Genomes and Genes
Summary: Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS.
Publications376 found, 100 shown here
- Conditional gene targeting in macrophages and granulocytes using LysMcre miceB E Clausen
Institute for Genetics, University of Cologne, Germany
Transgenic Res 8:265-77. 1999..target genes tested, a deletion efficiency of 83-98% was determined in mature macrophages and near 100% in granulocytes. Partial deletion (16%) could be detected in CD11c+ splenic dendritic cells which are closely related to the ..
- Subsets of myeloid-derived suppressor cells in tumor-bearing miceJe In Youn
H Lee Moffitt Cancer Center and Research Institute and Department of Molecular Medicine, University of South Florida, Tampa, FL 33612, USA
J Immunol 181:5791-802. 2008..These data indicate that suppressive features of MDSC is caused not by expansion of a specific subset but more likely represent a functional state of these cells...
- Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytesAnnette T Hastie
Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 125:1028-1036.e13. 2010Patients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma.
- Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patientsJ Schmielau
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Cancer Res 61:4756-60. 2001..We observed that in samples from patients only, an unusually large number of granulocytes copurify with low density PBMCs on a density gradient rather than sediment, as expected, to the bottom of the ..
- Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytesPaulo C Rodriguez
Department of Microbiology, Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
Cancer Res 69:1553-60. 2009..These results may provide new insights on the mechanisms of tumor-induced anergy/tolerance and may help explain why some immunotherapies fail to induce an antitumor response...
- Morphologic and functional characterization of granulocytes and macrophages in embryonic and adult zebrafishG J Lieschke
Ludwig Institute for Cancer Research, The Royal Melbourne Hospital, Parkville, Victoria, Australia
Blood 98:3087-96. 2001..The morphology and function of zebrafish myeloid cells were characterized. Adult zebrafish contain 2 distinct granulocytes, a heterophil and a rarer eosinophil, both of which circulate and are generated in the kidney, the adult ..
- Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1T Nagasawa
Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Japan
Nature 382:635-8. 1996..In addition, the mutants had a cardiac ventricular septal defect. Hence, we have shown that the chemokine PBSF/SDF-1 has several essential functions in development...
- Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factorYoka H Kusumanto
Department of Medical Oncology, University Hospital Groningen, Groningen, The Netherlands
Angiogenesis 6:283-7. 2003..namely 58% in healthy volunteers and 69% in patients with cancer of the total circulating VEGF is contained in granulocytes, particular in the neutrophils, as confirmed by fluorescence-activated cell sorting (FACS)...
- Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cellsV Bronte
Department of Oncology and Surgical Sciences, Padua University, Padova, Italy
Blood 96:3838-46. 2000..Blood. 2000;96:3838-3846)..
- Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alphaPu Zhang
Harvard Institutes of Medicine, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Immunity 21:853-63. 2004..Therefore, C/EBP alpha is not only essential for granulocyte development but, in addition, is a regulator of hematopoietic stem cell activity...
- Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1R Tedjo Sasmono
CRC for Chronic Inflammatory Diseases and ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia
J Leukoc Biol 82:111-23. 2007..In this paper, we show that the EGFP reporter is also expressed in all granulocytes detected with the Gr-1 antibody, which binds to Ly-6C and Ly-6G or with a Ly-6G-specific antibody...
- Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishmentYoshinori Nagai
Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
Immunity 24:801-12. 2006..Thus, the preferential pathogen-mediated stimulation of myeloid differentiation pathways may provide a means for rapid replenishment of the innate immune system during infection...
- Nuclear localization of peptidylarginine deiminase V and histone deimination in granulocytesKatsuhiko Nakashima
Graduate School of Integrated Science, Yokohama City University, 22 2 Seto, Kanazawa Ku, Yokohama 236 0027, Japan
J Biol Chem 277:49562-8. 2002..We studied the subcellular distribution of PAD V in HL-60 granulocytes and peripheral blood granulocytes...
- Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytesMarcin Kowanetz
Genentech Inc, South San Francisco, CA 94080, USA
Proc Natl Acad Sci U S A 107:21248-55. 2010..we examined overexpress granulocyte-colony stimulating factor (G-CSF), which expands and mobilizes Ly6G+Ly6C+ granulocytes and facilitates their subsequent homing at distant organs even before the arrival of tumor cells...
- Toll-like receptor 2 deficiency delays pneumococcal phagocytosis and impairs oxidative killing by granulocytesMaryse Letiembre
Division of Infectious Diseases, Department of Research, University Hospital, Hebelstrasse 20, CH 4031 Basel, Switzerland
Infect Immun 73:8397-401. 2005..These cells exhibited also a lower oxidative bactericidal activity against S. pneumoniae than WT PMN, suggesting that TLR2 modulates bacterial clearance in PMN...
- Microscopic nodes and ducts inside lymphatics and on the surface of internal organs are rich in granulocytes and secretory granulesByoung S Kwon
Cancer Biology and Immunotherapy, National Cancer Center, Ilsan, Kyunggi Do, Republic of Korea
Cytokine 60:587-92. 2012..Our results reveal a potential circulatory system whose anatomical structure and cellular content differ from the blood and lymph systems, and which may be involved in the transport of secretory granules...
- Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human bloodChantal Fradin
Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
Mol Microbiol 56:397-415. 2005..However, C. albicans is equipped with several genes and transcriptional programmes, which may help the fungus to counteract the attack of neutrophils, to escape from the bloodstream and to cause systemic infections...
- Neutrophil granulocytes as host cells and transport vehicles for intracellular pathogens: apoptosis as infection-promoting factorTamas Laskay
Institute of Medical Microbiology and Hygiene, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
Immunobiology 213:183-91. 2008Polymorphonuclear neutrophil granulocytes (PMN) are primary antimicrobial effector cells of the innate immune system and serve to destroy invading pathogens...
- The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytesG H Gudmundsson
Department of Microbiology, Stockholm University, Sweden
Eur J Biochem 238:325-32. 1996..Anti-(FA-LL-37) IgG located the peptide in granulocytes and we isolated the mature peptide from these cells after degranulation...
- C/EBPbeta is required for 'emergency' granulopoiesisHideyo Hirai
Harvard Institutes of Medicine and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA
Nat Immunol 7:732-9. 2006..Here we show that large numbers of granulocytes were generated from C/EBPalpha-deficient progenitors after cytokine stimulation in vivo...
- MicroRNA-27 enhances differentiation of myeloblasts into granulocytes by post-transcriptionally downregulating Runx1Jue Feng
Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
Br J Haematol 145:412-23. 2009..factor Runx1 by microRNA (miR)-27 and the resulting effects upon the differentiation of myeloblasts into granulocytes. When 32D...
- Differential particulate air pollution induced oxidant stress in human granulocytes, monocytes and alveolar macrophagesS Becker
US EPA, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
Toxicol In Vitro 16:209-18. 2002..Therefore, the inflamed lung is likely to be more susceptible to harm of ambient air particulates because of the oxidant stress posed by a broader range of particles...
- Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemiaT Pabst
Hematology Oncology Division, Harvard Institutes of Medicine, Harvard Medical School, Boston, Massachusetts, USA
Nat Genet 27:263-70. 2001..for CCAAT/enhancer binding protein-alpha; encoded by the gene CEBPA) is crucial for the differentiation of granulocytes. Conditional expression of C/EBPalpha triggers neutrophilic differentiation, and no mature granulocytes are ..
- E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivoB T Porse
Laboratory of Gene Therapy Research, 2100 Copenhagen Ø, Denmark
Cell 107:247-58. 2001The C/EBPalpha transcription factor is required for differentiation of adipocytes and neutrophil granulocytes, and controls cellular proliferation in vivo...
- Tumor-derived G-CSF facilitates neoplastic growth through a granulocytic myeloid-derived suppressor cell-dependent mechanismJeremy D Waight
Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, United States of America
PLoS ONE 6:e27690. 2011..This is complicated further by the fact that MDSC comprise multiple myeloid cell types, namely monocytes and granulocytes, reflecting diverse stages of differentiation and the proportion of these subpopulations vary among different ..
- Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophagesN Faust
Albert Einstein College of Medicine, Bronx, NY 10461, USA
Blood 96:719-26. 2000..and bone marrow of the lys-EGFP mice revealed that most myelomonocytic cells, especially mature neutrophil granulocytes, were fluorescence-positive, while cells from other lineages were not...
- c-Myc is a critical target for c/EBPalpha in granulopoiesisL M Johansen
Harvard Institutes of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell Biol 21:3789-806. 2001..This is the first report to demonstrate that C/EBPalpha directly affects the level of c-Myc expression and, thus, the decision of myeloid blasts to enter into the granulocytic differentiation pathway...
- PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitorsR P DeKoter
Department of Molecular Genetics and Cell Biology, The University of Chicago, IL 60637, USA
EMBO J 17:4456-68. 1998..It functions exclusively in a cell-intrinsic manner to control the development of granulocytes, macrophages, and B and T lymphocytes. We demonstrate that mutation of the PU...
- Proline-rich domain of penaeidin molecule exhibits autocrine feature by attracting penaeidin-positive granulocytes toward the wound-induced inflammatory siteChing Yu Li
Institute of Zoology, National Taiwan University, Taipei, Taiwan, ROC
Fish Shellfish Immunol 29:1044-52. 2010..Penaeidins are shrimp-specific AMPs that are synthesized and stored in granulocytes and released after stimulation...
- STAT3 controls myeloid progenitor growth during emergency granulopoiesisHuiyuan Zhang
Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 1903, USA
Blood 116:2462-71. 2010..These results place STAT3 as an essential mediator of emergency granulopoiesis by its regulation of transcription factors that direct G-CSF-responsive myeloid progenitor expansion...
- Prosthesis infection: diagnosis after total joint arthroplasty with antigranulocyte scintigraphy with 99mTc-labeled monoclonal antibodies--a meta-analysisEmilios E Pakos
Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, University Campus, Ioannina, 45110, Greece
Radiology 242:101-8. 2007..To perform a meta-analysis of diagnostic studies regarding the accuracy of antigranulocyte scintigraphy (AGS) with monoclonal antibodies in the identification of prosthesis infection after total hip or knee arthroplasty...
- Restoration of C/EBPalpha expression in a BCR-ABL+ cell line induces terminal granulocytic differentiationSigal Tavor
Division of Hematology Oncology, Cedars Sinai Medical Center, School of Medicine, UCLA, Los Angeles, California 90048, USA
J Biol Chem 278:52651-9. 2003....
- Demonstration of low-regulatory CD25High+CD4+ and high-pro-inflammatory CD28-CD4+ T-Cell subsets in patients with ulcerative colitis: modified by selective granulocyte and monocyte adsorption apheresisYoko Yokoyama
Division of Lower Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
Dig Dis Sci 52:2725-31. 2007..Additional studies are warranted, since a low frequency of CD25(High+)CD4(+) (-) and a high frequency of CD28(-)CD4(+) (-) expressing T cells might be a predictor of clinical response to GMA...
- Spodoptera litura multicapsid nucleopolyhedrovirus inhibits Microplitis bicoloratus polydnavirus-induced host granulocytes apoptosisKaijun Luo
State Key Laboratory of Biocontrol and Institute of Entomology, Sun Yat Sen Zhongshan University, Guangzhou 510275, P R China
J Insect Physiol 52:795-806. 2006..Furthermore, in vitro, the percentages of apoptosis showed that SpltMNPV BV could inhibit MbPDV-induced granulocytes apoptosis...
- The reduced GM-CSF priming of ROS production in granulocytes from patients with myelodysplasia is associated with an impaired lipid raft formationGwenny M Fuhler
Division of Hematology, Department of Medicine, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
J Leukoc Biol 81:449-57. 2007....
- Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophilsZvi G Fridlender
Institute of Pulmonary Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
PLoS ONE 7:e31524. 2012..This study characterizes different populations of neutrophils related to cancer, pointing out the major differences between TAN and the other neutrophil populations...
- Characterization of a novel population of low-density granulocytes associated with disease severity in HIV-1 infectionThomas Cloke
Department of Medicine, Section of Immunology, Faculty of Medicine, Imperial College London, London, United Kingdom
PLoS ONE 7:e48939. 2012..show that the cells expressing arginase in peripheral blood mononuclear cells of HIV+ patients are low-density granulocytes (LDGs) and that whereas these cells have a similar morphology to normal-density granulocyte, they are ..
- Blocking Fcα receptor I on granulocytes prevents tissue damage induced by IgA autoantibodiesLydia P van der Steen
Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
J Immunol 189:1594-601. 2012..FcαRI) by IgA induces a chemotactic-driven positive-feedback migration loop, hereby amplifying recruitment of granulocytes to IgA deposits...
- Regulation of granulocyte and monocyte differentiation by CCAAT/enhancer binding protein alphaAlan D Friedman
Department of Pediatric Oncology, Johns Hopkins University, 1650 Orleans Street, Baltimore, MD 21231, USA
Blood Cells Mol Dis 31:338-41. 2003..1, C/EBPepsilon, and cell cycle arrest...
- A retrospective search for predictors of clinical response to selective granulocyte and monocyte apheresis in patients with ulcerative colitisYasuo Suzuki
Department of Internal Medicine, Sakura Hospital, Toho University, Chiba University School of Medicine, Tokyo, Japan
Dig Dis Sci 51:2031-8. 2006..which is filled with cellulose acetate beads as the column leukocytapheresis carriers; the carriers adsorb granulocytes, monocytes/macrophages, and a small fraction of lymphocytes (FcgammaR and complement receptors bearing ..
- A mathematical model for reconstitution of granulopoiesis after high dose chemotherapy with autologous stem cell transplantationIvar Østby
Department of Informatics, University of Oslo, 0316 Oslo, Norway
J Math Biol 47:101-36. 2003..equation (PDE) with feedback from a cytokine compartment on proliferation, maturation, and mobilization of granulocytes from bone marrow to blood...
