t lymphocytes

Summary

Summary: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.

Top Publications

  1. ncbi Interleukin-17 family members and inflammation
    Jay K Kolls
    Division of Pulmonology, Department of Pediatrics, Children s Hospital of Pittsburgh and the University of Pittsburgh, Pittsburgh, PA, USA
    Immunity 21:467-76. 2004
  2. ncbi Identification of a major co-receptor for primary isolates of HIV-1
    H Deng
    Skirball Institute for Biomolecular Medicine, New York University Medical Center, 10016, USA
    Nature 381:661-6. 1996
  3. ncbi Retinoic acid imprints gut-homing specificity on T cells
    Makoto Iwata
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194 8511, Japan
    Immunity 21:527-38. 2004
  4. ncbi miR-181a is an intrinsic modulator of T cell sensitivity and selection
    Qi jing Li
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 129:147-61. 2007
  5. pmc A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    Janine L Coombes
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    J Exp Med 204:1757-64. 2007
  6. ncbi T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    Thorsten R Mempel
    The CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 427:154-9. 2004
  7. ncbi Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    P Waterhouse
    Department of Immunology, University of Toronto, Ontario, Canada
    Science 270:985-8. 1995
  8. doi T-cell quality in memory and protection: implications for vaccine design
    Robert A Seder
    Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 8:247-58. 2008
  9. pmc Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
    D Hawiger
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 194:769-79. 2001
  10. ncbi Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    Y R Zou
    Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York 10016, USA
    Nature 393:595-9. 1998

Detail Information

Publications373 found, 100 shown here

  1. ncbi Interleukin-17 family members and inflammation
    Jay K Kolls
    Division of Pulmonology, Department of Pediatrics, Children s Hospital of Pittsburgh and the University of Pittsburgh, Pittsburgh, PA, USA
    Immunity 21:467-76. 2004
    ..IL-17A is largely produced by activated memory T lymphocytes but stimulates innate immunity and host defense...
  2. ncbi Identification of a major co-receptor for primary isolates of HIV-1
    H Deng
    Skirball Institute for Biomolecular Medicine, New York University Medical Center, 10016, USA
    Nature 381:661-6. 1996
    ..The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1alpha and MIP-1beta...
  3. ncbi Retinoic acid imprints gut-homing specificity on T cells
    Makoto Iwata
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194 8511, Japan
    Immunity 21:527-38. 2004
    ..These findings revealed a novel role for retinoic acid in the imprinting of gut-homing specificity on T cells...
  4. ncbi miR-181a is an intrinsic modulator of T cell sensitivity and selection
    Qi jing Li
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 129:147-61. 2007
    ..Importantly, higher miR-181a expression correlates with greater T cell sensitivity in immature T cells, suggesting that miR-181a acts as an intrinsic antigen sensitivity "rheostat" during T cell development...
  5. pmc A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    Janine L Coombes
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    J Exp Med 204:1757-64. 2007
    ..These results newly identify RA as a cofactor in T reg cell generation, providing a mechanism via which functionally specialized gut-associated lymphoid tissue DCs can extend the repertoire of T reg cells focused on the intestine...
  6. ncbi T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    Thorsten R Mempel
    The CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 427:154-9. 2004
    ....
  7. ncbi Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    P Waterhouse
    Department of Immunology, University of Toronto, Ontario, Canada
    Science 270:985-8. 1995
    ..Thus, CTLA-4 acts as a negative regulator of T cell activation and is vital for the control of lymphocyte homeostasis...
  8. doi T-cell quality in memory and protection: implications for vaccine design
    Robert A Seder
    Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 8:247-58. 2008
    ....
  9. pmc Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
    D Hawiger
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 194:769-79. 2001
    ..We conclude that in the absence of additional stimuli DCs induce transient antigen-specific T cell activation followed by T cell deletion and unresponsiveness...
  10. ncbi Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    Y R Zou
    Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York 10016, USA
    Nature 393:595-9. 1998
    ..These results may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia...
  11. ncbi Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    E A Tivol
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Immunity 3:541-7. 1995
    ..In the absence of CTLA-4, peripheral T cells are activated, can spontaneously proliferate, and may mediate lethal tissue injury...
  12. ncbi Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy
    Emanuela Zappia
    Department of Neurosciences Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genoa, Italy
    Blood 106:1755-61. 2005
    ..These data suggest that the immunoregulatory properties of MSCs effectively interfere with the autoimmune attack in the course of EAE inducing an in vivo state of T-cell unresponsiveness occurring within secondary lymphoid organs...
  13. pmc IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    David Yen
    Department of Discovery Research, Schering Plough Biopharma, Palo Alto, California 94304, USA
    J Clin Invest 116:1310-6. 2006
    ..This pathway may be responsible for chronic intestinal inflammation as well as other chronic autoimmune inflammatory diseases...
  14. ncbi Regulation of immune responses by L-arginine metabolism
    Vincenzo Bronte
    Cancer Center of Veneto Region, Department of Oncological and Surgical Sciences, Padua University, Via Gattamelata 64, Padua, Italy
    Nat Rev Immunol 5:641-54. 2005
    ..This Review article focuses on the relevance of L-arginine metabolism by myeloid cells for immunity under physiological and pathological conditions...
  15. ncbi Mouse and human dendritic cell subtypes
    Ken Shortman
    Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
    Nat Rev Immunol 2:151-61. 2002
    ..Therefore, we must study the dynamics of the DC network in response to microbial invasion. Despite the difficulty of comparing the DC systems of humans and mice, recent work has revealed much common ground...
  16. ncbi Differential antigen processing by dendritic cell subsets in vivo
    Diana Dudziak
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    Science 315:107-11. 2007
    ..This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing...
  17. ncbi PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes
    Z Sun
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Nature 404:402-7. 2000
    ..TCR-initiated NF-kappaB activation was absent from PKC-theta(-/-) mature T lymphocytes, but was intact in thymocytes...
  18. ncbi The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
    H Choe
    Division of Human Retrovirology Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cell 85:1135-48. 1996
    ..The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary HIV-1 isolates...
  19. ncbi A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival
    P P Lee
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    Immunity 15:763-74. 2001
    ..We conclude that Dnmt1 and DNA methylation are required for the proper expression of certain genes that define fate and determine function in T cells...
