Genomes and Genes
viral inclusion bodies
Summary: An area showing altered staining behavior in the nucleus or cytoplasm of a virus-infected cell. Some inclusion bodies represent "virus factories" in which viral nucleic acid or protein is being synthesized; others are merely artifacts of fixation and staining. One example, Negri bodies, are found in the cytoplasm or processes of nerve cells in animals that have died from rabies.
Publications166 found, 100 shown here
- Mammalian reovirus nonstructural protein microNS forms large inclusions and colocalizes with reovirus microtubule-associated protein micro2 in transfected cellsTeresa J Broering
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
J Virol 76:8285-97. 2002..The capacity of microNS to form inclusions and to colocalize with micro2 in transfected cells suggests a key role for microNS in forming viral factories in reovirus-infected cells...
- Reovirus core protein mu2 determines the filamentous morphology of viral inclusion bodies by interacting with and stabilizing microtubulesJohn S L Parker
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
J Virol 76:4483-96. 2002..We conclude that the mu2 protein of most reovirus strains is a viral MAP and that it plays a key role in the formation and structural organization of reovirus inclusion bodies...
- Aggresomes and pericentriolar sites of virus assembly: cellular defense or viral design?Thomas Wileman
Infection and Immunity, School of Medicine, Faculty of Health, University of East Anglia, Norfolk NR4 7TJ, United Kingdom
Annu Rev Microbiol 61:149-67. 2007..Insights into the possible roles played by aggresomes during virus assembly are emerging from an understanding of how virus inclusions form and how viral proteins are targeted to them...
- Quantitative study of the infection in brain neurons in human rabiesA C Jackson
Department of Medicine, Queen s University, Kingston, Ontario, Canada K7L 2V7
J Med Virol 65:614-8. 2001..Formation of Negri bodies is likely influenced by factors that vary in different neuronal cell types...
- Immunohistochemical localization of endothelial and inducible nitric oxide synthase within neurons of cattle with rabiesTaekyun Shin
Department of Veterinary Medicine, Cheju National University, Jeju, Republic of Korea
J Vet Med Sci 66:539-41. 2004..The specific localization of eNOS, but not iNOS, in the Negri bodies suggests that eNOS is involved in the formation of rabies virus inclusion bodies...
- Interferon-induced alterations in the pattern of parainfluenza virus 5 transcription and protein synthesis and the induction of virus inclusion bodiesT S Carlos
School of Biology, University of St Andrews, Fife KY16 9TS, Scotland, United Kingdom
J Virol 79:14112-21. 2005....
- Immunohistopathology of calf pneumonia induced by endobronchial inoculation with bovine adenovirus 3M Narita
National Institute of Animal Health, Kamikita, Aomori, Japan
Vet Pathol 39:565-71. 2002..The difference in the immunopathologic reactions between the 1-week-old and the 3-month-old infected calves may be attributed to differences in immune system development...
- The YLDL sequence within Sendai virus M protein is critical for budding of virus-like particles and interacts with Alix/AIP1 independently of C proteinTakashi Irie
Department of Virology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Munami ku, Hiroshima 734 8551, Japan
J Virol 81:2263-73. 2007..Our results suggest that the interaction of multiple viral proteins with Alix/AIP1 may enhance the efficiency of the utilization of cellular MVB sorting machinery for efficient SeV budding...
- Identification of the orthopoxvirus p4c gene, which encodes a structural protein that directs intracellular mature virus particles into A-type inclusionsTerry A McKelvey
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Virol 76:11216-25. 2002..In this way, the P4c protein may affect both viral morphogenesis and processes of virus dissemination...
- FTA liver impressions as DNA template for detecting and genotyping fowl adenovirusHugo Moscoso
Poultry Diagnostic and Research Center, Department of Population Health, The University of Georgia, Athens, GA 30602 4875, USA
Avian Dis 51:118-21. 2007..Sequencing analysis showed that the viruses were EU serotypes 4, 5, 9, and 10. The results demonstrate that FTA filter paper inactivates the FAV I and maintains the DNA template for molecular analysis...
- Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complexDenise Egger
Institute for Medical Microbiology, University of Basel, CH 4003 Basel, Switzerland
J Virol 76:5974-84. 2002..Virchows Arch. B., 33:233-243, 1980). In view of this finding and the observation that all HCV proteins accumulate on the membranous web, we propose that the membranous web forms the viral replication complex in HCV-infected cells...
- Activation of cytomegalovirus in pig-to-primate organ xenotransplantationNicolas J Mueller
Infectious Diseases Division, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
J Virol 76:4734-40. 2002..The observation of graft injury by PCMV demonstrates that CMV will be an important pathogen in immunosuppressed xenograft recipients. Strategies must be developed to exclude CMV from porcine organ donors...
- Caveolin-1 is incorporated into mature respiratory syncytial virus particles during virus assembly on the surface of virus-infected cellsGaie Brown
MRC Virology Unit and Division of Virology, University of Glasgow, Institute of Virology, Church Street, Glasgow G11 5JR, UK
J Gen Virol 83:611-21. 2002..Collectively, these findings show that cav-1 is incorporated into the envelope of mature RSV particles during egress...
