cd4 positive t lymphocytes

Summary

Summary: A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.

Top Publications

  1. ncbi Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    Jason D Fontenot
    Howard Hughes Medical Institute, Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195, USA
    Nat Immunol 4:330-6. 2003
  2. pmc A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    Heon Park
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1133-41. 2005
  3. ncbi PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    Cheryl L Day
    HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban 4013, South Africa
    Nature 443:350-4. 2006
  4. pmc Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    Spencer C Liang
    Wyeth Research, Cambridge, MA 02140, USA
    J Exp Med 203:2271-9. 2006
  5. ncbi Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
  6. pmc CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Dr, Room 3509, Bethesda, MD 20892, USA
    J Exp Med 200:749-59. 2004
  7. ncbi IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
    Shabaana A Khader
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Nat Immunol 8:369-77. 2007
  8. ncbi Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
    Janet D Siliciano
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA
    Nat Med 9:727-8. 2003
  9. ncbi HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    Y Feng
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, MD 20892, USA
    Science 272:872-7. 1996
  10. ncbi Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Immunity 17:375-87. 2002

Research Grants

  1. Molecular Phenotyping of NOD Mice
    Ivan C Gerling; Fiscal Year: 2010
  2. Role of Vif in HIV-1 Replication/AIDS
    David Kabat; Fiscal Year: 2001
  3. Sex in Viral Myocarditis
    Sally Huber; Fiscal Year: 2004
  4. Host specific responses in SIV-induced hematosuppression
    Guido Silvestri; Fiscal Year: 2007
  5. Molecular Basis of Suppression of SLE by CD8+ Ti Cells
    Ram Singh; Fiscal Year: 2008
  6. Sex in Myocarditis
    Sally Huber; Fiscal Year: 2008
  7. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2002
  8. CHEMOIMMUNOTHERAPY FOR BREAST CANCER TREATMENT
    Leisha Emens; Fiscal Year: 2006
  9. Studies of the HIV-associated cell cycle disease
    Guido Silvestri; Fiscal Year: 2006
  10. Targeting Brain Macrophages by a novel lentiviral vector
    Yuntao Wu; Fiscal Year: 2006

Detail Information

Publications265 found, 100 shown here

  1. ncbi Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    Jason D Fontenot
    Howard Hughes Medical Institute, Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195, USA
    Nat Immunol 4:330-6. 2003
    ..Furthermore, ectopic expression of Foxp3 confers suppressor function on peripheral CD4+CD25- T cells. Thus, Foxp3 is a critical regulator of CD4+CD25+ regulatory T cell development and function...
  2. pmc A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    Heon Park
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1133-41. 2005
    ..Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation...
  3. ncbi PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    Cheryl L Day
    HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban 4013, South Africa
    Nature 443:350-4. 2006
    ..Moreover, this pathway of reversible T-cell impairment provides a potential target for enhancing the function of exhausted T cells in chronic HIV infection...
  4. pmc Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    Spencer C Liang
    Wyeth Research, Cambridge, MA 02140, USA
    J Exp Med 203:2271-9. 2006
    ..Collectively, we have identified IL-22 as a new cytokine expressed by Th17 cells that synergizes with IL-17A or IL-17F to regulate genes associated with skin innate immunity...
  5. ncbi Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
    ..Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells...
  6. pmc CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Dr, Room 3509, Bethesda, MD 20892, USA
    J Exp Med 200:749-59. 2004
    ....
  7. ncbi IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
    Shabaana A Khader
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Nat Immunol 8:369-77. 2007
    ....
  8. ncbi Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
    Janet D Siliciano
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA
    Nat Med 9:727-8. 2003
    ..Here we show that even in treated patients who have had no detectable viremia for as long as 7 years, the reservoir decays so slowly (t(1/2) = 44 months) that eradication is unlikely...
  9. ncbi HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    Y Feng
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, MD 20892, USA
    Science 272:872-7. 1996
    ..Fusin messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Fusin acted preferentially for T cell line-tropic isolates, in comparison to its activity with macrophagetropic HIV-1 isolates...
  10. ncbi Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Immunity 17:375-87. 2002
    ..Our findings indicate that IL-17 plays an important role in activating T cells in allergen-specific T cell-mediated immune responses...
  11. pmc Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:13193-7. 1997
    ..In addition, the presence of unintegrated HIV-1 DNA in infected resting CD4+ T cells from patients receiving HAART, even those with undetectable plasma viremia, suggests persistent active virus replication in vivo...
  12. ncbi Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load
    Steven G Deeks
    San Francisco General Hospital, 995 Potrero Ave, San Francisco, CA 94110, USA
    Blood 104:942-7. 2004
    ..These data indicate that immunologic activation set point is established early in HIV infection, and that this set point determines the rate at which CD4+ T cells are lost over time...
  13. pmc Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    T Takahashi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Exp Med 192:303-10. 2000
    ..This unique function of CTLA-4 could be exploited to potentiate T cell-mediated immunoregulation, and thereby to induce immunologic tolerance or to control autoimmunity...
  14. pmc HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
    Asier Saez-Cirion
    Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 75725 Paris, France
    Proc Natl Acad Sci U S A 104:6776-81. 2007
    ..This constitutive antiviral capacity of CD8(+) T cells could account for the control of viral replication in HIC...
  15. pmc Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    Cheng Ming Sun
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:1775-85. 2007
    ..Together, these data demonstrate that the intestinal immune system has evolved a self-contained strategy to promote T reg cell neoconversion...
  16. pmc IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    Claire L Langrish
    Discovery Research, DNAX Research Inc, Palo Alto, CA 94304, USA
    J Exp Med 201:233-40. 2005
    ..Using passive transfer studies, we confirm that these IL-23-dependent CD4(+) T cells are highly pathogenic and essential for the establishment of organ-specific inflammation associated with central nervous system autoimmunity...
  17. pmc CD4 T cells: fates, functions, and faults
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 112:1557-69. 2008
    ....