  20. ncbi Projection of an immunological self shadow within the thymus by the aire protein
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Science 298:1395-401. 2002
    ..These findings highlight the importance of thymically imposed "central" tolerance in controlling autoimmunity...
  21. ncbi The B7-CD28 superfamily
    Arlene H Sharpe
    Immunology Research Division, Department of Pathology, Brigham, and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 2:116-26. 2002
    ..Here, we summarize our current understanding of the new members of the B7 and CD28 families, and discuss their therapeutic potential...
  22. pmc Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells
    M V Dhodapkar
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021, USA
    J Exp Med 193:233-8. 2001
    ..These data demonstrate the feasibility of antigen-specific inhibition of effector T cell function in vivo in humans and urge caution with the use of immature DCs when trying to enhance tumor or microbial immunity...
  23. ncbi Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein
    Ann M Sheehy
    Department of Microbiology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nature 418:646-50. 2002
    ..the late stages of virus production for the suppression of an innate antiviral phenotype that resides in human T lymphocytes. Thus, in the absence of Vif, expression of this phenotype renders progeny virions non-infectious...
  24. pmc The functional network of ion channels in T lymphocytes
    Michael D Cahalan
    Department of Physiology and Biophysics, and the Institute for Immunology, University of California, Irvine, Irvine, CA 92697 4561, USA
    Immunol Rev 231:59-87. 2009
    ....
  25. ncbi TNF/TNFR family members in costimulation of T cell responses
    Tania H Watts
    Department of Immunology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Annu Rev Immunol 23:23-68. 2005
    ..Despite these complexities, stimulation or blockade of TNFR family costimulators shows promise for several therapeutic applications, including cancer, infectious disease, transplantation, and autoimmunity...
  26. pmc Cancer immunotherapy: moving beyond current vaccines
    Steven A Rosenberg
    Surgery Branch of the Center for Cancer Research at the National Cancer Institute, Building 10, Room 2B42, 10 Center Drive, MSC 1502 Bethesda, Maryland 20892 1502, USA
    Nat Med 10:909-15. 2004
    ..6%), and comparable to the results obtained by others. We consider here results in cancer vaccine trials and highlight alternate strategies that mediate cancer regression in preclinical and clinical models...
  27. ncbi Prevention of allogeneic fetal rejection by tryptophan catabolism
    D H Munn
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Science 281:1191-3. 1998
    ..Thus, by catabolizing tryptophan, the mammalian conceptus suppresses T cell activity and defends itself against rejection...
  28. ncbi Age-related changes in lymphocyte development and function
    Phyllis Jean Linton
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Nat Immunol 5:133-9. 2004
    ..This review aims to provide an overview of age-related changes in lymphocyte development and function and discusses current controversies in the field of aging research...
  29. ncbi Development of a human adaptive immune system in cord blood cell-transplanted mice
    Elisabetta Traggiai
    Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
    Science 304:104-7. 2004
    ..This provides a valuable model to study development and function of the human adaptive immune system in vivo...
  30. pmc T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster
    Rajat Varma
    Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Immunity 25:117-27. 2006
    ..Our studies reveal a role for F-actin in TCR signaling beyond microcluster formation...
  31. ncbi OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    Y Y Kong
    Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Nature 397:315-23. 1999
    ..Thus OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo...
  32. ncbi RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
    Y Shinkai
    Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Cell 68:855-67. 1992
    ..Homozygous mutants are viable but fail to produce mature B or T lymphocytes. Very immature lymphoid cells were present in primary lymphoid organs of mutant animals as defined by surface ..
  33. doi An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes
    Graziella Curtale
    Dipartimento di Biotecnologie Cellulari ed Ematologia, Sezione di Genetica Molecolare, Universita di Roma, Rome, Italy
    Blood 115:265-73. 2010
    ..cells and is abundantly expressed in human memory T cells; consistently, miR-146a is induced in human primary T lymphocytes upon T-cell receptor (TCR) stimulation...
  34. pmc Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity
    Mauritius Menges
    Department of Dermatology, University of Erlangen, Erlangen 91052, Germany
    J Exp Med 195:15-21. 2002
    ..In conclusion, this study describes that stimulation by TNF-alpha results in incompletely matured DCs (semi-mature DCs) which induce peptide-specific IL-10-producing T cells in vivo and prevent EAE...
  35. ncbi Foxp3 in control of the regulatory T cell lineage
    Ye Zheng
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 8:457-62. 2007
    ..Here, we review recent advances in our understanding of the Foxp3-dependent molecular and functional program and the role of Foxp3 in regulatory T cell biology...
  36. pmc Increased expression of interleukin 17 in inflammatory bowel disease
    S Fujino
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Gut 52:65-70. 2003
    ..Interleukin (IL) 17 is a cytokine which exerts strong proinflammatory activities. In this study we evaluated changes in IL-17 expression in the inflamed mucosa and in the serum of patients with inflammatory bowel disease (IBD)...
  37. ncbi A critical role for IL-21 in regulating immunoglobulin production
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Science 298:1630-4. 2002
    ..This suggests that these gammac-dependent cytokines may be those whose inactivation is primarily responsible for the B cell defect in humans with XSCID...
  38. ncbi CD40-CD40 ligand
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    J Leukoc Biol 67:2-17. 2000
    ....
  39. ncbi NFAT proteins: key regulators of T-cell development and function
    Fernando Macian
    Albert Einstein College of Medicine, Department of Pathology, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Rev Immunol 5:472-84. 2005
    ..This Review focuses on the recent advances in our understanding of the regulation, mechanism of action and functions of NFAT proteins in T cells...
  40. ncbi Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever
    Juthathip Mongkolsapaya
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK
    Nat Med 9:921-7. 2003
    ....
  41. ncbi CD28/B7 system of T cell costimulation
    D J Lenschow
    Committee on Immunology, Ben May Institute, Chicago, Illinois 60637, USA
    Annu Rev Immunol 14:233-58. 1996
    ..It is our hope and expectation that this review will provoke additional research that will unravel this important, yet complex, signaling pathway...