- In patients with ulcerative colitis, adsorptive depletion of granulocytes and monocytes impacts mucosal level of neutrophils and clinically is most effective in steroid naïve patientsT Tanaka
Internal Medicine, Chugoku Rosai Hospital, Hirotagaya 1 5 1, Kure, Hiroshima 737 0193, Japan
Dig Liver Dis 40:731-6. 2008..by its very nature is exacerbated and perpetuated by inflammatory cytokines, which are released by peripheral granulocytes and monocytes as well...
- Molecular and functional characterization of Hv1 proton channel in human granulocytesGábor L Petheo
Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary
PLoS ONE 5:e14081. 2010..in several cell types, but the majority of the data was collected in phagocytes, especially in human granulocytes. The prevailing view about the role of I(Hv) in phagocytes is that it is an essential supporter of the intense ..
- Activation-induced cell death and total Akt content of granulocytes show a biphasic course after low-dose radiationU S Gaipl
Department of Radiation Oncology, University of Erlangen Nuremberg, D 91054, Erlangen, Germany
Autoimmunity 42:340-2. 2009..We investigated the effects of low-dose radiation on the activation-induced cell death of polymorph nuclear granulocytes (PMN). A biphasic appearance of cell death in irradiated PMN was observed, displaying a relative maximum at 0...
- Effects of organic and inorganic selenium supplementation on selenoenzyme activity in blood lymphocytes, granulocytes, platelets and erythrocytesK M Brown
Rowett Research Institute, Division of Micronutrient and Lipid Metabolism, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, U K
Clin Sci (Lond) 98:593-9. 2000..In contrast, GPx4 activity in granulocytes and platelets in the selenomethionine group increased gradually over the 28 days...
- Heterozygous PU.1 mutations are associated with acute myeloid leukemiaBeatrice U Mueller
Harvard Institutes of Medicine, Harvard Medical School, Boston, MA, USA
Blood 100:998-1007. 2002..1 target genes. This is the first report of mutations in the PU.1 gene in human neoplasia and suggests that disruption of PU.1 function contributes to the block in differentiation found in AML patients...
- Differential expression of Toll-like receptor 2 in human cellsT H Flo
Institute of Cancer Research and Molecular Biology, The Norwegian University of Science and Technology, Trondheim
J Leukoc Biol 69:474-81. 2001..In human blood, CD14+ monocytes expressed the highest level of TLR2 followed by CD15+ granulocytes, and CD19+ B-cells, CD3+ T-cells, and CD56+ NK cells did not express TLR2...
- Deimination of arginine residues in nucleophosmin/B23 and histones in HL-60 granulocytesTeruki Hagiwara
Graduate School of Integrated Science, Yokohama City University, 22 2, Seto, Kanazawa Ku, Yokohama, 236 0027, Japan
Biochem Biophys Res Commun 290:979-83. 2002..To find a target of PAD V, we incubated HL-60 granulocytes with the calcium ionophore A23187 and studied deiminated proteins by immunocytochemistry and immunoblotting ..
- Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutationsHanna S Radomska
Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02115, USA
J Exp Med 203:371-81. 2006....
- A randomized, double-blind, sham-controlled study of granulocyte/monocyte apheresis for active ulcerative colitisBruce E Sands
MGH Crohn s and Colitis Center and Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Gastroenterology 135:400-9. 2008Activated granulocytes and monocytes/macrophages are implicated in the pathogenesis of ulcerative colitis...
- "Emergency" granulopoiesis in G-CSF-deficient mice in response to Candida albicans infectionS Basu
Ludwig Institute for Cancer Research, Melbourne Tumor Biology Branch, PO Royal Melbourne Hospital, Victoria 3050, Australia
Blood 95:3725-33. 2000..Blood. 2000;95:3725-3733)..
- Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrowYoshihiro Ueda
Department of Immunology, Duke University, Durham, NC 27710, USA
J Exp Med 201:1771-80. 2005..We demonstrate that granulopoiesis and lymphopoiesis are coupled specifically in the bone marrow by development in a common niche and propose that the leukopoietic equilibrium is specified by limiting amounts of developmental resources...
- Transcriptional control of granulocyte and monocyte developmentA D Friedman
Division of Pediatric Oncology, Johns Hopkins University, Baltimore, MD 21231, USA
Oncogene 26:6816-28. 2007..NF-kappaB directly binds and cooperates with C/EBPbeta to induce the inflammatory response in mature myeloid cells and potentially also cooperates with C/EBPalpha to regulate early myelopoiesis...
- Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responsesIan Sabroe
Section of Functional Genomics, Division of Genomic Medicine, University of Sheffield, Sheffield, United Kingdom
J Immunol 168:4701-10. 2002..We conclude that LPS has little role in the regulation of peripheral blood eosinophil and basophil function, and that, even in neutrophils, monocytes orchestrate many previously observed leukocyte LPS response patterns...
- Selective granulocyte and monocyte adsorptive apheresis as a first-line treatment for steroid naïve patients with active ulcerative colitis: a prospective uncontrolled studyYasuo Suzuki
Department of Internal Medicene, Sakura Hospital, Faculty of Medicine, Toho University, 564 1 Shimoshizu, Sakura City, Chiba 285 874, Japan
Dig Dis Sci 49:565-71. 2004..leukocytapheresis was done with Adacolumn, which contains cellulose acetate beads as adsorptive carriers for granulocytes and monocytes (FcgammaR and complement receptors expressing leukocytes)...
- Transcription activation function of C/EBPalpha is required for induction of granulocytic differentiationKaren Keeshan
Thomas Jefferson Medical College, Kimmel Cancer Institute, Philadelphia, PA 19107, USA
Blood 102:1267-75. 2003....
- Impact of urbanization on the proteome of birch pollen and its chemotactic activity on human granulocytesM Bryce
Division of Environmental Dermatology and Allergy, Helmholtz Center Munich TUM, ZAUM Center of Allergy and Environment, Technische Universitat, Munich, Germany
Int Arch Allergy Immunol 151:46-55. 2010..The allergenicity of birch pollen from both areas was evaluated by assessing its chemotactic potency as well as its protein and allergen contents...
- Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2Robert Girard
Lymphocyte Development, URA 1961 of the National Center for Scientific Research, Pasteur Institute, Paris, France
J Cell Sci 116:293-302. 2003..The data show selective action of different LPSs via different TLRs, and suggest that TLR2 can interact with many lipid A structures, leading to either agonistic or specific antagonistic effects...
- CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factorS Ergun
Department of Anatomy, University Hospital Eppendorf, Hamburg, Germany
Mol Cell 5:311-20. 2000..CEACAM1 purified from granulocytes and endothelial cell media as well as recombinant CEACAM1 expressed in HEK293 cells stimulate proliferation, ..
- Granulocyteaphaeresis in steroid-dependent inflammatory bowel disease: a prospective, open, pilot studyE Domenech
Hospital Universitari Germans Trias i Pujol, Badalona, Spain
Aliment Pharmacol Ther 20:1347-52. 2004..Uncontrolled studies suggest that granulocyteaphaeresis might be useful in the management of active ulcerative colitis...
- A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesisFrancesco Fazi
Department of Histology and Medical Embryology, University of Rome La Sapienza and San Raffaele Biomedical Science Park of Rome, Via di Castel Romano 100, 00128, Rome, Italy
Cell 123:819-31. 2005..Altogether, our data indicate that miR-223 plays a crucial role during granulopoiesis and point to the NFI-A repression as an important molecular pathway mediating gene reprogramming in this cell lineage...
