hematopoietic stem cells

Summary

Summary: Progenitor cells from which all blood cells derive.

Top Publications

  1. ncbi SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
  2. ncbi A lineage of myeloid cells independent of Myb and hematopoietic stem cells
    Christian Schulz
    Centre for Molecular and Cellular Biology of Inflammation, New Hunt s House, King s College London, Great Maze Pond, London SE1 1UL, UK
    Science 336:86-90. 2012
  3. pmc Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
    Simon Mendez-Ferrer
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 466:829-34. 2010
  4. pmc Hematopoiesis: an evolving paradigm for stem cell biology
    Stuart H Orkin
    Division of Hematology Oncology, Children s Hospital Boston and the Dana Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 132:631-44. 2008
  5. ncbi Osteoblastic cells regulate the haematopoietic stem cell niche
    L M Calvi
    Endocrine Unit, Department of Medicine, Center for Human Genetics and Molecular Pediatric Disease, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Nature 425:841-6. 2003
  6. pmc Endothelial and perivascular cells maintain haematopoietic stem cells
    Lei Ding
    Howard Hughes Medical Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 481:457-62. 2012
  7. ncbi Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy
    Nathalie Cartier
    INSERM UMR745, University Paris Descartes, 75279 Paris, France
    Science 326:818-23. 2009
  8. ncbi FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
    Zuzana Tothova
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 128:325-39. 2007
  9. ncbi LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    S Hacein-Bey-Abina
    INSERM Unit 429, Cedex 15, France
    Science 302:415-9. 2003
  10. ncbi Mutation in TET2 in myeloid cancers
    Francois Delhommeau
    INSERM U790, Institut Gustave Roussy, Villejuif, France
    N Engl J Med 360:2289-301. 2009

Detail Information

Publications363 found, 100 shown here

  1. ncbi SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
    To improve our ability to identify hematopoietic stem cells (HSCs) and their localization in vivo, we compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors (MPPs)...
  2. ncbi A lineage of myeloid cells independent of Myb and hematopoietic stem cells
    Christian Schulz
    Centre for Molecular and Cellular Biology of Inflammation, New Hunt s House, King s College London, Great Maze Pond, London SE1 1UL, UK
    Science 336:86-90. 2012
    ..dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive HSCs...
  3. pmc Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
    Simon Mendez-Ferrer
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 466:829-34. 2010
    ..These results uncover an unprecedented partnership between two distinct somatic stem-cell types and are indicative of a unique niche in the bone marrow made of heterotypic stem-cell pairs...
  4. pmc Hematopoiesis: an evolving paradigm for stem cell biology
    Stuart H Orkin
    Division of Hematology Oncology, Children s Hospital Boston and the Dana Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 132:631-44. 2008
    Establishment and maintenance of the blood system relies on self-renewing hematopoietic stem cells (HSCs) that normally reside in small numbers in the bone marrow niche of adult mammals...
  5. ncbi Osteoblastic cells regulate the haematopoietic stem cell niche
    L M Calvi
    Endocrine Unit, Department of Medicine, Center for Human Genetics and Molecular Pediatric Disease, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Nature 425:841-6. 2003
    ..Niche constituent cells or signalling pathways provide pharmacological targets with therapeutic potential for stem-cell-based therapies...
  6. pmc Endothelial and perivascular cells maintain haematopoietic stem cells
    Lei Ding
    Howard Hughes Medical Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 481:457-62. 2012
    ..Most HSCs were lost when Scf was deleted from both endothelial and Lepr-expressing perivascular cells. Thus, HSCs reside in a perivascular niche in which multiple cell types express factors that promote HSC maintenance...
  7. ncbi Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy
    Nathalie Cartier
    INSERM UMR745, University Paris Descartes, 75279 Paris, France
    Science 326:818-23. 2009
    ..These results strongly suggest that hematopoietic stem cells were transduced in the patients...
  8. ncbi FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
    Zuzana Tothova
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 128:325-39. 2007
    ..Thus, FoxO proteins play essential roles in the response to physiologic oxidative stress and thereby mediate quiescence and enhanced survival in the HSC compartment, a function that is required for its long-term regenerative potential...
  9. ncbi LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    S Hacein-Bey-Abina
    INSERM Unit 429, Cedex 15, France
    Science 302:415-9. 2003
    ..Thus, retrovirus vector insertion can trigger deregulated premalignant cell proliferation with unexpected frequency, most likely driven by retrovirus enhancer activity on the LMO2 gene promoter...
  10. ncbi Mutation in TET2 in myeloid cancers
    Francois Delhommeau
    INSERM U790, Institut Gustave Roussy, Villejuif, France
    N Engl J Med 360:2289-301. 2009
    ..The myelodysplastic syndromes and myeloproliferative disorders are associated with deregulated production of myeloid cells. The mechanisms underlying these disorders are not well defined...
  11. ncbi Stem cell gene expression programs influence clinical outcome in human leukemia
    Kolja Eppert
    Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research, Ontario Cancer Institute, University Health Network and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Nat Med 17:1086-93. 2011
    ..Thus, determinants of stemness influence the clinical outcome of AML, establishing that LSCs are clinically relevant and not artifacts of xenotransplantation...
  12. ncbi Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
    Anne Wilson
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland
    Cell 135:1118-29. 2008
    Bone marrow hematopoietic stem cells (HSCs) are crucial to maintain lifelong production of all blood cells...
  13. ncbi Identification of the haematopoietic stem cell niche and control of the niche size
    Jiwang Zhang
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Nature 425:836-41. 2003
    ..We conclude that SNO cells lining the bone surface function as a key component of the niche to support HSCs, and that BMP signalling through BMPRIA controls the number of HSCs by regulating niche size...
  14. ncbi A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    K Akashi
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Nature 404:193-7. 2000
    ....
  15. ncbi Wnt proteins are lipid-modified and can act as stem cell growth factors
    Karl Willert
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 423:448-52. 2003
    ..The purified Wnt3a protein induces self-renewal of haematopoietic stem cells, signifying its potential use in tissue engineering...
  16. ncbi MicroRNAs modulate hematopoietic lineage differentiation
    Chang Zheng Chen
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 303:83-6. 2004
    ..Our results indicate that microRNAs are components of the molecular circuitry that controls mouse hematopoiesis and suggest that other microRNAs have similar regulatory roles during other facets of vertebrate development...
  17. ncbi IFNalpha activates dormant haematopoietic stem cells in vivo
    Marieke A G Essers
    Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum DKFZ, DKFZ ZMBH Alliance, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nature 458:904-8. 2009
    ..These data may help to clarify the so far unexplained clinical effects of IFNalpha on leukaemic cells, and raise the possibility for new applications of type I interferons to target cancer stem cells...
  18. ncbi Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors
    Jalees Rehman
    Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    Circulation 107:1164-9. 2003
    ..It is not known whether the proangiogenic effects are a result of such events as endothelial differentiation and subsequent proliferation of EPCs or secondary to secretion of angiogenic growth factors...
  19. pmc Dnmt3a is essential for hematopoietic stem cell differentiation
    Grant A Challen
    Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, Texas, USA
    Nat Genet 44:23-31. 2012
    ..These data establish Dnmt3a as a critical participant in the epigenetic silencing of HSC regulatory genes, thereby enabling efficient differentiation...
  20. pmc Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
    Nathalia Holt
    Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Nat Biotechnol 28:839-47. 2010
    ..The demonstration that a minority of CCR5(-/-) HSPCs can populate an infected animal with HIV-1-resistant, CCR5(-/-) progeny supports the use of ZFN-modified autologous hematopoietic stem cells as a clinical approach to treating HIV-1.
