natural killer cells

Summary

Summary: Cells responsible for spontaneous cytotoxicity of a variety of tumor cells without prior immunization. These natural killer cells are found in non-immune humans and experimental animals and are thought by some to be the same as KILLER CELLS (killing by antibody-dependent cell cytotoxicity), but they can also kill in the absence of antibody.

Top Publications

  1. ncbi Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
    O Mandelboim
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassha Medical School, Jerusalem, Israel
    Nature 409:1055-60. 2001
  2. ncbi Functions of natural killer cells
    Eric Vivier
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, Campus de Luminy, 13288 Marseille, France
    Nat Immunol 9:503-10. 2008
  3. pmc Influenza virus directly infects human natural killer cells and induces cell apoptosis
    Huawei Mao
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, People s Republic of China
    J Virol 83:9215-22. 2009
  4. pmc Human natural killer cells
    Michael A Caligiuri
    The Ohio State University Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, 300 West 10th St, Rm 517, Columbus, OH 43210, USA
    Blood 112:461-9. 2008
  5. ncbi NK cell recognition
    Lewis L Lanier
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco School of Medicine, San Francisco, California 94143 0414, USA
    Annu Rev Immunol 23:225-74. 2005
  6. ncbi CD107a as a functional marker for the identification of natural killer cell activity
    Galit Alter
    Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Massachusetts, USA
    J Immunol Methods 294:15-22. 2004
  7. ncbi CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides
    T Kawano
    CREST Core Research for Evolutional Science and Technology Project, Japan Science and Technology Corporation JST, 1 8 1 Inohana, Chuo, Chiba 260, Japan
    Science 278:1626-9. 1997
  8. ncbi The biology of human natural killer-cell subsets
    M A Cooper
    Dept of Veterinary Biosciences and Comprehensive Cancer Center, The Ohio State University, 458A Starling-Loving Hall, 320 West 10th Ave, Columbus, OH 43210, USA
    Trends Immunol 22:633-40. 2001
  9. pmc Adaptive immune features of natural killer cells
    Joseph C Sun
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, California 94143, USA
    Nature 457:557-61. 2009
  10. ncbi HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection
    Salim I Khakoo
    Liver Group, Division of Infection, Inflammation, and Repair, Southampton University, Southampton 5016 6YD, UK
    Science 305:872-4. 2004

Detail Information

Publications293 found, 100 shown here

  1. ncbi Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
    O Mandelboim
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassha Medical School, Jerusalem, Israel
    Nature 409:1055-60. 2001
    ..These findings indicate how NKp46-expressing NK cells may recognize target cells infected by influenza or parainfluenza without the decreased expression of target-cell MHC class I protein...
  2. ncbi Functions of natural killer cells
    Eric Vivier
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, Campus de Luminy, 13288 Marseille, France
    Nat Immunol 9:503-10. 2008
    ....
  3. pmc Influenza virus directly infects human natural killer cells and induces cell apoptosis
    Huawei Mao
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, People s Republic of China
    J Virol 83:9215-22. 2009
    ....
  4. pmc Human natural killer cells
    Michael A Caligiuri
    The Ohio State University Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, 300 West 10th St, Rm 517, Columbus, OH 43210, USA
    Blood 112:461-9. 2008
    ..The most recent discoveries in NK-cell receptor biology have fueled translational research that has led to remarkable results in treating human malignancy...
  5. ncbi NK cell recognition
    Lewis L Lanier
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco School of Medicine, San Francisco, California 94143 0414, USA
    Annu Rev Immunol 23:225-74. 2005
    ..Here, I review the structure, function, and ligand specificity of the receptors responsible for NK cell recognition...
  6. ncbi CD107a as a functional marker for the identification of natural killer cell activity
    Galit Alter
    Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Massachusetts, USA
    J Immunol Methods 294:15-22. 2004
    ..Cumulatively, the data presented here demonstrate that CD107a is a sensitive marker of NK cell activity...
  7. ncbi CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides
    T Kawano
    CREST Core Research for Evolutional Science and Technology Project, Japan Science and Technology Corporation JST, 1 8 1 Inohana, Chuo, Chiba 260, Japan
    Science 278:1626-9. 1997
    ..Thus, this lymphocyte shares distinct recognition systems with either T or NK cells...
  8. ncbi The biology of human natural killer-cell subsets
    M A Cooper
    Dept of Veterinary Biosciences and Comprehensive Cancer Center, The Ohio State University, 458A Starling-Loving Hall, 320 West 10th Ave, Columbus, OH 43210, USA
    Trends Immunol 22:633-40. 2001
    ..In addition, we will discuss other cell-surface receptors expressed differentially by human NK-cell subsets and the distinct functional properties of these subsets...
  9. pmc Adaptive immune features of natural killer cells
    Joseph C Sun
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, California 94143, USA
    Nature 457:557-61. 2009
    ..These findings reveal properties of NK cells that were previously attributed only to cells of the adaptive immune system...
  10. ncbi HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection
    Salim I Khakoo
    Liver Group, Division of Infection, Inflammation, and Repair, Southampton University, Southampton 5016 6YD, UK
    Science 305:872-4. 2004
    ..The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV...
  11. ncbi The biology of NKT cells
    Albert Bendelac
    Howard Hughes Medical Institute, Committee on Immunology, Department of Pathology University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Immunol 25:297-336. 2007
    ....
  12. ncbi Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
    Maureen P Martin
    Basic Research Program, SAIC Frederick, Frederick, Maryland 21702 1201, USA
    Nat Genet 31:429-34. 2002
    ..The strongest synergistic effect of these loci was on progression to depletion of CD4(+) T cells, which suggests that a protective response of NK cells involving KIR3DS1 and its HLA class I ligands begins soon after HIV-1 infection...
  13. ncbi Cloning of a new cytokine that induces IFN-gamma production by T cells
    H Okamura
    Department of Bacteriology, Hyogo College of Medicine, Nishinomiya, Japan
    Nature 378:88-91. 1995
    ..IGIF may be involved in the development of Th1 cells and also in mechanisms of tissue injury in inflammatory reactions...
  14. ncbi Natural killer cells in antiviral defense: function and regulation by innate cytokines
    C A Biron
    Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island 02912, USA
    Annu Rev Immunol 17:189-220. 1999
    ....
  15. ncbi Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
    D Kagi
    Department of Pathology, University of Zurich, Switzerland
    Nature 369:31-7. 1994
    ..been generated by homologous recombination to determine whether the effects of CD8+ cytolytic T cells and natural killer cells are mediated by pore formation involving perforin...
