th1 cells

Summary

Summary: Subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.

Top Publications

  1. ncbi Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    Estelle Bettelli
    Center for Neurologic Diseases, Beth Israel Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 441:235-8. 2006
  2. ncbi A novel transcription factor, T-bet, directs Th1 lineage commitment
    S J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cell 100:655-69. 2000
  3. ncbi Interleukin-12 and the regulation of innate resistance and adaptive immunity
    Giorgio Trinchieri
    Laboratory for Immunological Research, Schering Plough Research Institute, 27 chemin des Peupliers, B P 11, 69571 Dardilly, France
    Nat Rev Immunol 3:133-46. 2003
  4. ncbi Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    Laurie E Harrington
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 6:1123-32. 2005
  5. pmc CD4 T cells: fates, functions, and faults
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 112:1557-69. 2008
  6. pmc The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    Meghan A Koch
    Benaroya Research Institute, Seattle, Washington, USA
    Nat Immunol 10:595-602. 2009
  7. pmc CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
    Charles F Anderson
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:285-97. 2007
  8. ncbi Transforming growth factor-beta induces development of the T(H)17 lineage
    Paul R Mangan
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    Nature 441:231-4. 2006
  9. ncbi The biology of NKT cells
    Albert Bendelac
    Howard Hughes Medical Institute, Committee on Immunology, Department of Pathology University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Immunol 25:297-336. 2007
  10. ncbi The immunology of susceptibility and resistance to Leishmania major in mice
    David Sacks
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 2:845-58. 2002

Detail Information

Publications298 found, 100 shown here

  1. ncbi Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    Estelle Bettelli
    Center for Neurologic Diseases, Beth Israel Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 441:235-8. 2006
    ..Our data demonstrate a dichotomy in the generation of pathogenic (T(H)17) T cells that induce autoimmunity and regulatory (Foxp3+) T cells that inhibit autoimmune tissue injury...
  2. ncbi A novel transcription factor, T-bet, directs Th1 lineage commitment
    S J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cell 100:655-69. 2000
    ..Thus, T-bet initiates Th1 lineage development from naive Thp cells both by activating Th1 genetic programs and by repressing the opposing Th2 programs...
  3. ncbi Interleukin-12 and the regulation of innate resistance and adaptive immunity
    Giorgio Trinchieri
    Laboratory for Immunological Research, Schering Plough Research Institute, 27 chemin des Peupliers, B P 11, 69571 Dardilly, France
    Nat Rev Immunol 3:133-46. 2003
    ....
  4. ncbi Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    Laurie E Harrington
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 6:1123-32. 2005
    ..These findings provide a basis for understanding how inhibition of IFN-gamma signaling enhances development of pathogenic T(H)-17 effector cells that can exacerbate autoimmunity...
  5. pmc CD4 T cells: fates, functions, and faults
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 112:1557-69. 2008
    ....
  6. pmc The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    Meghan A Koch
    Benaroya Research Institute, Seattle, Washington, USA
    Nat Immunol 10:595-602. 2009
    ....
  7. pmc CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
    Charles F Anderson
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:285-97. 2007
    ..The data demonstrate that IL-10-producing Th1 cells, activated early in a strong inflammatory setting as a mechanism of feedback control, are the principal ..
  8. ncbi Transforming growth factor-beta induces development of the T(H)17 lineage
    Paul R Mangan
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    Nature 441:231-4. 2006
    ..The action of TGF-beta on naive T cells is antagonized by interferon-gamma and IL-4, thus providing a mechanism for divergence of the T(H)1, T(H)2 and T(H)17 lineages...
  9. ncbi The biology of NKT cells
    Albert Bendelac
    Howard Hughes Medical Institute, Committee on Immunology, Department of Pathology University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Immunol 25:297-336. 2007
    ....
  10. ncbi The immunology of susceptibility and resistance to Leishmania major in mice
    David Sacks
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 2:845-58. 2002
    ..major-resistant mice have revealed complexities in the mechanisms responsible for acquired immunity, which necessitate the redesign of vaccines against Leishmania and other pathogens that require sustained cell-mediated immune responses...
  11. ncbi Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
    Patricia A Darrah
    Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, 40 Convent Drive, Bethesda, Maryland 20892, USA
    Nat Med 13:843-50. 2007
    ....
  12. ncbi Cloning of a new cytokine that induces IFN-gamma production by T cells
    H Okamura
    Department of Bacteriology, Hyogo College of Medicine, Nishinomiya, Japan
    Nature 378:88-91. 1995
    ..IGIF may be involved in the development of Th1 cells and also in mechanisms of tissue injury in inflammatory reactions.
  13. pmc Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice
    David Bending
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Clin Invest 119:565-72. 2009
    ..Induction of diabetes in NOD/SCID mice via adoptive transfer of Th1 cells from BDC2...
  14. ncbi TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    Marc Veldhoen
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Immunity 24:179-89. 2006
    ..Our data indicate that, in the presence of IL-6, TGFbeta1 subverts Th1 and Th2 differentiation for the generation of IL-17-producing T cells...
  15. ncbi Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology
    De Broski R Herbert
    University of Cape Town, Health Sciences Faculty, 7925 Cape Town, South Africa
    Immunity 20:623-35. 2004
    ..Together, this shows that alternative macrophages are essential during schistosomiasis for protection against organ injury through downregulation of egg-induced inflammation...
  16. ncbi The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
    Chen Zhu
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 6:1245-52. 2005
    ..These data suggest that the Tim-3-galectin-9 pathway may have evolved to ensure effective termination of effector T(H)1 cells...
  17. pmc Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
    R Bonecchi
    Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    J Exp Med 187:129-34. 1998
    ..It may also determine different susceptibility of Th1s and Th2s to human immunodeficiency virus strains using different fusion coreceptors...
  18. ncbi Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    Daniel J Cua
    Department of Immunology, DNAX Research Inc, Palo Alto, California 94304 1104, USA
    Nature 421:744-8. 2003
    ..In addition, we show that IL-23, unlike IL-12, acts more broadly as an end-stage effector cytokine through direct actions on macrophages...
  19. ncbi Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
    Laurent Monney
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 415:536-41. 2002
    ..b>Th1 cells produce cytokines (interferon (IFN)-gamma, interleukin (IL)-2, tumour-necrosis factor (TNF)-alpha and ..
  20. pmc Circulating Th17, Th22, and Th1 cells are increased in psoriasis
    Shinji Kagami
    Department of Dermatology, Oregon Health and Science University, Portland, Oregon, USA
    J Invest Dermatol 130:1373-83. 2010
    Th17, Th22, and Th1 cells are detected in psoriatic skin lesions and implicated in psoriasis pathogenesis, but inflammatory T cell numbers in blood, as well as the relative importance of each cell type, is unclear...
