eosinophils

Summary

Summary: Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.

Top Publications

  1. pmc Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
    DAVINA WU
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143 0795, USA
    Science 332:243-7. 2011
  2. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
  3. pmc Mepolizumab and exacerbations of refractory eosinophilic asthma
    Pranabashis Haldar
    Institute for Lung Health, Glenfield Hospital, University Hospitals of Leicester National Health Service Trust, Leicester, United Kingdom
    N Engl J Med 360:973-84. 2009
  4. ncbi IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines
    S Molet
    Meakins-Christie Laboratories, McGill University, Montreal, Canada
    J Allergy Clin Immunol 108:430-8. 2001
  5. ncbi Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, ON, Canada
    N Engl J Med 360:985-93. 2009
  6. ncbi Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs
    Wan Seob Cho
    Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Nanotoxicology 6:22-35. 2012
  7. pmc Chitin induces accumulation in tissue of innate immune cells associated with allergy
    Tiffany A Reese
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California San Francisco, San Francisco, California 94143 0795, USA
    Nature 447:92-6. 2007
  8. ncbi Inflammatory subtypes in asthma: assessment and identification using induced sputum
    Jodie L Simpson
    School of Medical Practice and Population Health, Hunter Medical Research Institute, The University of Newcastle, Callaghan, New South Wales, Australia
    Respirology 11:54-61. 2006
  9. ncbi Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
    Ruth H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, LE3 9PQ, Leicester, UK
    Lancet 360:1715-21. 2002
  10. doi Eosinophils: biological properties and role in health and disease
    Simon P Hogan
    Clin Exp Allergy 38:709-50. 2008

Research Grants

Detail Information

Publications371 found, 100 shown here

  1. pmc Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
    DAVINA WU
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143 0795, USA
    Science 332:243-7. 2011
    b>Eosinophils are associated with helminth immunity and allergy, often in conjunction with alternatively activated macrophages (AAMs)...
  2. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
    ..IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils. Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are ..
  3. pmc Mepolizumab and exacerbations of refractory eosinophilic asthma
    Pranabashis Haldar
    Institute for Lung Health, Glenfield Hospital, University Hospitals of Leicester National Health Service Trust, Leicester, United Kingdom
    N Engl J Med 360:973-84. 2009
    ..Preventing exacerbations remains an important goal of therapy. There is evidence that eosinophilic inflammation of the airway is associated with the risk of exacerbations...
  4. ncbi IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines
    S Molet
    Meakins-Christie Laboratories, McGill University, Montreal, Canada
    J Allergy Clin Immunol 108:430-8. 2001
    ..001 and P <.005, respectively). We demonstrated that in addition to T cells, eosinophils in sputum and bronchoalveolar lavage fluids expressed IL-17...
  5. ncbi Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    Parameswaran Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, ON, Canada
    N Engl J Med 360:985-93. 2009
    ..Secondary objectives were to examine its effect on the number of eosinophils in sputum and blood, symptoms, and airflow limitation.
  6. ncbi Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs
    Wan Seob Cho
    Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Nanotoxicology 6:22-35. 2012
    ..The inflammatory cells in the BAL were also different from AEs and NPs with ZnONP and CuONP recruiting eosinophils and neutrophils whilst ZnOAE and CuOAE elicited only mild neutrophilic inflammation that had resolved by four ..
  7. pmc Chitin induces accumulation in tissue of innate immune cells associated with allergy
    Tiffany A Reese
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California San Francisco, San Francisco, California 94143 0795, USA
    Nature 447:92-6. 2007
    ..by infiltration of tissues with interleukin (IL)-4- and IL-13-expressing cells, including T-helper-2 cells, eosinophils and basophils. Tissue macrophages assume a distinct phenotype, designated alternatively activated macrophages...
  8. ncbi Inflammatory subtypes in asthma: assessment and identification using induced sputum
    Jodie L Simpson
    School of Medical Practice and Population Health, Hunter Medical Research Institute, The University of Newcastle, Callaghan, New South Wales, Australia
    Respirology 11:54-61. 2006
    ..The authors sought to investigate the detection of non-eosinophilic asthma using induced sputum. Although this is an important subtype of clinical asthma, its recognition is not standardized...
  9. ncbi Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
    Ruth H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, LE3 9PQ, Leicester, UK
    Lancet 360:1715-21. 2002
    ..We aimed to assess whether a management strategy that minimises eosinophilic inflammation reduces asthma exacerbations compared with a standard management strategy...
  10. doi Eosinophils: biological properties and role in health and disease
    Simon P Hogan
    Clin Exp Allergy 38:709-50. 2008
    b>Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of diverse inflammatory responses, as well as modulators of innate and adaptive immunity...
  11. pmc IgE, mast cells, basophils, and eosinophils
    Kelly D Stone
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
    J Allergy Clin Immunol 125:S73-80. 2010
    IgE, mast cells, basophils, and eosinophils are essential components of allergic inflammation...
  12. ncbi A critical role for eosinophils in allergic airways remodeling
    Alison A Humbles
    Department of Pediatrics, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 305:1776-9. 2004
    ..The contribution of eosinophils, cells associated with asthma and allergy, remains to be established...
  13. ncbi Eosinophil trafficking in allergy and asthma
    Helene F Rosenberg
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Allergy Clin Immunol 119:1303-10; quiz 1311-2. 2007
    ..3 agonists eosinophil transit mediated by specific ligand-receptor interactions, and prolonged survival of eosinophils in peripheral tissues...
  14. ncbi Eosinophils: changing perspectives in health and disease
    Helene F Rosenberg
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 13:9-22. 2013
    b>Eosinophils have been traditionally perceived as terminally differentiated cytotoxic effector cells. Recent studies have profoundly altered this simplistic view of eosinophils and their function...
  15. pmc The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation
    Zhong Jian Shen
    Waisman Center for Developmental Disabilities, The Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
    Nat Immunol 10:257-65. 2009
    ..Here we show, using primary human eosinophils, that in the absence of the prosurvival cytokines granulocyte-macrophage colony-stimulating factor and ..
  16. pmc Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrow
    Kimberly D Dyer
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:4004-9. 2008
    We have devised an ex vivo culture system which generates large numbers of eosinophils at high purity (>90%) from unselected mouse bone marrow progenitors...
  17. ncbi Advances in mechanisms of asthma, allergy, and immunology in 2010
    David H Broide
    Department of Medicine, Section of Allergy and Immunology, University of California at San Diego, Calif, USA
    J Allergy Clin Immunol 127:689-95. 2011
    ..Immunology described advances in our knowledge of cells associated with allergic inflammation (mast cells, eosinophils, dendritic cells, and T cells), as well as IgE, cytokines, receptors, signaling molecules, and pathways...
  18. ncbi Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A
    Anne Gaelle Besnard
    Université de Orléans and CNRS UMR6218, Molecular Immunology and Embryology, 3B rue de la Ferollerie, 45071 Orleans Cedex 2, France
    Am J Respir Crit Care Med 183:1153-63. 2011
    ..IL-22 has both proinflammatory and antiinflammatory properties. Its role in allergic lung inflammation has not been explored...
