiogenesisLaurent Lamalice
Le Centre de recherche en cancérologie, l Université Laval, L Hôtel Dieu de Québec, Quebec, Canada
Circ Res 100:782-94. 2007..The aim of this review is to give an integrative view of the signaling mechanisms that govern endothelial cell migration in the context of angiogenesis...
- Adhesion signaling - crosstalk between integrins, Src and RhoStephan Huveneers
Division of Toxicology, Leiden Amsterdam Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands
J Cell Sci 122:1059-69. 2009..Integrins sense the physical properties of the extracellular matrix and organize the cytoskeleton accordingly...
- Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridgesDaniel A Starr
Department of Molecular and Cellular Biology, University of California, Davis, California 95616, USA
Annu Rev Cell Dev Biol 26:421-44. 2010The nuclear envelope links the cytoskeleton to structural components of the nucleus. It functions to coordinate nuclear migration and anchorage, organize chromatin, and aid meiotic chromosome pairing...
- Septins: the fourth component of the cytoskeletonSerge Mostowy
Institut Pasteur, Unité des Interactions Bactéries Cellules, Département de Biologie Cellulaire et Infection, F 75015 Paris, France
Nat Rev Mol Cell Biol 13:183-94. 2012..of proteins that is highly conserved in eukaryotes and is increasingly recognized as a novel component of the cytoskeleton. All septins are GTP-binding proteins that form hetero-oligomeric complexes and higher-order structures, ..
- Integrins: bidirectional, allosteric signaling machinesRichard O Hynes
Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 110:673-87. 2002..between their extracellular ligand binding adhesion sites and their cytoplasmic domains, which link to the cytoskeleton and to signal transduction pathways...
- Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarityMutsuki Amano
Department of Cell Pharmacology, Nagoya University, Showa Ku, Japan
Cytoskeleton (Hoboken) 67:545-54. 2010..This review focuses on the structure, function, and modes of activation and action of Rho-kinase...
- Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikisBin Zhao
Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, China
Genes Dev 26:54-68. 2012..However, little is known about the signals that regulate the Hippo pathway. Here we report that through cytoskeleton reorganization, cell detachment activates the Hippo pathway kinases Lats1/2 and leads to YAP phosphorylation ..
- Rho GTPases and cell migrationA J Ridley
Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, UK
J Cell Sci 114:2713-22. 2001Cell migration involves dynamic and spatially regulated changes to the cytoskeleton and cell adhesion. The Rho GTPases play key roles in coordinating the cellular responses required for cell migration...
- Vinculin controls focal adhesion formation by direct interactions with talin and actinJonathan D Humphries
Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Manchester M13 9PT, England, UK
J Cell Biol 179:1043-57. 2007..The vinculin tail, however, is responsible for the functional link of FAs to the actin cytoskeleton. We propose a new model that explains how vinculin orchestrates FAs.
- Functional atlas of the integrin adhesomeRonen Zaidel-Bar
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel
Nat Cell Biol 9:858-67. 2007..We discuss the role of the different network modules in regulating the structural and signalling functions of cell-matrix adhesions...
- Native ultrastructure of the red cell cytoskeleton by cryo-electron tomographyANDREA NANS
Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York, USA
Biophys J 101:2341-50. 2011Erythrocytes possess a spectrin-based cytoskeleton that provides elasticity and mechanical stability necessary to survive the shear forces within the microvasculature...
- The matrix corroded: podosomes and invadopodia in extracellular matrix degradationStefan Linder
Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Pettenkoferstr 9, 80336 Munchen, Germany
Trends Cell Biol 17:107-17. 2007..This review highlights important new developments in the field, discusses the common and divergent features of podosomes and invadopodia and summarizes current knowledge about matrix-degrading proteinases at these structures...
- Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeletonCarsten Janke
Institut Curie, Batiment 110, Centre Universitaire, F 91405 Orsay cedex, France
Trends Neurosci 33:362-72. 2010..of these modifications and provided first insights into their potential functions in regulating the microtubule cytoskeleton. By contrast, several tubulin-modifying enzymes were only discovered in the last few years, and studies on ..
- Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell linesP Mundel
Department of Anatomy and Cell Biology, University of Heidelberg, Germany
Exp Cell Res 236:248-58. 1997..Therefore, the determinative steps of podocyte differentiation and process formation are studied for the first time using an inducible in vitro model...
- Biology of the p21-activated kinasesGary M Bokoch
Departments of Immunology and Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Annu Rev Biochem 72:743-81. 2003..We propose here a key role for PAK action in coordinating the dynamics of the actin and microtubule cytoskeletons during directional motility of cells, as well as in other functions requiring cytoskeletal polarization...
- Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesionTony Yeung
Institute for Medicine and Engineering, University of Pennsylvania, PA 19104, USA
Cell Motil Cytoskeleton 60:24-34. 2005..These results support the hypothesis that mechanical factors impact different cell types in fundamentally different ways, and can trigger specific changes similar to those stimulated by soluble ligands...
- Subversion of the actin cytoskeleton during viral infectionMatthew P Taylor
Department of Molecular Biology, Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08544, USA
Nat Rev Microbiol 9:427-39. 2011..describe how the interaction of viral proteins with the cell modulates the structure and function of the actin cytoskeleton to initiate, sustain and spread infections...
- The small GTP-binding protein rac regulates growth factor-induced membrane rufflingA J Ridley
Institute for Cancer Research, Chester Beatty Laboratories, London, England
Cell 70:401-10. 1992..We propose that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin...
- The LIM domain: from the cytoskeleton to the nucleusJulie L Kadrmas
Huntsman Cancer Institute and the Department of Biology, University of Utah, 2000 East, Circle of Hope, Salt Lake City, Utah 84112, USA
Nat Rev Mol Cell Biol 5:920-31. 2004..An emerging theme is that LIM proteins might function as biosensors that mediate communication between the cytosolic and the nuclear compartments...