  21. ncbi Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells
    Michelle A Lowes
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York 10021, USA
    J Invest Dermatol 128:1207-11. 2008
    ..Th17 cells are a discrete population, separate from Th1 cells (which are also in psoriasis lesions), and Th2 cells...
  22. ncbi Toll-like receptors control activation of adaptive immune responses
    M Schnare
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Nat Immunol 2:947-50. 2001
    ..These results suggest that distinct pathways of the innate immune system control activation of the two effector arms of adaptive immunity...
  23. pmc Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
    M Paula Longhi
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 206:1589-602. 2009
    ..Therefore, the adjuvant action of poly IC requires a widespread innate type I IFN response that directly links antigen presentation by DCs to adaptive immunity...
  24. pmc Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor
    Lorenzo Cosmi
    Department of Internal Medicine and DENOTHE Center, University of Florence, Florence 50134, Italy
    J Exp Med 205:1903-16. 2008
    ..These findings implicate CD161 as a novel surface marker for human Th17 cells and demonstrate the exclusive origin of these cells from a CD161(+)CD4(+) T cell progenitor...
  25. ncbi CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice
    Damo Xu
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, Scotland, United Kingdom
    J Immunol 170:394-9. 2003
    ..Our results therefore document that CD4+CD25+ regulatory T cells suppress both Th1 and Th2 cells and that these regulatory T cells have a profound therapeutic potential against diseases induced by both Th1 and Th2 cells in vivo...
  26. pmc Late developmental plasticity in the T helper 17 lineage
    Yun Kyung Lee
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Immunity 30:92-107. 2009
    ..These results support a model of late Th17 developmental plasticity with implications for autoimmunity and host defense...
  27. ncbi Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    Susanne J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 295:338-42. 2002
    ..This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage...
  28. pmc Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice
    L Boring
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco 94141 9100, USA
    J Clin Invest 100:2552-61. 1997
    ..These data suggest an important and unexpected role for CCR2 activation in modulating the immune response, as well as in recruiting monocytes/macrophages to sites of inflammation...
  29. ncbi Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion
    Chengcan Yao
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Nat Med 15:633-40. 2009
    ..Thus, PGE2-EP4 signaling promotes immune inflammation through TH1 differentiation and TH17 expansion, and EP4 antagonism may be therapeutically useful for various immune diseases...
  30. pmc Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells
    Marion Pepper
    Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Immunity 35:583-95. 2011
    ..Thus, Th1 effector memory and follicular helper-like central memory cells are produced from early effector cell populations that diverge in response to signals from the IL-2 receptor, Bcl6, and B cells...
  31. pmc Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice
    Emily K Forbes
    The Jenner Institute, University of Oxford, Headington, Oxford, United Kingdom
    J Immunol 181:4955-64. 2008
    ..Successful immunization regimes appear to induce Ag-specific cells with abundant intracellular cytokine staining...
  32. ncbi The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses
    Giorgio Trinchieri
    Schering Plough Research Institute, Laboratory for Immunological Research, 69571 Dardilly, France
    Immunity 19:641-4. 2003
    ..2003; Villarino et al., 2003), indicate that they mediate complex and well-differentiated functions...
  33. pmc Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
    H Jonuleit
    Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
    J Exp Med 192:1213-22. 2000
    ..Furthermore, in coculture experiments these T cells inhibited the antigen-driven proliferation of Th1 cells in a contact- and dose-dependent, but antigen-nonspecific manner...
  34. ncbi Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer
    E Y Woo
    Department of Surgery, Abramson Family Cancer Research Institute, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 61:4766-72. 2001
    ..These observations provide evidence for the contribution of regulatory T cells to immune dysfunction in cancer patients...
  35. ncbi T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
    Eun Sook Hwang
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 307:430-3. 2005
    ..T-bet is essential for the development of Th1 cells, and GATA-3 performs an equivalent role in Th2 development...
  36. ncbi B cells regulate autoimmunity by provision of IL-10
    Simon Fillatreau
    University of Edinburgh, Institute of Cell, Animal and Population Biology, King s Buildings West Mains Road, Edinburgh EH9 3JT, UK
    Nat Immunol 3:944-50. 2002
    ..In the absence of IL-10 production by B cells, the pro-inflammatory type 1 immune response persisted and mice did not recover. These data show that B cell-derived IL-10 plays a key role in controlling autoimmunity...
  37. ncbi Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease
    Parris Kidd
    Altern Med Rev 8:223-46. 2003
    ..b>Th1 cells drive the type-1 pathway ("cellular immunity") to fight viruses and other intracellular pathogens, ..
  38. pmc Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis
    Yinyao Lin
    Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Immunity 31:799-810. 2009
    ..Together, these findings illustrate a biological function for IL-17A in regulating IL-12-Th1 cell immunity and host responses to an intracellular pathogen...
  39. ncbi Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions
    Ahmed N Hegazy
    Experimental Immunology, Department of Rheumatology and Clinical Immunology, Charite University Medicine Berlin, 10117 Berlin, Germany
    Immunity 32:116-28. 2010
    ..Stable coexpression of GATA-3 and T-bet provides a molecular concept for the long-term coexistence of Th2 and Th1 cell lineage characteristics in single memory T cells...
  40. pmc The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes
    Richard G Jenner
    MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London W1T 4JF, United Kingdom
    Proc Natl Acad Sci U S A 106:17876-81. 2009
    ..In Th1 cells, T-bet associates with genes of diverse function, including those with roles in transcriptional regulation, ..
  41. pmc T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses
    M J Townsend
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    J Exp Med 191:1069-76. 2000
    ..These data clearly demonstrate that T1/ST2 expression plays a role in the development of Th2-like cytokine responses and indicate that effector functions are inhibited in its absence...
  42. pmc Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes
    Anneli Jäger
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:7169-77. 2009
    ..Initially, IFN-gamma-producing Th1 cells and, more recently, IL-17-producing Th17 cells with specificity for myelin Ags have been implicated in EAE ..
  43. ncbi The two faces of IL-6 on Th1/Th2 differentiation
    Sean Diehl
    Immunobiology Program, Department of Medicine, University of Vermont, Given Medical Building D305, Burlington, VT 05405, USA
    Mol Immunol 39:531-6. 2002
    ..supressor of cytokine signaling (SOCS)-1 expression to interfere with IFNgamma signaling and the development of Th1 cells. Since IL-6 is abundantly produced by APC, it is a likely source of early Th1/Th2 control during CD4(+) T cell ..
  44. pmc Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
    Margarida Saraiva
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Immunity 31:209-19. 2009
    ..We showed that development of IL-10-producing Th1 cells required high T cell receptor (TCR) ligation, sustained ERK1 and ERK2 MAP kinases phosphorylation, and IL-12-..
  45. pmc IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice
    Stefan Haak
    Neuroimmunology Division, Institute of Experimental Immunology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    J Clin Invest 119:61-9. 2009
    ..We conclude therefore that both IL-17A and IL-17F, while prominently expressed by an encephalitogenic T cell population, may only marginally contribute to the development of autoimmune CNS disease...
