lymphocyte subsets

Summary

Summary: A classification of lymphocytes based on structurally or functionally different populations of cells.

Top Publications

  1. ncbi Lymphocyte numbers and subsets in the human blood. Do they mirror the situation in all organs?
    Katrin S Blum
    Department of Functional and Applied Anatomy 4120, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Immunol Lett 108:45-51. 2007
  2. ncbi Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
    Subhra K Biswas
    Singapore Immunology Network, Agency for Science, Technology and Research, Singapore
    Nat Immunol 11:889-96. 2010
  3. ncbi CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity
    Todd A Fehniger
    Department of Internal Medicine, Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
    Blood 101:3052-7. 2003
  4. ncbi TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    Marc Veldhoen
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Immunity 24:179-89. 2006
  5. ncbi CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity
    Yoshihiro Hayakawa
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Immunol 176:1517-24. 2006
  6. pmc Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis
    Bibiana Bielekova
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:5941-6. 2006
  7. pmc CD56bright natural killer (NK) cells: an important NK cell subset
    Aurélie Poli
    Laboratoire d Immunogénétique Allergologie, Centre de Recherche Public de la Santé, Luxembourg City, Luxembourg
    Immunology 126:458-65. 2009
  8. ncbi A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127
    Christian A J Vosshenrich
    Unité des Cytokines et Développement Lymphoide, Institut National de la Santé et de la Recherche Médicale U668, Institut Pasteur, Paris F 75724, France
    Nat Immunol 7:1217-24. 2006
  9. ncbi Mesenchymal stromal cells use PGE2 to modulate activation and proliferation of lymphocyte subsets: Combined comparison of adipose tissue, Wharton's Jelly and bone marrow sources
    Mehdi Najar
    Laboratory of Experimental Hematology, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium
    Cell Immunol 264:171-9. 2010
  10. pmc Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients
    Laszlo G Radvanyi
    Departments of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 18:6758-70. 2012

Detail Information

Publications331 found, 100 shown here

  1. ncbi Lymphocyte numbers and subsets in the human blood. Do they mirror the situation in all organs?
    Katrin S Blum
    Department of Functional and Applied Anatomy 4120, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Immunol Lett 108:45-51. 2007
    ..Several studies have documented the normal ranges of lymphocytes and lymphocyte subsets in the peripheral blood...
  2. ncbi Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
    Subhra K Biswas
    Singapore Immunology Network, Agency for Science, Technology and Research, Singapore
    Nat Immunol 11:889-96. 2010
    ..In response to innate recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive responses...
  3. ncbi CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity
    Todd A Fehniger
    Department of Internal Medicine, Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
    Blood 101:3052-7. 2003
    ..These data show a dynamic interaction between innate and adaptive human lymphocytes and emphasize the importance of studying interactions between immune components to understand the immune response as a whole...
  4. ncbi TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    Marc Veldhoen
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Immunity 24:179-89. 2006
    ..Our data indicate that, in the presence of IL-6, TGFbeta1 subverts Th1 and Th2 differentiation for the generation of IL-17-producing T cells...
  5. ncbi CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity
    Yoshihiro Hayakawa
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Immunol 176:1517-24. 2006
    ..These findings clearly reclassify mature NK cells into two distinct subsets and begin to discern their specific role in immune responses...
  6. pmc Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis
    Bibiana Bielekova
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:5941-6. 2006
    ..This immunoregulation has potential importance for the treatment of autoimmune diseases and transplant rejection and toward modification of tumor immunity...
  7. pmc CD56bright natural killer (NK) cells: an important NK cell subset
    Aurélie Poli
    Laboratoire d Immunogénétique Allergologie, Centre de Recherche Public de la Santé, Luxembourg City, Luxembourg
    Immunology 126:458-65. 2009
    ..CD56(bright) NK cell percentages are expanded or reduced in a certain number of diseases, but the significance of these variations is not yet clear...
  8. ncbi A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127
    Christian A J Vosshenrich
    Unité des Cytokines et Développement Lymphoide, Institut National de la Santé et de la Recherche Médicale U668, Institut Pasteur, Paris F 75724, France
    Nat Immunol 7:1217-24. 2006
    ..We propose that bone marrow and thymic NK cell pathways generate distinct mouse NK cells with properties similar to those of the two human CD56 NK cell subsets...
  9. ncbi Mesenchymal stromal cells use PGE2 to modulate activation and proliferation of lymphocyte subsets: Combined comparison of adipose tissue, Wharton's Jelly and bone marrow sources
    Mehdi Najar
    Laboratory of Experimental Hematology, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium
    Cell Immunol 264:171-9. 2010
    ..CD4(+) and CD8(+) T-lymphocytes were equally targeted by MSCs demonstrating that the immunomodulation was not restricted to a specific T-cell subpopulation...
  10. pmc Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients
    Laszlo G Radvanyi
    Departments of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 18:6758-70. 2012
    ....
  11. ncbi NK and T cells constitute two major, functionally distinct intestinal epithelial lymphocyte subsets in the chicken
    T W Göbel
    Institute for Animal Physiology, Veterinarstrasse 13, 80539 Munich, Germany
    Int Immunol 13:757-62. 2001
    ..These results define two major, phenotypically and functionally distinct IEL subpopulations, and imply an important role of NK cells in the mucosal immune system...
  12. ncbi Lymphocyte subsets in healthy children from birth through 18 years of age: the Pediatric AIDS Clinical Trials Group P1009 study
    William T Shearer
    Baylor College of Medicine, Houston, Tex, USA
    J Allergy Clin Immunol 112:973-80. 2003
    Peripheral blood lymphocyte subsets need to be determined in a large, urban, minority-predominant cohort of healthy children to serve as suitable control subjects for the interpretation of the appearance of these cells in several disease ..
  13. ncbi The biology of human natural killer-cell subsets
    M A Cooper
    Dept of Veterinary Biosciences and Comprehensive Cancer Center, The Ohio State University, 458A Starling-Loving Hall, 320 West 10th Ave, Columbus, OH 43210, USA
    Trends Immunol 22:633-40. 2001
    ..In addition, we will discuss other cell-surface receptors expressed differentially by human NK-cell subsets and the distinct functional properties of these subsets...
  14. pmc Characterization of peripheral blood lymphocyte subsets in patients with acute Plasmodium falciparum and P. vivax malaria infections at Wonji Sugar Estate, Ethiopia
    Desta Kassa
    Ethiopian Health and Nutrition Research Institute EHNRI, P O Box 1242, Addis Ababa, Ethiopia
    Clin Vaccine Immunol 13:376-9. 2006
    ..Thus, special steps should be taken in dealing with malaria patients, including enumeration of peripheral lymphocyte cells for diagnostic purposes and research on peripheral blood to evaluate the immune status of patients...
  15. ncbi Evidence for NK cell subsets based on chemokine receptor expression
    Robert D Berahovich
    ChemoCentryx, 850 Maude Avenue, Mountain View, CA 94043, USA
    J Immunol 177:7833-40. 2006
    ..These results indicate that within both the CD56(bright) and CD56(dim) NK cell populations, subsets with the capacity for differential trafficking programs exist, which likely influence their functions in innate and adaptive immunity...
