leukocytes

Summary

Summary: White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).

Top Publications

  1. ncbi Inflammation in atherosclerosis
    Peter Libby
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 420:868-74. 2002
  2. ncbi Leukocyte telomere length and cardiovascular disease in the cardiovascular health study
    Annette L Fitzpatrick
    Department of Epidemiology, School of Public Health and Community Medicine, Collaborative Health Studies Coordinating Center, University of Washington, Seattle, WA 98115, USA
    Am J Epidemiol 165:14-21. 2007
  3. pmc Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Proc Natl Acad Sci U S A 107:9293-8. 2010
  4. doi Cancer-related inflammation
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, Rozzano, 20089 Milan, Italy
    Nature 454:436-44. 2008
  5. ncbi Inflammatory cells during wound repair: the good, the bad and the ugly
    Paul Martin
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK BS8 1TD
    Trends Cell Biol 15:599-607. 2005
  6. pmc Structural basis of integrin regulation and signaling
    Bing Hao Luo
    The CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 25:619-47. 2007
  7. pmc Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR
    Abraham Aviv
    The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Nucleic Acids Res 39:e134. 2011
  8. doi The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models
    Christian Weber
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, 52074 Aachen, Germany
    Nat Rev Immunol 8:802-15. 2008
  9. doi Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset
    Philippe A Melas
    Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden
    FASEB J 26:2712-8. 2012
  10. doi Are bloodstream leukocytes Trojan Horses for the metastasis of Staphylococcus aureus?
    Guy E Thwaites
    Centre for Molecular Microbiology and Infection, Imperial College, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Nat Rev Microbiol 9:215-22. 2011

Research Grants

Detail Information

Publications320 found, 100 shown here

  1. ncbi Inflammation in atherosclerosis
    Peter Libby
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 420:868-74. 2002
    ..Identifying the triggers for inflammation and unravelling the details of inflammatory pathways may eventually furnish new therapeutic targets...
  2. ncbi Leukocyte telomere length and cardiovascular disease in the cardiovascular health study
    Annette L Fitzpatrick
    Department of Epidemiology, School of Public Health and Community Medicine, Collaborative Health Studies Coordinating Center, University of Washington, Seattle, WA 98115, USA
    Am J Epidemiol 165:14-21. 2007
    ..22, 95% confidence interval: 1.29, 8.02). These results support the hypotheses that telomere attrition may be related to diseases of aging through mechanisms involving oxidative stress, inflammation, and progression to CVD...
  3. pmc Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Proc Natl Acad Sci U S A 107:9293-8. 2010
    ....
  4. doi Cancer-related inflammation
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, Rozzano, 20089 Milan, Italy
    Nature 454:436-44. 2008
    ..The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment...
  5. ncbi Inflammatory cells during wound repair: the good, the bad and the ugly
    Paul Martin
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK BS8 1TD
    Trends Cell Biol 15:599-607. 2005
    ....
  6. pmc Structural basis of integrin regulation and signaling
    Bing Hao Luo
    The CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 25:619-47. 2007
    ..In this review, we focus on integrin structure as it relates to affinity modulation, ligand binding, outside-in signaling, and cell surface distribution dynamics...
  7. pmc Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR
    Abraham Aviv
    The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Nucleic Acids Res 39:e134. 2011
    ..We discuss the ramifications of these findings with regard to measurements of telomere length/DNA content in epidemiological/clinical circumstances...
  8. doi The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models
    Christian Weber
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, 52074 Aachen, Germany
    Nat Rev Immunol 8:802-15. 2008
    ..Improved understanding of the selective contributions of specific cell types to atherogenesis will pave the way for new targeted approaches to therapy...
  9. doi Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset
    Philippe A Melas
    Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden
    FASEB J 26:2712-8. 2012
    ..Analyses were conducted using DNA from leukocytes of patients with schizophrenia and controls...
  10. doi Are bloodstream leukocytes Trojan Horses for the metastasis of Staphylococcus aureus?
    Guy E Thwaites
    Centre for Molecular Microbiology and Infection, Imperial College, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Nat Rev Microbiol 9:215-22. 2011
    ..Furthermore, we suggest how this can be experimentally confirmed and how it may prompt a change in the current paradigm of S. aureus bacteraemia and identify better treatment options for improved clinical outcomes...
  11. pmc Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS
    Rhonda R Voskuhl
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 29:11511-22. 2009
    ..Reactive astrocytes have been implicated in restricting the spread of leukocytes from damaged into healthy parenchyma during the acute and local innate inflammatory events that follow CNS ..
  12. pmc Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings
    Owen M Wolkowitz
    Department of Psychiatry, University of California San Francisco School of Medicine, San Francisco, California, United States of America
    PLoS ONE 6:e17837. 2011
    ..We sought to determine if leukocyte telomeres are shortened in Major Depressive Disorder (MDD), whether this is a function of lifetime depression exposure and whether this is related to putative mediators, oxidation and inflammation...
  13. pmc Selective upregulation of microRNA expression in peripheral blood leukocytes in IL-10-/- mice precedes expression in the colon
    Jeremy S Schaefer
    Department of Diagnostic Sciences, Dental Branch, The University of Texas Health Science Center at Houston, TX 77030, USA
    J Immunol 187:5834-41. 2011
    ..mice at a time when colonic inflammation was minimal, suggesting that changes in specific miRNAs in circulating leukocytes may be harbingers of ensuing colonic pathology...
  14. pmc Gene expression patterns in blood leukocytes discriminate patients with acute infections
    Octavio Ramilo
    Baylor National Institute of Allergy and Infections Diseases NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense and Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Blood 109:2066-77. 2007
    ..Thus, microarray analyses of patient peripheral blood leukocytes might assist in the differential diagnosis of infectious diseases.
  15. ncbi A network-based analysis of systemic inflammation in humans
    Steve E Calvano
    Department of Surgery, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Nature 437:1032-7. 2005
    ..These findings provide insight into the regulation of global leukocyte activities as they relate to innate immune system tolerance and increased susceptibility to infection in humans...
  16. doi Telomere length and risk of incident cancer and cancer mortality
    Peter Willeit
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    JAMA 304:69-75. 2010
    ..Telomeres are essential to preserve the integrity of the genome. Critically short telomeres lead to replicative cell senescence and chromosomal instability and may thereby increase cancer risk...
  17. pmc CD11c- and CD11b-expressing mouse leukocytes transport single Toxoplasma gondii tachyzoites to the brain
    Nathalie Courret
    Departement des Maladies Infectieuses, Institut Cochin, Institut National de la Santé et de la Recherche Médicale U567 Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, 22 rue Mechain, 75014 Paris, France
    Blood 107:309-16. 2006
    ..We investigated the role of CD11c- and CD11b-expressing leukocytes in T...