- The cytoskeleton and cancerAlan Hall
Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Cancer Metastasis Rev 28:5-14. 2009..These are all aspects of cell behavior than often go awry in cancer. This volume brings together those interested in understanding the contribution of the actin and microtubule cytoskeletons to the cell biology of cancer...
- The evolution of the cytoskeletonBill Wickstead
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England, UK
J Cell Biol 194:513-25. 2011The cytoskeleton is a system of intracellular filaments crucial for cell shape, division, and function in all three domains of life...
- Integration of contractile forces during tissue invaginationAdam C Martin
Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
J Cell Biol 188:735-49. 2010Contractile forces generated by the actomyosin cytoskeleton within individual cells collectively generate tissue-level force during epithelial morphogenesis...
- Hydrostatic pressure and the actomyosin cortex drive mitotic cell roundingMartin P Stewart
ETH Zurich, Department of Biosystems Science and Engineering, CH 4058 Basel, Switzerland
Nature 469:226-30. 2011..We find that this mitotic rounding force depends both on the actomyosin cytoskeleton and the cells' ability to regulate osmolarity. The rounding force itself is generated by an osmotic pressure...
- Cytoskeletal regulation of pulmonary vascular permeabilityS M Dudek
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
J Appl Physiol 91:1487-500. 2001..Both competing forces in this model are intimately linked through the endothelial cytoskeleton, a complex network of actin microfilaments, microtubules, and intermediate filaments, which combine to regulate ..
- Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteinsToshiki Itoh
Department of Cell Biology and Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Dev Cell 9:791-804. 2005..We report here that a family of proteins previously implicated in the regulation of the actin cytoskeleton also have powerful lipid bilayer-deforming properties via an N-terminal module (F-BAR) similar to the BAR ..
- Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositidesJuha Saarikangas
Program in Cell and Molecular Biology, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
Physiol Rev 90:259-89. 2010The plasma membrane and the underlying cortical actin cytoskeleton undergo continuous dynamic interplay that is responsible for many essential aspects of cell physiology...
- Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeletonPaul U Cameron
Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria 3004, Australia
Proc Natl Acad Sci U S A 107:16934-9. 2010..We propose a unique pathway for establishment of latency by direct HIV-1 infection of resting CD4(+) T cells during normal chemokine-directed recirculation of CD4(+) T cells between blood and tissue...
- Neuronal polarization: the cytoskeleton leads the wayMichael Stiess
Axonal Growth and Regeneration Group, Max Planck Institute of Neurobiology, Am Klopferspitz 18, Martinsried, Germany
Dev Neurobiol 71:430-44. 2011..This process of neuronal polarization is driven by the cytoskeleton. The first and decisive event during neuronal polarization is the specification of the axon...
- Differential gene regulation under altered gravity conditions in follicular thyroid cancer cells: relationship between the extracellular matrix and the cytoskeletonClaudia Ulbrich
Institute of Clinical Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Berlin, Germany
Cell Physiol Biochem 28:185-98. 2011..After 22 s microgravity, the F-actin and cytokeratin cytoskeleton was altered, and ACTB and KRT80 mRNAs were significantly upregulated after the first and thirty-first parabolas...
- Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffnessP J Stewart-Hutchinson
Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
Exp Cell Res 314:1892-905. 2008..within the perinuclear space establish physical connections, called LINC complexes, between the nucleus and the cytoskeleton. Here, we show that the KASH domains of Nesprins 1, 2 and 3 interact promiscuously with luminal domains of Sun1 ..
- Bringing KASH under the SUN: the many faces of nucleo-cytoskeletal connectionsDavid Razafsky
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
J Cell Biol 186:461-72. 2009..However, the recent identification of evolutionarily conserved linkers of the nucleoskeleton to the cytoskeleton (LINC) complexes, a family of macromolecular assemblies that span the double membrane of the nuclear envelope, ..
- Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganizationN Yang
Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
Nature 393:809-12. 1998..Furthermore, insulin and an active form of Rac increase the activity of LIMK-1. Taken together, our results indicate that LIMK-1 participates in Rac-mediated actin cytoskeletal reorganization, probably by phosphorylating cofilin...
- Cell-matrix adhesionAllison L Berrier
Katrina Visiting Faculty Program, National Center on Minority Health and Health Disparities, National Institutes of Health, Bethesda, Maryland, USA
J Cell Physiol 213:565-73. 2007..The review concludes by speculating on the application of this knowledge of cell-matrix interactions in the formation of cell adhesions, assembly of matrix, migration, and tumorigenesis to potential future therapeutic approaches...
- A tale of two PaksLuis E Arias-Romero
Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, U S A
Biol Cell 100:97-108. 2008..In this review, we discuss recent advances in our understanding of the structure, regulation and function of these kinases, emphasizing the many differences between these two groups of signalling proteins...
- Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesisLoukia Parisiadou
Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD 20892, USA
J Neurosci 29:13971-80. 2009..These data support a model in which the G2019S mutation of LRRK2 causes a gain-of-function effect that perturbs the homeostasis of pERM and F-actin in sprouting neurites critical for neuronal morphogenesis...
- Adherens and tight junctions: structure, function and connections to the actin cytoskeletonAndrea Hartsock
Departments of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305 5430, USA
Biochim Biophys Acta 1778:660-9. 2008..Both junctional complexes are proposed to associate with the actin cytoskeleton, and formation and maturation of cell-cell contacts involves reorganization of the actin cytoskeleton...
- The relationship between force and focal complex developmentCatherine G Galbraith
Duke University Medical Center, Durham, NC 27710, USA
J Cell Biol 159:695-705. 2002....
- Sticky business: orchestrating cellular signals at adherens junctionsMirna Perez-Moreno
Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
Cell 112:535-48. 2003..Deciphering the underlying mechanisms that govern these conserved cellular rearrangements is a prerequisite to understanding vertebrate morphogenesis...