  19. pmc Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2
    H Hirai
    R and D Center, BML, Saitama 350 1101, Japan
    J Exp Med 193:255-61. 2001
    ..that a seven-transmembrane receptor, CRTH2, which is preferentially expressed in T helper type 2 (Th2) cells, eosinophils, and basophils in humans, serves as the novel receptor for PGD2...
  20. pmc A novel IL-1 family cytokine, IL-33, potently activates human eosinophils
    W Brett Cherry
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minn, USA
    J Allergy Clin Immunol 121:1484-90. 2008
    b>Eosinophils are likely key cells involved in the pathogenesis of asthma and allergic diseases; however, the mechanisms that regulate eosinophil dynamics and functions in mucosal tissues are incompletely understood...
  21. ncbi Defining a link with asthma in mice congenitally deficient in eosinophils
    James J Lee
    Division of Pulmonary Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Science 305:1773-6. 2004
    b>Eosinophils are often dominant inflammatory cells present in the lungs of asthma patients. Nonetheless, the role of these leukocytes remains poorly understood...
  22. pmc Eosinophils: multifaceted biological properties and roles in health and disease
    Hirohito Kita
    Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Immunol Rev 242:161-77. 2011
    b>Eosinophils are leukocytes resident in mucosal tissues. During T-helper 2 (Th2)-type inflammation, eosinophils are recruited from bone marrow and blood to the sites of immune response...
  23. ncbi Role of transforming growth factor-β in airway remodeling in asthma
    Rabih Halwani
    Prince Naif Center for Immunology Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Am J Respir Cell Mol Biol 44:127-33. 2011
    ..cytokine is produced by a number of cells, including macrophages, epithelial cells, fibroblasts, and eosinophils. High expression of TGF-β in patients with asthma was reported by many investigators...
  24. ncbi A comparative study of different methods for the assessment of apoptosis and necrosis in human eosinophils
    G M Walsh
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen Medical School, Forester Hill, UK
    J Immunol Methods 217:153-63. 1998
    b>Eosinophils, prominent cells in asthmatic inflammation, undergo apoptosis or programmed cell death following deprivation of contact with survival-promoting cytokines such as IL-5 and GM-CSF...
  25. ncbi Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils
    Nilda M Munoz
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 278:38813-20. 2003
    ..arachidonic acid (AA) release and leukotriene C4 (LTC4) synthesis in isolated human peripheral blood eosinophils. As low a concentration as 10 nm exogenous hVPLA2 was able to elicit the significant release of AA and LTC4 ..
  26. pmc Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway
    Jennifer Kearley
    Leukocyte Biology Section, National Heart and Lung Institute, Imperial College, London SW7 2AZ, UK
    Am J Respir Crit Care Med 179:772-81. 2009
    ..This represents an important consideration because failure to resolve allergen driven inflammation potentially leads to irreversible airway remodeling, characteristic of chronic asthma...
  27. pmc Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial
    Mona Bafadhel
    Institute for Lung Health, Clinical Sciences Wing, University Hospitals of Leicester, Leicester, UK
    Am J Respir Crit Care Med 186:48-55. 2012
    ..Exacerbations of chronic obstructive pulmonary disease (COPD) and responses to treatment are heterogeneous...
  28. pmc The p110δ subunit of PI3K regulates bone marrow-derived eosinophil trafficking and airway eosinophilia in allergen-challenged mice
    Bit Na Kang
    Laboratory of Allergic Diseases and Inflammation, Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, 55108, USA
    Am J Physiol Lung Cell Mol Physiol 302:L1179-91. 2012
    Trafficking and recruitment of eosinophils during allergic airway inflammation is mediated by the phosphatidylinositol 3-kinase (PI3K) family of signaling molecules...
  29. pmc Eosinophils in innate immunity: an evolving story
    Revital Shamri
    Division of Allergy and Inflammation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Tissue Res 343:57-83. 2011
    b>Eosinophils are innate immune leukocytes found in relatively low numbers within the blood...
  30. pmc Respiratory viruses and eosinophils: exploring the connections
    Helene F Rosenberg
    Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Antiviral Res 83:1-9. 2009
    ..b>Eosinophils are recruited to the lung tissue in response to formalin-inactivated RSV vaccine antigens in humans and in ..
  31. ncbi Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils
    Chun K Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong
    Am J Respir Cell Mol Biol 37:85-96. 2007
    Activation of eosinophils by microbe-derived molecules via Toll-like receptors (TLR) potentially provides the link between microbe-induced innate immune responses and the exacerbation of allergic inflammation...
  32. pmc Exhaled nitric oxide correlates with airway eosinophils in childhood asthma
    T J Warke
    Department of Child Health, Institute of Clinical Science, Queen s University of Belfast, Belfast BT12 6BJ, N Ireland, UK
    Thorax 57:383-7. 2002
    ..The aim of this study was to compare exhaled nitric oxide levels with inflammatory cells and mediators in bronchoalveolar lavage fluid from asthmatic and normal children...
  33. ncbi Basophils are essential initiators of a novel type of chronic allergic inflammation
    Kazushige Obata
    Department of Immune Regulation, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Blood 110:913-20. 2007
    ..The treatment during the progression of the dermatitis resulted in drastic reduction in numbers of infiltrating eosinophils and neutrophils, concomitantly with elimination of basophils from the skin lesions...
  34. ncbi Eosinophils are required for the maintenance of plasma cells in the bone marrow
    Van Trung Chu
    Deutsches Rheuma ForschungsZentrum, Institut der Leibniz Gemeinschaft, Berlin, Germany
    Nat Immunol 12:151-9. 2011
    ..Here we demonstrate that bone marrow eosinophils localized together with plasma cells and were the key providers of plasma cell survival factors...
  35. ncbi Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor
    G Monneret
    Meakins-Christie Laboratories, Department of Medicine, McGill University, Montreal, QC, Canada
    Blood 98:1942-8. 2001
    ..In this study, it is reported that human eosinophils possess this receptor, which would be expected to inhibit their activation...
  36. ncbi The eosinophil
    Marc E Rothenberg
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Annu Rev Immunol 24:147-74. 2006
    b>Eosinophils have been considered end-stage cells involved in host protection against parasites...
  37. ncbi Airway epithelial cells produce neurotrophins and promote the survival of eosinophils during allergic airway inflammation
    Christian Hahn
    Department of Clinical Chemistry and Molecular Diagnostics, Hospital of the University, Philipps University Marburg, Germany
    J Allergy Clin Immunol 117:787-94. 2006
    ..Neurotrophin levels are increased in bronchoalveolar lavage fluid during allergic asthma...
  38. pmc Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo
    Channing Yu
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    J Exp Med 195:1387-95. 2002
    ..immature myeloid cells to three different hematopoietic lineages-erythroid cells, megakaryocytes, and eosinophils. GATA-1 is essential for maturation of erythroid and megakaryocytic precursors, as revealed by gene targeting ..
  39. pmc Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis
    Richard Ahrens
    Division of Allergy and Immunology, Department of Pediatrics, University of Cincinnati College of Medicine, CCHMC, Cincinnati, OH 45229, USA
    J Immunol 181:7390-9. 2008
    ..a link between the eosinophil-selective chemokines, eotaxins (eotaxin-1/CCL11 and eotaxin-2/CCL24), eosinophils, and the inflammatory bowel diseases, Crohn's disease and ulcerative colitis (UC)...
