lymphocytes

Summary

Summary: White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each); those with characteristics of neither major class are called null cells.

Top Publications

  1. pmc c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells
    Zuqin Nie
    Laboratory of Pathology, NCI, Bethesda, MD 20892, USA
    Cell 151:68-79. 2012
  2. pmc Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes
    Changchun Xiao
    Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 9:405-14. 2008
  3. doi The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling
    Hergen Spits
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Centre, Amsterdam, The Netherlands
    Nat Immunol 12:21-7. 2011
  4. ncbi IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity
    V Shankaran
    Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 410:1107-11. 2001
  5. pmc The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells
    Thomas Hoyler
    IMMH, Institute of Medical Microbiology and Hygiene, University of Freiburg, Germany
    Immunity 37:634-48. 2012
  6. doi Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    Kazuyo Moro
    Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Nature 463:540-4. 2010
  7. pmc Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity
    David G DeNardo
    Department of Pathology, University of California, 513 Parnassus Ave, HSW 450C, San Francisco, CA 94143, USA
    Cancer Metastasis Rev 29:309-16. 2010
  8. ncbi Innate immune recognition
    Charles A Janeway
    Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Annu Rev Immunol 20:197-216. 2002
  9. pmc Neutrophil/lymphocyte ratio predicts chemotherapy outcomes in patients with advanced colorectal cancer
    W Chua
    Sydney Cancer Centre, Concord Repatriation General Hospital, Hospital Road, Concord, New South Wales 2139, Australia
    Br J Cancer 104:1288-95. 2011
  10. doi Elevated preoperative neutrophil to lymphocyte ratio predicts poor survival following resection in late stage gastric cancer
    Mi Ran Jung
    Division of Gastroenterologic Surgery, Department of Surgery, Chonnam National University Medical School, Gwangju, Korea
    J Surg Oncol 104:504-10. 2011

Detail Information

Publications471 found, 100 shown here

  1. pmc c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells
    Zuqin Nie
    Laboratory of Pathology, NCI, Bethesda, MD 20892, USA
    Cell 151:68-79. 2012
    ..This rule of Myc action explains the vast majority of Myc biology observed in literature...
  2. pmc Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes
    Changchun Xiao
    Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 9:405-14. 2008
    ..Here we generated mice with higher expression of miR-17-92 in lymphocytes. These mice developed lymphoproliferative disease and autoimmunity and died prematurely...
  3. doi The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling
    Hergen Spits
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Centre, Amsterdam, The Netherlands
    Nat Immunol 12:21-7. 2011
    ..Analogous to helper T cell subsets, these evolutionarily conserved yet distinct ILCs seem to have important roles in protective immunity, and their dysregulation can promote immune pathology...
  4. ncbi IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity
    V Shankaran
    Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 410:1107-11. 2001
    b>Lymphocytes were originally thought to form the basis of a 'cancer immunosurveillance' process that protects immunocompetent hosts against primary tumour development, but this idea was largely abandoned when no differences in primary ..
  5. pmc The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells
    Thomas Hoyler
    IMMH, Institute of Medical Microbiology and Hygiene, University of Freiburg, Germany
    Immunity 37:634-48. 2012
    ..Thus, our data demonstrate that GATA-3 is essential for ILC2 fate decisions and reveal similarities between the transcriptional programs controlling ILC and T helper cell fates...
  6. doi Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    Kazuyo Moro
    Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Nature 463:540-4. 2010
    ..Natural killer (NK) cells are innate lymphocytes that, unlike T and B lymphocytes, do not express antigen receptors but rapidly exhibit cytotoxic activities ..
  7. pmc Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity
    David G DeNardo
    Department of Pathology, University of California, 513 Parnassus Ave, HSW 450C, San Francisco, CA 94143, USA
    Cancer Metastasis Rev 29:309-16. 2010
    ..of myeloid cells to promote or repress cancerous growths, polarized adaptive immune responses by B and T lymphocytes have been identified as regulators of many aspects of myeloid cell biology by specifically regulating their ..
  8. ncbi Innate immune recognition
    Charles A Janeway
    Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Annu Rev Immunol 20:197-216. 2002
    ..Thus, microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens...
  9. pmc Neutrophil/lymphocyte ratio predicts chemotherapy outcomes in patients with advanced colorectal cancer
    W Chua
    Sydney Cancer Centre, Concord Repatriation General Hospital, Hospital Road, Concord, New South Wales 2139, Australia
    Br J Cancer 104:1288-95. 2011
    ..The use of inflammatory markers based on differential white-cell counts, such as the neutrophil/lymphocyte ratio (NLR), may be simple and readily available biomarkers...
  10. doi Elevated preoperative neutrophil to lymphocyte ratio predicts poor survival following resection in late stage gastric cancer
    Mi Ran Jung
    Division of Gastroenterologic Surgery, Department of Surgery, Chonnam National University Medical School, Gwangju, Korea
    J Surg Oncol 104:504-10. 2011
    ..Elevated neutrophil to lymphocyte ratio (N/L ratio) has been shown to be a prognostic indicator in various cancers. We aimed to investigate the prognostic significance of the preoperative N/L ratio in late stage gastric cancer...
  11. doi Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161
    Jenny M Mjösberg
    Tytgat Institute for Liver and Intestinal Research, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 12:1055-62. 2011
    ..There was enrichment for CRTH2(+) ILCs in nasal polyps of chronic rhinosinusitis, a typical type 2 inflammatory disease. Our data identify a unique type of human ILC that provides an innate source of T helper type 2 (T(H)2) cytokines...
  12. ncbi Damage formation and repair efficiency in the p53 gene of cell lines and blood lymphocytes assayed by multiplex long quantitative polymerase chain reaction
    Yu Chieh Wang
    Department of Biology, National Taiwan Normal University, Taipei, Taiwan, ROC
    Anal Biochem 319:206-15. 2003
    ..damage formation and repair efficiency in the p53 tumor suppressor gene of various cultured cell lines and lymphocytes using a nonradioactive multiplex long quantitative polymerase chain reaction (QPCR) assay, which amplified a 7-..
  13. doi The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells
    Jenny Mjösberg
    Tytgat Institute for Liver and Intestinal Research, University of Amsterdam, The Netherlands
    Immunity 37:649-59. 2012
    ..Hence, we identify GATA3, potently regulated by TSLP, as an essential transcription factor for the function of human ILC2s...
  14. pmc Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
    J J Peschon
    Immunex Research and Development Corporation, Seattle, Washington 98101
    J Exp Med 180:1955-60. 1994
    ..Significantly, these studies indicate that the phase of thymocyte expansion occurring before the onset of T cell receptor gene rearrangement is critically dependent upon, and mediated by the high affinity receptor for IL-7...
  15. pmc Functional complementation between FADD and RIP1 in embryos and lymphocytes
    Haibing Zhang
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nature 471:373-6. 2011
    ..Conversely, the developmental defect of Rip1(-/-) lymphocytes was partially corrected by FADD deletion...