  16. ncbi Natural killer cells and viral infections
    Anthony R French
    Howard Hughes Medical Institute, Rheumatology Division, Box 8045, Washington University Medical Center, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Curr Opin Immunol 15:45-51. 2003
  17. pmc Lymphocyte subsets in term and significantly preterm UK infants in the first year of life analysed by single platform flow cytometry
    J E Berrington
    Department of Neonatology, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Clin Exp Immunol 140:289-92. 2005
    This observational study describes the ranges observed for lymphocyte subsets for significantly preterm infants (<32 weeks) in the first year of life, measured by single platform flow cytometry and compared to identically determined ..
  18. ncbi The relationship of depression and stressors to immunological assays: a meta-analytic review
    E P Zorrilla
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Brain Behav Immun 15:199-226. 2001
    ..The implications for these findings for disease susceptibility and the pathophysiology of these conditions is discussed...
  19. ncbi CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation
    Nicola Dalbeth
    Division of Medicine, Imperial College London, Commonwealth Building, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    J Immunol 173:6418-26. 2004
    ..Such a positive feedback loop is likely to be important in the pathogenesis of chronic inflammatory conditions such as rheumatoid arthritis...
  20. ncbi Evaluation of the effect of selective serotonin-reuptake inhibitors on lymphocyte subsets in patients with a major depressive disorder
    Maria Eugenia Hernandez
    Department of Psychoimmunology, National Institute of Psychiatry Ramon de la Fuente, Mexico
    Eur Neuropsychopharmacol 20:88-95. 2010
    ..was to determine the effect of a 52-week long treatment with selective serotonin-reuptake inhibitors on lymphocyte subsets. The participants were thirty-one patients and twenty-two healthy volunteers...
  21. pmc Occupational exposure to formaldehyde and alterations in lymphocyte subsets
    H Dean Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7240, USA
    Am J Ind Med 56:252-7. 2013
    ..Formaldehyde is used in many occupational settings, most notably in manufacturing, health care, and embalming. Formaldehyde has been classified as a human carcinogen, but its mechanism of action remains uncertain...
  22. ncbi Tumor-associated macrophages in pediatric classical Hodgkin lymphoma: association with Epstein-Barr virus, lymphocyte subsets, and prognostic impact
    Mario Henrique M Barros
    Institute for Pathology, Unfallkrankenhaus Berlin, Berlin, Germany
    Clin Cancer Res 18:3762-71. 2012
    ..We have previously shown age-related changes in the lymphocyte composition of pediatric cHL. We therefore hypothesized that the number, function, and prognostic impact of macrophages in pediatric cHL would be different from adult cases...
  23. ncbi Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2
    Y Yokota
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Nature 397:702-6. 1999
    ..Our results indicate that Id2 has an essential role in the generation of peripheral lymphoid organs and NK cells...
  24. pmc The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway
    Lucille C Rankin
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Nat Immunol 14:389-95. 2013
    ..Our results pinpoint the regulation of Notch signaling by T-bet as a distinct molecular pathway that guides the development of NKp46+ ILCs...
  25. ncbi Associations between infiltrating lymphocyte subsets and hepatocellular carcinoma
    Cun Li Guo
    The Third Hospital of Harbin Medical University, Harbin, China
    Asian Pac J Cancer Prev 13:5909-13. 2012
    ..We aimed to analyze the phenotype of tumor-infiltrating lymphocytes (TILs) and non-tumor infiltrating lymphocytes (NILs) in HCC and non-tumor tissues, and evaluate relationships between changes in these cells and the prognosis of HCC...
  26. ncbi M-DC8+ leukocytes--a novel human dendritic cell population
    K Schakel
    Institute for Immunology, Medical Faculty, University of Dresden, Germany
    Pathobiology 67:287-90. 1999
    ..The mAb M-DC8 might thus be a valuable tool to determine circulating DC for diagnostic purposes and to isolate these cells for studies of antigen-specific T cell priming...
  27. pmc Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation
    Gurumoorthy Krishnamoorthy
    Department of Neuroimmunology, Max Planck Institute for Neurobiology, Martinsried, Germany
    J Clin Invest 116:2385-92. 2006
    ..In addition, in OSE mice, but not in single-transgenic parental mice, anti-MOG antibodies were switched from IgM to IgG1...
  28. pmc Cutting edge: Natural helper cells derive from lymphoid progenitors
    Qi Yang
    Department of Pathology, Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 187:5505-9. 2011
    ..This work therefore expands the lymphocyte family, currently comprising T, B, and NK cells, to include NH cells as another type of innate lymphocyte that derives from bone marrow lymphoid progenitors...
  29. ncbi Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21
    Kim L Good
    Centenary Institute of Cancer Medicine and Cell Biology, New South Wales, Australia
    J Immunol 177:5236-47. 2006
    ..Thus, antagonizing IL-21 may be a novel strategy for treating Ab-mediated autoimmune diseases...
  30. pmc Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence
    Till Strowig
    Laboratory of Viral Immunobiology, and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY, USA
    Blood 116:4158-67. 2010
    ..These data suggest that a functional, but resting, NK-cell compartment can be established in immune-compromised mice after human hematopoietic progenitor cell transfer...
  31. ncbi IRF family of transcription factors as regulators of host defense
    T Taniguchi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Annu Rev Immunol 19:623-55. 2001
    ..Their functional roles, through interactions with their own or other members of the family of transcription factors, are becoming clearer in the regulation of host defense, such as innate and adaptive immune responses and oncogenesis...
  32. pmc In vivo instruction of suppressor commitment in naive T cells
    Irina Apostolou
    Dana Farber Cancer Institute, Harvard Medical School, 44 Binney St, Boston, MA 02115, USA
    J Exp Med 199:1401-8. 2004
    ....
  33. ncbi Lymphocyte subsets' reference ranges in an age- and gender-balanced population of 100 healthy adults--a monocentric German study
    Kathleen Jentsch-Ullrich
    Department of Haematology Oncology, Medical Faculty, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
    Clin Immunol 116:192-7. 2005
    Region-specific reference ranges for adult peripheral blood lymphocyte subsets have been established in few countries around the world, but most studies were restricted to younger adults for monitoring of HIV patients...
  34. ncbi Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death
    Benedikt Fritzsching
    Department of Neonatology, Children s Hospital, University of Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Blood 108:3371-8. 2006
    ..This new observation could be crucial for the planning of therapeutic application of T(regs)...
  35. ncbi Human NK cells display major phenotypic and functional changes over the life span
    Magali Le Garff-Tavernier
    INSERM, UMR S 945, F 75013, Paris, France
    Aging Cell 9:527-35. 2010
    ..We conclude that the preservation of NK cell features until very advanced age may contribute to longevity and successful aging...
  36. ncbi Alloreactivity and anti-tumor activity segregate within two distinct subsets of cytokine-induced killer (CIK) cells: implications for their infusion across major HLA barriers
    Dario Sangiolo
    Department of Oncological Sciences, University of Torino Medical School, Torino, Italy
    Int Immunol 20:841-8. 2008
    ..Engrafted patients after HCT could also be considered as an effective alternative option to donor-derived CIK cells...
  37. ncbi Specific and nonspecific NK cell activation during virus infection
    A O Dokun
    Howard Hughes Medical Institute, Rheumatology Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
    Nat Immunol 2:951-6. 2001
    ..These findings indicated that Ly49H+ NK cells were specifically activated by MCMV and that MCMV infection was characterized by nonspecific and specific phases of NK cell activation in vivo...