  40. ncbi Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in mice
    Tomohiro Yamada
    Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    FASEB J 25:561-8. 2011
    ..In murine zymosan-induced peritonitis, we found that eosinophils are recruited to the inflamed loci during the resolution phase of acute inflammation...
  41. ncbi IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1
    R P Schleimer
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224
    J Immunol 148:1086-92. 1992
    ..selective mechanisms of leukocyte adhesion in an attempt to understand how preferential recruitment of eosinophils and basophils might occur during allergic and other inflammatory reactions...
  42. pmc The expanding role(s) of eosinophils in health and disease
    Elizabeth A Jacobsen
    Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Blood 120:3882-90. 2012
    Surprisingly, the role(s) of eosinophils in health and disease is often summarized by clinicians and basic research scientists as a pervasive consensus opinion first learned in medical/graduate school...
  43. pmc Cloning, expression, and characterization of the human eosinophil eotaxin receptor
    B L Daugherty
    Department of Inflammation Research, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Exp Med 183:2349-54. 1996
    Although there is a mounting body of evidence that eosinophils are recruited to sites of allergic inflammation by a number of beta-chemokines, particularly eotaxin and RANTES, the receptor that mediates these actions has not been ..
  44. ncbi Endothelium-derived prostaglandin I(2) controls the migration of eosinophils
    Viktoria Konya
    Institute of Experimental and Clinical Pharmacology, Medical University Graz, A 8010 Graz, Austria
    J Allergy Clin Immunol 125:1105-13. 2010
    ..Prostaglandin (PG) I(2) is the major prostanoid released by endothelial cells. Mice deficient in PGI(2) receptors (IPs) show exaggerated eosinophilic inflammation in response to allergen...
  45. pmc Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33
    Tatjana Pecaric-Petkovic
    Institute of Immunology, University Hospital Bern, Inselspital, Bern, Switzerland
    Blood 113:1526-34. 2009
    ..b>Eosinophils are the only other leukocyte-type directly activated by IL-33, as evidenced by screening of p38-activation in ..
  46. ncbi IL-5 and granulocyte-macrophage colony-stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophils
    Barbara A Stout
    Department of Biomolecular Chemistry, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
    J Immunol 173:6409-17. 2004
    ..We report in this study that STAT3, STAT5a, and STAT5b are expressed in human eosinophils and that their signaling pathways are active following IL-5 or GM-CSF treatment...
  47. pmc Detection and quantitation of eosinophils in the murine respiratory tract by flow cytometry
    Whitney W Stevens
    The Carter Immunology Center, UVa Health Sciences Center, Charlottesville, VA 22908, United States
    J Immunol Methods 327:63-74. 2007
    Traditionally, the identification and quantification of eosinophils in inflammatory tissues and exudates has been primarily based upon morphologic criteria and manual counting...
  48. ncbi Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma
    V M Keatings
    Department of Thoracic Medicine, National Heart and Lung Institute, London, United Kingdom
    Am J Respir Crit Care Med 153:530-4. 1996
    ..Studies using bronchoalveolar lavage (BAL) have shown an increased proportion of eosinophils in the BAL fluid from asthmatics compared with that from normal subjects, whereas studies of chronic ..
  49. ncbi Compound exocytosis and cumulative fusion in eosinophils
    Ismail Hafez
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 278:44921-8. 2003
    Focal release of cytotoxic proteins by eosinophils onto the target surface plays an important role in parasite killing...
  50. ncbi A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model
    William R Henderson
    Departments of Medicine and Pathology, University of Washington, Seattle, Washington 98195 6523, USA
    Am J Respir Crit Care Med 165:108-16. 2002
    ..These data suggest an important role for cysteinyl leukotrienes in the pathogenesis of chronic allergic airway inflammation with fibrosis...
  51. ncbi Extranuclear lipid bodies, elicited by CCR3-mediated signaling pathways, are the sites of chemokine-enhanced leukotriene C4 production in eosinophils and basophils
    C Bandeira-Melo
    Department of Medicine, Harvard Thorndike Laboratories, Charles A. Dana Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:22779-87. 2001
    b>Eosinophils and basophils, when activated, become major sources of cysteinyl leukotrienes, eicosanoid mediators pertinent to allergic inflammation...
  52. ncbi Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3
    M Kitaura
    Shionogi Institute for Medical Science, Osaka, Japan
    J Biol Chem 271:7725-30. 1996
    The CC chemokine eotaxin is a selective chemoattractant for guinea pig eosinophils, first purified from bronchoalveolar lavage fluid in a guinea pig model of allergic airway inflammation...
  53. ncbi Thymic stromal lymphopoietin induces chemotactic and prosurvival effects in eosinophils: implications in allergic inflammation
    Chun K Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Am J Respir Cell Mol Biol 43:305-15. 2010
    ..allergic inflammation, we examined the modulating effects of TSLP on human eosinophils. Expression of TSLP receptor complex was detected by RT-PCR, flow cytometry, and Western blot...
  54. ncbi Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity
    Masashi Ikutani
    Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama 930 0194, Japan
    J Immunol 188:703-13. 2012
    ..IL-33 was more effective than IL-25. These cells contribute to maintaining sufficient numbers of lung eosinophils and are important for eosinophil recruitment mediated by IL-25 and IL-33...
  55. pmc Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells
    Elizabeth A Jacobsen
    Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    J Exp Med 205:699-710. 2008
    ..Our studies propose an alternative hypothesis implicating eosinophils in the regulation of pulmonary T cell responses...
  56. ncbi A systematic review and meta-analysis: tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils)
    H L Petsky
    Queensland Children s Respiratory Centre, Royal Children s Hospital, Herston, Brisbane, Queensland 4029, Australia
    Thorax 67:199-208. 2012
    ..Six (2 adults and 4 children/adolescent) studies utilising FeNO and three adult studies utilising sputum eosinophils were included...
  57. pmc Biology of the eosinophil
    Carine Blanchard
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Adv Immunol 101:81-121. 2009
    ..b>Eosinophils have a unique contribution in initiating inflammatory and adaptive responses, due to their bidirectional ..
  58. ncbi IL-5- and eosinophil-mediated inflammation: from discovery to therapy
    Taku Kouro
    Laboratory of Immune Modulation, National Institute of Biomedical Innovation, 7 6 8 Saito Asagi, Ibaraki, Osaka 567 0085, Japan
    Int Immunol 21:1303-9. 2009
    ..Concurrently, IL-5 was recognized as the major maturation and differentiation factor for eosinophils in mice and humans...
  59. ncbi Prostaglandin H2 induces the migration of human eosinophils through the chemoattractant receptor homologous molecule of Th2 cells, CRTH2
    Rufina Schuligoi
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4 A 8010 Graz, Austria
    J Leukoc Biol 85:136-45. 2009
    The major mast cell product PGD2 is released during the allergic response and stimulates the chemotaxis of eosinophils, basophils, and Th2-type T lymphocytes...
  60. pmc Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils
    P D Ponath
    LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
    J Clin Invest 97:604-12. 1996
    ..identified in guinea pigs and also recently in mice, may be a key element for the selective recruitment of eosinophils to certain inflamed tissues...
