bone marrow cells

Summary

Summary: Cells contained in the bone marrow including fat cells (see ADIPOCYTES), STROMAL CELLS, MEGAKARYOCYTES, and the immediate precursors of most blood cells.

Top Publications

  1. ncbi Multilineage potential of adult human mesenchymal stem cells
    M F Pittenger
    Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231 3043, USA
    Science 284:143-7. 1999
  2. ncbi Marrow stromal cells as stem cells for nonhematopoietic tissues
    D J Prockop
    Center for Gene Therapy, Allegheny University of the Health Sciences, MCP Hahnemann School of Medicine, 245 North 15 Street, Mail Stop 421, Philadelphia, PA 19102, USA
    Science 276:71-4. 1997
  3. ncbi Pluripotency of mesenchymal stem cells derived from adult marrow
    Yuehua Jiang
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 418:41-9. 2002
  4. ncbi Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue
    Susanne Kern
    Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden Württemberg Hessen, Mannheim, Germany
    Stem Cells 24:1294-301. 2006
  5. ncbi Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    Massimo Di Nicola
    Cristina Gandini Bone Marrow Transplantation Unit, Istituto Nazionale Tumori, Milano, Italy
    Blood 99:3838-43. 2002
  6. pmc Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production
    Krisztian Nemeth
    National Institute of Dental and Craniofacial Research NIDCR, Craniofacial and Skeletal Diseases Branch, NIH, Bethesda, MD 20892, USA
    Nat Med 15:42-9. 2009
  7. ncbi RAG-1-deficient mice have no mature B and T lymphocytes
    P Mombaerts
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139
    Cell 68:869-77. 1992
  8. ncbi Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Nat Immunol 7:311-7. 2006
  9. ncbi Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation
    Roland Meisel
    Clinic of Pediatric Oncology, Hematology and Immunology, University Hospital, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Blood 103:4619-21. 2004
  10. ncbi Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo
    Amelia Bartholomew
    University of Illinois, Chicago 60607, USA
    Exp Hematol 30:42-8. 2002

Detail Information

Publications284 found, 100 shown here

  1. ncbi Multilineage potential of adult human mesenchymal stem cells
    M F Pittenger
    Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231 3043, USA
    Science 284:143-7. 1999
    ..These adult stem cells could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages. Individual stem cells were identified that, when expanded to colonies, retained their multilineage potential...
  2. ncbi Marrow stromal cells as stem cells for nonhematopoietic tissues
    D J Prockop
    Center for Gene Therapy, Allegheny University of the Health Sciences, MCP Hahnemann School of Medicine, 245 North 15 Street, Mail Stop 421, Philadelphia, PA 19102, USA
    Science 276:71-4. 1997
    ..Therefore, marrow stromal cells present an intriguing model for examining the differentiation of stem cells. Also, they have several characteristics that make them potentially useful for cell and gene therapy...
  3. ncbi Pluripotency of mesenchymal stem cells derived from adult marrow
    Yuehua Jiang
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 418:41-9. 2002
    ..As MAPCs proliferate extensively without obvious senescence or loss of differentiation potential, they may be an ideal cell source for therapy of inherited or degenerative diseases...
  4. ncbi Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue
    Susanne Kern
    Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden Württemberg Hessen, Mannheim, Germany
    Stem Cells 24:1294-301. 2006
    ..Both UCB and AT are attractive alternatives to BM in isolating MSC: AT as it contains MSCs at the highest frequency and UCB as it seems to be expandable to higher numbers...
  5. ncbi Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    Massimo Di Nicola
    Cristina Gandini Bone Marrow Transplantation Unit, Istituto Nazionale Tumori, Milano, Italy
    Blood 99:3838-43. 2002
    ....
  6. pmc Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production
    Krisztian Nemeth
    National Institute of Dental and Craniofacial Research NIDCR, Craniofacial and Skeletal Diseases Branch, NIH, Bethesda, MD 20892, USA
    Nat Med 15:42-9. 2009
    ....
  7. ncbi RAG-1-deficient mice have no mature B and T lymphocytes
    P Mombaerts
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139
    Cell 68:869-77. 1992
    ..Although RAG-1 expression has been reported in the central nervous system of the mouse, no obvious neuroanatomical or behavioral abnormalities have been found in the RAG-1-deficient mice...
  8. ncbi Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Nat Immunol 7:311-7. 2006
    ..Thus, CCR2-mediated signals in bone marrow determine the frequency of Ly6C(hi) monocytes in the circulation...
  9. ncbi Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation
    Roland Meisel
    Clinic of Pediatric Oncology, Hematology and Immunology, University Hospital, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Blood 103:4619-21. 2004
    ..As IDO-mediated T-cell inhibition depends on MSC activation, modulation of IDO activity might alter the immunosuppressive properties of MSCs in different therapeutic applications...
  10. ncbi Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo
    Amelia Bartholomew
    University of Illinois, Chicago 60607, USA
    Exp Hematol 30:42-8. 2002
    ..We hypothesized that the activities of MSCs in the bone marrow microenvironment might also include immunomodulatory effects on lymphocytes...
  11. ncbi Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms
    Florian Tögel
    Division of Nephrology, University of Utah, Salt Lake City, UT 84148, USA
    Am J Physiol Renal Physiol 289:F31-42. 2005
    ....
  12. pmc Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing
    Liwen Chen
    Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 3:e1886. 2008
    ..Our results suggest that factors released by BM-MSCs recruit macrophages and endothelial lineage cells into the wound thus enhancing wound healing...
  13. pmc Identification of splenic reservoir monocytes and their deployment to inflammatory sites
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Science 325:612-6. 2009
    ..These observations uncover a role for the spleen as a site for storage and rapid deployment of monocytes and identify splenic monocytes as a resource that the body exploits to regulate inflammation...
  14. ncbi Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
    T Asahara
    Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Circ Res 85:221-8. 1999
    ....
  15. pmc Bone marrow-derived mesenchymal stem cells in repair of the injured lung
    Mauricio Rojas
    Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Research of the Lung, Department of Medicine, Emory University School of Medicine and Atlanta Veterans Affairs Medical Center, Atlanta, GA 30322, USA
    Am J Respir Cell Mol Biol 33:145-52. 2005
    ..BMDMSC localize to the injured lung and assume lung cell phenotypes, but protection from injury and fibrosis also involves suppression of inflammation and triggering production of reparative growth factors...
  16. ncbi Adult rat and human bone marrow stromal cells differentiate into neurons
    D Woodbury
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci Res 61:364-70. 2000
    ..Consequently, adult marrow stromal cells can be induced to overcome their mesenchymal commitment and may constitute an abundant and accessible cellular reservoir for the treatment of a variety of neurologic diseases...
  17. pmc In vivo analysis of dendritic cell development and homeostasis
    Kang Liu
    Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA
    Science 324:392-7. 2009
    ..Further cDC development involves cell division, which is controlled in part by regulatory T cells and fms-like tyrosine kinase receptor-3...
  18. ncbi Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
    Alexander Mildner
    Institute of Neuropathology, Georg August University, Gottingen, Germany
    Nat Neurosci 10:1544-53. 2007
    ..Our results identify Ly-6C(hi)CCR2(+) monocytes as direct precursors of microglia in the adult brain and establish the importance of local factors in the adult CNS for microglia engraftment...