  42. ncbi Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    Loredana Ruggeri
    Department of Clinical and Experimental Medicine, Section of Hematology and Clinical Immunology, Perugia University School of Medicine, Perugia, Italy
    Science 295:2097-100. 2002
    ..NK cell alloreactivity may thus provide a powerful tool for enhancing the efficacy and safety of allogeneic hematopoietic transplantation...
  43. pmc T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS
    Isaac M Chiu
    Department of Pathology, Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:17913-8. 2008
    ..These results indicate that T cells play an endogenous neuroprotective role in ALS by modulating a beneficial inflammatory response to neuronal injury...
  44. ncbi PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    Y Latchman
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Immunol 2:261-8. 2001
    ..Taken together, these studies show overlapping functions of PD-L1 and PD-L2 and indicate a key role for the PD-L-PD-1 pathway in regulatingT cell responses...
  45. ncbi B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
    H Dong
    Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Nat Med 5:1365-9. 1999
    ..Our studies thus define a previously unknown co-stimulatory molecule that may be involved in the negative regulation of cell-mediated immune responses...
  46. ncbi Plasmacytoid dendritic cells in immunity
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Immunol 5:1219-26. 2004
    ..Here we review recent progress on the characterization of plasmacytoid dendritic cell origin, development, migration and function in immunity and tolerance, as well as their effect on human diseases...
  47. pmc BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
    P Schneider
    Institute of Biochemistry, University of Lausanne, Switzerland
    J Exp Med 189:1747-56. 1999
    ..These results suggest that BAFF plays an important role as costimulator of B cell proliferation and function...
  48. ncbi Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    H Nishimura
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan
    Immunity 11:141-51. 1999
    ..Collectively, it is suggested that PD-1 is involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses...
  49. ncbi The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
    A G Dalgleish
    Nature 312:763-7. 1984
    ..A subset of T lymphocytes positive for the CD4 antigen (also termed T4 antigen), is depleted in AIDS and PGL patients...
  50. ncbi Adaptive immune responses in acute and chronic hepatitis C virus infection
    David G Bowen
    Center for Vaccines and Immunity, Columbus Children s Research Institute, Columbus, Ohio OH 43205, USA
    Nature 436:946-52. 2005
    ....
  51. ncbi Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
    D M Willerford
    Howard Hughes Medical Institute, Department of Pediatrics, Children s Hospital, Boston, Massachusetts 02115, USA
    Immunity 3:521-30. 1995
    ..Thus, IL-2R alpha is essential for regulation of both the size and content of the peripheral lymphoid compartment, probably by influencing the balance between clonal expansion and cell death following lymphocyte activation...
  52. pmc Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
    Yann M Kerdiles
    Molecular Biology Section, Division of Biological Sciences, Department of Cellular and Molecular Medicine, University of California, San Diego, California 92093 0377, USA
    Nat Immunol 10:176-84. 2009
    ..These data suggest that Foxo1 regulates the homeostasis and life span of naive T cells by sensing growth factor availability and regulating homing and survival signals...
  53. ncbi Immune function of microglia
    F Aloisi
    Neurophysiology Unit, Laboratory of Organ and System Pathophysiology, Istituto Superiore di Sanita, Roma, Italy
    Glia 36:165-79. 2001
    ..This article focuses on the signals regulating microglia innate immune functions, the role of microglia in antigen presentation, and their possible involvement in the development of CNS immunopathology...
  54. ncbi Interleukin-10-deficient mice develop chronic enterocolitis
    R Kuhn
    Institute for Genetics, University of Cologne, Federal Republic of Germany
    Cell 75:263-74. 1993
    ..These results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract...
  55. ncbi Expression of programmed death 1 ligands by murine T cells and APC
    Tomohide Yamazaki
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Immunol 169:5538-45. 2002
    ..The inducible expression of PD-1 ligands on both T cells and APCs may suggest new paradigms of PD-1-mediated immune regulation...
  56. ncbi Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
    J Parrish-Novak
    Department of Functional Cloning, ZymoGenetics, Inc, Seattle, Washington 98102, USA
    Nature 408:57-63. 2000
    ....
  57. ncbi Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    Susan R Schwab
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0414, USA
    Science 309:1735-9. 2005
    ..We conclude that lymphocyte egress is mediated by S1P gradients that are established by S1P lyase activity and that the lyase may represent a novel immunosuppressant drug target...
  58. pmc T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
    F Fossiez
    Schering Plough, Laboratory for Immunological Research, Dardilly, France
    J Exp Med 183:2593-603. 1996
    ..These observations suggest that hIL-17 may constitute (a) an early initiator of the T cell-dependent inflammmatory reaction; and (b) an element of the cytokine network that bridges the immune system to hematopoiesis...
  59. ncbi Tolerogenic dendritic cells
    Ralph M Steinman
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021 6399, USA
    Annu Rev Immunol 21:685-711. 2003
    ..We suggest that several clinical situations, including autoimmunity and certain infectious diseases, can be influenced by the antigen-specific tolerogenic role of DCs...
  60. ncbi Transgenic mice with hematopoietic and lymphoid specific expression of Cre
    Jasper de Boer
    Department of Molecular Immunology, National Institute for Medical Research, The Ridgeway, London, GB
    Eur J Immunol 33:314-25. 2003
    ..Both of these Cre-transgenic lines will be useful in generating tissue-specific gene deletions within all the cells of hematopoietic or lymphoid tissues...
  61. ncbi Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration
    T Sasaki
    Amgen Institute, 620 University Avenue, Toronto M5G 2C1, Ontario, Canada
    Science 287:1040-6. 2000
    ..Thus, PI3Kgamma regulates thymocyte development, T cell activation, neutrophil migration, and the oxidative burst...
  62. ncbi Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells
    Alexander Link
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Nat Immunol 8:1255-65. 2007
    Interleukin 7 is essential for the survival of naive T lymphocytes. Despite its importance, its cellular source in the periphery remains poorly defined...
  63. ncbi The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes
    Karl Balabanian
    Unite d Immunologie Virale, Institut Pasteur, 75015 Paris, France
    J Biol Chem 280:35760-6. 2005
    ..We demonstrate that RDC1 is expressed in T lymphocytes and that CXCL12-promoted chemotaxis is inhibited by an anti-RDC1 monoclonal antibody...
  64. ncbi Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
    ..Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells...