- Regulation of cancer cell motility through actin reorganizationDaisuke Yamazaki
Department of Biochemistry, Institute of Medical Science, University of Tokyo, Minato ku, Japan
Cancer Sci 96:379-86. 2005..The different types of cell migration are regulated by different mechanisms. Reorganization of the actin cytoskeleton is the primary mechanism of cell motility and is essential for most types of cell migration...
- Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeletonAndreas Wicki
Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, Center of Biomedicine, University of Basel, 4058 Basel, Switzerland
Cancer Cell 9:261-72. 2006..In conclusion, podoplanin induces an alternative pathway of tumor cell invasion in the absence of epithelial-mesenchymal transition (EMT)...
- HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactionsAgustin Valenzuela-Fernandez
Departamento de Medicina Física y Farmacología, Facultad de Medicina and Instituto de Tecnologías Biomédicas ITB, Universidad de La Laguna, Tenerife, Spain
Trends Cell Biol 18:291-7. 2008..examines the biological actions of HDAC6, focusing on its deacetylase activity and its potential scaffold functions in the regulation of cell migration and other key biological processes in which the cytoskeleton plays an important role.
- Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signalingPaolo P Provenzano
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
J Cell Sci 124:1195-205. 2011..mediated by Rho GTPases, to provide a functional linkage through which forces are transmitted through the cytoskeleton by intracellular force-generating proteins...
- Cadherin junctions and their cytoskeleton(s)William M Brieher
Department of Cell and Developmental Biology, University of Illinois, Urbana, IL 61801, USA
Curr Opin Cell Biol 25:39-46. 2013Classical cadherin adhesion receptors exert many of their biological effects through close cooperation with the cytoskeleton. Much attention has focused on attempting to understand the physical interactions between cadherin molecular ..
- Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticityLiqun Luo
Department of Biological Sciences, Neurosciences Program, Stanford University, California 94305, USA
Annu Rev Cell Dev Biol 18:601-35. 2002The actin cytoskeleton plays a major role in morphological development of neurons and in structural changes of adult neurons...
- Viral interactions with the cytoskeleton: a hitchhiker's guide to the cellKerstin Radtke
Institute of Virology, OE5230, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
Cell Microbiol 8:387-400. 2006The actin and microtubule cytoskeleton play important roles in the life cycle of every virus...
- mTOR regulates expression of slit diaphragm proteins and cytoskeleton structure in podocytesBeate Vollenbröker
UKM, Medizinische Klinik und Poliklinik D, Abteilung Molekulare Nephrologie, Domagkstr 3A, D 48149 Munster, Germany
Am J Physiol Renal Physiol 296:F418-26. 2009..Our data provide new molecular insights explaining which pathways and molecules are affected in podocytes by an imbalanced mTOR function because of rapamycin treatment...
- The mechanical integrin cycleEileen Puklin-Faucher
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
J Cell Sci 122:179-86. 2009..mechanotransduction is the cycle by which integrins bind to the matrix at the leading cell edge, attach to the cytoskeleton, transduce mechanical force, aggregate in the plasma membrane as part of increasingly strengthened adhesion ..
- Cell mechanics and the cytoskeletonDaniel A Fletcher
Bioengineering and Biophysics, University of California, Berkeley, California 94720, USA
Nature 463:485-92. 2010..cell to resist deformation, to transport intracellular cargo and to change shape during movement depends on the cytoskeleton, an interconnected network of filamentous polymers and regulatory proteins...
- A family of intermediate filament-like proteins is sequentially assembled into the cytoskeleton of Toxoplasma gondiiBrooke R Anderson-White
Department of Biology, Boston College, Chestnut Hill, MA, USA
Cell Microbiol 13:18-31. 2011..The cytoskeleton of Toxoplasma, which is composed of microtubules associated with an inner membrane complex (IMC), has an ..
- Nesprins LINC the nucleus and cytoskeletonJason A Mellad
BHF Centre of Research Excellence, Division of Cardiovascular Medicine, King s College London, SE5 9NU, UK
Curr Opin Cell Biol 23:47-54. 2011..proteins, nesprins co-ordinate and maintain cellular architecture by linking membranous organelles to the cytoskeleton. However nuclear envelope (NE) nesprins, uniquely hardwire the nuclear lamina to the cytoskeleton and molecular ..
- Organisation and regulation of the cytoskeleton in plant programmed cell deathA Smertenko
School of Biological and Biomedical Sciences, Durham University, Durham, DH1 3LE, UK
Cell Death Differ 18:1263-70. 2011..Signalling to PCD results in major reorganisation of cellular components. The plant cytoskeleton is known to play a major role in cellular organisation, and reorganization and alterations in its dynamics is a ..
- Growth control by committee: intercellular junctions, cell polarity, and the cytoskeleton regulate Hippo signalingJulian C Boggiano
Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA
Dev Cell 22:695-702. 2012..In this review, we discuss recent findings that emphasize the cell cortex-specifically the actin cytoskeleton, intercellular junctions, and protein complexes that determine cell polarity-as a key site for Hippo pathway ..
- Rho GTPases and actin dynamics in membrane protrusions and vesicle traffickingAnne J Ridley
Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK
Trends Cell Biol 16:522-9. 2006....
- Adhesion-dependent cell mechanosensitivityAlexander D Bershadsky
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
Annu Rev Cell Dev Biol 19:677-95. 2003..At these sites, transmembrane integrin receptors are associated via their cytoplasmic domains with the actin cytoskeleton. This interaction with actin is mediated by a submembrane plaque, consisting of numerous cytoskeletal and ..
- Small GTP-binding proteinsY Takai
Department of Molecular Biology, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Japan
Physiol Rev 81:153-208. 2001..Cascades and cross-talks of small G proteins have also been clarified. In this review, functions of small G proteins and their modes of activation and action are described...
- FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in oneHarold P Erickson
Department of Cell Biology, Box 3709, Duke University Medical Center, Durham, NC 27710, USA
Microbiol Mol Biol Rev 74:504-28. 2010..Recent efforts to develop antibacterial drugs that target FtsZ are reviewed. Finally, we discuss evidence of how FtsZ generates a constriction force: by protofilament bending into a curved conformation...
- Actin dynamics at the leading edge: from simple machinery to complex networksRobert H Insall
CRUK Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland
Dev Cell 17:310-22. 2009..Migration requires the actin cytoskeleton, specifically the localized polymerization of actin filaments underneath the plasma membrane...
- Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosisS Kothakota
Chiron Corporation, Emeryville, CA 94608, USA
Science 278:294-8. 1997..Thus, cleaved gelsolin may be one physiological effector of morphologic change during apoptosis...
- IQGAP1 in cellular signaling: bridging the GAPMatthew D Brown
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Trends Cell Biol 16:242-9. 2006..It modulates the actin cytoskeleton through Rac1 and Cdc42, and cell-cell adhesion through E-cadherin and beta-catenin...
- Hts/Adducin controls synaptic elaboration and eliminationJan Pielage
Department of Biochemistry and Biophysics, University of California, San Francisco, 1550 4 th Street, San Francisco, CA 94158, USA
Neuron 69:1114-31. 2011..Hts/Adducin may define a mechanism to switch between synapse stability and dynamics...
- The interaction between nesprins and sun proteins at the nuclear envelope is critical for force transmission between the nucleus and cytoskeletonMaria L Lombardi
Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Cambridge, Massachusetts 02139, USA
J Biol Chem 286:26743-53. 2011Maintaining physical connections between the nucleus and the cytoskeleton is important for many cellular processes that require coordinated movement and positioning of the nucleus...
- How HIV takes advantage of the cytoskeleton in entry and replicationBettina Stolp
Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg, Germany
Viruses 3:293-311. 2011The host cell cytoskeleton plays a key role in the life cycle of viral pathogens whose propagation depends on mandatory intracellular steps...
- Two components of actin-based retrograde flow in sea urchin coelomocytesJ H Henson
Department of Biology, Dickinson College, Carlisle, Pennsylvania 17013, USA
Mol Biol Cell 10:4075-90. 1999..Inhibition of actin polymerization with cytochalasin D caused the actin cytoskeleton to separate from the cell margin and undergo a finite retrograde retraction...
- Podocyte biology and response to injuryPeter Mundel
Division of Nephrology, Albert Einstein College of Medicine, Bronx, New York, USA
J Am Soc Nephrol 13:3005-15. 2002
- Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1David A Guertin
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Cambridge, Massachusetts 02141, USA
Dev Cell 11:859-71. 2006..Thus, mTORC1 function is essential in early development, mLST8 is required only for mTORC2 signaling, and mTORC2 is a necessary component of the Akt-FOXO and PKCalpha pathways...
- Crosstalk between small GTPases and polarity proteins in cell polarizationSandra Iden
Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
Nat Rev Mol Cell Biol 9:846-59. 2008..Recent findings provide insights into polarization mechanisms and show intriguing crosstalk between small GTPases and members of polarity complexes in regulating cell polarization in different cellular contexts and cell types...
- Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competenceJochen Guck
Institute for Soft Matter Physics, Department of Physics and Geosciences, University of Leipzig, 04103 Leipzig, Germany
Biophys J 88:3689-98. 2005..The cytoskeleton, an internal polymer network, in particular determines a cell's mechanical strength and morphology...
- Mechanotransduction - a field pulling together?Christopher S Chen
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
J Cell Sci 121:3285-92. 2008..through external forces that are applied to tissues or endogenous forces that are generated within the active cytoskeleton. Despite the wide array of studies demonstrating that such forces affect cellular signaling and function, it ..
- Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cellsB Wojciak-Stothard
Ludwig Institute for Cancer Research, London, United Kingdom
J Cell Physiol 176:150-65. 1998..Our data suggest that Cdc42, Rac, and Rho are activated in a hierarchical cascade following stimulation with TNF-alpha leading to actomyosin-mediated cell retraction and formation of intercellular gaps...
- Paxillin and focal adhesion signallingC E Turner
Department of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA
Nat Cell Biol 2:E231-6. 2000..Paxillin is a multi-domain adaptor found at the interface between the plasma membrane and the actin cytoskeleton. Here it provides a platform for the integration and processing of adhesion- and growth factor-related signals.
- Deconstructing the cadherin-catenin-actin complexSoichiro Yamada
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 123:889-901. 2005..extracellular domains of the cadherin family of adhesion proteins, and strengthened by linkage to the actin cytoskeleton. Prevailing dogma is that cadherins are linked to the actin cytoskeleton through beta-catenin and alpha-catenin,..
- Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channelsBenjamin D Matthews
Vascular Biology Program, Departments of Pathology and Surgery, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
J Cell Sci 119:508-18. 2006..Thus, cells use multiple mechanisms to sense and respond to static and dynamic changes in the level of mechanical stress applied to integrins...
- Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteinsZhanxiang Wang
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Cell Sci 122:893-903. 2009..Nearly 40 years ago, the actin cytoskeleton was first recognized as a key mediator of biphasic insulin release, and was originally presumed to act as a ..
- TGN golgins, Rabs and cytoskeleton: regulating the Golgi trafficking highwaysBruno Goud
Institut Curie, CNRS UMR144, 26, rue d Ulm, Paris cedex 75248, France
Trends Cell Biol 20:329-36. 2010..We explore the potential for TGN golgins, acting as scaffold molecules, to co-ordinate the regulation of TGN structure and function...