  46. pmc Alternatively activated macrophages in helminth infections
    Timothy Kreider
    Department of Medicine, UMDNJ New Jersey Medical School, MSB 639, 185 South Orange Avenue, Newark, NJ 07103, USA
    Curr Opin Immunol 19:448-53. 2007
    ..In this review, we will discuss recent findings regarding the role of AAMPhis in the development of disease and host protection following helminth infection...
  47. pmc Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages
    Wei Liao
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 12:551-9. 2011
    ..Thus, IL-2 influences helper T cell differentiation by modulating the expression of cytokine receptors to help specify and maintain differentiated states...
  48. pmc IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation
    Wei Liao
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Curr Opin Immunol 23:598-604. 2011
    ..In this fashion, IL-2 can prime and potentially maintain Th1 and Th2 differentiation as well as expand such populations of cells, whereas it inhibits Th17 differentiation but also can expand Th17 cells...
  49. pmc Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells
    S J Szabo
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 185:817-24. 1997
    ..Thus, IFN-gamma may prevent early Th cells from premature commitment to the Th2 pathway. Controlling the expression of the IL-12R beta 2 subunit could be an important therapeutic target for the redirection of ongoing Th cell responses...
  50. pmc Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells
    Sarah P Collier
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 189:2084-8. 2012
    ..Our results suggest that TMEVPG1 belongs to the general class of lincRNAs that positively regulate gene transcription...
  51. pmc Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis
    Yoshiyasu Esaki
    Departments of Pharmacology and Anesthesiology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 107:12233-8. 2010
    ....
  52. ncbi T helper (h)1/Th2 and Leishmania: paradox rather than paradigm
    James Alexander
    Department of Immunology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, The Todd Wing, John Arbuthnott Building, 27 Taylor Street, Glasgow G4 0NR, UK
    Immunol Lett 99:17-23. 2005
    ..Clearly a reappraisal of our current understanding of the role of IL-4 and the Th2 response in the immunobiology of leishmaniasis is required and this review seeks to address this issue...
  53. ncbi Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production
    J P van Hamburg
    Department of Rheumatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Arthritis Rheum 63:73-83. 2011
    Both Th1 cells and Th17 cells have been recognized in rheumatoid arthritis (RA); however, it remains unclear whether Th1 cells and/or Th17 cells are involved in driving disease chronicity and destructiveness...
  54. ncbi M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells
    Moniek Heusinkveld
    Department of Clinical Oncology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands
    J Immunol 187:1157-65. 2011
    ..Notably, upon cognate interaction with Th1 cells, these tumor-induced M2 macrophages could be switched to activated M1-like macrophages that expressed high ..
  55. pmc Current views on the roles of Th1 and Th17 cells in experimental autoimmune encephalomyelitis
    Mohamed El-Behi
    Department of Neurology, Thomas Jefferson University, Ste 300 JHN, 900 Walnut Street, Philadelphia, PA 19107, USA
    J Neuroimmune Pharmacol 5:189-97. 2010
    ..In this review, we discuss recent findings on the roles of Th1 and Th17 cells in the pathogenesis of EAE...
  56. ncbi The expanding universe of T-cell subsets: Th1, Th2 and more
    T R Mosmann
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
    Immunol Today 17:138-46. 1996
    ....
  57. ncbi Tuberculosis is associated with a down-modulatory lung immune response that impairs Th1-type immunity
    Alexandre S Almeida
    Institute of Thoracic Diseases, Clementino Fraga Filho University Hospital of Federal University of Rio de Janeiro, Brazil
    J Immunol 183:718-31. 2009
    ..Our data highlight the potential application of immune mediators as surrogate markers for TB diagnosis or treatment response...
  58. ncbi Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    K Takeda
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 10:39-49. 1999
    ..The mice show a polarized immune response toward the Th1 type and develop chronic enterocolitis with age. Taken together, Stat3 plays a critical role in deactivation of macrophages and neutrophils mainly exerted by IL-10...
  59. ncbi IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection
    Masayuki Umemura
    Molecular Microbiology Group, Center of Molecular Biosciences, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903 0213, Japan
    J Immunol 178:3786-96. 2007
    ..These data suggest that IL-17 is an important cytokine in the induction of optimal Th1 response and protective immunity against mycobacterial infection...
  60. ncbi Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation
    Giorgos Bamias
    Digestive Health Center of Excellence, University of Virginia Health Sciences Center, PO Box 800708, Charlottesville, Virginia 22908, USA
    Gastroenterology 128:654-66. 2005
    ..In the present study we tested the hypothesis that TH2 cytokines also may participate in disease development in SAMP1/YitFc mice that spontaneously develop terminal ileitis with perianal manifestations...
  61. ncbi Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance
    Alberto Sanchez-Fueyo
    Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Immunol 4:1093-101. 2003
    ..Our data indicate that the Tim-3 pathway provides an important mechanism to down-regulate T(H)1-dependent immune responses and to facilitate the development of immunological tolerance...
  62. ncbi The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection
    Alejandro Villarino
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St, Philadelphia, PA 19104, USA
    Immunity 19:645-55. 2003
    ....
  63. ncbi Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance
    Catherine A Sabatos
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1102-10. 2003
    ..These data indicate that interaction of Tim-3 with Tim-3 ligand may serve to inhibit effector T(H)1 cells during a normal immune response and may be crucial for the induction of peripheral tolerance...
  64. pmc Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis
    Richard A O'Connor
    University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, Edinburgh, United Kingdom
    J Immunol 181:3750-4. 2008
    ..Our key observation is that only Th1 cells can access the noninflamed CNS...
  65. ncbi The hamster as a model of human visceral leishmaniasis: progressive disease and impaired generation of nitric oxide in the face of a prominent Th1-like cytokine response
    P C Melby
    Medical Service, Department of Veterans Affairs Medical Center, South Texas Veterans Health Care System, San Antonio, TX 78284, USA
    J Immunol 166:1912-20. 2001
    ..Thus, although a Th1-like cytokine response was prominent, the major antileishmanial effector mechanism that is responsible for control of infection in mice was absent throughout the course of progressive VL in the hamster...
  66. pmc Evidence that development of severe cardiomyopathy in human Chagas' disease is due to a Th1-specific immune response
    J A S Gomes
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Minas Gerais, Brazil
    Infect Immun 71:1185-93. 2003
    ..We hypothesize that an exacerbated production of IFN-gamma against Trypanosoma cruzi antigens favors the development of a strong Th1 response in CARD patients, which leads to progression of heart disease...
  67. pmc Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis
    D R Huang
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    J Exp Med 193:713-26. 2001
    ....
  68. pmc Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells
    Giorgio Napolitani
    Institute for Research in Biomedicine, Oncology Institute of Southern Switzerland, CH 6500, Bellinzona, Switzerland
    Nat Immunol 6:769-76. 2005
    ..These results identify a 'combinatorial code' by which DCs discriminate pathogens and suggest new strategies for promoting T helper type 1 responses...