- Increased respiratory burst and increased expression of complement receptor-3 (CD11b/CD18) and of IL-8 receptor-A in neutrophil granulocytes from newborns after vaginal deliveryPeter Gessler
Intensive Care and Neonatology, University Children s Hospital, Berne, Institute of Immunology, University of Berne, Switzerland
Biol Neonate 83:107-12. 2003..in cord blood as a function of the mode of delivery, we performed analysis of the function of neutrophil granulocytes by assessing their ability to produce reactive oxygen products (ROP) as well as neutrophil cell surface ..
- Granulocyte, monocyte/macrophage apheresis for inflammatory bowel disease: the first 100 patients treated in ScandinaviaTryggve Ljung
Department of Gastroentereology and Hepatology, Karolinska University Hospital, Stockholm, Sweden
Scand J Gastroenterol 42:221-7. 2007....
- Gadd45a and Gadd45b modulate innate immune functions of granulocytes and macrophages by differential regulation of p38 and JNK signalingDominic M Salerno
Fels Institute for Cancer Research and Molecular Biology, Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
J Cell Physiol 227:3613-20. 2012..This study shows that mice lacking either Gadd45a or Gadd45b are defective in the recruitment of granulocytes and macrophages to the intra-peritoneal cavity following intra-peritoneal administration of the bacterial cell ..
- Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemiaJinyong Wang
McArdle Laboratory for Cancer Research, University of Wisconsin Madison, Madison, WI 53706, USA
Blood 116:5991-6002. 2010..Our results provide insights into the aberrant cytokine signaling in oncogenic NRAS-associated myeloid diseases...
- Comparison of interferon-γ-, interleukin (IL)-17- and IL-22-expressing CD4 T cells, IL-22-expressing granulocytes and proinflammatory cytokines during latent and active tuberculosis infectionJ Cowan
Ottawa Hospital Research Institute, Ottawa, ON, Canada
Clin Exp Immunol 167:317-29. 2012..of interferon (IFN)-γ-, interleukin (IL)-17- and IL-22-expressing CD4(+) T cells and IL-22-expressing granulocytes in peripheral blood were significantly lower in latently infected healthy individuals and active tuberculosis ..
- Overexpression of TGF-beta by infiltrated granulocytes correlates with the expression of collagen mRNA in pancreatic cancerY Aoyagi
Pathology Division, National Cancer Center Research Institute East, Kashiwanoha 6 5 1, Kashiwa, Chiba 277 8577, Japan
Br J Cancer 91:1316-26. 2004..Moreover, the predominant cells that express TGF-beta were likely to be infiltrated granulocytes (mostly are neutrophils) and not pancreatic cancer cells.
- Long-term follow-up with Granulocyte and Monocyte Apheresis re-treatment in patients with chronically active inflammatory bowel diseaseAnnelie Lindberg
Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset SE 118 83 Stockholm, Sweden
BMC Gastroenterol 10:73. 2010....
- Regulation of the myeloperoxidase enhancer binding proteins Pu1, C-EBP alpha, -beta, and -delta during granulocyte-lineage specificationA M Ford
Leukaemia Research Fund Centre, Chester Beatty Laboratories, London, United Kingdom
Proc Natl Acad Sci U S A 93:10838-43. 1996....
- Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineageBo T Porse
Laboratory of Gene Therapy Research, Copenhagen University Hospital, 2100 Copenhagen, Denmark
J Exp Med 202:85-96. 2005..These results show that disrupting the cell cycle regulatory function of C/EBP alpha is sufficient to initiate AML-like transformation of the granulocytic lineage, but only partially the peripheral pathology of AML...
- Sialic acid binding immunoglobulin-like lectins may regulate innate immune responses by modulating the life span of granulocytesStephan von Gunten
Department of Pharmacology, University of Bern, Bern, Switzerland
FASEB J 20:601-5. 2006..Based on these recent insights, we hypothesize that at least some members of the Siglec family regulate immune responses via the activation of caspase-dependent and caspase-independent cell death pathways...
- Granulocyte transfusion: current statusThomas H Price
Puget Sound Blood Center and Department of Medicine, University of Washington, Seattle, WA 98104, USA
Semin Hematol 44:15-23. 2007..transfusion therapy as treatment for this condition has been generated by the observation that large doses of granulocytes can be obtained from donors who have been stimulated with granulocyte colony-stimulating factor (G-CSF)...
- Leukocytapheresis (LCAP) decreases the level of platelet-derived microparticles (MPs) and increases the level of granulocytes-derived MPs: a possible connection with the effect of LCAP on rheumatoid arthritisKunihiko Umekita
Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan
Mod Rheumatol 19:265-72. 2009..These data suggest that removal of platelet-derived MPs and increase of granulocyte-derived MPs are novel mechanisms of LCAP as effective treatment in RA...
- The flavonoid luteolin inhibits Fcγ-dependent respiratory burst in granulocytes, but not skin blistering in a new model of pemphigoid in adult miceEva Oswald
Allergy Research Group, Department of Dermatology, University Freiburg Medical Center, Freiburg, Germany
PLoS ONE 7:e31066. 2012..Luteolin inhibited the Fcγ-dependent respiratory burst in immune complex-stimulated granulocytes and the autoantibody-induced dermal-epidermal separation in skin cryosections, but was not effective in ..
- Effect of Biolex Beta-HP on phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes in rats intoxicated by cyclophosphamideR Wojcik
Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10 718 Olsztyn, Poland
Pol J Vet Sci 13:181-8. 2010..beta-1,3/1,6-D-glucan (Biolex-Beta HP) on the phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes in rats intoxicated by cyclophosphamide...
- The CD16- CD56(bright) NK cell subset is resistant to reactive oxygen species produced by activated granulocytes and has higher antioxidative capacity than the CD16+ CD56(dim) subsetHelena Harlin
Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden
J Immunol 179:4513-9. 2007..We show that the CD16+ CD56(dim) NK subset is characterized by sensitivity to cell death induced by activated granulocytes. We identified hydrogen peroxide (H2O2) as the major effector molecule responsible for the cytotoxic effect of ..
- Adacolumn, an adsorptive carrier based granulocyte and monocyte apheresis device for the treatment of inflammatory and refractory diseases associated with leukocytesAbby R Saniabadi
Japan Immunoresearch Laboratories, Takasaki, Japan
Ther Apher Dial 7:48-59. 2003..Pre- and post-column leukocyte counts have shown that the carriers adsorb about 65% of granulocytes, 55% of monocytes and 2% of lymphocytes from the blood in the column...
- Immunophenotyping and characterization of BNP colostra revealed pathogenic alloantibodies of IgG1 subclass with specifity to platelets, granulocytes and monocytes of all maturation stagesAryan Assad
Clinic for Ruminants, Centre of Clinical Veterinary Medicine, Ludwig Maximilians University, Sonnenstraße 16, D 85764 Oberschleißheim, Germany
Vet Immunol Immunopathol 147:25-34. 2012..on platelets as well as leukocyte subsets by BNP-IgG1 alloantibody exposed 100% reactivity to platelets, granulocytes and monocytes. Interestingly, the main part of T-helper cells was not bound by colostral alloantibodies...
