desmosomes

Summary

Summary: A type of junction that attaches one cell to its neighbor. One of a number of differentiated regions which occur, for example, where the cytoplasmic membranes of adjacent epithelial cells are closely apposed. It consists of a circular region of each membrane together with associated intracellular microfilaments and an intercellular material which may include, for example, mucopolysaccharides. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990; Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

Top Publications

  1. pmc The desmosome
    Emmanuella Delva
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cold Spring Harb Perspect Biol 1:a002543. 2009
  2. pmc p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome
    Giustina Ferone
    Fondazione IRCCS SDN, Napoli, Italy
    Hum Mol Genet 22:531-43. 2013
  3. pmc Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates
    T M Magin
    Institut fuer Genetik, Abteilung Molekulargenetik, Universitat Bonn, Bonn, Germany
    J Cell Biol 140:1441-51. 1998
  4. pmc Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis
    VERONICA G BEAUDRY
    Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Genet 6:e1001168. 2010
  5. ncbi Desmosomal gene analysis in arrhythmogenic right ventricular dysplasia/cardiomyopathy: spectrum of mutations and clinical impact in practice
    Veronique Fressart
    AP HP, Hopital Pitie Salpetriere, Service de Biochimie, Unité de Cardiogénétique et Myogénétique, Paris, France
    Europace 12:861-8. 2010
  6. pmc Desmoplakin: an unexpected regulator of microtubule organization in the epidermis
    Terry Lechler
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
    J Cell Biol 176:147-54. 2007
  7. ncbi Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice
    E Georges-Labouesse
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, C U de Strasbourg, France
    Nat Genet 13:370-3. 1996
  8. ncbi Desmosomes: adhesive strength and signalling in health and disease
    Helen A Thomason
    University of Manchester, UK
    Biochem J 429:419-33. 2010
  9. ncbi Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy
    Brenda Gerull
    Max Delbrueck Center for Molecular Medicine, D 13092 Berlin Buch, Germany
    Nat Genet 36:1162-4. 2004
  10. ncbi Cell-cell connectivity: desmosomes and disease
    Matthew A Brooke
    Centre for Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, UK
    J Pathol 226:158-71. 2012

Detail Information

Publications336 found, 100 shown here

  1. pmc The desmosome
    Emmanuella Delva
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cold Spring Harb Perspect Biol 1:a002543. 2009
    b>Desmosomes are intercellular junctions that tether intermediate filaments to the plasma membrane. Desmogleins and desmocollins, members of the cadherin superfamily, mediate adhesion at desmosomes...
  2. pmc p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome
    Giustina Ferone
    Fondazione IRCCS SDN, Napoli, Italy
    Hum Mol Genet 22:531-43. 2013
    ..mechanical stress, which was alleviated by epidermal growth factor receptor inhibitors known to stabilize desmosomes. Our study reveals that p63 is a crucial regulator of a subset of desmosomal genes and that this function is ..
  3. pmc Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates
    T M Magin
    Institut fuer Genetik, Abteilung Molekulargenetik, Universitat Bonn, Bonn, Germany
    J Cell Biol 140:1441-51. 1998
    ..In young K18 null mice, hepatocytes were completely devoid of keratin filaments. Nevertheless, typical desmosomes were formed and maintained...
  4. pmc Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis
    VERONICA G BEAUDRY
    Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Genet 6:e1001168. 2010
    ..the functional consequence of desmosome inactivation for tumorigenesis are essential for elucidating the role of desmosomes in cancer development...
  5. ncbi Desmosomal gene analysis in arrhythmogenic right ventricular dysplasia/cardiomyopathy: spectrum of mutations and clinical impact in practice
    Veronique Fressart
    AP HP, Hopital Pitie Salpetriere, Service de Biochimie, Unité de Cardiogénétique et Myogénétique, Paris, France
    Europace 12:861-8. 2010
    ..We wanted to address the potential impact of genotyping...
  6. pmc Desmoplakin: an unexpected regulator of microtubule organization in the epidermis
    Terry Lechler
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
    J Cell Biol 176:147-54. 2007
    ..Bornens. 2000. J. Cell Sci. 113:3013-3023), is lost from the centrosome and is recruited to desmosomes by desmoplakin (DP). Loss of DP prevents accumulation of cortical microtubules in vivo and in vitro...
  7. ncbi Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice
    E Georges-Labouesse
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, C U de Strasbourg, France
    Nat Genet 13:370-3. 1996
    ..Our study provides evidence that some forms of epidermolysis bullosa may originate from defects of the alpha 6 gene...
  8. ncbi Desmosomes: adhesive strength and signalling in health and disease
    Helen A Thomason
    University of Manchester, UK
    Biochem J 429:419-33. 2010
    b>Desmosomes are intercellular junctions whose primary function is strong intercellular adhesion, known as hyperadhesion...
  9. ncbi Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy
    Brenda Gerull
    Max Delbrueck Center for Molecular Medicine, D 13092 Berlin Buch, Germany
    Nat Genet 36:1162-4. 2004
    ..In two kindreds with ARVC, disease was incompletely penetrant in most carriers of PKP2 mutations...
  10. ncbi Cell-cell connectivity: desmosomes and disease
    Matthew A Brooke
    Centre for Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, UK
    J Pathol 226:158-71. 2012
    ..cell, direct cell-cell adherence and communication is mediated by the intercellular junction complexes: desmosomes, adherens, tight and gap junctions...
  11. ncbi Working out the strength and flexibility of desmosomes
    Spiro Getsios
    Department of Pathology, Robert H Lurie Cancer Center, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Nat Rev Mol Cell Biol 5:271-81. 2004
  12. ncbi Desmosomal genodermatoses
    G Petrof
    St John s Institute of Dermatology, King s College London Guy s Campus, London SE1 9RT, UK
    Br J Dermatol 166:36-45. 2012
    b>Desmosomes are intercellular junctions that contribute to cell-cell adhesion, signalling, development and differentiation in various tissues, including the skin...
  13. pmc Desmosomes: a role in cancer?
    M Chidgey
    Division of Medical Sciences, University of Birmingham, Clinical Research Block, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Br J Cancer 96:1783-7. 2007
    Much evidence now attests to the importance of desmosomes and their constituents in cancer...
  14. ncbi Desmoglein versus non-desmoglein signaling in pemphigus acantholysis: characterization of novel signaling pathways downstream of pemphigus vulgaris antigens
    Alex I Chernyavsky
    Department of Dermatology, University of California, Davis, California 95816, USA
    J Biol Chem 282:13804-12. 2007
    ..activation of p38 MAPK is a late signaling step associated with collapse of the cytoskeleton and disassembly of desmosomes caused by upstream events involving Src and EGFRK...