  18. pmc Human cytomegalovirus UL131-128 genes are indispensable for virus growth in endothelial cells and virus transfer to leukocytes
    Gabriele Hahn
    Max von Pettenkofer Institut, Abteilung Virologie, Ludwig Maximilians Universitat Munchen, Munich, Germany
    J Virol 78:10023-33. 2004
    ..However, the genetic basis of HCMV growth in endothelial cells and transfer to leukocytes is unknown...
  19. doi Breaching multiple barriers: leukocyte motility through venular walls and the interstitium
    Sussan Nourshargh
    Barts and the London School of Medicine and Dentistry, Queen Mary University of London, William Harvey Research Institute, Charterhouse Square, London, UK
    Nat Rev Mol Cell Biol 11:366-78. 2010
    The shuttling of leukocytes between the bloodstream and interstitial tissues involves different locomotion strategies that are governed by locally presented soluble and cell-bound signals...
  20. pmc Nipah virus uses leukocytes for efficient dissemination within a host
    Cyrille Mathieu
    INSERM, U758, Ecole Normale Superieure de Lyon, Lyon, F 69007 France
    J Virol 85:7863-71. 2011
    ..In NiV-infected hamsters, leukocytes captured and carried NiV after intraperitoneal infection without themselves being productively infected...
  21. pmc Synchrony of telomere length among hematopoietic cells
    Masayuki Kimura
    The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Exp Hematol 38:854-9. 2010
    ..This information is relevant because telomere dynamics in granulocytes were postulated to mirror those of hematopoietic stem cells (HSCs)...
  22. ncbi Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes
    Yuh Chiang Shen
    National Research Institute of Chinese Medicine, Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Eur J Pharmacol 465:171-81. 2003
    ..PMA)- or N-formyl-methionyl-leucyl-phenylalanine (fMLP)-activated inflammatory responses of peripheral human leukocytes were studied...
  23. ncbi Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity
    A Benetos
    Center Investigations Preventives et Cliniques, INSERM U337, Paris, France
    Hypertension 37:381-5. 2001
    ..The longer telomere length in women suggests that for a given chronological age, biological aging of men is more advanced than that of women...
  24. pmc Physical activity, sedentary behavior, and leukocyte telomere length in women
    Mengmeng Du
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Epidemiol 175:414-22. 2012
    ..Telomere length in peripheral blood leukocytes, collected in 1989-1990, was measured by quantitative polymerase chain reaction...
  25. doi Short telomeres in depression and the general population are associated with a hypocortisolemic state
    Mikael Wikgren
    Division of Psychiatry, Department of Clinical Sciences, Umea University, Umea, Sweden
    Biol Psychiatry 71:294-300. 2012
    ..We aimed to study the relationships between TL and biological and psychological facets of stress in recurrent major depressive disorder and controls...
  26. pmc Global methylation profiles in DNA from different blood cell types
    Hui Chen Wu
    Department of Epidemiology, Mailman School of Public Health of Columbia University, New York, NY, USA
    Epigenetics 6:76-85. 2011
    ..39-0.64). Results from the LUMA assay were modestly correlated with LINE1 (0.18-0.20). These results suggest that both assay and source of DNA are critical components in the interpretation of global DNA methylation patterns from WBC...
  27. pmc Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
    Matthew Spite
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 461:1287-91. 2009
    ..Together, these results identify RvD2 as a potent endogenous regulator of excessive inflammatory responses that acts via multiple cellular targets to stimulate resolution and preserve immune vigilance...
  28. ncbi Telomere length in the newborn
    Koji Okuda
    The Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    Pediatr Res 52:377-81. 2002
    ....
  29. pmc TRAIL-coated leukocytes that kill cancer cells in the circulation
    Michael J Mitchell
    Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853
    Proc Natl Acad Sci U S A 111:930-5. 2014
    ..a unique approach to target and kill colon and prostate cancer cells in the blood that causes circulating leukocytes to present the cancer-specific TNF-related apoptosis inducing ligand (TRAIL) on their surface along with E-..
  30. ncbi Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia
    Jeffrey M Gidday
    Dept of Neurosurgery, Washington Univ School of Medicine, 660 S Euclid Ave, Box 8057, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 289:H558-68. 2005
    ..In the present study, we used MMP-9-/- mice and chimeric knockouts lacking either MMP-9 in leukocytes or in resident brain cells to test the hypothesis that MMP-9 released from leukocytes recruited to the brain ..
  31. ncbi Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response
    William A Muller
    Department of Pathology, and Laboratory Medicine, Graduate Program in Immunology, Weill Medical College, 1300 York Avenue, New York, NY 10021, USA
    Trends Immunol 24:327-34. 2003
    Both the innate and adaptive immune responses are dependent on the migration of leukocytes across endothelial cells...
  32. ncbi Human telomere biology: pitfalls of moving from the laboratory to epidemiology
    Abraham Aviv
    The Center of Human Development and Aging of New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Int J Epidemiol 35:1424-9. 2006
    ..Here we explain some of the reasons for this variability and propose several principles that should be considered in conducting epidemiological telomere research. Ignoring these principles could lead to misleading conclusions...
  33. pmc Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation
    Sungwhan F Oh
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115 5727, USA
    J Clin Invest 121:569-81. 2011
    ....
  34. pmc Energy intake and leukocyte telomere length in young adults
    Jeremy D Kark
    Hebrew University Hadassah School of Public Health and Community Medicine, Ein Kerem, Jerusalem, Israel
    Am J Clin Nutr 95:479-87. 2012
    ..Dietary energy restriction in mammals, particularly at a young age, extends the life span. Leukocyte telomere length (LTL) is thought to be a bioindicator of aging in humans. High n-6 (omega-6) PUFA intake may accelerate LTL attrition...
  35. pmc Yogic meditation reverses NF-κB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial
    David S Black
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA
    Psychoneuroendocrinology 38:348-55. 2013
    ..The present study examined if a yogic meditation might alter the activity of inflammatory and antiviral transcription control pathways that shape immune cell gene expression...
  36. doi A miRNA signature in leukocytes from sporadic amyotrophic lateral sclerosis
    Bruna De Felice
    Department of Life Sciences, University of Naples II, Via Vivaldi 43, 81100 Caserta, Italy
    Gene 508:35-40. 2012
    ..Here, we analyzed the expression profiles of 911 human miRNAs using microarray technology in leukocytes, the most readily available human tissue cells, obtained from 8 patients affected by sporadic amyotrophic ..
  37. ncbi Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients
    Joan H Pedersen-Lane
    Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201 0509, USA
    J Leukoc Biol 81:934-41. 2007
    ..Flow cytometry was used to evaluate the thiol status [surface-thiols and intracellular glutathione (iGSH)] of leukocytes from RA patients and controls...