  21. ncbi Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment
    Benedetto Sacchetti
    Deparment of Experimental Medicine, La Sapienza University, 00161 Rome, Italy
    Cell 131:324-36. 2007
    ..Our data reveal the functional relationships between establishment of the HME in vivo, establishment of skeletal progenitors in BM sinusoids, and angiogenesis...
  22. pmc Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand
    Beate Heissig
    Division of Hematology Oncology, Cornell University Medical College, New York, NY 10021, USA
    Cell 109:625-37. 2002
    ..induced in BM cells, releases soluble Kit-ligand (sKitL), permitting the transfer of endothelial and hematopoietic stem cells (HSCs) from the quiescent to proliferative niche...
  23. pmc Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation
    Kairong Cui
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Cell Stem Cell 4:80-93. 2009
    ..changes in gene expression and histone modifications during differentiation of multipotent human primary hematopoietic stem cells/progenitor cells (HSCs/HPCs) into erythrocyte precursors...
  24. ncbi Foxo3a is essential for maintenance of the hematopoietic stem cell pool
    Kana Miyamoto
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Cell Stem Cell 1:101-12. 2007
    b>Hematopoietic stem cells (HSCs) are maintained in an undifferentiated quiescent state within a bone marrow niche...
  25. ncbi Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
    Fumio Arai
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo, 160 8582, Japan
    Cell 118:149-61. 2004
    The quiescent state is thought to be an indispensable property for the maintenance of hematopoietic stem cells (HSCs)...
  26. ncbi Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    Omer H Yilmaz
    Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Nature 441:475-82. 2006
    ..Mechanistic differences between normal stem cells and cancer stem cells can thus be targeted to deplete cancer stem cells without damaging normal stem cells...
  27. ncbi AC133, a novel marker for human hematopoietic stem and progenitor cells
    A H Yin
    AmCell Corp, Sunnyvale, CA 94089, USA
    Blood 90:5002-12. 1997
    ....
  28. ncbi Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Science 286:1735-8. 1999
    ..Thus, Bim is required for hematopoietic homeostasis and as a barrier to autoimmunity. Moreover, particular death stimuli appear to activate apoptosis through distinct BH3-only proteins...
  29. ncbi Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation
    Edward Owusu-Ansah
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California 90095, USA
    Nature 461:537-41. 2009
    ..Our results lead to a model that could be extended to reveal a probable signalling role for ROS in the differentiation of CMPs in mammalian haematopoietic development and oxidative stress response...
  30. ncbi Transgenic mice with hematopoietic and lymphoid specific expression of Cre
    Jasper de Boer
    Department of Molecular Immunology, National Institute for Medical Research, The Ridgeway, London, GB
    Eur J Immunol 33:314-25. 2003
    ..Both of these Cre-transgenic lines will be useful in generating tissue-specific gene deletions within all the cells of hematopoietic or lymphoid tissues...
  31. ncbi Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
    Keisuke Ito
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Nat Med 12:446-51. 2006
    b>Hematopoietic stem cells (HSCs) undergo self-renewing cell divisions and maintain blood production for their lifetime. Appropriate control of HSC self-renewal is crucial for the maintenance of hematopoietic homeostasis...
  32. ncbi Hematopoiesis: a human perspective
    Sergei Doulatov
    Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research Ontario Cancer Institute, Toronto, ON M5G 1L7, Canada
    Cell Stem Cell 10:120-36. 2012
    ....
  33. ncbi Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
    Leora B Balsam
    Departments of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 428:668-73. 2004
    ..1(lo) Lin- Sca-1+ long-term reconstituting haematopoietic stem cells adopt only traditional haematopoietic fates...
  34. ncbi Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches
    Tatsuki Sugiyama
    Department of Medical Systems Control, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Immunity 25:977-88. 2006
    In the bone marrow, the special microenvironment niches nurture a pool of hematopoietic stem cells (HSCs). Many HSCs reside near the vasculature, but the molecular regulatory mechanism of niches for HSC maintenance remains unclear...
  35. ncbi Purification and characterization of mouse hematopoietic stem cells
    G J Spangrude
    Department of Pathology, Stanford University School of Medicine, CA 94305
    Science 241:58-62. 1988
    Mouse bone marrow hematopoietic stem cells were isolated with the use of a variety of phenotypic markers. These cells can proliferate and differentiate with approximately unit efficiency into myelomonocytic cells, B cells, or T cells...
  36. pmc Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection
    Megan T Baldridge
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 465:793-7. 2010
    ..Our studies contribute to a deeper understanding of haematological responses in patients with chronic infections such as HIV/AIDS or tuberculosis...
  37. ncbi Hematopoietic stem cell quiescence maintained by p21cip1/waf1
    T Cheng
    Experimental Hematology, AIDS Research Center, Massachusetts General Hospital Cancer Center, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Science 287:1804-8. 2000
    Relative quiescence is a defining characteristic of hematopoietic stem cells, while their progeny have dramatic proliferative ability and inexorably move toward terminal differentiation...
  38. pmc Comprehensive methylome map of lineage commitment from haematopoietic progenitors
    Hong Ji
    Center for Epigenetics and Department of Medicine, Johns Hopkins University School of Medicine, 570 Rangos, 725 N Wolfe St, Baltimore, Maryland 21205, USA
    Nature 467:338-42. 2010
    ....
  39. ncbi Stem cells, cancer, and cancer stem cells
    T Reya
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Palo Alto, California 94305, USA
    Nature 414:105-11. 2001
    ....
  40. ncbi A role for Wnt signalling in self-renewal of haematopoietic stem cells
    Tannishtha Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 423:409-14. 2003
    ..We conclude that the Wnt signalling pathway is critical for normal HSC homeostasis in vitro and in vivo, and provide insight into a potential molecular hierarchy of regulation of HSC development...
  41. pmc Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
    Trista E North
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 447:1007-11. 2007
    ..The conserved role for PGE2 in the regulation of vertebrate HSC homeostasis indicates that modulation of the prostaglandin pathway may facilitate expansion of HSC number for therapeutic purposes...
  42. pmc Haematopoietic stem cells derive directly from aortic endothelium during development
    Julien Y Bertrand
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0380, USA
    Nature 464:108-11. 2010
    ..Finally, using a permanent lineage tracing strategy, we demonstrate that the HSCs generated from haemogenic endothelium are the lineal founders of the adult haematopoietic system...
  43. pmc Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
    Wendy W Pang
    Institute for Stem Cell Biology and Regenerative Medicine, Ludwig Center for Stem Cell Research, and Department of Pathology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 108:20012-7. 2011
    ....
  44. pmc Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells
    Liqi Li
    Section on Cellular and Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 12:129-36. 2011
    ..a critical and continuous requirement for Ldb1 in the maintenance of both fetal and adult mouse hematopoietic stem cells (HSCs)...
  45. ncbi Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration
    Shahin Rafii
    Department of Hematology Oncology and Genetic Medicine, Cornell University Medical College, New York, New York, 10021 USA
    Nat Med 9:702-12. 2003
    ..In this review, we discuss the clinical potential of vascular progenitor and stem cells to restore long-lasting organ vascularization and function...
  46. ncbi In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium
    Jean Charles Boisset
    Erasmus Medical Center, Department of Cell Biology, CA Rotterdam, The Netherlands
    Nature 464:116-20. 2010
    ..Here we show the dynamic de novo emergence of phenotypically defined HSCs (Sca1(+), c-kit(+), CD41(+)) directly from ventral aortic haemogenic endothelial cells...
  47. pmc Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder
    Ryan M O'Connell
    Department of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Exp Med 205:585-94. 2008
    ....
  48. pmc Imaging hematopoietic precursor division in real time
    Mingfu Wu
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cell Stem Cell 1:541-54. 2007
    ..These studies establish a system for tracking division of hematopoietic precursors and show that the balance of symmetric and asymmetric division can be influenced by the microenvironment and subverted by oncogenes...