  61. ncbi Antieosinophilic activity of orazipone
    Hannu Kankaanranta
    The Immunopharmacology Research Group, Medical School B, FIN 33014 University of Tampere, Finland
    Mol Pharmacol 69:1861-70. 2006
    ..3-(4-chloro-3-nitro-benzylidene)-pentane-2,4-dione (OR-2370) reversed interleukin-5-afforded survival of human eosinophils by inducing apoptosis...
  62. ncbi Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages
    David Voehringer
    Howard Hughes Medical Institute, Department of Medicine, University of California San Francisco, San Francisco, California, USA
    J Leukoc Biol 81:1434-44. 2007
    b>Eosinophils are associated with allergic diseases and helminth infections. Development of these cells and recruitment to peripheral tissues are only partially understood...
  63. pmc N-Glycans differentially regulate eosinophil and neutrophil recruitment during allergic airway inflammation
    Nooshin S Bahaie
    Laboratory of Allergic Diseases and Inflammation, Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, Minnesota 55108, USA
    J Biol Chem 286:38231-41. 2011
    Allergic airway inflammation, including asthma, is usually characterized by the predominant recruitment of eosinophils. However, neutrophilia is also prominent during severe exacerbations...
  64. pmc Eosinophils and disease pathogenesis
    Praveen Akuthota
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Semin Hematol 49:113-9. 2012
    b>Eosinophils are granulocytic innate immune cells whose presence is conspicuous in a variety of disease states, including eosinophilic hyperproliferative and infiltrative processes, as well as conditions associated with maladaptive Th2 ..
  65. pmc IL-33 enhances Siglec-8 mediated apoptosis of human eosinophils
    Ho Jeong Na
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Cytokine 57:169-74. 2012
    IL-33 activates eosinophils directly via the ST2 receptor. Like IL-5, IL-33 induces eosinophilia and eosinophilic airway inflammation in mouse models and primes human eosinophil responses...
  66. ncbi A heparan sulfate-facilitated and raft-dependent macropinocytosis of eosinophil cationic protein
    Tan chi Fan
    Department of Life Science, Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan 30013, China
    Traffic 8:1778-95. 2007
    ..Thus, our results define the early events of ECP internalization and may have implications for novel therapeutic design for ECP-associated diseases...
  67. ncbi Human eosinophils express and release IL-13 following CD28-dependent activation
    Gaetane Woerly
    Centre d Immunologie et Biologie Parasitaire, Unité INSERM U547 and IFR17, Institut Pasteur, Lille, France
    J Leukoc Biol 72:769-79. 2002
    Human eosinophils produce a large number of cytokines, including immunoregulatory cytokines...
  68. pmc Protective immune mechanisms in helminth infection
    Robert M Anthony
    The Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Rev Immunol 7:975-87. 2007
    ..In this Review, we examine recent findings regarding the mechanisms of protection in helminth infections that have been elucidated in murine models and discuss the implications of these findings in terms of future therapies...
  69. ncbi CD48 is an allergen and IL-3-induced activation molecule on eosinophils
    Ariel Munitz
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Immunol 177:77-83. 2006
    b>Eosinophils are involved in a variety of allergic, parasitic, malignant, and idiopathic disorders by releasing a variety of factors including specific granule proteins, lipid mediators, and proinflammatory and immunoregulatory cytokines ..
  70. pmc Schistosoma mansoni antigens modulate experimental allergic asthma in a murine model: a major role for CD4+ CD25+ Foxp3+ T cells independent of interleukin-10
    Lucila G G Pacifico
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627, Pampulha, Belo Horizonte, MG, Brazil 31270 901
    Infect Immun 77:98-107. 2009
    ..The number of eosinophils in bronchoalveolar lavage fluid was higher in the asthmatic group than in asthmatic mice infected with S...
  71. pmc Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes
    U Forssmann
    Theodor Kocher Institute, University of Bern, CH 3000 Bern, Switzerland
    J Exp Med 185:2171-6. 1997
    ..Eotaxin-2 induced chemotaxis of eosinophils as well as basophils, with a typically bimodal concentration dependence, and the release of histamine and ..
  72. pmc IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R alpha 2-inhibited pathway
    Li Zuo
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 185:660-9. 2010
    ..However, remodeling occurred independent of eosinophils as demonstrated by eosinophil lineage-deficient, IL-13 transgenic mice...
  73. pmc Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation
    Gen Kano
    Division of Allergy and Immunology, Cincinnati Children s Hospital, and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Allergy Clin Immunol 132:437-45. 2013
    Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is expressed on human eosinophils, where its ligation induces cell death...
  74. pmc Allergen-induced airway remodeling is impaired in galectin-3-deficient mice
    Xiao Na Ge
    Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
    J Immunol 185:1205-14. 2010
    ..an important lectin that promotes airway remodeling via airway recruitment of inflammatory cells, specifically eosinophils, and the development of a Th2 phenotype as well as increased expression of eosinophil-specific chemokines and ..
  75. ncbi Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers
    Andrew Menzies-Gow
    Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College, London, United Kingdom
    J Immunol 169:2712-8. 2002
    ..In this study we examined the capacity of eotaxin and eotaxin-2 to recruit eosinophils and other inflammatory cells in vivo in human atopic and nonatopic skin...
  76. pmc A role for eosinophils in the intestinal immunity against infective Ascaris suum larvae
    Dries Masure
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    PLoS Negl Trop Dis 7:e2138. 2013
    ..Further analysis showed that eosinophils degranulated in vitro in response to contact with infective Ascaris larvae in the presence of serum from both ..
  77. pmc The fluorescein-derived dye aminophenyl fluorescein is a suitable tool to detect hypobromous acid (HOBr)-producing activity in eosinophils
    Jorg Flemmig
    Institute for Medical Physics and Biophysics, Medical Faculty, University of Leipzig, Härtelstrasse 16 18, 04107 Leipzig, Germany
    J Biol Chem 287:27913-23. 2012
    ..Finally, peroxidase activities were successfully detected in phorbol ester-stimulated neutrophils and eosinophils using flow cytometry. Thereby inhibitory studies confirmed the peroxidase-dependent oxidation of APF...
  78. pmc Sputum eosinophilia can predict responsiveness to inhaled corticosteroid treatment in patients with overlap syndrome of COPD and asthma
    Yoshiaki Kitaguchi
    First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Int J Chron Obstruct Pulmon Dis 7:283-9. 2012
    ..It was hypothesized that patients with overlap syndrome may have different clinical characteristics such as sputum eosinophilia, and better responsiveness to treatment with inhaled corticosteroid (ICS)...
  79. pmc BLTR mediates leukotriene B(4)-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis
    A M Tager
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Exp Med 192:439-46. 2000
    ..LTB(4)) is a potent chemoattractant active on multiple leukocytes, including neutrophils, macrophages, and eosinophils, and is implicated in the pathogenesis of a variety of inflammatory processes...
  80. ncbi Immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidase
    Elizabeth Forbes
    Allergy and Inflammation Research Group, Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
    J Immunol 172:5664-75. 2004
    ..In this study, we have used a mouse model of UC to establish a central role for eotaxin and, in turn, eosinophils in the development of the immunopathogenesis of this disease...
