viral inclusion bodies

Summary

Summary: An area showing altered staining behavior in the nucleus or cytoplasm of a virus-infected cell. Some inclusion bodies represent "virus factories" in which viral nucleic acid or protein is being synthesized; others are merely artifacts of fixation and staining. One example, Negri bodies, are found in the cytoplasm or processes of nerve cells in animals that have died from rabies.

Top Publications

  1. pmc Mammalian reovirus nonstructural protein microNS forms large inclusions and colocalizes with reovirus microtubule-associated protein micro2 in transfected cells
    Teresa J Broering
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 76:8285-97. 2002
  2. pmc Reovirus core protein mu2 determines the filamentous morphology of viral inclusion bodies by interacting with and stabilizing microtubules
    John S L Parker
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 76:4483-96. 2002
  3. ncbi Aggresomes and pericentriolar sites of virus assembly: cellular defense or viral design?
    Thomas Wileman
    Infection and Immunity, School of Medicine, Faculty of Health, University of East Anglia, Norfolk NR4 7TJ, United Kingdom
    Annu Rev Microbiol 61:149-67. 2007
  4. ncbi Quantitative study of the infection in brain neurons in human rabies
    A C Jackson
    Department of Medicine, Queen s University, Kingston, Ontario, Canada K7L 2V7
    J Med Virol 65:614-8. 2001
  5. ncbi Immunohistochemical localization of endothelial and inducible nitric oxide synthase within neurons of cattle with rabies
    Taekyun Shin
    Department of Veterinary Medicine, Cheju National University, Jeju, Republic of Korea
    J Vet Med Sci 66:539-41. 2004
  6. pmc Interferon-induced alterations in the pattern of parainfluenza virus 5 transcription and protein synthesis and the induction of virus inclusion bodies
    T S Carlos
    School of Biology, University of St Andrews, Fife KY16 9TS, Scotland, United Kingdom
    J Virol 79:14112-21. 2005
  7. ncbi Immunohistopathology of calf pneumonia induced by endobronchial inoculation with bovine adenovirus 3
    M Narita
    National Institute of Animal Health, Kamikita, Aomori, Japan
    Vet Pathol 39:565-71. 2002
  8. pmc The YLDL sequence within Sendai virus M protein is critical for budding of virus-like particles and interacts with Alix/AIP1 independently of C protein
    Takashi Irie
    Department of Virology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Munami ku, Hiroshima 734 8551, Japan
    J Virol 81:2263-73. 2007
  9. pmc Identification of the orthopoxvirus p4c gene, which encodes a structural protein that directs intracellular mature virus particles into A-type inclusions
    Terry A McKelvey
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Virol 76:11216-25. 2002
  10. ncbi FTA liver impressions as DNA template for detecting and genotyping fowl adenovirus
    Hugo Moscoso
    Poultry Diagnostic and Research Center, Department of Population Health, The University of Georgia, Athens, GA 30602 4875, USA
    Avian Dis 51:118-21. 2007

Research Grants

Detail Information

Publications166 found, 100 shown here

  1. pmc Mammalian reovirus nonstructural protein microNS forms large inclusions and colocalizes with reovirus microtubule-associated protein micro2 in transfected cells
    Teresa J Broering
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 76:8285-97. 2002
    ..The capacity of microNS to form inclusions and to colocalize with micro2 in transfected cells suggests a key role for microNS in forming viral factories in reovirus-infected cells...
  2. pmc Reovirus core protein mu2 determines the filamentous morphology of viral inclusion bodies by interacting with and stabilizing microtubules
    John S L Parker
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 76:4483-96. 2002
    ..We conclude that the mu2 protein of most reovirus strains is a viral MAP and that it plays a key role in the formation and structural organization of reovirus inclusion bodies...
  3. ncbi Aggresomes and pericentriolar sites of virus assembly: cellular defense or viral design?
    Thomas Wileman
    Infection and Immunity, School of Medicine, Faculty of Health, University of East Anglia, Norfolk NR4 7TJ, United Kingdom
    Annu Rev Microbiol 61:149-67. 2007
    ..Insights into the possible roles played by aggresomes during virus assembly are emerging from an understanding of how virus inclusions form and how viral proteins are targeted to them...
  4. ncbi Quantitative study of the infection in brain neurons in human rabies
    A C Jackson
    Department of Medicine, Queen s University, Kingston, Ontario, Canada K7L 2V7
    J Med Virol 65:614-8. 2001
    ..Formation of Negri bodies is likely influenced by factors that vary in different neuronal cell types...
  5. ncbi Immunohistochemical localization of endothelial and inducible nitric oxide synthase within neurons of cattle with rabies
    Taekyun Shin
    Department of Veterinary Medicine, Cheju National University, Jeju, Republic of Korea
    J Vet Med Sci 66:539-41. 2004
    ..The specific localization of eNOS, but not iNOS, in the Negri bodies suggests that eNOS is involved in the formation of rabies virus inclusion bodies...
  6. pmc Interferon-induced alterations in the pattern of parainfluenza virus 5 transcription and protein synthesis and the induction of virus inclusion bodies
    T S Carlos
    School of Biology, University of St Andrews, Fife KY16 9TS, Scotland, United Kingdom
    J Virol 79:14112-21. 2005
    ....
  7. ncbi Immunohistopathology of calf pneumonia induced by endobronchial inoculation with bovine adenovirus 3
    M Narita
    National Institute of Animal Health, Kamikita, Aomori, Japan
    Vet Pathol 39:565-71. 2002
    ..The difference in the immunopathologic reactions between the 1-week-old and the 3-month-old infected calves may be attributed to differences in immune system development...