- The Wiskott-Aldrich syndrome: The actin cytoskeleton and immune cell functionMichael P Blundell
Molecular Immunology Unit, UCL Institute of Child Health, London, UK
Dis Markers 29:157-75. 2010..WASP is key in transducing signals from the cell surface to the actin cytoskeleton, and a lack of WASp results in cytoskeletal defects that compromise multiple aspects of normal cellular ..
- Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelopeZhaocai Zhou
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 287:5317-26. 2012..The LINC (linker of nucleoskeleton and cytoskeleton) complex, formed by the SUN and the nesprin proteins at the nuclear envelope, serves as a mechanical linkage ..
- Direct dynamin-actin interactions regulate the actin cytoskeletonChangkyu Gu
Nephrology Division, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Charlestown, MA 02129, USA
EMBO J 29:3593-606. 2010..Dynamin also regulates the actin cytoskeleton through an unknown, GTPase-dependent mechanism...
- Serum response factor: master regulator of the actin cytoskeleton and contractile apparatusJoseph M Miano
Cardiovascular Research Institute, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
Am J Physiol Cell Physiol 292:C70-81. 2007..and growth, these genetic studies point to a crucial role for SRF in cellular migration and normal actin cytoskeleton and contractile biology...
- alpha-Catenin as a tension transducer that induces adherens junction developmentShigenobu Yonemura
Electron Microscope Laboratory, RIKEN Center for Developmental Biology, Kobe, Hyogo 650 0047, Japan
Nat Cell Biol 12:533-42. 2010Adherens junctions (AJs), which are organized by adhesion proteins and the underlying actin cytoskeleton, probably sense pulling forces from adjacent cells and modulate opposing forces to maintain tissue integrity, but the regulatory ..
- IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusionsGiorgio Scita
IFOM FIRC Institute for Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy School of Medicine, University of Milan, 20122 Milan, Italy
Trends Cell Biol 18:52-60. 2008..Structural, biochemical and cell biological experiments support the unique role of this family as transducers of signalling, linking the protruding membrane to the underlying actin cytoskeleton.
- Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpressionMala V Rao
Center for Dementia Research, Nathan S Kline Institute, Orangeburg, New York 10962, USA
J Neurosci 28:12241-54. 2008..a novel hypothesis that CAST depletion by multiple abnormally activated proteases accelerates calpain dysregulation in AD leading to cytoskeleton disruption and neurodegeneration. CAST mimetics may, therefore, be neuroprotective in AD.
- Insights into mesenchymal stem cell aging: involvement of antioxidant defense and actin cytoskeletonGrit Kasper
Julius Wolff Institute and Center for Musculoskeletal Surgery Berlin, Charite Universitatsmedizin Berlin, Berlin, Germany
Stem Cells 27:1288-97. 2009..Functional annotation clustering revealed that age-affected molecular functions are associated with cytoskeleton organization and antioxidant defense...
- An actomyosin-based barrier inhibits cell mixing at compartmental boundaries in Drosophila embryosBruno Monier
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
Nat Cell Biol 12:60-5; sup pp 1-9. 2010..been proposed to explain compartmental cell sorting, mainly differential adhesion, but also regulation of the cytoskeleton or of cell proliferation...
- Microtubule actin cross-linking factor (MACF): a hybrid of dystonin and dystrophin that can interact with the actin and microtubule cytoskeletonsC L Leung
Department of Pathology and Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Cell Biol 147:1275-86. 1999..The properties of MACF are consistent with the observation that mutations in kakapo cause disorganization of microtubules in epidermal muscle attachment cells and some sensory neurons...
- Novel TIRF microscopy analyzing trafficking & signaling at the cell cortexDerek Toomre; Fiscal Year: 2009..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
- Mapping for Specialized Domains for FCeRI Signaling &InternalizationBridget S Wilson; Fiscal Year: 2013..Cytoskeletal elements, including actin-based corrals and cortical cytoskeleton networks, restrict receptor mobility and may also serve as tethers for protein islands...
- Gamma-Synuclein-Mediated Regulation of Norepinephrine TransporterAnita Sidhu; Fiscal Year: 2010..the function and trafficking of the NE transporter [NET], through interactions with the microtubule [MT] cytoskeleton. We show here that -Syn can also regulate these NET activities. Such modulation by -Syn is unique to NET...
- Regulation of B Cell Function by Membrane-Cytoskeletal RemodelingNeetu Gupta; Fiscal Year: 2012..Membrane remodeling requires membrane uncoupling from the underlying cortical cytoskeleton but its regulation and impact on B cell function is poorly understood...
- Investigating Mechanism of Intracellular Rotational Transport with Optical TJeffrey N Anker; Fiscal Year: 2012..for uptake, degradation and clearance of foreign particles, all biophysical processes which rely upon an intact cytoskeleton. Impairment of these biophysical processes due to nanoparticle-mediated cytoskeletal oxidation contributes to ..
- Maria Diakonova; Fiscal Year: 2014..protein-protein interactions, leading to the formation of a multiprotein complex that modulates the actin cytoskeleton, increases cell motility and invasiveness, mediates cyclin D1 gene transcription and affects tumorigenicity of ..
- Samuel D Crish; Fiscal Year: 2016..Specific aim 1 will examine changes in the cytoskeleton compared to two major risk factors in glaucoma: age (DBA/2J mice) and exposure to elevated intraocular pressure ..
- MARK L DELL'ACQUA; Fiscal Year: 2016..synapses, AMPA (AMPAR) and NMDA (NMDAR) glutamate receptors are linked to signaling proteins and the actin cytoskeleton in dendritic spines through a network of scaffolding proteins that play important roles during synaptic ..
- Subhash C Pandey; Fiscal Year: 2014..Third, the effector immediate-early gene Arc (activity- regulated cytoskeleton associated protein) may be relevant in regulating dendritic spine density (DSD) because it is rapidly induced ..