- Reversible control by vitamin D of granulocytes and bacteria in the lungs of mice: an ovalbumin-induced model of allergic airway diseaseShelley Gorman
Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia
PLoS ONE 8:e67823. 2013....
- C/EBPα regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutationsJohn A Pulikkan
Department of Internal Medicine IV Oncology and Hematology, Martin Luther University Halle Wittenberg, Halle, Germany
Blood 116:5638-49. 2010..Manipulation of miR-34a reprograms granulocytic differentiation of AML blast cells with CEBPA mutations. These results define miR-34a as a novel therapeutic target in AML with CEBPA mutations...
- C/EBPalpha S248A mutation reduces granulocytic differentiation in human leukemic K562 cellsSheo M Singh
Bone Marrow Transplantation Section, State Center for Cell and Gene Therapy, Department of Internal Medicine IV, Martin Luther University, Ernst Grube Str 40, Halle 06097, Germany
Biochem Biophys Res Commun 369:692-4. 2008..Based on our observations in the present study, we conclude that S248A mutation of C/EBPalpha leads to a reduction of granulocytic differentiation markers and a block in differentiation at the morphological level...
- Mucosal healing in patients with ulcerative colitis during a course of selective leukocytapheresis therapy: a prospective cohort studyTakayuki Yamamoto
Inflammatory Bowel Disease Center, Yokkaichi Social Insurance Hospital, Yokkaichi, Mie, Japan
Inflamm Bowel Dis 16:1905-11. 2010During active ulcerative colitis (UC), vast numbers of granulocytes, monocytes/macrophages (GM) infiltrate the mucosal tissue and can potentially exacerbate inflammation and injury...
- Ras signaling enhances the activity of C/EBP alpha to induce granulocytic differentiation by phosphorylation of serine 248Gerhard Behre
Department of Internal Medicine III, University Hospital Grosshadern, Ludwig Maximilians University Munich and GSF National Research Center for Environment and Health, D 81377 Munich, Germany
J Biol Chem 277:26293-9. 2002..These data suggest a model where Ras signaling enhances the activity of C/EBP alpha to induce granulocytic differentiation by phosphorylation of serine 248...
- Target proteins of C/EBPalphap30 in AML: C/EBPalphap30 enhances sumoylation of C/EBPalphap42 via up-regulation of Ubc9Mulu Geletu
Bone Marrow Transplantation Section, State Center for Cell and Gene Therapy, Department of Internal Medicine IV Hematology Oncology, University Hospital of Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, 06120 Halle, Germany
Blood 110:3301-9. 2007..In summary, our data indicate that Ubc9 is an important C/EBPalphap30 target through which C/EBPalphap30 enhances the sumoylation of C/EBPalphap42 to inhibit granulocytic differentiation...
- Crawling phagocytes recruited in the brain vasculature after pertussis toxin exposure through IL6, ICAM1 and ITGαMJean François Richard
Department of Endocrinology and Genomics, Laval University Hospital Research Center, Quebec City, Quebec, Canada
Brain Pathol 21:661-71. 2011..Here, we report that the population of crawling leukocytes, consisting mainly of granulocytes, is also increased in the brains of mice suffering from experimental autoimmune encephalomyelitis (EAE) or ..
- Automated enumeration of immature granulocytesBernard Fernandes
Department of Laboratory Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Canada
Am J Clin Pathol 128:454-63. 2007..The results also confirm that the flow cytometric IG count is superior to and can replace the manual morphology count as a reference method for IG counting...
- Binding of avian IgY to type VII collagen does not activate complement and leucocytes and fails to induce subepidermal blistering in miceA Sesarman
Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
Br J Dermatol 158:463-71. 2008....
- Apoptotic human cells inhibit migration of granulocytes via release of lactoferrinIrini Bournazou
The University of Edinburgh Medical Research Council MRC Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, UK
J Clin Invest 119:20-32. 2009..How apoptotic cells attract mononuclear phagocytes and not granulocytes, the professional phagocytes that accumulate at sites of inflammation, has not been determined...
- Characterisation of gilthead seabream acidophilic granulocytes by a monoclonal antibody unequivocally points to their involvement in fish phagocytic responseM P Sepulcre
Department of Cell Biology, Faculty of Biology, University of Murcia, Campus Universitario de Espinardo 30100 Murcia, Spain
Cell Tissue Res 308:97-102. 2002..and characterisation of a monoclonal antibody, G7, which specifically recognises gilthead seabream acidophilic granulocytes, as assayed by immunofluorescence and immunoelectron microscopy...
- Telomere length measurements in leukocyte subsets by automated multicolor flow-FISHGabriela M Baerlocher
Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada
Cytometry A 55:1-6. 2003..Here we report improvements in flow-FISH methodology that enable measurements of telomere length in subsets of human nucleated blood cells...
- The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory painElisa Giannini
Department of Physiology and Pharmacology Vittorio Erspamer, Sapienza University of Rome, I 00185 Rome, Italy
Proc Natl Acad Sci U S A 106:14646-51. 2009..Such an increase in PK2 mRNA depends mainly on a marked up-regulation of PK2 gene transcription in granulocytes. A substantially lower up-regulation was also detected in macrophages...
- Phosphorylation of C/EBPalpha inhibits granulopoiesisSarah E Ross
Department of Molecular and Integrative Physiology, University of Michigan Medical School, 1301 E Catherine Street, Ann Arbor, MI 48109 0622, USA
Mol Cell Biol 24:675-86. 2004..factors that mediate lineage specification and differentiation of multipotent myeloid progenitors into mature granulocytes. Although C/EBPalpha is known to induce granulopoiesis while suppressing monocyte differentiation, it is ..
- Chronic myeloid leukemia with increased granulocyte progenitors in mice lacking junB expression in the myeloid lineageE Passegue
Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Cell 104:21-32. 2001..These results identify JunB as a key transcriptional regulator of myelopoiesis and a potential tumor suppressor gene...
- CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IVF Nakayama
Division of Cell Biology, Institute of Life Science, Soka University, Tokyo 192 8577, Japan
J Biol Chem 276:16100-6. 2001..competitive reverse transcriptase-polymerase chain reaction, FUT9 was found to be strongly expressed in mature granulocytes and peripheral blood mononuclear cell, but not in monocytes...
- Enhanced survival of lung granulocytes in an animal model of asthma: evidence for a role of GM-CSF activated STAT5 signalling pathwayR K Turlej
Department of Physiology, Faculty of Veterinary Medicine, , , Belgium
Thorax 56:696-702. 2001..METHODS: Blood granulocytes were recovered from six healthy and six heaves affected horses, a model of asthma...
- Interleukin-18 stimulates hematopoietic cytokine and growth factor formation and augments circulating granulocytes in miceT Ogura
Biochemistry II group, Research Department, Sawai Pharmaceutical, Osaka, Japan
Blood 98:2101-7. 2001....