  18. ncbi HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
    T Dragic
    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York 10016, USA
    Nature 381:667-73. 1996
    ..CC-CKR-5 is a second receptor for NSI primary viruses...
  19. ncbi Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    S Sakaguchi
    Precursory Research for Embryonic Science and Technology PRESTO, Research and Development Corporation of Japan JRDC, Tsukuba Life Science Center
    J Immunol 155:1151-64. 1995
    ..Abnormality of this T cell-mediated mechanism of peripheral tolerance can be a possible cause of various autoimmune diseases...
  20. ncbi IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
    Yutaka Komiyama
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Immunol 177:566-73. 2006
    ..These observations indicate that IL-17 rather than IFN-gamma plays a crucial role in the development of EAE...
  21. ncbi Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    Jun Shimizu
    Department of Immunopathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Nat Immunol 3:135-42. 2002
    ..Thus, GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells and could be a suitable molecular target for preventing or treating autoimmune disease...
  22. ncbi TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    Marc Veldhoen
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Immunity 24:179-89. 2006
    ..Our data indicate that, in the presence of IL-6, TGFbeta1 subverts Th1 and Th2 differentiation for the generation of IL-17-producing T cells...
  23. ncbi HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors
    Stephen A Migueles
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Nat Immunol 3:1061-8. 2002
    ..In addition, the relative absence of these functions in progressors may represent a mechanism by which HIV avoids immunological control...
  24. ncbi Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells
    Jun Wang
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 37:129-38. 2007
    ..These data indicate that expression of endogenous FOXP3, in humans, is not sufficient to induce regulatory T cell activity or to identify T(reg) cells...
  25. pmc Tumor-specific Th17-polarized cells eradicate large established melanoma
    Pawel Muranski
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Mark O Hatfield Clinical Research Center, Bethesda, MD 20892, USA
    Blood 112:362-73. 2008
    ..This principle should be considered in designing clinical trials involving adoptive transfer-based immunotherapy of human malignancies...
  26. pmc HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells
    Alyson Yoder
    Department of Molecular and Microbiology, George Mason University, Manassas, VA 20110, USA
    Cell 134:782-92. 2008
    ..Conversely, induction of active cofilin greatly facilitates it. These findings shed light on viral exploitation of cellular machinery in resting T cells, where chemokine receptor signaling becomes obligatory...
  27. ncbi Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
    H Pircher
    Department of Experimental Pathology, University Hospital, Zurich, Switzerland
    Nature 342:559-61. 1989
    ..Thus the same transgenic TCR-expressing T cells may be tolerized at different stages of their maturation and at different locations in the thymus depending on the antigen involved...
  28. ncbi A microbial symbiosis factor prevents intestinal inflammatory disease
    Sarkis K Mazmanian
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nature 453:620-5. 2008
    ..Harnessing the immunomodulatory capacity of symbiosis factors such as PSA might potentially provide therapeutics for human inflammatory disorders on the basis of entirely novel biological principles...
  29. ncbi Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
    C S Hsieh
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
    Science 260:547-9. 1993
    ..Therefore, this regulatory pathway may have evolved to enable innate immune cells, through interactions with microbial pathogens, to direct development of specific immunity toward the appropriate TH phenotype...
  30. pmc Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge
    Scott G Hansen
    Vaccine and Gene Therapy Institute, Department of Molecular Microbiology, and the Oregon National Primate Research Center, Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, Oregon 97006, USA
    Nat Med 15:293-9. 2009
    ..These data suggest a new paradigm for AIDS vaccine development--vaccines capable of generating and maintaining HIV-specific TEM cells might decrease the incidence of HIV acquisition after sexual exposure...
  31. pmc HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse
    Clare Jolly
    The Sir William Dunn School of Pathology, University of Oxford, UK
    J Exp Med 199:283-93. 2004
    ..We propose that receptor engagement by Env directs the rapid, actin-dependent recruitment of HIV receptors and adhesion molecules to the interface, resulting in a stable adhesive junction across which HIV infects the target cell...
  32. ncbi Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP
    Vassili Soumelis
    DNAX, 901 California Avenue, Palo Alto, CA 94304, USA
    Nat Immunol 3:673-80. 2002
    ..TSLP expression was associated with Langerhans cell migration and activation in situ. These findings shed new light on the function of human TSLP and the role played by epithelial cells and DCs in initiating allergic inflammation...
  33. ncbi T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy
    Peter W Hunt
    Positive Health Program, San Francisco General Hospital, and San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Infect Dis 187:1534-43. 2003
    ..Interventions that directly target T cell activation or the determinants of activation may prove to be useful adjuvants to antiretroviral therapy...
  34. ncbi T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells
    Maryam Afkarian
    Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, Box 8118, 660 S Euclid Ave, St Louis, MO 63110, USA
    Nat Immunol 3:549-57. 2002
    ..Thus, T-bet is induced by IFN-gamma and STAT1 signaling during T cell activation. In addition, T-bet mediates STAT1-dependent processes of T(H)1 development, including the induction of IL-12Rbeta2...
  35. ncbi DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:587-97. 2000
    ..We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells...
  36. ncbi A critical role for IL-21 in regulating immunoglobulin production
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Science 298:1630-4. 2002
    ..This suggests that these gammac-dependent cytokines may be those whose inactivation is primarily responsible for the B cell defect in humans with XSCID...
  37. pmc Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:8869-73. 1998
    ....
  38. pmc Interleukin-10 determines viral clearance or persistence in vivo
    David G Brooks
    Viral Immunobiology Laboratory, Molecular and Integrative Neuroscience Department, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 12:1301-9. 2006
    ..Thus, we identify a single molecule that directly induces immunosuppression leading to viral persistence and demonstrate that a therapy to neutralize IL-10 results in T-cell recovery and the prevention of viral persistence...