  8. pmc The YLDL sequence within Sendai virus M protein is critical for budding of virus-like particles and interacts with Alix/AIP1 independently of C protein
    Takashi Irie
    Department of Virology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Munami ku, Hiroshima 734 8551, Japan
    J Virol 81:2263-73. 2007
    ..Our results suggest that the interaction of multiple viral proteins with Alix/AIP1 may enhance the efficiency of the utilization of cellular MVB sorting machinery for efficient SeV budding...
  9. pmc Identification of the orthopoxvirus p4c gene, which encodes a structural protein that directs intracellular mature virus particles into A-type inclusions
    Terry A McKelvey
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Virol 76:11216-25. 2002
    ..In this way, the P4c protein may affect both viral morphogenesis and processes of virus dissemination...
  10. ncbi FTA liver impressions as DNA template for detecting and genotyping fowl adenovirus
    Hugo Moscoso
    Poultry Diagnostic and Research Center, Department of Population Health, The University of Georgia, Athens, GA 30602 4875, USA
    Avian Dis 51:118-21. 2007
    ..Sequencing analysis showed that the viruses were EU serotypes 4, 5, 9, and 10. The results demonstrate that FTA filter paper inactivates the FAV I and maintains the DNA template for molecular analysis...
  11. pmc Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex
    Denise Egger
    Institute for Medical Microbiology, University of Basel, CH 4003 Basel, Switzerland
    J Virol 76:5974-84. 2002
    ..Virchows Arch. B., 33:233-243, 1980). In view of this finding and the observation that all HCV proteins accumulate on the membranous web, we propose that the membranous web forms the viral replication complex in HCV-infected cells...
  12. pmc Activation of cytomegalovirus in pig-to-primate organ xenotransplantation
    Nicolas J Mueller
    Infectious Diseases Division, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Virol 76:4734-40. 2002
    ..The observation of graft injury by PCMV demonstrates that CMV will be an important pathogen in immunosuppressed xenograft recipients. Strategies must be developed to exclude CMV from porcine organ donors...
  13. ncbi Caveolin-1 is incorporated into mature respiratory syncytial virus particles during virus assembly on the surface of virus-infected cells
    Gaie Brown
    MRC Virology Unit and Division of Virology, University of Glasgow, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 83:611-21. 2002
    ..Collectively, these findings show that cav-1 is incorporated into the envelope of mature RSV particles during egress...
  14. ncbi A guide to viral inclusions, membrane rearrangements, factories, and viroplasm produced during virus replication
    Christopher Netherton
    Vaccinology Group, Pirbright Laboratories, Institute for Animal Health, Surrey, United Kingdom
    Adv Virus Res 70:101-82. 2007
    ....
  15. ncbi Prevention of inclusion body hepatitis/hydropericardium syndrome in progeny chickens by vaccination of breeders with fowl adenovirus and chicken anemia virus
    H Toro
    Faculty of Veterinary Sciences, University Chile, Santiago
    Avian Dis 46:547-54. 2002
    ..FAV vaccination alone produced 24% HIB, similar to challenge strategy 2, demonstrating a lower protective effect...
  16. ncbi Intracytoplasmic inclusions in circulating leukocytes from an eastern box turtle (Terrapene carolina carolina) with iridoviral infection
    Matthew C Allender
    University of Illinois, College of Veterinary Medicine, 2001 South Lincoln Ave, Urbana, Illinois 61802, USA
    J Wildl Dis 42:677-84. 2006
    ....
  17. ncbi Cytomegalovirus co-infection in AIDS-associated oral Kaposi's sarcoma
    S Meer
    Division of Oral Pathology, School of Oral Health Sciences, Private Bag 3, University of the Witwatersrand, Wits, 2050, Johannesburg, South Africa
    Adv Dent Res 19:96-8. 2006
    ..Nonetheless, it is vital that physicians be alerted to active CMV infection, so that timely intervention and careful observation can be instituted, ensuring early diagnosis and treatment...
  18. pmc Ultrastructural characterization of SARS coronavirus
    Cynthia S Goldsmith
    Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 10:320-6. 2004
    ..Electron microscopic studies were critical in identifying the etiologic agent of the SARS outbreak and in guiding subsequent laboratory and epidemiologic investigations...
  19. pmc Reovirus nonstructural protein mu NS recruits viral core surface proteins and entering core particles to factory-like inclusions
    Teresa J Broering
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 78:1882-92. 2004
    ..These findings expand a model for how viral and cellular components are recruited to the viral factories in infected cells and provide further evidence for the central but distinct roles of viral proteins mu NS and mu 2 in this process...
  20. ncbi Assembly of fluorescent chimeric virus-like particles of canine parvovirus in insect cells
    L Gilbert
    Department of Biological and Environmental Science, University of Jyvaskyla, P O Box 35, Jyvaskyla FIN 40014, Finland
    Biochem Biophys Res Commun 313:878-87. 2004
    ..In summary, we have developed fluorescent virus-like nanoparticles carrying a heterologous entity that can be utilized as a visualization tool to elucidate events related to a canine parvovirus infection...
  21. ncbi Highly efficient and economical baculovirus expression system for preparing human papillomavirus type16 virus-like particle
    Jin Zheng
    The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Cancer Research, School of Life Science and Technology, Xi an Jiaotong University, Xi an 710061, China
    Acta Biochim Biophys Sin (Shanghai) 36:548-52. 2004
    ..Hopefully, the present expression and purification system is promising to be convenient, timesaving and economical for preparation of HPV16 VLP vaccine...