  19. ncbi VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells
    Myriam Grunewald
    Department of Molecular Biology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Cell 124:175-89. 2006
    ..Together, the data suggest a model for VEGF-programmed adult neovascularization highlighting the essential paracrine role of recruited myeloid cells and a role for SDF1 in their perivascular retention...
  20. ncbi Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
    Fumio Arai
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo, 160 8582, Japan
    Cell 118:149-61. 2004
    ..These data suggest that the Tie2/Ang-1 signaling pathway plays a critical role in the maintenance of HSCs in a quiescent state in the BM niche...
  21. ncbi Endothelial progenitor cells: characterization and role in vascular biology
    Carmen Urbich
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circ Res 95:343-53. 2004
    ..This review summarizes the mechanisms regulating endothelial progenitor cell-mediated neovascularization and reendothelialization...
  22. ncbi Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    Alain R Simard
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, 2705 Laurier Boul, Quebec G1V 4G2, Canada
    Neuron 49:489-502. 2006
    ..Therapeutic strategies aiming to improve their recruitment could potentially lead to a new powerful tool for the elimination of toxic senile plaques...
  23. ncbi Endothelial progenitor cells: identity defined?
    Frank Timmermans
    Department of Clinical Chemistry, Microbiology and Immunology, University of Ghent, University Hospital Ghent, De Pintelaan, Ghent, Belgium
    J Cell Mol Med 13:87-102. 2009
    ..We also discuss our recent findings on the origin of endothelial outgrowth cells (EOCs), showing that this in vitro defined EC population does not originate from circulating CD133(+) cells or CD45(+) haematopoietic cells...
  24. ncbi An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
    M B Lutz
    Department of Dermatology, University of Erlangen, Germany
    J Immunol Methods 223:77-92. 1999
    ..of bone marrow cell subpopulations to circumvent loss of precursors, (ii) a lower plating density of bone marrow cells, (iii) a prolonged culture period of 10-12 days, (iv) the reduction of the GM-CSF dose from day 8 or 10 ..
  25. ncbi Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation
    William T Tse
    Division of Hematology Oncology, Children s Hospital, Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    Transplantation 75:389-97. 2003
    ..To assess the feasibility of human MSC transplantation, we evaluated the in vitro immunogenicity of MSC and their ability to function as alloantigen presenting cells (APC)...
  26. ncbi Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide
    Mauro Krampera
    Department of Immunology and Transplantation Biology, Imperial College Faculty of Medicine, Hammersmith Hospital, London, United Kingdom
    Blood 101:3722-9. 2003
    ..We conclude that MSCs inhibit naive and memory T-cell responses to their cognate antigens. Overall our data suggest that MSCs physically hinder T cells from the contact with APCs in a noncognate fashion...
  27. pmc Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites
    Chia Lin Tsou
    Gladstone Institute of Cardiovascular Disease, UCSF, San Francisco, California 94158, USA
    J Clin Invest 117:902-9. 2007
    ..These findings provide evidence that CCR2 and MCP-3/MCP-1 are critical for monocyte mobilization and suggest new roles for monocyte chemoattractants in leukocyte homeostasis...
  28. ncbi Purification and characterization of mouse hematopoietic stem cells
    G J Spangrude
    Department of Pathology, Stanford University School of Medicine, CA 94305
    Science 241:58-62. 1988
    ..Thirty of these cells are sufficient to save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the survivors...
  29. pmc Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
    H Yasuda
    Research Institute of Life Science, Snow Brand Milk Products Co, Ltd, 519 Ishibashi machi, Shimotsuga gun, Tochigi 329 0512, Japan
    Proc Natl Acad Sci U S A 95:3597-602. 1998
    ..ODF was found to be identical to TRANCE/RANKL, which enhances T-cell growth and dendritic-cell function. ODF seems to be an important regulator in not only osteoclastogenesis but also immune system...
  30. ncbi Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood
    Wolfgang Wagner
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Exp Hematol 33:1402-16. 2005
    ..Whereas surface antigen markers have failed to precisely define this population, microarray analysis might provide a better tool for characterization of MSC...
  31. ncbi Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source
    Yusuke Sakaguchi
    Tokyo Medical and Dental University, Japan
    Arthritis Rheum 52:2521-9. 2005
    ..To compare the properties of human mesenchymal stem cells (MSCs) isolated from bone marrow, synovium, periosteum, skeletal muscle, and adipose tissue...
  32. ncbi Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex
    K Le Blanc
    Division of Clinical Immunology Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Scand J Immunol 57:11-20. 2003
    ..The effect of a larger number of MSCs on MLCs seems more dependent on cell dose than histocompatibility and could result from an 'overload' of a stimulatory mechanism...
  33. ncbi Mesenchymal stem cells and their potential as cardiac therapeutics
    Mark F Pittenger
    Osiris Therapeutics, Inc, 2001 Aliceanna St, Baltimore, MD 21231, USA
    Circ Res 95:9-20. 2004
    ....
  34. ncbi The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities
    Adriana López Ponte
    Laboratoire d Hématopoïèse, Institut National de la Santé et de la Recherche Médicale ER15, IFR135 Université François Rebelais, Tours, France
    Stem Cells 25:1737-45. 2007
    ..Our results suggest that the mobilization of MSCs and their subsequent homing to injured tissues may depend on the systemic and local inflammatory state. Disclosure of potential conflicts of interest is found at the end of this article...
  35. ncbi Adult bone marrow stromal cells differentiate into neural cells in vitro
    J Sanchez-Ramos
    Department of Neurology, University of South Florida, Tampa, USA
    Exp Neurol 164:247-56. 2000
    Bone marrow stromal cells (BMSC) normally give rise to bone, cartilage, and mesenchymal cells. Recently, bone marrow cells have been shown to have the capacity to differentiate into myocytes, hepatocytes, and glial cells...
  36. ncbi Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling
    Ryota Uemura
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0529, USA
    Circ Res 98:1414-21. 2006
    ..Preconditioning of BMSCs enhanced their survival and ability to attenuate LV remodeling, which was attributable, in part, to paracrine effects...
  37. ncbi SSEA-4 identifies mesenchymal stem cells from bone marrow
    Eun J Gang
    Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas 75390 9133, USA
    Blood 109:1743-51. 2007
    ....
  38. ncbi Stem-cell therapy for cardiac disease
    Vincent F M Segers
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Partners Research Facility, 65 Landsdowne Street, Cambridge, Massachusetts 02139, USA
    Nature 451:937-42. 2008
    ..These new findings have stimulated optimism that the progression of heart failure can be prevented or even reversed with cell-based therapy...
  39. ncbi Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells
    Mauro Krampera
    Department of Clinical and Experimental Medicine, University of Verona, Italy
    Stem Cells 24:386-98. 2006
    ..These findings suggest that the beneficial effect on graft-versus-host disease induced by in vivo coinfusion with the graft of MSCs may be due to the activation of the immunomodulatory properties of MSCs by T cell- derived IFN-gamma...