  65. ncbi Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
    Emil H Palacios
    Rosalind Russell Medical Research Center for Arthritis, Department of Medicine and The Howard Hughes Medical Institute, University of California, San Francisco 94143 0795, USA
    Oncogene 23:7990-8000. 2004
    ..SFKs are required for each of these TCR-based signals, and Lck seems to be the major contributor...
  66. ncbi Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood
    Yaniv Ziv
    Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel
    Nat Neurosci 9:268-75. 2006
    Neurogenesis is known to take place in the adult brain. This work identifies T lymphocytes and microglia as being important to the maintenance of hippocampal neurogenesis and spatial learning abilities in adulthood...
  67. ncbi Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1
    Michael W Melkus
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Nat Med 12:1316-22. 2006
    ..This represents the first demonstration of long-term systemic human T-cell reconstitution in vivo allowing for the manifestation of the differential response by human DCs to TSST-1...
  68. ncbi CD28-mediated co-stimulation: a quantitative support for TCR signalling
    Oreste Acuto
    Molecular Immunology Unit, Department of Immunology, Institut Pasteur, 25 rue du Dr Roux, Cedex 15, 75724 Paris, France
    Nat Rev Immunol 3:939-51. 2003
  69. ncbi How can immunology contribute to the control of tuberculosis?
    S H Kaufmann
    Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany
    Nat Rev Immunol 1:20-30. 2001
    ..tuberculosis will be vital in the design of a future vaccine...
  70. pmc Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells
    Sayuri Yamazaki
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 198:235-47. 2003
    ..The capacity to expand CD25+ CD4+ T cells provides DCs with an additional mechanism to regulate autoimmunity and other immune responses...
  71. pmc Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells
    Christa Pfeifhofer
    Institute of Medical Biology and Human Genetics, University of Innsbruck, Schoepfstrasse 41, A 6020 Innsbruck, Austria
    J Exp Med 197:1525-35. 2003
    ..Our finding suggests that PKCtheta plays a critical and nonredundant role in T cell receptor-induced NFAT activation...
  72. pmc Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes
    Peter D Arkwright
    University of Manchester, Royal Manchester Children s Hospital, Manchester, United Kingdom
    Cell Res 20:72-88. 2010
    ..Nanotube formation and intercellular exchanges of death signals are defective in T lymphocytes from patients with autoimmune lymphoproliferative syndrome harbouring mutations in the Fas receptor...
  73. ncbi Molecular mechanisms of cellular transformation by HTLV-1 Tax
    Ralph Grassmann
    Institut fur Klinische und Molekulare Virologie, Universitat Erlangen Nurnberg, Schlossgarten 4, Germany
    Oncogene 24:5976-85. 2005
    ..g. p53, DLG). Moreover, Tax silences cellular checkpoints, which guard against DNA structural damage and chromosomal missegregation, thereby favoring the manifestation of a mutator phenotype in cells...
  74. ncbi CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
    R Forster
    Molecular Tumorgenetics and Immunogenetics, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Cell 99:23-33. 1999
    ..Thus, in order to bring together lymphocytes and dendritic cells to form the characteristic microarchitecture of secondary lymphoid organs, CCR7 is required to rapidly initiate an adoptive immune response...
  75. ncbi Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells
    Alma J Nauta
    Laboratory of Experimental Hematology, Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Immunol 177:2080-7. 2006
    ....
  76. ncbi Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?
    Michael Croft
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Nat Rev Immunol 3:609-20. 2003
    ..The roles of these molecules in initiating and sustaining the T-cell response and in promoting long-lived immunity are discussed...
  77. ncbi LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    S Hacein-Bey-Abina
    INSERM Unit 429, Cedex 15, France
    Science 302:415-9. 2003
    ..Thus, retrovirus vector insertion can trigger deregulated premalignant cell proliferation with unexpected frequency, most likely driven by retrovirus enhancer activity on the LMO2 gene promoter...
  78. pmc CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
    Richard V Parry
    Abramson Family Cancer Research Institute, 556 BRB II III, 421 Curie Blvd, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Cell Biol 25:9543-53. 2005
    ..Together, these data suggest that CTLA-4 and PD-1 inhibit T-cell activation through distinct and potentially synergistic mechanisms...
  79. pmc Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB
    V Groh
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 96:6879-84. 1999
    ..These results raise the possibility that an induced expression of MICA/B, by conditions that may be related to tumor homeostasis and growth, could play a role in immune responses against tumors...
  80. pmc B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells
    S Y Tseng
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Exp Med 193:839-46. 2001
    ..These properties of B7-DC may account for some of the unique activity of DCs, such as their ability to initiate potent T helper cell type 1 responses...
  81. ncbi Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients
    J Schmielau
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Cancer Res 61:4756-60. 2001
    ..These findings indicate that granulocytes are activated in advanced cancer patients and that granulocyte-derived H(2)O(2) is the major cause of severe systemic T-cell suppression...
  82. pmc Rho family GTPases and their regulators in lymphocytes
    Victor L J Tybulewicz
    Division of Immune Cell Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Rev Immunol 9:630-44. 2009
    ....
  83. ncbi Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
    Shimon Sakaguchi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Nat Immunol 6:345-52. 2005
    ..They are therefore a good target for designing ways to induce or abrogate immunological tolerance to self and non-self antigens...
  84. pmc Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells
    Jens Dannull
    Genitourinary Cancer Immunotherapy Program, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 115:3623-33. 2005
    ..Our findings may have implications in the design of immune-based strategies that may incorporate the Treg depletion strategy to achieve potent antitumor immunity with therapeutic impact...
  85. ncbi B7-H4, a molecule of the B7 family, negatively regulates T cell immunity
    Gabriel L Sica
    Department of Immunology, Mayo Medical and Graduate Schools, Mayo Clinic, Rochester, MN 55905, USA
    Immunity 18:849-61. 2003
    ..B7-H4 thus may participate in negative regulation of cell-mediated immunity in peripheral tissues...
  86. ncbi RAG-1-deficient mice have no mature B and T lymphocytes
    P Mombaerts
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139
    Cell 68:869-77. 1992
    ..RAG-1-deficient mice have small lymphoid organs that do not contain mature B and T lymphocytes. The arrest of B and T cell differentiation occurs at an early stage and correlates with the inability to ..