  22. ncbi Rice stripe virus 23.9 K protein aggregates and forms inclusion bodies in cultured insect cells and virus-infected plant cells
    M Takahashi
    National Institute for Agro Environmental Sciences, Tsukuba, Ibaraki, Japan
    Arch Virol 148:2167-79. 2003
    ..9 K protein antiserum were observed in virus-infected wheat tissue by electron microscopy. This paper thus demonstrates that RSV 23.9 K protein can aggregate in vivo and form inclusion bodies in infected plant tissue...
  23. ncbi Diagnostic and molecular evaluation of three iridovirus-associated salamander mortality events
    Douglas E Docherty
    USGS, National Wildlife Health Center, 6006 Schroeder Road, Madison, Wisconsin 53711, USA
    J Wildl Dis 39:556-66. 2003
    ..Challenge assays are required to determine the fish and amphibian host range of these isolates and to assess the susceptibility of tiger and spotted salamanders to heterologous virus isolates...
  24. ncbi Productive infection of cerebellar granule cell neurons by JC virus in an HIV+ individual
    R A Du Pasquier
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neurology 61:775-82. 2003
    ..Sequence analysis of the JCV regulatory region from cerebellar virions showed a tandem repeat pattern also found in PML lesions of the frontal lobe WM...
  25. ncbi Ranavirus-associated morbidity and mortality in a group of captive eastern box turtles (Terrapene carolina carolina)
    Ryan De Voe
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Zoo Wildl Med 35:534-43. 2004
    ..The virus was characterized by electron microscopy, polymerase chain reaction, and sequence analysis of a portion of the major capsid protein as a member of the genus Ranavirus...
  26. ncbi Complex intracellular inclusions in the brain of a child with a stealth virus encephalopathy
    W John Martin
    Center for Complex Infectious Diseases, Rosemead, CA 91770, USA
    Exp Mol Pathol 74:197-209. 2003
    ..Many of the intracellular inclusions show highly ordered structuring, while others have a more amorphous appearance. These structures may provide a target for energy-based therapeutic intervention in stealth-virus-infected patients...
  27. ncbi Infection competition against grouper nervous necrosis virus by virus-like particles produced in Escherichia coli
    Ming Wei Lu
    Institute of Marine Resources 804, National Sun Yat Sen University, Kaohsiung, Taiwan
    J Gen Virol 84:1577-82. 2003
    ..The recombinant VLPs block attachment of native virus to the surface of cultured fish nerve cells, blocking infection by the native virus...
  28. ncbi Cytomegalovirus-associated pulmonary septal capillary injury sine inclusion body change: a distinctive cause of occult or macroscopic pulmonary hemorrhage in the immunocompetent host
    Cynthia Magro
    Department of Pathology, Ohio State University, Columbus, Ohio 43210, USA
    Appl Immunohistochem Mol Morphol 13:268-72. 2005
    ....
  29. pmc Spread of hepatitis B viruses in vitro requires extracellular progeny and may be codetermined by polarized egress
    A Funk
    Department of General Virology, Heinrich Pette Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, 20251 Hamburg, Germany
    J Virol 78:3977-83. 2004
    ....
  30. ncbi Brome mosaic virus replicase proteins localize with the movement protein at infection-specific cytoplasmic inclusions in infected barley leaf cells
    K Dohi
    Laboratory of Plant Pathology, Graduate School of Agriculture, Kyoto University, Japan
    Arch Virol 146:1607-15. 2001
    ..The inclusions were oval or amorphous, and contained electron-lucent regions. Electron microscopic autoradiography showed that the inclusions were sites of [3H]uridine incorporation, suggesting that they are sites of viral RNA synthesis...
  31. ncbi Viral behavior of paracrystalline inclusions in osteoclasts of Paget's disease of bone
    S Abe
    Department of Orthopedic Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Ultrastruct Pathol 19:455-61. 1995
    ..These findings suggested that the inclusions showed viral behavior in pagetic osteoclasts, and that the nuclear modifications were caused by virus infection...
  32. pmc Reovirus sigma NS and mu NS proteins form cytoplasmic inclusion structures in the absence of viral infection
    Michelle M Becker
    Department of Microbiology and Immunology and Elizabeth B Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Virol 77:5948-63. 2003
    ..These data suggest that sigma NS and mu NS are the minimal viral components required to form inclusions, which then recruit other reovirus proteins and RNA to initiate viral genome replication...
  33. ncbi Iridovirus disease in two ornamental tropical freshwater fishes: African lampeye and dwarf gourami
    Chaiwud Sudthongkong
    Faculty of Bioresources, Mie University, Tsu, Japan
    Dis Aquat Organ 48:163-73. 2002
    ..The nucleotide sequence of PCR products derived from ALIV (696 base pairs) and DGIV (701 base pairs) had 95.3% identity. These results indicate that ALIV and DGIV have a single origin...
  34. ncbi The hydropericardium syndrome in poultry--a current scenario
    V Balamurugan
    Division of Avian Diseases, Indian Veterinary Research Institute, Izatnagar, Bareilly, UP 243 122, India
    Vet Res Commun 28:127-48. 2004
    ..The vaccines are effective in the face of natural outbreaks or experimental challenge and significantly reduce the mortality...
  35. ncbi Inclusion body hepatitis as a primary disease in broilers in Saskatchewan, Canada
    Susantha Gomis
    Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5B4
    Avian Dis 50:550-5. 2006
    ....
  36. ncbi Vertical induction of the inclusion body hepatitis/hydropericardium syndrome with fowl adenovirus and chicken anemia virus
    H Toro
    Faculty of Veterinary Sciences, University of Chile, Santiago
    Avian Dis 45:215-22. 2001
    ....