  38. pmc Prenatal arsenic exposure and DNA methylation in maternal and umbilical cord blood leukocytes
    Molly L Kile
    Oregon State University, College of Public Health and Human Sciences, Corvallis, Oregon 97331, USA
    Environ Health Perspect 120:1061-6. 2012
    ..Arsenic is an epigenetic toxicant and could influence fetal developmental programming...
  39. pmc Associations between diet, lifestyle factors, and telomere length in women
    Aedin Cassidy
    School of Medicine, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 91:1273-80. 2010
    ..Leukocyte telomere length is associated with diseases of aging, but there is limited knowledge of diet and lifestyle determinants...
  40. pmc Leukocyte-mediated endothelial cell injury and death in the diabetic retina
    A M Joussen
    Laboratory for Surgical Research, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Pathol 158:147-52. 2001
    ..The current study demonstrates that adherent leukocytes are temporally and spatially associated with retinal endothelial cell injury and death within 1 week of ..
  41. pmc Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study
    Abraham Aviv
    The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Am J Epidemiol 169:323-9. 2009
    ..These findings underscore the complexity of leukocyte telomere dynamics in vivo and suggest that determinants in addition to the "end-replication problem" contribute to telomere shortening in vivo...
  42. ncbi Rise in insulin resistance is associated with escalated telomere attrition
    Jeffrey P Gardner
    Hypertension Research Center, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Circulation 111:2171-7. 2005
    ..We therefore tested the hypothesis that a rise in insulin resistance in concert with gain in body mass is associated with accelerated white blood cell telomere attrition...
  43. ncbi Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients
    Larissa Dyugovskaya
    Unit of Anatomy and Cell Biology and Sleep Laboratory, Technion Israel Institute of Technology, The Bruce Rappaport Faculty of Medicine, Haifa, Israel
    Am J Respir Crit Care Med 165:934-9. 2002
    ..Therefore, we investigated the link between CD15, CD11c, CD11b, and CD64 expression on leukocytes and their ability to generate reactive oxygen species (ROS) in patients with OSA and control volunteers...
  44. ncbi The effects of social status on biological aging as measured by white-blood-cell telomere length
    L F Cherkas
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK, and The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103 2714, USA
    Aging Cell 5:361-5. 2006
    ..Comparison of TRFL in the 17 most discordant SES twin pairs confirmed this difference. Low SES, in addition to the harmful effects of smoking, obesity and lack of exercise, appears to have an impact on telomere length...
  45. doi Chemokines in the vascular inflammatory response of atherosclerosis
    Alma Zernecke
    Institute for Molecular Cardiovascular Research, University Hospital Aachen, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Cardiovasc Res 86:192-201. 2010
    ..In addition, we will discuss recent developments scrutinizing heterophilic interactions of chemokines that have advanced our understanding of how chemokines control vascular inflammatory responses...
  46. pmc Telomere length and mortality: a study of leukocytes in elderly Danish twins
    Masayuki Kimura
    Center of Human Development and Aging, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Am J Epidemiol 167:799-806. 2008
    Leukocyte telomere length, representing the mean length of all telomeres in leukocytes, is ostensibly a bioindicator of human aging...
  47. pmc DNA methylation as a biomarker for cardiovascular disease risk
    Myungjin Kim
    Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 5:e9692. 2010
    ..This may reflect a reduced systemic remethylation capacity, which would be expected to cause decreased genomic DNA methylation in peripheral blood leukocytes (PBL).
  48. ncbi Alteration of the copy number of mitochondrial DNA in leukocytes of patients with hyperlipidemia
    Chin San Liu
    Vascular and Genomic Research Center, Changhua Christian Hospital, Taiwan
    Ann N Y Acad Sci 1042:70-5. 2005
    Lipid metabolism in leukocytes may be disturbed by mitochondrial dysfunction caused by depletion of mitochondrial DNA (mtDNA) in response to an increase of oxidative stress in blood circulation...
  49. pmc Coregulation in human leukocytes of the long pentraxin PTX3 and TSG-6
    Virginia Maina
    Research Laboratory in Immunology and Inflammation, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    J Leukoc Biol 86:123-32. 2009
    ..The present study was designed to assess whether PTX3 and TSG-6 are coregulated in leukocytes, in particular, in phagocytes and DC...
  50. ncbi Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes
    J Fawcett
    ICRF Laboratories, University of Oxford, UK
    Nature 360:481-4. 1992
    ..endothelium; ICAM-1 is strongly upregulated by cytokine stimulation and plays a key role in the arrest of leukocytes in blood vessels at sites of inflammation and injury...
  51. pmc Differential infectivity and division of Toxoplasma gondii in human peripheral blood leukocytes
    J Y Channon
    Departments of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Infect Immun 68:4822-6. 2000
    When tachyzoites were incubated with human peripheral blood leukocytes in vitro, more monocytes and dendritic cells than neutrophils or lymphocytes were infected...
  52. doi Blood leucocyte telomere DNA content predicts vascular telomere DNA content in humans with and without vascular disease
    W Richard W Wilson
    Department of Surgery, University of Nottingham, Nottingham, UK
    Eur Heart J 29:2689-94. 2008
    ..We, thus, investigated the relationship between vascular wall and circulating leucocyte telomere length in humans with and without overt vascular disease...
  53. ncbi Endothelial cell glycocalyx modulates immobilization of leukocytes at the endothelial surface
    Alina A Constantinescu
    Department of Medical Physics, University of Amsterdam, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 23:1541-7. 2003
    ....
  54. ncbi Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines
    Kol A Zarember
    Department of Molecular Biology, Genentech Inc, South San Francisco, CA 94080, USA
    J Immunol 168:554-61. 2002
    ..Most tissues tested expressed at least one TLR, and several expressed all (spleen, peripheral blood leukocytes)...
  55. ncbi Getting to the site of inflammation: the leukocyte adhesion cascade updated
    Klaus Ley
    Robert M Berne Cardiovascular Research Center and Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Rev Immunol 7:678-89. 2007
    ..This Review focuses on new aspects of one of the central paradigms of inflammation and immunity--the leukocyte adhesion cascade...
  56. pmc Locally up-regulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malaria
    Christian R Engwerda
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    J Exp Med 195:1371-7. 2002
    ..expression on cerebral vasculature and the intraluminal accumulation of complement receptor 3 (CR3)-positive leukocytes was moderate. In contrast, mice deficient in LTalpha (B6...
  57. doi Cellular aging reflected by leukocyte telomere length predicts advanced atherosclerosis and cardiovascular disease risk
    Peter Willeit
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Arterioscler Thromb Vasc Biol 30:1649-56. 2010
    ..To determine the association between leukocyte telomere length (TL) and atherosclerosis and its clinical sequelae stroke and myocardial infarction...