  39. pmc Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    D Breitfeld
    Molecular Tumor and Immunogenetics, Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    J Exp Med 192:1545-52. 2000
    ..Based on the characteristic localization within secondary lymphoid organs, we suggest to term these cells "follicular B helper T cells" (T(FH))...
  40. ncbi Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    Susanne J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 295:338-42. 2002
    ..This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage...
  41. pmc Th17 cells in human disease
    Laura A Tesmer
    Department of Internal Medicine, Division of Rheumatology, Rheumatic Disease Core Center, University of Michigan, Ann Arbor, MI 48109 5358, USA
    Immunol Rev 223:87-113. 2008
    ....
  42. pmc The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure
    Y Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4 Rm 126, Center Dr MSC 0425, Bethesda, MD 20892, USA
    J Exp Med 194:1497-506. 2001
    ....
  43. pmc Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
    Gang Wei
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:155-67. 2009
    ..Our data suggest an epigenetic mechanism underlying the specificity and plasticity of effector and regulatory T cells and also provide a framework for understanding complexity of CD4(+) T helper cell differentiation...
  44. ncbi IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells
    Stefan Pflanz
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 16:779-90. 2002
    ..It also strongly synergizes with IL-12 to trigger IFN-gamma production of naive CD4(+) T cells. IL-27 mediates its biologic effects through the orphan cytokine receptor WSX-1/TCCR...
  45. pmc Phenotypic and functional features of human Th17 cells
    Francesco Annunziato
    Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders DENOThe, University of Florence, Florence 50134, Italy
    J Exp Med 204:1849-61. 2007
    ....
  46. pmc Determinants of viral clearance and persistence during acute hepatitis C virus infection
    R Thimme
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    J Exp Med 194:1395-406. 2001
    ....
  47. ncbi Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells
    Sammy Bedoui
    The Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    Nat Immunol 10:488-95. 2009
    ..This indicates CD103(+) DCs are the main migratory subtype able to cross-present viral and self antigens, which identifies another level of specialization for skin DCs...
  48. ncbi Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
    B Autran
    Laboratoire d Immunologie Cellulaire, URA CNRS 625, Hopital Pitie Salpetriere, 47 83 boulevard de l Hopital, Paris, France
    Science 277:112-6. 1997
    ..Thus, decreasing the HIV load can reverse HIV-driven activation and CD4(+) T cell defects in advanced HIV-infected patients...
  49. ncbi Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer
    E Y Woo
    Department of Surgery, Abramson Family Cancer Research Institute, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 61:4766-72. 2001
    ..These observations provide evidence for the contribution of regulatory T cells to immune dysfunction in cancer patients...
  50. pmc Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes
    Yefei Han
    Department of Medicine, Ross 1049, School of Medicine, Johns Hopkins University, 720 Rutland Ave, Baltimore, MD 21205, USA
    J Virol 78:6122-33. 2004
    ..Taken together, these results demonstrate that HIV-1 genomes reside within actively transcribed host genes in resting CD4+ T cells in vivo...
  51. pmc Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    K Nakamura
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 194:629-44. 2001
    ..This, plus the fact that we could find no evidence that a soluble factor mediates suppression, strongly suggests that CD4(+)CD25(+) T cells exert immunosuppression by a cell-cell interaction involving cell surface TGF-beta1...
  52. ncbi Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction
    Daniel E Kaufmann
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 8:1246-54. 2007
    ..These data, indicating a reversible immunoregulatory pathway selectively associated with CD4(+) T cell dysfunction, provide a potential target for immunotherapy in HIV-infected patients...
  53. pmc Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells
    Sayuri Yamazaki
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 198:235-47. 2003
    ..The capacity to expand CD25+ CD4+ T cells provides DCs with an additional mechanism to regulate autoimmunity and other immune responses...
  54. ncbi IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection
    Euan Lockhart
    Department of Molecular Genetics and Biochemistry, Biomedical Science Tower, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 177:4662-9. 2006
    ..tuberculosis-infected dendritic cells. IL-23 is present in the lungs early in infection and the IL-17-producing cells, such as gammadelta T cells, may represent a central innate protective response to pulmonary infection...
  55. pmc Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract
    Saurabh Mehandru
    Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, 7th Fl, New York, NY 10016, USA
    J Exp Med 200:761-70. 2004
    ..Given the importance of the mucosal compartment in HIV-1 pathogenesis, further study to elucidate the significance of the changes observed here is critical...
  56. pmc Preferential replication of HIV-1 in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro
    C A Spina
    The Veterans Affairs Medical Center, San Diego, California 92161, USA
    J Clin Invest 99:1774-85. 1997
    ..Our results indicate that HIV replication is enhanced selectively in CD45RO memory phenotype cells through the probable contribution of specialized cellular factors which are produced during CD3-initiated signal transduction...
  57. ncbi CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
    Yasmine Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 420:502-7. 2002
    ....
  58. ncbi Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses
    Kathryn E Foulds
    Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 168:1528-32. 2002
    ..Together, these results suggest that CD4 and CD8 T cells are programmed to undergo limited and extensive proliferation, respectively, to suit their function as regulator and effector cells...
  59. ncbi Persistent immune activation in HIV-1 infection is associated with progression to AIDS
    Mette D Hazenberg
    Department of Clinical Viro Immunology, Sanquin Research at CLB, Tropical Medicine and AIDS, Amsterdam, The Netherlands
    AIDS 17:1881-8. 2003
    ..HIV-1 infection is characterized by chronic generalized CD8 and CD4 T cell hyperactivation, the biological effect of which is not understood...
  60. pmc Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens
    Einar M Aandahl
    Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, California 94110, USA
    J Virol 78:2454-9. 2004
    ..We propose that chronic viral infections lead to induction of suppressive T(R) cells that inhibit the antiviral immune response...
  61. pmc Molecular characterization of preintegration latency in human immunodeficiency virus type 1 infection
    Theodore C Pierson
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 76:8518-31. 2002
    ..Our results demonstrate that the preintegration state is labile and decays rapidly (half-life = 1 day) following the entry of HIV-1 into a resting T cell, with significant decay occurring during the slow process of reverse transcription...