- A guide to viral inclusions, membrane rearrangements, factories, and viroplasm produced during virus replicationChristopher Netherton
Vaccinology Group, Pirbright Laboratories, Institute for Animal Health, Surrey, United Kingdom
Adv Virus Res 70:101-82. 2007....
- Prevention of inclusion body hepatitis/hydropericardium syndrome in progeny chickens by vaccination of breeders with fowl adenovirus and chicken anemia virusH Toro
Faculty of Veterinary Sciences, University Chile, Santiago
Avian Dis 46:547-54. 2002..FAV vaccination alone produced 24% HIB, similar to challenge strategy 2, demonstrating a lower protective effect...
- Intracytoplasmic inclusions in circulating leukocytes from an eastern box turtle (Terrapene carolina carolina) with iridoviral infectionMatthew C Allender
University of Illinois, College of Veterinary Medicine, 2001 South Lincoln Ave, Urbana, Illinois 61802, USA
J Wildl Dis 42:677-84. 2006....
- Cytomegalovirus co-infection in AIDS-associated oral Kaposi's sarcomaS Meer
Division of Oral Pathology, School of Oral Health Sciences, Private Bag 3, University of the Witwatersrand, Wits, 2050, Johannesburg, South Africa
Adv Dent Res 19:96-8. 2006..Nonetheless, it is vital that physicians be alerted to active CMV infection, so that timely intervention and careful observation can be instituted, ensuring early diagnosis and treatment...
- Ultrastructural characterization of SARS coronavirusCynthia S Goldsmith
Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 10:320-6. 2004..Electron microscopic studies were critical in identifying the etiologic agent of the SARS outbreak and in guiding subsequent laboratory and epidemiologic investigations...
- Reovirus nonstructural protein mu NS recruits viral core surface proteins and entering core particles to factory-like inclusionsTeresa J Broering
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
J Virol 78:1882-92. 2004..These findings expand a model for how viral and cellular components are recruited to the viral factories in infected cells and provide further evidence for the central but distinct roles of viral proteins mu NS and mu 2 in this process...
- Assembly of fluorescent chimeric virus-like particles of canine parvovirus in insect cellsL Gilbert
Department of Biological and Environmental Science, University of Jyvaskyla, P O Box 35, Jyvaskyla FIN 40014, Finland
Biochem Biophys Res Commun 313:878-87. 2004..In summary, we have developed fluorescent virus-like nanoparticles carrying a heterologous entity that can be utilized as a visualization tool to elucidate events related to a canine parvovirus infection...
- Highly efficient and economical baculovirus expression system for preparing human papillomavirus type16 virus-like particleJin Zheng
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Cancer Research, School of Life Science and Technology, Xi an Jiaotong University, Xi an 710061, China
Acta Biochim Biophys Sin (Shanghai) 36:548-52. 2004..Hopefully, the present expression and purification system is promising to be convenient, timesaving and economical for preparation of HPV16 VLP vaccine...
- Rice stripe virus 23.9 K protein aggregates and forms inclusion bodies in cultured insect cells and virus-infected plant cellsM Takahashi
National Institute for Agro Environmental Sciences, Tsukuba, Ibaraki, Japan
Arch Virol 148:2167-79. 2003..9 K protein antiserum were observed in virus-infected wheat tissue by electron microscopy. This paper thus demonstrates that RSV 23.9 K protein can aggregate in vivo and form inclusion bodies in infected plant tissue...
- Diagnostic and molecular evaluation of three iridovirus-associated salamander mortality eventsDouglas E Docherty
USGS, National Wildlife Health Center, 6006 Schroeder Road, Madison, Wisconsin 53711, USA
J Wildl Dis 39:556-66. 2003..Challenge assays are required to determine the fish and amphibian host range of these isolates and to assess the susceptibility of tiger and spotted salamanders to heterologous virus isolates...
- Productive infection of cerebellar granule cell neurons by JC virus in an HIV+ individualR A Du Pasquier
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Neurology 61:775-82. 2003..Sequence analysis of the JCV regulatory region from cerebellar virions showed a tandem repeat pattern also found in PML lesions of the frontal lobe WM...
- Ranavirus-associated morbidity and mortality in a group of captive eastern box turtles (Terrapene carolina carolina)Ryan De Voe
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
J Zoo Wildl Med 35:534-43. 2004..The virus was characterized by electron microscopy, polymerase chain reaction, and sequence analysis of a portion of the major capsid protein as a member of the genus Ranavirus...
- Complex intracellular inclusions in the brain of a child with a stealth virus encephalopathyW John Martin
Center for Complex Infectious Diseases, Rosemead, CA 91770, USA
Exp Mol Pathol 74:197-209. 2003..Many of the intracellular inclusions show highly ordered structuring, while others have a more amorphous appearance. These structures may provide a target for energy-based therapeutic intervention in stealth-virus-infected patients...