  15. ncbi Genetic evidence for a novel human desmosomal cadherin, desmoglein 4
    Neil V Whittock
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, United Kingdom
    J Invest Dermatol 120:523-30. 2003
    b>Desmosomes are essential adhesion structures in most epithelia that link the intermediate filament network of one cell to its neighbor, thereby forming a strong bond...
  16. ncbi De novo desmin-mutation N116S is associated with arrhythmogenic right ventricular cardiomyopathy
    Baerbel Klauke
    Herz and Diabeteszentrum NRW, Klinik f Thorax und Kardiovaskularchirurgie, Erich und Hanna Klessmann Institutfür Kardiovaskulaere Forschung und Entwicklung Klinik fuer angeborene Herzfehler, Georgstrasse 11, Bad Oeynhausen, Germany
    Hum Mol Genet 19:4595-607. 2010
    ..Thus, the gene coding for desmin appears to be a novel ARVC gene, which should be included in molecular genetic screening of ARVC patients...
  17. ncbi Desmoplakin is essential in epidermal sheet formation
    V Vasioukhin
    Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637, USA
    Nat Cell Biol 3:1076-85. 2001
    ..The number of epidermal desmosomes in DP-null skin is similar to wild type (WT), but they lack keratin filaments, which compromise their function...
  18. ncbi The cardiac desmosome and arrhythmogenic cardiomyopathies: from gene to disease
    Mario Delmar
    Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor, Mich, USA
    Circ Res 107:700-14. 2010
    ..Mechanical continuity is provided by desmosomes and adherens junctions, while gap junctions provide a pathway for passage of ions and small molecules between ..
  19. ncbi Desmosome structure, composition and function
    David Garrod
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Biochim Biophys Acta 1778:572-87. 2008
    b>Desmosomes are intercellular junctions of epithelia and cardiac muscle...
  20. ncbi Perp is a p63-regulated gene essential for epithelial integrity
    Rebecca A Ihrie
    Division of Radiation and Cancer Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cell 120:843-56. 2005
    ..Perp localizes specifically to desmosomes, adhesion junctions important for tissue integrity, and numerous structural defects in desmosomes are observed ..
  21. ncbi Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy
    Zhao Yang
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Circ Res 99:646-55. 2006
    ..These data suggest DSP expression in cardiomyocytes is crucial for maintaining cardiac tissue integrity, and DSP abnormalities result in ARVD/C by cardiomyocyte death, changes in lipid metabolism, and defects in cardiac development...
  22. pmc Compound and digenic heterozygosity contributes to arrhythmogenic right ventricular cardiomyopathy
    Tianhong Xu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    J Am Coll Cardiol 55:587-97. 2010
    ..The aim of this study was to define the genetic basis of arrhythmogenic right ventricular cardiomyopathy (ARVC)...
  23. ncbi Age- and training-dependent development of arrhythmogenic right ventricular cardiomyopathy in heterozygous plakoglobin-deficient mice
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Muenster, Germany
    Circulation 114:1799-806. 2006
    ..To test the hypothesis that reduced desmosomal protein expression causes ARVC, we studied the cardiac effects of heterozygous plakoglobin deficiency in mice...
  24. ncbi Desmoglein endocytosis and desmosome disassembly are coordinated responses to pemphigus autoantibodies
    Catharine C Calkins
    Departments of Dermatology and Cell Biology, Emory University School of Medicine, Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322, USA
    J Biol Chem 281:7623-34. 2006
    b>Desmosomes are adhesive intercellular junctions prominent in the skin and heart. Loss of desmosome function is associated with severe congenital and acquired disorders characterized by tissue fragility...
  25. pmc A central role for the armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris
    R Caldelari
    Institute of Animal Pathology, University of Bern, , CH-3012 Bern, Switzerland
    J Cell Biol 153:823-34. 2001
    ....
  26. pmc Comprehensive desmosome mutation analysis in north americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy
    A Dénise den Haan
    Department of Medicine Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circ Cardiovasc Genet 2:428-35. 2009
    ..We report comprehensive desmosome genetic analysis for 100 North Americans with clinically confirmed or suspected ARVD/C...
  27. ncbi Plakoglobin: a protein common to different kinds of intercellular adhering junctions
    P Cowin
    Cell 46:1063-73. 1986
    ..We discuss the significance of this protein, for which the name plakoglobin is proposed, in terms of its interaction with such biochemically diverse membrane domains and their different types of associated cytoskeletal filaments...
  28. ncbi Desmoglein 2 is expressed abnormally rather than mutated in familial and sporadic gastric cancer
    Karin Biedermann
    Institute of Pathology, Klinikum rechts der Isar, Technische Universitat Munchen, Germany
    J Pathol 207:199-206. 2005
    ..cell adhesion molecule with functional similarity to E-cadherin is desmoglein 2 (Dsg2), a major component of the desmosomes. In this study, we investigated whether alterations of Dsg2 are involved in gastric carcinogenesis and whether ..
  29. ncbi Arrhythmogenic right ventricular dysplasia/cardiomyopathy: pathogenic desmosome mutations in index-patients predict outcome of family screening: Dutch arrhythmogenic right ventricular dysplasia/cardiomyopathy genotype-phenotype follow-up study
    Moniek G P J Cox
    Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Circulation 123:2690-700. 2011
    ..Previous genotype-phenotype relation studies involved mainly overt ARVD/C index patients, so follow-up data on relatives are scarce...
  30. pmc Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes
    Hee Jung Choi
    Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305 5126, USA
    J Biol Chem 284:31776-88. 2009
    ..Plakoglobin, but normally not beta-catenin, is also a structural constituent of desmosomes, where it binds to the cytoplasmic domains of the desmosomal cadherins, desmogleins and desmocollins...
  31. ncbi Plakophilin-1 localizes to the nucleus and interacts with single-stranded DNA
    Tammy Sobolik-Delmaire
    Department of Oral Biology, UNMC College of Dentistry, University of Nebraska Medical Center, Lincoln, Nebraska 68583 0740, USA
    J Invest Dermatol 130:2638-46. 2010
    ..These data suggest that in addition to mediating desmosome assembly, the nuclear pool of Pkp can influence cell survival by interactions with DNA...
  32. ncbi Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18
    Wera Roth
    Translational Centre for Regenerative Medicine and Institute of Biology, University of Leipzig, 04103 Leipzig, Germany
    J Cell Sci 125:5269-79. 2012
    ..Our data suggest a functional link between KRT1 and human inflammatory skin diseases...
  33. ncbi Prevalence of desmosomal protein gene mutations in patients with dilated cardiomyopathy
    Perry Elliott
    Inherited Cardiac Diseases Unit, University College London The Heart Hospital UCL Hospitals NHS trust, London, UK
    Circ Cardiovasc Genet 3:314-22. 2010
    ..The objective of this study was to determine the prevalence of mutations in 5 desmosomal protein genes in patients with dilated cardiomyopathy...
  34. ncbi Molecular genetics of arrhythmogenic right ventricular cardiomyopathy: emerging horizon?