  16. pmc Molecular basis of calcium signaling in lymphocytes: STIM and ORAI
    Patrick G Hogan
    Department of Pathology, Harvard Medical School, Immune Disease Institute, Children s Hospital Boston, Massachusetts 02115, USA
    Annu Rev Immunol 28:491-533. 2010
    ..In this review, we discuss selected aspects of Ca(2+) signaling in cells of the immune system, focusing on the roles of STIM and ORAI proteins in store-operated Ca(2+) entry...
  17. pmc Analysis of miRNA and mRNA expression profiles highlights alterations in ionizing radiation response of human lymphocytes under modeled microgravity
    Cristina Girardi
    Dipartimento di Biologia, Universita degli Studi di Padova, Padova, Italy
    PLoS ONE 7:e31293. 2012
    ....
  18. doi Intraepithelial lymphocytes in celiac disease immunopathology
    Valérie Abadie
    Sainte Justine Hospital Research Centre, Department of Microbiology and Immunology, Faculty of Medicine, University of Montreal, Montreal, QC, H3T 1C5, Canada
    Semin Immunopathol 34:551-66. 2012
    ..antibodies, and autoantibodies against tissue transglutaminase 2 and the activation of intraepithelial lymphocytes (IELs) leading to the destruction of the intestinal epithelium...
  19. doi Temporal and spatial dynamics of cerebral immune cell accumulation in stroke
    Mathias Gelderblom
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Stroke 40:1849-57. 2009
    ..The objectives of this study were to define the temporal and spatial infiltration of immune cell populations and their activation patterns in a murine cerebral ischemia-reperfusion injury model...
  20. ncbi Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes
    L Osborn
    Biogen, Inc, Cambridge Center, Massachusetts 02142
    Cell 59:1203-11. 1989
    ..undescribed adhesion molecule, VCAM-1, which is induced by cytokines on human endothelial cells and binds lymphocytes. Using a novel method requiring neither monoclonal antibodies nor purified protein, VCAM-1-expressing clones ..
  21. pmc Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease
    Alevtina Gall
    Department of Immunology, University of Washington School of Medicine, Seattle, 98195, USA
    Immunity 36:120-31. 2012
    ..These findings reveal a stepwise progression of autoimmune disease in Trex1-deficient mice, with implications for the treatment of AGS and related disorders...
  22. ncbi Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection
    Olivier Hermine
    Department of Hematology and Centre National de la Recherche Scientifique Unité Mixte de Recherche 8603, Hopital Necker, Paris, France
    N Engl J Med 347:89-94. 2002
    ..We undertook this study after a patient with splenic lymphoma with villous lymphocytes had a hematologic response after antiviral treatment of HCV infection.
  23. pmc Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria
    Gregory F Sonnenberg
    Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 336:1321-5. 2012
    ..Collectively, these data indicate that ILCs regulate selective containment of lymphoid-resident bacteria to prevent systemic inflammation associated with chronic diseases...
  24. ncbi Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3
    Bingzhen Lin
    The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 116:527-40. 2004
    ....
  25. pmc Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma
    Jinliang Xing
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Natl Cancer Inst 100:1104-12. 2008
    ..Renal cell carcinoma accounts for 85% of all renal cancers. No studies have investigated the association between mtDNA content and the risk of renal cell carcinoma...
  26. doi Blood neutrophil-to-lymphocyte ratio predicts survival in patients with colorectal liver metastases treated with systemic chemotherapy
    Yoji Kishi
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Ann Surg Oncol 16:614-22. 2009
    ..Whether neutrophil-to-lymphocyte ratio (NLR) predicts survival of patients with colorectal liver metastases (CLM) treated with systemic chemotherapy remains unclear...
  27. doi Elevated neutrophil to lymphocyte ratio predicts survival in advanced pancreatic cancer
    Xin An
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, P R China
    Biomarkers 15:516-22. 2010
    ..Elevated neutrophil to lymphocyte ratio (NLR) is linked with worse survival in many malignancies, whereas its association with pancreatic cancer (PC) remains unclear...
  28. pmc Lymphocytes and the adventitial immune response in atherosclerosis
    Kirsti A Campbell
    Cardiovascular Research Center, University of Virginia, Charlottesville, USA
    Circ Res 110:889-900. 2012
    ..In this review of the contributions of the adventitia and adventitial lymphocytes to the development of atherosclerosis, we discuss recent research on the formation and structural nature of ..
  29. pmc Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes
    Jessica Wahlgren
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Box 480 and Department of Chemistry and Molecular Biology, Lundberg Laboratory, University of Gothenburg, Box 462, 405 30 Gothenburg, Sweden
    Nucleic Acids Res 40:e130. 2012
    ..The vesicles effectively delivered the administered siRNA into monocytes and lymphocytes, causing selective gene silencing of mitogen-activated protein kinase 1...
  30. doi Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues
    Jochem H Bernink
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 14:221-9. 2013
    ..The frequency of the ILC1 subset was much higher in inflamed intestine of people with Crohn's disease, which indicated a role for these IFN-γ-producing ILC1 cells in the pathogenesis of gut mucosal inflammation...
  31. doi Possible metabolic pathways of ethanol responsible for oxidative DNA damage in human peripheral lymphocytes
    Yu Yan
    Department of Pharmacology, Shenyang Pharmaceutical University, China
    Alcohol Clin Exp Res 35:1-9. 2011
    ..However, there have been few studies on the genotoxicity induced by ethanol in human peripheral lymphocytes under binge drinking conditions...
  32. pmc Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice
    Dhanalakshmi Chinnasamy
    Surgery Branch, National Cancer Institute, Clinical Research Center, Bethesda, Maryland 20892, USA
    J Clin Invest 120:3953-68. 2010
    ..T cells transduced with VEGFR-2 CAR showed durable and increased tumor infiltration, correlating with their antitumor effect. This approach provides a potential method for the gene therapy of a variety of human cancers...
  33. ncbi Inflammation in neurodegenerative disease--a double-edged sword
    Tony Wyss-Coray
    Gladstone Institute of Neurological Disease and Department of Neurology, University of California San Francisco, San Francisco, CA 94141, USA
    Neuron 35:419-32. 2002
    ..Since many inflammatory responses are beneficial, directing and instructing the inflammatory machinery may be a better therapeutic objective than suppressing it...
  34. ncbi Chemokines: a new classification system and their role in immunity
    A Zlotnik
    DNAX Research Institute, Palo Alto, California 94304, USA
    Immunity 12:121-7. 2000
  35. ncbi Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer
    S R Walsh
    Department of Colorectal Surgery, West Suffolk Hospital NHS Trust, UK
    J Surg Oncol 91:181-4. 2005
    ..Simple methods to identify colorectal cancer patients at risk of recurrence are needed. This study aimed to determine if neutrophil-to-lymphocyte ratio (NLR) predicts survival in colorectal cancer patients...
  36. ncbi Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
    Rajita Pappu
    Cardiovascular Research Institute, University of California, San Francisco, 600 16th Street S472D, San Francisco, CA 94143 2240, USA
    Science 316:295-8. 2007
    b>Lymphocytes require sphingosine-1-phosphate (S1P) receptor-1 to exit lymphoid organs, but the source(s) of extracellular S1P and whether S1P directly promotes egress are unknown...