  62. pmc IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART
    Feng Xiang Wang
    Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Clin Invest 115:128-37. 2005
    ....
  63. ncbi The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality
    Patricia A Taylor
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, Minneapolis 55455, USA
    Blood 99:3493-9. 2002
    ..CD4(+)CD25(+) cells warrant consideration as an exciting new modality of cellular therapy for the inhibition of undesirable autologous and allogeneic responses...
  64. ncbi OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells
    P R Rogers
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunity 15:445-55. 2001
    ..Moreover, retroviral transduction of OX40-/- T cells with Bcl-xL or Bcl-2 reverses their survival defect. Thus, a temporal relationship exists between CD28 and OX40, with OX40 being a critical regulator of antigen-driven T cell survival...
  65. ncbi CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation
    Ivan Zanoni
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    Nature 460:264-8. 2009
    ....
  66. ncbi Primary antitumor immune response mediated by CD4+ T cells
    Alexandre Corthay
    Institute of Immunology, University of Oslo, Rikshospitalet and Rikshospitalet University Hospital, 0027 Oslo, Norway
    Immunity 22:371-83. 2005
    ..These data indicate a mechanism for immunosurveillance of MHC-II-negative cancer cells by tumor-specific CD4+ T cells through collaboration with macrophages...
  67. ncbi Endogenous MHC class II processing of a viral nuclear antigen after autophagy
    Casper Paludan
    Laboratory of Viral Immunobiology, Rockefeller University, New York, NY 10021, USA
    Science 307:593-6. 2005
    ..Thus, lysosomal processing after autophagy may contribute to MHC class II-restricted surveillance of long-lived endogenous antigens including nuclear proteins relevant to disease...
  68. pmc In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination
    Laura C Bonifaz
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 199:815-24. 2004
    ....
  69. ncbi Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses
    Shimon Sakaguchi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Annu Rev Immunol 22:531-62. 2004
    ....
  70. ncbi Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection
    Joseph J Mattapallil
    Immunotechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA
    Nature 434:1093-7. 2005
    ..Our findings point to the importance of reducing the cell-associated viral load during acute infection through therapeutic or vaccination strategies...
  71. ncbi Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Blood 105:4743-8. 2005
    ..Based on this new mode of action, rapamycin can be used to expand CD4(+)CD25(+)FoxP3(+) Tr cells for ex vivo cellular therapy in T-cell-mediated diseases...
  72. ncbi Organ-specific disease provoked by systemic autoimmunity
    V Kouskoff
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Illkirch, France
    Cell 87:811-22. 1996
    ..We suggest that human RA develops by an analogous mechanism...
  73. pmc Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor
    Lorenzo Cosmi
    Department of Internal Medicine and DENOTHE Center, University of Florence, Florence 50134, Italy
    J Exp Med 205:1903-16. 2008
    ..These findings implicate CD161 as a novel surface marker for human Th17 cells and demonstrate the exclusive origin of these cells from a CD161(+)CD4(+) T cell progenitor...
  74. ncbi CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major
    Yasmine Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, and Dermatology Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:3992-4000. 2002
    ..The low dose, intradermal challenge model reveals that CD8(+) T cells play an essential role in both pathogenesis of and immunity to primary infection with L. major in the skin...
  75. ncbi Regulatory T cell lineage specification by the forkhead transcription factor foxp3
    Jason D Fontenot
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Immunity 22:329-41. 2005
    ..Analysis of Foxp3 expression during thymic development suggests that this mechanism is not hard-wired but is dependent on TCR/MHC ligand interactions...
  76. pmc IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation
    Shlomo Z Ben-Sasson
    Laboratory of Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Proc Natl Acad Sci U S A 106:7119-24. 2009
    ..These results indicate that IL-1beta signaling in T cells markedly induces robust and durable primary and secondary CD4 responses...
  77. ncbi Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy
    Giulia Marchetti
    Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy
    AIDS 22:2035-8. 2008
    ..These data provide novel insight into INRs pathogenesis, since they correlate augmented systemic translocation of microbial bioproducts with T-cell hyperactivation...
  78. pmc Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 188:83-91. 1998
    ....
  79. ncbi Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance
    Alberto Sanchez-Fueyo
    Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Immunol 4:1093-101. 2003
    ..Our data indicate that the Tim-3 pathway provides an important mechanism to down-regulate T(H)1-dependent immune responses and to facilitate the development of immunological tolerance...
  80. ncbi Direct access to CD4+ T cells specific for defined antigens according to CD154 expression
    Marco Frentsch
    Clinical Immunology Group, Deutsches Rheuma ForschungsZentrum, Berlin, Germany
    Nat Med 11:1118-24. 2005
    ....
  81. ncbi Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells
    Megan K Levings
    San Rafaele Telethon Institute for Gene Therapy, Via Olgettina 58, Milan, Italy
    Blood 105:1162-9. 2005
    ..Thus, iDCs can drive the differentiation of Tr1 cells and can be used to generate large numbers of alloantigen-specific Tr1 cells for clinical use as a cellular therapy to restore peripheral tolerance...
  82. pmc Depletion of latent HIV-1 infection in vivo: a proof-of-concept study
    Ginger Lehrman
    University of Texas Southwestern Medical Center at Dallas, Department of Medicine, Division of Infectious Diseases, 5323 Harry Hines Boulevard, Dallas, TX 753901, USA
    Lancet 366:549-55. 2005
    ..Since the chromatin remodeling enzyme histone deacetylase 1 (HDAC1) maintains latency of integrated HIV, we tested the ability of the HDAC inhibitor valproic acid to deplete persistent, latent infection in resting CD4+ T cells...
  83. pmc Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection
    Shabaana A Khader
    Trudeau Institute, Inc, Saranac Lake, NY 12983, USA
    J Exp Med 203:1805-15. 2006
    ..These data define a novel and fundamental role for IL-12p40 in the pathogen-induced activation of pulmonary DCs...