  69. ncbi Immune regulation by helminth parasites: cellular and molecular mechanisms
    Rick M Maizels
    Institute for Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Nat Rev Immunol 3:733-44. 2003
    ..Long-lived parasites such as the helminths, however, are more remarkable for their ability to downregulate host immunity, protecting themselves from elimination and minimizing severe pathology in the host...
  70. pmc Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells
    Natalia Martin-Orozco
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Eur J Immunol 39:216-24. 2009
    ..neonate NOD mice, showed predominant IFN-gamma over IL-17 expression, indicating conversion of donor cells into Th1 cells. Moreover, diabetes progression in NOD...
  71. pmc Emerging Tim-3 functions in antimicrobial and tumor immunity
    Kaori Sakuishi
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Trends Immunol 32:345-9. 2011
    ..In contrast to this inhibitory effect on T cells, Tim-3-Gal-9 interaction promotes macrophage clearance of intracellular pathogens. Here, we focus on the emerging role for Tim-3 in tumor and antimicrobial immunity...
  72. pmc Rules of chemokine receptor association with T cell polarization in vivo
    C H Kim
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 108:1331-9. 2001
    ..coordinately expressing CXCR3 and CCR4, Th1 but not Th2 cells can be CXCR3(+)CCR4(-), and Th2 but only rare Th1 cells are CCR4(+)CXCR3(-)...
  73. pmc Mesenchymal stem cell effects on T-cell effector pathways
    Michelle M Duffy
    Regenerative Medicine Institute, National Centre for Biomedical Engineering Science and School of Medicine, Nursing and Health Sciences, Orbsen Building, National University of Ireland Galway, Ireland
    Stem Cell Res Ther 2:34. 2011
    ....
  74. pmc IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection
    Ana Paula Freitas do Rosario
    Division of Parasitology, Medical Research Council National Institute for Medical Research, London, NW7 1AA, United Kingdom
    J Immunol 188:1178-90. 2012
    ..Furthermore, we show that IFN-γ(+) Th1 cells are the main producers of IL-10 throughout acute infection, expressing high levels of CD44 and ICOS, and low ..
  75. pmc TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 202:1715-24. 2005
    ..These findings reveal a previously unappreciated role for TLR9 in the host response to M. tuberculosis and illustrate TLR collaboration in host resistance to a major human pathogen...
  76. ncbi Interleukin-18 regulates both Th1 and Th2 responses
    K Nakanishi
    Department of Immunology and Medical Zoology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Annu Rev Immunol 19:423-74. 2001
    ..Therefore, the functions of IL-18 in vivo are very heterogeneous and complicated. In principle, IL-18 enhances the IL-12-driven Th1 immune responses, but it can also stimulate Th2 immune responses in the absence of IL-12...
  77. ncbi Programming dendritic cells to induce T(H)2 and tolerogenic responses
    Bali Pulendran
    Emory Vaccine Center, Atlanta, Georgia, USA
    Nat Immunol 11:647-55. 2010
    ....
  78. pmc Th1 and Th17 cells: adversaries and collaborators
    Jesse M Damsker
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 1857, USA
    Ann N Y Acad Sci 1183:211-21. 2010
    ..However, further studies have suggested a more complex story. In models thought to be driven by Th1 cells, mice lacking the hallmark Th1 cytokine IFN-gamma were not protected but tended to have enhanced susceptibility ..
  79. pmc IL-10 production differentially influences the magnitude, quality, and protective capacity of Th1 responses depending on the vaccine platform
    Patricia A Darrah
    Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 207:1421-33. 2010
    ..leishmanial proteins (MML-ADV) elicited a limited proportion of multifunctional IFN-gamma(+)IL-2(+)TNF(+) Th1 cells, a high frequency of IL-10-producing CD4(+) T cells, and did not protect against subsequent challenge...
  80. pmc Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis
    Ilona Kryczek
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    J Immunol 181:4733-41. 2008
    ..We tested stimuli that might account for this activity. Th1 cells and IFN-gamma are increased in psoriatic blood and lesional skin...
  81. ncbi Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses
    Manuel A Gonzalez
    Cellerix SA, Tres Cantos Madrid, Madrid, Spain Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain
    Gastroenterology 136:978-89. 2009
    ..Here, we investigated the potential therapeutic effects of human adipose-derived mesenchymal stem cells (hASCs) in a model of inflammatory bowel disease...
  82. ncbi IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes
    Davide Pennino
    Laboratory of Experimental Immunology, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Via dei Monti di Creta 104, 00167 Rome, Italy
    J Immunol 184:4880-8. 2010
    ..Thus, IL-17 efficiently amplifies the allergic reaction by rendering virtually all of the T lymphocytes recruited at the site of skin inflammation capable to directly contribute to tissue damage...
  83. pmc Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment
    Kiran Nistala
    Rheumatology Unit, University College London Institute of Child Health, London WC1N 1EH, United Kingdom
    Proc Natl Acad Sci U S A 107:14751-6. 2010
    ..to Th17/1 under conditions that mimic the disease site, namely low TGFbeta and high IL-12 levels, whereas Th1 cells cannot convert to Th17...
  84. pmc The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut
    C Wang
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Cancer Center, Bindley Bioscience Center, Purdue University, West Lafayette, Indiana, USA
    Mucosal Immunol 2:173-83. 2009
    ..We conclude that CCR6 regulates Th17 cell migration to the gut and effector T-cell balance/distribution in inflamed intestine...
  85. pmc Increased frequencies of Th22 cells as well as Th17 cells in the peripheral blood of patients with ankylosing spondylitis and rheumatoid arthritis
    Lei Zhang
    Department of Orthopedics, Qilu Hospital, Shandong University, Jinan, China
    PLoS ONE 7:e31000. 2012
    ..So we examined the frequencies of Th22 cells, Th17 cells and Th1 cells in peripheral blood (PB) from patients with AS and patients with RA compared with both healthy controls as well ..
  86. ncbi Immunopathogenesis of infection with the visceralizing Leishmania species
    Mary E Wilson
    Department of Internal Medicine, University of Iowa, The VA Medical Center, Iowa City, IA, USA
    Microb Pathog 38:147-60. 2005
    ..These studies should eventually result in a better understanding of the immunopathogenesis and the spectrum of human leishmaniasis...
  87. ncbi Kinetoplastid membrane protein-11 DNA vaccination induces complete protection against both pentavalent antimonial-sensitive and -resistant strains of Leishmania donovani that correlates with inducible nitric oxide synthase activity and IL-4 generation: ev
    Rajatava Basu
    Department of Immunology, Indian Institute of Chemical Biology, Kolkata
    J Immunol 174:7160-71. 2005
    ..This is the first report of a vaccine conferring protection to both antimony responsive and resistant Leishmania strains reflecting several aspects of clinical visceral leishmaniasis...