- Infection competition against grouper nervous necrosis virus by virus-like particles produced in Escherichia coliMing Wei Lu
Institute of Marine Resources 804, National Sun Yat Sen University, Kaohsiung, Taiwan
J Gen Virol 84:1577-82. 2003..The recombinant VLPs block attachment of native virus to the surface of cultured fish nerve cells, blocking infection by the native virus...
- Cytomegalovirus-associated pulmonary septal capillary injury sine inclusion body change: a distinctive cause of occult or macroscopic pulmonary hemorrhage in the immunocompetent hostCynthia Magro
Department of Pathology, Ohio State University, Columbus, Ohio 43210, USA
Appl Immunohistochem Mol Morphol 13:268-72. 2005....
- Spread of hepatitis B viruses in vitro requires extracellular progeny and may be codetermined by polarized egressA Funk
Department of General Virology, Heinrich Pette Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, 20251 Hamburg, Germany
J Virol 78:3977-83. 2004....
- Brome mosaic virus replicase proteins localize with the movement protein at infection-specific cytoplasmic inclusions in infected barley leaf cellsK Dohi
Laboratory of Plant Pathology, Graduate School of Agriculture, Kyoto University, Japan
Arch Virol 146:1607-15. 2001..The inclusions were oval or amorphous, and contained electron-lucent regions. Electron microscopic autoradiography showed that the inclusions were sites of [3H]uridine incorporation, suggesting that they are sites of viral RNA synthesis...
- Viral behavior of paracrystalline inclusions in osteoclasts of Paget's disease of boneS Abe
Department of Orthopedic Surgery, Teikyo University School of Medicine, Tokyo, Japan
Ultrastruct Pathol 19:455-61. 1995..These findings suggested that the inclusions showed viral behavior in pagetic osteoclasts, and that the nuclear modifications were caused by virus infection...
- Reovirus sigma NS and mu NS proteins form cytoplasmic inclusion structures in the absence of viral infectionMichelle M Becker
Department of Microbiology and Immunology and Elizabeth B Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Virol 77:5948-63. 2003..These data suggest that sigma NS and mu NS are the minimal viral components required to form inclusions, which then recruit other reovirus proteins and RNA to initiate viral genome replication...
- Iridovirus disease in two ornamental tropical freshwater fishes: African lampeye and dwarf gouramiChaiwud Sudthongkong
Faculty of Bioresources, Mie University, Tsu, Japan
Dis Aquat Organ 48:163-73. 2002..The nucleotide sequence of PCR products derived from ALIV (696 base pairs) and DGIV (701 base pairs) had 95.3% identity. These results indicate that ALIV and DGIV have a single origin...
- The hydropericardium syndrome in poultry--a current scenarioV Balamurugan
Division of Avian Diseases, Indian Veterinary Research Institute, Izatnagar, Bareilly, UP 243 122, India
Vet Res Commun 28:127-48. 2004..The vaccines are effective in the face of natural outbreaks or experimental challenge and significantly reduce the mortality...
- Inclusion body hepatitis as a primary disease in broilers in Saskatchewan, CanadaSusantha Gomis
Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5B4
Avian Dis 50:550-5. 2006....
- Vertical induction of the inclusion body hepatitis/hydropericardium syndrome with fowl adenovirus and chicken anemia virusH Toro
Faculty of Veterinary Sciences, University of Chile, Santiago
Avian Dis 45:215-22. 2001....
- Hydropericardium syndrome in Japanese quail (Coturnix coturnix japonica)P Roy
Central University Laboratory, Madras Veterinary College, Tamilnadu Veterinary and Animal Sciences University, Madhavaram Milk Colony, Chennai 600 051, India
Vet Rec 155:273-4. 2004
- Genetic characterization, pathogenicity, and protection studies with an avian adenovirus isolate associated with inclusion body hepatitisI R Alvarado
Department of Population Health, University of Georgia, Athens, GA 30602, USA
Avian Dis 51:27-32. 2007..We conclude that broiler-breeder progenies from 30- to 50-wk-old grandparents vaccinated with the AAV 8/11 vaccine were adequately protected against challenge with the AAV 8 and 11 serotypes and the Stanford strain...
- Genotyping of Canadian isolates of fowl adenovirusesDavor Ojkic
Animal Health Laboratory, University of Guelph, Guelph, Ontario, Canada
Avian Pathol 37:95-100. 2008..Co-infection rates in non-IBH submissions were 50.00% for infectious bursal disease virus, 40.70% for infectious bronchitis virus, 27.91% for reoviruses and 1.16% for Newcastle disease virus...
- Barley stripe mosaic virus-encoded proteins triple-gene block 2 and gammab localize to chloroplasts in virus-infected monocot and dicot plants, revealing hitherto-unknown roles in virus replicationL Torrance
Plant Pathology Programme, Scottish Crop Research Institute SCRI, Invergowrie, Dundee DD2 5DA, UK
J Gen Virol 87:2403-11. 2006..The results indicate that TGB2 and gammab proteins play a previously unknown functional role at the site of virus replication...