  38. ncbi Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians
    Yi Jiang
    Department of Epidemiology and International Health, School of Public Health, University of Alabama, Birmingham, AL 35294, USA
    Int Immunol 17:807-14. 2005
    ..330, P = 0.032) and AFB1 levels. These alterations in immunological parameters in participants with high AFB1 levels could result in impairments in cellular immunity that could decrease host resistance to infections...
  39. pmc 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7
    J J Campbell
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University Medical School, Stanford, California 94305, USA
    J Cell Biol 141:1053-9. 1998
    ....
  40. pmc Stage-specific immune responses in human Necator americanus infection
    S M Geiger
    Fundacao Oswaldo Cruz, Centro de Pesquisas Rene Rachou, Belo Horizonte MG, Brazil
    Parasite Immunol 29:347-58. 2007
    ..We propose that the longevity of hookworms in their human hosts results from a stage-specific, down-modulation of the immune response...
  41. ncbi Distinct categories of immunologic changes in frail elderly
    J L Fahey
    Center for Interdisciplinary Research in Immunology and Disease CIRID and the UCLA AIDS Institute and Department of Microbiology and Immunology, UCLA School of Medicine, 90095 1747, Los Angeles, CA, USA
    Mech Ageing Dev 115:1-20. 2000
    ..These findings emphasize that several different groups of immune parameters but not 33 independent immune changes, occurred in the aged population...
  42. ncbi Invariant NKT cells from HIV-1 or Mycobacterium tuberculosis-infected patients express an activated phenotype
    Carlos J Montoya
    Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL, USA
    Clin Immunol 127:1-6. 2008
    ..These findings indicate that peripheral blood iNKT cells in these two chronic infections show an up-regulated expression of activation markers, suggesting their role in the immune response to infection...
  43. ncbi Lymphocyte subsets and their H2AX phosphorylation in response to in vivo irradiation in rats
    Lenka Zarybnicka
    Department of Radiobiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
    Int J Radiat Biol 89:110-7. 2013
    The objective of the study was to investigate differences in the radiosensitivity of rat peripheral blood lymphocyte subsets identified by expression of surface clusters of differentiation markers (CD3, CD4, CD8, CD45RA, CD161) after ..
  44. pmc NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs
    Vivien Beziat
    INSERM UMR S 945, Hopital Pitie Salpetriere, and Université Pierre et Marie Curie Paris 6, Paris, France
    PLoS ONE 5:e11966. 2010
    ....
  45. ncbi Distribution of lymphocyte subsets in the small intestine lymphoid tissue of 1-month-old lambs
    J M Corpa
    , Facultad de Veterinaria, , Campus de Vegazana s/n, , Spain
    Anat Histol Embryol 30:121-7. 2001
    ..Lymphocytes positive to the B marker employed were located mainly in the centre, suggesting that both antibodies would mark B cells in different maturation status...
  46. pmc Effect of α4β7 blockade on intestinal lymphocyte subsets and lymphoid tissue development
    Caihong Wang
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Inflamm Bowel Dis 16:1751-62. 2010
    ....
  47. ncbi Lymphocyte subset analyses in healthy adults vaccinated with yellow fever 17DD virus
    Ana Paula dos Santos
    Laboratório de Tecnologia Imunológica, Bio Manguinhos, FIOCRUZ, 21045 900 Rio de Janeiro, RJ, Brazil
    Mem Inst Oswaldo Cruz 100:331-7. 2005
    ..All lymphocyte subsets analyzed were augmented around the 30th post vaccination day, both for first-time vaccinees and re-vaccinees...
  48. ncbi Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity
    S Brian Wilson
    Diabetes Laboratories, Massachusetts General Hospital, 65 Landsdowne Street, Room 525, Cambridge, Massachusetts 02138, USA
    Nat Rev Immunol 3:211-22. 2003
    ..The ability to modulate iNKT-cell activity in vivo using the ligand alpha-galactosylceramide and to treat patients with autoimmune disease or cancer is evaluated also...
  49. ncbi Lymphocyte subsets in lung tissues of interstitial pneumonia associated with untreated polymyositis/dermatomyositis
    I Yamadori
    Department of Clinical Pathology, National Okayama Medical Center, Japan
    Rheumatol Int 21:89-93. 2001
    This study was designed to evaluate the distribution of lymphocyte subsets in lung specimens obtained by surgical lung biopsy from 12 patients with interstitial pneumonia associated with untreated polymyositis/dermatomyositis (PM/DM)...
  50. ncbi Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells
    R E Mebius
    Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Immunity 7:493-504. 1997
    ..Since the necessity of lymphotoxin in lymphoid organ development has been shown, we propose that the novel subset of CD4+CD3-LTbeta+ fetal cells is instrumental in the development of lymphoid tissue architecture...
  51. ncbi Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion
    T Imai
    Shionogi Institute for Medical Science, Settsu, Japan
    Cell 91:521-30. 1997
    ..Thus, fractalkine and CX3CR1 represent new types of leukocyte trafficking regulators, performing both adhesive and chemotactic functions...
  52. pmc Reference values of lymphocyte subsets in healthy, HIV-negative children in Cameroon
    Bertrand Sagnia
    Chantal BIYA International Reference Centre for Research on HIV AIDS Prevention and Management CIRCB, BP 3077, Messa Yaounde, Cameroon
    Clin Vaccine Immunol 18:790-5. 2011
    ..We evaluated about 23 different lymphocyte subsets in which the absolute number and percentage values differed significantly (P < 0...
  53. ncbi Modulating effects of nonselective and selective phosphodiesterase inhibitors on lymphocyte subsets and humoral immune response in mice
    Marianna Szczypka
    Department of Biochemistry, Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Norwida 31, PL 50 375 Wrocław, Poland
    Pharmacol Rep 62:1148-58. 2010
    ..PDE3 inhibitor, sildenafil, a selective PDE5 inhibitor, and aminophylline, a nonselective PDE inhibitor, on lymphocyte subsets and humoral immune response in mice when administered in vivo. Aminophylline (20 mg/kg, i.m...
  54. pmc Occupational exposure to trichloroethylene is associated with a decline in lymphocyte subsets and soluble CD27 and CD30 markers
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Carcinogenesis 31:1592-6. 2010
    ..2 (36.0) p.p.m. The total lymphocyte count and each of the major lymphocyte subsets including CD4+ T cells, CD8+ T cells, natural killer (NK) cells and B cells were significantly decreased ..
  55. pmc Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinct
    Ellen F Young
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7290, USA
    Autoimmunity 42:678-91. 2009
    ..We conclude the underlying immunological processes in both male and female NOD mice are similar while the rates differ and the presence of naïve T cell in the islets may contribute to epitope spreading...
  56. ncbi Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
    S Bauer
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Science 285:727-9. 1999
    ..These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses...
  57. ncbi Lineage relationship analysis of RORgammat+ innate lymphoid cells
    Shinichiro Sawa
    Lymphoid Tissue Development Unit, Institut Pasteur, 75724 Paris, France
    Science 330:665-9. 2010
    ..Contrary to RORγt(+) T cells, however, RORγt(+) ILCs develop in the absence of microbiota. Our study indicates that RORγt(+) ILCs evolve to preempt intestinal colonization by microbial symbionts...