  40. pmc Cardiomyocytes can be generated from marrow stromal cells in vitro
    S Makino
    Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Invest 103:697-705. 1999
    ..These cells expressed Nkx2.5/Csx, GATA4, TEF-1, and MEF-2C mRNA before 5-azacytidine treatment and expressed MEF-2A and MEF-2D after treatment. This new cell line provides a powerful model for the study of cardiomyocyte differentiation...
  41. ncbi Bone marrow as a potential source of hepatic oval cells
    B E Petersen
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Science 284:1168-70. 1999
    ..From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability...
  42. ncbi Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis
    Dingcheng Gao
    Cancer Genome Research Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 319:195-8. 2008
    ..These findings establish the role of EPCs in metastatic progression in preclinical models and suggest that selective targeting of EPCs may merit investigation as a therapy for cancer patients with lung metastases...
  43. ncbi Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta
    Pieternella S In 't Anker
    Department of Obstetrics, Lieden University Medical Center, Leiden, The Netherlands
    Stem Cells 22:1338-45. 2004
    ..Decidua basalis and decidua parietalis are sources for maternal MSCs. The expansion potency from both fetal and maternal placenta-derived MSCs was higher compared with adult bone marrow-derived MSCs...
  44. ncbi Gastric cancer originating from bone marrow-derived cells
    JeanMarie Houghton
    Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 306:1568-71. 2004
    ..These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression...
  45. ncbi Mesenchymal stem cells can be differentiated into endothelial cells in vitro
    Joachim Oswald
    Institute of Polymer Research Dresden and The Max Bergmann Center of Biomaterials Dresden, Dresden, Germany
    Stem Cells 22:377-84. 2004
    ..MSCs were generated out of mononuclear bone marrow cells from healthy donors separated by density gradient centrifugation...
  46. ncbi Bone marrow stromal stem cells: nature, biology, and potential applications
    P Bianco
    Dipartimento di Medicina Sperimentale e Patologia, Universita La Sapienza, Roma, Italy
    Stem Cells 19:180-92. 2001
    ..Along with an overview of the basics of their biology, we discuss here their potential nature as components of the vascular wall, and the prospects for their use in local and systemic transplantation and gene therapy...
  47. ncbi An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction
    Carl A Gregory
    Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Anal Biochem 329:77-84. 2004
    ..Although more labor intensive than CPC extraction, the protocol is more sensitive and yields more reliable results for weakly mineralizing samples...
  48. ncbi Comparison of multi-lineage cells from human adipose tissue and bone marrow
    Daniel A De Ugarte
    Departments of Surgery and Orthopaedics, UCLA School of Medicine, Los Angeles, California, USA
    Cells Tissues Organs 174:101-9. 2003
    ..Adipose tissue is an abundant and easily procured source of PLA cells, which have a potential like MSCs for use in tissue-engineering applications and as gene delivery vehicles...
  49. ncbi Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells
    Karin Stenderup
    University Department of Endocrinology and Metabolism, University Hospital of Aarhus, DK 8000 Aarhus C, Denmark
    Bone 33:919-26. 2003
    ..In conclusion, aging is associated with decreased proliferative capacity of osteoprogenitor cells, suggesting that decreased osteoblastic cell number, and not function, leads to age-related decrease in bone formation...
  50. ncbi Monitoring of bone marrow cell homing into the infarcted human myocardium
    Michael Hofmann
    Department of Nuclear Medicine, Hanover Medical School, Hanover, Germany
    Circulation 111:2198-202. 2005
    Intracoronary transfer of autologous bone marrow cells (BMCs) promotes recovery of left ventricular systolic function in patients with acute myocardial infarction...
  51. ncbi Mesenchymal stem cells reside in virtually all post-natal organs and tissues
    Lindolfo da Silva Meirelles
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Cell Sci 119:2204-13. 2006
    ..These findings have implications for understanding MSC biology, and for clinical and pharmacological purposes...
  52. pmc Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts
    Shuanhu Zhou
    Department of Orthopedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Aging Cell 7:335-43. 2008
    ..These findings support the view that there are intrinsic alterations in human MSCs with aging that may contribute to the process of skeletal aging in humans...
  53. ncbi Bone marrow stromal cells generate muscle cells and repair muscle degeneration
    Mari Dezawa
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoecho, Sakyo ku, Kyoto, 606 8501 Japan
    Science 309:314-7. 2005
    ..These MSCs represent a more ready supply of myogenic cells than do the rare myogenic stem cells normally found in muscle and bone marrow...
  54. pmc Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice
    L Boring
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco 94141 9100, USA
    J Clin Invest 100:2552-61. 1997
    ..These data suggest an important and unexpected role for CCR2 activation in modulating the immune response, as well as in recruiting monocytes/macrophages to sites of inflammation...
  55. ncbi In vitro expansion of human mesenchymal stem cells: choice of serum is a determinant of cell proliferation, differentiation, gene expression, and transcriptome stability
    Aboulghassem Shahdadfar
    Institute of Immunology, Rikshospitalet University Hospital, 0027 Oslo, Norway
    Stem Cells 23:1357-66. 2005
    ..Thus, hMSCs may be expanded rapidly and with stable gene expression in AS in the absence of growth factors, whereas FBS induces a more differentiated and less stable transcriptional profile...
  56. pmc Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation
    Konstantinos E Hatzistergos
    University of Miami Miller School of Medicine, Interdisciplinary Stem Cell Institute, Miami, FL 33136, USA
    Circ Res 107:913-22. 2010
    ..Bone marrow-derived mesenchymal stem cells (MSCs) have the capacity for cardiac repair that appears to exceed their capacity for differentiation into cardiac myocytes...
  57. pmc Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow
    Satoru Morikawa
    Department of Physiology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    J Exp Med 206:2483-96. 2009
    ..Naive MSCs resided in the perivascular region in a quiescent state. This study provides the useful method needed to identify MSCs as defined in vivo entities...
  58. ncbi Langerhans cells renew in the skin throughout life under steady-state conditions
    Miriam Merad
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94304, USA
    Nat Immunol 3:1135-41. 2002
    ..These data indicate that under steady-state conditions, LCs are maintained locally, but inflammatory changes in the skin result in their replacement by blood-borne LC progenitors...
  59. ncbi Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors
    Yuval Shaked
    Department of Molecular and Cellular Biology Research, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada
    Science 313:1785-7. 2006
    ..These findings also provide a mechanistic rationale for the enhanced efficacy of VDAs when combined with antiangiogenic drugs...
  60. ncbi Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
    T Nagasawa
    Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Japan
    Nature 382:635-8. 1996
    ..In addition, the mutants had a cardiac ventricular septal defect. Hence, we have shown that the chemokine PBSF/SDF-1 has several essential functions in development...
  61. ncbi G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
    Isabelle Petit
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Nat Immunol 3:687-94. 2002
    ..We suggest that manipulation of SDF-1 CXCR4 interactions may be a means with which to control the navigation of progenitors between the BM and blood to improve the outcome of clinical stem cell transplantation...
  62. ncbi Haematopoietic stem cell release is regulated by circadian oscillations
    Simon Mendez-Ferrer
    Mount Sinai School of Medicine, Department of Medicine and Department of Gene and Cell Medicine, New York, New York 10029, USA
    Nature 452:442-7. 2008
    ..These data indicate that a circadian, neurally driven release of HSC during the animal's resting period may promote the regeneration of the stem cell niche and possibly other tissues...