  16. pmc Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
    Maureen P Martin
    Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Inc, National Cancer Institute, P O Box B, Building 560, Frederick, Maryland 21702, USA
    Nat Genet 39:733-40. 2007
    ....
  17. ncbi Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2
    Grazia Maria Spaggiari
    Centro di Eccellenza per la Ricerca Biomedica, Biologia e Genetica, Universita di Genova, Genova, Italy
    Blood 111:1327-33. 2008
    ..Finally, we demonstrate that indoleamine 2,3-dioxygenase and prostaglandin E2 represent key mediators of the MSC-induced inhibition of NK cells...
  18. ncbi Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset
    M A Cooper
    Department of Internal Medicine, Division of Hematology/Oncology, The Ohio State University, Columbus, OH, USA
    Blood 97:3146-51. 2001
    ..It is proposed that human CD56(bright) NK cells have a unique functional role in the innate immune response as the primary source of NK cell-derived immunoregulatory cytokines, regulated in part by differential monokine production...
  19. pmc Reciprocal activating interaction between natural killer cells and dendritic cells
    Franca Gerosa
    Department of Pathology, Section of Immunology, University of Verona, 37100 Verona, Italy
    J Exp Med 195:327-33. 2002
    ..These data demonstrated for the first time a bidirectional cross talk between NK cells and DC, in which NK cells activated by IL-2 or by mature DC induce DC maturation...
  20. ncbi Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
    Jochen Mattner
    Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA
    Nature 434:525-9. 2005
    ..These findings identify two novel antigenic targets of NKT cells in antimicrobial defence, and show that glycosylceramides are an alternative to LPS for innate recognition of the Gram-negative, LPS-negative bacterial cell wall...
  21. ncbi The trafficking of natural killer cells
    Claude Gregoire
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Immunol Rev 220:169-82. 2007
    ..Here, we describe the tissue localization of NK cells, using NKp46 as an NK cell marker, and review the current knowledge on the mechanisms that govern their trafficking in humans and in mice...
  22. ncbi The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
    G B Cohen
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Immunity 10:661-71. 1999
    ..These results suggest that subpopulations of CTL and NK cells may be uniquely suited for combating HIV...
  23. ncbi Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer
    Jeffrey S Miller
    Division Medical and Pediatric Hematology Oncology, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Blood 105:3051-7. 2005
    ..These findings suggest that haploidentical NK cells can persist and expand in vivo and may have a role in the treatment of selected malignancies used alone or as an adjunct to HCT...
  24. pmc A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
    Marina Cella
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 457:722-5. 2009
    ....
  25. ncbi CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity
    Todd A Fehniger
    Department of Internal Medicine, Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
    Blood 101:3052-7. 2003
    ..These data show a dynamic interaction between innate and adaptive human lymphocytes and emphasize the importance of studying interactions between immune components to understand the immune response as a whole...
  26. ncbi Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    Loredana Ruggeri
    Department of Clinical and Experimental Medicine, Section of Hematology and Clinical Immunology, Perugia University School of Medicine, Perugia, Italy
    Science 295:2097-100. 2002
    ..NK cell alloreactivity may thus provide a powerful tool for enhancing the efficacy and safety of allogeneic hematopoietic transplantation...
  27. pmc Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity
    A Diefenbach
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley 94720, USA
    Nature 413:165-71. 2001
    ....
  28. ncbi Human NK cell education by inhibitory receptors for MHC class I
    Nicolas Anfossi
    Innate Pharma, 13009 Marseille, France
    Immunity 25:331-42. 2006
    ..These results show the involvement of KIR-MHC class I interactions in the calibration of NK cell effector capacities, suggesting its role in the subsequent "missing self" recognition...
  29. ncbi Diverse herpesvirus microRNAs target the stress-induced immune ligand MICB to escape recognition by natural killer cells
    Daphna Nachmani
    The Lautenberg Center for General and Tumor Immunology, Institute for Medical Research Israel Canada, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Cell Host Microbe 5:376-85. 2009
    ..The finding that different herpesvirus microRNAs target MICB indicates that MICB plays a pivotal role in the clash between herpesviruses and humans...
  30. ncbi Epstein-Barr virus: 40 years on
    Lawrence S Young
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, B15 2TT, UK
    Nat Rev Cancer 4:757-68. 2004
    ..Despite such ubiquity, the link between EBV and 'endemic' Burkitt's lymphoma proved consistent and became the first of an unexpectedly wide range of associations discovered between this virus and tumours...
  31. ncbi Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2
    Y Yokota
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Nature 397:702-6. 1999
    ..Our results indicate that Id2 has an essential role in the generation of peripheral lymphoid organs and NK cells...
  32. ncbi Interactions between human mesenchymal stem cells and natural killer cells
    Panagiota A Sotiropoulou
    Cancer Immunology and Immunotherapy Center, Saint Savas Hospital, 171 Alexandras Ave, 115 22, Athens, Greece
    Stem Cells 24:74-85. 2006
    ....
  33. pmc Up on the tightrope: natural killer cell activation and inhibition
    Lewis L Lanier
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, California 94143 0414, USA
    Nat Immunol 9:495-502. 2008
    ....
  34. ncbi Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
    S Bauer
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Science 285:727-9. 1999
    ..These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses...
  35. pmc Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
    M K Kennedy
    Immunex Corporation, Seattle, Washington 98101, USA
    J Exp Med 191:771-80. 2000
    ..Moreover, the ability to rescue lymphoid defects in IL-15(-/-) mice by IL-15 administration represents a powerful means by which to further elucidate the biological roles of this cytokine...
  36. pmc Dendritic cells prime natural killer cells by trans-presenting interleukin 15
    Mathias Lucas
    Skirball Institute of Biomolecular Medicine, Program in Molecular Pathogenesis, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Immunity 26:503-17. 2007
    ..Our data define a unique in vivo role of DCs for the priming of NK cells, revealing a striking and previously unappreciated homology to T lymphocytes of the adaptive immune system...
  37. ncbi Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
    D K Dalton
    Genentech Inc, South San Francisco, CA 94080
    Science 259:1739-42. 1993
    ..Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system...
  38. ncbi Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
    J Parrish-Novak
    Department of Functional Cloning, ZymoGenetics, Inc, Seattle, Washington 98102, USA
    Nature 408:57-63. 2000
    ....
  39. ncbi Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis
    A Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Italy
    Annu Rev Immunol 19:197-223. 2001
    b>Natural killer cells can discriminate between normal cells and cells that do not express adequate amounts of major histocompatibility complex (MHC) class I molecules...