  58. ncbi Final steps of natural killer cell maturation: a model for type 1-type 2 differentiation?
    M J Loza
    Kimmel Cancer Center, Jefferson Medical College, Department of Microbiology and Immunology, Philadelphia, PA, USA
    Nat Immunol 2:917-24. 2001
    ..We propose that the cytokine environment regulates a type 2-->0-->1 developmental progression, with IL-12 needed for terminal differentiation and IL-4 delaying this process, rather than a type 1 versus type 2 decision of a type 0 cell...
  59. ncbi Lymphocyte subsets and cytokines in women with gestational diabetes mellitus and their newborn
    A Lapolla
    Metabolic Disorders Section, Department of Medical and Surgical Sciences, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    Cytokine 31:280-7. 2005
    ..and 74 women with normal glucose tolerance (NGT), and their babies, we assessed total lymphocytes, T lymphocyte subsets CD3 and CD8 expressing T cell receptor (TCR) alpha/beta or gamma/delta, CD16 and CD19, pancreatic ..
  60. ncbi A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules
    L Borges
    Immunex Corp, Seattle, WA 98101, USA
    J Immunol 159:5192-6. 1997
    ..Like killer inhibitory receptors, at least two LIRs bind to MHC class I Ags, but their different cellular distribution suggests a distinct role in immune system modulation...
  61. ncbi Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-beta levels after fish oil supplementation of pregnant women
    Susanne Krauss-Etschmann
    Clinical Cooperation Group Pediatric Immune Regulation, Children s Hospital of Ludwig Maximilians University and GSF National Research Center for Environment and Health, Neuherberg, Germany
    J Allergy Clin Immunol 121:464-470.e6. 2008
    ..Because allergies are primed in early infancy and in utero, the fetus might be more accessible to nutritional intervention strategies...
  62. pmc Birth season and environmental influences on blood leucocyte and lymphocyte subpopulations in rural Gambian infants
    Andrew C Collinson
    1Directorate of Child and Women s Health, Bramble Ward, Royal Devon and Exeter Hospital Wonford, Exeter, UK
    BMC Immunol 9:18. 2008
    ....
  63. ncbi T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells
    Michael J Townsend
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
    Immunity 20:477-94. 2004
    ..Our results identify T-bet as a key factor in the terminal maturation and peripheral homeostasis of NK and Valpha14i NKT cells...
  64. ncbi Prognostic impact of tumor infiltrating FOXP3 positive regulatory T cells in diffuse large B-cell lymphoma at diagnosis
    Na Ri Lee
    Division of Hematology Oncology, Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, 561 756, Republic of Korea
    Leuk Lymphoma 49:247-56. 2008
    ..In conclusion, the presence of an increased percentage of FOXP3-positive Tregs in DLBCL is predictive of better prognoses...
  65. ncbi IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger
    Stephane Ferretti
    Novartis Respiratory Research Center, Wimblehurst Road, RH12 5 AB Horsham, UK
    J Immunol 170:2106-12. 2003
    ..In addition, our results suggest that IL-15 could represent a physiological trigger that leads to IL-17 production following bacterial infection...
  66. pmc Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1
    Anthony Meager
    Biotherapeutics, National Institute for Biological Standards and Control, South Mimms, United Kingdom
    PLoS Med 3:e289. 2006
    ....
  67. ncbi Lymphocyte subsets, lymphocyte reactivity to mitogens, NK cell activity and neutrophil and monocyte phagocytic functions in patients with bladder carcinoma
    Zeljko Kastelan
    Urology Department, University Hospital Center, 12 Kispaticeva St, 10 000 Zagreb, Croatia
    Anticancer Res 23:5185-9. 2003
    ..Assessment of immunocompetence in bladder transitional cell carcinoma (TCC) patients...
  68. pmc Changes in leucocyte and lymphocyte subsets during tuberculosis treatment; prominence of CD3dimCD56+ natural killer T cells in fast treatment responders
    H Veenstra
    Division of Molecular Biology and Genetics and MRC Centre for Molecular and Cellular Biology, University of Stellenbosch, PO Box 19063, Tygerberg 7505, South Africa
    Clin Exp Immunol 145:252-60. 2006
    ..This study describes changes in leucocyte and lymphocyte subsets during treatment to find reliable immunological markers for the disease and treatment response...
  69. pmc A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo
    Helena Soares
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 204:1095-106. 2007
    ..The results indicate that two DC subsets have innate propensities to differentially affect the Th1/Th2 balance in vivo and by distinct mechanisms...
  70. ncbi Identification of a B-1 B cell-specified progenitor
    Encarnacion Montecino-Rodriguez
    Department of Pathology and Laboratory Medicine and the Hematopoietic Malignancies Program, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Nat Immunol 7:293-301. 2006
    ..These data indicate that the CD45R(lo-neg)CD19(+) population includes B-1 B cell-specified progenitors and support models proposing distinct developmental pathways for B-1 B cells...
  71. pmc Establishment of reference values of CD4 and CD8 lymphocyte subsets in healthy Nigerian adults
    D K Oladepo
    National Institute for Pharmaceutical Research and Development, Garki, Abuja, Nigeria
    Clin Vaccine Immunol 16:1374-7. 2009
    ..The majority (64%) of the participants had CD4 counts within the range of 501 to 1,000 cells/microl. The reference range for CD4 was 365 to 1,571 cells/microl, while the reference range for CD8 was 145 to 884 cells/microl...
  72. pmc Here today--not gone tomorrow: roles for activating receptors in sustaining NK cells during viral infections
    Seung Hwan Lee
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Eur J Immunol 40:923-32. 2010
    ..Moreover, they demonstrate a previously unappreciated role for activating receptors, i.e. to keep NK cells here today and also tomorrow...
  73. ncbi Tracking changes of lymphocyte subsets and pre-inflammatory mediators in full-term neonates with suspected or documented infection
    E Hotoura
    Neonatal Intensive Care Unit, University Hospital of Ioannina, Ioannina, Leoforos Stavrou Niarchou, Greece
    Scand J Immunol 73:250-5. 2011
    ..made of the cytokines interleukin-6 (IL-6), interleukin-1b (IL-1b) and tumour necrosis factor-α (TNF-α), lymphocyte subsets [CD3+, CD4+, CD8+, natural killer (NK) cells and B cells], the immunoglobulins (Ig) (IgG, IgM and IgA), C-..
  74. ncbi A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells
    K Miyamoto
    Department of Immunology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    Nature 413:531-4. 2001
    ....
  75. ncbi Detrimental immunologic effects of preoperative chemoradiotherapy in advanced rectal cancer
    Matthias W Wichmann
    Department of Surgery, Ludwig Maximilians University, Klinikum Grosshadern, Munich, Germany
    Dis Colon Rectum 46:875-87. 2003
    ..It is not known whether preoperative chemoradiotherapy for advanced rectal cancer influences the perioperative course of immune parameters...
  76. pmc Normal values for CD4 and CD8 lymphocyte subsets in healthy Chinese adults from Shanghai
    Weiming Jiang
    Department of Infectious Diseases, Fudan University Huashan Hospital, Shanghai, China
    Clin Diagn Lab Immunol 11:811-3. 2004
    The aim of this study was to establish reference ranges for lymphocyte subsets in Chinese adults. Venous blood specimens were obtained from 614 healthy, human immunodeficiency virus (HIV)-seronegative adults in Shanghai...