  63. ncbi Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp
    Songtao Shi
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    J Bone Miner Res 18:696-704. 2003
    ....
  64. ncbi Stromal cells protect against acute tubular injury via an endocrine effect
    Baoyuan Bi
    Section of Nephrology, Department of Medicine, Yale University, New Haven, Connecticut 06510, USA
    J Am Soc Nephrol 18:2486-96. 2007
    ..Identification of the stromal cell-derived protective factors may provide new therapeutic options to explore in humans with acute kidney injury...
  65. ncbi Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies
    A Stolzing
    Kroto Research Institute, North Campus, University of Sheffield, UK
    Mech Ageing Dev 129:163-73. 2008
    ..Furthermore, there is an age-related decline in overall BM MSC "fitness" which might lead to problems when using autologous aged MSC for cell-based therapies...
  66. pmc Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses
    Hirokazu Ohtaki
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 105:14638-43. 2008
    ..The observed beneficial effects of hMSCs were largely explained by their modulation of inflammatory and immune responses, apparently by alternative activation of microglia and/or macrophages...
  67. ncbi Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: short-term and long-term outcomes
    Liang Peng
    Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    Hepatology 54:820-8. 2011
    ..Additionally, there were no significant differences in the incidence of HCC or mortality between patients with and without cirrhosis in the transplantation group...
  68. ncbi CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system
    Alexander Mildner
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Brain 132:2487-500. 2009
    ..Collectively, these data indicate a disease-promoting role of CCR2+Ly-6Chi monocytes during autoimmune inflammation of the central nervous system...
  69. ncbi Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
    Manuel Alvarez-Dolado
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143 0520, USA
    Nature 425:968-73. 2003
    Recent studies have suggested that bone marrow cells possess a broad differentiation potential, being able to form new liver cells, cardiomyocytes and neurons...
  70. pmc The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues
    Claudia Waskow
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065, USA
    Nat Immunol 9:676-83. 2008
    ..In contrast, Flt3 was essential to the regulation of homeostatic DC development in the spleen, where it was needed to maintain normal numbers of DCs by controlling their division in the periphery...
  71. ncbi Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms
    T Kinnaird
    Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA
    Circ Res 94:678-85. 2004
    ..These data indicate that paracrine signaling is an important mediator of bone marrow cell therapy in tissue ischemia, and that cell incorporation into vessels is not a prerequisite for their effects...
  72. ncbi A population of very small embryonic-like (VSEL) CXCR4(+)SSEA-1(+)Oct-4+ stem cells identified in adult bone marrow
    M Kucia
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 20:857-69. 2006
    ..We hypothesize that this population of Sca-1(+)lin(-)CD45- very small embryonic-like (VSEL) stem cells is deposited early during development in BM and could be a source of pluripotent stem cells for tissue/organ regeneration...
  73. pmc Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment
    Olaia Naveiras
    Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Massachusetts 02115, USA
    Nature 460:259-63. 2009
    ..These data implicate adipocytes as predominantly negative regulators of the bone-marrow microenvironment, and indicate that antagonizing marrow adipogenesis may enhance haematopoietic recovery in clinical bone-marrow transplantation...
  74. ncbi Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro
    Thomas M Schmitt
    Department of Immunology, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Immunity 17:749-56. 2002
    ..Thus, it is likely that Delta-like-1/Notch interactions by the thymus underpin its unique ability to promote lineage commitment and differentiation of T cells...
  75. pmc Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice
    Ryang Hwa Lee
    Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 103:17438-43. 2006
    ..Therefore, the results raised the possibility that hMSCs may be useful in enhancing insulin secretion and perhaps improving the renal lesions that develop in patients with diabetes mellitus...
  76. pmc Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity
    Henry C Quevedo
    Interdisciplinary Stem Cell Institute and Department of Medicine, Cardiovascular Division, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 106:14022-7. 2009
    ..MSCs are an adult stem cell with the capacity for cardiomyogenesis and vasculogenesis which contribute, at least in part, to their ability to repair chronically scarred myocardium...
  77. ncbi Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow
    Stan Gronthos
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    J Cell Sci 116:1827-35. 2003
    ..Our novel selection protocol provides a means to generate purified populations of BMSSCs for use in a range of different tissue engineering and gene therapy strategies...
  78. ncbi Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells
    Elena A Jones
    University of Leeds, Leeds, UK
    Arthritis Rheum 46:3349-60. 2002
    ..The aim of this study was to isolate and characterize human bone marrow (BM) MPCs...
  79. ncbi In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells
    B Johnstone
    Skeletal Research Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Exp Cell Res 238:265-72. 1998
    ..These results provide histological, immunohistochemical, and molecular evidence for the in vitro chondrogenic differentiation of adult mammalian progenitor cells derived from bone marrow...
  80. pmc Identification of a novel population of Langerin+ dendritic cells
    Laura S Bursch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 204:3147-56. 2007
    ..This suggests that dermal LCs can mediate CHS and provides an explanation for previous differences observed in the two-model systems...
  81. ncbi Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells
    Sarah Glennie
    Department of Immunology and Transplantation Biology, Faculty of Medicine, Imperial College London, United Kingdom
    Blood 105:2821-7. 2005
    ..MSCs did not preferentially target any T-cell subset, and the inhibition was also extended to B cells. MSC-mediated inhibition induces an unresponsive T-cell profile that is fully consistent with that observed in division arrest anergy...
  82. ncbi Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow
    E Mezey
    Basic Neuroscience Program, Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Science 290:1779-82. 2000
    ..in a strain of mice incapable of developing cells of the myeloid and lymphoid lineages, transplanted adult bone marrow cells migrated into the brain and differentiated into cells that expressed neuron-specific antigens...
  83. ncbi Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy
    Noritoshi Nagaya
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka 565 8565, Japan
    Circulation 112:1128-35. 2005
    ..However, little information is available about the therapeutic potency of MSC transplantation in cases of dilated cardiomyopathy (DCM), an important cause of heart failure...
  84. ncbi Mesenchymal stem cells: biology and potential clinical uses
    R J Deans
    Osiris Therapeutics, Baltimore, MD 21231, USA
    Exp Hematol 28:875-84. 2000
    ..Preclinical and early clinical safety studies are paving the way for further applications of mesenchymal stem cells in the field of transplantation with respect to hematopoietic support, immunoregulation, and graft facilitation...
  85. ncbi Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution
    Israel M Barbash
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer 52621, Israel
    Circulation 108:863-8. 2003
    ..Systemic delivery of bone marrow-derived mesenchymal stem cells (BM-MSCs) is an attractive approach for myocardial repair. We aimed to test this strategy in a rat model after myocardial infarction (MI)...
  86. pmc The stem cell niches in bone
    Tong Yin
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    J Clin Invest 116:1195-201. 2006
    ..Many of the discoveries described herein may contribute to future clinical treatments for hematopoietic and bone-related disorders, including cancer...
  87. ncbi Transdifferentiation potential of human mesenchymal stem cells derived from bone marrow
    Lin Song
    Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 8022, USA
    FASEB J 18:980-2. 2004
    ..Our results showed that fully differentiated cells from hMSCs were capable of dedifferentiation and transdifferentiation into cells of another developmental lineage at single cell levels...