  40. pmc Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells
    Natasha K Crellin
    Department of Immunology, Genentech, South San Francisco, CA 94080, USA
    J Exp Med 207:281-90. 2010
    ..Overall, we propose that CD127(+)RORC(+) cells, although they share some characteristics with cNK cells, represent a functionally and developmentally distinct lineage...
  41. ncbi Licensing of natural killer cells by host major histocompatibility complex class I molecules
    Sungjin Kim
    Howard Hughes Medical Institute, Rheumatology Division, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 436:709-13. 2005
    ..This self-tolerance mechanism may be more broadly applicable within the vertebrate immune system because related germline-encoded inhibitory receptors are widely expressed on other immune cells...
  42. ncbi Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells
    H J McKenna
    Immunex Corporation, Seattle, WA 98101, USA
    Blood 95:3489-97. 2000
    ..We conclude that flt3L has an important role in the expansion of early hematopoietic progenitors and in the generation of mature peripheral leukocytes...
  43. ncbi T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells
    Michael J Townsend
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
    Immunity 20:477-94. 2004
    ..Our results identify T-bet as a key factor in the terminal maturation and peripheral homeostasis of NK and Valpha14i NKT cells...
  44. pmc Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success
    Susan E Hiby
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, England, UK
    J Exp Med 200:957-65. 2004
    ..In light of our findings, reproductive success may have been a factor in the evolution and maintenance of human HLA-C and KIR polymorphisms...
  45. ncbi Natural killer cell signaling pathways
    Eric Vivier
    Centre d immunologie de Marseille Luminy, INSERM CNRS Univ Méditerranée, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Science 306:1517-9. 2004
    ..Understanding the integration of these multiple signals is central to the understanding and manipulation of NK cell effector signaling pathways...
  46. pmc Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46
    Thierry Walzer
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, 13288 Marseille, France
    Proc Natl Acad Sci U S A 104:3384-9. 2007
    ..DT injection in these mice leads to a complete and selective NK cell ablation. This model paves a way for the in vivo characterization and preclinical assessment of NK cell biological function...
  47. ncbi Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense
    Naoko Satoh-Takayama
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris F 75724, France
    Immunity 29:958-70. 2008
    ..RORgammat-driven diversification of intestinal NKp46+ cells thereby specifies an innate cellular defense mechanism that operates at mucosal surfaces...
  48. pmc Cytokine-induced memory-like natural killer cells
    Megan A Cooper
    Rheumatology Division, Department of Medicine, and Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:1915-9. 2009
    ..Thus, these experiments identify an ability of innate immune cells to retain an intrinsic memory of prior activation, a function until now attributed only to antigen-specific adaptive immune cells...
  49. ncbi NK cell compartments and their activation by dendritic cells
    Guido Ferlazzo
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Immunol 172:1333-9. 2004
  50. ncbi The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development
    Duncan M Gascoyne
    Molecular Haematology and Cancer Biology Unit, University College London Institute of Child Health and Great Ormond Street Hospital for Children, London, UK
    Nat Immunol 10:1118-24. 2009
    ..E4bp4(-/-) mice may provide a model for definitive analysis of the contribution of NK cells to immune responses and pathologies...
  51. pmc Posttranscriptional regulation of II10 gene expression allows natural killer cells to express immunoregulatory function
    Asher Maroof
    Immunology and Infection Unit, Hull York Medical School and Department of Biology, University of York, Wentworth Way, York YO10 5YW, UK
    Immunity 29:295-305. 2008
    ....
  52. ncbi Mechanism of CD1d-restricted natural killer T cell activation during microbial infection
    Manfred Brigl
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1230-7. 2003
    ..We propose this mechanism of activation as a major pathway responsible for the rapid activation of NKT cells in different microbial infections...
  53. pmc A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells
    M Colonna
    Basel Institute for Immunology, Basel CH 4005, Switzerland
    J Exp Med 186:1809-18. 1997
    ..These results suggest that diverse leukocyte lineages have adopted recognition of self-MHC class I molecules as a common strategy to control cellular activation during an immune response...
  54. ncbi Recognition of bacterial glycosphingolipids by natural killer T cells
    Yuki Kinjo
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, 10355 Science Center Drive, San Diego, California 92121, USA
    Nature 434:520-5. 2005
    ....
  55. ncbi An activating immunoreceptor complex formed by NKG2D and DAP10
    J Wu
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    Science 285:730-2. 1999
    ..Thus, NKG2D-DAP10 receptor complexes may activate NK and T cell responses against MICA-bearing tumors...
  56. ncbi NKT cells: what's in a name?
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Nat Rev Immunol 4:231-7. 2004
  57. ncbi Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming
    Alfonso MartIn-Fontecha
    Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland
    Nat Immunol 5:1260-5. 2004
    ..Taken together, our results identify an induced pathway of NK cell migration in antigen-stimulated lymph nodes and a mechanism by which some adjuvants may facilitate T(H)1 responses...
  58. ncbi Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells
    Ida Rasmusson
    Department of Clinical Immunology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Transplantation 76:1208-13. 2003
    ..There are no publications on the effect that MSCs have on cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, effector cells vital for the graft-versus-leukemia effect...
  59. ncbi Natural killer cells as an initial defense against pathogens
    Melissa B Lodoen
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, 94143 0414, USA
    Curr Opin Immunol 18:391-8. 2006
    ..Recent studies have focused on the mechanisms by which NK cells recognize and respond to viruses, parasites and bacteria, and on the unique role of NK cells in innate immunity to infection...
  60. pmc Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function
    Venkateswara Rao Simhadri
    Laboratory of Immune Therapy, Department of Internal Medicine I, Centre for Integrated Oncology Koeln Bonn, University of Cologne, Cologne, Germany
    PLoS ONE 3:e3377. 2008
    ..The manipulation of the exosomal regulation may offer a novel strategy to induce tumor immunity or inhibit autoimmune diseases caused by NK cell-activation...
  61. ncbi Prospects for the use of NK cells in immunotherapy of human cancer
    Hans Gustaf Ljunggren
    Centre for Infectious Medicine, Department of Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden
    Nat Rev Immunol 7:329-39. 2007
    ..Appropriately used, we predict that NK cells will have a role, both directly and in combination with other treatment modalities, in future treatment of cancer...
  62. ncbi Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs
    Todd A Fehniger
    Division of Oncology, Department of Internal Medicine, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 26:798-811. 2007
    ..These data suggest that resting murine NK cells are minimally cytotoxic because of a block in perforin and granzyme B mRNA translation that is released by NK cell activation...