  37. ncbi Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    Mehrdad Matloubian
    Howard Hughes Medical Institute and Department of Microbiology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0414, USA
    Nature 427:355-60. 2004
    ..We find that FTY720 treatment downregulates S1P1, creating a temporary pharmacological S1P1-null state in lymphocytes, providing an explanation for the mechanism of FTY720-induced lymphocyte sequestration...
  38. doi Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation
    Ying Li
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Cell 147:629-40. 2011
    ..Specialized intraepithelial lymphocytes (IELs), which reside at these sites, are important as a first line of defense as well as in epithelial barrier ..
  39. doi Innate lymphoid cells: emerging insights in development, lineage relationships, and function
    Hergen Spits
    Tytgat Institute of Liver and Intestinal Research of the Academic Medical Center, Amsterdam 1105 AZ, The Netherlands
    Annu Rev Immunol 30:647-75. 2012
    ..We also discuss the potential roles of ILCs in the pathology of immune-mediated inflammatory and infectious diseases including allergy...
  40. ncbi Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders
    K Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, Saitama, Japan
    Mol Psychiatry 9:406-16. 2004
    ..In addition, we found the altered expression of LIM and HSPF1 both in the brains and lymphoblastoid cells in bipolar disorder. These genes may have pathophysiological importance and would be novel candidate genes for bipolar disorder...
  41. ncbi Evaluating the comparability of gene expression in blood and brain
    Patrick F Sullivan
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7264, USA
    Am J Med Genet B Neuropsychiatr Genet 141:261-8. 2006
    ..This suggests that the cautious and thoughtful use of peripheral gene expression may be a useful surrogate for gene expression in the CNS when it has been determined that the relevant gene is expressed in both...
  42. pmc IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease
    Alessandra Geremia
    Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 9DU, England, UK
    J Exp Med 208:1127-33. 2011
    ..ILCs may contribute to intestinal inflammation through cytokine production, lymphocyte recruitment, and organization of the inflammatory tissue and may represent a novel tissue-specific target for subtypes of IBD...
  43. pmc Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice
    Koubun Yasuda
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663 8501, Japan
    Proc Natl Acad Sci U S A 109:3451-6. 2012
    ..Finally, IL-33-stimulated NH cells induce lung eosinophilic inflammation and might aid to expel infected worms in the lungs...
  44. pmc Interferon-lambda (IFN-λ) induces signal transduction and gene expression in human hepatocytes, but not in lymphocytes or monocytes
    Harold Dickensheets
    Division of Therapeutic Proteins, Center for Drug Evaluation and Research, U S Food and Drug Administration, 29 Lincoln Dr, Bethesda, MD 20892, USA
    J Leukoc Biol 93:377-85. 2013
    ..However, unlike IFN-α, IFN-λ did not induce STAT activation or ISG expression by purified lymphocytes or monocytes...
  45. ncbi Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1
    C Berlin
    Department of Pathology, Stanford University, California 94305
    Cell 74:185-95. 1993
    The mucosal vascular addressin, MAdCAM-1, is an immunoglobulin superfamily adhesion molecule for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte traffic into Peyer's patches (PP) and the intestinal lamina ..
  46. doi Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction
    Julio Nunez
    Servicio de Cardiologia, Hospital Clinico Universitario, Universitat de Valencia, Valencia, Spain
    Am J Cardiol 101:747-52. 2008
    ..In conclusion, N/L max is a useful marker to predict subsequent mortality in patients admitted for STEMI, with a superior discriminative ability than total WBC max...
  47. doi Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity
    Carine Duffaut
    Equipe AVENIR Institut National de la Santé et de la Recherche Médicale INSERM, U858, Hôpital Rangueil Bat L4, Toulouse, France
    Biochem Biophys Res Commun 384:482-5. 2009
    ..Lack of lymphocytes in the RAG2(-/-) mice did not affect the onset of obesity and the state of insulin resistance...
  48. doi The antioxidant effects of vitamin A, C, and E on aflatoxin B1-induced oxidative stress in human lymphocytes
    L Alpsoy
    Fatih University, Faculty of Art and Science, Department of Biology, Istanbul, Turkey
    Toxicol Ind Health 25:121-7. 2009
    ..study was to investigate the possible protective role of vitamin A, C, and E on aflatoxin B(1)-induced in human lymphocytes using biochemical approaches...
  49. doi Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma
    Karim J Halazun
    Department of Organ Transplantation, New York Presbyterian Hospital, Columbia University, MHB 7GS 313, 177 Ft Washington Avenue, New York, NY 10032, USA
    Ann Surg 250:141-51. 2009
    ..We aimed to determine whether NLR predicts outcome in patients undergoing OLT for HCC...
  50. doi High blood neutrophil-to-lymphocyte ratio is an indicator of poor prognosis in malignant mesothelioma patients undergoing systemic therapy
    Steven C H Kao
    Department of Medical Oncology, Sydney Cancer Centre, Australia
    Clin Cancer Res 16:5805-13. 2010
    ..We have investigated blood neutrophil-to-lymphocyte ratio (NLR), an index of systemic inflammation, as a prognostic factor in MM patients...
  51. pmc The association of pre-treatment neutrophil to lymphocyte ratio with response rate, progression free survival and overall survival of patients treated with sunitinib for metastatic renal cell carcinoma
    Daniel Keizman
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Eur J Cancer 48:202-8. 2012
    ..Sunitinib is a standard treatment for metastatic renal cell carcinoma (mRCC). The neutrophil to lymphocyte ratio (NLR), an index of systemic inflammation, is associated with outcome in several cancer types...
  52. doi Lymphocytes in obesity-related adipose tissue inflammation
    A Chatzigeorgiou
    Department of Internal Medicine III, Division of Vascular Inflammation, Diabetes and Kidney, University Clinic Carl Gustav Carus, University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Diabetologia 55:2583-92. 2012
    ..In contrast, less is known about the role of lymphocytes. Recent studies have implicated different lymphocyte subsets in WAT inflammation...
  53. ncbi Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance
    Antonio Carrillo-Vico
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine, Avda Sanchez Pizjuan 4, 41009 Seville, Spain
    FASEB J 18:537-9. 2004
    ..Here, for the first time, we document that both resting and phytohemagglutinin-stimulated human lymphocytes synthesize and release large amounts of melatonin, with the melatonin concentration in the medium increasing up ..
  54. pmc Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival
    Nancie J Maciver
    Duke University Medical College, Durham, NC 27710, USA
    J Leukoc Biol 84:949-57. 2008
    b>Lymphocytes require glucose uptake and metabolism for normal survival and function...
  55. doi CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis
    Lucy A Truman
    Medical Research Council MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    Blood 112:5026-36. 2008
    ..that CX3CL1/fractalkine, a chemokine and intercellular adhesion molecule, is released rapidly from apoptotic lymphocytes, via caspase- and Bcl-2-regulated mechanisms, to attract macrophages...