  58. ncbi Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse
    Robert Hannon
    Department of Biochemical Pharmacology, William Harvey Research Institute, Queen Mary, University of London, Charterhouse Square, EC1M 6BQ, UK
    FASEB J 17:253-5. 2003
    ..polymorphonuclear leucocytes exhibited increased spontaneous migratory behavior in vivo whereas in vitro, leukocytes from Anx-1-/- mice had reduced cell surface CD 11b (MAC-1) but enhanced CD62L (L-selectin) expression and Anx-1-/..
  59. ncbi An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family
    Stefanie Ernst
    Institute for Medical Biochemistry, Center for Molecular Biology of Inflammation, Von Esmarch Strasse 56, D 48149 Munster, Germany
    J Immunol 172:7669-76. 2004
    ....
  60. pmc The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men
    Elissa S Epel
    University of California, San Francisco, Department of Psychiatry, San Francisco, CA, 94143, USA
    Aging (Albany NY) 1:81-8. 2008
    ..DNA samples from baseline and 2.5 years later were assayed for mean TL of leukocytes. Percent change in TL was calculated as a measure of TL change (TLC)...
  61. pmc Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study
    Steven C Hunt
    Cardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, UT, USA NHLBI Family Heart Study
    Aging Cell 7:451-8. 2008
    ..029 kb year(-1) vs. 0.020 kb year(-1), respectively, p = 0.0001). We suggest that racial difference in LTL arises from a host of interacting biological factors, including replication rates of hematopoietic stem cells...
  62. ncbi Accelerated wound healing in leukocyte-specific, protein 1-deficient mouse is associated with increased infiltration of leukocytes and fibrocytes
    Jianfei Wang
    Wound Healing Research Group Division of Plastic and Reconstructive Surgery and Critical Care, Department of Surgery, University of Alberta, Edmonton, Alberta T6G 2B7, Canada
    J Leukoc Biol 82:1554-63. 2007
    ..Further analysis of Lsp1(-/-) mice may suggest ways to improve wound healing and/or treat fibrotic conditions of skin and other tissue...
  63. pmc Association of telomere length of peripheral blood leukocytes with hematopoietic relapse, malignant transformation, and survival in severe aplastic anemia
    Phillip Scheinberg
    Hematology Branch, National Heart, Lung, and Blood Institute, 10 Center Dr, Bldg 10 CRC, Room 3 5140, MSC 1202, Bethesda, MD 20892 1202, USA
    JAMA 304:1358-64. 2010
    ..Variations in telomere length have been reported in severe aplastic anemia but their clinical significance is unknown...
  64. pmc Chemokine-like receptor-1 expression by central nervous system-infiltrating leukocytes and involvement in a model of autoimmune demyelinating disease
    Kareem L Graham
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 183:6717-23. 2009
    ..The results imply involvement of CMKLR1 in both the induction and effector phases of disease. We conclude that CMKLR1 participates in the inflammatory mechanisms of EAE and represents a potential therapeutic target in multiple sclerosis...
  65. ncbi The developmental changes in mitochondrial DNA content per cell in human cord blood leukocytes during gestation
    M Pejznochova
    Department of Pediatrics, Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 57:947-55. 2008
    ..Isolated human cord blood leukocytes (HCBL) contribute very little to the overall metabolic turnover, but they may serve as easily available marker ..
  66. pmc Nuclear factor kappa B modulates apoptosis in the brain endothelial cells and intravascular leukocytes of fatal cerebral malaria
    Chuchard Punsawad
    Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok, Thailand
    Malar J 12:260. 2013
    ..An important signaling factor, nuclear factor kappa B (NF-κB) is known to regulate apoptosis. This work aimed to study the expression of NF-κB p65 and its correlation with apoptosis in the brain of fatal CM...
  67. pmc Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: the Stockholm Atherosclerosis Gene Expression (STAGE) study
    Sara Hägg
    The Computational Medicine Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    PLoS Genet 5:e1000754. 2009
    ..Genes in the transendothelial migration of leukocytes (TEML) pathway were overrepresented in all three clusters, referred to as the atherosclerosis module (A-module)...
  68. ncbi Levels of 8-hydroxydeoxyguanosine as a marker of DNA damage in human leukocytes
    M Lodovici
    Department of Pharmacology, University of Florence, Italy
    Free Radic Biol Med 28:13-7. 2000
    We measured 8-hydroxy-2-deoxyguanosine (8-OHdG) levels in human leukocytes from healthy donors to evaluate oxidative DNA damage and its correlation with smoking, physical exercise, and alcohol consumption...
  69. pmc Ig-like transcript 7, but not bone marrow stromal cell antigen 2 (also known as HM1.24, tetherin, or CD317), modulates plasmacytoid dendritic cell function in primary human blood leukocytes
    Barbara Tavano
    Division of Infectious Diseases, Immunology Section, Chelsea and Westminster Hospital, Department of Medicine, Faculty of Medicine, Imperial College, London SW10 9NH, United Kingdom
    J Immunol 190:2622-30. 2013
    ..IFN-γ, IL-4, IL-10, and TNF-α had only marginal effects on BST2 expression in blood leukocytes compared with TLR9L...
  70. doi Fetal membranes exhibit selective leukocyte chemotaxic activity during human labor
    N Gomez-Lopez
    Research Direction, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Montes Urales 800, Lomas de Virreyes, Mexico City, Mexico
    J Reprod Immunol 80:122-31. 2009
    ..The number and phenotype of attracted leukocytes were analyzed by flow cytometry...
  71. pmc Enterovirus 71 binding to PSGL-1 on leukocytes: VP1-145 acts as a molecular switch to control receptor interaction
    Yorihiro Nishimura
    Department of Virology II, National Institute of Infectious Diseases, Musashimurayama shi, Tokyo, Japan
    PLoS Pathog 9:e1003511. 2013
    Some strains of enterovirus 71 (EV71), but not others, infect leukocytes by binding to a specific receptor molecule: the P-selectin glycoprotein ligand-1 (PSGL-1)...
  72. ncbi Oxidative stress-related alteration of the copy number of mitochondrial DNA in human leukocytes
    Chin San Liu
    Department of Neurology and Vascular and Genomic Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
    Free Radic Res 37:1307-17. 2003
    The role of oxidative stress in the regulation of the copy number of mitochondrial DNA (mtDNA) in human leukocytes is unclear...
  73. pmc Healthy lifestyle and leukocyte telomere length in U.S. women
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 7:e38374. 2012
    ..Whether a healthy lifestyle may be associated with longer telomere length is largely unknown...
  74. pmc Physical fitness and telomere length in patients with coronary heart disease: findings from the Heart and Soul Study
    Jeffrey Krauss
    School of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e26983. 2011
    ..Short telomere length (TL) is an independent predictor of mortality in patients with coronary heart disease (CHD). However, the relationship between physical fitness and TL has not been explored in these patients...