  63. ncbi Recognition of viral hemagglutinins by NKp44 but not by NKp30
    T I Arnon
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
    Eur J Immunol 31:2680-9. 2001
    ..221 cells expressing MHC class I proteinsresulted in the abrogation of the inhibition by NK clones expressing high levels of NKp44. In addition, the binding of NKp44 to HA improves the ability of some NK clones to lyse IV infected cells...
  64. ncbi The dynamic life of natural killer cells
    Wayne M Yokoyama
    Howard Hughes Medical Institute, Rheumatology Division, Department of Medicine, Department of Pathology and Immunology, St Louis, Missouri 63110, USA
    Annu Rev Immunol 22:405-29. 2004
    ....
  65. ncbi Decidual NK cells regulate key developmental processes at the human fetal-maternal interface
    Jacob Hanna
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Nat Med 12:1065-74. 2006
    ..The overall results support a 'peaceful' model for reproductive immunology, in which elements of innate immunity have been incorporated in a constructive manner to support reproductive tissue development...
  66. pmc Membrane nanotubes facilitate long-distance interactions between natural killer cells and target cells
    Anne Chauveau
    Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 107:5545-50. 2010
    ..Finally, target cells that remained connected to an NK cell by a nanotube were frequently lysed, whereas removing the nanotube using a micromanipulator reduced lysis of these target cells...
  67. ncbi New aspects of natural-killer-cell surveillance and therapy of cancer
    Mark J Smyth
    Cancer Immunology Laboratory, Trescowthick Research Laboratories, Research Division, Peter MacCallum Cancer Institute, Locked Bag 1, A Beckett Street, Melbourne 8006, Australia
    Nat Rev Cancer 2:850-61. 2002
  68. pmc Line of attack: NK cell specificity and integration of signals
    Yenan T Bryceson
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Curr Opin Immunol 20:344-52. 2008
    ..New insights into the molecular checkpoints for NK cell effector function are highlighted, and underlying reasons for the complexity in NK cell recognition and signaling are proposed...
  69. ncbi Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors
    N M Valiante
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Immunity 7:739-51. 1997
    ..Because of these differences, the first donor has subpopulations of NK cells that kill cells of the second donor, whereas the NK cells of the second donor are universally tolerant of cells from the first donor...
  70. ncbi NKT cells: facts, functions and fallacies
    D I Godfrey
    Dept of Pathology and Immunology, Monash University Medical School, Commercial Road, VIC 3181, Prahran, Australia
    Immunol Today 21:573-83. 2000
    ..Heterogeneity of these cells contributes to the controversy surrounding their development and function. This review aims to provide an update on NKT cell biology and, whenever possible, to compare what is known about NKT-cell subsets...
  71. pmc Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value
    Loredana Ruggeri
    Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Istituto di Ricovero e Cura a Carattere Scientifico, Foundation on Transplantation Biotechnologies, Perugia, Italy
    Blood 110:433-40. 2007
    ..Only transplantation from NK-alloreactive donors is associated with a survival advantage...
  72. ncbi Activated, but not resting, T cells can be recognized and killed by syngeneic NK cells
    Brian A Rabinovich
    Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Canada
    J Immunol 170:3572-6. 2003
    ..Our data provide a basis for studying a role for NK cells in T cell regulation...
  73. ncbi CD56brightCD16- killer Ig-like receptor- NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation
    Chiara Romagnani
    Department of Clinical Immunology, German Rheumatism Research Centre, Deutsches Rheuma ForschungsZentrum Berlin, Berlin, Germany
    J Immunol 178:4947-55. 2007
    ....
  74. pmc Plasticity in the organization and sequences of human KIR/ILT gene families
    M J Wilson
    Immunology Division, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, United Kingdom
    Proc Natl Acad Sci U S A 97:4778-83. 2000
    ..KIR genesis was followed by extensive duplication/deletion as well as intergenic sequence exchange, reminiscent of MHC class I genes, which provide KIR ligands...
  75. pmc Evidence for discrete stages of human natural killer cell differentiation in vivo
    Aharon G Freud
    Medical Scientist Program, The Ohio State University, Columbus, OH 43210, USA
    J Exp Med 203:1033-43. 2006
    ....
  76. ncbi Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection
    Galit Alter
    Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, USA
    Blood 106:3366-9. 2005
    ..Taken together, these studies demonstrate a sequential impairment of NK cell function with persistent viral replication resulting from a progressive deregulation of NK cell subsets with distinct functional properties...
  77. ncbi TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bukyou ku, Tokyo 113 8421, Japan
    Blood 105:2082-9. 2005
    ..This study is the first to describe the concomitant maturation of NK cell effector function with surface phenotype in vivo and implies an important defense role for NK cell TRAIL in the developing immune system...
  78. pmc Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis
    Bibiana Bielekova
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:5941-6. 2006
    ..This immunoregulation has potential importance for the treatment of autoimmune diseases and transplant rejection and toward modification of tumor immunity...
  79. ncbi The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic
    Guido Ferlazzo
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Immunol 172:1455-62. 2004
    b>Natural killer cells are important cytolytic cells in innate immunity. We have characterized human NK cells of spleen, lymph nodes, and tonsils...
  80. ncbi Natural killer cells and dendritic cells: rendezvous in abused tissues
    Alessandro Moretta
    Dipartimento di Medicina Sperimentale, Sezione di Istologia, and Centro di Eccellenza per le Ricerche Biomediche, Universita degli Studi di Genova, 16132 Genova, Italy
    Nat Rev Immunol 2:957-64. 2002
    ....
  81. ncbi CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity
    Yoshihiro Hayakawa
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Immunol 176:1517-24. 2006
    ..These findings clearly reclassify mature NK cells into two distinct subsets and begin to discern their specific role in immune responses...
  82. ncbi Increase of regulatory T cells in the peripheral blood of cancer patients
    Anna Maria Wolf
    Institute for Biomedical Aging Research, Austrian Academy of Sciences, 6020 Innsbruck, Austria
    Clin Cancer Res 9:606-12. 2003
    ..Experimental tumor models in mice revealed that Tregs are potent inhibitors of an antitumor immune response. The current study was designed to determine whether cancer patients exhibit an expanded Treg pool...
  83. ncbi Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1
    Roi Gazit
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Nat Immunol 7:517-23. 2006
    The elimination of viruses and tumors by natural killer cells is mediated by specific natural killer cell receptors...
  84. pmc Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo
    A Cerwenka
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143-0414, USA
    Proc Natl Acad Sci U S A 98:11521-6. 2001
    ..Therefore, NK cells are able to reject a tumor expressing RAE-1 molecules, despite expression of self MHC class I on the tumor, demonstrating the potential for NK cells to participate in immunity against class I-bearing malignancies...