  84. ncbi Signals required for programming effector and memory development by CD8+ T cells
    Matthew F Mescher
    Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Immunol Rev 211:81-92. 2006
    ..Thus, in addition to antigen and costimulation, CD8+ T cells require cytokine signals at distinct stages of the response to be programmed for optimal generation of effector and memory populations...
  85. ncbi Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 6:757-61. 2000
    ....
  86. ncbi Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    B Oppmann
    DNAX Research Institute, Palo Alto, CA 94304, USA
    Immunity 13:715-25. 2000
    ..Similar to IL-12, human IL-23 stimulates IFN-gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells...
  87. pmc Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells
    Jens Dannull
    Genitourinary Cancer Immunotherapy Program, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 115:3623-33. 2005
    ..Our findings may have implications in the design of immune-based strategies that may incorporate the Treg depletion strategy to achieve potent antitumor immunity with therapeutic impact...
  88. ncbi An essential role for Scurfin in CD4+CD25+ T regulatory cells
    Roli Khattri
    Celltech R and D Inc, 1631 220th Street SE, Bothell, Washington 98021, USA
    Nat Immunol 4:337-42. 2003
    ..The forced expression of Foxp3 also delays disease in CTLA-4-/- mice, indicating that the Scurfin and CTLA-4 pathways may intersect and providing further insight into the T(R) cell lineage...
  89. ncbi Interleukin-2 is essential for CD4+CD25+ regulatory T cell function
    Maurus de la Rosa
    Deutsches Rheuma ForschungsZentrum Berlin, Berlin, Germany
    Eur J Immunol 34:2480-8. 2004
    ..We propose the parakrine uptake of soluble mediators as a flexible mechanism to adapt Treg activity to the strength of the responder T cell reaction...
  90. pmc HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir
    Tae Wook Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 115:3250-5. 2005
    ..Such events may allow continual replenishment of the CD4+ T cell reservoir and resetting of the half-life of the latently infected, resting CD4+ T cells despite prolonged periods of aviremia...
  91. ncbi The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion
    I Gramaglia
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 165:3043-50. 2000
    ..In this way, OX40 signals promote survival of greater numbers of T cells with time and control the size of the memory T cell pool...
  92. ncbi Life and death in the granuloma: immunopathology of tuberculosis
    Bernadette M Saunders
    Mycobacterial Research Programme, Centenary Institute, Newtown, New South Wales, Australia
    Immunol Cell Biol 85:103-11. 2007
    ..The immunological factors controlling the development and maintenance of the granuloma will be reviewed...
  93. pmc The transcription factor PLZF directs the effector program of the NKT cell lineage
    Adam K Savage
    Howard Hughes Medical Institute, Committee on Immunology, Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Immunity 29:391-403. 2008
    ..We suggest that PLZF is a transcriptional signature of NKT cells that directs their innate-like effector differentiation during thymic development...
  94. ncbi Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    Tyler J Curiel
    Tulane University Health Science Center, New Orleans, Louisiana 70112, USA
    Nat Med 10:942-9. 2004
    ..This specific recruitment of T(reg) cells represents a mechanism by which tumors may foster immune privilege. Thus, blocking T(reg) cell migration or function may help to defeat human cancer...
  95. pmc Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
    Andrew W Sylwester
    Vaccine and Gene Therapy Institute, Department of Pathology, Oregon Health and Science University, Beaverton, 97006, USA
    J Exp Med 202:673-85. 2005
    ..These data provide the first glimpse of the total human T cell response to a complex infectious agent and will provide insight into the rules governing immunodominance and cross-reactivity in complex viral infections of humans...
  96. pmc Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains
    Suresh Cuddapah
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 19:24-32. 2009
    ..Our data indicate that CTCF may play important roles in the barrier activity of insulators, and this study provides a resource for further investigation of the CTCF function in organizing chromatin in the human genome...
  97. pmc Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
    Zhi Chen
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:8137-42. 2006
    ..We conclude that Socs3 is an essential negative regulator of IL-23 signaling, inhibition of which constrains the generation of Th17 differentiation...
  98. ncbi Tuberculosis subunit vaccination provides long-term protective immunity characterized by multifunctional CD4 memory T cells
    Thomas Lindenstrøm
    Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
    J Immunol 182:8047-55. 2009
    ....
  99. pmc A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling
    Vladimir R Ramirez-Carrozzi
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    Cell 138:114-28. 2009
    ..By activating a diverse set of transcription factors, Toll-like receptors induce both classes and others for an optimal response to microbial pathogens...
  100. pmc Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control
    Stephen A Migueles
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 29:1009-21. 2008
    ..They also demonstrate that lytic granule contents of memory cells are a critical determinant of cytotoxicity that must be induced for maximal per-cell killing capacity...
  101. pmc Interleukin-17A mediates acquired immunity to pneumococcal colonization
    Ying Jie Lu
    Department of Medicine, Division of Infectious Diseases, Children s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 4:e1000159. 2008
    ..We conclude that IL-17A mediates pneumococcal immunity in mice and probably in humans; its elicitation in vitro could help in the development of candidate pneumococcal vaccines...

Research Grants79

  1. Molecular Phenotyping of NOD Mice
    Ivan C Gerling; Fiscal Year: 2010
    ..With a better understanding of these processes it will be possible to develop interventions that prevents this disease. ..
  2. Role of Vif in HIV-1 Replication/AIDS
    David Kabat; Fiscal Year: 2001
    ..This work may unveil a novel target for drug development in AIDS. ..
  3. Sex in Viral Myocarditis
    Sally Huber; Fiscal Year: 2004
    ..These studies may provide new insights as to how viruses affect developing host defense responses and how hormones can modulate this initial response. ..