  81. pmc Intracellular signaling mechanisms regulating the activation of human eosinophils by the novel Th2 cytokine IL-33: implications for allergic inflammation
    Joyce Y S Chow
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China
    Cell Mol Immunol 7:26-34. 2010
    ..In the present study, we characterized the activation of human eosinophils by IL-33, and investigated the underlying intracellular signaling mechanisms...
  82. ncbi Anti-inflammatory effects of limonene from yuzu (Citrus junos Tanaka) essential oil on eosinophils
    Ryoji Hirota
    Dept of Environmental Medicine, Kochi Medical School, Kohasu, Oko, Nankoku, Kochi 783 8505, Japan
    J Food Sci 75:H87-92. 2010
    ..These results suggest that limonene may have potential anti-inflammatory efficacy for the treatment of bronchial asthma by inhibiting cytokines, ROS production, and inactivating eosinophil migration...
  83. ncbi Endothelial protein C receptor-dependent inhibition of human eosinophil chemotaxis by protein C
    Clemens Feistritzer
    Division of General Internal Medicine, Department of Internal Medicine, University of Innsbruck, Innsbruck, Austria
    J Allergy Clin Immunol 112:375-81. 2003
    ..Eosinophil infiltration is a characteristic feature of allergic inflammation. Allergic responses are associated with local activation of the coagulation pathway and accumulation of fibrin...
  84. ncbi Role of atopic status in Toll-like receptor (TLR)7- and TLR9-mediated activation of human eosinophils
    Anne Mansson
    Laboratory of Clinical and Experimental Allergy Research, Department of Otorhinolaryngology, Malmo University Hospital, Lund University, Malmo, Sweden
    J Leukoc Biol 85:719-27. 2009
    ..The mechanisms behind this are not known, but a virus-induced activation of eosinophils through TLRs could be involved...
  85. pmc MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers
    Thomas X Lu
    Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Allergy Clin Immunol 129:1064-75.e9. 2012
    ..The role of microRNAs (miRNAs), a key class of regulators of mRNA expression and translation, in patients with eosinophilic esophagitis (EoE) has not been explored...
  86. ncbi Oral corticosteroids decrease eosinophil and CC chemokine expression but increase neutrophil, IL-8, and IFN-gamma-inducible protein 10 expression in asthmatic airway mucosa
    Motonori Fukakusa
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 115:280-6. 2005
    ..Inhaled corticosteroids have been shown to decrease the number of eosinophils and to downregulate T H 2 cytokines but to increase neutrophils...
  87. ncbi Inflammatory subtypes in asthma are related to airway hyperresponsiveness to mannitol and exhaled NO
    Celeste Porsbjerg
    Respiratory and Allergy Research Unit, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen, NV, Denmark
    J Asthma 46:606-12. 2009
    Asthma may be defined as eosinophilic or non-eosinophilic based on the presence of eosinophils in sputum. Recently a further classification into four inflammatory subtypes has been suggested...
  88. ncbi Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia
    E A Garcia-Zepeda
    Infectious Disease Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Med 2:449-56. 1996
    ..early response gene of cytokine-stimulated epithelial and endothelial cells, and is induced in peripheral blood eosinophils by interleukin-3. Eotaxin is directly chemotactic for eosinophils, but not mononuclear cells or neutrophils...
  89. pmc Major basic protein from eosinophils and myeloperoxidase from neutrophils are required for protective immunity to Strongyloides stercoralis in mice
    Amy E O'Connell
    1Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Infect Immun 79:2770-8. 2011
    b>Eosinophils and neutrophils contribute to larval killing during the primary immune response, and neutrophils are effector cells in the secondary response to Strongyloides stercoralis in mice...
  90. ncbi A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils
    M R Logan
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, AB, Canada, and Department of Medicine and Immunology, Mayo Clinic, Rochester, MN, USA
    Allergy 61:777-84. 2006
    ..Vesicle-associated membrane proteins-7 and -8 have been implicated in endosome/lysosome trafficking, however, their role in granulocyte exocytosis remains obscure...
  91. ncbi Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood
    Olga E M Savenije
    Departments of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Allergy Clin Immunol 127:750-6.e1-5. 2011
    ..Single nucleotide polymorphisms (SNPs) in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies...
  92. ncbi The usefulness of biomarkers of airway inflammation in managing asthma
    Sarita U Patil
    Divsion of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Allergy Asthma Proc 31:259-68. 2010
    ..Enumeration of sputum eosinophils is very useful in guiding changes in controller medication to decrease asthma exacerbations, whereas ..
  93. pmc Eosinophils and allergic airway disease: there is more to the story
    Elizabeth R Walsh
    Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Trends Immunol 31:39-44. 2010
    ..In this review, we discuss recent advances that suggest that eosinophils can present antigen to naïve as well as to antigen-experienced T cells, induce T helper 2 cell development, ..
  94. ncbi Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production
    Andre Gessner
    Institute of Clinical Microbiology, Immunology, and Hygiene University of Erlangen Nurnberg, Erlangen, Germany
    J Immunol 174:1063-72. 2005
    Mast cells, basophils, and eosinophils are myeloid cells that are distinguished by their capability to produce IL-4 and IL-13. However, it is not clear how this potential is related to the lineage differentiation of these subsets...
  95. pmc Mouse eosinophils possess potent antibacterial properties in vivo
    Stefanie N Linch
    Oregon Health and Science University, Division of Pulmonary and Critical Care Medicine, 3181 SW Sam Jackson Park Rd, Mail Code UHN67, Portland, OR 97239, USA
    Infect Immun 77:4976-82. 2009
    b>Eosinophils are best known as the predominant cellular infiltrate associated with asthma and parasitic infections...
  96. ncbi Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways
    I Sabroe
    Leukocyte Biology Section, Biomedical Sciences Division, Imperial College School of Medicine, South Kensington, London, United Kingdom
    J Immunol 162:2946-55. 1999
    ..protein-1alpha (MIP-1alpha), and IL-8 on leukocytes in mixed cell suspensions and focused on the responses of eosinophils to C-C chemokines...
  97. ncbi Interaction of eosinophils with endothelial cells is modulated by prostaglandin EP4 receptors
    Viktoria Konya
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Eur J Immunol 41:2379-89. 2011
    ..EP4 agonist prevented the activation and cell-surface clustering of β2 integrins, and L-selectin shedding of eosinophils. Under physiological flow conditions, eosinophils that were treated with the EP4 agonist showed reduced ..
  98. pmc Molecular and functional characterization of Hv1 proton channel in human granulocytes
    Gábor L Petheo
    Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    PLoS ONE 5:e14081. 2010
    ..In summary, beside monomers native H(v)1 forms stable proton channel dimer in resting and activated human granulocytes. The expression pattern of H(v)1 in granulocytes is optimized to support intense NADPH oxidase activity...
  99. ncbi The purinergic receptor P2Y2 receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation
    T Muller
    Department of Pneumology, University Medical Centre Freiburg, Freiburg, Germany
    Allergy 65:1545-53. 2010
    ..Extracellular ATP contributes to the pathogenesis of asthma via signalling at purinergic receptors. However, the precise purinergic receptors subtypes mediating the pro-asthmatic effects of ATP have not been identified, yet...