  85. pmc A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells
    S Rajagopalan
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Exp Med 189:1093-100. 1999
    ..Therefore, given that HLA-G expression is restricted to fetal trophoblast cells, KIR2DL4 may provide important signals to maternal NK decidual cells that interact with trophoblast cells at the maternal-fetal interface during pregnancy...
  86. ncbi A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells
    Kristin Hochweller
    Division of Molecular Immunology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, Heidelberg, Germany
    Eur J Immunol 38:2776-83. 2008
    ..Importantly, DC were found to play an instrumental role for maintaining normal homeostasis of NK cells. This is achieved by IL-15 production by DC, which supports the homeostatic proliferation of NK cells...
  87. pmc Cytotoxicity of activated natural killer cells against pediatric solid tumors
    Duck Cho
    Department of Oncology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Clin Cancer Res 16:3901-9. 2010
    ..We sought to identify the most sensitive tumor subtypes, clarify the molecular interactions regulating cytotoxicity, and determine NK antitumor potential in vivo...
  88. pmc Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent manner
    Golo Ahlenstiel
    Immunology Section, National Institute for Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1800, USA
    Gastroenterology 138:325-35.e1-2. 2010
    ....
  89. pmc The Yin and Yang of HLA and KIR in human disease
    Smita Kulkarni
    Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Semin Immunol 20:343-52. 2008
    ..Emerging functional data supports a mechanism based on a continuum of inhibition to activation through various compound KIR-HLA genotypes in diseases...
  90. ncbi Whatever turns you on: accessory-cell-dependent activation of NK cells by pathogens
    Kirsty C Newman
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Nat Rev Immunol 7:279-91. 2007
    ....
  91. ncbi Human diversity in killer cell inhibitory receptor genes
    M Uhrberg
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Immunity 7:753-63. 1997
    ..Group B comprises more noninhibitory KIR genes and contains at least one additional gene not represented in group A. The KIR locus therefore appears to be polygenic and polymorphic within the human population...
  92. ncbi Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts
    J Paloneva
    Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland
    Nat Genet 25:357-61. 2000
    ..No abnormalities in NK cell function were detected in PLOSL patients homozygous for a null allele of TYROBP...
  93. ncbi Immunology of placentation in eutherian mammals
    Ashley Moffett
    King s College, Cambridge CB2 1ST, UK
    Nat Rev Immunol 6:584-94. 2006
    ..At the implantation site, cells from the mother and the fetus intermingle during pregnancy. Unravelling what happens here is crucial to our understanding of why some human pregnancies are successful whereas others are not...
  94. pmc CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner
    Francois Ghiringhelli
    ERM 0208, Institut National de la Sante et de la Recherche Medicale INSERM, University of Paris XI, France
    J Exp Med 202:1075-85. 2005
    ..Human NK cell-mediated tumor recognition could also be restored by depletion of T reg cells from tumor-infiltrating lymphocytes. These findings support a role for T reg cells in blunting the NK cell arm of the innate immune system...
  95. ncbi T cell- and B cell-independent adaptive immunity mediated by natural killer cells
    Jacqueline G O'Leary
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:507-16. 2006
    ..No contact hypersensitivity was induced in mice lacking all lymphocytes, including natural killer cells. Contact hypersensitivity responses were acquired by such mice after adoptive transfer of natural killer ..
  96. ncbi Anti-myeloma activity of endogenous and adoptively transferred activated natural killer cells in experimental multiple myeloma model
    Evren Alici
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Exp Hematol 35:1839-46. 2007
    ....
  97. ncbi Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain
    X Cao
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    Immunity 2:223-38. 1995
    ..These mice provide an important model for studying the pathophysiology provide an important model for studying the pathophysiology of and gene therapy for human XSCID...
  98. pmc Central nervous system (CNS)-resident natural killer cells suppress Th17 responses and CNS autoimmune pathology
    Junwei Hao
    Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
    J Exp Med 207:1907-21. 2010
    ..Our studies suggest an organ-specific activity of NK cells on the magnitude of CNS inflammation, providing potential new targets for therapeutic intervention...
  99. ncbi Roles of the NKG2D immunoreceptor and its ligands
    David H Raulet
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, California 94720 3200, USA
    Nat Rev Immunol 3:781-90. 2003
    ....
  100. ncbi Natural killer cells and CD4+ T-cells modulate collateral artery development
    V van Weel
    Gaubius Laboratory, TNO QOL, P O Box 2215, 2301CE Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 27:2310-8. 2007
    ..Here, we studied the role of lymphocytes in a murine model of hindlimb ischemia...
  101. ncbi Education of human natural killer cells by activating killer cell immunoglobulin-like receptors
    Cyril Fauriat
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Blood 115:1166-74. 2010
    ..Our results provide the first example of human NK-cell education by an activating KIR and suggest that the education of NK cells via activating KIRs is a mechanism to secure tolerance that complements education via inhibitory KIRs...

Research Grants75

  1. FROM COLEY'S TOXINS TO CpG IMMUNOSTIMULANTS FOR CANCER *
    Anthony Sandler; Fiscal Year: 2004
    ..In addition to this systemic immunity, local immunity can be induced by direct activation of natural killer cells in the tumor bed...
  2. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..processes including angiogenesis, lymphocyte trafficking and the migration of hematopoietic stem cells, natural killer cells, and cancer cells...
  3. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..these pathogens and consists of numerous soluble factors and cell types, including dendritic cells (DC) and natural killer cells. One type of DC, the plasmacytoid DC (PDC) is important in innate immune function through the production of ..
  4. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010
    ..of the host immune response, including T and B cells, macrophages, dendritic cells, PMNs, mast cells, and natural killer cells. Thus, substance P may be important for the induction of the innate immune response and the initiation of ..
  5. Human Decidual Leukocytes and Their Placental Ligands
    JACK STROMINGER; Fiscal Year: 2009
    ..Decidual natural killer cells (50-90% of leukocytes in the decidua that were characterized during the first 5 years of this project) ..
  6. Role of interleukin-17 and iNKT cells in COPD
    ABDALA EL KHAL; Fiscal Year: 2010
    ..barrier and induces a migration of different cell type such as neutrophils, macropages, T lymphocytes and natural killer cells through the airway epithelium...
  7. ACTIVATION OF XENOGENEIC ENDOTHELIUM TO RESIST INJURY
    Agustin P Dalmasso; Fiscal Year: 2010
    ..protective molecules will be studied in protection from apoptosis elicited with TNF-alpha and with human natural killer cells. In these first three specific aims the protective pathways will be studied with kinase inhibitors and the ..