  4. Host specific responses in SIV-induced hematosuppression
    Guido Silvestri; Fiscal Year: 2007
    ..Understanding HIV-induced BM suppression will be key for effective hematologic and immune reconstitution strategies. ..
  5. Molecular Basis of Suppression of SLE by CD8+ Ti Cells
    Ram Singh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. Sex in Myocarditis
    Sally Huber; Fiscal Year: 2008
    ..By understanding the factors controlling virus infection and induction of innate immunity, better mechanism for controlling viral disease should be possible. ..
  7. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2002
    ..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
  8. CHEMOIMMUNOTHERAPY FOR BREAST CANCER TREATMENT
    Leisha Emens; Fiscal Year: 2006
    ..abstract_text> ..
  9. Studies of the HIV-associated cell cycle disease
    Guido Silvestri; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  10. Targeting Brain Macrophages by a novel lentiviral vector
    Yuntao Wu; Fiscal Year: 2006
    ..abstract_text> ..
  11. T reg Cells in Myocarditis
    Sally A Huber; Fiscal Year: 2010
    ..Determine whether the T reg cells are antigen specific (virus), cardiovascular specific (autoimmunity), or non-antigen specific. ..
  12. CDI and Gamma Delta+ in Viral Myocarditis
    Sally Huber; Fiscal Year: 2005
    ..abstract_text> ..
  13. Determine the Transcriptional Activity of Non-integrated HIV-1 DNA
    Yuntao Wu; Fiscal Year: 2008
    ..Additionally, non-integrated viral DNA could serve as clinical markers for disease progression in certain situation. [unreadable] [unreadable] [unreadable]..
  14. AFP-Based Immunotherapy for Hepatocellular Carcinoma
    Antoni Ribas; Fiscal Year: 2006
    ..In summary, I propose a clinically-oriented research program that translates this original work into novel, evidence-based immnunotherapy trials for hepatocellular carcinoma. ..
  15. Organ-specific migration of CD4+CD25+ regulatory T cells
    Chang Kim; Fiscal Year: 2006
    ..These studies have the potential to provide important information on organ or tissue-specific trafficking of CD4+CD25+ suppressor T cells and its impact on immune tolerance. ..
  16. MULTI-EPITOPE MELANOMA PEPTIDE VACCINATION WITH GM-CSF
    Craig Slingluff; Fiscal Year: 2004
    ..abstract_text> ..
  17. Ecto-enzyme CD38: Regulator of dendritic cell migration
    Frances Lund; Fiscal Year: 2006
    ..These experiments will validate whether CD38 antagonists have the potential to be used as immunosuppressive agents that attenuate immune responses by modulating leukocyte trafficking. ..
  18. Modulation of type I diabetes with NKT cells
    Luc Van Kaer; Fiscal Year: 2006
    ..These studies will provide a better understanding of the immunological mechanisms that result in autoimmunity, and may lead to the development of novel agents for treatment of type I diabetes and other autoimmune diseases. ..
  19. HUMAN B CELL DIFFERENTIATION IN A MODEL SYSTEM
    LORI COVEY; Fiscal Year: 2006
    ..Furthermore, results from these proposed experiments should increase our understanding of hyper-IgM syndrome by identifying a novel gene involved in the pathogenesis of this disease. ..
  20. Substrate recognition motif of the HSV-2 UL 13 kinase
    LYNDA MORRISON; Fiscal Year: 2006
    ..Our long-range goal is to use the novel viral targets identified through application of the UL13 recognition motif to elucidate the mechanisms by which UL13 regulates viral replication and pathology. [unreadable] [unreadable]..
  21. DOMINANCE IN T CELL RESPONSES TO SMALLPOX VACCINATION
    Alessandro Sette; Fiscal Year: 2006
    ..These variola virus-derived epitopes would be incorporated in an optimized multi-determinant vaccine construct, inserted in the currently available vaccinia vaccine. ..
  22. NAD and CD38: modulators of inflammation and immunity
    Frances E Lund; Fiscal Year: 2010
    ..Thus, it is one of NIAID's highest priorities (NOT-AI-05-013) that we develop more effective influenza vaccines that are protective against a wide array of different viral serotypes. ..
  23. Role of Mucosal Immunity in Vaccine Protection
    KRISTINA HOWARD; Fiscal Year: 2007
    ..abstract_text> ..
  24. Age-related changes in glutathione synthesis
    NAOMI FUKAGAWA; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  25. Signal Transduction and Cytokine Gene Regulation by Grail
    Chen Dong; Fiscal Year: 2010
    ..These proposed studies will greatly advance our knowledge on Grail function in T cells and give an important insight into T cell signal transduction and gene regulation programs in immune responses. ..
  26. Norovirus Infection of Dendritic Cells and Macrophages
    Herbert W Virgin; Fiscal Year: 2010
    ..The proposed studies will provide fundamental information about the binding, entry, and uncoating of a very important genus of viruses that incudes many human pathogens. ..
  27. T cell Function in Murine Model of Multiple Sclerosis
    Moses Rodriguez; Fiscal Year: 2010
    ..The findings are expected to provide new insights into the pathogenesis of axonal and neuronal injury in demyelinating disorders such as multiple sclerosis. ..
  28. CSF & Lymphocyte Dynamics in HIV Infection
    Richard W Price; Fiscal Year: 2010
    ..Beyond its immediate implications for prevention, diagnosis and treatment of Neuro-AIDS, it bears on the understanding other immune, inflammatory and degenerative neurological diseases. ..
  29. Ikaros and Mi-2 beta interactions in early lymphoid development
    Katia Georgopoulos; Fiscal Year: 2008
    ..Implementation of regulatory circuits deduced from these studies may allow us to generate clinically useful protocols to manipulate HSC and progenitor cells in a highly controlled fashion. ..
  30. Genetic and Immunological Impact of the HRES-1/Rab4 Locus in SLE
    Andras Perl; Fiscal Year: 2008
    ..Under Specific Aim 3, we will test the hypothesis that the HindIIIG653C allele, alone or in combination with other genetic factors of lupus-associated haplotypes, enhances the expression of HRES-1/Rab4. ..