  100. ncbi Formyl peptide receptor-like 2 is expressed and functional in plasmacytoid dendritic cells, tissue-specific macrophage subpopulations, and eosinophils
    Thalie Devosse
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, Universite Libre de Bruxelles, Brussels, Belgium
    J Immunol 182:4974-84. 2009
    ..FPRL2 is also expressed in eosinophils, which are recruited but do not degranulate in response to F2L...
  101. ncbi Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective
    Leslie R Bisset
    Swiss National Center for Retroviruses, University of Zurich, Zurich, Switzerland
    Curr Opin Pulm Med 11:35-42. 2005
    ..Based on a series of selected references published during the last year, this review now summarizes recent advances and discusses the likely implications of these findings...

Research Grants69

  1. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..to the systemic inflammatory response through the production of, and recirculation of, TH2-like lymphocytes, eosinophils, basophils, and fibrocytes;and that those cells in turn influence sinus associated lymphatic tissue, bone ..
  2. Targeting Galectin-3 with novel drugs for treatment of eczema
    Fu Tong Liu; Fiscal Year: 2010
    ..involving multiple immunologic and inflammatory pathways that include T cells, dendritic cells, mast cells and eosinophils, as well as keratinocytes...
  3. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
    ..antigen, Th2 cells produce cytokines that regulate IgE synthesis (IL-4 and IL-13), and growth and activation of eosinophils (IL-5) and mast cells (IL-3 and IL-4). IL-13 and IL-9 control mucus production and AHR...
  4. Neural mechanisms by which chronic stress regulates inflammation in asthma
    Melissa A Rosenkranz; Fiscal Year: 2013
    ..metabolic rate will be examined in relation to measures of lung function (FEV1), inflammation (sputum and blood eosinophils, exhaled nitric oxide), sensitivity of immune cells to inhibition by glucocorticoids, stress responsivity (..
  5. Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
    LAURA ELISE CROTTY ALEXANDER; Fiscal Year: 2013
    ..Dendritic cells, eosinophils, and mast cells are known to play a role in the development and progression of asthma, however the molecular ..
  6. Eosinophil ORMDL3 and allergic inflammation
    P Sriramarao; Fiscal Year: 2012
    ..b>Eosinophils (Eos) are one of the most proinflammatory granulocytes that contribute to the pathogenesis and exacerbation of ..
  7. TNF Family Members and Control of Fibrotic Disease
    Michael Croft; Fiscal Year: 2013
    ..by deregulation of epithelial cells, macrophages, and fibroblasts, and inflammatory cells such as Th2 cells and eosinophils may play roles in promoting the activity of these cell types...
  8. Anti- IL5 therapy for Churg-Strauss Syndrome: a double blind randomized, placebo-
    Michael E Wechsler; Fiscal Year: 2010
    ..Characterized by significant tissue infiltration by eosinophils, it has become increasingly clear that CSS may be due to dysregulation of eosinophil function and/or production...
  9. Cellular interactions in asthma
    CHRISTOPHER DAVID CABALLERO ALLEN; Fiscal Year: 2012
    ..The particular cell types of interest will be mast cells, basophils, eosinophils, neutrophils, macrophages, monocytes, dendritic cells, T cells, and B cells...
  10. Targeting Siglec-8/-F to treat eosinophil and mast cell related disorders
    Bruce S Bochner; Fiscal Year: 2012
    ..provided by applicant): In anaphylaxis, asthma and other forms of acute and chronic allergic diseases, eosinophils and mast cells, through release of preformed and newly generated mediators, granule proteins, and cytokines, ..
  11. Targeting Siglec-8/-F to treat eosinophil and mast cell related disorders
    Bruce S Bochner; Fiscal Year: 2013
    ..provided by applicant): In anaphylaxis, asthma and other forms of acute and chronic allergic diseases, eosinophils and mast cells, through release of preformed and newly generated mediators, granule proteins, and cytokines, ..
  12. IMMUNOLOGIC BASIS OF RESISTANCE AND HYPERSENSITIVITY
    KARL FRANK AUSTEN; Fiscal Year: 2012
    ..LIRs) with ITIM motifs to attenuate the activation of mouse mast cells and PMNs and human basophils and eosinophils;RNA-binding proteins such as TIA and TIAR, that serve as translational repressers in the balance between cell ..
  13. Eotaxin in Colitis and Colitis-Associated Carcinogenesis
    Lori A Coburn; Fiscal Year: 2013
    ..Eotaxin-1 (CCL11) is a chemoattractant for eosinophils. When the cytokine and chemokine profiles in this cohort of 40 controls and 137 UC patients were defined, there ..
  14. TGF-BETA, CHLORIDE CHANNELS AND MIGRATION OF EOSINOPHILS
    Devendra K Agrawal; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Migration of eosinophils in the lung in response to repeated allergen exposure is associated with airway remodeling in chronic asthma...
  15. A Mucosal RSV Vaccine
    Kejian Yang; Fiscal Year: 2013
    ..characterized by a skewed CD4+ T-cell response (in the absence of neutralizing antibodies) and the influx of eosinophils in the lung were detected...
  16. Sulfotransferases in the Synthesis of L-Selectin Ligands
    Steven D Rosen; Fiscal Year: 2010
    ..This Siglec is present on eosinophils and can induce apoptosis when artificially cross-linked by antibodies...
  17. INFIDELITY OF CYTOSINE METHYLATION AND HUMAN CANCER
    Lawrence C Sowers; Fiscal Year: 2013
    ..using in vitro and model systems, we established that reactive molecules generated by activated neutrophils and eosinophils can generated an array of DNA adducts...
  18. Cpdm: Cloning a Gene That Regulates Eosinophil Function
    JOHN PAUL SUNDBERG; Fiscal Year: 2013
    ..A prominent feature of the cpdm phenotype is chronic dermatitis with many eosinophils and overexpression of type 2 cytokines along with a diminished systemic type 1 immune response...
  19. MOLECULAR PATHOLOGY OF CHRONIC LUNG DISEASE
    Craig Gerard; Fiscal Year: 2013
    ..We will map quantitative trait loci (QTLs) and potential candidate genes regulating the contribution of eosinophils to airway hyperresponsiveness and generation of a Th2 resonse by crossing ?dblGATA knockout mice on the C5lBL/6 ..
  20. INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMS
    Marcia B Goldberg; Fiscal Year: 2012
    ..response;(5) epidemiology, including pharmacoepidemiology and nosocomial infections;(6) cell biology of eosinophils and basophils;(7) biochemistry of proteins, carbohydrates, and lipids;(8) molecular biology and genetics;and (9)..
  21. The Role of IgE in Autoimmune Skin Diseases
    Janet A Fairley; Fiscal Year: 2013
    ..the surface of epidermal keratinocytes or to its high affinity receptor, Fc5RI, on mast cells and potentially eosinophils. These molecular interactions then trigger a pro-inflammatory response in the keratinocytes, eosinophil ..