  77. pmc A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules
    Nadine C Fernandez
    Department of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA
    Blood 105:4416-23. 2005
    ..Thus, self-tolerance of NK cells in normal animals can occur independently of MHC-mediated inhibition, and hyporesponsiveness plays a role in self-tolerance of NK cells, as also proposed for B and T cells...
  78. ncbi Developmental program of mouse Valpha14i NKT cells
    Jennifer L Matsuda
    Integrated Department of Immunology, University of Colorado Health Sciences Center, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
    Curr Opin Immunol 17:122-30. 2005
    ..These include several signal transduction molecules, transcription factors and cytokines, including T-bet, members of the NF-kappaB family, Fyn and IL-15...
  79. ncbi Physiological changes of Fas expression in peripheral lymphocyte subsets during the menstrual cycle
    Rie Shinoda
    Department of Clinical Laboratory Science, School of Allied Health Science, Osaka University, 1 7 Yamada oka, Suita, 565 0871 Osaka, Japan
    J Reprod Immunol 60:159-68. 2003
    We have examined changes in peripheral lymphocyte subsets, and Fas expression in these subsets, during the menstrual cycle...
  80. pmc The relationship between lymphocyte subsets and clinico-pathological determinants of survival in patients with primary operable invasive ductal breast cancer
    Z M A Mohammed
    1 Academic Unit of Surgery, College of Medical, Veterinary and Life of Sciences University of Glasgow, Royal Infirmary, Glasgow G31 2ER, UK 2 University Departments of Pathology, College of Medical, Veterinary and Life of Sciences University of Glasgow, Southern General Hospital, Glasgow, UK 3 University Departments of Pathology, Faculty of Veterinary Medicine, Omar Almukhtar University, Al Bayda, Libya
    Br J Cancer 109:1676-84. 2013
    ..The aim of present study was to examine the relationship between tumour lymphocyte subsets infiltrate and standard clinico-pathological factors and survival in patients with primary operable invasive ..
  81. ncbi Immunophenotyping of blood lymphocytes at birth, during childhood, and during adulthood in HIV-1-uninfected Ethiopians
    Aster Tsegaye
    Ethio Netherlands AIDS Research Project, Ethiopian Health and Nutrition Research Institute, PO Box 1242, Addis Ababa, Ethiopia
    Clin Immunol 109:338-46. 2003
    ..b>Lymphocyte subsets (T, B, and NK cells, CD4+ and CD8+ T cells) were determined and T cell activation (CD38 and HLA-DR) and ..
  82. ncbi Elevated circulating CD19+ lymphocytes predict survival advantage in patients with gastric cancer
    Qi Ming Yu
    Zhejiang Cancer Research Institute, Hangzhou, China
    Asian Pac J Cancer Prev 13:2219-24. 2012
    Circulating lymphocyte subsets reflect the immunological status and might therefore be a prognostic indicator in cancer patients...
  83. ncbi Rapid recovery of lymphocyte subsets is not associated with protection from relapse of myelodysplastic syndromes and acute myeloid leukaemia after haematopoietic stem cell transplantation using a reduced intensity conditioning regimen and alemtuzumab
    Katie Matthews
    The Anthony Nolan Research Institute, Royal Free Hospital, London, UK
    Br J Haematol 149:879-89. 2010
    ..Despite the close relationship between the GvL and GvHD immune responses, rapid recovery of lymphocyte subsets was not associated with protection from disease relapse...
  84. ncbi Lymphocyte subsets and expression of differentiation markers in blood and lymphoid organs of rhesus monkeys
    S Sopper
    Institut fur Virologie und Immunbiologie, Universitat Wurzburg, Germany
    Cytometry 29:351-62. 1997
    ..for crossreactivity with macaque cells in order to determine the distribution of functionally important lymphocyte subsets in blood, lymph nodes (LN), and spleen. NK-cells are almost completely absent in LN...
  85. ncbi Reconstitution of maturating and regulatory lymphocyte subsets after cord blood and BMT in children
    E Charrier
    Groupe de Recherche En Transplantation et Immunologie du Sang de Cordon GRETISC, Centre de cancérologie Charles Bruneau, Centre de recherche du CHU Sainte Justine, Montreal, Quebec, Canada
    Bone Marrow Transplant 48:376-82. 2013
    ..These results, therefore, indicate that further research to improve CBT outcome should try to improve thymopoieisis and take advantage of the sustained NK-cell reconstitution...
  86. ncbi Quantification of apoptosis in lymphocyte subsets and effect of apoptosis on apparent expression of membrane antigens
    J Philippe
    Department of Clinical Chemistry, Microbiology, and Immunology, University Hospital of Gent, Belgium
    Cytometry 29:242-9. 1997
    Annexin V binding to phosphatidylserine was evaluated by flow cytometry to examine apoptosis in different lymphocyte subsets of peripheral blood mononuclear cells after a 24 h in vitro culture period...
  87. ncbi Longitudinal peripheral blood lymphocyte subsets correlate with decreased disease activity in juvenile dermatomyositis
    Floranne C Ernste
    Division of Rheumatology, Departments of Medicine and Pediatrics and Health Sciences Research, Mayo Clinic Rochester, Rochester, Minnesota, USA
    J Rheumatol 40:1200-11. 2013
    ..To determine the clinical characteristics and subsets of peripheral blood lymphocytes (PBL), which correlate with decreased disease activity in patients with juvenile dermatomyositis (JDM)...
  88. ncbi Influence of betulinic acid on lymphocyte subsets and humoral immune response in mice
    Y Jine
    College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, PR China
    Pol J Vet Sci 15:305-13. 2012
    ..Thus, betulinic acid is a potential biological response modifier and may strengthen the immune response of its host...
  89. pmc Circulating lymphocyte subsets in different clinical situations after renal transplantation
    Pablo J E J van de Berg
    Department of Experimental Immunology, Academic Medical Centre, Amsterdam, The Netherlands
    Immunology 136:198-207. 2012
    ..To determine the usefulness of lymphocyte subset-typing in clinical practice, large cohort studies are necessary...
  90. ncbi Expression of Th17 and Treg lymphocyte subsets in hypertrophied adenoids of children and its clinical significance
    Kobi Sade
    Allergy and Clinical Immunology Unit, Sourasky Medical Center, Allergy and Immunology, Tel Aviv, Israel
    Immunol Invest 40:657-66. 2011
    ..The purpose of this study is to evaluate the adenoidal lymphocyte subsets to describe the percentage of various lymphocyte subsets in hypertrophied adenoids and correlate them with ..
  91. pmc Engineering lymphocyte subsets: tools, trials and tribulations
    Carl H June
    Department of Pathology and Laboratory Medicine and Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nat Rev Immunol 9:704-16. 2009
    Cell-based therapies with various lymphocyte subsets hold promise for the treatment of several diseases, including cancer and disease resulting from inflammation and infection...
  92. pmc E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas
    G Bain
    Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Mol Cell Biol 17:4782-91. 1997
    ....
  93. ncbi Characterization of autonomic nerve markers and lymphocyte subsets in the ileal Peyer's patch of pigs infected experimentally with Brachyspira hyodysenteriae
    J Kaleczyc
    Department of Animal Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10 719 Olsztyn, Poland
    J Comp Pathol 143:248-57. 2010
    ..Percentages of other lymphocyte subsets (CD2(+), CD4(+), CD5(+), CD8(+), CD5(-)CD8(+)) were comparable between the groups...