  37. ncbi Hydropericardium syndrome in Japanese quail (Coturnix coturnix japonica)
    P Roy
    Central University Laboratory, Madras Veterinary College, Tamilnadu Veterinary and Animal Sciences University, Madhavaram Milk Colony, Chennai 600 051, India
    Vet Rec 155:273-4. 2004
  38. ncbi Genetic characterization, pathogenicity, and protection studies with an avian adenovirus isolate associated with inclusion body hepatitis
    I R Alvarado
    Department of Population Health, University of Georgia, Athens, GA 30602, USA
    Avian Dis 51:27-32. 2007
    ..We conclude that broiler-breeder progenies from 30- to 50-wk-old grandparents vaccinated with the AAV 8/11 vaccine were adequately protected against challenge with the AAV 8 and 11 serotypes and the Stanford strain...
  39. ncbi Genotyping of Canadian isolates of fowl adenoviruses
    Davor Ojkic
    Animal Health Laboratory, University of Guelph, Guelph, Ontario, Canada
    Avian Pathol 37:95-100. 2008
    ..Co-infection rates in non-IBH submissions were 50.00% for infectious bursal disease virus, 40.70% for infectious bronchitis virus, 27.91% for reoviruses and 1.16% for Newcastle disease virus...
  40. ncbi Barley stripe mosaic virus-encoded proteins triple-gene block 2 and gammab localize to chloroplasts in virus-infected monocot and dicot plants, revealing hitherto-unknown roles in virus replication
    L Torrance
    Plant Pathology Programme, Scottish Crop Research Institute SCRI, Invergowrie, Dundee DD2 5DA, UK
    J Gen Virol 87:2403-11. 2006
    ..The results indicate that TGB2 and gammab proteins play a previously unknown functional role at the site of virus replication...
  41. pmc Increased ubiquitination and other covariant phenotypes attributed to a strain- and temperature-dependent defect of reovirus core protein mu2
    Cathy L Miller
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA
    J Virol 78:10291-302. 2004
    ..Because so few of the viral strains formed factories that were regularly associated with ubiquitinated proteins, we conclude that reovirus factories are generally distinct from cellular aggresomes...
  42. ncbi The spread of tobacco mosaic virus infection: insights into the cellular mechanism of RNA transport
    M Heinlein
    Friedrich Miescher Institute, Basel, Switzerland
    Cell Mol Life Sci 59:58-82. 2002
    ..This review summarizes current knowledge of Tobacco mosaic virus infection with emphasis on the mechanism by which this virus targets its RNA genome from sites of replication to plasmodesmata to achieve intercellular spread...
  43. ncbi Purification and properties of the vaccinia virus mRNA processing factor
    Susan M D'Costa
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida 32610 0266, USA
    J Biol Chem 283:5267-75. 2008
    ..In addition, we show that dephosphorylation of a cleavage competent extract with a nonspecific phosphatase abolishes cleavage activity implying a role for phosphorylation in cleavage activity...
  44. ncbi The uninvited guest: JC virus infection of neurons in PML
    Kenneth L Tyler
    Neurology 61:734-5. 2003
  45. ncbi Complete unilateral ophthalmoplegia in herpes zoster ophthalmicus
    Srinivasan Sanjay
    Department of Ophthalmology and Visual Sciences, Alexandra Hospital, Singapore
    J Neuroophthalmol 29:325-37. 2009
    ..cerebral circulation, as well as periaxial infarction in the optic nerve, pons, and medulla but without viral inclusion bodies or antigen...
  46. ncbi Usefulness of dead shrimp specimens in studying the epidemiology of white spot syndrome virus (WSSV) and chronic bacterial infection
    C V Mohan
    Department of Aquaculture, College of Fisheries, University of Agricultural Sciences, Mangalore, India
    Dis Aquat Organ 50:1-8. 2002
    ..Intranuclear viral inclusion bodies diagnostic of WSSV infection were detected in dead samples from 32 ponds (64 %)...
  47. pmc Respiratory syncytial virus induces host RNA stress granules to facilitate viral replication
    Michael E Lindquist
    Departments of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2905, USA
    J Virol 84:12274-84. 2010
    ..We also showed that stress granules are distinct from cytoplasmic viral inclusion bodies and that the RNA binding protein HuR, normally found in stress granules, also localized to viral inclusion ..
  48. ncbi Host factor Ebp1 inhibits rinderpest virus transcription in vivo
    M Gopinath
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India
    Arch Virol 155:455-62. 2010
    ..Ebp1 protein has been shown to co-localize with viral inclusion bodies in infected cells, and it is packaged into virions, presumably through its interaction with the N protein ..
  49. ncbi [Ultrastructural observation of rat thymus tissue with coronavirus infection]
    Ying jie Piao
    Department of Histology and Embryology, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 23:414-5, 420. 2003
    ..To investigate the ultrastructure of rat thymus tissues with rat coronavirus (RCV) infection for clarifying the mechanism responsible for the morphological changes of the cells infected by RCV...
  50. ncbi Nucleocapsid formation and/or subsequent conformational change of rabies virus nucleoprotein (N) is a prerequisite step for acquiring the phosphatase-sensitive epitope of monoclonal antibody 5-2-26
    A Kawai
    Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Sakyo ku, 606 8501, Japan
    Virology 263:395-407. 1999
    ..mutant N proteins were shown to be similarly accumulated as the wild-type N proteins into the viral inclusion bodies, defined as the virus-specific structures composed of viral nucleocapsids, that are produced in the ..
  51. ncbi Polyomavirus nephropathy in native kidneys and renal allografts: an update on an escalating threat
    Volker Nickeleit
    Nephropathology Laboratory, Department of Pathology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    Transpl Int 19:960-73. 2006
    ..BKN is morphologically defined by the presence of intranuclear viral inclusion bodies in epithelial cells and tubular injury, which is the morphological correlate for renal dysfunction...