  87. ncbi Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
    Lin Zhang
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia 19104, USA
    N Engl J Med 348:203-13. 2003
    ..Although tumor-infiltrating T cells have been documented in ovarian carcinoma, a clear association with clinical outcome has not been established...
  88. ncbi Functional role of type I and type II interferons in antiviral defense
    U Muller
    Institute of Molecular Biology I, University of Zurich, Switzerland
    Science 264:1918-21. 1994
    ..Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant...
  89. ncbi beta-Cell death during progression to diabetes
    D Mathis
    Section on Immunology and Immunogenetics, Joslin Diabetes Centre, One Joslin Place, Boston, Massachusetts 02215, USA
    Nature 414:792-8. 2001
    ..beta-Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes...
  90. ncbi Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1
    J H Brown
    Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138
    Nature 364:33-9. 1993
    ..A dimer of the class II alpha beta heterodimers is seen in the crystal forms of HLA-DR1, suggesting class II HLA dimerization as a mechanism for initiating the cytoplasmic signalling events in T-cell activation...
  91. ncbi CD95's deadly mission in the immune system
    P H Krammer
    Tumorimmunology Program, German Cancer Research Center, Heidelberg, Germany
    Nature 407:789-95. 2000
    ..Gaining an insight into these processes improves our understanding of the pathogenesis of diseases such as cancer, autoimmunity and AIDS, and opens new approaches to rational treatment strategies...
  92. ncbi Cloning of a new cytokine that induces IFN-gamma production by T cells
    H Okamura
    Department of Bacteriology, Hyogo College of Medicine, Nishinomiya, Japan
    Nature 378:88-91. 1995
    ..IGIF may be involved in the development of Th1 cells and also in mechanisms of tissue injury in inflammatory reactions...
  93. ncbi Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
    D K Dalton
    Genentech Inc, South San Francisco, CA 94080
    Science 259:1739-42. 1993
    ..Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system...
  94. pmc Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    K Nakamura
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 194:629-44. 2001
    ..This, plus the fact that we could find no evidence that a soluble factor mediates suppression, strongly suggests that CD4(+)CD25(+) T cells exert immunosuppression by a cell-cell interaction involving cell surface TGF-beta1...
  95. ncbi DNA damage-induced activation of p53 by the checkpoint kinase Chk2
    A Hirao
    The Amgen Institute, Ontario Cancer Institute, and Departments of Medical Biophysics and Immunology, University of Toronto, 620 University Avenue, Suite 706, Toronto, Ontario, M5G 2C1, Canada
    Science 287:1824-7. 2000
    ..Chk2 directly phosphorylated p53 on serine 20, which is known to interfere with Mdm2 binding. This provides a mechanism for increased stability of p53 by prevention of ubiquitination in response to DNA damage...
  96. ncbi IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 33:1205-14. 2003
    ..Together, these results demonstrate a deviation towards a regulatory/suppressor T cell response during SIT and in normal immunity as a key event for the healthy immune response to mucosal antigens...
  97. pmc Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains
    B S Andrews
    J Exp Med 148:1198-215. 1978
    ....
  98. pmc Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis
    Veronika Groh
    Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 100:9452-7. 2003
    ..These results suggest that a profound dysregulation of NKG2D and its MIC ligands may cause autoreactive T cell stimulation, thus promoting the self-perpetuating pathology in RA and possibly other autoimmune diseases...
  99. pmc Tissue expression of PD-L1 mediates peripheral T cell tolerance
    Mary E Keir
    Department of Pathology, Brigham and Women s Hospital and Children s Hospital Boston, MA 02115, USA
    J Exp Med 203:883-95. 2006
    ..These data provide evidence that PD-L1 expression on parenchymal cells rather than hematopoietic cells protects against autoimmune diabetes and point to a novel role for PD-1-PD-L1 interactions in mediating tissue tolerance...
  100. ncbi Reversal of the TCR stop signal by CTLA-4
    Helga Schneider
    Cell Signalling Section, Division of Immunology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
    Science 313:1972-5. 2006
    ..These results suggest a fundamentally different model of reverse stop signaling, by which CTLA-4 modulates the threshold for T cell activation and protects against autoimmunity...
  101. ncbi Inhibition of death receptor signals by cellular FLIP
    M Irmler
    Institute of Biochemistry, Lausanne Branch, University of Lausanne, Switzerland
    Nature 388:190-5. 1997
    ..High levels of FLIP(L) protein are also detectable in melanoma cell lines and malignant melanoma tumours. Thus FLIP may be implicated in tissue homeostasis as an important regulator of apoptosis...

Research Grants74

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  2. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
    ..Inflammatory cell invasion is characterized by invading adventitial and medial dendritic cells, macrophage, T lymphocytes, specifically T helper 1 (TH1) subpopulations, and giant cells, with attendant elastic layer degradation...
  3. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..of NGF/NGF-R in psoriatic disease we will investigate whether injection of NGF and NGF activated autologus T lymphocytes induce psoriasis in nonlesional skin transplant in the SCID mouse-human skin xenograft model...
  4. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..Several studies have shown that strong CD8+ cytotoxic T lymphocytes (CTL) responses may be elicited by infection or vaccine candidates, which may correlate with marginal ..
  5. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ....
  6. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..Monocytes and activated T lymphocytes dominate the early inflammatory infiltrates...
  7. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
    ..Type 2 helper T lymphocytes (Th2) play a critical role in orchestrating allergic airway inflammation...
  8. Induction and maintenance of regulatory T cells
    Mitchell Kronenberg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Regulatory CD4 T lymphocytes (Treg) are critical for the maintenance of self-tolerance...
  9. Cellular Immunity to Category A-C Viruses in Humans
    ROBERT WILLIAM FINBERG; Fiscal Year: 2013
    ..CTRHIB) is a broad-based interdepartmental program to address, as its overall scientific theme, the role of T lymphocytes n the immunopathogenesis of and protection from category A-C viral pathogens in humans...
  10. Present Homologous and Heterologous Antigen with Hepatitis E Virus
    R Holland Cheng; Fiscal Year: 2012
    ....