  88. pmc Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
    Kalindi Parmar
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:5431-6. 2007
    ....
  89. ncbi A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow
    Masoud Soleimani
    Department of Hematology, Faculty of Medical Science, Tarbiat Modares University, PO Box, 14115 111, Tehran, Iran
    Nat Protoc 4:102-6. 2009
    ..5 ml of 0.25% trypsin containing 0.02% ethylenediaminetetraacetic acid for 2 min at room temperature (25 degrees C). A purified population of MSCs can be obtained 3 weeks after the initiation of culture...
  90. ncbi SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells
    Elena De Falco
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    Blood 104:3472-82. 2004
    ..Our findings unravel a function for SDF-1 in increase of EPC number and formation of vascular structures by bone marrow progenitor cells...
  91. ncbi Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats
    Suguru Oyagi
    Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871 Japan
    J Hepatol 44:742-8. 2006
    The autologous transplantation of bone marrow cells is a promising treatment for liver disease...
  92. ncbi The endosteal 'osteoblastic' niche and its role in hematopoietic stem cell homing and mobilization
    J P Levesque
    Biotherapies Program, Haematopoietic Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, Queensland, Australia
    Leukemia 24:1979-92. 2010
    ..The second part of this article reviews the current knowledge of the mechanisms of HSC lodgment into, retention in and mobilization from osteoblastic niches...
  93. ncbi Mesenchymal stromal cells: facilitators of successful transplantation?
    Karen English
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, OX3 9DU Oxford, UK
    Cell Stem Cell 7:431-42. 2010
    ..This review examines the in vitro and in vivo evidence for the clinical use of bone marrow derived MSCs...
  94. pmc Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
    Andrew Chow
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 208:261-71. 2011
    ..Thus, strategies that target BM MΦ hold the potential to augment stem cell yields in patients that mobilize HSCs/progenitors poorly...
  95. pmc Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells
    Robert E Schwartz
    Stem Cell Institute, University of Minnesota, Minneapolis 55455, USA
    J Clin Invest 109:1291-302. 2002
    ..MAPCs may therefore be an ideal cell for in vivo therapies for liver disorders or for use in bioartificial liver devices...
  96. pmc Identification of the earliest natural killer cell-committed progenitor in murine bone marrow
    John W Fathman
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Blood 118:5439-47. 2011
    ..Taken together, our data provide a high-resolution in vivo analysis of the earliest steps of NK cell commitment and maturation...
  97. ncbi Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial
    Stefan Janssens
    Department of Cardiology, Gasthuisberg University Hospital, University of Leuven, Leuven, Belgium
    Lancet 367:113-21. 2006
    ..Our aim was to investigate the effect of autologous bone marrow-derived stem cell (BMSC) transfer in the infarct-related artery on LV function and structure...
  98. pmc Bone marrow-derived progenitor cells in pulmonary fibrosis
    Naozumi Hashimoto
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Invest 113:243-52. 2004
    ..Thus the collagen-producing lung fibroblasts in pulmonary fibrosis can also be derived from BM progenitor cells...
  99. ncbi Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion
    Melissa A Baxter
    Stem Cell Research Group, Giving for Living Postgraduate Centre, Royal Manchester Children s Hospital, M27 4HA, UK
    Stem Cells 22:675-82. 2004
    ..We report that even protocols that involve minimal expansion induce a rapid aging of MSCs, with losses equivalent to about half their total replicative lifespan...
  100. ncbi Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscle
    Hideya Yoshimura
    Section of Orthopaedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Cell Tissue Res 327:449-62. 2007
    ..In particular, synovium-derived cells had the greatest potential for both proliferation and chondrogenesis, indicating their usefulness for cartilage study in a rat model...
  101. ncbi Aging, progenitor cell exhaustion, and atherosclerosis
    Frederick M Rauscher
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Box 3845, Durham, NC 27710, USA
    Circulation 108:457-63. 2003
    ..We hypothesize that the effect of time in atherosclerosis progression is related to obsolescence of endogenous progenitor cells that normally repair and rejuvenate the arteries...

Research Grants78

  1. Group X sPLA2: Regulator of lipolysis and glucose homeostasis
    Nancy R Webb; Fiscal Year: 2013
    ..performing a bone marrow transplant experiment in which wild-type and GX KO mice will be reconstituted with bone marrow cells derived from either wild-type or GX KO mice...
  2. GENETIC ANALYSIS OF POLARITY
    RUTH M STEWARD; Fiscal Year: 2010
    ..isoform is not detected in these leukemic samples, but is the only PDCD2 isoform present in normal human bone marrow cells, implying that the 48kD protein plays a role in normal hematopoiesis...
  3. Preclinical Development of JS-K, a Novel NO-Generating Prodrug for Cancer
    Paul J Shami; Fiscal Year: 2012
    ..Nitric oxide (NO) is well known to kill cancer cells without harming normal bone marrow cells, but until now has not been used directly to treat cancer because of its effect to lower blood pressure...
  4. Molecular Mechanisms of Disease Progression in Myeloid Malignancy
    ELIZABETH ANN EKLUND; Fiscal Year: 2013
    ..found a Gas2-dependent decrease in calpain activity and increase in bcatenin in Bcr-abl+ or Icsbp-/- murine bone marrow cells. Stat3, Stat5 and Xiap proteins are also increased in Icsbp-/- cells in a Gas2/calpain-dependent manner...
  5. A novel telomerase expressing lung fibroblast phenotype
    Sem H Phan; Fiscal Year: 2012
    ..It is hoped that attainment of the study's objectives will provide new ideas for effective treatment and management of these diseases. ..
  6. Use of umbilical cord as a unique stem cell source for tissue regeneration
    Xiao Dong Chen; Fiscal Year: 2013
    ..Our previous studies demonstrated that cellular extracellular matrix (ECM) made by bone marrow cells enhanced MSC attachment and proliferation, and retained their stem cell properties (Chen, et al, 2007, JBMR, ..
  7. Long-Acting G-CSF Analog for Treating ARS
    GEORGE NORBERT COX; Fiscal Year: 2013
    ..Granulocyte colony-stimulating factor (G- CSF) is a 19 kDa protein that stimulates bone marrow cells to divide and differentiate into neutrophils...
  8. Novel Hematopoietic Conditioning Agents for Treatment of Hematological Diseases
    Olga B Chernova; Fiscal Year: 2010
    ..of hematopoietic origin, including a panel of human leukemia cell lines, normal human blood cells and mouse bone marrow cells. Our preliminary screening provides proof-of-principle evidence that specific targeting of the hematopoietic ..
  9. GM-CSF analogs for treating acute radiation syndrome
    GEORGE NORBERT COX; Fiscal Year: 2010
    ..Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a 14 kDa cytokine that stimulates bone marrow cells to divide and differentiate into neutrophils and macrophages...
  10. Dietary Scavenging of Reactive Species in Lung Injury: Role of Macrophages
    THEA NOREEN GOLDEN; Fiscal Year: 2013
    ..Chimeric mice, created by adoptive transfer of green fluorescent protein positive bone marrow cells to wild type recipients, will serve to identif the recruited and resident cell populations...