- Safety and efficacy of granulocyte and monocyte adsorption apheresis in patients with active ulcerative colitis: a multicenter studyT Shimoyama
Department of Internal Medicine IV, Hyogo College of Medicine, Hyogo, Japan
J Clin Apher 16:1-9. 2001Active ulcerative colitis (UC) is characterized by activation and infiltration of granulocytes and monocytes/macrophages into the colonic mucosa...
- Increase of reactive oxygen (ROS) and nitrogen (RNS) species generated by phagocyting granulocytes related to ageM Martins Chaves
Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av Antônio Carlos 6627 CP 486, 30161 970, Minas Gerais, Belo Horizonte, Brazil
Mech Ageing Dev 119:1-8. 2000..on reactive oxidizing species generated by oxygen (ROS) and nitrogen (RNS) was studied using human phagocyting granulocytes. The ROS and RNS were quantified, respectively, in a chemiluminescence assay and by the measurement of nitrite ..
- Differential expression of toll-like receptor 6 on granulocytes and monocytes implicates the role of microorganisms in Behcet's disease etiopathogenesisSule Yavuz
Department of Rheumatology, University of Marmara, Istanbul, Turkey
Rheumatol Int 28:401-6. 2008..Results were confirmed using semi-quantitative PCR technique. The mean frequency of TLR-6 expressing granulocytes in BD patients was significantly lower than in controls (4.2 +/- 0.6 vs. 9.2 +/- 0.6 and 8.0 +/- 1.4, BD vs...
- Influence of polysaccharides from Viscum album L. on human lymphocytes, monocytes and granulocytes in vitroG M Stein
Krebsforschung Herdecke, Department of Applied Immunology, University Witten Herdecke, Communal Hospital, Germany
Anticancer Res 19:3907-14. 1999..An acidic arabinogalactan from European mistletoe (Viscum album L, VAL; 1.34 x 10(6) Dalton) was studied in detail because its immunological properties are poorly characterised...
- Expression of C/EBPbeta from the C/ebpalpha gene locus is sufficient for normal hematopoiesis in vivoLetetia C Jones
Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, 8700 Beverly Blvd, Rm 109, Los Angeles, CA 90048, USA
Blood 99:2032-6. 2002..These results imply that C/EBPbeta can substitute for C/EBPalpha during hematopoiesis when expressed from the C/ebpalpha gene locus...
- Optimization of Neoglycoside Antibiotics for Nosocomial Pathogens and Select AgenArnold Louie; Fiscal Year: 2013..We will apply another completely novel model to all data, to understand pathogen kill by granulocytes. We will validate exposure targets from SA #1 with an understanding of the granulocyte impact...
- Mechanisms Regulating Reduced c-Kit-Dependent EAE Susceptibility in Male SJL MiceMELISSA ANN BROWN; Fiscal Year: 2013..Mast cells are granulocytes that reside in most tissues and are among the innate cells that exert an important amplifying effect on disease ..
- Eosinophil ORMDL3 and allergic inflammationP Sriramarao; Fiscal Year: 2012..Eosinophils (Eos) are one of the most proinflammatory granulocytes that contribute to the pathogenesis and exacerbation of the disease...
- Organismal Radioprotection Through Pharmacological QuiescenceJOHN S CHANT; Fiscal Year: 2010..affords radioprotection, enhancing survival and protecting all blood lineages including red cells, platelets, granulocytes and lymphocytes. G-Zero has licensed broad intellectual property surrounding the use of PQ for radioprotection...
- Lung and bone marrow crosstalk during a respiratory infectionCAROLINA B LOPEZ; Fiscal Year: 2010..Information regarding the contribution of monocytes, granulocytes, and other non-antigen specific cells recruited from the BM for lung immunity is also lacking...
- THE FUNCTION AND REGULATION OF HISTIDINE DECARBOXYLASE IN GUT INFLAMMATIONTIMOTHY CRAGIN WANG; Fiscal Year: 2013..aims: (1) Are HDC-expressing CD11b+Gr1+ cells myeloid precursors that give rise to mature monocytes and granulocytes and other cell types? We will utilize HDC-BAC-Cre-ERTM mice developed in our laboratory to trace the ..
- Purification &Characterization of Adenosine ReceptorsJoel M Linden; Fiscal Year: 2009..Aim 1 is to create tissue specific deletions n granulocytes, T cells, cardiomyocytes, endothelial cells and hepatocytes of the A^AR gene through the useiof the Cre/lox ..
- Genomic Instability in Ageing and CancerDavid J Araten; Fiscal Year: 2013..By this approach, we have been able to measure f in granulocytes, and both [unreadable] and f in B lymphoblastoid cell lines and expanding cultures of ex vivo T lymphocytes ..
- Oncolytic Viruses with Therapeutic Genes in the Treatment of Breast CancerDANUTA B KOZBOR; Fiscal Year: 2013..regulatory factor-8 (IRF8), a putative determinant of protumorigenic behavior of MDSCs, in tumor-infiltrating granulocytes, ii) reduced percentage of FAP+ cancer associated fibroblasts (CAFs), iii) decreased levels of CXCL12, and iv) ..
- ENDOSTEAL BONE VOLUME REGULATION AND OSTEOPOROSISSubburaman Mohan; Fiscal Year: 2013..Cldn-18 action on OCs, we will determine if Cldn-18 influences the differentiation of progenitors into mature granulocytes and macrophages...
- Instant Pediatric POC Blood AnalysisNEVEN KARLOVAC; Fiscal Year: 2012..2) Research imaging of WBC 3-part differential (granulocytes, monocytes, and lymphocytes) with a holographic LUCAS imager and demonstrate accurate counting;(3) Develop a ..
- Myeloid Lineage Differentiation and Osteoclast Priming by a Novel Pax5 CytokineMark C Horowitz; Fiscal Year: 2013..It is now well accepted that osteoclasts, like macrophages, granulocytes and dendritic cells, are members of the myeloid lineage arising from hematopoietic stem cells...
- Development of GZ38-1, a Novel Protectant of Chemotherapy-Induced MyelosuppressioJAY COPELAND STRUM; Fiscal Year: 2013..that the PQ approach can significantly protect all hematopoietic cell lineages (including red cells, platelets, granulocytes and lymphocytes) from chemotherapy-induced DNA damage...
- Activated Targeted Killer (ATAK) Cells for Invasive Fungal InfectionsBrad J Spellberg; Fiscal Year: 2013..the efficiency with which they kill Candida albicans, consistent with the cells'maturation towards mature granulocytes. Administration of ATAK cells substantively improves the survival of neutropenic mice infected with C...
- Correction of myeloid cell defects in cancerDmitry I Gabrilovich; Fiscal Year: 2013..pathway of differentiation to mature myeloid cells (dendritic cells (DC), macrophages (M[unreadable]), and granulocytes) towards differentiation of pathological MDSCs...
- Aquaporin-4 in NMO Optic Neuritis: Pathogenesis and New TherapiesAlan S Verkman; Fiscal Year: 2013..The role of granulocytes, macrophages and NK cells will be investigated, with the goal of defining new therapeutic targets...