  49. pmc Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
    Emmanuelle Passegue
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 202:1599-611. 2005
    Knowledge of the molecular networks controlling the proliferation and fate of hematopoietic stem cells (HSC) is essential to understand their function in maintaining blood cell production during normal hematopoiesis and upon clinical ..
  50. ncbi Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche
    Satoshi Yamazaki
    Japan Science and Technology Agency, ERATO, Chiyoda ku, Tokyo 102 0075, Japan
    Cell 147:1146-58. 2011
    b>Hematopoietic stem cells (HSCs) reside and self-renew in the bone marrow (BM) niche. Overall, the signaling that regulates stem cell dormancy in the HSC niche remains controversial...
  51. ncbi Long-term propagation of distinct hematopoietic differentiation programs in vivo
    Brad Dykstra
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada
    Cell Stem Cell 1:218-29. 2007
    Heterogeneity in the differentiation behavior of hematopoietic stem cells is well documented but poorly understood...
  52. pmc Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration
    Wolfram Goessling
    Harvard Stem Cell Institute, Cambridge, MA 02138, USA
    Cell 136:1136-47. 2009
    ..Prostaglandin (PG) E2 regulates vertebrate hematopoietic stem cells (HSC). Similarly, the Wnt signaling pathway controls HSC self-renewal and bone marrow repopulation...
  53. pmc TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
    Chong Chen
    Program of Cell and Developmental Biology, Division of Immunotherapy, Department of Surgery, University of Michigan Medical School and Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    J Exp Med 205:2397-408. 2008
    ..We used conditional deletion of Tsc1 to address how quiescence is associated with the function of hematopoietic stem cells (HSCs)...
  54. pmc A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia
    Apostolos Klinakis
    Biomedical Research Foundation, Academy of Athens, Athens, Greece
    Nature 473:230-3. 2011
    ..Our studies identify a novel role for Notch signalling during early haematopoietic stem cell differentiation and suggest that the Notch pathway can play both tumour-promoting and -suppressive roles within the same tissue...
  55. pmc Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation
    Jonathan Hoggatt
    Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine IUSM, Indianapolis, IN 46202, USA
    Blood 113:5444-55. 2009
    Adult hematopoietic stem cells (HSCs) are routinely used to reconstitute hematopoiesis after myeloablation; however, transplantation efficacy and multilineage reconstitution can be limited by inadequate HSC number, or poor homing, ..
  56. ncbi Identification of clonogenic common lymphoid progenitors in mouse bone marrow
    M Kondo
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Cell 91:661-72. 1997
    ..A single Lin(-)IL-7R(+)Thy-1(-)Sca-1loc-Kit(lo) cell could generate at least both T and B cells. These data provide direct evidence for the existence of common lymphoid progenitors in sites of early hematopoiesis...
  57. ncbi Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants
    David Traver
    Children s Hospital Boston and the Howard Hughes Medical Institute, 320 Longwood Avenue, Enders 720, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1238-46. 2003
    ..Direct visualization of fluorescent donor cells in embryonic recipients allows engraftment and homing events to be imaged in real time. These results provide a cellular context in which to study the genetics of hematopoiesis...
  58. pmc Cell cycle regulation in hematopoietic stem cells
    Eric M Pietras
    Department of Medicine, Division of Hematology Oncology, The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 195:709-20. 2011
    b>Hematopoietic stem cells (HSCs) give rise to all lineages of blood cells...
  59. ncbi How do stem cells find their way home?
    Tsvee Lapidot
    Weizmann Institute of Science, Department of Immunology, PO Box 26, Rehovot, 76100, Israel
    Blood 106:1901-10. 2005
    Migration of hematopoietic stem cells through the blood, across the endothelial vasculature to different organs and to their bone marrow (BM) niches, requires active navigation, a process termed homing...
  60. ncbi OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    Y Y Kong
    Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Nature 397:315-23. 1999
    ..Thus OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo...
  61. pmc Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice
    Lara Rossi
    Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Stem Cell 11:302-17. 2012
    b>Hematopoietic stem cells (HSCs) represent one of the first recognized somatic stem cell types. As such, nearly 200 genes have been examined for roles in HSC function in knockout mice...
  62. pmc Epigenetic memory in induced pluripotent stem cells
    K Kim
    Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 467:285-90. 2010
    ....
  63. pmc Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells
    Anthony E Boitano
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 329:1345-8. 2010
    ..Mechanistic studies show that SR1 acts by antagonizing the aryl hydrocarbon receptor (AHR). The identification of SR1 and AHR modulation as a means to induce ex vivo HSC expansion should facilitate the clinical use of HSC therapy...
  64. pmc Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation
    Cheng Cheng Zhang
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Blood 111:3415-23. 2008
    b>Hematopoietic stem cells (HSCs) are the basis of bone marrow transplantation and are attractive target cells for hematopoietic gene therapy, but these important clinical applications have been severely hampered by difficulties in ex vivo ..
  65. pmc Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis
    Mary Mohrin
    The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Medicine, Division of Hematology Oncology, University of California San Francisco, San Francisco, CA 94143, USA
    Cell Stem Cell 7:174-85. 2010
    Most adult stem cells, including hematopoietic stem cells (HSCs), are maintained in a quiescent or resting state in vivo...
  66. ncbi Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs
    Ingrid G Winkler
    Haematopoietic Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, Australia
    Blood 116:4815-28. 2010
    In the bone marrow, hematopoietic stem cells (HSCs) reside in specific niches near osteoblast-lineage cells at the endosteum...
  67. pmc PML targeting eradicates quiescent leukaemia-initiating cells
    Keisuke Ito
    Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Harvard Medical School, New Research Building, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nature 453:1072-8. 2008
    ....
  68. pmc Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells
    John P Chute
    Division of Cellular Therapy, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:11707-12. 2006
    ..ALDH is also highly enriched in hematopoietic stem cells (HSCs) and is considered a selectable marker of human HSCs, although its contribution to stem cell fate ..
  69. ncbi Blood stem cells emerge from aortic endothelium by a novel type of cell transition
    Karima Kissa
    Institut Pasteur, Unité Macrophages et Développement de l Immunité and CNRS URA2578, 25 rue du Dr Roux, F 75724 Paris Cedex 15, France
    Nature 464:112-5. 2010
    ....
  70. ncbi Bone marrow as a potential source of hepatic oval cells
    B E Petersen
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Science 284:1168-70. 1999
    ..From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability...
  71. ncbi Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
    D Lyden
    Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
    Nat Med 7:1194-201. 2001
    ..These data demonstrate that recruitment of VEGF-responsive BM-derived precursors is necessary and sufficient for tumor angiogenesis and suggest new clinical strategies to block tumor growth...
  72. pmc Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1
    Grant A Challen
    Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Stem Cell 6:265-78. 2010
    ..has been that all the cells of the peripheral blood are the progeny of a unitary homogeneous pool of hematopoietic stem cells (HSCs)...
  73. ncbi Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
    E W Scott
    Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, University of Chicago, IL 60637
    Science 265:1573-7. 1994
    ..Thus, the developmental programs of lymphoid and myeloid lineages require a common genetic function likely acting at the level of a multipotential progenitor...
  74. ncbi CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow
    Abraham Avigdor
    Immunology Department, The Weizmann Institute of Science, Rehovot, Israel
    Blood 103:2981-9. 2004
    ..Taken together, our data suggest a key role for CD44 and HA in SDF-1-dependent transendothelial migration of HSCs/HPCs and their final anchorage within specific niches of the BM...