  88. pmc Th1-Th17 cells mediate protective adaptive immunity against Staphylococcus aureus and Candida albicans infection in mice
    Lin Lin
    The Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles Medical Center, Torrance, California, USA
    PLoS Pathog 5:e1000703. 2009
    ..aureus and C. albicans from tissues. Thus, vaccine-mediated adaptive immunity can protect against both infections by targeting microbes for destruction by innate effectors...
  89. ncbi Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12
    Edda G Schulz
    Theoretical Biophysics, Institute of Biology, Humboldt Universitat, Invalidenstrasse 42, 10115 Berlin, Germany
    Immunity 30:673-83. 2009
    ..Thus initial polarization and subsequent imprinting of Th1 cells are mediated by interlinked, sequentially acting positive feedback loops of TCR-interferon-gamma-Stat1-T-bet and ..
  90. pmc Immunization with live and dead Chlamydia muridarum induces different levels of protective immunity in a murine genital tract model: correlation with MHC class II peptide presentation and multifunctional Th1 cells
    Hong Yu
    British Columbia Centre for Disease Control, University of British Columbia, Vancouver, British Columbia V5Z 4R4, Canada
    J Immunol 186:3615-21. 2011
    ..muridarum. These insights should prove useful for improving vaccine design for Chlamydia trachomatis...
  91. ncbi IL-13 is a susceptibility factor for Leishmania major infection
    D J Matthews
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    J Immunol 164:1458-62. 2000
    ..Furthermore, using BALB/c mice deficient in the expression of IL-4, IL-13, or both IL-13 and IL-4, we demonstrate that IL-13-deficient mice are resistant to infection and that there is an additive effect of deleting both IL-4 and IL-13...
  92. pmc Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
    D J Berg
    Department of Immunology and Molecular Biology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
    J Clin Invest 98:1010-20. 1996
    ..In 3-mo-old mutants, intestinal lesions were most severe in IL-10-/- 129/SvEv and IL-10-/- BALB/c strains, of intermediate severity in the IL-10-/- 129 x C57BL/6J outbreds, and least severe in the IL-10-/- C57BL/6J strain...
  93. ncbi IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses
    J Magram
    Department of Biotechnology, Roche Institute of Molecular Biology, Nutley, New Jersey 07110, USA
    Immunity 4:471-81. 1996
    ..However, other phenomena associated with Th1 responses and cell-mediated immunity, i.e., IL-2 secretion and CTL generation, were not compromised in the absence of IL-12...
  94. ncbi A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation
    J Das
    Department of Medicine, Pulmonary and Critical Care Section, Yale University School of Medicine, 333 Cedar Street, LCI 105, New Haven, CT 06520, USA
    Nat Immunol 2:45-50. 2001
    The transcription factor GATA-3 is expressed in T helper 2 (TH2) but not TH1 cells and plays a critical role in TH2 differentiation and allergic airway inflammation in vivo...
  95. ncbi CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen
    H L Davis
    Loeb Research Institute, Ottawa Civic Hospital, ON, Canada
    J Immunol 160:870-6. 1998
    ..These studies demonstrate that CpG ODN are promising new immune enhancers for vaccination applications...
  96. pmc Identification of human T cell antigens for the development of vaccines against Mycobacterium tuberculosis
    Sylvie Bertholet
    Infectious Disease Research Institute, Seattle WA 98104, USA
    J Immunol 181:7948-57. 2008
    ..This study identified numerous novel human T cell Ags suitable to be included in subunit vaccines against tuberculosis...
  97. ncbi Endogenous IL-4 is necessary for effective drug therapy against visceral leishmaniasis
    J Alexander
    Department of Immunology, University of Strathclyde, Glasgow, GB
    Eur J Immunol 30:2935-43. 2000
    ..These results demonstrate that IL-4 has an important role in effective anti-leishmanial chemotherapy which seems to be related to modulation of IFN-gamma production...
  98. ncbi Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease
    L Rovedatti
    Institute of Cell and Molecular Science, London School of Medicine and Dentistry, London E1 2AT, UK
    Gut 58:1629-36. 2009
    ..Interleukin 17 (IL17) is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production in inflammatory bowel disease (IBD) are still unclear...
  99. pmc Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis
    Estelle Bettelli
    Center for Neurologic Diseases, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Exp Med 200:79-87. 2004
    ..in the initiation and regulation of experimental autoimmune encephalomyelitis (EAE), a disease initiated by Th1 cells. T-bet-deficient mice immunized with myelin oligodendrocyte glycoprotein (MOG) were resistant to the development ..
  100. pmc T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis
    Robert C Axtell
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA
    Nat Med 16:406-12. 2010
    ..Hence, IFN-beta is proinflammatory in T(H)17-induced EAE. Moreover, a high IL-17F concentration in the serum of people with RRMS is associated with nonresponsiveness to therapy with IFN-beta...
  101. pmc An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
    M G Chiaramonte
    Schistosomiasis Immunology and Pathology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 104:777-85. 1999
    ..Thus, our findings provide evidence that IL-13 inhibitors may be of general therapeutic benefit in preventing damaging tissue fibrosis resulting from Th2-dominated inflammatory responses...

Research Grants75

  1. Regulation of Innate and Adaptive Immunity in Human COPD and Emphysema
    Farrah Kheradmand; Fiscal Year: 2012
    ..In support of this aim, we have found that Th1 cells persist in the lung of former-smokers with emphysema despite years of smoking cessation. Objective 2...
  2. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..To identify small molecules which may be selective for Th17 cells as opposed to Th1 cells, we recently conducted a compound library screen to indentify small molecules that would suppress Th17 cells but ..
  3. Modeling TH17 Cells in Acute GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2010
    ..significant quantities of IFN- suggesting that the production of this cytokine may not be generated solely by Th1 cells. In the current proposal, we will evaluate the function of Th17 cells in GVHD models and determine how they ..
  4. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..In this application, we will study the role of a subset of cells in the immune system called T helper cells to determine if they could be responsible for the destruction of lung in subjects with COPD and emphysema. ..
  5. Chemokine Decoy Receptor for Therapy of Autoimmune Arthritis
    Kanneganti Murthy; Fiscal Year: 2012
    ..Moreover, Ag-specific effector Th1 cells isolated from EAE donors treated in vivo with mR-421 produce substantially less pro-inflammatory cytokines and ..
  6. Chemokine Decoy Receptor: a novel therapy of IBD
    Kanneganti Murthy; Fiscal Year: 2012
    ..Moreover, Ag-specific effector Th1 cells isolated from EAE donors treated in vivo with mR-421 produce substantially less pro-inflammatory cytokines and ..