    J Peter van Tintelen
    Departments of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Curr Opin Cardiol 22:185-92. 2007
    ..Recent developments in the elucidation of genes underlying arrhythmogenic right ventricular cardiomyopathy and possible pathogenic mechanisms will be highlighted...
  35. ncbi Desmoglein-2 and desmocollin-2 mutations in dutch arrhythmogenic right ventricular dysplasia/cardiomypathy patients: results from a multicenter study
    Zahurul A Bhuiyan
    Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Cardiovasc Genet 2:418-27. 2009
    ..We also aimed to distinguish relevant clinical and ECG parameters...
  36. pmc Arrhythmogenic right ventricular dysplasia/cardiomyopathy associated with mutations in the desmosomal gene desmocollin-2
    Petros Syrris
    Department of Medicine, University College London, United Kingdom
    Am J Hum Genet 79:978-84. 2006
    ..For the first time, we have identified mutations in desmocollin-2 in patients with ARVD/C, a finding that is consistent with the hypothesis that ARVD/C is a disease of the desmosome...
  37. ncbi Mutation analysis and evaluation of the cardiac localization of TMEM43 in arrhythmogenic right ventricular cardiomyopathy
    A H Christensen
    Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Denmark
    Clin Genet 80:256-64. 2011
    ..The immunoreactive signal for the desmosomal protein plakoglobin was reduced in mutation carriers. The TMEM43 gene underlies a distinctive form of ARVC which may share a final common pathway with desmosome-associated ARVC...
  38. ncbi Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration
    L Guo
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA
    Cell 81:233-43. 1995
    ..Unexpectedly, the mice also develop severe dystonia and sensory nerve degeneration typical of dystonia musculorum (dt/dt) mice. We show that in at least one other strain of dt/dt mice, BPAG1 gene is defective...
  39. ncbi Central role of the plakoglobin-binding domain for desmoglein 3 incorporation into desmosomes
    C D Andl
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Invest Dermatol 117:1068-74. 2001
    ..We conclude that binding of plakoglobin to desmoglein 3 is an important step in desmosome assembly and leads to the incorporation of desmoglein 3 into the desmosome...
  40. ncbi Intercellular adhering junctions with an asymmetric molecular composition: desmosomes connecting Merkel cells and keratinocytes
    Steffen Rickelt
    Helmholtz Group for Cell Biology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Cell Tissue Res 346:65-77. 2011
    ..As MCs are connected to the adjacent keratinocytes by a series of adhering junctions (AJs), of which the desmosomes are the most prominent, these junctions represent heterotypic cell-cell connections, i.e...
  41. ncbi Structure and function of hemidesmosomes: more than simple adhesion complexes
    L Borradori
    Department of Dermatology, DHURDV, University Hospital of Geneva, Switzerland
    J Invest Dermatol 112:411-8. 1999
    ..The aims of this review are to highlight the recent progresses of our knowledge on the organization and assembly of hemidesmosomes, their involvement in signaling pathways as well as their participation in clinical pathologic conditions...
  42. ncbi Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins
    S Schafer
    Division of Cell Biology, German Cancer Research Center, Heidelberg
    Exp Cell Res 211:391-9. 1994
    b>Desmosomes are junctions between epithelial, myocardiac, and certain other kinds of cells...
  43. ncbi Wide spectrum of desmosomal mutations in Danish patients with arrhythmogenic right ventricular cardiomyopathy
    A H Christensen
    Department of Cardiology, Section 2142, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    J Med Genet 47:736-44. 2010
    ..The disease has been associated with mutations in genes encoding desmosomal proteins...
  44. pmc Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy
    Deqiang Li
    Riley Heart Research Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Mol Genet 20:4582-96. 2011
    ..Ultra-structural analyses revealed that desmosomes were absent in Jup mutant myocardia, whereas adherens junctions and gap junctions were preserved...
  45. ncbi Retinoic acid disintegrated desmosomes and hemidesmosomes in stratified oral keratinocytes
    S Hatakeyama
    Department of Oral Pathology, School of Dentistry, Iwate Medical University, Morioka, Japan
    J Oral Pathol Med 33:622-8. 2004
    ..The effects of all-trans RA on cell-cell and cell-matrix connections of gingival epithelial (GE)1 cells in a multilayered culture were investigated...
  46. pmc Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells
    I Rabinovitz
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Cell Biol 146:1147-60. 1999
    ....
  47. ncbi Calcium-independent desmosomes of keratinocytes are hyper-adhesive
    Tomomi E Kimura
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    J Invest Dermatol 127:775-81. 2007
    b>Desmosomes in tissues are resistant to disruption by chelation of extracellular calcium...
  48. pmc Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis
    Kaelyn D Sumigray
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 194:631-42. 2011
    b>Desmosomes are cell-cell adhesion structures that integrate cytoskeletal networks. In addition to binding intermediate filaments, the desmosomal protein desmoplakin (DP) regulates microtubule reorganization in the epidermis...
  49. ncbi Desmosomal cadherins
    David R Garrod
    School of Biological Sciences, University of Manchester, UK
    Curr Opin Cell Biol 14:537-45. 2002
    New evidence from blocking desmosomal adhesion with anti-adhesion peptides reveals a role for desmosomes in cell positioning in morphogenesis...
  50. pmc Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling
    Jifen Li
    Center for Translational Medicine, Department of Medicine, Rm 309, College Bldg, 1025 Walnut St, Philadelphia, PA 19107, USA
    Mol Cell Biol 31:1134-44. 2011
    ..Plakoglobin is a component of both desmosomes and adherens junctions located at the intercalated disc (ICD) of cardiomyocytes, where it functions to link ..
  51. ncbi Embryonic heart and skin defects in mice lacking plakoglobin
    C Bierkamp
    Department of Molecular Embryology, Max Planck Institute for Immunobiology, Stubeweg 51, Freiburg, D 79108, Germany
    Dev Biol 180:780-5. 1996
    ..Ultrastructural analysis revealed that here desmosomes were greatly reduced in number and structurally altered...
  52. ncbi Mechanisms of plakoglobin-dependent adhesion: desmosome-specific functions in assembly and regulation by epidermal growth factor receptor
    Taofei Yin
    Department of Pathology and Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Biol Chem 280:40355-63. 2005
    ..of the Armadillo family of adhesion/signaling proteins that can be incorporated into both adherens junctions and desmosomes. Loss of PG results in defects in the mechanical integrity of heart and skin and decreased adhesive strength in ..
  53. ncbi pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion
    Jean Pierre Hachem
    University of California San Francisco Medical Center, Department of Dermatology, San Francisco, California, USA
    J Invest Dermatol 121:345-53. 2003
    ....
  54. ncbi Immunohistochemical localization of plakophilins (PKP1, PKP2, PKP3, and p0071) in primary oropharyngeal tumors: correlation with clinical parameters
    Silvana Papagerakis
    Laboratory of Biology Odontology, University of Paris VII, Paris, France
    Hum Pathol 34:565-72. 2003
    ....