  31. Tec Kinases ltk and RlK in Mast Cell Signaling
    Leslie Berg; Fiscal Year: 2009
    ..abstract_text> ..
  32. ERM and Rho Signal Pathways in T Cell Immune Senescence
    GONZALO GARCIA; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  33. Memory CD4 T cell-mediated immunopathology in influenza infection
    DONNA FARBER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  34. LYSOLIPID PHOSPHATE REGULATION OF LYMPHOCYTE FUNCTIONS
    EDWARD GOETZL; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  35. The role of IL-2 in promoting CD8 memory T cell responsiveness
    Matthew Williams; Fiscal Year: 2008
    ..In this endeavor, we will explore the role of the growth factor interleukin-2 in enhancing the ability of memory cells to respond to a second encounter with a pathogen. [unreadable] [unreadable] [unreadable] [unreadable]..
  36. Mitochondrial Genomics and Peripheral Neuropathy during HIV Therapy
    Todd Hulgan; Fiscal Year: 2008
    ..Results from this study will also advance the field of "mitochondrial medicine", having broad application across other scientific disciplines and for other human diseases. [unreadable] [unreadable] [unreadable]..
  37. CD4+ memory T cell recruitment by cyclophilin
    Michael Bukrinsky; Fiscal Year: 2004
    ..Therefore, the R03 mechanism appears highly appropriate. If proven, this hypothesis will serve as a foundation for a new research program, which might suggest novel approaches to treatment of HIV-1 infection. ..
  38. The role of TNF receptor family in intestinal GVHD
    GERI BROWN; Fiscal Year: 2004
    ..abstract_text> ..
  39. HIV li-Key/Peptide Vaccine
    Minzhen Xu; Fiscal Year: 2002
    ..This entirely synthetic vaccine can be manufactured in a large scale and be given to those at high risk of HIV infection. ..
  40. CYSTEINE PROTEINASES AS LEISHMANIAL VIRULENCE FACTORS
    LAURENCE BUXBAUM; Fiscal Year: 2002
    ..D. and Ph.D. degrees, with thesis research in the GPI anchor of African trypanosomes. He has completed his clinical training in Internal Medicine and a clinical year of Infectious Diseases at the University of Pennsylvania. ..
  41. Novel Approaches to the Assessment of Oral Mucosal Immu*
    Theresa Whiteside; Fiscal Year: 2003
    ..A better understanding of oral immunity in normal and HIV-infected mucosa is important for the development of new antiviral therapies, including oral antiviral vaccines. ..
  42. ANALYSIS OF E7 SPECIFIC T CELLS USING MHC-1GG MOLECULES
    Drew Pardoll; Fiscal Year: 2002
    ....
  43. IL-12 as an Adjuvant for a Melanoma Peptide Vaccine
    Jeffrey Weber; Fiscal Year: 2003
    ..The results of those assays will be used to design randomized phase III trials for resected high risk melanoma and to develop strategies for overcoming antigen-specific unresponsiveness in melanoma patients. ..
  44. ROLE OF CD30: CD153-PATHOGENESIS OF RHEUMATOID ARTHRITIS
    Andrea Cerutti; Fiscal Year: 2003
    ..In addition to elucidating the pathogenesis of RA, the experiments outlined in this application should allow to devise new strategies aimed at reducing the production of pathogenic antibodies, including rheumatoid factors. ..
  45. MOLECULAR GENETICS OF LOW RENIN HYPERTENSION
    Perrin White; Fiscal Year: 2001
    ..The investigators will determine the role of 11-HSD K in the development of essential hypertension, using both linkage and association studies. ..
  46. Search for Infectious Etiology of Wegener's Disease
    Herbert Virgin; Fiscal Year: 2003
    ..The benefits of identifying potential etiologies for Wegener's are great, preliminary data shows that the methods are in hand, and the team assembled is well qualified to undertake the proposed studies. ..
  47. HPV DNA VACCINE FOR CERVICAL PRE NEOPLASIA
    Jeffrey Weber; Fiscal Year: 2003
    ..To insure that spontaneous regression does not account for a portion of the responses, baseline measurements will be followed one month later by a second set of assessments prior to the start of the vaccine. ..
  48. IN VITRO/IN VIVO ACTIVATED DENDRITIC CELLS FOR MELANOMA
    Jeffrey Weber; Fiscal Year: 2003
    ....
  49. XENOGENEIC STEM CELL AND THYMIC REPLACEMENT IN AIDS
    Megan Sykes; Fiscal Year: 2004
    ..These Projects constitute a highly integrated pre-clinical and clinical program aimed at thymic xenotransplantation as an approach to achieving immune reconstitution in the treatment of HIV-infected people. ..
  50. Role of HIV-1 VIF in Assembly of the RT Complex
    Hui Zhang; Fiscal Year: 2004
    ..these focused and interrelating experiments will allow precise analyses of the molecular mechanism(s) of Vif protein in the assembly of RT machinery, and determine the effects of vif gene on HIV-1 pathogenesis in vivo ..
  51. Leukocyte recruitment by cyclophilinc-CD147 interaction
    Michael Bukrinsky; Fiscal Year: 2005
    ..This exploratory proposal is fully consistent with the goals of this PA as it extends our previous discovery toward new directions related to regulation of inflammatory responses. ..
  52. Evaluating Control of HIV Infection by Engineered Virus
    Gisela Garcia Ramos; Fiscal Year: 2005
    ....
  53. Mitochondrial dysfunction in patients with SLE
    Andras Perl; Fiscal Year: 2004
    ..Thus, checkpoints of mitochondrial hyperpolarization could represent novel targets of pharmacological intervention in patients with SLE. ..