- Increased ubiquitination and other covariant phenotypes attributed to a strain- and temperature-dependent defect of reovirus core protein mu2Cathy L Miller
Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA
J Virol 78:10291-302. 2004..Because so few of the viral strains formed factories that were regularly associated with ubiquitinated proteins, we conclude that reovirus factories are generally distinct from cellular aggresomes...
- The spread of tobacco mosaic virus infection: insights into the cellular mechanism of RNA transportM Heinlein
Friedrich Miescher Institute, Basel, Switzerland
Cell Mol Life Sci 59:58-82. 2002..This review summarizes current knowledge of Tobacco mosaic virus infection with emphasis on the mechanism by which this virus targets its RNA genome from sites of replication to plasmodesmata to achieve intercellular spread...
- Purification and properties of the vaccinia virus mRNA processing factorSusan M D'Costa
Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida 32610 0266, USA
J Biol Chem 283:5267-75. 2008..In addition, we show that dephosphorylation of a cleavage competent extract with a nonspecific phosphatase abolishes cleavage activity implying a role for phosphorylation in cleavage activity...
- The uninvited guest: JC virus infection of neurons in PMLKenneth L Tyler
Neurology 61:734-5. 2003
- Complete unilateral ophthalmoplegia in herpes zoster ophthalmicusSrinivasan Sanjay
Department of Ophthalmology and Visual Sciences, Alexandra Hospital, Singapore
J Neuroophthalmol 29:325-37. 2009..cerebral circulation, as well as periaxial infarction in the optic nerve, pons, and medulla but without viral inclusion bodies or antigen...
- Usefulness of dead shrimp specimens in studying the epidemiology of white spot syndrome virus (WSSV) and chronic bacterial infectionC V Mohan
Department of Aquaculture, College of Fisheries, University of Agricultural Sciences, Mangalore, India
Dis Aquat Organ 50:1-8. 2002..Intranuclear viral inclusion bodies diagnostic of WSSV infection were detected in dead samples from 32 ponds (64 %)...
- Respiratory syncytial virus induces host RNA stress granules to facilitate viral replicationMichael E Lindquist
Departments of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2905, USA
J Virol 84:12274-84. 2010..We also showed that stress granules are distinct from cytoplasmic viral inclusion bodies and that the RNA binding protein HuR, normally found in stress granules, also localized to viral inclusion ..
- Host factor Ebp1 inhibits rinderpest virus transcription in vivoM Gopinath
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India
Arch Virol 155:455-62. 2010..Ebp1 protein has been shown to co-localize with viral inclusion bodies in infected cells, and it is packaged into virions, presumably through its interaction with the N protein ..
- [Ultrastructural observation of rat thymus tissue with coronavirus infection]Ying jie Piao
Department of Histology and Embryology, First Military Medical University, Guangzhou 510515, China
Di Yi Jun Yi Da Xue Xue Bao 23:414-5, 420. 2003..To investigate the ultrastructure of rat thymus tissues with rat coronavirus (RCV) infection for clarifying the mechanism responsible for the morphological changes of the cells infected by RCV...
- Nucleocapsid formation and/or subsequent conformational change of rabies virus nucleoprotein (N) is a prerequisite step for acquiring the phosphatase-sensitive epitope of monoclonal antibody 5-2-26A Kawai
Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Sakyo ku, 606 8501, Japan
Virology 263:395-407. 1999..mutant N proteins were shown to be similarly accumulated as the wild-type N proteins into the viral inclusion bodies, defined as the virus-specific structures composed of viral nucleocapsids, that are produced in the ..
- Polyomavirus nephropathy in native kidneys and renal allografts: an update on an escalating threatVolker Nickeleit
Nephropathology Laboratory, Department of Pathology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
Transpl Int 19:960-73. 2006..BKN is morphologically defined by the presence of intranuclear viral inclusion bodies in epithelial cells and tubular injury, which is the morphological correlate for renal dysfunction...
- YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoterPer S Holm
Institut für Experimentelle Onkologie und Therapieforschung, Technische Universitat Munchen, Klinikum rechts der Isar, Munchen 81675, Germany
J Biol Chem 277:10427-34. 2002..transcription factor YB-1 to the nuclei of adenovirus type 5-infected cells where it is associated with viral inclusion bodies believed to be sites of viral transcription and replication...
- Clinical, histologic, and immunohistochemical characterization of wart-like lesions on the paw pads of dogs: 24 cases (2000-2007)Jason M Balara
Department of Veterinary Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA
J Am Vet Med Assoc 234:1555-8. 2009..biopsy specimens (n = 11) were submitted for immunohistochemical staining and a PCR assay to identify viral inclusion bodies. RESULTS- In Greyhounds, most lesions involved the pads of the third and fourth digits, had a consistent ..
- Parvovirus B19: a pathogen responsible for more than hematologic disordersBurkhard D Bültmann
Institute of Pathology, University of Tubingen, Liebermeisterstrasse 8, D 72076 Tubingen, Germany
Virchows Arch 442:8-17. 2003..lytic infections occurring in transient aplastic anemia or nonimmune hydrops fetalis by the detection of viral inclusion bodies in erythroid precursor cells...