  11. PATHOPHYSIOLOGY OF THE ENDOTHELIUM
    Francis W Luscinskas; Fiscal Year: 2013
    ..mechanisms by which endothelium selectively regulates recruitment of the IL17- and IFN-y producing subsets of T lymphocytes into tissues...
  12. Regulation of Innate and Adaptive Immunity in Human COPD and Emphysema
    Farrah Kheradmand; Fiscal Year: 2012
    ..lung tissue examined in subjects with emphysema is enriched with T helper type 1 (Th1) cells, CD4+ and CD8+ T lymphocytes that secrete cytokines such as interleukin 2 (IL-2), and interferon gamma (IFN-g)...
  13. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..The long-range goal of our research is to understand the role of -defensins in the innate immune defense against viruses so that novel therapies can be developed from our findings. ..
  14. Molecular Mechanism of Immune Therapy for Bone Marrow Failures
    Pearlie K Epling-Burnette; Fiscal Year: 2013
    ..In patients with these T-cell mediated bone marrow failure syndromes, it is not clear whether the T lymphocytes become activated locally in the bone marrow against specific bone marrow antigens, or within the peripheral ..
  15. Mucosal Memory T Cells at the Vanguard of Human Host Defense
    Donna L Farber; Fiscal Year: 2010
    ..sites by taking a novel, "whole-body" approach to investigate the functional potential and regulation of T lymphocytes in mucosal sites, by analyzing memory T cells in healthy mucosal and lymphoid tissues obtained from individual ..
  16. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..lung tissue examined in subjects with emphysema is enriched with T helper type 1 (Th1) cells, CD4+ and CD8+ T lymphocytes that secrete cytokines such as interleukin 2 (IL-2), and interferon gamma (IFN?)...
  17. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..for the pathogenesis of psoriatic disease because of their memory phenotype and the ability of activated T lymphocytes to induce psoriasis in transplanted nonlesional skin in the SCID mouse-human skin xenograft model...
  18. Identifying underlying mechanisms of intracellular changes in response to caregiv
    MELANIE SARAH FLINT; Fiscal Year: 2013
    ..of its kind to molecularly analyze psychological stress effects on the comprehensive proteome of circulating T lymphocytes in humans...
  19. MUCOSAL DEFENSE MECHANISMS IN SUBSTANCE ABUSE
    David R Brown; Fiscal Year: 2010
    ..Aim 3, we will characterize delta-opioid receptors mediating chemokine-induced chemotaxis of intestinal T lymphocytes, and determine the effects of opioids on neurally-mediated secretory immunoglobulin-A release from intestinal ..
  20. A novel allele influencing HIV infection among injection drug users
    Xiao Fang Yu; Fiscal Year: 2012
    ..APOBEC3 cytidine deaminases such as A3B are highly expressed in human T lymphocytes and macrophages...
  21. CD4+ T cells in Invasive Aspergillosis
    Amariliz Rivera; Fiscal Year: 2012
    ..goals of the studies proposed in this K22 application are centered in understanding and exploiting CD4 T lymphocytes in defense against fungal disease...
  22. Trophoblast MHC-I: Trigger for Immune-Mediated Rejection of Cloned Bovine Fetuses
    Kenneth L White; Fiscal Year: 2011
    ..fetuses, express classical major histocompatibility complex class I (MHC-I) antigens early in pregnancy, (2) T lymphocytes accumulate in the uterine stroma of SCNT recipients, and (3) MHC homozygous SCNT fetuses fare better than MHC ..
  23. Molecular and Cellular Mechanisms of IL-17 Signaling
    Xiaoxia Li; Fiscal Year: 2013
    ..inflammatory diseases, including the initiation stage (activation and expansion of neuroantigen-reactive CD4 T lymphocytes outside of CNS) and effector stage (recruitment and reactivation of neuroantigen-reactive CD4 T lymphocytes ..
  24. Molecular Mechanisms of Ion Channels in T Lymphocytes
    Michael D Cahalan; Fiscal Year: 2013
    ..entry (SOCE) underlies numerous cellular processes throughout the body and initiates signaling cascades in T lymphocytes that cause changes in motility, secretion of cytolytic granules, cytokine release, and cell proliferation...
  25. NFAT Signaling and Down Syndrome
    Gerald R Crabtree; Fiscal Year: 2012
    ..Initially we will determine if samples from DS human fetuses, cord blood hematopoietic stem cells and T lymphocytes have the expected biochemical and genetic features of reduced NFAT activity and reduced target gene activation...
  26. ANGIOTENSINS, PROSTAGLANDINS-ADRENERGIC INTERACTIONS
    Kafait U Malik; Fiscal Year: 2013
    ..cPLA2[unreadable] gene disruption also ameliorates Ang II-induced renal infiltration of macrophages and T lymphocytes, suggesting alterations in hypertension-induced immune system activation...
  27. Ligands and cofactors required for RORgt function in the immune system
    Dan Littman; Fiscal Year: 2013
    ..follicles in the post-natal intestine;and it is required for the differentiation of Th17 cells from naive CD4+ T lymphocytes. Th17 cells have recently been shown to be major mediators of disease in several models for autoimmunity in ..
  28. Regulation of ENaC in salt-sensitive hypertension via inflammation-induced ROS pr
    TENGIS SANALOVICH PAVLOV; Fiscal Year: 2013
    ..Treatment with ENaC inhibitor benzamil attenuates increase in blood pressure in SS rats. Infiltrating T lymphocytes in the kidney increase oxidative stress and participate in the development of salt-sensitive hypertension in ..
  29. Structure and function of Helicobacter pylori VacA
    Timothy L Cover; Fiscal Year: 2013
    ..VacA causes multiple alterations in gastric epithelial cells, and inhibits activation and proliferation of T lymphocytes. Most cellular effects of VacA are dependent on its ability to form anion-selective membrane channels...
  30. Functional Genomics Approach to the Role of the JAK/STAT and MAPK Pathway in CBD
    Li Li; Fiscal Year: 2013
    ..Her research was highly focused on the cell-cell immunological synapse interactions between activated memory T lymphocytes and antigen presenting cells...
  31. A translational model of neuro-immune therapy for PTSD in veterans of the OEF/OIF
    Leonardo H Tonelli; Fiscal Year: 2013
    ..Recent studies indicate that T lymphocytes are protective against the development of posttraumatic stress and anxiety as suggested by studies in mice...