- Vesicular trafficking mechanisms regulating granulocyte functionSERGIO DANIEL CATZ; Fiscal Year: 2013..pioneered the development of systems biology approaches to analyze vesicular dynamics and actin remodeling in granulocytes. In this application, we propose to use innovative analytical and quantitative methods to elucidate the ..
- The role of glucocorticoid signaling in immune cells during excitotoxicity.SHAWN SORRELLS; Fiscal Year: 2010..However, chronic GC exposure was recently found to increase CMS infiltration of macrophages, granulocytes, and microglia to excitotoxic injury accompanied by elevated levels of the pro-inflammatory cytokines IL-1(i, ..
- NETs in the development of lupus and its cardiovascular complicationsDaniel T Eitzman; Fiscal Year: 2013..The association of neutrophil:platelet aggregates (NPAs), low-density granulocytes (LDGs), NETosis and autoAbs to neutrophil-derived immunostimulatory products, with endothelial dysfunction, ..
- HSC Diversity: Regulation by Clonal Selection vs Epigenetic InductionIrving L Weissman; Fiscal Year: 2013..We will test whether the end blood cell types [RBC, platelets, granulocytes, monocytes and macrophages, the various lymphocytes] when lacking or transfused in overabundance bring ..
- MOLECULAR ASPECTS OF LEUKOCYTE ANTIMICROBIAL PEPTIDESMichael E Selsted; Fiscal Year: 2013..effects of ?-defensins will be analyzed by quantifying peptide biosynthesis/secretion by stimulated macaque granulocytes and determining the immunomodulatory effects of releasates on resting and activated target cells;analogous ..
- Lineage-Specific Roles for the Ron Receptor in Prostate CancerANDREW PALUCH; Fiscal Year: 2013..Our preliminary data suggests that Ron signaling in myeloid cells (macrophages and granulocytes) is crucial to maintaining a pro-tumorigenic microenvironment and consequently, to tumor establishment in an ..
- Converting an Oncogene to an Apoptotic Factor by Manipulating Signal SequencesCarol S Lim; Fiscal Year: 2012..CML is a myeloproliferative disorder characterized by increased proliferation of granulocytes and their immature precursors;with a median survival time of 4 to 6 years...
- KLF4, myeloid development, and transplantation arteriosclerosisA K M KHYRUL WARA; Fiscal Year: 2010..bone marrow cells, KLF4 is absent in common myeloid progenitors but highly expressed in monocytes but not granulocytes. Retroviral overexpression of KLF4 alone in the human promyelocytic cell line, HL-60, confers the morphologic, ..
- Basophils in Modulating Th2 Responses in Human Allergic DiseaseJohn T Schroeder; Fiscal Year: 2011..In humans, these rare granulocytes release inflammatory mediators (histamine and LTC4) and cytokines (IL-4 and IL-13) central in the pathogenesis ..
- Studies of Paired Immunoglobulin-Like ReceptorsHiromi Kubagawa; Fiscal Year: 2010..PIR-B are expressed by many hematopoietic cell types, including B cells, monocyte/macrophages, dendritic ceils, granulocytes, mast cells, and megakaryocyte/platelets, but not by T and NK cells...
- Role of Mucin-type O-glycans in Intestinal InflammationLijun Xia; Fiscal Year: 2013..immunity, manifested similarly severe colitis, suggesting an essential role for innate immune cells such as granulocytes in colitis development...
- The inflammatory role of the platelet in aspirin-exacerbated respiratory disease.TANYA MARIA LAIDLAW; Fiscal Year: 2013..the threshold for activation of their platelets and allows for increased platelet adhesion onto inflammatory granulocytes and monocytes...
- Measurement of physiological secretory vesicle-plasma membrane tethering forces oManfred Lindau; Fiscal Year: 2011..as well as many other compounds including histamine from mast cells or cytotoxic proteins from eosinophilic granulocytes. The readily releasable vesicles of neurons and neuroendocrine cells are awaiting stimulation in a state ..
- Alcohol and Sca-1;Impairment of the granulopoietic precursor cell responseJohn Nicholas Melvan; Fiscal Year: 2013..Representing the largest population of phagocytes in the systemic circulation, granulocytes constitute the first line of host defense against invading pathogens...
- The Functional of TREM-1 in SepsisMarco Colonna; Fiscal Year: 2010..In our preliminary experiments we have established a system that detects a ligand on the surface of granulocytes of septic patients and have identified a monoclonal antibody that recognizes the TREM-1 ligand or a component ..
- Anemia in the Elderly: PathogenesisJeffrey S Friedman; Fiscal Year: 2010..With circulating granulocytes serving as surrogates for EPC we will examine mtDNA and telomere length and G loop structure...
- immunopathogenesis of NMO-IgG and AQP4-specific T cells in neuromyelitis opticaMichael Levy; Fiscal Year: 2013..Characterizing the role of the NMO-IgG in inducing or exacerbating the NMO disease phenotype by recruiting granulocytes, 2...
- The role of Th17 cytokines in H.pylori infectionHOLLY MARIE SCOTT ALGOOD; Fiscal Year: 2013..but since the receptor for IL-17, IL-17RA, is expressed on many cell types, including epithelial cells, granulocytes, and lymphocytes, its effects are even more widespread...
- ISG15 responsive pathwayDusan Bogunovic; Fiscal Year: 2013..Its conjugation to various proteins (ISGylation) contributes to antiviral immunity in mice I identified granulocytes as a major source of secreted free ISG15, stimulating the production of IFN-? by lymphocytes, including NK ..
- Single Cell Diagnosis of Leukemia using Multiplex Nested PCR SystemWINSTON Z HO; Fiscal Year: 2010..myelogenous (or myeloid) leukemia (CML) detection are based on the complete blood count, which shows increased granulocytes of all types...
- DIFFERENTIATION OF GRANULOCYTES AND MACROPHAGESDonald Metcalf; Fiscal Year: 2013..RELEVANCE (See instructions): Successful outcomes will provide new strategies for intervention in cytokine-related diseases, particularly cancer and inflammation. ..
- Mechanisms of Human Basophil-Mediated Allergic InflammationDavid P Huston; Fiscal Year: 2012..Basophils are the least abundant granulocytes in the circulation, and only recently has evidence demonstrated that basophils have potent effector functions ..
- AsthmaNet: UW-Madison Clinical and Translational Research CenterCHRISTINE ANNE SORKNESS; Fiscal Year: 2013..eosinophilic and neutrophilic inflammation and will determine if the phenotypic profile of sputum inflammatory granulocytes predicts response to the treatment...
- Eosinophil-nerve Interactions in Mouse Models of DermatitisJAMES JOSEPH LEE; Fiscal Year: 2013..skin inflammation is noted in the available mouse models of dermatitis, suggesting an underlying role for these granulocytes. Unfortunately, despite the strong correlative relationship, the definition of eosinophil-mediated events ..
- Structure-Activity Relationship of CM101 Tumor antiangiogenic agent with its lectBETTY CHOURONG ZHU; Fiscal Year: 2012..CM101 binds a capillary endothelium receptor, HP59, causing inflammatory cytokine cascades, recruiting CD69+ granulocytes to destroy neovasculature and surrounding tumor...