- Mortality due to polyomavirus infection in two nightjars (Caprimulgus europaeus)Ana Sofia Arroube
Veterinary Faculty, Evora University, Portugal
J Avian Med Surg 23:136-40. 2009..On histologic examination, intranuclear viral inclusion bodies consistent with avian polyomavirus were observed in the liver, spleen, and kidneys...
- Interferon-induced inhibition of parainfluenza virus type 5; the roles of MxA, PKR and oligo A synthetase/RNase LT S Carlos
School of Biology, University of St Andrews, Fife KY16 9ST, Scotland, UK
Virology 363:166-73. 2007..treatment also caused a rapid redistribution of virus proteins and enhanced the formation of cytoplasmic viral inclusion bodies. The most studied IFN-induced genes with known anti-viral activity are MxA, PKR and the Oligo A synthetase/..
- Presence of occult cytomegalovirus infection in the brain after orthotopic liver transplantation. An autopsy study of 83 casesTeresa Ribalta
Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona Medical School, Spain
Virchows Arch 440:166-71. 2002..6%), and in 5 controls (13.8%) (P=0.00017). Viral inclusion bodies, inflammatory infiltrates, or necrotizing changes were not identified in any case...
- Fatal disseminated adenoviral infection associated with thrombotic thrombocytopenic purpura after allogeneic bone marrow transplantationA B Fassas
Department of Medicine, Greenebaum Cancer Center, University of Maryland, Baltimore, USA
Leuk Lymphoma 42:801-4. 2001..Liver biopsy showed parenchymal necrosis with intranuclear viral inclusion bodies. Immunohistochemistry was positive for adenovirus...
- Expression of the rice hoja blanca virus (RHBV) non-structural protein 3 (NS3) in Escherichia coli and its in situ localization in RHBV-infected rice tissuesMiguel Munoz
Centro de Investigacion en Biologia Celular y Molecular, Universidad de Costa Rica
Rev Biol Trop 52:765-75. 2004..viral nucleocapsid protein revealed in situ accumulation of NS3 protein in the cytoplasm but not in the viral inclusion bodies, vacuoles or chloroplasts of RHBV-infected plants, following the same pattern of distribution as the RHBV ..
- The molecular organization of cypovirus polyhedraFasseli Coulibaly
School of Biological Sciences, University of Auckland, 1010, New Zealand
Nature 446:97-101. 2007..The structure suggests that polyhedra can serve as the basis for the development of robust and versatile nanoparticles for biotechnological applications such as microarrays and biopesticides...
- Viruses as agents of disease. 1948Thomas Francis
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:S17-21. 2005
- Cytomegalovirus infection of the upper gastrointestinal tract: a clinical and pathological study of 30 casesLuca Reggiani Bonetti
Section of Pathologic Anatomy, Azienda Ospedaliera Universitaria, Policlinico, Modena, Italy
Scand J Gastroenterol 46:1228-35. 2011..The study reviews the endoscopic and histological features of human cytomegalovirus (HCMV) infections of the upper gastrointestinal (UGI) tract...
- Detection of infectious myonecrosis virus in penaeid shrimps using immunoassays: usefulness of monoclonal antibodies directed to the viral major capsid proteinMariana Borsa
Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina, UFSC, Florianopolis, Brazil
Arch Virol 156:9-16. 2011..a ~100-kDa protein, which corresponds to the predicted mass of the IMNV major capsid protein, as well as viral inclusion bodies in muscle fibroses by western blot and immunohistochemistry...
- Columbid herpesvirus-1 in two Cooper's hawks (Accipiter cooperii) with fatal inclusion body diseaseMarie E Pinkerton
Veterinary Diagnostic Laboratory and Department of Pathobiology, College of Veterinary Medicine, University of Illinois, 2001 South Lincoln Avenue, Urbana, IL 61802, USA
J Wildl Dis 44:622-8. 2008..PCR results provide evidence that this disease is transmitted to raptors via Rock Pigeons, most likely through ingestion of Rock Pigeons as prey...
- Congenital cytomegalovirus infection: a cause of renal dysplasia?Maren Chan
Department of Pathology at Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Pediatr Dev Pathol 10:300-4. 2007..Herein, we describe a case of unilateral renal dysplasia in a 19-week fetus with concurrent CMV infection. We believe the present case to be the first description of a virus apparently inducing renal multicystic dysplasia...
- Avian polyomavirus infection of a fledgling budgerigar (Melopsittacus undulatus) and differential diagnoses of viral inclusions in psittacine birds--case report and mini-reviewVanessa Herder
Department of Pathology, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany
Berl Munch Tierarztl Wochenschr 124:209-16. 2011..on fresh skin samples was negative whereas on formalin-fixed kidney samples with a high amount of viral inclusion bodies yielded a positive result...