  52. ncbi YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter
    Per S Holm
    Institut für Experimentelle Onkologie und Therapieforschung, Technische Universitat Munchen, Klinikum rechts der Isar, Munchen 81675, Germany
    J Biol Chem 277:10427-34. 2002
    ..transcription factor YB-1 to the nuclei of adenovirus type 5-infected cells where it is associated with viral inclusion bodies believed to be sites of viral transcription and replication...
  53. ncbi Clinical, histologic, and immunohistochemical characterization of wart-like lesions on the paw pads of dogs: 24 cases (2000-2007)
    Jason M Balara
    Department of Veterinary Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA
    J Am Vet Med Assoc 234:1555-8. 2009
    ..biopsy specimens (n = 11) were submitted for immunohistochemical staining and a PCR assay to identify viral inclusion bodies. RESULTS- In Greyhounds, most lesions involved the pads of the third and fourth digits, had a consistent ..
  54. ncbi Parvovirus B19: a pathogen responsible for more than hematologic disorders
    Burkhard D Bültmann
    Institute of Pathology, University of Tubingen, Liebermeisterstrasse 8, D 72076 Tubingen, Germany
    Virchows Arch 442:8-17. 2003
    ..lytic infections occurring in transient aplastic anemia or nonimmune hydrops fetalis by the detection of viral inclusion bodies in erythroid precursor cells...
  55. ncbi Mortality due to polyomavirus infection in two nightjars (Caprimulgus europaeus)
    Ana Sofia Arroube
    Veterinary Faculty, Evora University, Portugal
    J Avian Med Surg 23:136-40. 2009
    ..On histologic examination, intranuclear viral inclusion bodies consistent with avian polyomavirus were observed in the liver, spleen, and kidneys...
  56. ncbi Interferon-induced inhibition of parainfluenza virus type 5; the roles of MxA, PKR and oligo A synthetase/RNase L
    T S Carlos
    School of Biology, University of St Andrews, Fife KY16 9ST, Scotland, UK
    Virology 363:166-73. 2007
    ..treatment also caused a rapid redistribution of virus proteins and enhanced the formation of cytoplasmic viral inclusion bodies. The most studied IFN-induced genes with known anti-viral activity are MxA, PKR and the Oligo A synthetase/..
  57. ncbi Presence of occult cytomegalovirus infection in the brain after orthotopic liver transplantation. An autopsy study of 83 cases
    Teresa Ribalta
    Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona Medical School, Spain
    Virchows Arch 440:166-71. 2002
    ..6%), and in 5 controls (13.8%) (P=0.00017). Viral inclusion bodies, inflammatory infiltrates, or necrotizing changes were not identified in any case...
  58. ncbi Fatal disseminated adenoviral infection associated with thrombotic thrombocytopenic purpura after allogeneic bone marrow transplantation
    A B Fassas
    Department of Medicine, Greenebaum Cancer Center, University of Maryland, Baltimore, USA
    Leuk Lymphoma 42:801-4. 2001
    ..Liver biopsy showed parenchymal necrosis with intranuclear viral inclusion bodies. Immunohistochemistry was positive for adenovirus...
  59. ncbi Expression of the rice hoja blanca virus (RHBV) non-structural protein 3 (NS3) in Escherichia coli and its in situ localization in RHBV-infected rice tissues
    Miguel Munoz
    Centro de Investigacion en Biologia Celular y Molecular, Universidad de Costa Rica
    Rev Biol Trop 52:765-75. 2004
    ..viral nucleocapsid protein revealed in situ accumulation of NS3 protein in the cytoplasm but not in the viral inclusion bodies, vacuoles or chloroplasts of RHBV-infected plants, following the same pattern of distribution as the RHBV ..
  60. ncbi The molecular organization of cypovirus polyhedra
    Fasseli Coulibaly
    School of Biological Sciences, University of Auckland, 1010, New Zealand
    Nature 446:97-101. 2007
    ..The structure suggests that polyhedra can serve as the basis for the development of robust and versatile nanoparticles for biotechnological applications such as microarrays and biopesticides...
  61. ncbi Viruses as agents of disease. 1948
    Thomas Francis
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:S17-21. 2005
  62. ncbi Cytomegalovirus infection of the upper gastrointestinal tract: a clinical and pathological study of 30 cases
    Luca Reggiani Bonetti
    Section of Pathologic Anatomy, Azienda Ospedaliera Universitaria, Policlinico, Modena, Italy
    Scand J Gastroenterol 46:1228-35. 2011
    ..The study reviews the endoscopic and histological features of human cytomegalovirus (HCMV) infections of the upper gastrointestinal (UGI) tract...
  63. ncbi Detection of infectious myonecrosis virus in penaeid shrimps using immunoassays: usefulness of monoclonal antibodies directed to the viral major capsid protein
    Mariana Borsa
    Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina, UFSC, Florianopolis, Brazil
    Arch Virol 156:9-16. 2011
    ..a ~100-kDa protein, which corresponds to the predicted mass of the IMNV major capsid protein, as well as viral inclusion bodies in muscle fibroses by western blot and immunohistochemistry...
  64. ncbi Columbid herpesvirus-1 in two Cooper's hawks (Accipiter cooperii) with fatal inclusion body disease
    Marie E Pinkerton
    Veterinary Diagnostic Laboratory and Department of Pathobiology, College of Veterinary Medicine, University of Illinois, 2001 South Lincoln Avenue, Urbana, IL 61802, USA
    J Wildl Dis 44:622-8. 2008
    ..PCR results provide evidence that this disease is transmitted to raptors via Rock Pigeons, most likely through ingestion of Rock Pigeons as prey...