  94. pmc Lymphocyte subsets and mood states in panic disorder patients
    Joo Eon Park
    Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    J Korean Med Sci 20:215-9. 2005
    ..b>Lymphocyte subsets counts were made by flow cytometry...
  95. ncbi Age-related changes in lymphocyte subsets of quarter horse foals
    Roger Smith
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station 77843 4467, USA
    Am J Vet Res 63:531-7. 2002
    To characterize changes in lymphocyte subsets over time in foals from birth to 18 weeks of age, accounting for differences among individuals, and to determine the effect of overnight storage of blood samples on foal lymphocyte subset ..
  96. ncbi Different concentrations of interleukins in the peritoneal fluid of women with endometriosis: relationships with lymphocyte subsets
    A Gallinelli
    Department of Gynecologic, Obstetric and Pediatric Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Gynecol Endocrinol 18:144-51. 2004
    ..These data seem to suggest that a reciprocal modulation exists between peritoneal fluid cytokines and T lymphocyte subsets in patients with endometriosis.
  97. ncbi [Changes and analysis of peripheral white blood cells and lymphocyte subsets for patients with pandemic influenza A virus (H1N1) infection]
    Wei Wei Chen
    302 Hospital of PLA, Beijing 100039, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 24:331-3. 2010
    To investigate the characters and changes of peripheral white blood cells and lymphocyte subsets of patients with pandemic influenza A virus (H1N1) infection and to provide evidences for diagnosis, treatment and prognosis of influenza A (..
  98. ncbi Lymphocyte subsets in irradiation-induced sialadenitis of the submandibular gland
    A Teymoortash
    Department of Otolaryngology, Head and Neck Surgery, Philipp University, Marburg, Germany
    Histopathology 47:493-500. 2005
    ..The aim of our study was to determine the phenotype of the inflammatory infiltrate and to study its distribution in the affected submandibular glands...
  99. pmc Early interferon-γ production in human lymphocyte subsets in response to nontyphoidal Salmonella demonstrates inherent capacity in innate cells
    Tonney S Nyirenda
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 5:e13667. 2010
    ..This report identifies the lymphocyte subsets that produce IFNγ early in Salmonella infection.
  100. ncbi Relative contribution of HIV-specific functional lymphocyte subsets restricted by protective and non-protective HLA alleles
    Yoav Peretz
    National Immune Monitoring Laboratory NIML, Genome Quebec, Montreal, Quebec, Canada
    Viral Immunol 24:189-98. 2011
    ..HLA haplotypes influence the relative functional composition of HIV-specific responses...
  101. ncbi NK cells at the interface between innate and adaptive immunity
    A Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Via L B Alberti 2, Italy
    Cell Death Differ 15:226-33. 2008
    ..Indeed, only DCs undergoing this NK-mediated quality control would become fully mature and capable of inducing priming of protective Th1 responses...

Research Grants62

  1. EPICARDIAL ADIPOSE TISSUE, OBESITY AND INFLAMMATION IN ATHEROSCLEROSIS
    Devendra K Agrawal; Fiscal Year: 2013
    ..parameters in epicardial fat will include the changes in adipocyte size, M1/M2 macrophage polarity, T-lymphocyte subsets, levels of pro- and anti-inflammatory mediators and cytokines...
  2. Estrogen and Immunoprotection in Experimental Stroke
    Patricia D Hurn; Fiscal Year: 2013
    ..Invasion by splenic lymphocyte subsets into injured brain also results in two opposing contributions: 1) enhanced local inflammation and macrophage ..
  3. MBSR Symptom Cluster Trial for Breast Cancer Survivors
    Cecile A Lengacher; Fiscal Year: 2013
    ..quality of life, biological stress markers (pro-inflammatory immune cytokines, cellular adhesion molecules, lymphocyte subsets) and stress-related hormones (cortisol, catecholamines)...
  4. Transgenerational exposures as modifiers of host defense against infection
    B Paige Lawrence; Fiscal Year: 2013
    ..AhR ligand, 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) profoundly disrupts the response of specific lymphocyte subsets to infection in the F1 generation, and exciting pilot data reveal that lymphocyte function is affected in F2 ..
  5. HIV-induced immune activation impairs immune reconstitution through S1P
    Christel H Uittenbogaart; Fiscal Year: 2013
    ..2. To determine whether HIV infection affects egress of nave T lymphocyte subsets from the thymus to the periphery through changes in S1P receptor expression...
  6. Regulation of B-Cell Apoptosis by TLR Signaling in Periodontal Disease
    Xiaozhe Han; Fiscal Year: 2012
    ..While various B lymphocyte subsets express multiple TLRs, including TLR4 and TLR9, the role of TLR signaling on B cell apoptosis is entirely ..
  7. Type 1 IFN Function and Signaling in Immunity to Viruses
    CHRISTINE ANNE BIRON; Fiscal Year: 2013
    ..These include effects on lymphocyte subsets. Some are paradoxical, and the mechanisms controlling type 1 IFN effects, to allow access to subset ..
  8. Blocking Hypertension by Regulatory T-lymphocytes
    Douglas F Larson; Fiscal Year: 2013
    ..together, do the classic hypertensive neuroendocrine pathways affect balance and function of these CD4+ lymphocyte subsets? Secondly there are three major cell types in the arterial vasculature;endothelial, smooth muscle, and ..
  9. Impact of Chemotherapy and Stem Cell Transplant on HIV-1 Reservoir Dynamics
    TIMOTHY JENSEN HENRICH; Fiscal Year: 2013
    ..following cytoreductive therapy, but reductions in HIV-1 DNA and subsequent re-expansion of CD4+ lymphocyte subsets and other tissue compartments may lead to changes in the diversity of the remaining viral reservoir...
  10. Quantifying cognitive-motor decline in FIV-infected cats
    Lola C Hudson; Fiscal Year: 2010
    ..Parallel measures of plasma FIV, CSF FIV and lymphocyte subsets will be taken to provide a comprehensive assessment of each aspect of disease progression, to be compared to ..
  11. A Potential State and Relapse Predictive Marker in Schizophrenia
    BRIAN JAMES MILLER; Fiscal Year: 2013
    ..The Career Development Plan will focus on: 1) increasing my knowledge of monocyte and T-helper lymphocyte subsets, 2) developing an understanding of and experience with modern techniques in immunological research, 3) ..
  12. Targeting the mTOR signaling pathway in Autoimmune Lymphoproliferative Syndrome
    David T Teachey; Fiscal Year: 2011
    ..We will investigate the activity of MTIs on lymphocyte subsets, comparing changes in number and function between MTI-treated patients with ALPS versus MTI-treated patients ..
  13. HLA Region and KIR Genomics in Common Variable Immune Deficiency
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2013
    ..analysis has shown a variety of abnormalities in either the number or function of a number of different lymphocyte subsets in both RESPI and CVID patients...
  14. Cell-Stress Induced Immune Responses
    Thomas Spies; Fiscal Year: 2010
    ..In addition, MICA/B function as ligands for an activating receptor, NKG2D, which is broadly expressed on lymphocyte subsets. Engagement of NKG2D can trigger natural killer (NK) cells and augment responses by antigen-specific CD8+ a(..