  56. pmc Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines
    Stephan Hailfinger
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 108:14596-601. 2011
    ..These findings identify a central role for Malt1-dependent RelB cleavage in canonical NF-κB activation and thereby provide a rationale for the targeting of Malt1 in immunomodulation and cancer treatment...
  57. pmc Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques
    Rik L De Swart
    Department of Virology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    PLoS Pathog 3:e178. 2007
    ..B- and T-lymphocytes expressing CD150 were the major target cells for MV infection...
  58. ncbi Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator
    C F Eisenbeis
    Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637, USA
    Genes Dev 9:1377-87. 1995
    ..The amino-terminal DNA-binding domain of Pip exhibits a high degree of homology to the DNA-binding domains of members of the interferon regulatory factor (IRF) family, which includes IRF-1, IRF-2, ICSBP, and ISGF3 gamma...
  59. pmc Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells
    Carsten Krieg
    Division of Immunology and Allergy, University Hospital of Lausanne, CH 1011 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 107:11906-11. 2010
    ..Thus, IL-2/anti-IL-2 antibody complexes might improve current strategies of IL-2-based tumor immunotherapy...
  60. pmc A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma
    Kimberly Noonan
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans Street, Baltimore, MD 21231, USA
    Blood 116:3554-63. 2010
    ..Here we demonstrate the critical role of interleukin-17-producing marrow infiltrating lymphocytes (MILs) in OC activation and development of bone lesions in myeloma patients...
  61. doi Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes
    Su Jin Kang
    School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, Korea
    Environ Mol Mutagen 49:399-405. 2008
    ..In this study, we investigated the underlying mechanism of nano-TiO2-induced cytotoxicity in peripheral blood lymphocytes. We examined the genotoxic effects of nano-TiO2 in lymphocytes using alkaline single-cell gel electrophoresis (..
  62. ncbi Leishmania donovani: identification of stimulatory soluble antigenic proteins using cured human and hamster lymphocytes for their prophylactic potential against visceral leishmaniasis
    Ravendra Garg
    Division of Parasitology, Central Drug Research Institute, Lucknow, India
    Vaccine 24:2900-9. 2006
    ..mononuclear cells (PBMCs) from cured visceral leishmaniasis (VL) patients, endemic and non-endemic controls and lymphocytes/peritoneal macrophages of cured hamsters...
  63. pmc ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replication
    Guerline Clerzius
    Virus Cell Interactions Laboratory, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
    J Virol 83:10119-28. 2009
    ..This activation is transient during the human immunodeficiency virus type 1 (HIV-1) infection of lymphocytes, and the protein is not activated at the peak of infection...
  64. pmc The oncogenic BRAF kinase inhibitor PLX4032/RG7204 does not affect the viability or function of human lymphocytes across a wide range of concentrations
    Begona Comin-Anduix
    Department of Surgery, Division of Surgical Oncology, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California 90095 1782, USA
    Clin Cancer Res 16:6040-8. 2010
    ..Combining PLX4032 with immunotherapy may allow expanding the durability of responses. The effects of PLX4032 on immune cells were studied to explore the feasibility of future combinatorial approaches with immunotherapy for melanoma...
  65. ncbi Microgel electrophoresis: sensitivity, mechanisms, and DNA electrostretching
    N P Singh
    Bioelectromagnetics Research Laboratory, University of Washington, Seattle 98195 7962, USA
    Mutat Res 383:167-75. 1997
    ..We capitalize on this behavior by developing a neutral microgel method to stretch chromosomes...
  66. pmc HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytes
    Cinzia Nobile
    Virus and Immunity Unit, Department of Virology, Institut Pasteur, URA CNRS 3015, 28 rue du Dr Roux, Paris Cedex 15, France
    J Virol 84:2282-93. 2010
    ..We further characterized the morphology, cytoskeleton dynamics, and motility of HIV-1-infected lymphocytes. By using scanning electron microscopy, confocal immunofluorescence microscopy, and ImageStream technology, ..
  67. pmc Prevention of lymphocyte cell death in sepsis improves survival in mice
    R S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 96:14541-6. 1999
    ..of blocking lymphocyte apoptosis provide compelling evidence that immunodepression resulting from the loss of lymphocytes is a central pathogenic event in sepsis, and they challenge the current paradigm that regards sepsis as a ..
  68. ncbi Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte
    R S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nat Immunol 1:496-501. 2000
    ..Thus, caspase inhibitors enhance immunity by preventing lymphocyte apoptosis and lymphocytes act rapidly, within 24 h, to control infection.
  69. ncbi An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans
    Stefano Bonassi
    Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy
    Carcinogenesis 28:625-31. 2007
    The frequency of micronuclei (MN) in peripheral blood lymphocytes (PBL) is extensively used as a biomarker of chromosomal damage and genome stability in human populations...
  70. doi Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies
    Stefano Bonassi
    Unit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, 00166 Rome, Italy
    Mutagenesis 26:93-100. 2011
    ..53; 95% CI: 1.04-2.25). This study provided preliminary evidence that MN frequency in peripheral blood lymphocytes is predictive of cancer risk, suggesting that increased MN formation is associated with early events in ..
  71. pmc Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction
    Miriam Erlacher
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    J Exp Med 203:2939-51. 2006
    ..The loss of Bim protects lymphocytes from apoptosis induced by cytokine deprivation and deregulated Ca++ flux and interferes with the deletion of ..
  72. pmc A model of immune regulation as a consequence of randomized lymphocyte division and death times
    E D Hawkins
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 104:5032-7. 2007
    ..How lymphocytes integrate receptor-mediated signals influencing these cell fates is a fundamental question for understanding ..
  73. doi Adipose tissue inflammation: novel insight into the role of macrophages and lymphocytes
    Henrike Sell
    Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Dusseldorf, Germany
    Curr Opin Clin Nutr Metab Care 13:366-70. 2010
    ..This review presents an update on human and rodent studies analyzing the nature of fat-infiltrating immune cells, the time course of adipose tissue infiltration and underlying mechanisms...
  74. pmc Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals
    Jun Ding
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, 48109, USA
    Am J Hum Genet 87:779-89. 2010
    ....
  75. doi DNA double-strand break repair of blood lymphocytes and normal tissues analysed in a preclinical mouse model: implications for radiosensitivity testing
    Claudia E Rübe
    Department of Radiation Oncology, Saarland University, Homburg Saar, Germany
    Clin Cancer Res 14:6546-55. 2008
    ..Using a preclinical mouse model, the highly sensitive gammaH2AX-foci approach was tested to verify even subtle, genetically determined DSB repair deficiencies known to be associated with increased normal tissue radiosensitivity...
  76. ncbi The immune modulator FTY720 targets sphingosine 1-phosphate receptors
    Volker Brinkmann
    Department of Transplantation, Novartis Pharma AG, Lichtstrasse 35, CH 4002 Basel, Switzerland
    J Biol Chem 277:21453-7. 2002
    ..FTY720 elicits a lymphopenia resulting from a reversible redistribution of lymphocytes from circulation to secondary lymphoid tissues by unknown mechanisms...