  7. Galectin-3 in regulation of allergic skin inflammation
    Fu Tong Liu; Fiscal Year: 2013
    ..T cells from galectin-3-deficient mice, we have demonstrated that galectin-3 is an inhibitory regulator in Th1 cells and suppresses the T cell receptor (TCR)-mediated Th1 response by promoting TCR downregulation...
  8. Transplantation tolerance and immune function following mTOR inhibition.
    Jonathan D Powell; Fiscal Year: 2013
    ..demonstrated that rapamycin can promote regulatory T cell (Treg) differentiation of naive T cells and anergy of Th1 cells following T cell activation...
  9. Towards a vaccine against Fasciola hepatica using FhSAP2 as an antigen
    Ana M Espino; Fiscal Year: 2013
    ..results led us to hypothesize that the protection induced by FhSAP2 is mediated by a mechanism linked to CD4+ Th1 cells, which is a new concept in the field of fascioliasis since F...
  10. A translational model of neuro-immune therapy for PTSD in veterans of the OEF/OIF
    Leonardo H Tonelli; Fiscal Year: 2013
    ..TH2 cells and in specific aim #3 we will test the effects of reconstituting RAG2-/- mice with differentiated TH1 cells in behavioral, immunological and neurochemical responses...
  11. Role of interleukin-17 and iNKT cells in COPD
    ABDALA EL KHAL; Fiscal Year: 2010
    ..In contrast to asthma, CD4+ T cells that infiltrate the inflamed lung are mainly Th1 cells. However, recent studies showed that bronchoalveolar fluid lavage (BALF) from patients with COPD have an ..
  12. Modular Subunit Vaccine for Salmonella
    MARC KEVIN JENKINS; Fiscal Year: 2011
    ..infection, uniformly differentiated into [unreadable]multifunctional[unreadable] IFN-γ/TNF-producing Th1 cells, persisted at a high and stable level for hundreds of days, and controlled the infection without disease...
  13. MicroRNA Modulation of Immune Function in Multiple Sclerosis
    Caroline C Whitacre; Fiscal Year: 2012
    ..MiR-29 is therefore positioned to modulate multiple developmental stages in TH1 cells, including effector cytokine production and transcriptional programming...
  14. Role of serum amyloid A in interferon-gamma expression and T helper 1 cell differ
    Rong Lucy He; Fiscal Year: 2013
    ..SAA stimulates T cells to secrete IFN3, a key cytokine directing the differentiation of naove CD4+ T cells into Th1 cells. Based on these compelling preliminary data, we propose to test the central hypothesis that SAA plays an ..
  15. T Cell-Mediated Mechanisms of Autoimmunity in Murine and Human Biliary Atresia
    CARA LYNN MACK; Fiscal Year: 2011
    ..In human BA, the periductal inflammation is composed of Th1 cells and macrophages...
  16. Flexibility and Commitment in Post-Effector Cd4 Lymphocytes
    Mark R Boothby; Fiscal Year: 2013
    ..Production of IFN-? by Th1 cells is central to immunity against many intracellular pathogens, but induction of this gene is blocked in activated ..
  17. Controlling Th2 immunity by tuning CXCL13 dependent DC migration in lymph nodes
    Frances E Lund; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): CD4 T cells, particularly IFN[unreadable]-producing Th1 cells, provide protection to intracellular pathogens like Leishmania major...
  18. CYTOKINE REGULATION IN EXPERIMENTAL ARTHRITIS
    Alison Finnegan; Fiscal Year: 2013
    ..Similar to RA, PGIA is critically dependent on auto reactive T cell activation. In PGIA, activation of Th1 cells and the production of IFN3 are critical for development of severe arthritis...
  19. Exosome-induced innate and antigen-specific immune responses in Type 1 Diabetes
    Yang D Dai; Fiscal Year: 2013
    ..We will use EXO as a vehicle for activating DC and delivering antigens. We anticipate that EXO can upregulate Slc11a1 function in DC and thus promote induction of the disease-causing Th1 cells.
  20. A Novel Therapy for Restricted Induction of Tolerance to Treat Diabetes Mellitus
    Kanneganti Murthy; Fiscal Year: 2013
    ..Ex vivo repolarization of Th1 cells, however, is cumbersome and expensive...
  21. Tim3 and Mycobacterium tuberculosis
    Samuel M Behar; Fiscal Year: 2013
    ..While signaling via Tim3 on TH1 cells has been purported to deliver a negative signal that could reduce unintended tissue inflammation, the ..
  22. The role of CBir1 flagellin-specific Th17 and Th1 effector cells in colitis
    Yingzi Cong; Fiscal Year: 2012
    ..CBir1-specific Th17 and Th1 cells can be isolated from these CBir1 transgenic mice and transfer disease in immunodeficient mice...
  23. Therapeutic Immunoregulation Mediated by TGF-beta-induced iTregs in Autoimmune Ar
    Song Guo Zheng; Fiscal Year: 2013
    ..Interestingly, our recent studies revealed that unlike nTregs, iTregs did not make conversion to Th17 and Th1 cells in the presence of pro-inflammatory cytokines...
  24. P. gingivalis-specific T cells in mice prone and resistant to periodontitis
    Massimo Costalonga; Fiscal Year: 2013
    ..to disease, RgpA- and Kgp-specific CD4+ T helper (Th) cells differentiate into bone destructive IFN-? producing Th1 cells, and into a Th17 phenotype after periodontal bone destruction has been initiated...
  25. Role of Th1 Immune Responses in the Pathogenesis of Hypertensive Kidney Injury
    Steven D Crowley; Fiscal Year: 2013
    ..Whereas Th2 cells regulate antibody responses, Th1 cells secrete IFN-g leading to activation of macrophages and cytotoxic CD8+ T cells to mediate cellular damage...
  26. Role of PGE2 in CNS and peripheral autoimmune disorders
    Doina Ganea; Fiscal Year: 2010
    ..disease, and rheumatoid arthritis, suggest that IL-17 producing T cells (ThlL-17) rather than the IFNg-producing Th1 cells are the most relevant participants in autoimmunity...
  27. Mechanisms underlying T helper suppression by regulatory T cells
    AYANA JORDAN; Fiscal Year: 2009
    ..Subsequently, chromatin immunoprecipitation (ChIP) will be performed on suppressed Th1 cells to determine if activation by NFAT involves direct recruitment of this protein to the promoter regions of T cell ..
  28. ESAT-6 primes dendritic cells with reduced IL-12 and increased IL-23 production
    Buka Samten; Fiscal Year: 2013
    ..in priming T cell responses through production of IL-12 and IL-23, which favor expansion of IFN-g-producing Th1 cells and IL-17-producing Th17 cells, respectively...
  29. Defining modes of helper T cell motility within inflamed tissues
    Michael Glen Overstreet; Fiscal Year: 2012
    ..b>Th1 cells moved rapidly with amoeboid-like motility while Th2 cells crawled with mesenchymal-like motility...