  75. ncbi Chemokines and chemokine receptors: their manifold roles in homeostasis and disease
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Cell Mol Immunol 1:95-104. 2004
    ..Therefore, chemokines and their receptors are important targets for modulation of host responses in pathophysiological conditions and for therapeutic intervention of human diseases...
  76. pmc Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms
    Olga Barreiro
    Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, 28006 Madrid, Spain
    J Cell Biol 183:527-42. 2008
    ....
  77. doi Association between mitochondrial DNA content in leukocytes and colorectal cancer risk: a case-control analysis
    Falin Qu
    Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Cancer 117:3148-55. 2011
    ..This study was undertaken to investigate whether mtDNA content in peripheral blood lymphocytes (PBLs) could be used as a risk predictor for colorectal cancer (CRC)...
  78. ncbi Expression cloning of a functional glycoprotein ligand for P-selectin
    D Sako
    Genetics Institute, Small Molecule Drug Discovery Group, Cambridge, Massachusetts 02140
    Cell 75:1179-86. 1993
    The initial adhesive interactions between circulating leukocytes and endothelia are mediated, in part, by P-selectin. We now report the expression cloning of a functional ligand for P-selectin from an HL-60 cDNA library...
  79. pmc Genetics of leukocyte telomere length and its role in atherosclerosis
    Abraham Aviv
    The Center for Human Development and Aging, University of Medicine and Dentistry, New Jersey Medical School, Newark, NJ 07103, USA
    Mutat Res 730:68-74. 2012
    ..The mechanisms underlying these associations are still not well understood, but they stem in part from genetic factors in control of telomere maintenance and the rate of HSC replication...
  80. doi Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy
    Michela Zattoni
    Institute of Pharmacology and Toxicology and Institute of Molecular Cancer Research, University of Zurich, CH 8057 Zurich, Switzerland
    J Neurosci 31:4037-50. 2011
    ..CD45 (common leukocyte antigen) and CD3 (T-lymphocytes), we show here microglial activation and infiltration of leukocytes in sclerotic tissue from patients with mesial temporal lobe epilepsy (TLE), as well as in a model of TLE (..
  81. ncbi VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site
    M J Elices
    Division of Tumor Virology, Dana Farber Cancer Institute, Boston, Massachusetts 02115
    Cell 60:577-84. 1990
    ..The VCAM-1/VLA-4 ligand-receptor pair may play a major role in the recruitment of mononuclear leukocytes to inflammatory sites in vivo.
  82. doi Educational attainment but not measures of current socioeconomic circumstances are associated with leukocyte telomere length in healthy older men and women
    Andrew Steptoe
    Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
    Brain Behav Immun 25:1292-8. 2011
    ..Education may also promote problem-solving skills leading to reduced biological stress responsivity, with favorable consequences for biological aging...
  83. pmc Altered DNA methylation in leukocytes with trisomy 21
    Kristi Kerkel
    Institute for Cancer Genetics, Columbia University Medical Center, New York, NY, USA
    PLoS Genet 6:e1001212. 2010
    ..We profiled DNA methylation in total peripheral blood leukocytes (PBL) and T-lymphocytes from adults with DS and normal controls and found gene-specific abnormalities of CpG ..
  84. pmc Tryptophan/kynurenine metabolism in human leukocytes is independent of superoxide and is fully maintained in chronic granulomatous disease
    Suk See De Ravin
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 116:1755-60. 2010
    ..normal levels of kynurenine in cultures of O(2)(·)-deficient monocytes, dendritic cells, and polymorphonuclear leukocytes from gp91(PHOX)- or p47(PHOX)-deficient human CGD donors...
  85. pmc Adipose tissue recruitment of leukocytes
    Emily K Anderson
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0615, USA
    Curr Opin Lipidol 21:172-7. 2010
    ..Due to the continuing rise in obesity around the world, understanding how these ATMs contribute to metabolic disorders is of much interest...
  86. ncbi Biomaterial-associated thrombosis: roles of coagulation factors, complement, platelets and leukocytes
    Maud B Gorbet
    Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, University of Toronto, 4 Taddle Creek Road, Room 407D, Toronto, Ont, Canada M5S 3G9
    Biomaterials 25:5681-703. 2004
    ..considered in the context of biomaterial-associated thrombosis the other major players in blood: complement and leukocytes. Biomaterials are known agonists of complement and leukocyte activation, but this is frequently studied only in ..
  87. pmc Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis
    Lubor Borsig
    Glycobiology Research and Training Center and the Cancer Center, Department of Medicine and Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093 0687, USA
    Proc Natl Acad Sci U S A 99:2193-8. 2002
    ..Surprisingly, L-selectin expressed on endogenous leukocytes also facilitates metastasis in both the syngeneic and xenogeneic (T and B lymphocyte deficient) systems...
  88. pmc HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells
    Christopher Schuster
    Department of Dermatology, DIAID, 1090 Vienna, Austria
    J Exp Med 206:169-81. 2009
    Adequate numbers and functional maturity are needed for leukocytes to exhibit a protective role in host defense...
  89. pmc Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease
    Laurent Savale
    Assistance Publique Hopitaux de Paris, Hopital Henri Mondor, Service de Physiologie Explorations Fonctionnelles, Universite Paris 12, 94010 Creteil, France
    Am J Respir Crit Care Med 179:566-71. 2009
    ..Telomere length is considered a marker for biological aging. Chronic obstructive pulmonary disease (COPD) may be associated with premature aging...
  90. pmc Leukocytes infiltrate the skin and draining lymph nodes in response to the protozoan Leishmania infantum chagasi
    Colin J Thalhofer
    Interdisciplinary Immunology Program, University of Iowa, Iowa City, IA 52242, USA
    Infect Immun 79:108-17. 2011
    ..luciferase-positive) promastigotes during the first 24 h after inoculation yet decreased the numbers of leukocytes containing intracellular (mCherry-positive) parasites. From 3 days onward, total L...
  91. doi Genomic expression profiling of peripheral blood leukocytes of pigs infected with highly virulent classical swine fever virus strain Shimen
    Zixue Shi
    Institute of Veterinary Sciences, Academy of Military Medical Sciences, 1068 Qinglong Road, Changchun 130062, PR China
    J Gen Virol 90:1670-80. 2009
    ..cells, microarray analyses were performed to detect alterations in genomic expression of pig peripheral blood leukocytes (PBLs) following CSFV infection...
  92. pmc DNA methylation in white blood cells: association with risk factors in epidemiologic studies
    Mary Beth Terry
    Department of Epidemiology, Columbia University Medical Center, Mailman School of Public Health, New York, NY, USA
    Epigenetics 6:828-37. 2011
    ..Large, prospective studies will be needed to understand whether changes in risk factors are associated with changes in DNA methylation patterns, and if changes in DNA methylation patterns are associated with changes in disease endpoints...