  77. pmc Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice
    C Berlin-Rufenach
    Leukocyte Adhesion Laboratory, Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom
    J Exp Med 189:1467-78. 1999
    ..antigen (LFA)-1(-/-) mice, we have examined the role of LFA-1 and other integrins in the recirculation of lymphocytes. LFA-1 has a key role in migration to peripheral lymph nodes (pLNs), and influences migration into other LNs...
  78. ncbi Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes-evidence for breakage-fusion-bridge cycles in the cytokinesis-block micronucleus assay
    Michael Fenech
    CSIRO Health Sciences and Nutrition, Genomic Stability Project, P O Box 10041, Adelaide BC, Australia
    Mutat Res 504:131-6. 2002
    ..b>Lymphocytes from 20 subjects were cultured in medium containing 12-120 nM folic acid for 9 days...
  79. ncbi Expression of non-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function
    Koichiro Kawashima
    Department of Pharmacology, Kyoritsu College of Pharmacy, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Front Biosci 9:2063-85. 2004
    b>Lymphocytes express most components of the cholinergic system including acetylcholine (ACh), muscarinic and nicotinic ACh receptors (mAChRs and nAChRs, respectively), choline acetyltransferase (ChAT), high affinity choline transporter ..
  80. ncbi Complex I and ATP content deficiency in lymphocytes from Friedreich's ataxia
    Mohammad Mehdi Heidari
    Genetic Group, Science School, Tarbiat Modares University, Iran
    Can J Neurol Sci 36:26-31. 2009
    ..The expansion (GAA) repeat in the first intron causes decreased frataxin expression by interfering with transcription...
  81. pmc Peripheral blood lymphocyte/monocyte ratio at diagnosis and survival in classical Hodgkin's lymphoma
    Luis F Porrata
    Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Haematologica 97:262-9. 2012
    ..We, therefore, studied whether the peripheral blood absolute lymphocyte count/absolute monocyte count ratio at diagnosis affects survival in classical Hodgkin's lymphoma...
  82. doi Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in patients with operable colorectal cancer
    Hyuk Chan Kwon
    Department of Internal Medicine, Dong A University College of Medicine, Busan, Republic of Korea
    Biomarkers 17:216-22. 2012
    ..002 and p=0.001, respectively). The PLR was an independent prognostic factor of OS based on multivariate analysis (hazard ratio, 1.971; 95% confidence interval, 1.102-3.335; p=0.021)...
  83. doi Retinoic-acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation
    Timotheus Y F Halim
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada
    Immunity 37:463-74. 2012
    ..RORα-deficient, but not RORγt-deficient, mice lacked NH cells in all tissues, whereas all other lymphocytes, including RORγt(+) ILCs, were unaffected...
  84. pmc Validation of the pre-treatment neutrophil-lymphocyte ratio as a prognostic factor in a large European cohort of renal cell carcinoma patients
    M Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz MUG, Graz, Austria
    Br J Cancer 108:901-7. 2013
    ..Therefore, the aim of our study was the validation of the prognostic significance of NLR in a large cohort of RCC patients...
  85. pmc The ratio of monocytes to lymphocytes in peripheral blood correlates with increased susceptibility to clinical malaria in Kenyan children
    George M Warimwe
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    PLoS ONE 8:e57320. 2013
    ..A better understanding of the host factors associated with immunity to clinical malaria and the ability to sustain asymptomatic P. falciparum infection will aid the development of improved strategies for disease prevention...
  86. pmc A derived neutrophil to lymphocyte ratio predicts clinical outcome in stage II and III colon cancer patients
    G Absenger
    Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Auenbruggerplatz 15, Graz, Austria
    Br J Cancer 109:395-400. 2013
    ..In this study, we analysed the dNLR with clinical outcome in stage II and III colon cancer patients...
  87. doi In vitro genotoxicity testing using the micronucleus assay in cell lines, human lymphocytes and 3D human skin models
    Micheline Kirsch-Volders
    Laboratorium voor Cellulaire Genetica, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium
    Mutagenesis 26:177-84. 2011
    ....
  88. ncbi Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey
    Zeev Pancer
    Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nature 430:174-80. 2004
    ..Individual lymphocytes express a uniquely rearranged VLR gene in monoallelic fashion...
  89. doi Erythropoietin receptor is expressed on human peripheral blood T and B lymphocytes and monocytes and is modulated by recombinant human erythropoietin treatment
    Katarzyna A Lisowska
    Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland
    Artif Organs 34:654-62. 2010
    ..We decided to investigate possible expression of EPO-R on circulating peripheral blood lymphocytes and monocytes of CRF patients in order to assess the possibility of rhEPO direct action on these cells...
  90. pmc Moderate influence of human APOBEC3F on HIV-1 replication in primary lymphocytes
    Lubbertus C F Mulder
    Mount Sinai School of Medicine, Department of Medicine, The Global Health and Emerging Pathogens Institute, New York, New York 10029, USA
    J Virol 84:9613-7. 2010
    ..A3F) to dissect the relative contribution of A3F to the inhibition of HIV-1 replication in primary human lymphocytes (peripheral blood mononuclear cells [PBMCs])...
  91. doi Genetic polymorphisms of genes involved in DNA repair and metabolism influence micronucleus frequencies in human peripheral blood lymphocytes
    Varinderpal S Dhillon
    CSIRO Food and Nutritional Sciences, Gate 13, Kintore Avenue, PO Box 10041, Adelaide, South Australia 5000, Australia
    Mutagenesis 26:33-42. 2011
    ..One hundred and eleven publications linking MN frequency in peripheral blood lymphocytes to gene polymorphism were retrieved from PubMed...
  92. ncbi Expression of 8-oxoguanine DNA glycosylase 1 (OGG1) and the level of p53 and TNF-αlpha proteins in peripheral lymphocytes of patients with Alzheimer's disease
    Mateusz Dezor
    Laboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, Poland
    Folia Neuropathol 49:123-31. 2011
    ..the extent of oxidative DNA damage (levels of 8-oxo2dG) and expression of OGG1 and p53 and TNF-α proteins in lymphocytes of Alzheimer's disease (AD) patients and a control group...
  93. ncbi Lymphocyte trafficking across high endothelial venules: dogmas and enigmas
    Masayuki Miyasaka
    Laboratory of Molecular and Cellular Recognition, Osaka University Graduate School of Medicine, 2 2, Yamada oka, Suita 565 0871, Japan
    Nat Rev Immunol 4:360-70. 2004
  94. ncbi Elevated preoperative neutrophil to lymphocyte ratio predicts survival following hepatic resection for colorectal liver metastases
    K J Halazun
    HPB and Transplant Unit, St James s University Hospital, Leeds LS9 7TF, UK
    Eur J Surg Oncol 34:55-60. 2008
    ..An elevated NLR has been shown to be a prognostic indicator in primary colorectal malignancy. The aim of this study was to establish whether NLR predicts outcome in patients undergoing resection for colorectal liver metastasis...