  8. Human Decidual Leukocytes and Their Placental Ligands
    Jack L Strominger; Fiscal Year: 2013
    ..Decidual natural killer cells (~70% of leukocytes in the decidua that were characterized during the first 5 years of this project) ..
  9. Origins of Diversity at Human Classical MHC Class I Genes
    PETER R PARHAM; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Natural killer cells are a population of lymphocytes that makes essential contributions to immune defense and placental ..
  10. Cannabinoid Epigenomic and miRNA mechanisms impact HIV/SIV disease progression
    Patricia E Molina; Fiscal Year: 2013
    ..receptor subtypes (CB1 and CB2) as well as their localization (CB2predominantly on B lymphocytes and natural killer cells) has resulted in identification of multisystemic biomedical effects...
  11. Human Population Diversity in Leukocyte Receptors
    PETER R PARHAM; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Natural killer cells fight viruses at early times of infection and also contribute to reproduction, by remodeling the mother&..
  12. Protective immunity against HIV: the role of IgG subclass and glycosylation
    Donald Forthal; Fiscal Year: 2009
    Project Summary Engagement of IgG Fc receptors (Fc?Rs) on natural killer cells, monocytes, macrophages, or dendritic cells may play a critical role in preventing lentivirus infection...
  13. Granzyme a Pathway of CTL-Mediated Cell Death
    Judy Lieberman; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cytotoxic T lymphocytes and natural killer cells release granzymes and perforin from cytotoxic granules into the immune synapse to induce apoptosis of virally infected or tumor targets...
  14. Material Fumonisin Exposure and Pregnancy Outcome: Decoding the Sphingolipid Immu
    Janee Gelineau van Waes; Fiscal Year: 2009
    ..The LM/Bc mouse has an altered innate immune response, and deficiencies in uterine natural killer cells (uNK)...
  15. Protein Carbohydrate Interactions in Cell Communication
    James C Paulson; Fiscal Year: 2010
    ..immunity, including C-type lectins, siglecs and the CD1 T-cell receptor in dendritic cells, macrophages, natural killer cells and other leukocytes, are being explored, as are aspects of cell signaling mediated by galectins, siglecs ..
  16. Role of fascin1 in dendritic cell-mediated immunity against listeria infection
    Shigeko Yamashiro; Fiscal Year: 2013
    ..Fascin1 is absent in immature DCs or in other blood cells including macrophages, neutrophils and natural killer cells, suggesting a specific role for fascin1 in DC biology upon maturation...
  17. Mapping the functional major histocompatibility complex genes in zebrafish
    JILL L DE JONG; Fiscal Year: 2012
    ..In addition, immunology experiments studying antigen presentation, activation of lymphocytes and natural killer cells, and infectious disease models in the zebrafish would become possible...
  18. T Cell Modulation by NKG2D
    Thomas Spies; Fiscal Year: 2013
    The NKG2D receptor triggers natural killer cells and costimulates T cells upon engagement of ligands that are absent from most normal cells but can be induced by cell stress...
  19. Cetuximab Therapy of Pancreatic Cancer: Immune Modulation with IL-21
    William E Carson; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The program seeks to generate pre-clinical data using in vitro studies with human natural killer cells and a murine tumor model to support the use of interleukin-21 and an anti-HER1 monoclonal antibody (..
  20. Targeting the COX-2 Pathway to Reduce Breast Cancer Mortality
    Amy M Fulton; Fiscal Year: 2012
    ..Furthermore, that EP1 controls metastasis by a mechanism dependent on Natural Killer cells. We will carry out the following Specific Objectives to test these hypotheses: Using a unique collection of ..
  21. NK Cell Control of Acute Influenza Virus Infection
    Jonathan W Heusel; Fiscal Year: 2010
    ..Finally, the findings will impact the design of new vaccination strategies in order to exploit the contributions from natural killer cells.
  22. AvanceIII 700MHz NMR spectrometer with cryogenic probe
    James J Chou; Fiscal Year: 2010
    ..regions of immunoreceptors, by solving the structure of an activating immune receptor complex from the Natural Killer cells, consisting of the transmembrane domains of the dimeric DAP12 signaling module and the NKG2C receptor chain...
  23. The Role of RNA Interference in West Nile Virus Diversification
    Douglas E Brackney; Fiscal Year: 2010
    ..Vertebrates respond to viral infections mainly via type-1 interferon and natural killer cells, whereas mosquitoes rely on RNA interference (RNAi) as an intracellular defense mechanism to control viral ..
  24. Innate Immune Recognition and Type I IFN Response to Cytosolic Pathogens
    KELLY M STOREK; Fiscal Year: 2013
    ..including antigen presentation and production of cytokines involved in activation of T cells, B cells and natural killer cells. While type I IFN signaling is increasingly appreciated as an important host defense mechanism against ..
  25. ER PROTEINS EFFECT ON CLASS I MHC ASSEMBLY
    Joyce Solheim; Fiscal Year: 2009
    ..In addition, the number of surface MHC class I molecules on target cells influences their recognition by natural killer cells. For all these reasons, cell surface expression of peptide-bearing MHC class I molecules is of ..
  26. Elucidating mechanisms governing transcriptional regulation of the human LAT gene
    Timothy S Finco; Fiscal Year: 2013
    ..highly conserved among mammals, is critical for the development and/or function of T cells, mast cells, Natural Killer cells, and megakaryocytes/platelets...
  27. Anti-HIV Neuroimmunomodulatory Therapy with Neurokinin-1 (NK1-R) Antagonists
    STEVEN DANIEL DOUGLAS; Fiscal Year: 2013
    ..This NK1RA has activity as an antiviral HIV agent that improves innate immunity (Natural Killer cells) and has positive neurobehavioral effects. NK1RA are a potential novel therapy for neuroAIDS.
  28. DEVELOPMENT AND FUNCTION OF INTESTINAL LYMPHOID TISSUES
    Rodney D Newberry; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: During intestinal inflammation a unique population of natural killer cells are generated...
  29. Integrin-Mediated Matrix Signaling in Liver Fibrosis
    Lester F Lau; Fiscal Year: 2013
    ..The senescent stellate cells express anti-fibrotic genes and are targeted for removal by natural killer cells, thereby limiting fibrosis and facilitating resolution of the healing response...
  30. Positive and Negative Regulation of Natural Killer Cells After BMT
    WILLIAM JOSEPH MURPHY; Fiscal Year: 2013
    ....