  75. pmc VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    Rosandra N Kaplan
    Department of Pediatrics and the Children s Blood Foundation Laboratories, Weill Cornell Medical College of Cornell University, New York, New York 10021, USA
    Nature 438:820-7. 2005
    ..These findings demonstrate a requirement for VEGFR1+ haematopoietic progenitors in the regulation of metastasis, and suggest that expression patterns of fibronectin and VEGFR1+VLA-4+ clusters dictate organ-specific tumour spread...
  76. ncbi Dystrophin expression in the mdx mouse restored by stem cell transplantation
    E Gussoni
    Division of Genetics, Children s Hospital, Boston, Massachusetts 02115, USA
    Nature 401:390-4. 1999
    ..Our studies also suggest that the inherent developmental potential of stem cells isolated from diverse tissues or organs may be more similar than previously anticipated...
  77. ncbi The Ikaros gene is required for the development of all lymphoid lineages
    K Georgopoulos
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown 02129
    Cell 79:143-56. 1994
    ..In the absence of a functional Ikaros gene, these stem cells are exclusively diverted into the erythroid and myeloid lineages...
  78. pmc p53 regulates hematopoietic stem cell quiescence
    Yan Liu
    Molecular Phamacology and Chemistry Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cell Stem Cell 4:37-48. 2009
    ..Establishing the role of p53 (and its target genes) in controlling the cell-cycle entry of HSCs may lead to therapeutic strategies capable of eliminating quiescent cancer (stem) cells...
  79. ncbi Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
    Susan M Graham
    Department of Medicine, Royal Infirmary, Glasgow, Scotland
    Blood 99:319-25. 2002
    ..Despite dramatic short-term responses in vivo, such in vitro insensitivity to STI571, in combination with its demonstrated antiproliferative activity, could translate into disease relapse after prolonged therapy...
  80. pmc MicroRNA miR-125a controls hematopoietic stem cell number
    Shangqin Guo
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:14229-34. 2010
    ..microRNA cluster containing miR-99b, let-7e, and miR-125a was preferentially expressed in long-term hematopoietic stem cells. MicroRNA miR-125a alone was capable of increasing the number of hematopoietic stem cells in vivo by more ..
  81. ncbi Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
    Keisuke Ito
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Nature 431:997-1002. 2004
    ..These results show that the self-renewal capacity of HSCs depends on ATM-mediated inhibition of oxidative stress...
  82. pmc Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells
    Jason M Butler
    Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Cell Stem Cell 6:251-64. 2010
    ..ECs) are essential for reconstitution of hematopoiesis, but their role in self-renewal of long-term hematopoietic stem cells (LT-HSCs) is unknown...
  83. ncbi Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment
    Faiyaz Notta
    Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research Ontario Cancer Institute, Toronto, Ontario, Canada
    Science 333:218-21. 2011
    Lifelong blood cell production is dependent on rare hematopoietic stem cells (HSCs) to perpetually replenish mature cells via a series of lineage-restricted intermediates...
  84. ncbi Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells
    Raoul Tibes
    Department of Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    Mol Cancer Ther 5:2512-21. 2006
    ....
  85. pmc CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis
    Siddhartha Jaiswal
    Ludwig Center at Stanford, Stanford Cancer Center, Department of Pathology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 138:271-85. 2009
    ..find that mobilizing cytokines and inflammatory stimuli cause CD47 to be transiently upregulated on mouse hematopoietic stem cells (HSCs) and progenitors just prior to and during their migratory phase, and that the level of CD47 on ..
  86. ncbi Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients
    Hillard M Lazarus
    Department of Medicine, The University Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA
    Biol Blood Marrow Transplant 11:389-98. 2005
    ..We hypothesized that cotransplantation of culture-expanded MSCs and hematopoietic stem cells (HSCs) from HLA-identical sibling donors after myeloablative therapy could facilitate engraftment and ..
  87. ncbi Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
    Catriona H M Jamieson
    Division of Hematology, Stanford University School of Medicine, Stanford, Calif 94305 5323, USA
    N Engl J Med 351:657-67. 2004
    ..In normal mouse hematopoietic stem cells, the process of self-renewal involves the beta-catenin-signaling pathway...
  88. pmc Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter
    Michael J Chen
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Nature 457:887-91. 2009
    ..Collectively these data show that Runx1 function is essential in endothelial cells for haematopoietic progenitor and HSC formation from the vasculature, but its requirement ends once or before Vav is expressed...
  89. pmc Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells
    K A Jackson
    Center for Cell and Gene Therapy and Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    J Clin Invest 107:1395-402. 2001
    ..a source of stem cells capable of restoring damaged cardiac tissue, we transplanted highly enriched hematopoietic stem cells, the so-called side population (SP) cells, into lethally irradiated mice subsequently rendered ischemic ..
  90. ncbi Mesenchymal stem cells: biology and potential clinical uses
    R J Deans
    Osiris Therapeutics, Baltimore, MD 21231, USA
    Exp Hematol 28:875-84. 2000
    ..Preclinical and early clinical safety studies are paving the way for further applications of mesenchymal stem cells in the field of transplantation with respect to hematopoietic support, immunoregulation, and graft facilitation...
  91. pmc Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells
    Agamemnon E Grigoriadis
    Department of Craniofacial Development and Orthodontics, Guy s Hospital, King s College London, London, UK
    Blood 115:2769-76. 2010
    ..Generating hematopoietic and osteoclast populations from human embryonic and induced pluripotent stem cells will be invaluable for understanding embryonic bone development and postnatal bone disease...
  92. ncbi Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
    Hannah H Chang
    Vascular Biology Programme, Department of Pathology and Surgery, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 453:544-7. 2008
    ....
  93. ncbi Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential
    Maxim A Vodyanik
    Department of Pathology and Laboratory Medicine, Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53792 8550, USA
    Blood 105:617-26. 2005
    ..These data indicate that CD34+ cells generated through hES/OP9 coculture display several features of definitive hematopoietic stem cells.
  94. pmc Fate tracing reveals the endothelial origin of hematopoietic stem cells
    Ann C Zovein
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Cell Stem Cell 3:625-36. 2008
    b>Hematopoietic stem cells (HSCs) originate within the aortic-gonado-mesonephros (AGM) region of the midgestation embryo, but the cell type responsible for their emergence is unknown since critical hematopoietic factors are expressed in ..
  95. ncbi Regulation of the HIF-1alpha level is essential for hematopoietic stem cells
    Keiyo Takubo
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Cell Stem Cell 7:391-402. 2010
    b>Hematopoietic stem cells (HSCs) are sustained in a specific microenvironment known as the stem cell niche. Mammalian HSCs are kept quiescent in the endosteal niche, a hypoxic zone of the bone marrow (BM)...
  96. ncbi Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development
    Sergei Doulatov
    Department of Stem Cell and Developmental Biology, Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    Nat Immunol 11:585-93. 2010
    ..Thus, as in the mouse, human hematopoiesis does not follow a rigid model of myeloid-lymphoid segregation...
  97. pmc A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
    Yoon Young Jang
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Blood 110:3056-63. 2007
    ..in bone marrow limits reactive oxygen species (ROS) production, thus providing long-term protection for hematopoietic stem cells (HSCs) from ROS stress...
  98. pmc Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
    Kalindi Parmar
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:5431-6. 2007
    ....
  99. pmc Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders
    Zhaohui Ye
    Stem Cell Program, Institute for Cell Engineering, and Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Blood 114:5473-80. 2009
    ..These iPS cells provide a renewable cell source and a prospective hematopoiesis model for investigating MPD pathogenesis...
  100. pmc Aging and replicative senescence have related effects on human stem and progenitor cells
    Wolfgang Wagner
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 4:e5846. 2009
    ..Changes upon aging of MSC and HPC are related to those of replicative senescence of MSC in vitro and this indicates that our stem and progenitor cells undergo a similar process also in vivo...