  93. pmc Association between global DNA hypomethylation in leukocytes and risk of breast cancer
    Ji Yeob Choi
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Carcinogenesis 30:1889-97. 2009
    ..Global DNA hypomethylation may result in chromosomal instability and oncogene activation, and as a surrogate of systemic methylation activity, may be associated with breast cancer risk...
  94. doi Transgenic zebrafish reporter lines reveal conserved Toll-like receptor signaling potential in embryonic myeloid leukocytes and adult immune cell lineages
    Chris Hall
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Auckland, New Zealand
    J Leukoc Biol 85:751-65. 2009
    ..fluorescently marked cells/tissues consistent with endogenous myd88 expression, including a subset of myeloid leukocytes. These innate immune cells were confirmed to express other TLR adaptors including Mal, trif, and Sarm...
  95. pmc Obesity related methylation changes in DNA of peripheral blood leukocytes
    Xiaoling Wang
    Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA, USA
    BMC Med 8:87. 2010
    ..Because of emerging evidence that immune responses are epigenetically regulated, we hypothesized that DNA methylation changes are involved in obesity induced immune dysfunction and aimed to identify these changes...
  96. pmc Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease
    Ramin Farzaneh-Far
    Division of Cardiology, Room 5G1, San Francisco General Hospital, 1001 Potrero Ave, San Francisco, CA 94110, USA
    JAMA 303:250-7. 2010
    ..Increased dietary intake of marine omega-3 fatty acids is associated with prolonged survival in patients with coronary heart disease. However, the mechanisms underlying this protective effect are poorly understood...
  97. ncbi Effects of trophoblast invasion on the distribution of leukocytes in uterine and tubal implantation sites
    U von Rango
    Department of Anatomy and Reproductive Biology, School of Medicine, RWTH University of Aachen, Aachen, Germany
    Fertil Steril 76:116-24. 2001
    ..To distinguish endocrine and paracrine influences on leukocyte subpopulations at uterine and tubal implantation sites...
  98. pmc A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them
    Christopher V Carman
    The CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 167:377-88. 2004
    ..vascular cell adhesion molecule-1-enriched vertical microvilli-like projections that surrounded transmigrating leukocytes and drove redistribution of their integrins into linear tracks oriented parallel to the direction of diapedesis...
  99. doi Association of leukocyte telomere length with type 2 diabetes in mainland Chinese populations
    Qin Shen
    Institutes of Biomedical Sciences, Fudan University, Shanghai, 303 Mingdao Building, 138 Yixueyuan Road, Shanghai 200032, People s Republic of China
    J Clin Endocrinol Metab 97:1371-4. 2012
    ..This is implicated in the development of type 2 diabetes (T2D). For this reason, we hypothesize that telomere shortening can characterize T2D...
  100. doi Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs
    Konstantin Stark
    Medizinische Klinik und Poliklinik I, Klinikum der Universitat, Ludwig Maximilians Universität and Deutsches Herzzentrum München, Technische Universitat Munchen, Munich, Germany
    Nat Immunol 14:41-51. 2013
    ..Here we demonstrate that NG2(+) pericytes controlled the pattern and efficacy of the interstitial migration of leukocytes in vivo...
  101. doi Cancer dissemination--lessons from leukocytes
    Chris D Madsen
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Dev Cell 19:13-26. 2010
    ..However, it is also becoming apparent that some cancer cells move in an amoeboid way similar to leukocytes. This theme will be the focus of the review, where we will discuss the similarities and differences between the ..

Research Grants76

  1. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
    ..asthma is characterized by airway hyperreactivity (AHR), inflammatory infiltrates containing eosinophilic leukocytes, lymphocytes, and mast cells, increased mucus secretion, and elevated serum IgE levels...
  2. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ..1 mutant against oxidative stress challenge in vitro, or against phagocytosis by human leukocytes, will assess the contribution of PolA...
  3. Mitochondrial dysfunction, oxidative stress, and surgical acute kidney injury
    FREDERIC TREMAINE BILLINGS; Fiscal Year: 2013
    ..unreadable] coactivator 1-[unreadable] (PGC-1[unreadable]) RNA expression, and mtDNA copy number from isolated leukocytes and arterial lactate:pyruvate ratios), and clinical AKI (defined using AKIN staging consensus criteria for AKI ..
  4. Prevention of UV-induced carcinogenesis by cyanidin-3-glucoside
    Xianglin Shi; Fiscal Year: 2013
    ..These inflammatory mediators include infiltrating leukocytes and myeloperoxidase (MPO), COX-2, PGE2, and several pro-inflammatory cytokines, TNF-1, IL-2, and IL-6...
  5. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    ..DVs infect peripheral human leukocytes, dendritic cells and endothelial cells, and mechanisms by which DVs enhance vascular permeability are just ..
  6. The Neuroimmunology of Viral Infection
    DANIEL J CARR; Fiscal Year: 2013
    ..There are also notable changes in recruitment of leukocytes residing in the nervous system post infection of CD118-/- mice...
  7. PATHOPHYSIOLOGY OF THE ENDOTHELIUM
    Francis W Luscinskas; Fiscal Year: 2013
    ..CD47 dependent regulation of VLA-4 and LFA-1 integrin adhesion, in the recruitment of inflammatory mononuclear leukocytes into sites of chronic inflammation...
  8. Lipid Droplet Metabolism
    Fredric B Kraemer; Fiscal Year: 2013
    ..in many, if not most, tissues and cells, including liver, skeletal muscle, cardiac muscle, enterocytes, and leukocytes, under certain physiological and pathophysiological conditions where the LDs generally serve as an energy ..
  9. Signaling by Cytoplasmic Tyrosine Kinases in Leukocytes
    Clifford A Lowell; Fiscal Year: 2013
    ..play pivotal roles in initiating intracellular signaling from a diverse repertoire of receptors on innate immune leukocytes. The Src-family kinases initiate intracellular signaling from these receptors by phosphorylating specific ..
  10. Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
    Alexandra L Howell; Fiscal Year: 2013
    ..RNA interference (RNAi) with short-interfering RNA (siRNA) to silence expression of CCR5 and DC-SIGN on mucosal leukocytes from the female reproductive and gastrointestinal tracts using an immunodeficient mouse model that is ..
  11. Monocyte activation and the role of CD11c in obesity-linked metabolic syndrome
    Huaizhu Wu; Fiscal Year: 2013
    ..Current data suggest that these changes activate leukocytes in blood and AT...
  12. Redox regulation of phagocyte NOX2 in inflammation and aging
    Robert A Clark; Fiscal Year: 2013
    ..Aim 3 is to examine the status and role of H2O2-NOX2 regulation in human phagocytic leukocytes as a function of age, including both cross-sectional and longitudinal assessment of NOX2-mediated superoxide ..
  13. Mindfulness Based Stress Reduction as an Adjunctive Treatment for Psoriasis
    Jan A Moynihan; Fiscal Year: 2013
    ..weight messenger proteins) produced by T helper (Th)1 and Th17 lymphocytes, antigen presenting cells, and leukocytes have been implicated as being critical to the development of lesions...