  65. ncbi Congenital cytomegalovirus infection: a cause of renal dysplasia?
    Maren Chan
    Department of Pathology at Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Pediatr Dev Pathol 10:300-4. 2007
    ..Herein, we describe a case of unilateral renal dysplasia in a 19-week fetus with concurrent CMV infection. We believe the present case to be the first description of a virus apparently inducing renal multicystic dysplasia...
  66. ncbi Avian polyomavirus infection of a fledgling budgerigar (Melopsittacus undulatus) and differential diagnoses of viral inclusions in psittacine birds--case report and mini-review
    Vanessa Herder
    Department of Pathology, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany
    Berl Munch Tierarztl Wochenschr 124:209-16. 2011
    ..on fresh skin samples was negative whereas on formalin-fixed kidney samples with a high amount of viral inclusion bodies yielded a positive result...
  67. ncbi [Clinical features of severe intestinal graft-versus-host disease in 34 cases following allogeneic hematopoietic stem cell transplantation]
    Rong Mu Luo
    Department of Hematopoietic Stem Cell Transplantation, Beijing Dao pei Hospital, Beijing, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 19:1501-4. 2011
    ..The deep ulcers could be found under colonoscope. Histopathologic examination revealed the viral inclusion bodies or positive viral antigen...
  68. ncbi Non-permissive C6/36 cell culture for the Australian isolate of Macrobrachium rosenbergii nodavirus
    O Hayakijkosol
    School of Veterinary and Biomedical Sciences, James Cook University, QLD, Australia
    J Fish Dis 36:401-9. 2013
    ..Typical cytopathic effects such as vacuolation and viral inclusion bodies were observed in infected C6/36 cells with H&E and Giemsa staining...
  69. ncbi Novel polyomaviral infection in the placenta of a northern fur seal (Callorhinus ursinus) on the Pribilof Islands, Alaska, USA
    Colleen Duncan
    Colorado State University Veterinary Diagnostic Laboratory, 300 West Drake Ave, Fort Collins, Colorado 80523, USA
    J Wildl Dis 49:163-7. 2013
    ..In 2010, intranuclear viral inclusion bodies were identified in trophoblasts of a single northern fur seal (NFS; Callorhinus ursinus) placenta from a ..
  70. pmc Direct evidence for a chronic CD8+-T-cell-mediated immune reaction to tax within the muscle of a human T-cell leukemia/lymphoma virus type 1-infected patient with sporadic inclusion body myositis
    Simona Ozden
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Paris, France
    J Virol 78:10320-7. 2004
    ....
  71. ncbi Autographa californica multiple nucleopolyhedrovirus ac66 is required for the efficient egress of nucleocapsids from the nucleus, general synthesis of preoccluded virions and occlusion body formation
    Jianhao Ke
    State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen University, 510275 Guangzhou, China
    Virology 374:421-31. 2008
    ..These results suggested that ac66 plays an important role for the efficient exit of nucleocapsids from the nucleus to the cytoplasm for BV synthesis as well as for preoccluded virion and occlusion synthesis...
  72. pmc The respiratory syncytial virus fusion protein targets to the perimeter of inclusion bodies and facilitates filament formation by a cytoplasmic tail-dependent mechanism
    Pradyumna S Baviskar
    Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma, USA
    J Virol 87:10730-41. 2013
    ..in CT-R2 but not CT-R1 led to accumulation of M and F proteins within and at the perimeter of viral inclusion bodies (IBs), respectively...
  73. pmc Nuclear import of CaMV P6 is required for infection and suppression of the RNA silencing factor DRB4
    Gabrielle Haas
    Institut de Biologie Moleculaire des Plantes, CNRS UPR2353, Universite Louis Pasteur, Strasbourg, France
    EMBO J 27:2102-12. 2008
    ..This study identifies both genetic and physical interactions between a VSR to a host RNA silencing component, and highlights the importance of subcellular compartmentalization in VSR function...
  74. ncbi High and compact formation of baculoviral polyhedrin-induced inclusion body by co-expression of baculoviral FP25 in Escherichia coli
    Lin Li
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790 784, Korea
    Biotechnol Bioeng 96:1183-90. 2007
    ..Therefore, co-expression of baculoviral FP25 can be promisingly used to increase the levels of baculoviral Polh-fused foreign proteins, especially harmful proteins, expressed as inclusion bodies in an E. coli expression system...
  75. pmc Characterization of fowl adenoviruses isolated in Ontario and Quebec, Canada
    Davor Ojkic
    Animal Health Laboratory, Laboratory Services Division, University of Guelph, Guelph, Ontario NIG 2W1
    Can J Vet Res 72:236-41. 2008
    ..The number of serotype 8 virus isolations has increased over the years, and by 2001 serotype 8 had become the dominant serotype in Ontario, and continues to be so. Moreover, this virus (FAdV-8) has shown a strong association with IBH...
  76. ncbi Clinicopathological and ultrastructural study of multiple lobular capillary hemangioma after scalding
    Wen Jun Liao
    Center of Dermatology of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi an, China
    Dermatology 213:34-6. 2006
    ..Ultrastructural examination revealed features typical of a lobular capillary hemangioma and viral inclusion bodies in the epidermis of case 1. Multiple lobular capillary hemangiomas after scalding are rarely reported...
  77. ncbi Bombyx mori nucleopolyhedrovirus SNF2 global transactivator homologue (Bm33) enhances viral pathogenicity in B. mori larvae
    Susumu Katsuma
    Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    J Gen Virol 89:3039-46. 2008
    ..mori larvae when tested by either BV injection or OB ingestion. These results suggest that Bm33 is not essential for virus growth in vitro or in vivo, but that it accelerates the time of death of B. mori larvae...