- JAK-3 AND MYELOID CELL DIFFERENTIATIONE Reddy; Fiscal Year: 2000..The aims include: 1) to extend previous studies with 32Dcl3 cells (capable of differentiating only to granulocytes) to the M1 cell line (capable of monocytic differentiation in response to IL6); since JAK kinases are known to ..
- Transfusion Medicine/Hemostasis Clinical Research NetworkRonald G Strauss; Fiscal Year: 2012..transfusion medicine and hematology to potentially explore the role for other blood derived products, such as granulocytes. Three research studies have been approved by the Protocol Review Committee and DSMB (PLADO, SHIP and RICH) and ..
- Role of Natural Killer Cells in Myocarditis and Dilated CardiomyopathySufey Ong; Fiscal Year: 2013..This suggests that NK cells can directly interact with both members of the adaptive immune system and granulocytes. This proposal seeks to elucidate the mechanisms by which NKs modulate T cell responses in vivo and in vitro by ..
- OXYGEN RADICAL-ENZYME SCAVENGING IN ONCHOCERCAEric James; Fiscal Year: 1990..in infections with Trichinella spiralis, is the enzymatic degradation of free radicals generated by phagocytes/granulocytes. This study will look at the presence of superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-..
- Apoptosis in myelofibrosis with myeloid metaplasiaRuben Mesa; Fiscal Year: 2006..shown that apoptosis (spontaneous, serum deprivation, and TNF-alpha induced) is quantitively diminished in the granulocytes of patients with MMM...
- A TRANSCRIPTIONAL PROGRAM REGULATING MYELOPOIESISAlan Friedman; Fiscal Year: 2004..C/EBPalpha (C/EBPa) and PU.1 are key regulators of myelopoiesis. C/EBPa null mice lack granulocytes, and PU.1 null mice lack B cells, granulocytes, and monocytes...
- GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AGYasuko Rikihisa; Fiscal Year: 2004..HGE is caused by infection of peripheral blood granulocytes with an obligate intracellular bacterium, an ehrlichia sp. called an HGE agent...
- METABOLIC ACTIVATION OF ARYLAMINES IN LEUKOCYTESMichael Corbett; Fiscal Year: 1991..The potential for phagocytic leukocytes (granulocytes, monocytes and macrophages) to cause damage to surrounding cells is already known to result from the release of ..
- Genetic Basis of Myeloid Neoplasia--Mutagenesis ScreensA Look; Fiscal Year: 2005..to identify dominant and recessive mutations that cause a deficiency or abnormal distribution of circulating granulocytes, implicating genes important in vertebrate myelopoiesis; and (Ii) a subset of the genes discovered by this ..
- ROLE OF T LYMPHOCYTE FACTORS IN HEMOPOIESIS 0Michael Prystowsky; Fiscal Year: 1992..The first cells to arrive at a site of inflammation are neutrophilic granulocytes; macrophages usually appear several hours after granulocytes...
- GLYCOLIPID E-SELECTIN LIGANDS ON HUMAN GRANULOCYTESBruce Bochner; Fiscal Year: 2003..Adhesion molecules and complementary ligands on granulocytes and on the blood vessel wall endothelium control the extent and identity of granulocytes entering the tissue at ..
- PATHOGENESIS OF HUMAN GRANULOCYTIC EHRLICHIOSISUlrike Munderloh; Fiscal Year: 2001..HGE appears in blood granulocytes, causes depression of leukocyte and platelet counts, and can result in serious complications...
- LEUKEMIA THERAPY AND NEUTROPHIL DYSFUNCTIONPHILIP CRADDOCK; Fiscal Year: 1980During the next four years, I plan to continue my studies of the interactions between circulating granulocytes, the plasma complement system and the vascular endothelium...
- MOLECULAR MECHANISMS OF TUMOR NECROSIS FACTORDavid Spriggs; Fiscal Year: 1991..TNF is a potent activator of granulocytes, monocytes, and eosinophils. This agent is also a direct mediator of macrophage cytotoxicity...
- HUMORAL FACTORS IN INFLAMMATIONTONY HUGLI; Fiscal Year: 1993..spasmogenic, chemotactic and immunoregulatory responses primarily through specific receptor interactions with granulocytes and monocytes...
- WHITE BLOOD CELL OXIDASE IN LEUKEMIA AND NORMAL CELLSPeter Newburger; Fiscal Year: 1991..III. Examination of X-CGD gene expression in granulocytes and macrophages treated with cytokines that modulate superoxide production...
- BIOCHEMICAL EVALUATION OF F INTERACTIONS IN GRANULOCYTESBRIDGET BYRNE; Fiscal Year: 1990..to studies in the functional and biochemical evaluation of the mechanisms involved in F- induced changes in granulocytes (e.g...
- Tyrosine Phosphatase PTP-MEG2 and HematopoiesisZHIZHUANG ZHAO; Fiscal Year: 2009..Polycythemia vera (PV) is a clonal hematologic disease characterized by excessive production of red cells, granulocytes, and platelets in blood...
- Innate Immune Response Genes and P. GingivalisJenny Ting; Fiscal Year: 2009..tissue injury caused by the response of cells of the innate immune system, namely monocytes/macrophages and granulocytes. In recent years, the Toll-like receptors (TLR) have rapidly emerged as a dominant route by which the innate ..
- NITRIC OXIDE SIGNALING IN ALLERGIC AIRWAY DISEASEAlbert van Der Vliet; Fiscal Year: 2007..Since inflammatory conditions involve recruitment of granulocytes and activation of oxidant-producing enzymes, such as eosinophil peroxidase (EPO), metabolism of NO" is likely ..
- The role of cytomegalovirus antiapoptotic proteins in replication in macrophages.ANITA LOUISE MCCORMICK; Fiscal Year: 2010..from them are highly likely target cells for this manipulation based on the following: 1) progenitors of granulocytes, macrophages, and dendritic cells (GM-Ps) are important contributors to HCMV transmission because they harbor ..
- MECHANISMS OF RHINOVIRUS INDUCED ASTHMAWilliam Busse; Fiscal Year: 2002..through the coordinated interaction of RV-infected pulmonary epithelium, with endothelium and infiltrating granulocytes. To cause these effects, we propose that RV infection of airway epithelial cells first induces secretion of ..
- Towards In Vivo Force Spectroscopy Using Optomagnetic TweezersRobert L Clark; Fiscal Year: 2013..Initially probes will be inserted into live granulocytes to access instrument performance...
- CHARACTERIZATION OF BONE MARROW DERIVED GRANULOCYTESJames Bender; Fiscal Year: 1991Maturation of granulocytes (i.e. neutrophils) from stem cells is believed to be directed by specific factors which control proliferation and differentiation...
- Action of Interferon in Chronic Myelogenous LeukemiaLeonidas Platanias; Fiscal Year: 2005..Our data demonstrate that this signaling cascade is activated in primary granulocytes from CML patients and that pharmacological blockade of its activation reverses the growth inhibitory effects of ..
- DISCORDANT XENOGRAFTINGFRITZ BACH; Fiscal Year: 1993..of endothelial activation: extravasation of cells into the extravascular space, edema, deposition of granulocytes and platelets on the endothelium and thrombosis...