  15. Immune correlates of steroid responsiveness in ITP
    ELINE TJETSKE LUNING PRAK; Fiscal Year: 2010
    ..determine if dexamethasone yields a different response from prednisone in B and T lymphocyte subsets over time;2...
  16. Chemokines in healing myocardial infarction
    Nikolaos G Frangogiannis; Fiscal Year: 2013
    ..Differential expression of chemokine receptors by monocyte and lymphocyte subsets governs their trafficking in the infarcted myocardium resulting in infiltration with subpopulations that ..
  17. A New Approach to Staphylococcus aureus Vaccine Development - Resubmission 01
    Brad J Spellberg; Fiscal Year: 2013
    ..assessed will be traditional production of opsonophagocytic antibody but also the selective recruitment of lymphocyte subsets and cytokine pathways...
  18. Regulation and Function of Polarity and Asymmetric Cell Division in Immunity
    John T Chang; Fiscal Year: 2013
    ..immunology to test the hypothesis that cell polarity regulates (1) the generation of effector and memory T lymphocyte subsets from their naive predecessors as well as (2) the execution of effector T lymphocyte function...
  19. Regulation of Recall Responses During Ehrlichiosis
    Gary M Winslow; Fiscal Year: 2010
    ..Therefore, in Aim 1 memory lymphocyte subsets and functions critical for protection against high dose IOE challenge will be identified and characterized...
  20. Characterization of Tau Lymphocyte Modulation in Pregnancy
    LEELA E NORONHA; Fiscal Year: 2010
    ..2. To determine the respective contributions of the CD4+ and CD8+ lymphocyte subsets to the defect in cytotoxic T lymphocyte activity...
  21. Michigan Lupus Epidemiology &Surveillance (MILES) Program Longitudinal Cohort
    EMILY CATHERINE SOMERS; Fiscal Year: 2013
    ..The biobank will include serum, plasma, PBMCs, DNA (isolated both from unfractionated PBMCs and lymphocyte subsets), hair and toenail clippings...
  22. Functional Attributes of a CD8+BTLA+ T cell subset in Adoptive T Cell Therapy
    Laszlo G Radvanyi; Fiscal Year: 2013
    ..In parallel, we are performing correlative biomarker studies to identify specific lymphocyte subsets within infused TIL associated with clinical responses...
  23. Innate Immunity Training Program
    Neal Silverman; Fiscal Year: 2013
    ..receptors, NOD-like receptors, and beyond), complement cascades, inflammasome activation, innate-like lymphocyte subsets (B1 B-cells, iNKT cells), protein structure/function, autoimmunity, and vaccine development...
  24. RESOURCE FOR NONHUMAN PRIMATE CELL DEPLETING ANTIBODIES
    Keith A Reimann; Fiscal Year: 2013
    ..Develop "next generation", engineered antibodies for targeting and depleting the major lymphocyte subsets in NHP 2. Engineer antibody Fc regions to modulate effector function 3...
  25. MOLECULAR BASIS OF T CELL HOMING TO INFLAMED SKIN
    Louis Picker; Fiscal Year: 1999
    ..homing is a flexible, yet precisely regulated, process that provide the various tissues of the body with lymphocyte subsets appropriate to their immunologic "needs"...
  26. OPIATE MODULATION OF PULMONARY INFECTION
    Thomas Molitor; Fiscal Year: 2000
    ..bovis activity of T lymphocyte subsets obtained from BCG-immunized swine; and (4) determine the effect of morphine in BCG-immunized swine on ..
  27. MULTIPURPOSE ARTHRITIS & MUSCULOSKELETAL DISEASE CENTER
    HARRY BLUESTEIN; Fiscal Year: 2000
    ..P.I., M. Croft, (L.J.I.A.I.) Will determine the importance of CD4 lymphocyte subsets in the development and progression of an animal model of rheumatoid arthritis. P.I., L...
  28. NEUROIMMUNOMODULATION IN HUMAN GUT MUCOSA
    Peter Anton; Fiscal Year: 1993
    ..b>Lymphocyte subsets with significant numbers of receptors will be rapidly identified by simultaneous fluorescent activated cell (..
  29. THE ROLE OF MYELIN PROTEINS IN EXPERIMENTAL NEURITIS
    Steven Brostoff; Fiscal Year: 1990
    ..We will also investigate the role of lymphocyte subsets in EAN by using monoclonal antibodies that define these subsets...
  30. Chemokine Signaling and Colitis in Gia2 Deficient Mice
    Robert Edwards; Fiscal Year: 2006
    ..T-lymphocyte subsets from wildtype, Gia2 (-/-), and transgenic mice as described above will be studied to identify whether they ..
  31. High-speed cell sorter
    Ronald Veazey; Fiscal Year: 2002
    ..cells, cytokine production, functional capabilities, and antigen-specificities of various well-defined lymphocyte subsets. Furthermore, the capabilities of this equipment also allow for rapid acquisition of immunophenotypic data, ..
  32. Vaccinia virus-specific T-cell phenotypes
    Michael Rock; Fiscal Year: 2005
    ..Using state-of-the-art polychromatic flow cytometry, we can now examine a multitude of lymphocyte subsets in the peripheral blood that previously were inaccessible, each with a unique functional and phenotypic ..
  33. A4B7 INTEGRIN IN INTESTINAL INFLAMMATION AND IMMUNITY
    Eugene Butcher; Fiscal Year: 1999
    ..Specific Aims include: 1) To determine if alpha4Beta7 expression by lymphocyte subsets correlates with and predicts their binding to MAdCAM-1, and their in vivo trafficking to mucosal tissues and ..
  34. GU SITES AND CONSEQUENCES OF HIV INFECTION
    JOHN KRIEGER; Fiscal Year: 1992
    ..and antigen-positivity of the semen, correlating these findings with the presence of culturable virus, T4/T8 lymphocyte subsets, and p24 antigen in the serum, the findings on semen analysts and the presence of pyosemia...
  35. IMMUNE RESPONSE TO BREAST DUCTAL CARCINOMA IN SITU
    Scott Pruitt; Fiscal Year: 1999
    ..Peripheral lymphocyte subsets and xenoreactivity against guinea pig lymphocyte targets will be assessed by flow cytometry throughout these ..
  36. T LYMPHOCYTE-WOUND INTERACTIONS IN TRAUMA
    Adrian Barbul; Fiscal Year: 1991
    ..times post-wounding and determining the subsets present; c) studying the effect of purified wound T lymphocyte subsets harvested at various times post-wounding on in vitro fibroblast activity (replication, chemotaxis, collagen ..
  37. NK CELL ADCC AND CD4+ CELL APOPTOSIS IN HIV+ TISSUES
    Gail Skowron; Fiscal Year: 2003
    ..will be evaluated for the frequency and distribution pattern of NK cells, apoptotic cells, CD4 and CD8 lymphocyte subsets, HIV-1 RNA by in situ hybridization and expression of HIV-1 gp120, gp41 and p24 antigens...
  38. E-SELECTIN LIGANDS ON LYMPHOCYTES
    Mark Jutila; Fiscal Year: 2001
    ..The lymphocyte subsets that have the capacity to bind E-selectin represent cells that have undergone conversion to a "memory" ..