  78. pmc Refolding, crystallization and preliminary X-ray structural studies of the West Nile virus envelope (E) protein domain III
    Fang Yuan
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford University, Oxford OX3 9DU, England
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:421-3. 2005
    ..The crystals belong to space group P222(1), with unit-cell parameters a = 52.6, b = 59.7, c = 95.0 A. A complete data set was collected to 2.8 A at 100 K with Cu Kalpha X-rays from a rotating-anode generator...
  79. ncbi Detection and localization of Rice stripe virus gene products in vivo
    Delin Liang
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, HMR 400, 2011 Zonal Ave, Los Angeles, CA 90033, USA
    Virus Genes 31:211-21. 2005
    ..Our results confirm the in vivo ambisense coding strategy of Tenuivirus RNA 2 and provide further evidence that RSV does not produce enveloped virions in infected rice plants...
  80. pmc Combined distemper-adenoviral pneumonia in a dog
    Luis E Rodriguez-Tovar
    Departamento de Patologia, Facultad de Medicina Veterinaria y Zootecnia, UANL, Avenida Lázaro Cárdenas 4600 pte, Unidad Universitaria Mederos, Monterrey, N L CP 64930, Mexico
    Can Vet J 48:632-4. 2007
    ..Presence of both viruses was confirmed via immunohistochemical staining...
  81. ncbi Recurrent cytomegalovirus colitis with megacolon in an immunocompetent elderly man
    Yi Hsuan Lin
    Division of Digestive Therapeutic Endoscopy, Department of Gastroenterology, Chang Gung Memorial Hospital, Linkou Medical Center, Tao Yuan, Taiwan
    J Med Virol 82:638-41. 2010
    ..Colitis caused by CMV colitis should be considered in elderly people with diarrhea...
  82. ncbi Insecticidal properties and microbial contaminants in a Spodoptera exigua multiple nucleopolyhedrovirus (Baculoviridae) formulation stored at different temperatures
    Rodrigo Lasa
    Departamento de Producción Agraria, Universidad Publica de Navarra, Pamplona 31006, Spain
    J Econ Entomol 101:42-9. 2008
    ..We conclude that OB formulation with bacteriostatic or antioxidant additives, together with storage and distribution in refrigerated conditions, will likely result in an SeMNPV biopesticide shelf life that exceeds 18 mo...
  83. ncbi Isolation of etiological agent of hydropericardium syndrome in chicken embryo liver cell culture and its serological characterization
    Rajesh Kumar
    Department of Veterinary Microbiology, College of Veterinary Sciences, G B Pant University of Agriculture and Technology, Pantnagar 263 145
    Indian J Exp Biol 41:821-6. 2003
    ....
  84. ncbi Partial characterization of retroviruses from boid snakes with inclusion body disease
    E R Jacobson
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA
    Am J Vet Res 62:217-24. 2001
    ..Whether this virus represents the causative agent of IBD is yet to be determined. The isolation of retroviruses from boid snakes with IBD is an important step n the process of identifying the causative agent of this disease...
  85. ncbi Detection of porcine circovirus 2 (PCV-2) DNA by nested PCR from formalin-fixed tissues of post-weaning multisystemic wasting syndrome (PMWS) pigs in Thailand
    Wijit Kiatipattanasakul-Banlunara
    Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand
    J Vet Med Sci 64:449-52. 2002
    ..Histopathology showed characteristic lesions of PMWS and intracytoplasmic viral inclusion bodies in macrophages infiltrating in lymphoid tissues...
  86. ncbi Gastrointestinal pathogenicity of adenoviruses and reoviruses isolated from broiler chickens in Alabama
    S D Lenz
    Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849 5519, USA
    J Vet Diagn Invest 10:145-51. 1998
    ..Intranuclear viral inclusion bodies occurred in gizzard epithelium and pancreatic acinar cells at the sites of lesions...
  87. ncbi Nucleic acid-binding properties and subcellular localization of the 3a protein of brome mosaic bromovirus
    M Fujita
    Laboratory of Plant Pathology, Graduate School of Agriculture, Kyoto University, Japan
    J Gen Virol 79:1273-80. 1998
    ..Immunogold labelling of thin sections of infected barley tissues revealed that B3a was associated with plasmodesmata and cytoplasmic inclusions...
  88. ncbi Serological association between spirorchidiasis, herpesvirus infection, and fibropapillomatosis in green turtles from Florida
    L H Herbst
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA
    J Wildl Dis 34:496-507. 1998
    ..The strong association between antibody reactivity to herpesvirus antigens and GTFP status in both captive-reared and free-ranging turtles is consistent with the hypothesis that the transmissible agent that causes GTFP is a herpesvirus...
  89. ncbi A novel immunohistochemical assay for the detection of Ebola virus in skin: implications for diagnosis, spread, and surveillance of Ebola hemorrhagic fever. Commission de Lutte contre les Epidémies à Kikwit
    S R Zaki
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 179:S36-47. 1999
    ..IHC testing of formalin-fixed skin specimens is a safe, sensitive, and specific method for laboratory diagnosis of EHF and should be useful for EHF surveillance and prevention...
  90. ncbi Cytomegalovirus-induced necrotizing and crescentic glomerulonephritis in a renal transplant patient
    R K Detwiler
    Department of Pathology, East Carolina University School of Medicine, Greenville, NC 27858, USA
    Am J Kidney Dis 32:820-4. 1998
    ..This case represents the first report of CMV-associated NCGN in a renal transplant patient...