  32. Define the role of dendritic cells in HTLV-1 associated neuroinflammatory disease
    Pooja Jain; Fiscal Year: 2013
    ..progression of HAM/TSP is characterized by an intense proliferation of chronically activated CD8+ cytotoxic T lymphocytes (CTLs), 90% of which are specific for the HTLV-1 transactivator protein Tax...
  33. The Role of PPAR Gamma in Fat-Resident Regulatory T Cells and Glucose Homeostasis
    SAGAR PRADEEP BAPAT; Fiscal Year: 2013
    ..Specifically, regulatory T cells (Tregs), a subset of T lymphocytes with an immunosuppressive function, are enriched in adipose tissue of lean, but not obese, mice...
  34. The role of regulatory T cells in biliary atresia
    Alexander Miethke; Fiscal Year: 2013
    ....
  35. Role of T Cell Mediated Immunity In Emotion And Stress Responsiveness
    Leonardo H Tonelli; Fiscal Year: 2012
    ..The present application will evaluate if activated T lymphocytes in the periphery are necessary and sufficient to induce emotional behavioral changes...
  36. Identification of stromal responses during castration-induced thymic regrowth.
    Howard T Petrie; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Under normal conditions, most T lymphocytes are made in the thymus. Unfortunately, the size of the thymus degenerates progressively with age, with a noticeable onset at around the time of puberty...
  37. Polymicrobial interactions in the lung.
    JENNIFER MELINDA BOMBERGER; Fiscal Year: 2010
    ..suppresses influenza A virus antigen presentation by class I MHC molecules and the ability of cytotoxic T lymphocytes (CTL) to clear viral infections...
  38. Role of interleukin-17 and iNKT cells in COPD
    ABDALA EL KHAL; Fiscal Year: 2010
    ..the epithelial barrier and induces a migration of different cell type such as neutrophils, macropages, T lymphocytes and natural killer cells through the airway epithelium...
  39. Integration of mucosal immune responses through the enteric nervous system
    DANIEL S MUCIDA; Fiscal Year: 2013
    ..Not surprisingly, the immune system associated with the intestine accounts for the majority of B and T lymphocytes in the body...
  40. Discovery of Critical Host Genes Enabling Resistance to HIV-1 Infection as Therap
    Leyla S Diaz; Fiscal Year: 2012
    ..To this end, we have discovered that Robo1 expression is activated in primary CD4+ T lymphocytes by HIV-1 infection. As a result, Robo1 uniquely appears on the surface of live, viral producing cells...
  41. Adipose Stem Cell Therapy for Krabbe Disease
    Bruce Bunnell; Fiscal Year: 2009
    ..complicated by graft versus host disease, a severe immunological disorder characterized by engrafted cytotoxic T lymphocytes destruction of host tissues including the skin epithelium, intestinal mucosa, and kidneys...
  42. Hematopoietic Cell Transplantation and Iron Overload
    H Joachim Deeg; Fiscal Year: 2013
    ..Preliminary results in murine models indicate that transplantation of allogeneic (but not syngeneic) T lymphocytes results in altered expression of hepcidin and ferroportin 1, and dysregulation of iron homeostasis...
  43. HLA class II transgenic mouse models for S. aureus infections and superantigens
    Govindarajan Rajagopalan; Fiscal Year: 2013
    ..The superantigen exotoxins (SAg) are important amongst them because SAg are the most potent activators of T lymphocytes known. Certain SAg could also be used as biological weapons. Thus, SAg are important from many perspectives...
  44. Regulation of HBV Replication by the Immune System
    Luca G Guidotti; Fiscal Year: 2012
    ..Specifically, cytotoxic T lymphocytes (CTLs) play a major part in the development of liver disease and the resolution of HBV infection...
  45. Role of SATB in placental development
    Mohammad A K Rumi; Fiscal Year: 2013
    ..They participate in transcriptional regulation of key genes controlling the differentiation of T lymphocytes, osteoblasts, cortical neurons, and embryonic stem cells...
  46. Non-Human Primate Model of Gluten-Sensitive Enteropathy
    Karol Sestak; Fiscal Year: 2013
    ..2 (TG2) antibodies, villous atrophy, increased presence of IELs and inflammatory-cytokine producing intestinal T lymphocytes in macaques with clinical or subclinical GSE vs. controls will be evaluated...
  47. Crossprotective CTL Against Influenza
    Ellis L Reinherz; Fiscal Year: 2013
    ..Since tissue-resident peripheral memory effector CD8 T lymphocytes can mediate cytokine release and other terminally differentiated functions within hours of T cell receptor ..
  48. Novel functions of RGS3
    Nickolai O Dulin; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Appropriate function of T lymphocytes is critical for the adaptive immunity, whereas abnormal function of T cells leads to autoimmune and ..
  49. The Role of Beta-Arrestins 1 and 2 in Rheumatoid Arthritis
    Hongkuan Fan; Fiscal Year: 2010
    ..arrestin 1 and 2 expression in splenic macrophages, CD4+ and CD8+ T lymphocytes, B lymphocytes, dendritic cells (DC)s, polymorphonuclear leukocyte (PMN)s and FLS correlation to the disease ..
  50. Immune Regulation of Virus Clearance and Tissue Injury at Sites of Infection
    Thomas J Braciale; Fiscal Year: 2013
    ..e. dendritic cells, monocyte/ macrophage, NK cells and adaptive immune effector T lymphocytes (Te) in the process of virus clearance and in the control of inflammation/injury during experimental virus ..
  51. Molecular elucidation of the CBM complex in NF-kappaB activation by antigen recep
    Hao Wu; Fiscal Year: 2013
    ..1) acts downstream of PKC? and PKC[unreadable] to induced activation of the IkB kinase (IKK) in both B and T lymphocytes (Figure 1). CARMA1 appears to be constitutively associated with the cytoplasmic membrane...
  52. Viral mechanisms of adipocyte dysfuntion: Role of Vpr.
    Ashok Balasubramanyam; Fiscal Year: 2012
    ..blocking differentiation and inducing apoptosis of preadipocytes and adipocytes, when exposed to HIV-infected T lymphocytes;4...