- [Clinical features of severe intestinal graft-versus-host disease in 34 cases following allogeneic hematopoietic stem cell transplantation]Rong Mu Luo
Department of Hematopoietic Stem Cell Transplantation, Beijing Dao pei Hospital, Beijing, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 19:1501-4. 2011..The deep ulcers could be found under colonoscope. Histopathologic examination revealed the viral inclusion bodies or positive viral antigen...
- Non-permissive C6/36 cell culture for the Australian isolate of Macrobrachium rosenbergii nodavirusO Hayakijkosol
School of Veterinary and Biomedical Sciences, James Cook University, QLD, Australia
J Fish Dis 36:401-9. 2013..Typical cytopathic effects such as vacuolation and viral inclusion bodies were observed in infected C6/36 cells with H&E and Giemsa staining...
- Novel polyomaviral infection in the placenta of a northern fur seal (Callorhinus ursinus) on the Pribilof Islands, Alaska, USAColleen Duncan
Colorado State University Veterinary Diagnostic Laboratory, 300 West Drake Ave, Fort Collins, Colorado 80523, USA
J Wildl Dis 49:163-7. 2013..In 2010, intranuclear viral inclusion bodies were identified in trophoblasts of a single northern fur seal (NFS; Callorhinus ursinus) placenta from a ..
- Direct evidence for a chronic CD8+-T-cell-mediated immune reaction to tax within the muscle of a human T-cell leukemia/lymphoma virus type 1-infected patient with sporadic inclusion body myositisSimona Ozden
Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Paris, France
J Virol 78:10320-7. 2004....
- Autographa californica multiple nucleopolyhedrovirus ac66 is required for the efficient egress of nucleocapsids from the nucleus, general synthesis of preoccluded virions and occlusion body formationJianhao Ke
State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen University, 510275 Guangzhou, China
Virology 374:421-31. 2008..These results suggested that ac66 plays an important role for the efficient exit of nucleocapsids from the nucleus to the cytoplasm for BV synthesis as well as for preoccluded virion and occlusion synthesis...
- The respiratory syncytial virus fusion protein targets to the perimeter of inclusion bodies and facilitates filament formation by a cytoplasmic tail-dependent mechanismPradyumna S Baviskar
Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma, USA
J Virol 87:10730-41. 2013..in CT-R2 but not CT-R1 led to accumulation of M and F proteins within and at the perimeter of viral inclusion bodies (IBs), respectively...
- Nuclear import of CaMV P6 is required for infection and suppression of the RNA silencing factor DRB4Gabrielle Haas
Institut de Biologie Moleculaire des Plantes, CNRS UPR2353, Universite Louis Pasteur, Strasbourg, France
EMBO J 27:2102-12. 2008..This study identifies both genetic and physical interactions between a VSR to a host RNA silencing component, and highlights the importance of subcellular compartmentalization in VSR function...
- High and compact formation of baculoviral polyhedrin-induced inclusion body by co-expression of baculoviral FP25 in Escherichia coliLin Li
Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790 784, Korea
Biotechnol Bioeng 96:1183-90. 2007..Therefore, co-expression of baculoviral FP25 can be promisingly used to increase the levels of baculoviral Polh-fused foreign proteins, especially harmful proteins, expressed as inclusion bodies in an E. coli expression system...
- Characterization of fowl adenoviruses isolated in Ontario and Quebec, CanadaDavor Ojkic
Animal Health Laboratory, Laboratory Services Division, University of Guelph, Guelph, Ontario NIG 2W1
Can J Vet Res 72:236-41. 2008..The number of serotype 8 virus isolations has increased over the years, and by 2001 serotype 8 had become the dominant serotype in Ontario, and continues to be so. Moreover, this virus (FAdV-8) has shown a strong association with IBH...
- Clinicopathological and ultrastructural study of multiple lobular capillary hemangioma after scaldingWen Jun Liao
Center of Dermatology of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi an, China
Dermatology 213:34-6. 2006..Ultrastructural examination revealed features typical of a lobular capillary hemangioma and viral inclusion bodies in the epidermis of case 1. Multiple lobular capillary hemangiomas after scalding are rarely reported...
- Bombyx mori nucleopolyhedrovirus SNF2 global transactivator homologue (Bm33) enhances viral pathogenicity in B. mori larvaeSusumu Katsuma
Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
J Gen Virol 89:3039-46. 2008..mori larvae when tested by either BV injection or OB ingestion. These results suggest that Bm33 is not essential for virus growth in vitro or in vivo, but that it accelerates the time of death of B. mori larvae...
- Refolding, crystallization and preliminary X-ray structural studies of the West Nile virus envelope (E) protein domain IIIFang Yuan
Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford University, Oxford OX3 9DU, England
Acta Crystallogr Sect F Struct Biol Cryst Commun 61:421-3. 2005..The crystals belong to space group P222(1), with unit-cell parameters a = 52.6, b = 59.7, c = 95.0 A. A complete data set was collected to 2.8 A at 100 K with Cu Kalpha X-rays from a rotating-anode generator...