  101. ncbi Haematopoietic stem cell release is regulated by circadian oscillations
    Simon Mendez-Ferrer
    Mount Sinai School of Medicine, Department of Medicine and Department of Gene and Cell Medicine, New York, New York 10029, USA
    Nature 452:442-7. 2008
    ..These data indicate that a circadian, neurally driven release of HSC during the animal's resting period may promote the regeneration of the stem cell niche and possibly other tissues...

Research Grants122 found, 100 shown here

  1. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..and developmental processes including angiogenesis, lymphocyte trafficking and the migration of hematopoietic stem cells, natural killer cells, and cancer cells...
  2. Transgenesis and Xenotransplantation
    Jorge A Piedrahita; Fiscal Year: 2013
    ..Aim2. To develop a pig hosting a human immune system. Aim 2a. We will utilize human/or swine bone marrow hematopoietic stem cells (HSC) to repopulate the immune system by injecting into a developing fetus prior to immune maturation...
  3. Targeting CC-Chemokine Receptor 7 for the prevention of graft-versus-host disease
    JAMES M COGHILL; Fiscal Year: 2013
    ..involves the administration of chemotherapy and/or radiation to patients, followed by the transplant of hematopoietic stem cells from a sibling or unrelated matched donor...
  4. Integrated signaling of eicosanoids in HSC formation and regeneration
    Trista E North; Fiscal Year: 2013
    ..In vertebrates, definitive hematopoietic stem cells (HSCs) produce each of the mature blood cell lineages of an individual throughout its lifetime...
  5. Pluripotent stem cell-derived HSCs: improvements and molecular mechanisms
    Patrick Cahan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hematopoietic stem cells (HSC), largely residing in the bone marrow of adult mammals, are the progenitors of all blood cells, including all myeloid and lymphoid lineages...
  6. Hematopoietic Stem Cells (HSCs) as Juvenile Protective Factors that Alter Aging
    David E Harrison; Fiscal Year: 2011
    ....
  7. The Role of Interferon-gamma in the Regulation of Hematopoietic Stem Cells
    KATHERINE YUDEH KING; Fiscal Year: 2013
    ..Cells of the host immune response are ultimately derived from hematopoietic stem cells (HSCs) in bone marrow...
  8. Hematopoietic Stem Cell Transplantation in Osteogenesis Imperfecta
    Meenal Mehrotra; Fiscal Year: 2012
    ..decided to combine my background in bone biology with my current studies of stem cells to investigate the hematopoietic stem cells (HSCs) as a potential therapy for bone disorders...
  9. B Cell Development in Aging
    John C Cambier; Fiscal Year: 2010
    ..are reduced in numbers, and this is correlated with reduction in the FO B cell generative capacity of hematopoietic stem cells (HSCs)...
  10. Development of a Pediatric Mylelodysplastic Syndrome Patient Registry
    DAVID A contact WILLIAMS; Fiscal Year: 2010
    ..This project will be lead by Drs. David A. Williams (known for his expertise in hematopoietic stem cells and bone marrow failure disorders) and Mark D...
  11. SATB1-dependent epigenetic regulation of leukemia initiating cells
    Britta Will; Fiscal Year: 2011
    ..In the hematopoietic system, the interplay of particular transcription factors instructs normal hematopoietic stem cells (HSC) to function in a precise manner...
  12. Neonatal Chemoselection Following Ex Vivo Gene Transfer For Hereditary Disorders
    KARIN L GAENSLER; Fiscal Year: 2012
    ..variety of inherited disorders, is limited by a shortage of compatible donors, low numbers of engrafting hematopoietic stem cells (HSC), the toxicity of necessary preparative regimens and post-transplant immunosuppression, and graft vs...
  13. Erythropoietin in Non-Erythroid Cells: Function and Regulation
    Josef T Prchal; Fiscal Year: 2013
    ..been reported and transcripts of EPO and/or its receptor (EPOR) genes are found in brain, endothelium, hematopoietic stem cells, breast, ovary, testes, and other tissues...
  14. Non-viral gene therapy for sickle cell anemia
    CLIFFORD JOHN STEER; Fiscal Year: 2012
    ..optimize the Sleeping Beauty transposon (SB-Tn) and transfection efficiency in mouse bone marrow (BM) and hematopoietic stem cells (HSCs)...
  15. DNA Methylation Control Hematopoietic Stem Cell Lineage Differentiation
    GRANT ANTHONY CHALLEN; Fiscal Year: 2013
    ..My work in understanding the molecular regulation of hematopoietic stem cells is motivated by a desire to improve the lives of patients afflicted with hematopoietic disorders and my ..
  16. Molecular Studies of Bone Marrow Failure
    Monica Bessler; Fiscal Year: 2013
    ..We hypothesize that premature senescence of hematopoietic stem cells is the basis of BMF in patients with DC and that the major cause of premature senescence is dysfunctional ..
  17. Over-Expression of microRNA-126 in Macrophages for Treatment of Atherosclerosis
    Suzette Laing; Fiscal Year: 2013
    ..Since macrophages derived from bone marrow hematopoietic stem cells (HSC), are key to the initiation and progression of atherosclerosis, the therapeutic potential of over-..
  18. Novel therapies for Fanconi anemia
    DAVID A contact WILLIAMS; Fiscal Year: 2010
    ..even early in the disease process there are significant deficiencies in the number and/or function of hematopoietic stem cells (HSCs) that can be collected and utilized as targets in gene transfer...
  19. Stem cell mutagenesis mediated by age and niche
    VIVIENNE ILONA REBEL; Fiscal Year: 2011
    ..We will test this premise by measuring mutant frequency in hematopoietic stem cells and compare this to that measured in differentiated cells of the myeloid - and B-cell lineage...
  20. Endothelial Progenitor Cells and Particulate Air Pollution
    Arden Pope; Fiscal Year: 2013
    ..of EPC are affected and whether this response is selective to EPCs or other stem cells such as the hematopoietic stem cells and mesenchymal stem cells are affected as well...
  21. NFAT Signaling and Down Syndrome
    Gerald R Crabtree; Fiscal Year: 2012
    ..Initially we will determine if samples from DS human fetuses, cord blood hematopoietic stem cells and T lymphocytes have the expected biochemical and genetic features of reduced NFAT activity and reduced ..
  22. Studying a Human Stem Cell Disease Using iPS Technology
    Steven E Artandi; Fiscal Year: 2010
    ..of DC iPS cells through embryoid body formation, teratoma development and directed differentiation to hematopoietic stem cells (HSCs)...
  23. Functional analysis of mDia formins in hematopoietic stem cell engraftment and mi
    Peng Ji; Fiscal Year: 2010
    ..However, their effects on the migration of hematopoietic cells, especially hematopoietic stem cells (HSCs), are poorly understood...
  24. Lentiviral-transduced hematopoictic stem cell transplantation for cystinosis
    Stephanie Cherqui; Fiscal Year: 2013
    ..objective of this project is to develop a new treatment for cystinosis by transplantation of autologous hematopoietic stem cells genetically modified ex vivo to express a functional CTNS gene...
  25. Genome instability in leukemia stem cell
    Tomasz Skorski; Fiscal Year: 2010
    ..results from t(9;22) reciprocal chromosomal translocation and is leukemogenic only when expressed in a hematopoietic stem cells (HSCs) with self-renewal capacity thereby inducing leukemia stem cell (LSC)...
  26. Reactivation of Fetal Gamma-globin Genes for the Treatment of Beta-globin Disorde
    Osamu Tanabe; Fiscal Year: 2010
    ..develop novel, tailored agents than can induce the generation of human fetal red blood cells from adult hematopoietic stem cells by reprogramming beta-type globin gene regulation...