- Mary K Sheats; Fiscal Year: 2016..neutrophils coordinate chemoattractant signals in their external environment with reorganization of their actin cytoskeleton. The Myristolated Alanine-Rich C-Kinase Substrate (MARCKS) family of proteins, MARCKS and MARCKS-like 1 (..
- PATHOPHYSIOLOGY OF THE ENDOTHELIUMFrancis W Luscinskas; Fiscal Year: 2013..both of which involve coordinated interactions of cell-cell adhesion/junctional molecules and the actin cytoskeleton. Dysregulation of these endothelial functions promotes inflammatory disease processes...
- Identification of Proteins Important for Male OsteoporosisHong Wen Deng; Fiscal Year: 2013..problem is subcellular proteome extraction to stepwise isolate proteins from membrane, cytosol, nucleus, and cytoskeleton E fractions followed by sensitive 2D-nanoLC-ESI-MS/MS for fractioning and identifying significant proteins...
- FASEB SUMMER CONFERENCE ON PHOSPHOLIPASESAlex Brown; Fiscal Year: 2010..Phospholipase D generates phosphatidic acid from phosphatidylcholine, to regulate organization of the actin cytoskeleton, cell growth, survival, motility and vesicular transport...
- Interplay Between Tissue Architecture and Nuclear Organization in the DNA DamagePierre Alexandre Vidi; Fiscal Year: 2013..hypothesis will be tested with engineered hydrogels of defined stiffness, interference with the cytoskeleton dynamics, and uncoupling integrins from the cytoskeleton...
- Nuclear-Cytoplasmic Shuttling of Foxc2 via 14-3-3 Determines Proximal Tubule CellDIANA LYNNE GOLDEN; Fiscal Year: 2012..of Foxc2 localized to the cytoplasm will determine upregulation of Foxc2 on [unreadable]-actinin and cytoskeleton rearrangements...
- 4th ASM Conference on Prokaryotic Cell Biology and DevelopmentSusan S Golden; Fiscal Year: 2012..insights in our understanding of essential cell structures including the cell division apparatus, the cytoskeleton, the cell wall, and structures involved in bacterial motility...
- Subhash C Pandey; Fiscal Year: 2016..Our laboratory recently demonstrated that brain-derived neurotrophic factor (BDNF), activity-regulated cytoskeleton-associated protein (Arc) expression, and dendritic spine density (DSD) were lower in the central (CeA) and ..
- Christin Carter-Su; Fiscal Year: 2016..SH2B1 is recruited to JAK2 and is a critical component in GH regulation of the actin cytoskeleton, a prerequisite for cellular proliferation, differentiation and migration...
- RSK-2 regulates integrin-mediated adhesion and migrationJOE WILLIAM RAMOS; Fiscal Year: 2013..RSK2 modulates integrin function downstream of ERK by regulating integrin 2 tail interaction with the actin cytoskeleton. The research plan has three specific aims: (1) Establish the molecular mechanism by which RSK2 modulates ..
- Osteoclastic Protein-Tyrosine Phosphatase and ResorptionKin Hing William Lau; Fiscal Year: 2013..over-expression of EphA4 in wild-type precursors on the formation, fusion, adhesion, migration, actin cytoskeleton re-organization, and resorption activity of osteoclasts in vitro...
- Neuropilin and semaphorin, anti-angiogenesis activities and mechanismsMichael Klagsbrun; Fiscal Year: 2009..EC) and tumor cells characterized by inactivation of RhoA, loss of stress fibers, collapse of the F-actin cytoskeleton and inhibition of migration...
- MINORITY PREDOCTORAL FELLOWSHIP PROGRAMQuentin J Baca; Fiscal Year: 2010..There is biochemical evidence that populations of CD45 reside in lipid microdomains and associate with the cytoskeleton, and it is proposed that these interactions regulate CD45 function...
- Bruce S McEwen; Fiscal Year: 2015..activate genes related to oxidative stress and possibly inflammation and also alter neurotransmission and cytoskeleton. We plan to identify genes and gene products related to stress and GC effects by perturbing the endocannabinoid ..
- GARY ANDREW WEISMAN; Fiscal Year: 2016..Specific Aim 3 will determine whether P2Y2R interaction with the actin cytoskeleton regulates tight junction organization in Par-C10 monolayers...
- Identifying underlying mechanisms of intracellular changes in response to caregivMELANIE SARAH FLINT; Fiscal Year: 2013..T-cell migration is a complex, not yet well understood process;however it is known that a functional cytoskeleton and actin polymerization is essential...
- Fic-mediated AdenylylationCAROLYN ANN WORBY; Fiscal Year: 2013..Contrary to our expectations, we observed that the YopT-like domain of IbpA does not disrupt the actin cytoskeleton despite its conservation of the key catalytic C/H/D triad...
- Identifying Key Structural Elements in the Activation of the Arp2/3 ComplexPatricia A Khuu; Fiscal Year: 2013..complex fulfills in a key role in remodeling the actin filament network, a major component of the cellular cytoskeleton. The complex is essential for changes to cell shape associated with specific processes, such as endocytosis in ..
- Adhesion of Leptospira interrogans to Human Cell Surface ReceptorsJenifer L Coburn; Fiscal Year: 2010..endothelial cell monolayers, as revealed by microarray analyses of transcript levels, staining of the actin cytoskeleton, and rounding of the cells...
- In vivo analysis of the mechanisms of axon transport.Catherine M Drerup; Fiscal Year: 2011..kinase (Jnk) activity in cell culture, which could potentially have downstream effects on the microtubule cytoskeleton and cargo-motor binding...
- Ralph A Nixon; Fiscal Year: 2014..Defining the specific steps in this regulation will help to clarify mechanisms leading to major neurological diseases, including dementias, and will identify novel cellular targets for developing innovative therapies for these diseases. ..