  54. HIV-1 ASSOCIATED SUPERANTIGEN
    DAVID POSNETT; Fiscal Year: 2001
    ..Another aim is to investigate whether the SAG enhances CMV infection or reactivation. Finally a potential role of the CMV SAG in enhancing HIV infection will be explored. ..
  55. Mice with Human Dendritic Cells to Test Vaccine Potency
    A Palucka; Fiscal Year: 2004
    ..The experiments proposed here would lay ground for further use of SCID-hu/DCs mice to study other vaccines and demonstrate development of protective immunity upon in vivo rechallenge. ..
  56. RENAL CANCER ANTIGENS RECOGNIZED BY CD4 T CELLS
    Drew Pardoll; Fiscal Year: 2001
    ....
  57. NEUROIMMUNOLOGY OF AED IN OCULAR HSV-1 INFECTION
    Daniel Carr; Fiscal Year: 2001
    ..abstract_text> ..
  58. INTEGRIN CD103-ROLE IN TH2 PULMONARY IMMUNE RESPONSES
    Manuela Cernadas; Fiscal Year: 2004
    ..These studies may provide significant insights into the role of integrin alphaEbeta7 in T helper cell differentiation and dendritic cell biology. ..
  59. DESIGN OF NOVEL IMMUNOGENS AND ADJUVANTS FOR HIV VACCINE
    Barton Haynes; Fiscal Year: 2003
    ..abstract_text> ..
  60. OCULAR IMMUNOPATHOLOGY IN AUTOIMMUNE MODELS
    DOUGLAS JABS; Fiscal Year: 2001
    ....
  61. Animal Model for SIV Infection Control
    Ivona Pandrea; Fiscal Year: 2010
    ..Deciphering the mechanisms of viral control in this new model may significantly contribute to our understanding of HIV pathogenesis and design of new approaches for controlling HIV infection. ..
  62. GENERATION OF THOMSEN-FREIDENREICH-SPECIFIC T CELLS
    Alessandra Franco; Fiscal Year: 2002
    ..Two strategies will be compared: 1) passive immunotherapy by T cell transfer with selected T cell clones; and 2) active vaccination with the glycopeptides and glycolipids to generate a TF-specific T cell response. ..
  63. Targeted Molecular Therapeutics for Melanoma: CCI-779 and Bevacizumab
    Craig Slingluff; Fiscal Year: 2008
    ..The following proposal is a clinical trial to evaluate the effects of bevacizumab and CCI-779, which interfere with vascularization and tumor growth, for the treatment of melanoma. [unreadable] [unreadable] [unreadable]..
  64. CMV RETINITIS AND VIRAL RESISTANCE
    DOUGLAS JABS; Fiscal Year: 2003
    ....
  65. Dendritic Cells and Breast Cancer Immunity
    A Palucka; Fiscal Year: 2004
    ..Overall, this proposal will permit us to demonstrate that efficient breast cancer immunity can be generated and used to reject the tumor thus permitting development of novel treatment modalities in breast cancer. ..
  66. Using Genomics to Understand Autoimmune Diabetes
    Jonathan Katz; Fiscal Year: 2006
    ..Aim 3: To establish the differential gene expression pattern associated with disease progression and resistance in NOD recipients of islet-reactive Th1 and Th2 T cells. ..
  67. MULTI-EPITOPE MELANOMA VACCINES FOR CD4 AND CD8 T-CELLS
    Craig Slingluff; Fiscal Year: 2009
    ....
  68. Modulation of EAE with ligand-activated NKT cells
    Luc Van Kaer; Fiscal Year: 2005
    ..These reagents will permit the selective activation of distinct adaptive immune responses in vivo, which could be exploited for therapeutic intervention in MS and other human autoimmune diseases. ..
  69. CTL-BASED VACCINES FOR THE AIDS VIRUS
    David Watkins; Fiscal Year: 2003
    ..John Altman will synthesize MHC class I tetramers for CTL quantitation and Deborah Fuller will immunize animals using the gene gun. ..
  70. Evaluation of MicroRNA Expression in CD4 T cells in Type 1 Diabetes
    Alberto Pugliese; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  71. ROLE FOR THE ECTOENZYME CD38 IN IMMUNE RESPONSES
    Frances Lund; Fiscal Year: 2003
    ..These experiments will provide a framework for understanding the elusive role of ecto-enzymes such as CD38 in the generation and maintenance of protective immunity. ..
  72. Combinatorial Chemistry for HIV Entry Inhibitors
    THOMAS NORTH; Fiscal Year: 2007
    ..Future plans are to test the drugs and strategies in our SHIV/rhesus macaque models for mucosal membrane transmission and AIDS. ..
  73. Evaluation of MicroRNA Expression in CD4 T cells in Type 1 Diabetes
    Alberto Pugliese; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  74. INHIBITION OF IL4 EXPRESSION IN CELLS RELEVANT TO ASTHMA
    Steve Georas; Fiscal Year: 2002
    ..Second, we will test the hypothesis that YY1 inhibits the IL-4 promoter in a sequence- specific manner. These studies should enhance our understanding of IL-4 gene expression. ..
  75. Mechanisms of SIV Neutralization
    Kelly Cole; Fiscal Year: 2005
    ..These studies will provide a framework to define the role of type-specific and broadly neutralizing antibody in controlling virus infection and disease in the SIV/rhesus macaque model in vivo, a future goal of this laboratory. ..
  76. CNS Viral Dynamics and Cellular Immunity During AIDS
    David Haas; Fiscal Year: 2009
    ..Characterizing these relationships will expand our knowledge regarding key events that lead to AIDS dementia, and may suggest novel approaches to other immunologic or viral-mediated diseases that affect the brain. ..
  77. SIV MODEL FOR MULTIDRUG RESISTANCE TO AIDS THERAPY
    THOMAS NORTH; Fiscal Year: 2002
    ..In addition, they will also evaluate efficacy of combination treatment of 3TC/PMPA, or the triple combination of AZT/3TC/PMPA, and will characterize any resistant mutants that arise following these treatments. ..