  11. The Role of PKR in a Novel IL-3 Signal Transduction Pathway
    William Stratford May; Fiscal Year: 2012
    ..that the RAX- PKR stress signaling pathway may be critical for maintaining the correct composition of bone marrow cells and for initiating the response to infection from foreign agents...
  12. Combined neuroprotection and metabolic correction to treat leukodystrophies
    ERNESTO ROQUE BONGARZONE; Fiscal Year: 2013
    ..to provide the missing enzyme to myelinating glia via infiltrating macrophages after the transplantation of bone marrow cells (BMT) from healthy donors into affected patients...
  13. The relative roled of sex and genes during development of systemic autoimmunity
    TRINE NORGAARD JORGENSEN; Fiscal Year: 2010
    ..the effects of genes and hormones on the immune system in vivo we have found that even before puberty female bone marrow cells express an intrinsic capacity to drive accelerated lupus-like disease development in a hormone independent ..
  14. Abnormal Bone Marrow Cells and Diabetic Neuropathy
    Lawrence Chan; Fiscal Year: 2013
    ..The proposed research on the role and mechanism of high glucose-induced PI-BMDCs and PI-BMDC-neuron cell fusion may lead to a fundamental change in our understanding of the pathogenesis of diabetic neuropathy. ..
  15. Lentiviral-transduced hematopoictic stem cell transplantation for cystinosis
    Stephanie Cherqui; Fiscal Year: 2013
    ..Our preliminary data showed that transplantation of syngeneic whole bone marrow cells (BMC) or purified hematopoietic stem cells (HSC) expressing Ctns resulted in tissue engraftment of BMC or ..
  16. Lung and bone marrow crosstalk during a respiratory infection
    CAROLINA B LOPEZ; Fiscal Year: 2010
    ..The interaction between lung-derived signals and bone marrow cells during a respiratory virus infection has been overlooked...
  17. Effect of constitutive Type 2 NF-kB on adipogenesis
    LOTUS KYI LOO; Fiscal Year: 2010
    ..To accomplish all 4 Aims, we will use tissues, fibroblast cells and bone marrow cells from TRAF3-/-, NIK-/-, p100-/-, TRAF3-/- NIK-/-, TRAF3-/-p100-/-mice as well as 3T3-L1, ST2 and 3T3-F422A ..
  18. The role of ICSBP in the pathogenesis of chronic myeloid leukemia
    ELIZABETH ANN EKLUND; Fiscal Year: 2013
    ..We found a Gas2/calpain-dependent increase in ?catenin in Bcr-abl+ or Icsbp-/- murine bone marrow cells. Stat5 and Xiap are also increased in Icsbp-/- cells in a Gas2/calpain-dependent manner...
  19. MEPRINS-METALLOPROTEINASES OF THE KIDNEY AND INTESTINE
    Judith S Bond; Fiscal Year: 2010
    ..b>Bone marrow cells from wild-type and meprin knockout mice will be destroyed by radiation, and replaced by donor leukocytes ..
  20. Novel Strategies for Treatment of Myeloproliferative Disorders
    Roya Khosravi-Far; Fiscal Year: 2012
    ..hematopoietic cells expressing Bcr-Abl and a wild-type (wt) or a constitutively active FOXO3a;B) primary bone marrow cells from FoxO3-null or control mice retrovirally transduced with Bcr-Abl alone or in combination with wt or ..
  21. Study DNA repair in preventing MDS and AML after radiation and benzene exposure
    EDWARD PAUL HASTY; Fiscal Year: 2013
    ..role that DNA damage/repair plays in disease progression, the impact these genotoxins have on a variety of bone marrow cells including HSCs and vulnerable times of exposure (embryonic development vs. adult)...
  22. Long-Acting G-CSF analogs for treating acute radiation syndrome
    GEORGE NORBERT COX; Fiscal Year: 2010
    ..Granulocyte colony-stimulating factor (G-CSF) is a 19 kDa protein that stimulates bone marrow cells to divide and differentiate into neutrophils...
  23. Slit2-mediated expansion of primitive hematopoietic stem cell populations for tra
    Gary Van Zant; Fiscal Year: 2010
    ..A retrovirus was used to stably infect B6 bone marrow cells, which normally do not express Slit2, with a Slit2-containing GFP vector...
  24. Transactivation of Fetal Hemoglobin
    Kenneth R Peterson; Fiscal Year: 2011
    ..promoter- green fluorescent protein (GFP) fusion in ?-globin locus yeast artificial chromosome (?-YAC) bone marrow cells (BMCs) derived from transgenic mice to identify new transactivators of 3-globin synthesis that may or may ..
  25. Disease-Modifying Effects of Filgastrim in a Mouse Model of AD
    Juan R Sanchez-Ramos; Fiscal Year: 2012
    ..Chimeric tg AD mice engrafted with green fluorescent protein expressing (GFP+) bone marrow cells will be generated to determine the extent to which peripherally derived microglia and other bone marrow-..
  26. MECHANISMS OF ALLOGENEIC STEM CELL EDUCATION IN SCID
    Rebecca H Buckley; Fiscal Year: 2010
    ..SCID) given transplants of rigorously T cell-depleted HLA- identical or haploidentical related bone marrow cells without pre-transplant chemotherapy or post-transplant infants 1) To possible roles of (Op graft-versus-host ..
  27. Long-acting growth factors for treating the acute and long term effects of lethal
    Christie M Orschell; Fiscal Year: 2013
    ..G-CSF, GM- CSF and IL-11 are hematopoietic growth factors that stimulate bone marrow cells to divide and differentiate into neutrophils (G-CSF and GM-CSF) or platelets (IL-11)...
  28. EMBRYONIC STEM CELLS INDUCE SPECIFIC GRAFT TOLERANCE
    Nicholas Zavazava; Fiscal Year: 2012
    ..Due to the severity of the pre-conditioning regimens required to protect bone marrow cells from rejection, this procedure is often associated with significant morbidity and economic cost, limiting ..
  29. Role of Darc-Chemokine Interaction in the Trafficking of Osteoclast Precursors
    Bouchra Edderkaoui; Fiscal Year: 2012
    ..of mechanism by which Darc regulates osteoclasts, our preliminary studies have shown that 1) M-CSF dependent bone marrow cells derived from Darc-knockout (Darc-KO) mice exhibit reduced binding to chemokines such as MCP-1 and RANTES;2) ..
  30. Effect of Bone Marrow Cells on the Radiosensitivity of Brain and Mouth Cancers
    JOHN MARTIN BROWN; Fiscal Year: 2012
    ..test imatinib mesylate (GleevecTM) to block the mobilization of BMDCs by inhibition of the receptor c-kit on bone marrow cells. To determine the contribution of BMDCs to tumor growth after irradiation we will replace the bone marrow in ..
  31. Delta-like ligand 4+ dendritic cells and induction of alloimmunity
    Yi Zhang; Fiscal Year: 2013
    ..responses;3) Flt3L and Toll-like receptor signaling were essential for induction of Dll4+DCs from cultured bone marrow cells. Inhibition of NF-?B signaling blocked the expression of Dll4 in Flt3L-induced DCs;4) Flt3L-induced Dll4+DCs ..