- Rho-Modifying Cytotoxic Necrotizing Factor of E. coliALISON DAVIS O'BRIEN; Fiscal Year: 2013..These deamidation events trigger a myriad of effects on the target cells such as actin cytoskeleton rearrangements, cell cycle abnormalities, and alterations in signaling pathways...
- Identification of Mechanoresponsive Promoter Elements in ChondrogenesisDominik R Haudenschild; Fiscal Year: 2013..These approaches have successfully identi- fied integrins, focal adhesion complexes, the cytoskeleton, and select kinase pathways as me- diators of mechanotransduction...
- Enzymology of Chlamydia PathogenesisDewey G McCafferty; Fiscal Year: 2013..multivariable roles in modifying host or bacterial proteins involved in lipid and membrane transport, the actin cytoskeleton, microtubule-based motors, lysosomal recognition of the inclusion, ERK/MEK signaling pathways, and the onset of ..
- SIGNALING THROUGH RHO GTP/GDP EXCHANGE FACTORSPhilip B Wedegaertner; Fiscal Year: 2013..to dynamic cell architecture changes brought about by Rho's role in modifying a cell's actin cytoskeleton. Cellular processes under the control of Rho GTPases include smooth muscle cell contractility, cell adhesion, ..
- INSULIN ACTION IN MUSCLE AND FAT CELLSJAMES CARLTON GARRISON; Fiscal Year: 2010..mice, and mTORC2 is a newly discovered rapamycin-insensitive signaling complex that controls both the actin cytoskeleton and phosphorylation of Akt...
- Antigen receptor inputs: linking structural, molecular, and cellular responsesJonathan P Schneck; Fiscal Year: 2012..to affect T cell receptor clustering -glycosylation and the role of cholesterol and its interaction with the cytoskeleton. Second we will analyze the impact of genes identified in the screen in binding of a TCR ligand, soluble ..
- Functional analysis of mDia formins in hematopoietic stem cell engraftment and miPeng Ji; Fiscal Year: 2010..signaling pathways regulating HSC engraftment and migration often directly or indirectly target on the actin cytoskeleton network through proteins that regulate polymerization of the actin proteins...
- Warren G Hill; Fiscal Year: 2014..broad family of cell surface adhesion and signaling molecules which link the extracellular matrix (ECM) to the cytoskeleton of the cell...
- Mary C Beckerle; Fiscal Year: 2015DESCRIPTION (provided by applicant): The actin cytoskeleton is essential for cell viability and plays critical roles in cell shape, adhesion, and motility...
- Tengis S Pavlov; Fiscal Year: 2014..It is further hypothesized that increased H2O2 production results in changes of the actin cytoskeleton and that cortactin and MIM proteins are involved in this mechanism...
- Christopher E Turner; Fiscal Year: 2016..control of cell adhesion to the extracellular matrix (ECM) in coordination with remodeling of the actin cytoskeleton. The Rho family GTPases play a central role in this regulation but the mechanisms controlling the activity of ..
- HORMONAL REGULATION OF MESSENGER RNA STABILITYDaniel R Schoenberg; Fiscal Year: 2013..Consistent with this, PMR1 binds to the Ena/VASP proteins, which are regulators of the actin cytoskeleton, and cell motility is increased in cells ex- pressing catalytically-active PMR1...
- Laser Spinning Disc Confocal System for live-cell and live-organism microscopyMartha C Soto; Fiscal Year: 2012..C. elegans studies of the regulation of the actin cytoskeleton by the Extracellular Matrix during embryonic development in the Soto Lab are identifying new roles for axonal ..
- Role of the Tail Domain in Vinculin FunctionSharon L Campbell; Fiscal Year: 2010..Vinculin functions as a mechanical linker between transmembrane integrin receptors and the actin cytoskeleton through association with cell adhesion molecules...
- Dysfunction of neurofilaments in disease: an iPS model of Giant Axonal NeuropathyBETHANY LESLIE JOHNSON-KERNER; Fiscal Year: 2012..neurons and should inform our understanding the pathogenesis of GAN and other neurodegenerative diseases of the cytoskeleton. PUBLIC HEALTH RELEVANCE: In the autosomal recessive disease Giant Axonal Neuropathy (GAN), degeneration of ..
- K P CONNIE TAM; Fiscal Year: 2016..which are glycine-rich C-terminal fragments of keratin 6A, a major intermediate filament protein found in the cytoskeleton of a wide range of epithelial cells...
- MECHANISM OF RETROCORNEAL FIBROUS MEMBRANEEunDuck P Kay; Fiscal Year: 2010..We also showed that FGF-2 reorganizes actin cytoskeleton using Rho kinases (active Rac and Cdc42, and inactive Rho), thus generating a migratory cell phenotype...
- Mechanics and regulation of chromosome dynamics in meiotic prophaseMICHAEL EDWARD DRESSER; Fiscal Year: 2012..cerevisiae, telomeres connect across the nuclear envelope to elements of the actin cytoskeleton that drag the chromosomes along the nuclear periphery at rates up to ~2 5m/second...
- Subhash C Pandey; Fiscal Year: 2016..Several genes, such as brain-derived neurotrophic factor (BDNF), activity regulated cytoskeleton-associated (Arc) protein, and NMDA receptor subunits (NR2A&2B) are involved in regulating dendritic spine ..
- Fabeha Fazal; Fiscal Year: 2014..We previously showed that activation of RhoA/ROCK and the dynamic changes in actin cytoskeleton induced by thrombin are crucial for NF-(B activation and ICAM-1 expression...
- Encapsidation of the poxvirus genomePaula Traktman; Fiscal Year: 2012..As a result, the progression of the viral life cycle is intimately linked to interactions with the organelles, cytoskeleton and cytoplasmic milieu of the host cell...