  22. TSLP and Childhood Asthma
    Steven F Ziegler; Fiscal Year: 2012
    ..play a triggering role in the activation and/or recruitment of IgE antibody-producing B cells, mast cells and eosinophils, i.e. the cellular triad involved in the allergic inflammation...
  23. Role of mesenteric lymphatics and dietary endotoxin in metabolic syndrome
    DAVID CARL ZAWIEJA; Fiscal Year: 2013
    ..Our preliminary data show that immune cells, eosinophils and neutrophils are present on or adjacent to the lymphatic wall, and that the number of these immune cells on ..
  24. Exploiting Protease-Activatable Agents to Characterize and Treat Asthma
    Csilla Felsen; Fiscal Year: 2013
    ..provided by applicant): Asthma is an airway disease characterized by inflammation;accumulation of mast cells, eosinophils, and neutrophils;and intermittent, reversible airway obstruction that affects more than 300 million people ..
  25. MECHANISMS OF PULMONARY FIBROSIS
    Sem H Phan; Fiscal Year: 2010
    ..potentially important source of such cytokines in these fibrotic lesions, thus identifying a potential role for eosinophils in fibrogenesis...
  26. 15-lipoxygenase regulation of mucosal immunity in allergic airways disease
    Douglas A Kuperman; Fiscal Year: 2011
    ..This is concerning because IgA binding to eosinophils induces their degranulation...
  27. Perinatal exposure to environmental estrogens and asthma pathogenesis
    Terumi Midoro Horiuti; Fiscal Year: 2010
    ..Cells of the innate immune system (mast cells, basophils and eosinophils) contribute directly to the allergic inflammation and can promote the differentiation to the T helper type 2 (..
  28. The role of SP-A in Mp-induced exacerbations during allergic airway disease.
    JULIE GUNNELLS LEDFORD; Fiscal Year: 2013
    ..SP-A is mediating TNF-? production and mast cell responses during Mp infection;2) the role of mast cells and eosinophils and their respective contributions of TNF-? in Mp infected allergic airways (Ova + Mp) and 3) the functionality ..
  29. Eosinophil Peroxidase in Allergic Inflammation
    Arne Slungaard; Fiscal Year: 2012
    ..We believe this is possible because thiocyanate blunts tissue damage caused by eosinophils, a type of white cell that causes allergic symptoms and diseases...
  30. Cyclophilin-CD147 interaction in autoimmune arthritis
    Stephanie L Constant; Fiscal Year: 2010
    ..For example, cyclophilin A is a potent chemotactic agent for human T lymphocytes, eosinophils, monocytes, and neutrophils...
  31. ACUTE AIRWAY EFFECTS OF TLR7 AND TLR8 STIMULATION IN HEALTH AND DISEASE
    David B Jacoby; Fiscal Year: 2013
    ..Since these TLRs are on parasympathetic nerves, as well as on eosinophils recruited to the airway nerves, we will also test whether TLR7 and TLR8 change neural control in sensitized ..
  32. Regulation of ITK in Lung Allergy
    Constantine D Tsoukas; Fiscal Year: 2010
    ..The symptoms underlying this disease involve IgE antibodies, infiltration of lungs by lymphocytes and eosinophils, secretion of mucous, and hyperactivity of the bronchial smooth muscle...
  33. Molecular Mechanisms of IL-4 and IL-13 Signaling
    Achsah D Keegan; Fiscal Year: 2010
    ..and basophils upon cross-linkage of the high affinity receptor for immunoglobulin E (IgE), and by activated eosinophils. These two cytokines elicit similar responses in vitro, many of which are associated with allergy and asthma...
  34. Regulation of Myeloid Development and Function by II-4
    Achsah D Keegan; Fiscal Year: 2010
    ..is produced by TH2 lymphocytes, NKT cells, and by cells of the innate immune system including mast cells, and eosinophils. It was originally identified as a stimulator of B cell proliferation, but it is now clear that IL-4 can ..
  35. Peptide-based nanoparticle inhibition of CCR3-mediated inflammatory cell recruitm
    Vadim V Gaponenko; Fiscal Year: 2013
    ..Recent studies indicate that targeting eosinophils in patients with properly diagnosed eosinophilic asthma can provide a significant health benefits...
  36. RELM-alpha regulation of hookworm-induced lung inflammation
    MEERA GOH NAIR; Fiscal Year: 2013
    ..that is associated with RELMa expression by epithelial cells, alternatively activated macrophages and eosinophils. Further, RELMa-deficient (Retnla-/-) mice exhibited exacerbated chronic lung inflammation, and increased ..
  37. Transgenerational Susceptibility to Asthma from Air Pollution Exposure
    Lester Kobzik; Fiscal Year: 2013
    ..For all 3 generations, we will measure allergic airway inflammation (BAL eosinophils, cytokines, histology) and airway hyperresponsiveness (AHR) after an intentionally sub-optimal allergen (..
  38. Role of Spi-C in eosinophil development and functional responses
    PATRICIA CHANDHOK FULKERSON; Fiscal Year: 2013
    ..b>Eosinophils are derived from lineage-committed hematopoietic progenitor cells expressing the transcription factor GATA-1 ..
  39. Biological roles of galectins
    GERARDO RAUL VASTA; Fiscal Year: 2013
    ..have led to propose that galectins mediate developmental processes, whereas their expression in macrophages, eosinophils and basophils suggests, and their recently established recognition properties for microbes, suggest their ..
  40. Eosinophils and lung immunity to Pneumocystis
    Chad Steele; Fiscal Year: 2013
    ..murina lung infection. In turn, we demonstrate in a pilot study that mice lacking eosinophils (dbl GATA1 deficient mice) have impaired P. murina lung clearance...
  41. Interplay between LTE4/LTE4 receptors and IFN-y with mast cells and eosinophils i
    Larry C Borish; Fiscal Year: 2013
    ..We will investigate the interaction of LUVA conditioned medium (LCM) with eosinophils to further define mechanisms central to the pathophysiology of AERD...
  42. Eosinophil:M2 Macrophage:CCL11 Axis in Experimental Colitis and Pediatric Cortico
    SIMON PATRICK HOGAN; Fiscal Year: 2013
    ..In experimental studies, we have identified a link between calprotectin, M[unreadable]-derived CCL11, and eosinophils in experimental colitis...
  43. The function of the NKT cell determinant, PLZF, in mucosal lymphocytes.
    DEREK B SANT apos ANGELO; Fiscal Year: 2010
    ..in resting, activated or differentiated conventional T cells, NK cells, B cells, macrophages, neutrophils or eosinophils. In sharp contrast, in the gut, PLZF is expressed in a variety of different lymphocytes including CD8aa T cells,..
  44. BIOCHEMICAL PATHWAYS OF 12-HETE AND 12-KETE METABOLISM
    Joshua Rokach; Fiscal Year: 2010
    ..Its potent effects on eosinophils suggest that it may play a role in allergic diseases such as asthma...
  45. Secretory Phospholipase A2s in Airway Pathophysiology
    Teal S Hallstrand; Fiscal Year: 2013
    ..Further, we found that sPLA2-X initiates LT synthesis in target cells including eosinophils and mast cells implicated in asthma...