  39. IMMUNE-MEDIATED BILE DUCT INJURY IN BILIARY ATRESIA
    SHERI KRAMS; Fiscal Year: 2001
    ..We have obtained preliminary data to explain the localization of specific lymphocyte subsets to biliary atresia liver. Furthermore, we have identified candidate mediators of cholangiocyte cell death...
  40. Impact of Fli-1 expression on lupus disease development
    Xian Zhang; Fiscal Year: 2007
    ..effect of Fli-1 in murine lupus appears to be mediated through multiple factors including alterations in lymphocyte subsets and cytokine/chemokine production...
  41. IMMUNE RESPONSE IN THE LUNG TO TB PROTEINS IN AIDS
    William Rom; Fiscal Year: 2002
    ..status and study their BAL cells and peripheral blood mononuclear cells (PBMCs) by immunophenotyping of lymphocyte subsets and by proliferation, IFN-gamma release, and CTL assays to assess their in vitro response to STCF and PPD...
  42. NOVEL THERAPEUTIC APPROACHES IN HIV-ASSOCIATED LYMPHOMAS
    Thomas Kipps; Fiscal Year: 1993
    ..history, HIV risk behaviors, prior HIV complications, prior treatment with anti-retroviral and other drugs, lymphocyte subsets, p24 antigen in addition to staging...
  43. Alcoholism: Modulation & Function of Lymphocyte Subsets
    Robert Cook; Fiscal Year: 2005
    ....
  44. NATURE AND FUNCTION OF T LYMPHOCYTE CHEMOTACTIC FACTOR
    Dennis Van Epps; Fiscal Year: 1990
    ..using specific fluorescent probes and quantitative flow cytometry and will allow us to determine which lymphocyte subsets respond to LCF...
  45. T LYMPHOCYTE SUBSETS AND HOST DEFENSE AGAINST P CARINII
    JUDD SHELLITO; Fiscal Year: 2001
    ..carinii infection are unknown. This application proposes to investigate the role of T lymphocyte subsets (Th1/Th2) in host responses to this infection. Preliminary data show that clearance of P...
  46. MEMBRANE LIPID MATRIX, CYTOSKELETON AND IMMUNE FUNCTION
    Elizabeth Repasky; Fiscal Year: 1990
    ..amount of the cytoskeletal protein spectrin associated with the inner surface of the plasma membrane among lymphocyte subsets in vivo and in vitro...
  47. T-Lymphocyte role in Lung Ischemia-Reperfusion Injury
    Mary Townsley; Fiscal Year: 2004
    ..We will measure circulating lymphocyte numbers and differentiate lymphocyte subsets using flow cytometry in isolated rat and mouse lungs that are subjected to defined periods of I/R...
  48. THE IMMUNOLOGY OF ALCOHOLIC LIVER DISEASE
    Antonio Chedid; Fiscal Year: 1991
    ..The specific aims of this research proposal are:1) to determine in alcoholic liver injury the lymphocyte subsets that participate in the immune response of the hepatocytes, and 2) to test for the presence of the ..
  49. CCR9 AND TECK IN INTESTINAL LYMPHOCYTE TRAFFICKING
    Eugene Butcher; Fiscal Year: 2000
    ..Flow cytometric and cytokine assays will characterize the phenotype and functional significance of CCR9+ lymphocyte subsets in man, and transwell assays of lymphocyte subset chemotaxis will be used to ask if CCR9 and TECK play a ..
  50. COSTIMULATION IN PERIPHERAL T CELL TOLERANCE AND ANERGY
    Jeffrey Bluestone; Fiscal Year: 2000
    ..between receptor-mediated signal transduction pathways that regulate the functions of different T lymphocyte subsets. The Pis will further characterize the signaling block in anergic T cells to produce IL-2...
  51. TRIAL AND CORRELATIVE STUDIES OF DDI IN AIDS-LYMPHOMA
    John Byrnes; Fiscal Year: 1993
    ..3) Correlation studies of immune composition lymphocyte subsets determined by two and three color fluorescence, T cell function and natural killer cell activity determined ..
  52. IMMUNOSUPPRESSIVE PROPERTIES OF 1,25-DIHYDROXYVITAMIN D3
    Jacques Lemire; Fiscal Year: 1993
    ..Further studies examining lymphocyte subsets revealed the T helper cell (TH) to be the specific cellular target for the immunoinhibitory effect of 1,25- (..
  53. INTRACELLULAR CALCIUM REGULATION IN ALZHEIMER'S DISEASE
    ANGELIKA GROSSMAN; Fiscal Year: 1991
    ..grant is to determine whether transmembrane signaling and intracellular calcium regulation is impaired in T-lymphocyte subsets fr m Alzheimer's disease (AD) patients...
  54. REGULATION OF GRANULOMA IN TUBERCULOSIS
    Padmini Salgame; Fiscal Year: 2001
    ..granulomatous reaction by immunocytochemical and electron microscopic studies; ii) to evaluate the role of T-lymphocyte subsets in the regulation of the granulomatous reaction by T-cell cloning, examination of the differentiation of ..
  55. EVOLUTION OF AN ACUTELY LETHAL SIV
    PATRICIA FULTZ; Fiscal Year: 1999
    ..From initial infection to late-stage HIV disease multiple signs of activation involving all lymphocyte subsets have been documented...
  56. Origins of specialized Mucosal Lymphocyte Subsets and Immunoglobulin Isotypes
    MICHAEL CRISCITIELLO; Fiscal Year: 2009
    ..of gut associated lymphoid tissues (GALT) in mouse and man have provided much insight into the specialized lymphocyte subsets and immunoglobulin (Ig) isotypes that manage the balance between tolerance to food antigens and commensals ..
  57. GONADOTROPIN-RELEASING HORMONE AND AUTOIMMUNITY
    Jill Jacobson; Fiscal Year: 2000
    ..Little is known about which lymphocyte subsets produce and respond to GnRH...
  58. CCR4 IN SKIN LYMPHOCYTE HOMING AND IMMUNITY
    James Campbell; Fiscal Year: 2000
    ..differentially expressed in various tissue types, suggesting a role in the differential homing of specific lymphocyte subsets to various types of tissue...
  59. IMMUNOLOGIC STUDY OF THE EYE
    Henry Kaplan; Fiscal Year: 1993
    ..Our recent studies have employed the hapten trinitrophenol (TNP) coupled to splenocytes or specific lymphocyte subsets to induce TNP-ACAID...
  60. IMMUNE FUNCTIONS OF THE LUNG
    H Kaltreider; Fiscal Year: 1990
    ..Project 2 will test the hypothesis that the composition and states of activation of lymphocyte subsets that traffic into lungs modulate pulmonary immune responses...
  61. INTRACELLULAR CYTOKINES AND LABORATORY INDUCED STRESS
    Kevin Maher; Fiscal Year: 2000
    ..with the following aims: 1) To determine whether baseline intracellular cytokine production profiles of lymphocyte subsets (T helper, T cytotoxic, B, and NK cells) differ between HIV seronegative and HIV infected individuals; 2)To ..
  62. STRUCTURE AND DIVERSITY IN THE IMMUNE SYSTEM
    Lisa Steiner; Fiscal Year: 2004
    ..cells and organs of the immune system, for example, the nature of the progenitor cells from which different lymphocyte subsets are derived, and the interactions between lymphocytes and the thymic epithelium required for the maturation ..