- MARK A MC NIVEN; Fiscal Year: 2016..We have found that this contractile polymer associates with the actin cytoskeleton and specific adaptor proteins at both the PM to regulate receptor endocytosis and the TGN to mediate ..
- Signaling of Integrin Alpha 7Jianhua Luo; Fiscal Year: 2009..we also found that ILK, a serine/threonine kinase and structural protein associated with integrins and the cytoskeleton, bound and phosphorylated a tumor suppressor gene called myopodin, which regulates cell growth and cell ..
- Release of FGF1 and Pathology of AngiogenesisIgor Prudovsky; Fiscal Year: 2010..studies on liposomes and cell membrane vesicles, expression of specific regulators of the submembrane actin cytoskeleton will be used in Specific Aims 1 and 2...
- Role of Cofilin and Wnt Signaling in Neural Crest DevelopmentO apos NEIL WIGGAN; Fiscal Year: 2013Project Summary/Abstract Abstract: A key aspect of cell and tissue morphogenesis is regulation of the actin cytoskeleton. The actin cytoskeleton is a fundamental cellular scaffold which dictates cell morphology and multiple important ..
- Growth Hormone Regulation of SH2-B1Christin Carter Su; Fiscal Year: 2009..Independent of its ability to activate JAK2, SH2B1 enhances GH regulation of the actin cytoskeleton and cell motility. Finally, SH2B1 shuttles between the plasma membrane, cytoplasm and nucleus...
- Jianhua Luo; Fiscal Year: 2014..we also found that ILK, a serine/threonine kinase and structural protein associated with integrins and the cytoskeleton, bound and phosphorlyated a tumor suppressor gene called myopodin, which regulates cell growth and cell ..
- REGULATION OF CELLULAR RESPONSES TO NEUROPEPTIDESNigel W Bunnett; Fiscal Year: 2010..The role of the cytoskeleton and of endosomal acidification and phosphatases will be examined using specific drugs Aim 2 will define the ..
- Role of trabecular meshwork contractility in modulating outflow resistanceCHEE HIAN TAN; Fiscal Year: 2013..His specific cell biological focus was in cytoskeleton and cell- extracellular matrix interactions, with correlation to functional changes in live monkey hydrodynamic ..
- Rapid ischemic tolerance: Synaptic re-organization and reduced excitotoxicityRobert Meller; Fiscal Year: 2012..re-arrangement and synaptic reorganization leading to b) the disruption of NMDA receptor anchoring to the cytoskeleton, c) thus altering NMDA receptor function with resultant protection from harmful ischemia...
- Fengchun Ye; Fiscal Year: 2014..Previous studies suggest that lysine acetylation of cytoskeleton actins and microtubule plays important roles in viral entry and intracellular trafficking...
- Jinghua Hu; Fiscal Year: 2016..Small GTPases act as key molecular switches in diverse membrane- and cytoskeleton-related cellular processes. However, the roles of Arl family members are poorly defined...
- Modulation of Monocarboxylic Acid Transporter Kinetic Function for Stroke TherapyJEFFREY PAUL SMITH; Fiscal Year: 2010..This regulatory action is dependent upon dynamic changes in the Actin cytoskeleton which facilitates trafficking and serves as an anchor for the transducisome...
- Pathogen-host Interactions that Remodel the CytoskeletonTina Izard; Fiscal Year: 2010The deadly enteropathogen Shigella flexneri usurps components of the actin cytoskeleton for entry and movement in the host cell, and for the formation of protrusions used to infect neighboring cells...
- ACTININ ASSOCIATED LIM PROTEIN & FSH MUSCULAR DYSTROPHYDavid Bredt; Fiscal Year: 2002Disruptions of the myofiber cytoskeleton underlie several genetic muscular dystrophies, including Duchenne and Limb-girdle muscular dystrophies...
- Matrix-induced Myogenesis & Pharmaco-Screens of MSCsDennis Discher; Fiscal Year: 2009..interacts with chromatin and through linker proteins that span the envelope the lamina also interacts with the cytoskeleton. We have shown recently that the cytoskeleton is strongly influenced by matrix elasticity in acto-myosin ..
- Investigating the molecular and mechanical regulation of pulsed actomyosin contraADAM CHRISTOPHER MARTIN; Fiscal Year: 2010..Specifically, I gained much experience working with the actin cytoskeleton, which generates mechanical forces in cells...
- Molecular Function of Palladin's Ig Domains in Cell Adhesion and MotilityCarol A Otey; Fiscal Year: 2010..provided by applicant): Both cell-cell and cell-matrix adhesions require the participation of the actin cytoskeleton. Actin filaments are crosslinked into circumferential rings that are associated with cell-cell junctions and ..
- IGF-I PROTECTS NEURONS FROM GLUCOSE INDUCED CELL DEATHJames Russell; Fiscal Year: 2001..results in downstream phosphorylation of focal adhesion proteins involved in organization of the actin cytoskeleton and neurite formative, and 3) IGF-IR activation of phosphatidylinositol-3 kinase (PI-3K) is essential for ..
- Cytoskeletal organization in apicomplexan parasitesHeide Schatten; Fiscal Year: 2005..Despite the importance of the cytoskeleton for cell division in these unicellular organisms the mechanisms that power the separation of the genome remain ..
- PHOSPHOINOSITIDE REGULATION OF ERYTHROCYTE CYTOSKELETONRichard Andersen; Fiscal Year: 1991..The most clearly demonstrated "on-off" mechanism occurs in the red blood cell (RBC), where the cytoskeleton is attached to transmembrane receptors...
- Colloquium on the Cytoskeleton and Human DiseaseLeslie Wilson; Fiscal Year: 2001A broadly focused international research meeting on the cytoskeleton and its associated proteins in human diseases is planned from April 17 through April 20, 2001...