  46. Eosinophilic Myocarditis
    Noel R Rose; Fiscal Year: 2013
    ..Both strains of mice develop severe myocarditis with more than 30% of their heart infiltrate comprised by eosinophils. Based on these observations, we propose the overarching hypothesis that Th2-driven inflammation, especially ..
  47. Role and Activation Status of IRS1/2 in IL-4-induced Protection from Cell Death.
    HOLLY A PORTER; Fiscal Year: 2010
    ..mainly by TH2 cells, basophils, and mast cells, but is also expressed by NK T cells, gamma/delta T cells, and eosinophils. There are two main signaling pathways activated by IL-4;the STAT6, signal transducers and activators of ..
  48. Phase II studies of gamma tocopherol as an intervention for environmental asthma
    David B Peden; Fiscal Year: 2013
    ..In challenge studies of AAs, we have shown that LPS and O3 induces influx of neutrophils (PMNs) and eosinophils in AAs as well as augmenting response to inhaled allergens...
  49. TSLP and the Pathophysiology of Asthma
    Steven F Ziegler; Fiscal Year: 2013
    ..play a triggering role in the activation and/or recruitment of IgE antibody-producing B cells, mast cells and eosinophils, i.e. the cellular triad involved in the allergic inflammation...
  50. Obesity and Allergic Airway Hyperresponsiveness
    RICHARD ALAN JOHNSTON; Fiscal Year: 2013
    ..exhibit increased airway responsiveness to methacholine but decreased numbers of bronchoalveolar lavage fluid eosinophils. Recent data from humans demonstrate that obesity does not promote the development of airway ..
  51. Regional B Cells Modulate Airway Th2 Responses
    CRAIG MICHAEL SCHRAMM; Fiscal Year: 2010
    ..is an inflammatory disease of the airways, involving antigen-presenting cells, T lymphocytes, mast cells and eosinophils. B lymphocytes have traditionally been viewed as target cells for Th2 cytokines;however, emerging evidence ..
  52. CYTOPLASMIC LIPID BODIES OF INFLAMMATORY CELLS
    Peter F Weller; Fiscal Year: 2013
    ..provided by applicant): Lipid bodies are cytoplasmic inclusions that develop in leukocytes, including eosinophils and mast cells, associated with allergic inflammation...
  53. Risk Factors and Biomarkers for Diagnosis &Treatment of Eosinophilic Esophagitis
    EVAN SAMUEL DELLON; Fiscal Year: 2013
    ..EoE is a rapidly emerging clinicopathologic entity defined by abnormal infiltration of eosinophils into the esophageal mucosa that leads to dysphagia, progressive esophageal stenosis, and food impaction...
  54. Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology
    JAMES WAVELL AIKEN; Fiscal Year: 2013
    ..pathologic outcomes of type 2 immunity, and are characterized by infiltration of tissues with Th2 cells and eosinophils, by elevations in serum IgE, and by alterations in epithelial and mucosal biology...
  55. Regulation of TSLP-Mediated Skin Inflammation
    Steven F Ziegler; Fiscal Year: 2013
    ..biased Th2 response, elevated serum levels of IgE, and severe dermal infiltration T cells, mast cells and eosinophils. Surprisingly, TSLP-overexpressing mice lacking T cells still develop the characteristic cutaneous inflammation,..
  56. Role of Memory T Cells in Pathogenesis and Resolution of Inflammatory Diseases
    Richard B Bankert; Fiscal Year: 2010
    ..goblet cell hyperplasia, subepithelial fibrosis and by the infiltration of inflammatory cells including eosinophils, neutrophils, macrophages, plasma cells and lymphocytes...
  57. The Effect of Bromelain on CD4+ T Cell Function in Asthma
    ERIC RICHARD SECOR; Fiscal Year: 2012
    ..effects in an ovalbumin (OVA)-induced mouse model of allergic airway disease (AAD) via reduced CD4+ T cells, eosinophils, and Th2 cytokines...
  58. Parasite Immunity Orchestrated by Th2 Cells
    Richard M Locksley; Fiscal Year: 2013
    ..helminths elicit host immune responses characterized by infiltration of tissues vi/ith Th2 cells, basophils and eosinophils, and the generation of high IgE in serum...
  59. Eosinophils support nematode infection
    Judith A Appleton; Fiscal Year: 2012
    ..Our objective is to challenge the paradigm that eosinophils function exclusively as effector cells that attack parasitic worms...
  60. IL-13 Associated Eosinophil Lung Responses
    Marc E Rothenberg; Fiscal Year: 2013
    ..applicant): Clinical and experimental investigations have demonstrated a strong correlation between Th2 cells, eosinophils and allergic lung disease severity suggesting an integral role for both of these cells in asthma...
  61. REGULATION OF GASTROINTESTINAL EOSINOPHILS
    Marc E Rothenberg; Fiscal Year: 2013
    ..Over the past 9 years, we have been funded by the NIAID to study the regulation and role of murine GI eosinophils at baseline and in allergic inflammatory states...
  62. Molecular Mechanisms for IL-25-mediated Th2 Responses
    Xiaoxia Li; Fiscal Year: 2010
    ..produced by both the structural cells of the lung as well as the infiltrating CD4+ lymphocytes, eosinophils, and basophils and the resident mast cells, leading to progressive loss of lung function...
  63. EOSINOPHIL APOPTOSIS IN ASTHMA
    Gerald Litwack; Fiscal Year: 2001
    b>Eosinophils are known to be important effector cells in the pathogenesis of asthma...
  64. MOLECULAR BIOLOGY AND FUNCTIONS OF EOSINOPHIL PROTEINS
    Steven Ackerman; Fiscal Year: 2005
    ..considerations alone (CLC is 10 percent of eosinophil protein), but also its secretion by activated eosinophils, elevated blood levels in patients with eosinophilia, and increased levels in sputum and BAL of asthmatics, all ..
  65. LEUKOCYTE ADHESION IN ALLERGIC INFLAMMATION
    P Sriramarao; Fiscal Year: 2009
    ..is a complex disease that involves the trafficking and mobilization of multiple leukocytes, including eosinophils and T-cells, to sites of inflammation...
  66. C3A ACTIVATION OF LEUKOCYTES IN INFLAMMATION
    TONY HUGLI; Fiscal Year: 2002
    ..Extensive evidence indicates that neutrophils, monocytes and eosinophils are attracted to sites of inflammation by specific chemotactic factors, including complement factors such as ..
  67. ANTIVIRAL EFFECTS OF EOSINOPHILS IN THE LUNGS
    David Jacoby; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Viral infections can be associated with activation of eosinophils, especially in the airways of patients with asthma...
  68. IN VITRO STUDIES OF THE MECHANISM OF ANAPHYLAXIS
    FRANK AUSTEN; Fiscal Year: 1999
    The proposed investigations on the cells, mast cells and eosinophils, and the mediators, preformed secretory granule constituents and newly derived membrane lipid metabolites, of immediate hypersensitivity reactions continue a long term ..
  69. Airway Eosinophil Activation by Anticholinergic Therapy
    David Jacoby; Fiscal Year: 2009
    ..We hypothesize that anticholinergic medications block muscarinic receptors on eosinophils that normally function to limit eosinophil activation...