  55. ncbi Differential expression of desmosomal plakophilins in various types of carcinomas: correlation with cell type and differentiation
    Juliane Schwarz
    Department of Pathology, Philipps University of Marburg Medical School, D 35033 Marburg, Germany
    Hum Pathol 37:613-22. 2006
    ..For PKP 1, a suppressor function of malignant behavior seems conceivable, whereas the putative functional significance of its occurrence in tumor cell nuclei requires further studies...
  56. ncbi Plectin deficiency results in muscular dystrophy with epidermolysis bullosa
    F J Smith
    Department of Anatomy and Physiology, Medical Sciences Institute, University of Dundee, UK
    Nat Genet 13:450-7. 1996
    ..Absence of the large multifunctional cytoskeleton protein plectin can simultaneously account for structural failure in both muscle and skin...
  57. pmc Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin
    C Ruhrberg
    Keratinocyte Laboratory, Imperial Cancer Research Fund, London WC2A 3PX, UK
    J Cell Biol 139:1835-49. 1997
    ..cultured epidermal keratinocytes revealed that envoplakin and the 195-kD protein form a network radiating from desmosomes, and we speculate that the two proteins may provide a scaffolding onto which the cornified envelope is assembled...
  58. pmc The alpha isoform of protein kinase C is involved in signaling the response of desmosomes to wounding in cultured epithelial cells
    S Wallis
    School of Biological Sciences, University of Manchester, Manchester, M13 9PT, United Kingdom
    Mol Biol Cell 11:1077-92. 2000
    ..To enhance this understanding, we focus here on changes in the adhesive state of desmosomes of cultured Madin-Darby canine kidney cells in response to wounding of confluent cell sheets...
  59. ncbi Arrhythmogenic cardiomyopathy: etiology, diagnosis, and treatment
    Srijita Sen-Chowdhry
    Imperial College, London, UK
    Annu Rev Med 61:233-53. 2010
    ..Development of a prospectively validated risk-stratification algorithm for the full disease spectrum remains the foremost clinical challenge...
  60. pmc A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development
    D Riethmacher
    Max Delbrueck Laboratorium, Max Planck Gesellschaft, Koeln, Germany
    Proc Natl Acad Sci U S A 92:855-9. 1995
    ..Interestingly, the blastomers are still able to form desmosomes and tight junctions at sites of distorted cell-cell contact...
  61. ncbi Arrhythmogenic right ventricular cardiomyopathy plakophilin-2 mutations disrupt desmosome assembly and stability
    Chad Hall
    Department of Oral Biology, University of Nebraska Medical Center College of Dentistry, Lincoln, Nebraska 68583, USA
    Cell Commun Adhes 16:15-27. 2009
    ..b>Desmosomes are prominent cell-cell junctions found in a variety of tissues that resist mechanical stress, including the ..
  62. ncbi Mechanisms of desmosome assembly and disassembly
    Y Kitajima
    Department of Dermatology, Gifu University School of Medicine, Gifu City, Japan
    Clin Exp Dermatol 27:684-90. 2002
    In skin, desmosomes constitute critical adhesion complexes between adjacent keratinocytes that help maintain an intact epidermis...
  63. pmc JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration
    Ke Zen
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Mol Biol Cell 15:3926-37. 2004
    ..Here, we demonstrate that JAM-C is abundantly expressed basolaterally in intestinal epithelia and localizes to desmosomes but not tight junctions...
  64. ncbi New insights into desmosome regulation and pemphigus blistering as a desmosome-remodeling disease
    Yasuo Kitajima
    Department of Dermatology, Kizawa Memorial Hospital, Professor Emeritus Gifu University School of Medicine, Minokamo City, Gifu, Japan
    Kaohsiung J Med Sci 29:1-13. 2013
    b>Desmosomes in keratinocytes are the most important intercellular adhering junctions that provide structural strength for the epidermis. These junctions are connected directly with desmosomal cadherin proteins...
  65. ncbi Clinical and genetic characterization of families with arrhythmogenic right ventricular dysplasia/cardiomyopathy provides novel insights into patterns of disease expression
    Srijita Sen-Chowdhry
    The Heart Hospital, University College London, United Kingdom
    Circulation 115:1710-20. 2007
    ..We hypothesized that unbiased representation of the spectrum of disease expression in arrhythmogenic right ventricular dysplasia/cardiomyopathy would require in vivo assessment of families in a genetically heterogeneous population...
  66. ncbi A perspective of pemphigus from bedside and laboratory-bench
    Yasuo Kitajima
    Department of Dermatology, Gifu University School of Medicine, Gifu City, Japan
    Clin Rev Allergy Immunol 33:57-66. 2007
    ..and may, in turn, lead to internalization of desmogleins and inhibition of desmogleins' integration into desmosomes, resulting in the formation of Dsg3-depleted desmosomes in PV or Dsg1-depleted desmosomes in PF...
  67. ncbi Order and disorder in corneocyte adhesion
    Akemi Ishida-Yamamoto
    Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan
    J Dermatol 38:645-54. 2011
    Epidermal cornified cells are attached to each other with modified desmosomes, namely corneodesmosomes...
  68. ncbi The DSPII splice variant is crucial for desmosome-mediated adhesion in HaCaT keratinocytes
    Rita M Cabral
    Centre for Cutaneous Research, The Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK
    J Cell Sci 125:2853-61. 2012
    b>Desmosomes are intercellular junctions specialised for strong adhesion that are prominent in the epidermis and heart muscle...
  69. pmc Nomenclature of the desmosomal cadherins
    R S Buxton
    Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, Mill Hill, London, United Kingdom
    J Cell Biol 121:481-3. 1993
  70. ncbi IgG-induced clustering of desmogleins 1 and 3 in skin of patients with pemphigus fits with the desmoglein nonassembly depletion hypothesis
    D A M Oktarina
    Department of Dermatology, Centre for Blistering Diseases, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Br J Dermatol 165:552-62. 2011
    ..In pemphigus circulating IgG is present with the desmosomal cadherins desmoglein (Dsg) 1 and 3. In the epidermis of patients, this IgG deposits in a pattern that is often partly granular and does not reflect the normal Dsg distribution...
  71. ncbi Immunological identification and characterization of the desmosomal cadherin Dsg2 in coupled and uncoupled epithelial cells and in human tissues
    S Schafer
    Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany
    Differentiation 60:99-108. 1996
    ..the dendritic reticulum of lymph node follicles, are interconnected by numerous intercellular junctions termed desmosomes. These are characterized by a set of transmembrane glycoproteins, i.e...