  32. Acute Hepatic Porphyrias: Pathogenesis &Treatment
    Makiko Yasuda; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The proposed research investigates whether transplantation of hepatocytes and bone marrow cells can treat Acute Intermittent Porphyria (AIP), a hepatic disorder resulting from the deficiency of an enzyme ..
  33. Multicenter Cartilage Repair Preclinical Trial in Horses
    Constance R Chu; Fiscal Year: 2010
    ..Two different strategies to select and concentrate pluripotential bone marrow cells for in vivo cartilage repair will be used...
  34. Complement and Osteoporosis
    Feng Lin; Fiscal Year: 2013
    ..Our in vitro studies revealed that bone marrow cells from complement receptor-deficient mice had decreased capacity to differentiate into functional osteoclasts...
  35. The roles of lipid metabolism in the maintenance of hematopoietic stem cells
    Keisuke Ito; Fiscal Year: 2013
    ..We will then determine, through the use of xenograft mouse models transplanted with human bone marrow cells, whether pharmacological activation of PPAR signaling induces a transplanted minimum number of human ..
  36. Regulation of normal and leukemic hematopoiesis by type I interferon
    Eric M Pietras; Fiscal Year: 2011
    ..of inflammatory proteins, affects the biology of hematopoietic stem cells (HSCs), a small population of bone marrow cells that generate all blood cells...
  37. The connection between Notch signaling and VEGFR1 in angiogenesis
    HASINA HAMILTON OUTTZ; Fiscal Year: 2011
    ..Notch function in vascular homeostasis and may suggest a novel role for Notch in recruitment and function of bone marrow cells at angiogenic sites...
  38. In vivo detection of involvement of endogenous BM progenitor cells in glioma
    Ali Syed Arbab; Fiscal Year: 2013
    ..chimeric mouse model where bone marrow of sub-lethally irradiated athymic mouse will be replaced by bone marrow cells collected from bone marrow of transgenic mouse (C57BL/6-Tg(UBC-GFP)30Scha/J) that express GFP protein under ..
  39. Identification of a novel population in the adult bone marrow
    Ernestina Schipani; Fiscal Year: 2012
    ..In order to start testing our hypotheses, we propose to investigate the identity of the novel bone marrow cells we have recently discovered, by studying whether they are transplantable and of hematopoietic origin, and ..
  40. Alcohol-induced Osteoimmunopathies: A Unifying Explanatory Mechanism
    ROBERT WADE SIGGINS; Fiscal Year: 2013
    ..Chronic alcohol consumption suppressed NOTCH activity in bone marrow cells of rhesus macaques...
  41. Alcohol-induced Osteoimmunopathies: A Unifying Explanatory Mechanism
    ROBERT WADE SIGGINS; Fiscal Year: 2012
    ..Chronic alcohol consumption suppressed NOTCH activity in bone marrow cells of rhesus macaques...
  42. Regulating Hematopoietic Stem Cell Homeostasis through GSK-3
    Wei Tong; Fiscal Year: 2013
    ..Specific aim 1 will rigorously test both the independent and overlapping functions of Gsk3a and Gsk3b in bone marrow cells using conditional gene knockouts...
  43. Toxicology studies for gene-modified stem cell transplantation for cystinosis
    Stephanie Cherqui; Fiscal Year: 2013
    ..of integrating viral vectors is the In Vitro Immortalization (IVIM) assay using murine lineage-negative bone marrow cells. Vector Copy Numbers (VCN) and Vector Integration Sites (VIS) will be determined in the final colonies and ..
  44. In vivo lentiviral transduction of bone marrow cells for hemophilia gene therapy
    Carol H Miao; Fiscal Year: 2013
    ..treat hemophilia A (HemA) by directly transferring lentiviral vectors encoding factor VIII (FVIII) gene into bone marrow cells. Current treatment of HemA patients involves repeated infusions of FVIII proteins which is both costly and ..
  45. BTK SIGNALING IN B CELL SURVIVAL BY BAFF-R
    Wasif N Khan; Fiscal Year: 2011
    ..consequence of Btk and its kinase domain in response to BAFF, Btk-deficient mice will be reconstituted with bone marrow cells expressing kinase-dead Btk and splenic immature B cells will be analyzed for BAFF-R signaling to NF-kB and ..
  46. SELF-RENEWAL IN LEUKEMIC STEM CELLS
    Li Chai; Fiscal Year: 2012
    ..More detailed studies have demonstrates that Bmi-1 is a direct target of SALL4 in bone marrow cells. Based on these findings, we hypothesize that deregulation of SALL4B plays a key role in promoting self-..
  47. Macrophage-mediated gene delivery of neurotrophic factors for Parkinson's disease
    Senlin Li; Fiscal Year: 2013
    ..can be achieved through its expression in macrophages / microglia by ex vivo transduction of HSC-containing bone marrow cells with lentiviral vectors carrying a cassette expressing GDNF driven by our MSP, followed by syngeneic ..
  48. Color-Coded Imaging of Pancreatic Cancer Microenvironment for Drug Discovery
    Meng Yang; Fiscal Year: 2013
    ..the tumor microenvironment of this model with stromal cells (macrophages, lymphocytes, dendritic, and bone marrow cells) harvested from ubiquitously-expressing GFP, RFP, CFP (blue) and GFP-RFP (yellow) transgenic immunocompetent ..
  49. Stem cells in liver regeneration: fusion or plasticity
    Bryon E Petersen; Fiscal Year: 2013
    ..Several studies have shown that bone marrow cells can differentiate into hepatocytes, and we have also shown that bone marrow (BM) cells are able to produce ..
  50. The role of PI3K/Akt pathway in the pathogenesis and treatment of Krabbe disease
    TUBA FEHR; Fiscal Year: 2012
    ..Current treatments using bone marrow cells from a healthy donor and transplanting them into affected children has had limited success, emphasizing the ..
  51. Role of TAB1-TAK1 signaling in tumor-associated macrophage survival
    September R Mihaly; Fiscal Year: 2013
    ..Transplanting wild type or Tab1-deleted bone marrow cells into tumor- bearing mice and measuring the effects on tumor size and multiplicity and on macrophage survival ..
  52. Development of novel anti-leukemia agents targeting the menin-MLL interaction
    Jolanta Grembecka; Fiscal Year: 2013
    ..Compounds will be tested for their activity in leukemia cells and on normal bone marrow cells to validate their mechanism of action and exclude compounds which might cause toxicity issues...
  53. Role of the STK Receptor in Erythropoiesis
    Pamela Hankey; Fiscal Year: 2009
    ..To do this, we have developed an in vitro system in which primary bone marrow cells lacking Sf-Stk can be reconstituted with wild-type and mutant forms of the receptor...
  54. ELANE and CSF3R mutations in severe congenital neutropenia
    Fan Dong; Fiscal Year: 2012
    ..effects of the truncated G-CSFR on NE expression and apoptosis induction by the NE mutant in primary human bone marrow cells. In aim 3, we will further explore the role of NE in the negative regulation of Stat5 expression/function ..
  55. Recruitment of bone marrow-derived cells required for beta cell regeneration
    Kristie Aamodt; Fiscal Year: 2013
    ..Then we will ascertain whether bone marrow cells with this same profile are capable of inducing ? cell proliferation following VEGF-A induction in islets ..