  27. Identification of novel target genes for polycythemia vera (PV)
    Shaoguang Li; Fiscal Year: 2013
    ..chronic myeloid leukemia (CML), these Philadelphia chromosome-negative (Ph-) MPNs are also derived from hematopoietic stem cells (HSCs) and have a risk of developing thrombosis and acute leukemia...
  28. Adipose Stem Cell Therapy for Krabbe Disease
    Bruce Bunnell; Fiscal Year: 2009
    ..Our Preliminary data indicates that GALC is expressed not only by hematopoietic stem cells but also by adipose derived stem cells...
  29. There Will Be Blood: Stem Cell Niche Driven Derivation of HSC from ES Cells
    PAUL JOHN SIMMONS; Fiscal Year: 2010
    ..There Will be Blood: Stem cell niche driven derivation of HSC from ES cells Transplantation of hematopoietic stem cells (HSCs) derived from high-quality sources of tissue-matched bone marrow, mobilized peripheral blood or ..
  30. Inflammation and Cerebral Aneurysm Formation: Targets for Modulation and Vascular
    BRIAN LIM HOH; Fiscal Year: 2013
    ..Under the third aim, cell-specific populations of CD133+ endothelial progenitor cells (EPCs), hematopoietic stem cells, and mesenchymal stem cells will be seeded into Matrigel and other polymers developed by our collaborator,..
  31. The Role of Fibrocytes in Liver Fibrosis
    Tatiana Kisseleva; Fiscal Year: 2012
    ..We predict that fibrocytes originate from c-kit+Sca-1+ hematopoietic stem cells, but developmentally precede CMP during hematopoiesis...
  32. Novel Erythroid Cell Membrane Protein
    Emery H Bresnick; Fiscal Year: 2010
    ..GATA-2 regulates the proliferation/survival of hematopoietic stem cells (HSCs), whereas GATA-1 promotes the differentiation of erythroid, megakaryocyte, eosinophil, and mast ..
  33. Tomotherapy and Hematopoietic Stem Cells For Tolerance to Kidney Transplants
    Samuel Strober; Fiscal Year: 2013
    ..helical tomotherapy-based TLI and rabbit anti-thymocyte globulin (ATG) and given purified donor CD34+ hematopoietic stem cells (HSC) and specified doses of donor T cells...
  34. Murine Model of HCV-Associated Human Liver Cancer
    Lishan Su; Fiscal Year: 2013
    ..AFC8- hu mice engrafted with CD34+ human hematopoietic stem cells and EpCAM+ human hepatoblasts and hepatic stem cells achieve ~18% hepatic chimerism, are permissive for ..
  35. Role of the zinc finger transcription factor ZBP89 in blood &vascular developmen
    M Amin Arnaout; Fiscal Year: 2013
    The hematopoietic system originates from a small population of self-renewing hematopoietic stem cells (HSCs) that in turn derive from hemangioblasts, common precursors of blood and blood vessels...
  36. DNA-PKcs Phosphorylation on Hematopoietic Stem Cells Genome Maintenance
    Benjamin Ping Chi Chen; Fiscal Year: 2013
    ..Loss of hematopoietic stem cells (HSCs) in DNA-PKcs3A/3A mice is caused by elevated genotoxic stress as evidenced by increased intestinal ..
  37. System for Rapid Generation of Aptamers for Transplant Therapies
    KAREN QIAN; Fiscal Year: 2010
    ..During the treatment, anti CD34 antibodies are used to enrich the CD34+ hematopoietic stem cells from mobilized peripheral blood, which are re-infused after a high-dose radio/chemotherapy...
  38. Functional Genomic Dissection of Refractory Anemia
    BENJAMIN LEVINE EBERT; Fiscal Year: 2013
    ..and combined haploinsufficiency for RPS14 and miR-145, and to examine the effects of these lesions on hematopoietic stem cells. In addition, having established an approach to the identification of key MDS genes within chromosomal ..
  39. Development of Human, Autologous, Pluripotent Very Small Embryonic Like (VSELs) s
    DENIS OVEREND RODGERSON; Fiscal Year: 2013
    ..Most importantly, VSELs are resistant to lethal irradiation, which destroys hematopoietic stem cells and most other stem cells in the body...
  40. Mechanisms linking RAS signals to disordered hematopoiesis and myeloid neoplasia
    BENJAMIN BRAUN; Fiscal Year: 2013
    ..MegE lineage commitment in immature populations such as hematopoietic stem cells. This will be addressed using time lapse cell culture methods to observe cell fate in real time, and ..
  41. Gene Therapy of Mucopolysaccharidosis VII
    Mark E Haskins; Fiscal Year: 2012
    ..An alternative approach is to perform ex vivo transduction of hematopoietic stem cells (HSC) with a lentiviral vector (LV). The laboratory of Dr...
  42. Homing Receptor Determinants of HSC
    Irving L Weissman; Fiscal Year: 2013
    ..by applicant): Successful hematopoietic transplantation relies on the capacity of intravenously infused hematopoietic stem cells (HSC) to home to and engraft bone marrow...
  43. Platelet-Derived FVIII Gene Therapy of Hemophilia A
    Qizhen Shi; Fiscal Year: 2013
    ..Our most recent studies have demonstrated that syngeneic transplantation of hematopoietic stem cells (HSC) from 2bF8 transgenic mice can efficiently restore hemostasis to hemophilic mice with inhibitors...
  44. AID-mediated genetic instability in BCR-ABL1-transformed B cell lineage leukemia
    MARKUS MUSCHEN; Fiscal Year: 2013
    ..1) Transformation of hematopoietic stem cells (HSC) by p210 BCR-ABL1 induces CML-like leukemia with subsequent progression into B lymphoid blast crisis...
  45. Chronic Toll-like Receptor Ligation and Hematopoietic Stem Cell Aging
    Brandt L Esplin; Fiscal Year: 2010
    ..the most characterized of any stem-cell driven tissue;and given the astronomical output requirements of hematopoietic stem cells (HSC) over a lifespan, this system has become an optimal target for studies on aging and regenerative ..
  46. Beta-Globin Gene Correction Using Peptide Nucleic Acids for the Treatment of Sick
    GERALD FRANCIS VOVIS; Fiscal Year: 2010
    ..Helix Therapeutics is proposing to develop a therapeutic gene targeting agent to correct, in human hematopoietic stem cells, the mutation responsible for causing SCD and, thus, cure the disease permanently.
  47. The p110 alpha and delta isoforms of PI3 kinase in hematopoiesis and leukemia
    Kira Gritsman; Fiscal Year: 2013
    ..This is largely attributed to the toxic effects that most antileukemic drugs have on hematopoietic stem cells (HSC), frequently leading to cytopenias...
  48. Stem cells and the fibroblast/adipocyte lineage in arrhythmogenic cardiomyopathy
    Karen L Vikstrom; Fiscal Year: 2010
    ..of generating a cardiac fibroblast lineage: the epithelial cells that comprise the epicardium, and the hematopoietic stem cells. Through the use of novel mouse molecular genetic strategies, and cell biological assays, we will test ..
  49. Defining Estrogenic Regulation of Hematopoietic Stem Cell Formation and Function
    Trista E North; Fiscal Year: 2013
    ..Definitive hematopoietic stem cells (HSCs) both self-renew and differentiate to produce each of the mature blood cell lineages for the entire ..
  50. Slit2-mediated expansion of primitive hematopoietic stem cell populations for tra
    Gary Van Zant; Fiscal Year: 2010
    ..expansion of primitive hematopoietic stem cell populations for transplantation and hematopoietic recovery Hematopoietic Stem Cells (HSCs) integrate signals from the niche with cell intrinsic regulatory programs to maintain the ..
  51. The Molecular Mechanisms by which the Paf Oncogene Mediates Hematopoiesis
    Lisa K Denzin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Differentiation of hematopoietic stem cells (HSCs) is required for the production and maintenance of all blood cell types for the life of an organism...