- Detection and localization of Rice stripe virus gene products in vivoDelin Liang
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, HMR 400, 2011 Zonal Ave, Los Angeles, CA 90033, USA
Virus Genes 31:211-21. 2005..Our results confirm the in vivo ambisense coding strategy of Tenuivirus RNA 2 and provide further evidence that RSV does not produce enveloped virions in infected rice plants...
- Combined distemper-adenoviral pneumonia in a dogLuis E Rodriguez-Tovar
Departamento de Patologia, Facultad de Medicina Veterinaria y Zootecnia, UANL, Avenida Lázaro Cárdenas 4600 pte, Unidad Universitaria Mederos, Monterrey, N L CP 64930, Mexico
Can Vet J 48:632-4. 2007..Presence of both viruses was confirmed via immunohistochemical staining...
- Recurrent cytomegalovirus colitis with megacolon in an immunocompetent elderly manYi Hsuan Lin
Division of Digestive Therapeutic Endoscopy, Department of Gastroenterology, Chang Gung Memorial Hospital, Linkou Medical Center, Tao Yuan, Taiwan
J Med Virol 82:638-41. 2010..Colitis caused by CMV colitis should be considered in elderly people with diarrhea...
- Insecticidal properties and microbial contaminants in a Spodoptera exigua multiple nucleopolyhedrovirus (Baculoviridae) formulation stored at different temperaturesRodrigo Lasa
Departamento de Producción Agraria, Universidad Publica de Navarra, Pamplona 31006, Spain
J Econ Entomol 101:42-9. 2008..We conclude that OB formulation with bacteriostatic or antioxidant additives, together with storage and distribution in refrigerated conditions, will likely result in an SeMNPV biopesticide shelf life that exceeds 18 mo...
- Isolation of etiological agent of hydropericardium syndrome in chicken embryo liver cell culture and its serological characterizationRajesh Kumar
Department of Veterinary Microbiology, College of Veterinary Sciences, G B Pant University of Agriculture and Technology, Pantnagar 263 145
Indian J Exp Biol 41:821-6. 2003....
- Partial characterization of retroviruses from boid snakes with inclusion body diseaseE R Jacobson
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA
Am J Vet Res 62:217-24. 2001..Whether this virus represents the causative agent of IBD is yet to be determined. The isolation of retroviruses from boid snakes with IBD is an important step n the process of identifying the causative agent of this disease...
- Detection of porcine circovirus 2 (PCV-2) DNA by nested PCR from formalin-fixed tissues of post-weaning multisystemic wasting syndrome (PMWS) pigs in ThailandWijit Kiatipattanasakul-Banlunara
Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand
J Vet Med Sci 64:449-52. 2002..Histopathology showed characteristic lesions of PMWS and intracytoplasmic viral inclusion bodies in macrophages infiltrating in lymphoid tissues...
- Gastrointestinal pathogenicity of adenoviruses and reoviruses isolated from broiler chickens in AlabamaS D Lenz
Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849 5519, USA
J Vet Diagn Invest 10:145-51. 1998..Intranuclear viral inclusion bodies occurred in gizzard epithelium and pancreatic acinar cells at the sites of lesions...
- Nucleic acid-binding properties and subcellular localization of the 3a protein of brome mosaic bromovirusM Fujita
Laboratory of Plant Pathology, Graduate School of Agriculture, Kyoto University, Japan
J Gen Virol 79:1273-80. 1998..Immunogold labelling of thin sections of infected barley tissues revealed that B3a was associated with plasmodesmata and cytoplasmic inclusions...
- Serological association between spirorchidiasis, herpesvirus infection, and fibropapillomatosis in green turtles from FloridaL H Herbst
Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA
J Wildl Dis 34:496-507. 1998..The strong association between antibody reactivity to herpesvirus antigens and GTFP status in both captive-reared and free-ranging turtles is consistent with the hypothesis that the transmissible agent that causes GTFP is a herpesvirus...
- A novel immunohistochemical assay for the detection of Ebola virus in skin: implications for diagnosis, spread, and surveillance of Ebola hemorrhagic fever. Commission de Lutte contre les Epidémies à KikwitS R Zaki
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Infect Dis 179:S36-47. 1999..IHC testing of formalin-fixed skin specimens is a safe, sensitive, and specific method for laboratory diagnosis of EHF and should be useful for EHF surveillance and prevention...
- Cytomegalovirus-induced necrotizing and crescentic glomerulonephritis in a renal transplant patientR K Detwiler
Department of Pathology, East Carolina University School of Medicine, Greenville, NC 27858, USA
Am J Kidney Dis 32:820-4. 1998..This case represents the first report of CMV-associated NCGN in a renal transplant patient...
- Relapsing herpes simplex encephalitis: pathological confirmation of viral reactivationS Yamada
Department of Neurology, Gifu Prefectural Tajimi Hospital, Gifu, Japan
J Neurol Neurosurg Psychiatry 74:262-4. 2003..This is the first case report demonstrating HSV-1 antigen, HSV-1 DNA, and herpes simplex virus nucleocapsids in a case of relapsing herpes simplex encephalitis...