  95. doi Normalization of A2A and A3 adenosine receptor up-regulation in rheumatoid arthritis patients by treatment with anti-tumor necrosis factor alpha but not methotrexate
    Katia Varani
    University of Ferrara, Ferrara, Italy
    Arthritis Rheum 60:2880-91. 2009
    To investigate A(1), A(2A), A(2B), and A(3) adenosine receptors in lymphocytes and neutrophils from patients with early rheumatoid arthritis (ERA) as well as from RA patients treated with methotrexate (MTX) or anti-tumor necrosis factor ..
  96. pmc Transcriptomic epidemiology of smoking: the effect of smoking on gene expression in lymphocytes
    Jac C Charlesworth
    Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX, USA
    BMC Med Genomics 3:29. 2010
    ..This investigation offers insights into system-wide pathological processes induced in response to cigarette smoke exposure by determining its influences at the gene expression level...
  97. ncbi The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment
    Q Ma
    The Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 10:463-71. 1999
    ..Mice reconstituted with CXCR4-deficient fetal liver cells have reduced donor-derived mature B lymphocytes in blood and lymphoid organs...
  98. ncbi A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    K Akashi
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Nature 404:193-7. 2000
    ....
  99. doi Graft-versus-leukemia effects of transplantation and donor lymphocytes
    Hans Jochem Kolb
    Department of Medicine 3, Hematopoietic Cell Transplantation, University of Munich and Helmholtz Zentrum Muenchen National Research Centre for Environmental Health, Munich, Germany
    Blood 112:4371-83. 2008
    ..Allogeneic lymphocytes produce a strong graft-versus-leukemia (GVL) effect, but the beneficial effect is limited by graft-versus-host ..
  100. doi IL-17-producing T lymphocytes in lung tissue and in the bronchoalveolar space after exposure to endotoxin from Escherichia coli in vivo--effects of anti-inflammatory pharmacotherapy
    Olof Prause
    Department of Internal Medicine Respiratory Medicine and Allergology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Bruna Stråket 11b, S 413 45 Gothenburg, Sweden
    Pulm Pharmacol Ther 22:199-207. 2009
    ..However, little is known about its production in T lymphocytes in comparison with other cells, in lung tissue and in the bronchoalveolar space in vivo...
  101. doi Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma
    D Gomez
    Hepatobiliary and Transplantation Unit, The Leeds Teaching Hospitals NHS Trust, St James s University Hospital, Beckett Street, Leeds, LS9 7TF, UK
    World J Surg 32:1757-62. 2008
    ..This study was designed to evaluate the impact of an elevated preoperative neutrophil-to-lymphocyte ratio (NLR) on outcome after curative resection for hepatocellular carcinoma (HCC)...

Research Grants74

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  2. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
    ..Inflammatory cell invasion is characterized by invading adventitial and medial dendritic cells, macrophage, T lymphocytes, specifically T helper 1 (TH1) subpopulations, and giant cells, with attendant elastic layer degradation...
  3. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..contributes to the systemic inflammatory response through the production of, and recirculation of, TH2-like lymphocytes, eosinophils, basophils, and fibrocytes;and that those cells in turn influence sinus associated lymphatic ..
  4. MERVYN N WEITZMANN; Fiscal Year: 2016
    ..We hypothesize that "Lymphocytes, through B cell OPG production, and modulated by T cell costimulation, are critical regulators of basal bone ..
  5. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..of NGF/NGF-R in psoriatic disease we will investigate whether injection of NGF and NGF activated autologus T lymphocytes induce psoriasis in nonlesional skin transplant in the SCID mouse-human skin xenograft model...
  6. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..Several studies have shown that strong CD8+ cytotoxic T lymphocytes (CTL) responses may be elicited by infection or vaccine candidates, which may correlate with marginal decreases ..
  7. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ..well as genes encoding proteins- Gzmb and Prf1-that are expressed by neutrophils, macrophages and cytotoxic T-lymphocytes that infiltrate the lung during systemic inflammatory states such as T/HS...
  8. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..Monocytes and activated T lymphocytes dominate the early inflammatory infiltrates...
  9. Retinoid and Carotenoid Depletion in Patients at High-Risk for Liver Cancer
    Peter H Gann; Fiscal Year: 2010
    ..damage to DNA via 8OHdG in urine (oxidized, excreted DNA bases) and the comet assay (DNA strand breaks in lymphocytes) to test the association of these markers with serum antioxidant levels...
  10. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
    ..that respond to CR and certain mADF regimens include global cell proliferation (mammary, prostate, skin, liver, lymphocytes), adipose tissue dynamics and fat distribution, insulin sensitivity, and vascular smooth muscle cell ..
  11. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
    ..is characterized by airway hyperreactivity (AHR), inflammatory infiltrates containing eosinophilic leukocytes, lymphocytes, and mast cells, increased mucus secretion, and elevated serum IgE levels...
  12. Mitchell Kronenberg; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Regulatory CD4 T lymphocytes (Treg) are critical for the maintenance of self-tolerance...
  13. GENETIC ANALYSIS OF POLARITY
    RUTH M STEWARD; Fiscal Year: 2010
    ..In some lymphomas, PDCD2 is present in the cytoplasm of normal lymphocytes, but is not detected in malignant lymphocytes, indicating that the gene may have similar function in cell ..
  14. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
    ..parallels in muscle and the immune system, include SCID, a familial immune defect that combines loss of SOCE in lymphocytes and a myogenic myopathy...
  15. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    ..The ability of DVs to infect immune cells has resulted in many studies on infection of peripheral blood lymphocytes (PBLs) and their chemokine responses...
  16. Thalachallour Mohanakumar; Fiscal Year: 2015
    ..The overall goal of this proposal is to employ a safe and effective treatment regimen that targets B lymphocytes prior to and following LTx with the goal of reducing or removing Abs to self-Ags and HLA...
  17. Cellular Immunity to Category A-C Viruses in Humans
    ROBERT WILLIAM FINBERG; Fiscal Year: 2013
    ..CTRHIB) is a broad-based interdepartmental program to address, as its overall scientific theme, the role of T lymphocytes n the immunopathogenesis of and protection from category A-C viral pathogens in humans...
  18. Farrah Kheradmand; Fiscal Year: 2016
    ..lung tissue examined in subjects with emphysema is enriched with T helper type 1 (Th1) cells, CD4+ and CD8+ T lymphocytes that secrete cytokines such as interleukin 2 (IL-2), and interferon gamma (IFN-g)...
  19. Present Homologous and Heterologous Antigen with Hepatitis E Virus
    R Holland Cheng; Fiscal Year: 2012
    ..Advantages of DNA vaccines including well-tolerance, safety and ability to induce antibody, cytotoxic T- lymphocytes, and T-helper immune responses make it more and more attractive in treatment of chronic virus infections...
  20. PATHOPHYSIOLOGY OF THE ENDOTHELIUM
    Francis W Luscinskas; Fiscal Year: 2013
    ..mechanisms by which endothelium selectively regulates recruitment of the IL17- and IFN-y producing subsets of T lymphocytes into tissues...
  21. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..In AIDS patients, the lack of PDC in the circulation, along with depletion of CD4 T-lymphocytes is associated with the development of opportunistic infections, including viral infections...