  52. Novel Strategies for Treatment of Myeloproliferative Disorders
    Roya Khosravi-Far; Fiscal Year: 2012
    ..proteasomal degradation of FOXO3a will inhibit tumor-suppressor activity of FOXO3a in Bcr-Abl-expressing hematopoietic cells, potentially hematopoietic stem cells, and this leads to subsequent survival and leukemogenesis.
  53. ANALYSIS OF A NOVEL SUBSET OF HUMAN CD8+ MEMORY CELLS WITH STEM CELL QUALITIES
    Stanley R Riddell; Fiscal Year: 2010
    ..enable their separation from the more prevalent TCM and TEM subsets, and includes molecules shared by hematopoietic stem cells. These quiescent memory T cells exhibit higher ATP binding cassette (ABC) transporter activity, rapidly ..
  54. Cancer epigenetics: Understanding histone methylation in leukemia stem cells
    Gang Greg Wang; Fiscal Year: 2011
    ..Our preliminary data also suggests that such a novel epigenetic mechanism transforms normal hematopoietic stem cells (HSCs) to leukemia-initiating stem cells (LSCs)...
  55. Novel mechanisms of immune activation following allogeneic, hematopoietic stem ce
    JOHN JAMES LETTERIO; Fiscal Year: 2013
    ..implicate a role for Cdk5 in lymphocyte activation by 1) developing a new chimeric mouse model in which hematopoietic stem cells from Cdk5 deficient (Cdk5-/-) embryos are used to reconstitute lethally irradiated adult mouse recipients ..
  56. Phase 1 Study of Umbilical Cord Blood-Derived T Cells in Malignant B Cells
    Elizabeth J Shpall; Fiscal Year: 2013
    ..The introduction of umbilical cord blood (UCB) as an alternative source of allogeneic hematopoietic stem cells (HSC) for patients without a suitable human leukocyte antigen (HLA)-matched donor is a major advance for ..
  57. miRNAs and epidermal langerhans cell development and function
    Qing Sheng Mi; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Dendritic cells (DCs), a heterogeneous population originating from hematopoietic stem cells (HSCs) in the bone marrow (BM), are professional antigen-presenting cells that play key roles in determining ..
  58. Myxoma Virus (MV) Oncolysis for treating human cancer
    Grant McFadden; Fiscal Year: 2013
    ..Specifically, our aims are: 1) Validate MV safety for ex vivo treatment of normal human hematopoietic stem cells: The safety of MV-purging for normal human stem cell differentiation will be tested, using engrafted ..
  59. Analysis of mDia formins in hematopoietic stem cell engraftment and migration
    Peng Ji; Fiscal Year: 2013
    ..However, their effects on the migration of hematopoietic cells, especially hematopoietic stem cells (HSCs), are poorly understood...
  60. Hematopoietic gene therapy for hemophilia A
    H Trent Spencer; Fiscal Year: 2013
    ..extremely efficiently in a mouse model of hemophilia A following transplantation of genetically-modified hematopoietic stem cells (HSCs)...
  61. Role of Vav and Rac in KIT oncogenesis
    Reuben Kapur; Fiscal Year: 2013
    ..with important functional roles in melanocytes, germ cells, interstitial cells of Cajal, mast cells, and hematopoietic stem cells. Consistent with the importance of KIT in these defined tissues, activating mutations of KIT have been ..
  62. Critical roles of GA binding protein in HSC maintenance and ageing
    Hai Hui Xue; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hematopoietic stem cells (HSCs) have two defining features...
  63. Beta-catenin is a molecular target of the Fanconi anemia core complex
    Kim Hien T Dao; Fiscal Year: 2013
    ..in genes of the FA pathway, classically described as a DNA damage response pathway, give rise to hematopoietic stem cells with inherent defects in stem cell fitness...
  64. Interferon Effects on HIV Transmission in Human Models
    Judy Lieberman; Fiscal Year: 2013
    ..in 2 "human" models - polarized human cervical explants and humanized mice transplanted with fetal human hematopoietic stem cells, liver and thymus ("BLT mice")...
  65. Wnt Signaling in Hematopoietic Stem Cell Specification and Leukemia
    WILSON KENDRICK CLEMENTS; Fiscal Year: 2013
    Project Summary/Abstract Hematopoietic stem cells (HSCs) are progenitor cells that have the ability to both self-renew and regenerate all mature blood cell types, including red blood cells and immune cells over the lifetime of an ..
  66. Structural microenvironment of bone marrow stem cells
    FRANCESCO B RAMIREZ; Fiscal Year: 2013
    ..component of the BM microenvironment that specifies the performance of mesenchymal stem cells (MSC) and hematopoietic stem cells (HSC)...
  67. A megakaryocyte/PGE2/osteoblast triad in the normal and aged niche
    Louis M Pelus; Fiscal Year: 2013
    ..Defects in the function of hematopoietic stem cells (HSC) with age, particularly myeloid skewing with increased incidence of myeloid malignancies and ..
  68. Novel molecular imaging approaches to monitor gene and cell-based therapies
    Shahriar Yaghoubi; Fiscal Year: 2013
    ..applicable to therapies for diseases with significant public health impact, including transplantation of hematopoietic stem cells in congenital and acquired disorders such as AIDS, islet cells in type 1 diabetes, ES-derived neural stem ..
  69. Targeting the DNA Damage Response for the Treatment of Herpes Simplex Labialis
    WILLIAM DONEGAN; Fiscal Year: 2013
    ..5%-7% of HIV-positive patients and at a rate of 4.1%-10.9% in recipients of hematopoietic stem cells. Since most of the drugs used to treat infection are derived from acyclovir and have the same mechanism ..
  70. Enhancement of Fracture Repair by Hematopoietic Stem Cells
    Amanda C LaRue; Fiscal Year: 2013
    ..Findings from the proposed studies have the potential to impact Veterans Health Care by identifying unique stem cell-based therapies for improving recovery from fracture. ..
  71. Myeloid Lineage Differentiation and Osteoclast Priming by a Novel Pax5 Cytokine
    Mark C Horowitz; Fiscal Year: 2013
    ..like macrophages, granulocytes and dendritic cells, are members of the myeloid lineage arising from hematopoietic stem cells. During the early stages of hematopoietic cell differentiation multipotential progenitor (MPP) cells can ..
  72. Sorafenib for Hepatopulmonary Syndrome
    Steven M Kawut; Fiscal Year: 2013
    ..We will determine the safety and potential efficacy of sorafenib as a novel therapeutic for the treatment of HPS. ..
  73. Lymphoid Tissue Inducer/NK22 Cells and Post-transplant Immune Recovery
    Michael R Verneris; Fiscal Year: 2013
    ..To overcome these issues, we are the only laboratory to have generated LTi cells from human hematopoietic stem cells (HSCs). HSC-derived LTi cells are identical to those isolated from LNs...
  74. Cyclin A Function in Stem Cells and in Neoplasia
    Peter Sicinski; Fiscal Year: 2013
    ..In contrast, we observed that A-cyclins play an essential function in hematopoietic stem cells and in embryonic stem (ES) cells...
  75. Yes1 as a quiescence regulator in hematopoietic stem cells
    Siddhartha Mukherjee; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hematopoietic stem cells (HSCs) in the bone marrow are maintained in a quiescent state (i.e...
  76. Functional relevance of cardiac regeneration by c-kit positive stem cells
    JOHANNES VAN BERLO; Fiscal Year: 2013
    ..relevant sources of renewal include bone marrow derived cells, such as mesenchymal stem cells, hematopoietic stem cells or endothelial progenitor cells, stem cells residing in the heart, so called Cardiac Progenitor Cells (..