- Renal allograft dysfunction associated with cytomegalovirus infectionM J Shaver
Division of Nephrology and Department of Pathology at the University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
Am J Kidney Dis 34:942-6. 1999..Further studies are needed to establish the mechanism of allograft dysfunction in the absence of inflammatory changes...
- Experimental infection of lacertids with lizard erythrocytic virusesAntónio Pedro Alves de Matos
Anatomic Pathology Department, Electron Microscopy Unit, Curry Cabral Hospital, Lisbon, Portugal
Intervirology 45:150-9. 2002..This work reports on an experimental study of the infection process in Lacerta monticola and Lacerta schreiberi from Serra da Estrela Mountain, Portugal...
- Pathogenesis of experimental Ebola Zaire virus infection in BALB/c miceT R Gibb
Diagnostic Systems, United States Army Medical Research Institute of Infectious Diseases (USAMRIID, Fort Detrick, Frederick, Maryland 21702-5011, USA
J Comp Pathol 125:233-42. 2001..The availability of immunodeficient, "gene-knockout" and transgenic mice will make the mouse model particularly useful for studying the early steps of Ebola pathogenesis...
- Reovirus sigma NS protein localizes to inclusions through an association requiring the mu NS amino terminusCathy L Miller
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
J Virol 77:4566-76. 2003..The results of this study provide further evidence that mu NS plays a key role in forming the reovirus factories and recruiting other components to them...
- Overcoming inclusion body formation in a high-level expression systemJ T Moore
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany
Protein Expr Purif 4:160-3. 1993..The use of a rich growth medium during the course of protein induction may be a valuable adjunct to limiting inclusion body formation with this as well as other expression systems...
- The clinical pathology of severe acute respiratory syndrome (SARS): a report from ChinaYanqing Ding
Department of Pathology, Nan Fang Hospital, First Military Medical University, Guangzhou, Guangdong Province 510515, PR China
J Pathol 200:282-9. 2003..of protein and monocytes, lymphocytes and plasma cells in alveoli, hyaline membrane formation, and viral inclusion bodies in alveolar epithelial cells...
- Molluscum contagiosum in an immune reconstituted AIDS patientT Albini
Br J Ophthalmol 87:1427-8. 2003
- [Changes in ultrastructure and protein metabolism of tobacco plants infected by tomato spotted wilt virus]O H Kovalenko
Tsitol Genet 37:24-9. 2003..At the same time it induces formation of at least three pathogenesis-associated proteins (PR-proteins) and two antiviral factors of the types AVF (6) and IVR (7) active towards tobacco mosaic virus...
- Identification of cytomegalovirus in a liquid-based gynecologic sample using morphology, immunohistochemistry, and DNA real-time PCR detectionHarmanjatinder S Sekhon
Division of Cytopathology and Division of Molecular Diagnostics, Department of Pathology, Oregon Health and Sciences University, Portland, Oregon 97201, USA
Diagn Cytopathol 30:411-7. 2004..These observations suggest that a liquid-based preparation can be used to assess CMV infection morphologically, immunohistochemically, and by real-time PCR...
- [Study on etiology and pathology of severe acute respiratory syndrome]Yan qing Ding
Department of Pathology, Nanfang Hospital, The First Military Medical University, Guangzhou 510515, China
Zhonghua Bing Li Xue Za Zhi 32:195-200. 2003..To investigate the clinicopathologic characteristics of severe acute respiratory syndrome (SARS)...
- Viral inclusion bodies and aggresomes: form and functionJohn Parker; Fiscal Year: 2004..This research should significantly advance our understanding of how cytopathology and disease are induced during viral and neurodegenerative disease by the formation of intracellular inclusion bodies. ..
- MEASLES VACCINES--IMMUNE RESPONSES AND ATYPICAL MEASLESDiane Griffin; Fiscal Year: 2001....
- Immune Responses During Measles Virus InfectionDiane Griffin; Fiscal Year: 2007..3. To determine the roles of different CD4 and CD8 T cell populations in production of cytokines at various times during measles and the effect of concurrent HIV infection on these roles. ..
- 2007 Viruses & Cells Gordon ConferenceDiane Griffin; Fiscal Year: 2007..abstract_text> ..
- Infectious Diseases of the Nervous System: Pathogenesis and Worldwide ImpactDiane Griffin; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- ACUTE ALPHAVIRAL ENCEPHALITISDiane Griffin; Fiscal Year: 2008..abstract_text> ..
- Experimental Creutzfeldt Jacob DiseaseLaura Manuelidis; Fiscal Year: 2007..Rapid infectivity assays in vitro can open the study of TSEs by providing a way to test any pure molecule or structure for its intrinsic infectivity by Koch's established postulates for infectious pathogens. ..
- Role of Polyamines in MYCN-Amplified NeuroblastomaANDRE BACHMANN; Fiscal Year: 2009..Our research will be useful in the development of novel treatments for the most aggressive forms of the childhood cancer neuroblastoma. ..