  22. Clifford A Lowell; Fiscal Year: 2016
    ..Mutation of the SHP-1 gene (Ptpn6) results in severely hyperactive lymphocytes, myeloid cells and platelets...
  23. Autoimmunity Center of Excellence (ACE) at Stanford
    CHARLES GARRISON FATHMAN; Fiscal Year: 2013
    ..Project to study a new T cell lineage (termed Th17 cells) that is characterized by the ability of these lymphocytes to secrete high levels of the proinflammatory cytokine interleukin-17 (IL-17)...
  24. Keith T Wilson; Fiscal Year: 2016
    ..and gastritis;B) GMac phenotype and function;and C) Adaptive immunity in gastric tissues, splenocytes, and lymphocytes. 2.) To determine if effects of Arg2 are mediated by downstream polyamines...
  25. Non-coding RNA engineers antibody diversity
    Uttiya Basu; Fiscal Year: 2011
    ..Antibodies are polypeptide complexes produced from B-lymphocytes that are present in the bodily fluids of vertebrates, and are used by the immune system to identify and ..
  26. PEARLIE K BURNETTE; Fiscal Year: 2016
    Abstract: Clonal diseases of large granular lymphocytes (LGL) are characterized by lymphocytosis and T cell-mediated cytopenias of the myeloid compartment...
  27. In Vivo Function of TRAF6 As a Target of K63-Linked Polyubiquitination
    DEAN BALLARD; Fiscal Year: 2010
    ..and CD40, TNFR family members involved in the differentiation and effector functions of osteoclasts and B lymphocytes, respectively...
  28. Mucosal Memory T Cells at the Vanguard of Human Host Defense
    Donna L Farber; Fiscal Year: 2010
    ..sites by taking a novel, "whole-body" approach to investigate the functional potential and regulation of T lymphocytes in mucosal sites, by analyzing memory T cells in healthy mucosal and lymphoid tissues obtained from individual ..
  29. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010
    ..factors produced as a result of substance P release recruit neutrophils, monocytes, macrophages, and lymphocytes to the local site...
  30. Molecular Epidemiology of DNA Repair in Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2012
    ..Our specific aims are: AIM 1: To determine the association between the apoptotic phenotype of lymphocytes and risk of SCCHN in 600 prospectively identified cases and 600 hospital-based controls frequency matched by ..
  31. Knockdown of Gene Expression in Immune Cells in Humanized Mice
    Judy Lieberman; Fiscal Year: 2010
    ..for in vivo studies is delivering small RNAs across the plasma membrane, which is especially challenging for lymphocytes, which are both a moving target and resistant to transduction...
  32. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..lung tissue examined in subjects with emphysema is enriched with T helper type 1 (Th1) cells, CD4+ and CD8+ T lymphocytes that secrete cytokines such as interleukin 2 (IL-2), and interferon gamma (IFN?)...
  33. Henryk F Urbanski; Fiscal Year: 2014
    ..Finally, we will examine the impact of androgen supplementation on the homeostasis of tissue resident lymphocytes by determining 1) T and B cell subset distribution in bone marrow, lymph nodes, bronchoalveolar lavage, and gut ..
  34. Mindfulness Based Stress Reduction as an Adjunctive Treatment for Psoriasis
    Jan A Moynihan; Fiscal Year: 2013
    ..epithelium (acanthosis) with infiltration of neutrophils and CD4+ (helper) and CD8+ (cytotoxic/suppressor) lymphocytes, as well as growth and dilation of blood vessels in the papillary dermis with CD4+ lymphocytes...
  35. Vernon K Sondak; Fiscal Year: 2016
    ..the way for larger randomized phase II or phase III trials of adoptive immunotherapy with tumor infiltrating lymphocytes to support the inclusion of BRAF agents with this promising therapy, based on innovative approaches for how ..
  36. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..for the pathogenesis of psoriatic disease because of their memory phenotype and the ability of activated T lymphocytes to induce psoriasis in transplanted nonlesional skin in the SCID mouse-human skin xenograft model...
  37. Chemokine Decoy Receptor for Therapy of Autoimmune Arthritis
    Kanneganti Murthy; Fiscal Year: 2012
    ..formation, and gross and histologic injury scores, and on draining lymph node populations of Th1 and Treg lymphocytes. PUBLIC HEALTH RELEVANCE: Rheumatoid arthritis is a devastating autoimmune disease characterized by lifelong ..
  38. Identifying underlying mechanisms of intracellular changes in response to caregiv
    MELANIE SARAH FLINT; Fiscal Year: 2013
    ..of its kind to molecularly analyze psychological stress effects on the comprehensive proteome of circulating T lymphocytes in humans...
  39. MUCOSAL DEFENSE MECHANISMS IN SUBSTANCE ABUSE
    David R Brown; Fiscal Year: 2010
    ..Aim 3, we will characterize delta-opioid receptors mediating chemokine-induced chemotaxis of intestinal T lymphocytes, and determine the effects of opioids on neurally-mediated secretory immunoglobulin-A release from intestinal ..
  40. Herpesvirus-induced telomerase dysregulation and tumor formation
    Keith William Jarosinski; Fiscal Year: 2011
    ..It will also address the mechanism of herpesvirus integration into the host genome and its importance for latent infection and transformation of lymphocytes.
  41. Fnip1 Function in Lymphocyte Development, Activation and Metabolism
    Brian M Iritani; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Project Summary Relative to resting lymphocytes, both activated lymphocytes and cancer cells exhibit a unique shift in cell metabolism from oxidative phosphorylation, which efficiently produces energy,..
  42. NANCIE MACIVER; Fiscal Year: 2014
    ..membrane protein CD28;that leptin activates the metabolic mediator AMP-activated protein kinase (AMPK) in lymphocytes;and that leptin is necessary for glucose uptake in activated cells...
  43. A novel allele influencing HIV infection among injection drug users
    Xiao Fang Yu; Fiscal Year: 2012
    ..APOBEC3 cytidine deaminases such as A3B are highly expressed in human T lymphocytes and macrophages...
  44. Genome-wide DNA Methylation Profiles Associated with Abnormal Intrauterine Growth
    Cristina Montagna; Fiscal Year: 2013
    ..and biologically relevant loci for evaluation of functional significance and comparison in other cell types (lymphocytes and leukocytes from umbilical cord and maternal peripheral blood and umbilical vein endothelial cells)...
  45. John D Mountz; Fiscal Year: 2016
    ..This proposal will analyze specific molecular pathways that interact in lymphocytes leading to the formation of germinal centers...
  46. CD4+ T cells in Invasive Aspergillosis
    Amariliz Rivera; Fiscal Year: 2012
    ..goals of the studies proposed in this K22 application are centered in understanding and exploiting CD4 T lymphocytes in defense against fungal disease...
  47. Paul M Lieberman; Fiscal Year: 2015
    ..Long-term latent infection in B-lymphocytes and persistent infection in endothelial cells is thought to be a major driving force for KSHV-associated ..
  48. Stem Cell Based Therapy For Radiation Induced Gastrointestinal Syndrome
    Chandan Guha; Fiscal Year: 2010
    ..of supporting cells, such as mesenchymal-derived cells, microvascular endothelial cells, macrophages and lymphocytes. These stromal cells provide the niche and could supply critical growth factor/signals for ISC regeneration...