  53. Innate and Adaptive Immune Mechanisms in Arthritis
    RICHARD J BUCALA; Fiscal Year: 2013
    ..Our working hypothesis is that signaling through the MIF receptor sustains the survival of activated T lymphocytes and regulates the adaptive immune response. 2...
  54. GB Virus C and Non-Hodgkins Lymphoma Risk and Prognosis
    Jack T Stapleton; Fiscal Year: 2013
    ..Specifically, GBV-C infection causes persistent infection of humans, replicates in B and T lymphocytes, prolongs survival of lymphocytes and is associated with delayed apoptosis in vivo and in vitro...
  55. HCV in Alcoholics
    Jack R Wands; Fiscal Year: 2011
    ..These investigations open new avenues to enhance antiviral immune response in the setting of chronic ethanol consumption by improving DC function. ..
  56. Stress-induced hypertension and the role of the neuroimmune system
    PAUL MARVAR; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): It has been become increasingly clear that T lymphocytes play an important role in the pathophysiology of hypertension and more recently in psychological stress and depression related disabilities...
  57. Functional Analysis of PAAN-AG5, the Baboon Counterpart of HLA-G5
    Daudi K Langat; Fiscal Year: 2010
    ..This proposal is aimed at assessing the feasibility of using the olive baboon as a model for HLA-G in vivo experiments. ..
  58. Polymicrobial Interactions in the Lung
    JENNIFER MELINDA BOMBERGER; Fiscal Year: 2013
    ..suppresses influenza A virus antigen presentation by class I MHC molecules and the ability of cytotoxic T lymphocytes (CTL) to clear viral infections...
  59. Use of Allogenicity to Stimulate Effector Responses Against Multiple Myeloma
    Christina N Johnson; Fiscal Year: 2013
    ..Multiple myeloma cells, has been shown to stimulate interferon gamma expression by myeloma-specific cytotoxic T lymphocytes (CTLs)7...
  60. The role of T lymphocytes in mediating hypertension during pregnancy
    Kedra L Wallace; Fiscal Year: 2013
    ..Our preliminary data indicate the RUPP is associated with elevated lymphocytes adoptive transfer of these T lymphocytes into normal pregnant rats causes hypertension and AT1-AA production...
  61. Integrin-dependent mechanism of T cell-mediated pulmonary fibrosis
    Irina G Luzina; Fiscal Year: 2012
    ..a TGF-2-associated regulatory phenotype of T cells and with lower pulmonary function, whereas infiltration of T lymphocytes not expressing integrins is associated with inflammatory phenotype and higher pulmonary function in patients ..
  62. Stem cell-mediated reversal of thymic involution in premature aging models
    Kenneth I Weinberg; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: T lymphocytes are cells of the immune system that control the body's response to infection...
  63. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael J Bevan; Fiscal Year: 2012
    ..Cytotoxic T lymphocytes which express the CD8 marker, are of vital importance in the response to many intracellular infectious agents...
  64. Signaling in Thymocyte Selection
    Gerald R Crabtree; Fiscal Year: 2010
    ..AI060037 -06 shape repertoire lymphocytes has been one the most The mechanisms that shape the repertoire of T lymphocytes has been one of the most enduring mysteries in immunology...
  65. TH1 CYTOKINES AND IMPAIRED CD8* CTLS IN ELDERLY
    Innocent Mbawuike; Fiscal Year: 2001
    ..Applicant's Abstract): The objectives of this proposal are to determine the mechanisms of deficient cytotoxic T lymphocytes (CD8+ CTL) activity against influenza virus among elderly persons and how this deficiency can be corrected...
  66. Exploring How HTLV-1 Tax Induces T Cell Leukemia
    Warner Greene; Fiscal Year: 2006
    ..1) the Adult T Cell Leukemia (ATL), an aggressive and usually fatal neoplastic expansion of activated CD4+ T lymphocytes; (2) Tropical Spastic Paraparesis/HTLV-I associated myelopathy (TSP/HAM), a progressive neurodegenerative ..
  67. Immune Tolerance; Sigma Receptor as a Therapeutic Target
    Vadivel Ganapathy; Fiscal Year: 2003
    ..hypotheses: 1) Progesterone and several pharmacological ligands suppress the function and proliferation of T lymphocytes by acting as specific ligands for the sigma 1 receptor; 2) sigma 1 receptor produces its effects by ..
  68. ACTIVATION OF PERIODONTAL FIBROBLASTS VIA CD40
    Timothy Blieden; Fiscal Year: 2000
    ..b>T lymphocytes are closely associated with early events in periodontal inflammation and may act to stimulate fibroblast ..
  69. ROLE OF T LYMPHOCYTE FACTORS IN HEMOPOIESIS 0
    Michael Prystowsky; Fiscal Year: 1992
    ..Inflammation is a complex host response that involves several biochemical pathways and all hemopoietic elements. T lymphocytes play an integral role in inflammatory responses by secreting soluble protein factors, lymphokines, that can ..
  70. Specialized Centers for Cell-Based Therapy for NHLBI an*
    Shelly Carter; Fiscal Year: 2009
    ..a broad range of products and proposed indications for use including tumor-infiltrating lymphocytes, activated T lymphocytes for treatment of viral infections, a marketed cartilage cellular product for treatment of cartilage injuries, ..
  71. CLONAL DOMINANCE OF T-LYMPHOCYTES IN ARTHRITIS
    JAMES KURNICK; Fiscal Year: 1991
    This proposal will focus on characterization of T lymphocytes in arthritis...
  72. Measurement of CCR5 and CCL3L1 on Single Cell by Fluorescent Metal Nanoparticle
    Richard Yuqi Zhao; Fiscal Year: 2010
    ....
  73. IRRITANTS EFFECTS ON EPIDERMAL ANTIGEN PRESENTATION
    Anthony Gaspari; Fiscal Year: 2002
    ....
  74. HIV-1 Specific Cytotoxic T Lymphocytes in Breastmilk
    Grace John Stewart; Fiscal Year: 2003
    ..Some uninfected infants born to HIV-1 infected women generate HIV-1 specific cytotoxic T lymphocytes (CTLs), suggesting viral antigenic exposure sufficient to induce immunity but not to establish infection...