  30. REGULATION OF NEONATAL IMMUNITY
    Habib Zaghouani; Fiscal Year: 2010
    ..that IL-4 from the Th2 cells utilizes a heteroreceptor comprising IL-4Ra and IL-13Ra1 chains to drive death of Th1 cells and bias neonatal immunity towards Th2 cells...
  31. Defining Adaptive Immune Mechanisms of Insulin Resistance
    Edgar G Engleman; Fiscal Year: 2013
    ..of insulin resistance by overcoming the anti-inflammatory effects of B-1 cells through their activation of VAT Th1 cells and secretion of pathogenic IgG autoantibodies...
  32. Interplay Between Pathogenic and Regulatory T Cells in EAE
    Estelle Bettelli; Fiscal Year: 2012
    ..Abstract T helper (h) 17 cells are a newly described subset of CD4+ T cells which has been implicated, along with Th1 cells in the development of autoimmune diseases such as multiple sclerosis (MS) and its animal model experimental ..
  33. The Role of IL-17 in fungal keratitis
    PATRICIA RENEE TAYLOR; Fiscal Year: 2013
    ..following immunization, which were selectively recruited to the cornea after infection (Th17 cells at 48h, and Th1 cells at 72h)...
  34. Maintenance vs Programming in Th1 Memory Cell Development in P. Chabaudi Malaria
    Robin Stephens; Fiscal Year: 2013
    ..Therefore, our central hypothesis is that Tem subsets maintain a protective cytokine program like committed Th1 cells that is maintained by the inflammation associated with chronic infection...
  35. Regulation of T-cell function and autoimmune inflammation by deubiquitinase CYLD
    Shao Cong Sun; Fiscal Year: 2013
    ..Furthermore, the CYLD-/- mice produce aberrantly high levels of inflammatory Th17 and Th1 cells, coupled with heightened EAE response...
  36. Th1/Th17 Macrophage Interactions in Cutaneous GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2013
    ..Specifically, our group and others have found that Th17 cells in the presence of IL-12 become Th1 cells. These findings provide a new opportunity to reexamine the role of specific T cell subsets in the ..
  37. REGULATION OF AUTOIMMUNITY WITH T CELL RECEPTOR PEPTIDES
    Arthur A Vandenbark; Fiscal Year: 2010
    ..constitutes a distinct peripheral autoregulatory mechanism for limiting inflammatory reactions mediated by Th1 cells directed at tissue-specific antigens such as myelin proteins...
  38. HIV induces Gli Proteins to skew naive CD4+ T cells to Th1 and TGF-b effectors
    Christel H Uittenbogaart; Fiscal Year: 2010
    ..whereby HIV-1 modulates the human Gli transcription factors to skew T-cell differentiation away from antiviral Th1 cells toward immunosuppressive T-cells...
  39. Role of Novel T Cell Costimulatory Pathways in Allograft Rejection and Tolerance
    Mohamed H Sayegh; Fiscal Year: 2011
    ..Furthermore, it is well established that the balance of autoreactive Th1 cells on one hand and regulatory T cells and Th2 cells on the other is critical in determining the outcome of ..
  40. T Cell Tolerance in Neonates
    Habib Zaghouani; Fiscal Year: 2010
    Neonatal tolerance represents an immune response that lacks Th1 cells but displays an indubitable bias towards Th2. This provides an environmental pre-disposition to allergies and infections...
  41. PARP activity in allergic inflammation
    Mark H Kaplan; Fiscal Year: 2012
    ABSTRACT T helper 2 (Th2) cells mediate immunity to parasites and promote allergic disease, while Th1 cells provide immunity to intracellular pathogens and initiate inflammation...
  42. MOG-Specific T Cell Trafficking in the Central Nervous System
    JOAN M GOVERMAN; Fiscal Year: 2012
    ..cord is regulated by the ratio, and not the absolute number or epitope specificity, of myelin-specific Th17 and Th1 cells. Interestingly, MOG97-114 specific T cells also exhibit a higher functional avidity for their antigen compared ..
  43. Pathogenic and Protective T Cells in Toxoplasmosis
    George S Yap; Fiscal Year: 2013
    ..The studies proposed here will provide new insights into how potentially pathogenic Th1 cells are restrained and how protective CD8 T cells are generated and maintained over the long term, specifically with ..
  44. Role of the M1 macrophage response in the progression of chronic kidney disease
    Steven D Crowley; Fiscal Year: 2013
    ..We therefore posit that in the setting of CKD, M1 macrophage responses are amplified by actions of Th1 cells but are inhibited by the activation of AT1 receptors on macrophages...
  45. ??PK mediated melanoma stem cell oncolysis through non-redundant programmed cell
    ARIC G COLUNGA; Fiscal Year: 2011
    ..Delta PK is a particularly promising virotherapy because it elicits Th1 cells, which override the suppressive melanoma milieu and it is tolerated well in humans...
  46. Tr1-Specific Tolerance: a Novel Treatment of Multiple Sclerosis
    Kanneganti Murthy; Fiscal Year: 2012
    ..The durability of this repolarization is shown in adoptive transfer studies wherein Ag-specific effector Th1 cells isolated from murine EAE donors treated in vivo with mR-411 suppress EAE in recipients with active disease...
  47. T cell plasticity in atherosclerosis
    Elena V Galkina; Fiscal Year: 2013
    ..of IFN3+IL-17A+ T cells in Apoe-/- mice indicates that Th17 cells retain plasticity and may cooperate with Th1 cells. We hypothesize that atherosclerotic conditions shift the reciprocal Th17/Treg cell balance towards Th17 cells...
  48. Immune function and mechanism of Tim3 expression and Tim3+ T cells in TB &HIV+TB
    Zheng W Chen; Fiscal Year: 2013
    ..mucin domain-containing molecule 3 (Tim-3) is a membrane protein initially identified as a negative regulator of Th1 cells. However, new studies suggest that Tim-3 expression/ functions in infections appear to be more diverse than ..
  49. Control of chromatin landscapes in effector T cell lineage specifications
    Casey T Weaver; Fiscal Year: 2012
    ..to understand modifications of chromatin structure associated with the mutually exclusive expression of Ifng by Th1 cells, and 114, 115, and 1113 by Th2 cells, a detailed understanding of the interplay of multiple distal regulatory ..
  50. Chemokine receptors and the interferon gamma pathway in Th1 cell trafficking
    Zamaneh Mikhak; Fiscal Year: 2010
    Homing of Th1 cells to sites of Th1 inflammation relies on the interaction of chemokine receptors on Th1 cells with the chemokines secreted at Th1 inflammatory sites...
  51. TRACKING CD4+ MEMORY T CELLS IN VIVO
    MARC KEVIN JENKINS; Fiscal Year: 2013
    ..that acute infection with an attenuated strain of Listeria monocytogenes (LM) generated T-bet+ IFN-3-producing Th1 cells, a novel population of Tbet- cells of unknown function that depended on an unknown signal from B cells, and ..