  49. Yale Autoimmunity Center of Excellence
    Kevan C Herold; Fiscal Year: 2013
    ..A pilot study is proposed in which new technologies will be developed to visualize lymphocytes in vivo and humanized mice as a prelude to clinical investigations...
  50. Organismal Radioprotection Through Pharmacological Quiescence
    JOHN S CHANT; Fiscal Year: 2010
    ..enhancing survival and protecting all blood lineages including red cells, platelets, granulocytes and lymphocytes. G-Zero has licensed broad intellectual property surrounding the use of PQ for radioprotection...
  51. Trophoblast MHC-I: Trigger for Immune-Mediated Rejection of Cloned Bovine Fetuses
    Kenneth L White; Fiscal Year: 2011
    ..fetuses, express classical major histocompatibility complex class I (MHC-I) antigens early in pregnancy, (2) T lymphocytes accumulate in the uterine stroma of SCNT recipients, and (3) MHC homozygous SCNT fetuses fare better than MHC ..
  52. Phospholipid flip-flop in biogenic membranes
    Anant K Menon; Fiscal Year: 2013
    ..membrane expands and glycoprotein secretion increases;this occurs, for example, during the differentiation of B-lymphocytes to antibody-secreting plasma B cells...
  53. Regulation of the VDJ recombinase during genotoxic stress
    Karla K Rodgers; Fiscal Year: 2013
    ..b>Lymphocytes undergoing genotoxic stress would be at a greater risk of forming such deleterious chromosomal translocations, ..
  54. A Novel Model of, and Pre-clinical Therapy for, Scleroderma Lung Disease
    Sergei P Atamas; Fiscal Year: 2012
    ..mouse (m) IL-442 to mouse lung in vivo recapitulates important features of human SLD, causing infiltration of lymphocytes, disturbances in cytokine milieu, and a tendency to collagen accumulation...
  55. Lina Lu; Fiscal Year: 2014
    ..The lymphocytes and graft infiltrating cells can be recovered for further analysis...
  56. Xiaoxia Li; Fiscal Year: 2015
    ..inflammatory diseases, including the initiation stage (activation and expansion of neuroantigen-reactive CD4 T lymphocytes outside of CNS) and effector stage (recruitment and reactivation of neuroantigen-reactive CD4 T lymphocytes and ..
  57. Michael D Cahalan; Fiscal Year: 2016
    ..entry (SOCE) underlies numerous cellular processes throughout the body and initiates signaling cascades in T lymphocytes that cause changes in motility, secretion of cytolytic granules, cytokine release, and cell proliferation...
  58. Prevention of acute GvHD by inhibition of cdk2
    Vassiliki A Boussiotis; Fiscal Year: 2012
    ..While cdk2 is essential for expansion of activated T cells, it is not critical for survival of resting lymphocytes, hematopoiesis or thymocyte development...
  59. Antigen receptor inputs: linking structural, molecular, and cellular responses
    Jonathan P Schneck; Fiscal Year: 2012
    ..Activation of lymphocytes through specific recognition of antigen poses narrowly balanced benefits and risks, and hence is subject to ..
  60. NFAT Signaling and Down Syndrome
    Gerald R Crabtree; Fiscal Year: 2012
    ..Initially we will determine if samples from DS human fetuses, cord blood hematopoietic stem cells and T lymphocytes have the expected biochemical and genetic features of reduced NFAT activity and reduced target gene activation...
  61. NANCY DEMORE; Fiscal Year: 2014
    ..Tacrolimus (FK506) is an immunosuppressive drug that binds to the immunophlin FKBP12 in lymphocytes. The FK506-FKBP12 complex associates with calcineurin and inhibits its phosphatase activity, which inhibits ..
  62. Kafait U Malik; Fiscal Year: 2016
    ..cPLA2[unreadable] gene disruption also ameliorates Ang II-induced renal infiltration of macrophages and T lymphocytes, suggesting alterations in hypertension-induced immune system activation...
  63. DNA Repair Capacity and Risk of Pre-malignant Lesion in Lung Epithelium
    Hua Zhao; Fiscal Year: 2009
    ..To achieve this goal, we will apply mutagen sensitivity assay to quantify levels of H2O2 induced 8-OH-dG in lymphocytes reflecting systemic BER capacity...
  64. Signaling in Thymocyte Selection
    Gerald R Crabtree; Fiscal Year: 2010
    ..Investigator (Last, Middle) : Crabtree , Gerald 2 ROl E-, A1060037-06 AI060037 -06 shape repertoire lymphocytes has been one the most The mechanisms that shape the repertoire of T lymphocytes has been one of the most ..
  65. Immunoglobulin Somatic Mutation
    Ursula Storb; Fiscal Year: 2007
    The process of somatic hypermutation (SHM) of immunoglobulin (Ig) genes takes place in B lymphocytes after specific interaction with antigen and T lymphocytes. SHM has several steps and requirements...
  66. 1,25 DIHYDROXY VITAMIN D3 AND CELLULAR IMMUNITY
    Stavros Manolagas; Fiscal Year: 1991
    It is well established that monocytes and activated lymphocytes express the receptor for 1,25 dihydroxyvitamin D3 (1,25(OH)2D3); and that 1,25(OH)2D3, acting via its receptor can modulate the proliferation of lymphocytes as well as the ..
  67. XENOGENEIC MODEL FOR HOMING OF HUMAN LYMPHOCYTES
    Sharon Evans; Fiscal Year: 1993
    ..immunodeficient (SCID) mice to serve as an in vivo model to study mechanisms involved in homing of human lymphocytes. Lymphocyte migration into peripheral lymph nodes is initiated by the interaction of the L-selectin homing ..
  68. EFFECTS OF PHORBOL ESTERS ON LYMPHOCYTE STIMULATION
    Andrea Mastro; Fiscal Year: 1991
    Primary lymphocytes are an excellent model for studying cell division. Unlike cell lines, lymphocytes remain in Go until stimulated...
  69. Specialized Centers for Cell-Based Therapy for NHLBI an*
    Shelly Carter; Fiscal Year: 2009
    ..There are a broad range of products and proposed indications for use including tumor-infiltrating lymphocytes, activated T lymphocytes for treatment of viral infections, a marketed cartilage cellular product for treatment ..
  70. HIV-1 Specific Cytotoxic T Lymphocytes in Breastmilk
    Grace John Stewart; Fiscal Year: 2003
    ..Some uninfected infants born to HIV-1 infected women generate HIV-1 specific cytotoxic T lymphocytes (CTLs), suggesting viral antigenic exposure sufficient to induce immunity but not to establish infection...
  71. Measurement of CCR5 and CCL3L1 on Single Cell by Fluorescent Metal Nanoparticle
    Richard Yuqi Zhao; Fiscal Year: 2010
    Presence of the CC-chemokine co-receptors CCR5 on the cell surface of CD4+ T-lymphocytes is necessary for successful HIV-1 infection...