  56. Bioengineered factor VIII gene therapy for hemophilia A
    H Trent Spencer; Fiscal Year: 2012
    ..We have shown that transplantation of bone marrow cells genetically-modified to express an engineered factor VIII protein is a feasible treatment for hemophilia A...
  57. Role of Aryl hydrocarbon receptor (AhR) and RelB during the initiation of dendrit
    Christoph F A Vogel; Fiscal Year: 2010
    ..current proposal we will identify the role of AhR and AhR/RelB activity in the differentiation process of bone marrow cells derived from C57BL/6 wild type and AhR null (AhR-/-) mice into DC...
  58. HISTONE H3 METHYLATION AND EPIGENOMICS IN ACUTE LEUKEMIA
    Lukas D Wartman; Fiscal Year: 2013
    ..on mouse APL tumors with and without spontaneous Kdm6a deletions or mutations, and on RNA derived from bone marrow cells from young, male Vav-Cre mice hemizygous for the Kdm6a conditional allele, along with the appropriate ..
  59. Genetically Altered Mesenchymal Stem Cell;Paracrine Effect on Neovascularization
    Victor J Dzau; Fiscal Year: 2012
    ..In this study, we will examine the effects of these bone marrow cells in the development of new blood vessels in the infarcted heart...
  60. TREM2 regulation of macrophages in spinal cord injury and CNS endogenous repair
    Phillip G Popovich; Fiscal Year: 2013
    ..Indeed, intravenous delivery of bone marrow cells (the primary technique to be used in the proposed studies) has already been tried in SCI patients and ..
  61. Shp2 in Osteoclastogenesis and Bone Remodeling
    Wentian Yang; Fiscal Year: 2010
    ..My preliminary data demonstrate that mice lacking Shp2 in osteoclasts are osteopetrotic, and bone marrow cells from the mutant mice have impaired osteoclastogenesis ex vivo, implicating a critical role for Shp2 in ..
  62. Alcoholic Liver Diseases: Damage, Repair and Stem Cell Regeneration
    Zhaoli Sun; Fiscal Year: 2013
    ..Indeed, after five weeks of alcohol feeding the numbers of bone marrow cells staining for c-Kit and CXCR4 are markedly diminished, and these cells contain 8-OHdG, the stable oxidative ..
  63. Transcriptional regulatory mechanisms in B cell development and leukemogenesis
    Robert G Roeder; Fiscal Year: 2013
    ..functions of E2A-coactivator interactions in B cell development through differentiation assays with bone marrow cells from E2A-/- mice and through the generation and analysis of knockin E2A (AD1/2/3mutant), TAF4(TAFHmutant) ..
  64. Characterization and Functional Analysis of Breast Cancer Secreted Exosomes in Ma
    DAVID CHARLES LYDEN; Fiscal Year: 2013
    ..Finally, we will utilize animal models and 3D co-cultures to measure BC exosome interaction with bone marrow cells and whether exosomes elicit formation of pre-metastatic niches within the bone marrow or disrupt dormant ..
  65. Targeted Inhibition of Innate Immunosurveillance to Promote the Engraftment of He
    NATHANIEL FERNHOFF; Fiscal Year: 2013
    ..Without high-dose radiation or chemotherapy, donor bone marrow cells fail to engraft in host bone marrow...
  66. Integrin-Based Mechanisms in Terminal Erythroid Maturation
    David E Golan; Fiscal Year: 2013
    ..maturing erythroblasts form adhesive interactions with extracellular matrix components and with other bone marrow cells in their local microenvironment...
  67. Investigating the mechanism of ITGA4/6-mediated chemoprotection of ALL cells
    YONG MI KIM KIM; Fiscal Year: 2013
    ..Integrin [unreadable]4 mediates adhesion of hematopoietic cells onto bone marrow cells and has been implicated in CAM- DR of leukemia cells...
  68. PATHOBIOLOGY OF THE OSTEOCLAST IN PAGETS DISEASE
    G Roodman; Fiscal Year: 2002
    ..Recently, we cloned and sequence-analyzed a full-length Measles Virus Nucleocapsid (MVNP) cDNA from bone marrow cells from a Paget's patient...
  69. NUCLEOSIDES WITH DUAL ANTI-HIV AND HBV ACTIVITY
    RAYMOND SCHINAZI; Fiscal Year: 2009
    ..and in contrast to the toxic L-D4FC enantiomer, D-D4FC had no in vitro toxicity, and had no effect on human bone marrow cells or mitochondria! DMA synthesis...
  70. Donor CD8+ cell facilitates mixed chimerism in NOD mice
    Defu Zeng; Fiscal Year: 2005
    ..We have recently shown that, in the absence of irradiation, injection of high doses of donor bone marrow cells in combination with donor CD8+ T cells induces a mixed chimerism in prediabetic NOD mice preconditioned with ..
  71. Stem Cells and Ischemic Brain Injury
    Walter Low; Fiscal Year: 2003
    Studies of bone marrow cells have shown that they can restore neurologic function when transplanted into animals with ischemic brain injury...
  72. ROLE OF T LYMPHOCYTE FACTORS IN HEMOPOIESIS 0
    Michael Prystowsky; Fiscal Year: 1992
    ..During an inflammatory response this GM-CSF may act distally on bone marrow cells to increase the number of responding granulocytes and macrophages...
  73. Hematopoietic Stem Cells & Lympho-Hematopoiesis: Effect of Alcohol
    ROBERT WOLCOTT; Fiscal Year: 2007
    ..Vacuolization of bone marrow cells is common and, although rare, hypocellularity of the bone marrow has been observed...
  74. PRECLINICAL BRIDGE TO HUMAN TRANSPLANT TOLERANCE
    Judith Thomas; Fiscal Year: 2000
    ..limited lymphoid irradiation and splenectomy (LLlI/splx), followed by infusion of a subpopulation of donor bone marrow cells (DBMC)) have demonstrated development of specific donor unresponsiveness, chimerism, and acceptance of life-..
  75. Gene Therapy for Purine Nucleoside Phosphorylase Deficiency (PNP)
    Kevin Baker; Fiscal Year: 2007
    ..was a French trial of retroviral gene therapy for X-linked severe combined immunodeficiency (SCID), in which bone marrow cells from children deficient in the common gamma-chain for several cytokine receptors were exposed to a ..
  76. Osteogenesis: Potentiation With Bone Tropic Peptides
    Gary Balian; Fiscal Year: 2007
    ..In aim 1, the peptides that specifically bind to bone, and their putative receptors on bone or bone marrow cells will be identified...
  77. Cellular Cardiomyoplasty in Vitro: Host-Donor Cell Interactions
    Nenad Bursac; Fiscal Year: 2007
    ..While initial clinical implantations of autologous skeletal myoblasts and bone marrow cells have been promising, the intrinsic potential of these cells to affect electro-mechanical function of ..
  78. Proteomic Study of Megakaryocyte Transcriptional Control
    Alan Cantor; Fiscal Year: 2007
    Megakaryocytes are large polyploid bone marrow cells that play essential roles in hemostasis through the generation of platelets...