  31. Returning to the workforce supplement request for R01 GM095638
    Jennifer A Maynard; Fiscal Year: 2013
    ..As a part of innate immunity, these processed peptides are presented on cell surfaces for recognition by Natural Killer cells to indicate that the cell is healthy...
  32. 13th International Meeting of the Society for Natural Immunity April 20-24, 2012
    Lewis L Lanier; Fiscal Year: 2012
    ..underrepresented minorities to attend a four-day international scientific meeting devoted to the study of natural killer Cells (NK cells)...
  33. NK Cells in GVHD and GVT
    Robert S Negrin; Fiscal Year: 2012
    ..further our understanding of the immunobiology of hematopoietic cell transplantation through the study of natural killer cells which have the unique capabilities of improving anti-tumor effects without causing graft vs host disease...
  34. Psychogenetic Factors in Project REACH
    Nicole R Nugent; Fiscal Year: 2013
    ..g., CD4/CD8 lymphocytes, HIV-1 plasma RNA levels, cytokines, and natural killer cells) in youth living with HIV (YLH)...
  35. DEK and TNF inhibitors in juvenile arthritis
    DAVID MICHAEL MARKOVITZ; Fiscal Year: 2012
    ..cells and released by apoptotic T cells, and serve as a chemoattractant for neutrophils, CD8+ T cells, and natural killer cells. As DEK expression has been found to be stimulated by TNF, and we can inhibit DEK secretion with TNF ..
  36. Flt3L Treatment of Pancreatic Cancer
    Joyce C Solheim; Fiscal Year: 2013
    ..cytokine Flt3L preferentially expands DC1 cells and increases the type 1 T cell response and the numbers of natural killer cells, and it has been shown to have an immunologically mediated anti-tumor effect in several cancer models...
  37. Generation of Ikaros conditional knockout mice
    SUSAN M WINANDY; Fiscal Year: 2012
    ..Defects in Ikaros null mice include a total lack of B and natural killer cells, selective lack of some lineages of dendritic and ?dT cells and defects in a[unreadable]T cell development...
  38. HLA and KIR Genomics in Inflammatory Bowel Disease
    Elizabeth A Trachtenberg; Fiscal Year: 2013
    ..medically refractory UC). The contribution of the natural killer cells (NK) in innate immunity to the risk of IBD has not been as well examined...
  39. REGULATION OF VIRAL-INDUCED NK CELL PROLIFERATION DURING MURINE CMV INFECTION
    Anthony R French; Fiscal Year: 2013
    ..studies is to understand the regulation of one important type of cell in our innate immune response, natural killer cells, during viral infections...
  40. Regulation of Mucosal Immune Responses by the TNF Receptor HVEM
    Mitchell Kronenberg; Fiscal Year: 2013
    ..responses are impaired in Hvem-/- mice, including decreased IL-22 production by specialized intestinal natural killer cells (NK22 cells) and decreased generation of IL-17 secreting T lymphocytes (Th17 cells)...
  41. Immunomodulatory mechanism of volatile anesthetics
    Koichi Yuki; Fiscal Year: 2013
    ..playing a role in leukocyte arrest on the endothelium, phagocytosis, immunological synapse formation, natural killer cells cytotoxicity, and so on...
  42. Small Molecule Antibody Mimics: Toward a New Paradigm in Targeted Cancer Therapy
    David A Spiegel; Fiscal Year: 2013
    ..g., natural killer cells, macrophages, and dendritic cells)...
  43. Phase 1 Study of Interleukin-2 in Wiskott-Aldrich Syndrome
    Soma Jyonouchi; Fiscal Year: 2013
    ..In the absence of the actin branching protein WASp, natural killer cells do not properly form immunologic synapses with target cells, which limits their cytotoxic function...
  44. COBRE for Perinatal Biology
    James F Padbury; Fiscal Year: 2012
    ..stem cell repair of cardiac injury in adult life;5) the immunopathogenesis of preeclampsia;6) role of natural killer cells in successful pregnancy outcomes...
  45. Effects of chronic alcohol consumption on pathogenesis of respiratory viral infec
    THOMAS JERRELLS; Fiscal Year: 2009
    ..limit early control of viral infection by suppressing activation of natural killer cells, which limits production of interferon (IFN)-. B...
  46. Characterization of Antibody-Dependent Cellular Cytotoxicity in HIV Infection
    ADJOA R SMALLS-MANTEY; Fiscal Year: 2013
    ..viral epitopes coating an infected CD4+ target T cell and an Fc receptor bearing effector, most commonly natural killer cells (NKs), bind the Ab and use perforin to deliver granzymes which induce apoptosis in the target...
  47. Chemerin in Tumor Immunity and Surveillance
    Eugene C Butcher; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Tumorigenesis is controlled by mechanisms of immune surveillance. Natural killer cells are important mediators of innate anti-tumor immunity, and immunostimulatory dendritic cells and cytotoxic T ..
  48. Molecular Mechanisms of HIV Disease Pathogenesis
    Kathleen L Collins; Fiscal Year: 2013
    ..antiviral factor that inactivates the virus by converting cytosine residues to uracils, also alerts natural killer cells to the infection. HIV counteracts this cellular response via the concerted activities of Vif, Vpr and Nef...
  49. Adoptive Immunotherapy of Cancer with IL-12 Secreting Tumor-Targeted T cells
    RENIER JOSEPH BRENTJENS; Fiscal Year: 2013
    ..IL-12 secretion by targeted T cells will recruit or activate other host immune elements, including natural killer cells as well as anergic TILs, thereby broadening the anti-tumor immune repertoire...
  50. Innate Immunity and Cancer Therapy
    SARAH ANNE COOLEY; Fiscal Year: 2011
    ..and evidence suggests that at least part of the efficacy is mediated through the indirect activation of natural killer cells. Increased appreciation for the role of killer immunoglobulin-like receptors (KIR) in mediating NK cell ..
  51. Natural Killer Cell Receptor Diversity and CMV in Hematopoietic Cell Transplantat
    STEVEN AARON PERGAM; Fiscal Year: 2013
    ..In addition, our data suggests that fewer cytotoxic CD56[unreadable]"/KIR* natural killer cells in the post-HCT period increase the risk of CMV reactivation...
  52. CONTROLLING NK CELL ANTI-CANCER ACTIVITY: THE ROLE OF NUTRIENTS AND SUPPLEMENTS
    Marco Colonna; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Natural killer cells are generally viewed as a first line of defense in cancer immunosurveillance and are critical players in immune-mediated cancer rejection...
  53. Mechanisms of Innate Immune Memory
    MEGAN ANNE COOPER; Fiscal Year: 2013
    ..b>Natural killer cells are a key component of the innate immune response and provide protection against a variety of infections...