  72. ncbi Intercalated disc abnormalities, reduced Na(+) current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes
    Stefania Rizzo
    Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua 35121, Italy
    Cardiovasc Res 95:409-18. 2012
    ..We investigated whether mutation-induced intercalated disc remodelling impacts on electrophysiological properties before the onset of cell death and replacement fibrosis...
  73. ncbi Direct evidence that PKCα positively regulates wound re-epithelialization: correlation with changes in desmosomal adhesiveness
    Helen A Thomason
    Faculty of Life Sciences, University of Manchester, UK
    J Pathol 227:346-56. 2012
    ..We demonstrate mechanistic conservation in acute human wounds where PKCα localizes to wound edge desmosomes, which become Ca(2+) -dependent...
  74. pmc The three-dimensional molecular structure of the desmosomal plaque
    Ashraf Al-Amoudi
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Proc Natl Acad Sci U S A 108:6480-5. 2011
    ..We used cryoelectron tomography of vitreous sections from human epidermis to record 3D images of desmosomes in vivo and in situ at molecular resolution...
  75. pmc Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium
    Andrew J Ewald
    Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Sci 125:2638-54. 2012
    ..Instead, interior cells were connected through desmosomes and exhibited complex interdigitating membrane protrusions...
  76. ncbi Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice
    R van der Neut
    Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Nat Genet 13:366-9. 1996
    ..No evidence was found for impaired T-cell development, nor for defects in myelination in the peripheral nervous system...
  77. pmc Desmosome dynamics in migrating epithelial cells requires the actin cytoskeleton
    Brett J Roberts
    The University of Nebraska Medical Center College of Dentistry, Lincoln, NE 68583, USA
    Exp Cell Res 317:2814-22. 2011
    ..b>Desmosomes are prominent adhesive structures found in a variety of epithelial tissues that are believed to inhibit cell ..
  78. pmc Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes
    Oxana E Nekrasova
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Cell Biol 195:1185-203. 2011
    ..desmogleins (Dsgs) and desmocollins (Dscs), comprise the adhesive core of intercellular junctions known as desmosomes. Although these adhesion molecules are known to be critical for tissue integrity, mechanisms that coordinate ..
  79. pmc The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome
    S B Hopkinson
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Mol Biol Cell 11:277-86. 2000
    ..These data provide new insight into those interactions of the molecules of the hemidesmosome that are necessary for its function in integrating epithelial and connective tissue types...
  80. pmc Periplakin gene targeting reveals a constituent of the cornified cell envelope dispensable for normal mouse development
    Sirpa Aho
    Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Cell Biol 24:6410-8. 2004
    ..e., desmosomes and hemidesmosomes, respectively. Periplakin is a recently characterized member of this family...
  81. ncbi Multiple mutations in desmosomal proteins encoding genes in arrhythmogenic right ventricular cardiomyopathy/dysplasia
    Barbara Bauce
    Department of Cardiac Thoracic and Vascular Sciences, University of Padua Medical School, Padua, Italy
    Heart Rhythm 7:22-9. 2010
    ..Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a progressive cardiomyopathy showing a wide clinical spectrum in terms of clinical expressions and prognoses...
  82. pmc A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions
    Katja Gehmlich
    Institute of Cardiovascular Science, University College London, and The Heart Hospital, London, United Kingdom
    Heart Rhythm 8:711-8. 2011
    Cellular adhesion mediated by cardiac desmosomes is a prerequisite for proper electric propagation mediated by gap junctions in the myocardium. However, the molecular principles underlying this interdependence are not fully understood.
  83. pmc Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane
    Karen R Groot
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Cell Biol 166:653-9. 2004
    ..Kazrin colocalizes with periplakin and desmoplakin at desmosomes and with periplakin at the interdesmosomal plasma membrane, but its subcellular distribution is independent of ..
  84. ncbi Frameshift mutation in the V2 domain of human keratin 1 results in striate palmoplantar keratoderma
    Neil V Whittock
    Epithelial Genetics Group, Human Genetics Unit, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    J Invest Dermatol 118:838-44. 2002
    ..Using expression studies we show that the V2 domain is essential for normal function of keratin intermediate filaments...
  85. ncbi Patterns of desmocollin synthesis in human epithelia: immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells
    U A Nuber
    Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany
    Eur J Cell Biol 71:1-13. 1996
    ..Dsc3, but not Dsc1, it also present in desmosomes of the basal as well as suprabasal cell layers of other stratified epithelia such as vagina, tongue and ..
  86. ncbi Evidence for a role of corneodesmosin, a protein which may serve to modify desmosomes during cornification, in stratum corneum cell cohesion and desquamation
    A Lundstrom
    Department of Dermatology, University Hospital, Umea, Sweden
    Arch Dermatol Res 286:369-75. 1994
    ..In the stratum corneum it is localized in the extracellular parts of modified desmosomes (corneodesmosomes) and adjacent parts of the cornified cell envelope...
  87. pmc Membrane-impermeable cross-linking provides evidence for homophilic, isoform-specific binding of desmosomal cadherins in epithelial cells
    Zhuxiang Nie
    Faculty of Life Science, University of Manchester, Manchester M13 9PT, United Kingdom
    J Biol Chem 286:2143-54. 2011
    b>Desmosomes and adherens junctions are cadherin-based protein complexes responsible for cell-cell adhesion of epithelial cells...
  88. pmc Molecular genetic studies of a human epidermal autoantigen (the 180-kD bullous pemphigoid antigen/BP180): identification of functionally important sequences within the BP180 molecule and evidence for an interaction between BP180 and alpha 6 integrin
    S B Hopkinson
    Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Cell Biol 130:117-25. 1995
    ..Perturbation of this latter domain by human bullous pemphigoid autoantibodies may explain the loss of epidermal cell-dermis attachment that characterizes the BP disease...
  89. ncbi PKP2 mutations in sudden death from arrhythmogenic right ventricular cardiomyopathy (ARVC) and sudden unexpected death with negative autopsy (SUDNA)
    Mingchang Zhang
    Department of Forensic Medicine, Shanghai Medical College, Fudan University, Shanghai, China
    Circ J 76:189-94. 2012
    ..Fatal arrhythmias resulting in sudden death also occur in the absence of morphologic cardiac abnormalities at autopsy, and have been linked to ion channel mutations in a subset of cases, but so far not to PKP2...
  90. ncbi Guidelines for the diagnosis and management of arrhythmogenic right ventricular cardiomyopathy
    Warren Smith
    Green Lane Cardiovascular Service, Cardiology Department, Auckland City Hospital, Private Bag 92024, Auckland, New Zealand
    Heart Lung Circ 20:757-60. 2011
    ..It most commonly presents with palpitations or syncope but sudden death may occur, especially in young males...
  91. ncbi The alpha3 laminin subunit, alpha6beta4 and alpha3beta1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin
    L E Goldfinger
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA
    J Cell Sci 112:2615-29. 1999
    ..We propose a model for healing of wounded epithelial tissues based on these results...