  14. Role of Stat3 in Breast Cancer Tumorigenesis
    Jacqueline F Bromberg; Fiscal Year: 2010
    ..expression of Stat3C in the virgin gland mediates production of pro-inflammatory cytokines and recruitment of leukocytes. We hypothesize that in breast cancer, sustained activation of epithelial cell Stat3, will trigger chronic ..
  15. Mechanisms of Neutrophil-induced Liver Toxicity
    HARTMUT W JAESCHKE; Fiscal Year: 2012
    ..However, these leukocytes also fulfill a vital host defense function against invading microorganisms...
  16. PLD2, as a GEF or as a Lipase, is Central to Leukocyte Chemotaxis
    JULIAN G CAMBRONERO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Blood leukocytes migrate towards the sites of inflammation (a beneficial effect) or towards compromised tissues after an ischemic attack (a deleterious effect), such as in the case of ischemia/..
  17. Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
    LAURA ELISE CROTTY ALEXANDER; Fiscal Year: 2013
    ..I will explore how genetic manipulation of HIF-11 levels in leukocytes influences asthma susceptibility, and examine whether a therapeutic strategy to pharmacologically inhibit HIF-11 ..
  18. Characterization of IL36, a novel cytokine
    Albert Zlotnik; Fiscal Year: 2012
    ..CD4 T cells also produce it upon activation with anti CD3. Besides leukocytes, IL36 is also expressed in mucosal tissues, and in the skin, suggesting that epithelial cells also express it...
  19. MUCOSAL DEFENSE MECHANISMS IN SUBSTANCE ABUSE
    David R Brown; Fiscal Year: 2010
    ..morphological interrelationships between opioid receptors and opioid peptides in epithelial cells, neurons and leukocytes of Peyer's patch and absorptive mucosae by immunocytochemical and in situ hybridization methods...
  20. Dietary Scavenging of Reactive Species in Lung Injury: Role of Macrophages
    THEA NOREEN GOLDEN; Fiscal Year: 2013
    ..NO production is increased via upregulation of inducible nitric oxide synthase (iNOS) expression in leukocytes and epithelial cells...
  21. Genome-wide DNA Methylation Profiles Associated with Abnormal Intrauterine Growth
    Cristina Montagna; Fiscal Year: 2013
    ..relevant loci for evaluation of functional significance and comparison in other cell types (lymphocytes and leukocytes from umbilical cord and maternal peripheral blood and umbilical vein endothelial cells)...
  22. Human Decidual Leukocytes and Their Placental Ligands
    JACK STROMINGER; Fiscal Year: 2009
    ..Multiple mechanisms contribute to implantation tolerance. Maternal leukocytes that populate the uterine decidua certainly play an important role...
  23. A XENOPUS LAEVIS RESEARCH RESOURCE FOR IMMUNOBIOLOGY
    Jacques Robert; Fiscal Year: 2013
    ..g., thymus, spleen) or leukocytes;by developing in vivo knockdown by RNA interference using transgenesis to reveal the function of immunologically-..
  24. Telomere and its bio-regulators as predictors for clinical diabetes in women
    Simin Liu; Fiscal Year: 2010
    ..small clinical studies have associated systemic inflammation with accelerated telomere erosion in human leukocytes. Our recent epidemiological work involving several large and well-characterized cohorts of men and women has ..
  25. TNF-Mediated Tumor Promotion: The Role of Vascular Leukocytes
    Pampee P Young; Fiscal Year: 2011
    ..Recently, we and others have characterized a significant population of tumor- associated leukocytes which co-express endothelial and myeloid markers, the so called "vascular leukocytes"...
  26. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
    ..Upon signaling by chemokines such as MCP1 leukocytes are drawn toward endothelial cells...
  27. Group B. Streptococci and Toll-like Receptors
    Douglas T Golenbock; Fiscal Year: 2012
    ..The disease is caused by streptococcal molecules activating primitive receptors on leukocytes to over produce inflammatory mediators...
  28. Role of Inflammation in the Pathobiology of Abdominal Aortic Aneurysm
    KATHLEEN RAMAN; Fiscal Year: 2013
    ..RAGE null mice with RAGE-sufficient bone marrow to determine whether the presence of RAGE on bone marrow derived leukocytes is sufficient to polarize macrophages into an M1 subtype in the aorta of elastase-perfused mice...
  29. Targeting Siglec-8/-F to treat eosinophil and mast cell related disorders
    Bruce S Bochner; Fiscal Year: 2013
    ..Siglecs (sialic acid-binding, immunoglobulin-like lectins) are cell surface proteins found predominantly on leukocytes. Siglec-8 was discovered by us about a decade ago and is selectively expressed on eosinophils and mast cells...
  30. Targeting Siglec-8/-F to treat eosinophil and mast cell related disorders
    Bruce S Bochner; Fiscal Year: 2012
    ..Siglecs (sialic acid-binding, immunoglobulin-like lectins) are cell surface proteins found predominantly on leukocytes. Siglec-8 was discovered by us about a decade ago and is selectively expressed on eosinophils and mast cells...
  31. Race-based social stress and health trajectories from adolescence to adulthood
    Jacquelynne S Eccles; Fiscal Year: 2010
    ..and immune cell resistance to the anti-inflammatory effects of glucocorticoids, gene expression profiling of leukocytes to identify broad groups of genes associated with social stress (e.g...
  32. Rho-Modifying Cytotoxic Necrotizing Factor of E. coli
    ALISON DAVIS O'BRIEN; Fiscal Year: 2013
    ..UPEC strain CP9 survives better than does its cnf1 isogenic mutant in human and mouse polymorphonuclear leukocytes (PMNs)...
  33. COCHLEAR MACROPHAGES AND EPITHELIAL REPAIR
    Keiko Hirose; Fiscal Year: 2013
    ..We will also use radiation bone marrow chimeras to isolate the effects of CD36 expression on leukocytes versus cochlear supporting cells...
  34. Dysregulation of the inflammatory response by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2013
    ..Accumulation of neutrophils (polymorphonuclear leukocytes, PMNs) in the lungs is essential for development of severe disease in animals infected with this pathogen, and ..
  35. Role of lipoxygenase pathway in early microvascular dysfunction during diabetic r
    MOHAMED AL SAYED AL-SHABRAWEY; Fiscal Year: 2013
    ..inflammation we will utilize bone marrow transplantation (BMT) studies to determine the effect of wild type leukocytes with 12/15-LOX knockout retinal endothelial cells, and vise versa, on inflammatory cell infiltration and ..