  91. pmc Relapsing herpes simplex encephalitis: pathological confirmation of viral reactivation
    S Yamada
    Department of Neurology, Gifu Prefectural Tajimi Hospital, Gifu, Japan
    J Neurol Neurosurg Psychiatry 74:262-4. 2003
    ..This is the first case report demonstrating HSV-1 antigen, HSV-1 DNA, and herpes simplex virus nucleocapsids in a case of relapsing herpes simplex encephalitis...
  92. ncbi Renal allograft dysfunction associated with cytomegalovirus infection
    M J Shaver
    Division of Nephrology and Department of Pathology at the University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
    Am J Kidney Dis 34:942-6. 1999
    ..Further studies are needed to establish the mechanism of allograft dysfunction in the absence of inflammatory changes...
  93. ncbi Experimental infection of lacertids with lizard erythrocytic viruses
    António Pedro Alves de Matos
    Anatomic Pathology Department, Electron Microscopy Unit, Curry Cabral Hospital, Lisbon, Portugal
    Intervirology 45:150-9. 2002
    ..This work reports on an experimental study of the infection process in Lacerta monticola and Lacerta schreiberi from Serra da Estrela Mountain, Portugal...
  94. ncbi Pathogenesis of experimental Ebola Zaire virus infection in BALB/c mice
    T R Gibb
    Diagnostic Systems, United States Army Medical Research Institute of Infectious Diseases (USAMRIID, Fort Detrick, Frederick, Maryland 21702-5011, USA
    J Comp Pathol 125:233-42. 2001
    ..The availability of immunodeficient, "gene-knockout" and transgenic mice will make the mouse model particularly useful for studying the early steps of Ebola pathogenesis...
  95. pmc Reovirus sigma NS protein localizes to inclusions through an association requiring the mu NS amino terminus
    Cathy L Miller
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 77:4566-76. 2003
    ..The results of this study provide further evidence that mu NS plays a key role in forming the reovirus factories and recruiting other components to them...
  96. ncbi Overcoming inclusion body formation in a high-level expression system
    J T Moore
    Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany
    Protein Expr Purif 4:160-3. 1993
    ..The use of a rich growth medium during the course of protein induction may be a valuable adjunct to limiting inclusion body formation with this as well as other expression systems...
  97. ncbi The clinical pathology of severe acute respiratory syndrome (SARS): a report from China
    Yanqing Ding
    Department of Pathology, Nan Fang Hospital, First Military Medical University, Guangzhou, Guangdong Province 510515, PR China
    J Pathol 200:282-9. 2003
    ..of protein and monocytes, lymphocytes and plasma cells in alveoli, hyaline membrane formation, and viral inclusion bodies in alveolar epithelial cells...
  98. pmc Molluscum contagiosum in an immune reconstituted AIDS patient
    T Albini
    Br J Ophthalmol 87:1427-8. 2003
  99. ncbi [Changes in ultrastructure and protein metabolism of tobacco plants infected by tomato spotted wilt virus]
    O H Kovalenko
    Tsitol Genet 37:24-9. 2003
    ..At the same time it induces formation of at least three pathogenesis-associated proteins (PR-proteins) and two antiviral factors of the types AVF (6) and IVR (7) active towards tobacco mosaic virus...
  100. ncbi Identification of cytomegalovirus in a liquid-based gynecologic sample using morphology, immunohistochemistry, and DNA real-time PCR detection
    Harmanjatinder S Sekhon
    Division of Cytopathology and Division of Molecular Diagnostics, Department of Pathology, Oregon Health and Sciences University, Portland, Oregon 97201, USA
    Diagn Cytopathol 30:411-7. 2004
    ..These observations suggest that a liquid-based preparation can be used to assess CMV infection morphologically, immunohistochemically, and by real-time PCR...
  101. ncbi [Study on etiology and pathology of severe acute respiratory syndrome]
    Yan qing Ding
    Department of Pathology, Nanfang Hospital, The First Military Medical University, Guangzhou 510515, China
    Zhonghua Bing Li Xue Za Zhi 32:195-200. 2003
    ..To investigate the clinicopathologic characteristics of severe acute respiratory syndrome (SARS)...

Research Grants8

  1. Viral inclusion bodies and aggresomes: form and function
    John Parker; Fiscal Year: 2004
    ..This research should significantly advance our understanding of how cytopathology and disease are induced during viral and neurodegenerative disease by the formation of intracellular inclusion bodies. ..
  2. MEASLES VACCINES--IMMUNE RESPONSES AND ATYPICAL MEASLES
    Diane Griffin; Fiscal Year: 2001
    ....
  3. Immune Responses During Measles Virus Infection
    Diane Griffin; Fiscal Year: 2007
    ..3. To determine the roles of different CD4 and CD8 T cell populations in production of cytokines at various times during measles and the effect of concurrent HIV infection on these roles. ..
  4. 2007 Viruses & Cells Gordon Conference
    Diane Griffin; Fiscal Year: 2007
    ..abstract_text> ..
  5. Infectious Diseases of the Nervous System: Pathogenesis and Worldwide Impact
    Diane Griffin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. ACUTE ALPHAVIRAL ENCEPHALITIS
    Diane Griffin; Fiscal Year: 2008
    ..abstract_text> ..
  7. Experimental Creutzfeldt Jacob Disease
    Laura Manuelidis; Fiscal Year: 2007
    ..Rapid infectivity assays in vitro can open the study of TSEs by providing a way to test any pure molecule or structure for its intrinsic infectivity by Koch's established postulates for infectious pathogens. ..
  8. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    ..Our research will be useful in the development of novel treatments for the most aggressive forms of the childhood cancer neuroblastoma. ..