  92. ncbi Binding of pemphigus vulgaris IgG to antigens in desmosome core domains excludes immune complexes rather than directly splitting desmosomes
    Y Aoyama
    Department of Dermatology, Okayama Rosai Hospital and Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Br J Dermatol 162:1049-55. 2010
    ..Pemphigus vulgaris (PV) is characterized by autoantibodies against desmoglein (Dsg) 3 or both Dsg1 and Dsg3, i.e. desmosomal adhesion molecules...
  93. ncbi The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery
    Nicola Cirillo
    Center on Craniofacial Malformations MRI, Regione Campania, 1st School of Medicine and Surgery, II University of Naples, 80138 Naples, Italy
    J Cell Biochem 103:598-606. 2008
    ..Furthermore, cells pretreated with z-DEVD-fmk retained the membrane labeling of Dsg2. Taken together, our data demonstrate that the apoptotic processing of Dsg2 is mediated by caspase 3 in epithelial cells...
  94. pmc EGFR and ADAMs cooperate to regulate shedding and endocytic trafficking of the desmosomal cadherin desmoglein 2
    Jodi L Klessner
    Departments of Pathology and Dermatology, and the R H Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Biol Cell 20:328-37. 2009
    ....
  95. ncbi Continual assembly of desmosomes within stable intercellular contacts of epithelial A-431 cells
    Natalia A Gloushankova
    Cancer Research Center of the Russian Federation, Moscow, Russia
    Cell Tissue Res 314:399-410. 2003
    ..and either human desmoglein 2 (Dsg-GFP) or human plakoglobin (GFP-Pg) were used to examine the behavior of desmosomes in living cells...
  96. ncbi Molecular biology and clinical management of arrhythmogenic right ventricular cardiomyopathy/dysplasia
    Domenico Corrado
    Inherited Arrhythmogenic Cardiomyopathy Unit, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua Medical School, Padua, Italy
    Heart 97:530-9. 2011
    ..insights into our understanding of the disease aetiology by showing that it is a genetic disorder of the cardiac desmosomes and that interactions between mechanical disruption of cell-cell adhesion and defects of desmosomal-mediated ..
  97. pmc Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations
    Katja Gehmlich
    Institute of Cardiovascular Science, University College London, London, UK
    Cardiovasc Res 90:77-87. 2011
    ..However, the underlying molecular processes are poorly understood...
  98. pmc Sec3-containing exocyst complex is required for desmosome assembly in mammalian epithelial cells
    Nicholas J Andersen
    Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Mol Biol Cell 21:152-64. 2010
    ..evidence in support of a function for a Sec3-containing Exocyst complex in the assembly or maintenance of desmosomes, adhesive junctions that link intermediate filament networks to sites of strong intercellular adhesion...
  99. ncbi Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells
    S Bonne
    Molecular Cell Biology Unit, Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology VIB University of Gent, Ledeganckstraat 35, B 9000 Gent, Belgium
    J Cell Sci 112:2265-76. 1999
    ..By immunofluorescence, the plakophilin-3 protein was colocalized with desmoglein in desmosomes of epithelial cells. In addition, an intriguing speckle-like nuclear staining was observed...
  100. ncbi Population-prevalent desmosomal mutations predisposing to arrhythmogenic right ventricular cardiomyopathy
    Annukka M Lahtinen
    Research Program for Molecular Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Heart Rhythm 8:1214-21. 2011
    ..Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a progressive myocardial disorder caused by mutations of desmosomal cell adhesion proteins. The prevalence of these variants in the general population is unknown...
  101. pmc Junctional music that the nucleus hears: cell-cell contact signaling and the modulation of gene activity
    Pierre D McCrea
    Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Program in Genes and Development, University of Texas Graduate School of Biomedical Sciences, Houston, Texas 77030, USA
    Cold Spring Harb Perspect Biol 1:a002923. 2009
    ..This review assesses a variety of cell-cell junction-to-nuclear signaling pathways, and outlines interesting areas for further study...

Research Grants62

  1. Biology of desmosome-gap junctions in the testis
    Dolores D Mruk; Fiscal Year: 2010
    ..biology is the adhesion of cells to form an organized epithelium, which is facilitated by adherens junctions and desmosomes. In the testis, morphological studies in the 1970s reported the presence of desmosome-gap junctions (also known ..
  2. Disease Mechanisms in ARVC
    Jeffrey E Saffitz; Fiscal Year: 2013
    ..hypothesis that mechanical stress, such as might occur following strenuous or prolonged exercise, destabilizes desmosomes in the heart (especially in the right ventricle) which leads to increased cytoplasmic concentrations of ..
  3. ADHESION JUNCTION REGULATION IN NORMAL AND DISEASED SKIN
    David S Rubenstein; Fiscal Year: 2012
    ..This process culminates in the destabilization of desmosomes, retraction of keratin intermediate filaments and alterations to the actin cytoskeleton, which collectively ..
  4. REGULATION AND FUNCTION OF KERATINS IN THE EPIDERMIS
    DENNIS ROOP; Fiscal Year: 2010
    ..In vitro studies have suggested that these domains interact with desmosomes and/or the cell envelope, however very little is known regarding cell type-specific functions of these domains ..
  5. CATENINS, CADHERINS AND THEIR INTERACTIONS
    William I Weis; Fiscal Year: 2012
    ..the catenins link transmembrane cadherin cell adhesion molecules to the actin-based cytoskeleton, and in desmosomes an analogous protein assembly links cadherins to intermediate filaments...
  6. NIDCR Dentist Scientist K99;Function and Regulation of Perp in Amelogenesis
    Andrew H Jheon; Fiscal Year: 2013
    ..P53-effector related to PMP-22) is a membrane protein that plays an essential role in the stable assembly of desmosomes, which are cell-cell adhesion macromolecules central to epithelial integrity and homeostasis...
  7. NIDCR Dentist Scientist K99;Function and Regulation of Perp in Amelogenesis
    Andrew H Jheon; Fiscal Year: 2012
    ..P53-effector related to PMP-22) is a membrane protein that plays an essential role in the stable assembly of desmosomes, which are cell-cell adhesion macromolecules central to epithelial integrity and homeostasis...
  8. Role of Desmosomal Adhesion in Carcinogenesis
    MY GEORGIA MAHONEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Desmosomes are intercellular adhesive junctions that play pivotal roles in maintaining tissue architecture, integrity and function...
  9. Cross-talk Between Desmosomal Proteins and Signaling Pathways in the Skin
    Peter J Koch; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Desmosomes are highly dynamic cell-cell adhesion complexes that have the ability to adjust their adhesive properties and molecular composition, thereby affecting cell migration, cell sorting and cell ..
  10. Role of cell adhesion in organizing membrane growth.
    CHARLES A YEAMAN; Fiscal Year: 2013
    ..manner during the formation of specialized membrane domains-including the apical junctional complex, desmosomes and primary cilia...