  54. Activation of Plasmacytoid Dendritic Cells (pDCs) to Induce Antitumor Activity
    Patrick Hwu; Fiscal Year: 2012
    ..viruses and lead directly to the activation of other immune cells, including myeloid dendritic cells and natural killer cells which then lead to a potent adaptive T-cell immune response...
  55. ACTIN AND MICROTUBULE-BASED MECHANISMS FOR FUNCTIONS OF NK LYMPHOID CELLS
    John A Cooper; Fiscal Year: 2013
    ..This research will help us understand the molecular mechanisms by which certain lymphocytes, called Natural Killer cells, are able to find and kill cancer cells and virus-infected cells...
  56. Synthetic immunoreceptor systems for combinatorial tumor antigen detection
    Chia Yung Wu; Fiscal Year: 2013
    ..2) Compare the properties of the developed CAR systems in both T cells and Natural Killer cells, two major types of immune cells that are therapeutically useful in adoptive immunotherapy...
  57. LIVER-RESIDENT NATURAL KILLER CELLS, VIRAL INFECTION, HEPATITIS AND MEMORY
    Wayne M Yokoyama; Fiscal Year: 2013
    ..Thus, the proposed studies wil provide novel insight into the role of liver-resident NK cells in host immune defense. ..
  58. RECEPTOR AGGREGATION AND ITS EFFECTS
    BYRON B GOLDSTEIN; Fiscal Year: 2012
    ..FcyRllb which, when co-crosslinked with FceRI, acts as an inhibitory receptor and FcyRllla, the receptor on Natural Killer cells that mediates antibody-dependent cell-mediated cytotoxicity...
  59. Modulation of surface markers by HIV-1 Vpu/Vpr and sensitivity to NK cell lysis
    VICENTE contact PLANELLES; Fiscal Year: 2010
    ..b>Natural killer cells have the ability to recognize virally infected cells and induce their death via a lytic mechanism, ..
  60. Biochemical Characterization of the Regulatory T-cell Protein LAG-3.
    Zarixia Zavala Ruiz; Fiscal Year: 2010
    ..This protein is expressed in activated natural killer cells, CD4+ and CD8+ T-cells. B-cells also express LAG-3 in a T-cell dependent manner...
  61. Anti-viral DC/NK interactions
    CHRISTIAN MUNZ; Fiscal Year: 2012
    ..This proposal plans to investigate how two cell types of the innate immune system, dendritic cells and Natural Killer cells, interact to initially control EBV and influence other immune cells to establish life-long protection from ..
  62. The function and regulation of histocompatibility antigen 60 in cancer
    Jack D Bui; Fiscal Year: 2012
    ..The interferon treatment is expected to inhibit tumor surveillance by natural killer cells only in cell lines that express H60...
  63. Neutralizing and non-neutralizing antibodies protection from breast milk HIV-1
    Manish Sagar; Fiscal Year: 2013
    ..On the other hand, immune effector cells, such as natural killer cells, may eliminate maternal breast milk cell free viruses and infected cells through antibody dependent ..
  64. MACROPHAGE/NEUTROPHIL ELASTASE INHIBITOR
    EILEEN REMOLD O DONNELL; Fiscal Year: 1999
    ..and ELISA of monocyte/macrophage and neutrophil lineage cells and also cytolytic T- lymphocytes and natural killer cells, all of which contain active serine proteases...
  65. Liver innate immunity in drug-induced liver disease
    Zhang Xu Liu; Fiscal Year: 2006
    ..The abundance of natural killer cells (NK) and NK cells with T cell receptors (NKT) in the liver raises the question as to what may be the role ..
  66. CANCER PATIENTS IMMUNE RESPONSES STUDIED IN SCID MICE
    Dorothee Herlyn; Fiscal Year: 1992
    ..The determined and functional activities of the TIL (cytolytic T lymphocytes, and lymphokine- activated or natural killer cells) will be characterized...
  67. IL15 AND NATURAL KILLER (NK) CELL FUNCTION
    William Carson; Fiscal Year: 1999
    ..Macrophages and natural killer cells comprise an important arm of the innate immune system and do not require prior sensitization or recognition ..
  68. Hemostatic Factors and Tumor Biology
    Joseph Palumbo; Fiscal Year: 2007
    ..is an important determinant of metastatic potential, possibly by influencing tumor cell clearance by natural killer cells. However, the precise mechanism(s) by which the platelet/fibrinogen axis influences malignancy remain ..
  69. MASSAGE THERAPY FOR PATIENTS WITH HIV-1
    Thomas Birk; Fiscal Year: 1993
    ..in combination with one antiretroviral medication will improve the immune system as measured by CD4, natural killer cells and interferon alpha levels in persons with advanced HIV...
  70. Novel Immunotoxins for Depletion of Dendritic Cells
    Warren Shlomchik; Fiscal Year: 2005
    ..GVHD requires functional host antigen presenting cells (APCs) and that their depletion with alloreactive natural killer cells prevents GVHD in both mice and humans. This represents a novel form of GVHD prevention and treatment...
  71. EXPRESSION & FUNCTION OF HLA ANTIGEN ON CARDIAC MYOCYTES
    Aftab Ansari; Fiscal Year: 1990
    ..Thus, helper T cells (CD4+), cytotoxic T cells (CD8+) and natural killer cells have all been implicated...
  72. NK AND T-CELL DEVELOPMENT FROM HEMATOPOIETIC STEM CELLS
    Jeffrey Miller; Fiscal Year: 1999
    ..can give rise not only to myeloid progenitors in long-term bone marrow culture (LTBMC), but to natural killer cells (NK) after coculture in direct contact with bone marrow stroma...
  73. The role of macrophages and natural killer cells in cisplatin-induced acute renal
    Lawrence Lu; Fiscal Year: 2007
    ..Better understanding of the underlying inflammatory mechanisms may lead to improved preventative and treatment strategies. [unreadable] [unreadable] [unreadable]..
  74. Immune dysregulation by psychosocial distress
    HERBERT MATHEWS; Fiscal Year: 2006
    ..Psychosocial distress impairs the immune system, impacting both natural killer cells and the production of cytokines...
  75. Development and evaluation of a novel SOCS1-silenced HIV vaccine
    Jerry Blackwell; Fiscal Year: 2009
    ..cytokines, resulting in the enhancement of memory, antigen-specific T- and B- cell responses and activated natural killer cells. Herein we hypothesize that the immunogenicity of an adenovirus (Ad)-based HIV vaccine will be enhanced by ..