  52. Novel ways to prevent upper GT infection
    Kathleen A Kelly; Fiscal Year: 2013
    ..be engineered to induce mucosal immunity and be used as a tool to identify key immune triggers which produce Th1 cells that traffic to genital mucosal tissue...
  53. A Comparative Genomics and Transgenic Approach to Regulation of IL-10 Expression.
    Jay H Bream; Fiscal Year: 2013
    ..Donovani infection in Il10-/- mice. This was because;only a small population of hIL-10+Th1 cells (which mediates this phenotype) were induced in hIL10BAC mice...
  54. CXCL16/CXCR6 and Their Roles in Autoimmune Arthritis
    Shuhua Han; Fiscal Year: 2010
    ..The receptor-bearing cells are mainly Th1 cells, display extralymphoid tissue homing potential and are enriched in inflamed synovial fluid of RA patients...
  55. Protective CD4+ T cells
    MARC KEVIN JENKINS; Fiscal Year: 2013
    ..IFN-? producing Th1 cells control the infection within phagocytes at the initial site of infection and prevent it from spreading to other ..
  56. Targeting IL-12/23 p40 Pathways for the Control of GVHD
    Xue Zhong Yu; Fiscal Year: 2013
    ..Classically, Th1 cells are believed to play a critical role in the induction of GVHD;although recently we and others showed that Th17 ..
  57. Stat4 Immunobiology
    Mark H Kaplan; Fiscal Year: 2013
    ..enzymes mediating epigenetic modifications, in the Stat4-dependent programming of genes for expression in Th1 cells. We will examine the role of Stat4 in maintaining Th17 responses and the development of allergic inflammation ..
  58. EGR-2/3 and NAB2 in T Cell Anergy and Activation
    Jonathan D Powell; Fiscal Year: 2013
    ..we will test the hypothesis that mechanistically, Egr-2 and Egr-3 inhibit T cell function and promote anergy in Th1 cells by repressing IL-2 transcription and inducing the upregulation of the E3 ligases...
  59. The Role of Lymphocytes in Diet-Induced Metabolic Disease
    Barbara Nikolajczyk; Fiscal Year: 2012
    ..Importantly, Th17 and Th1 cells are major sources of IL-17 and IFN-[unreadable], respectively, two pro-inflammatory, anti-adipogenic, IR-linked ..
  60. Role of IL-17+ Autoreactive T Cells in Experimental Autoimmune Uveitis (EAU)
    Deming Sun; Fiscal Year: 2011
    ..because of studies showing that induction of many autoimmune diseases is not abolished in the absence of Th1 cells and that autoreactive T cells producing IL-17, but not IFN-?, play an important role in autoimmune diseases...
  61. Regulation of effector CD4 T cell subsets during inflammatory bowel disease
    LAURIE ELLEN HARRINGTON; Fiscal Year: 2013
    ..not appear necessary for disease induction, yet it has been demonstrated that transfer of in vitro- polarized Th1 cells can elicit experimental colitis in mice...
  62. Pathogenic Role of NK Cells During Infection-Induced Toxic Shock
    Nahed Ismail; Fiscal Year: 2012
    ..IFN-gamma producing-CD4+ Th1 cells are critical for the elimination of Ehrlichia;however, these cells undergo suppression and late apoptosis during ..
  63. Immunity to Oral Candidiasis
    SARAH GAFFEN; Fiscal Year: 2009
    ..by secretion of IL-17, IL-17F and IL-22, and are driven to develop by TGF2+IL-6+IL-23 rather than by IL- 12 (Th1 cells) or IL-4 (Th2 cells)...
  64. Innate Immunity in Myocarditis
    Sally A Huber; Fiscal Year: 2010
    ..We have shown that + cells selectively kill CD4+Th2 cells leaving the CD4+Th1 cells intact...
  65. CC Chemokine Secretion to Protect Antigen-Specific CD4 T Cells from HIV
    Catarina E Hioe; Fiscal Year: 2010
    ..While CC chemokine expression has been associated with Th1 responses, not all Th1 cells secrete these chemokines in response to their specific antigens...
  66. INTERLEUKIN 5 GENE EXPRESSION AND LUNG INFLAMMATION
    Anuradha Ray; Fiscal Year: 2000
    ..the activationof IL-5 gene transcription in T helper subtype 2 (Th2) cells, those that prevent its production in Th1 cells and the mechanisms that underlie inhibition of IL-5 gene expression by glucocorticoids are poorly understood...
  67. REGULATION OF DIABETES BY CHEMOKINES
    Linda Bradley; Fiscal Year: 2001
    ..b>Th1 cells which secrete IFN-gamma, TNF-alpha, and LT are associated with pathogenesis leading to destruction of islet beta ..
  68. Immune Tolerance Against Type I Diabetes in Mice
    Habib Zaghouani; Fiscal Year: 2007
    ..Modulation of diabetogenic Th1 cells offers a viable antigen-specific strategy against T1D...
  69. Allergic Rhinitis Augments Bacterial Sinusitis
    Robert Naclerio; Fiscal Year: 2001
    ..Th2 cells recruited during the allergic reaction interferes with the recruitment, development, and activation of Th1 cells that contribute to the suppression of infection and inflammation caused by bacterial infection...
  70. Psychoneuroimmunology of T Cell Activation
    Steve Zalcman; Fiscal Year: 2004
    ..We have preliminary evidence that adoptive transfer of TH1 cells into syngeneic recipients induces a rapid increase in the incidence and intensity of stereotyped behavior...
  71. TH2 CELLS AND CYTOKINES AND ALLOGRAFT TOLERANCE
    Jeffrey Punch; Fiscal Year: 2001
    ..holds that uncommitted TH0 cells are stimulated to differentiate into one of two distinct phenotypes: TH1 cells that respond to IL-12 and secrete primarily IL-2 and IFN gamma, or TH2 cells that secrete primarily IL-4, IL-10, ..
  72. Immune Tolerance in the Newborn Mouse
    Habib Zaghouani; Fiscal Year: 2006
    ..We now know that the neonatal immune response usually lacks Th1 cells but displays an indubitable bias towards Th2...
  73. SUPPRESSION OF CNS AUTOIMMUNE DISEASE BY TH2 CELLS
    Stephen Stohlman; Fiscal Year: 2005
    ..Although activated Th1 cells access the CNS, little is known concerning recruitment and/or retention of Tr cells at the site of autoimmunity...
  74. REGULATION OF IL 12 IN MUCOSAL IMMUNITY AND IBD
    Scott Plevy; Fiscal Year: 1999
    ..In autoimmune disorders, Th1 cells may mediate tissue injury...
  75. Control T helper (Th1) cell homing
    GEOFFREY KANSAS; Fiscal Year: 2006
    ..on endothelium, and expression of these carbohydrate ligands is essential for recruitment of these inflammatory Th1 cells to sites of inflammation...