  11. Desmosomal Control of Cytoskeletal Organization
    Terry H Lechler; Fiscal Year: 2013
    b>Desmosomes are essential cell-cell adhesion structures that provide mechanical integrity to tissues...
  12. Mechanisms enhancing functional coupling between native and embryonic stem cell d
    Karen Maass; Fiscal Year: 2013
    ..Cell contacts provide structural tissue support (mechanical junctions: adherens junctions;desmosomes) and allow fast impulse propagation and the synchronous contraction of the heart muscle (electrical junctions: ..
  13. In Vitro Human Tissue Model for Intravaginal Drug Delivery
    Seyoum Ayehunie; Fiscal Year: 2010
    ..resistance), and the presence of organelles important in determining mucosal barrier properties such as desmosomes and tight junctions. In addition, the levels of barrier lipids will be quantified...
  14. Mechanisms of Desmosome Regulation and Disassembly in the Skin Disease Pemphigus
    Andrew P Kowalczyk; Fiscal Year: 2012
    ..Pemphigus IgG target desmosomes, a structure that couples the keratin intermediate filament network to regions of strong cell-cell adhesion...
  15. Desmoplakin Assembly and Function in Epidermis
    KATHLEEN JANEE GREEN; Fiscal Year: 2013
    ..The mechanisms by which desmosomes govern signaling pathways to control tissue homeostasis and disease pathogenesis are poorly understood...
  16. Genetics, Mechanisms and Clinical Phenotypes of Arrhythmogenic Cardiomyopathy
    Wojciech Zareba; Fiscal Year: 2013
    ..proteins of the desmosome/cell-cell junction pathway (or its binding partners), leads to destabilization of desmosomes and disruption of the intercalated disk and inflammation, and impairs Wnt signaling pathways by changing the ..
  17. Cytokine induction of Claudin-1 in epicardial border zone of ischemic heart
    Heather S Duffy; Fiscal Year: 2010
    ..cell-cell junctions allow for close membrane apposition (via adherens junctions) that are very stable (via desmosomes) and support the formation of electrical junctions (gap junctions)...
  18. Adhesion Molecules of the Intercalated Disc in Cardiomyopathy
    Kirk U Knowlton; Fiscal Year: 2011
    ..of an array of proteins, which are categorized into three major junctional complexes, fascia adherens junctions, desmosomes, and gap junctions, and are essential for maintaining mechanical and electrical coupling between neighboring ..
  19. Intestinal Epithelial Tight Junction Structure-Function
    Asma Nusrat; Fiscal Year: 2013
    ..by a series of intercellular junctions that encompass the tight junction (TJ), adherens junction (AJ) and desmosomes (DMs)...
  20. Role of Desmosomes in Cardiac Electrical Function
    Mario Delmar; Fiscal Year: 2013
    ..abstract_text> ..
  21. Xenobiotics and Breast Epithelial Cell-ECM Signaling
    Raymond Novak; Fiscal Year: 2005
    ..Other types of structures that link cells to each other or to the ECM include adherens junctions and desmosomes. Because correct issue architecture and cell morphology are critical for cellular homeostasis, we have examined ..
  22. Desmoglein 2 Function in Cell Adhesion and Pemphigus
    MY MAHONEY; Fiscal Year: 2003
    Epidermal keratinocytes are held together by intercellular junctions called desmosomes, which are critical for the maintenance of cell-cell adhesion, tissue integrity, and organ function...
  23. PATHOPHYSIOLOGY OF EXPERIMENTALLY INDUCED PEMPHIGUS
    Grant Anhalt; Fiscal Year: 1993
    ..lesions in vivo by passive transfer into mice; (4) the tumor (a reticulum cell sarcoma) from one case possesses desmosomes and expresses desmoplakin I, that is reactive with both a monoclonal antibody against desmoplakin and the ..
  24. ADHESION MOLECULES AND EPIDERMAL STRATIFICATION
    ROBERT LAVKER; Fiscal Year: 2001
    ..Cell to cell adhesion is essential in this process. Although desmosomes apparently provide the mechanical strength in adhesion, adherens junctions provide the specificity, and are ..
  25. Communication Between Laminin 5 and Gap Junctions
    William Carter; Fiscal Year: 2005
    ..interactions are mediated by at least three types of intercellular junctions: adherens junctions (AJs), desmosomes and gap junctions (GJs). Connexin 43 (Cx43) is the predominant constituent of GJs in the epidermis...
  26. Delta Vision-OMX Super-Resolution Fluorescent Microscope
    Thomas Hope; Fiscal Year: 2012
    ..the OMX can deliver new insights into the spatial details of such structures including the nuclear lamins, desmosomes, and intracellular viral complexes...
  27. ANTIGENS RECOGNIZED BY PEMPHIGUS AUTOANTIBODIES
    Robert Goldman; Fiscal Year: 1990
    ..that pemphigus patients contain circulating autoantibodies directed against components associated with the desmosomes of stratified epithelial tissues...
  28. DESMOSOMES--STRUCTURE/FUNCTION
    EDWARD O KEEFE; Fiscal Year: 2000
    Two types of epithelial cell-cell junctions, desmosomes and adherens junctions, are important in maintaining the integrity of epithelium...
  29. PHYSIOLOGICAL STUDIES ON MAMMALIAN TONGUE
    SIDNEY SIMON; Fiscal Year: 1990
    ..e., tight junctions, desmosomes, gap junctions)...
  30. MODULATION OF GENE EXPRESSION IN CELL CULTURE
    RODY COX; Fiscal Year: 1980
    ..The morphological differentiation consists of the development of specialized intercellular junctions - desmosomes and the organization of microfilaments into tonofilaments which resemble those found in squamous epithelium...
  31. GROWTH FACTOR MODULATION OF REEPITHELIALIZATION
    LAURIE HUDSON; Fiscal Year: 2004
    ..These include retraction of intermediate filaments from the cell surface, dissolution of most desmosomes and hemidesmosomes and partial or complete dissolution of the basement membrane...
  32. ANALYSES OF EPITHELIUM FORMATION
    Eileen Adamson; Fiscal Year: 1990
    ..is also to be studied; that is, the role of cellular interactions in the form of junctional complexes and desmosomes. We hope to correlate observations using biosynthetic measurements, immunological techniques and electron ..
  33. HUMAN DESMOPLAKIN GENE STRUCTURE & EXPRESSION IN EMBRYOS
    Kathleen Green; Fiscal Year: 1990
    ..b>Desmosomes also appear to act as specific attachment sites for intermediate filaments (IF)...
  34. REGULATION AND FUNCTION OF KERATINS IN THE EPIDERMIS
    DENNIS ROOP; Fiscal Year: 2003
    ..In vitro studies have suggested that these domains interact with desmosomes and/or the cell envelope, however these interactions have not been confirmed by in vivo models...