  77. Lig4R278H contribution to HSC and IgH class switching defects and malignancies
    Catherine T Yan; Fiscal Year: 2013
    ..Blood cells of all lineages are generated from small pools of long-lived hematopoietic stem cells (HSCs) that have the ability to continually replenish, self-renew, and generate differentiated progeny...
  78. Rac proteins in hematopoietic cell survival and function
    David A Williams; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The use of hematopoietic stem cells (HSC) in transplant biology and the potential use of these cells, which in the future may be derived by reprogramming methods, in regenerative medicine can be ..
  79. Cincinnati Center for Excellence in Molecular Hematology
    Yi Zheng; Fiscal Year: 2013
    ..application of molecular and cell therapeutics to transplantable hematopoietic cells, including hematopoietic stem cells, holds the promise of life-long cures for inherited diseases of bone marrow-derived cells...
  80. Signaling pathways regulated by GSK3 in hematopoietic stem cell
    Jian Huang; Fiscal Year: 2013
    ..Investigator/Program Director (Last, First, Middle): Huang, Jian Signaling pathways regulated by GSK3 in hematopoietic stem cells Abstract Hematopoietic stem cells (HSCs) possess two distinct features: the ability to self-renew and to ..
  81. Autologous TGF-B-Modified HSC for Repair of Vasodegenerative Diabetic Retinopathy
    STEPHEN BARTELMEZ; Fiscal Year: 2009
    ..blockade (2-4 days) of endogenous transforming growth factor- beta type 1 (TGF-b1) in murine and human hematopoietic stem cells (HSC and EPCs ) accelerates key functions of these cells including 1) bone marrow engraftment, 2) ..
  82. Epidermal growth factor mitigates radiation-induced hematopoietic failure
    John P Chute; Fiscal Year: 2013
    ..One protein identified was epidermal growth factor (EGF), which is not known to be a growth factor for hematopoietic stem cells (HSCs), but was 18-fold increased in concentration in the BM serum of radioprotected mice compared to ..
  83. Gaucher disease:Treatment of neurodegenerative disease
    Dao Pan; Fiscal Year: 2013
    ..concordant normalization of neurological deficits in an enzyme-deficient LSD murine model after long-term hematopoietic stem cells (HSC)-mediated gene therapy using a lentiviral vector (LV)...
  84. MicroRNA Deregulation in JAK2V617F-positive Chronic Myeloid Neoplasms
    Huichun Zhan; Fiscal Year: 2013
    ..MiRNAs regulate hematopoiesis in both hematopoietic stem cells and committed progenitor cells. MPN is a stem cell disorder...
  85. STEM CELL THERAPY FOR ACUTE KIDNEY INJURY
    Fangming Lin; Fiscal Year: 2013
    ..We have previously shown that freshly isolated mouse hematopoietic stem cells (HSC) can be transplanted and incorporated into regenerating renal tubules...
  86. Transcriptional regulatory mechanisms in B cell development and leukemogenesis
    Robert G Roeder; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Antibody-producing B cells arise from hematopoietic stem cells through a series of developmental steps that involve a hierarchical transcription factor network...
  87. Targeting PML for therapy in leukemia-initiating cells
    Keisuke Ito; Fiscal Year: 2013
    ..that expression of the Promyelocytic Leukemia (PML) tumor suppressor is surprisingly high in both regular hematopoietic stem cells (HSCs) and in CML blasts and that loss of PML expression predicts a more favorable outcome in CML...
  88. Cancer epigenetics: Understanding histone methylation in leukemia stem cells
    Gang Greg Wang; Fiscal Year: 2013
    ..Our preliminary data also suggests that such a novel epigenetic mechanism transforms normal hematopoietic stem cells (HSCs) to leukemia-initiating stem cells (LSCs)...
  89. Calcium Regulation in Osteoclasts
    Leonidas Tsiokas; Fiscal Year: 2013
    ..Osteoclasts are constantly made throughout life from hematopoietic stem cells residing in the bone marrow through a series of complex events involving cytokine signaling and the ..
  90. REGULATION OF RETROOCULAR CONNECTIVE TISSUE
    Terry J Smith; Fiscal Year: 2013
    ..CD34+ fibrocytes are circulating bone marrow derived hematopoietic stem cells. They express the chemokine receptor, CXCR4 and migrate to tissue injury in response to CXCL12...
  91. NLRP1 activation induces deletion of hematopoietic progenitor cells
    BEN ADAM CROKER; Fiscal Year: 2013
    ..C. characterise the role of NLRP1 in hematopoietic stem and progenitor cells during hematopoietic stress induced by infection and chemotherapy, to understand beneficial and pathological roles for NLRP1 activation ..
  92. The synergistic effect of NOTCH, SALL4, and hydrogel on hematopoietic stem cells
    JERELL ROLAND AGUILA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hematopoietic stem cells (HSCs) are rare stem cells that have the ability to differentiate into specialized blood cells, including lymphocytes, red blod cells, and platelets...
  93. An RA immune system derived from patient's stem cells
    Robert Winchester; Fiscal Year: 2013
    ..modeling the human immune system in mice was reported, involving thymic maturation of human bone marrow hematopoietic stem cells in immunodeficient mice receiving partially HLA-matched human fetal thymic tissues to recreate the donor&..
  94. Molecular Mechanisms of Thymic Epithelial Cell Involution in Aging
    Bruce R Blazar; Fiscal Year: 2013
    ..Adoptive transfers of young and old hematopoietic stem cells into young vs old recipients has led to the conclusion that impaired thymopoiesis in the aged is largely ..
  95. Optimizing systemic stem/progenitor cell therapy for AMD
    MARIA BARTOLOMEO GRANT; Fiscal Year: 2013
    ..we have made a number of exciting discoveries: 1) forced expression of the RPE65 gene allows mouse hematopoietic stem cells (mHSC), when injected back into the circulation, to home to the retina and renew the RPE monolayer in ..
  96. The Bone Marrow Niche and Leukemia: Impact of Drugs, Chemicals and Environment
    Robert Snyder; Fiscal Year: 2013
    ..of bone marrow niche biology, including the maturation and differentiation of healthy and leukemogenic hematopoietic stem cells, and the environmental, chemical, and genetic factors involved in the development of myeloid ..
  97. Foamy Viral Gene Therapy for X-linked Severe Combined Immune Deficiency
    David J Rawlings; Fiscal Year: 2013
    ..phenotypic, functional, and molecular analysis in both: 1) a small animal model of SCID-X1 and 2) hematopoietic stem cells (HSC) derived from SCID-X1 patients...
  98. The role of commensal bacteria in enhanced GVHD due to Atg16L1 mutation - Resubmi
    ALEXANDRIA K MAURER; Fiscal Year: 2013
    ..hematopoeitic stem cell transplantation (allo-HSCT) involves transplanting blood- or bone marrow- derived hematopoietic stem cells from a donor into a genetically non-identical recipient of the same species...
  99. Identification of Regulators of Hematopoietic Stem Cells Using Zebrafish Genetics
    Teresa V Bowman; Fiscal Year: 2013
    ..grant is essential for me to reach my ultimate goal of directing an independent research group studying hematopoietic stem cells within their endogenous microenvironments...
  100. Determination of the Mechanisms by which IGFBP-2 Stimulates Bone Remodeling
    CLIFFORD JAMES ROSEN; Fiscal Year: 2013
    ..These interdisciplinary studies will lead to a clearer understanding of the function of IGFBP-2 in the adult skeleton. ..
  101. HEMATOPOIETIC COMMITMENT: MOLECULAR MECHANISMS
    Kyunghee Choi; Fiscal Year: 2013
    ..For example, Runx1 expression in hematopoietic stem cells is regulated by the Ets-GATA-Ebox motif...