  35. ANTI-DESMOSOMAL ANTIBODIES IN PERIODONTITIS
    YAKOV GOVZE; Fiscal Year: 1993
    The glycoproteins, desmogleins 2 and 3 (desmocollins) are integral to the formation, assembly and stability of desmosomes. The formation of desmosomes is inhibited by Fab fragments of antibodies against desmogleins 2 and 3...
  36. DESMOCOLLIN 1 IN EPIDERMAL DEVELOPMENT & HOMEOSTASIS
    Peter Koch; Fiscal Year: 2005
    DESCRIPTION: (verbatim) -- Desmosomes are cell adhesion structures (junctions) that are particularly abundant in the epidermis...
  37. CELL ADHESION AND REGULATION OF CARDIAC MYOCYTE FUNCTION
    Glenn Radice; Fiscal Year: 2001
    ..the ability of cardiac myocytes from N-cadherin-deficient transgenic mouse embryos to assemble gap junctions and desmosomes. The expression and cellular localization of contractile proteins will also be examined in N-cadherin-minus ..
  38. CONFOCAL LASER SCAN MICROSOCPE
    Robert Goldman; Fiscal Year: 1990
    ..3) The structure, function and assembly of hemidesmosomes and desmosomes in mammalian cells and tissues (Jones)...
  39. Role of Vinculin in Epithelial Cell Junctions
    Kris DeMali; Fiscal Year: 2009
    ..proteins that assemble into a variety of structures such as gap junctions, tight junctions, adherens junctions, desmosomes and hemidesmosomes, each with a different function...
  40. Modulators of EMT in Skin Carcinogenesis
    Donna Kusewitt; Fiscal Year: 2006
    ..The process of EMT requires loss of cell:cell adhesion mediated by desmosomes and increased secretion of extracellular matrix-degrading proteases...
  41. Exfoliative toxin A and desmosomal adhesion in epidermis
    CORY SIMPSON; Fiscal Year: 2009
    ..b>Desmosomes are crucial for cell:cell adhesion in tissues enduring stress, such as the epidermis...
  42. NORAN OZ CONFOCAL LASER SCANNING SYSTEM
    Joseph Mazurkiewicz; Fiscal Year: 1999
    ..distribution with relationship to one another, to cell junctions (tight junctions, adherens junctions, and hemi-desmosomes) or cell-matrix interactions at integrin-cytoskeleton-matrix proteins, subsequent to a variety of stimuli, ..
  43. A New Role for Desmoplakin in Signaling.
    Angel Miera; Fiscal Year: 2007
    ..by applicant): For 30 years the canonical function for desmoplakin has been to link intermediate filaments to desmosomes. This function has been confirmed by traditional knockouts and tissue specific knockouts...
  44. PATHWAYS AND MECHANISMS CONTROLLING EARLY ORAL NEOPLASIA
    Jonathan Garlick; Fiscal Year: 2005
    ..dominant negative forms of E-cadherin (Aim 3) and desmosomal cadherins (Aim 4) to disrupt adherens junctions and desmosomes, respectively...
  45. BIOLOGY OF THE CUTANEOUS EPITHELIUM
    William Parks; Fiscal Year: 2002
    ..The molecular determinants required for formation of desmosomes and their role in keratinocyte signaling and epidermal morphogenesis will be addressed by Dr...
  46. Epithelial polarity during skin regeneration
    Danelle Devenport; Fiscal Year: 2007
    ..in epithelial sheets with particular focus on the structure, composition and dynamics of adherens junctions, desmosomes, actin and microtubule-based cytoskeletons and apical and basal membrane domains...
  47. PROFILAGGRIN IN EPIDERMAL DIFFERENTIATION AND FUNCTION
    RICHARD PRESLAND; Fiscal Year: 2002
    ....
  48. HEMIDESMOSOMAL PROTEIN LINKAGE MAP BY TWO-HYBRID SYSTEM
    Sirpa Aho; Fiscal Year: 2002
    ..abstract_text> ..
  49. Epithelial Differentiation and Keratinization Gordon Con
    Kathleen Green; Fiscal Year: 2003
    ..Funds are requested to support conference fees, and travel expenses of the participants. (ie. speakers, chairpersons, graduate students, and post docs. ..
  50. CX43 IN A GENETIC MODEL OF ALTERED MYOCARDIAL CONDUCTION
    Jeffrey Saffitz; Fiscal Year: 2004
    ..The results of the proposed research will define mechanisms by which reduced coupling promotes ventricular tachyarrhythmias in mouse models of acute and chronic ischemic heart disease in patients. ..
  51. REGULATION OF MYOCARDIAL GAP JUNCTIONS
    Jeffrey Saffitz; Fiscal Year: 2006
    ..abstract_text> ..
  52. Protease-Mediated Events in Epidermal Differentiation
    RICHARD PRESLAND; Fiscal Year: 2006
    ..abstract_text> ..
  53. Desmoplakin Assembly and Function in Epidermis
    KATHLEEN JANEE GREEN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Desmoplakin (DP) is the most abundant component of desmosomes, intercellular junctions required for maintaining tissue integrity in embryos and adults...
  54. INTERCADHERIN INTERACTIONS IN DESMOSOMES
    Sergey Troyanovsky; Fiscal Year: 2008
    ..Two factors - the complexity of desmosome cadherin composition and the insolubility of desmosomes - have hampered direct examination of protein-protein interactions in these structures...
  55. Regulation of Keratinocyte Migration by Acetylcholine
    Sergei A Grando; Fiscal Year: 2010
    ..This study will identify potential therapeutic agents among cholinergic drugs acting upon specific types of ACh receptors to activate signaling pathways mediating keratinocyte functions during wound epithelialization. ..
  56. Can nicotinic antagonists prevent tobacco smoke-induced*
    SERGEI GRANDO; Fiscal Year: 2006
    ....
  57. Nicotinic receptor-mediated action of tobacco nitrosamines on respiratory cells
    SERGEI GRANDO; Fiscal Year: 2007
    ..These findings will open a door for future mechanistic studies of the intracellular signaling pathways mediating the carcinogenic and tumor-promoting actions of tobacco nitrosamines. [unreadable] [unreadable] [unreadable]..
  58. Role of Plakophilin-1 in HNSCC
    James Wahl; Fiscal Year: 2009
    ..Defining the nuclear function of plakophilin-1 will lay the ground work for identifying new prognostic markers for HNSCC and also potential targets for novel therapeutic strategies for treating the disease. ..
  59. Molecular Genetics of Familial Tumoral Calcinosis
    Jouni Uitto; Fiscal Year: 2009
    ..abstract_text> ..
  60. GENETIC ANALYSIS OF ALOPECIA AREATA
    Angela Christiano; Fiscal Year: 2009
    ..We anticipate these studies will provide a foundation for understanding the interactions of these genes with each other and with other variables such as the immune system. ..