  36. Galectin-3 in regulation of allergic skin inflammation
    Fu Tong Liu; Fiscal Year: 2013
    ..It is expressed by a number of cell types, including epithelial cells and various leukocytes. A number of extracellular functions have been demonstrated by using exogenously added galectin-3 and these are ..
  37. Pathogenesis of Subtype IE Venezuelan Equine Encephalitis Virus
    ALISON PAIGE ADAMS; Fiscal Year: 2012
    ..Equine peripheral blood leukocytes (PBLs) will also be examined for viral replication in vivo during early infection...
  38. Novel mechanisms of niacin to improve HDL function: Role of myeloperoxidase
    Moti L Kashyap; Fiscal Year: 2013
    ..in this application we propose the novel concept that niacin, by inhibiting MPO secretion from circulating leukocytes, inhibits MPO-mediated generation of "dysfunctional HDL" in blood resulting in improvements in cholesterol ..
  39. Astrocytes Play a Critical Role in the Pathology of EAE
    JOHN ROLAND BETHEA; Fiscal Year: 2013
    ..studies in Aim 2 will determine if there are differences in blood brain permeability and infiltration of leukocytes in the CNS of diseased WT and mutant mice...
  40. Bordetella Cyclase Toxin:Effect on Leukocytes and Respiratory Epithelial Cells
    Erik L Hewlett; Fiscal Year: 2013
    ....
  41. Role of Neutrophil-Platelet Interactions in Vascular Occlusive Disorders
    Nauder Faraday; Fiscal Year: 2010
    ..The purpose of the proposed studies is to identify a key point in the communication between leukocytes and platelets that can serve as a target for novel pharmaceuticals that will prevent vascular occlusion despite ..
  42. MOLECULAR MODELS OF IMMUNE-MEDIATED VASCULAR INJURY
    Jeffrey R Bender; Fiscal Year: 2012
    ..interactions influence vascularized organ allografts at multiple levels, including trafficking of host leukocytes into the graft, costimulation of alloreactive T cells through leukocyte integrins, or directed killing of donor ..
  43. Pososome Regulated Monocyte/Macrophage Tissue Infiltration
    Dianne Cox; Fiscal Year: 2013
    ..proposed that podosomes, F-actin rich ventral adhesion and protrusive structures, are employed by a range of leukocytes including MDs to not only mediate matrix degradation but to also play a role in MD chemotaxis and tissue ..
  44. ClC-3 ion transport modulates NADPH oxidase-dependent PMN priming by endotoxin
    Jessica G Moreland; Fiscal Year: 2012
    ..Polymorphonuclear leukocytes (PMNs) are critical cellular elements of the innate immune response, but are also responsible for host tissue ..
  45. Pregnancy, Pre-eclampsia, Anti-oxidants and Endothelial Cell Function
    Gautam Chaudhuri; Fiscal Year: 2010
    ..is evidence in the literature that tumor necrosis factor a (TNFa) may be released by the placenta and activated leukocytes leading to activation of endothelial cells...
  46. microRNA analysis of neurons generated from patient-specific iPSCs
    Herbert M Lachman; Fiscal Year: 2013
    ..Investigators have had to resort to autopsy specimens and peripheral blood leukocytes to carry out such studies...
  47. Regulation of Endothelial ICAM-1 and PMN-Mediated Lung Injury by Actin Dynamics
    Fabeha Fazal; Fiscal Year: 2013
    ..ICAM-1;CD54) in endothelial cells, and how this event promotes sequestration and migration of polymorphonuclear leukocytes (PMN) in the lung and thus contributes to development of lung vascular injury...
  48. Epigenetics of the Aging Astrocyte: Implications for Stroke
    Farida Sohrabji; Fiscal Year: 2013
    ..glutamate, decreased growth factor release, increased release of chemokines and increased ability to recruit leukocytes. These changes are consistent with increased infarct volume observed in older females...
  49. BLOOD PRESSURE REGULATION, STRESS AND MATERNAL OXYTOCIN RESPONSE
    Kathleen C Light; Fiscal Year: 2010
    ..low financial stress. This research will be the first to examine OT gene expression on human leukocytes, and the first to examine the influence of life stress on OT, SNS and HPA gene expression markers together...
  50. Chemokine Signals in the Premetastatic Niche Inhibit Metastasis
    Ann Richmond; Fiscal Year: 2013
    ..Chemokines are important for the recruitment of leukocytes to the tumor microenvironment (TME) which can affect invasion and metastasis...
  51. Histone modifications and respiratory effects of traffic particle exposure
    Lifang Hou; Fiscal Year: 2013
    ..e., H3K4 dimethylation and H3K9 acetylation, in blood leukocytes from a highly PM- exposed population...
  52. Regulating the Immune Microenvironment in Breast Cancer
    Lisa Marie Coussens; Fiscal Year: 2013
    ..to underlying inflammation or infection, it exhibits tumor-associated inflammation marked by infiltration of leukocytes into developing tumors where increases in some immune cell subsets in neoplastic stroma parallels disease ..
  53. MECHANISM OF PATHOGENIC ACTIVITY OF PEPTIDOGLYCAN
    Roman Dziarski; Fiscal Year: 2012
    ..membranes in the oral cavity and gastrointestinal tract, and in sweat, sebum, saliva, and polymorphonuclear leukocytes. The goal of this project is to determine the in vivo role ofmammalian PGLYRPs, and specifically, based on in ..
  54. Human Decidual Leukocytes and Their Placental Ligands
    Jack L Strominger; Fiscal Year: 2013
    ..Maternal leukocytes that populate the uterine decidua certainly play an important role in tolerance...
  55. Abdominal Adipose Tissue Inflammation
    Peter S Tobias; Fiscal Year: 2013
    ..tissue segments and in multiple cells within adipose tissues including adipocytes, macrophages, dendritic cells, leukocytes, endothelial cells and fibroblasts...
  56. LEUKOTRIENES AND DIABETIC RETINOPATHY
    Rose A Gubitosi-Klug; Fiscal Year: 2013
    ..three mechanisms by which leukotrienes may regulate chronic inflammation in the diabetic retina: 1) autocrine: leukocytes may generate increased superoxide and leukotriene B4 through autoamplification, 2) paracrine: leukocytes may ..
  57. Adhesion Mechanisms Mediating Sickle Cell Vasooclusion In Vivo
    Paul S Frenette; Fiscal Year: 2013
    ..found using intravital microcopy imaging in a humanized mouse model of sickle cell disease (SCD) that adherent leukocytes recruited in inflamed venules, played a direct role in VOC by interacting with circulating erythrocytes (RBC)...
  58. Functional Analysis of PAAN-AG5, the Baboon Counterpart of HLA-G5
    Daudi K Langat; Fiscal Year: 2010
    ..whether recombinant Paan-AG5 acts similarly on sub- sets of immune cells purified from baboon peripheral blood leukocytes. The specific aims of this proposal are to (i) generate and characterize recombinant Paan-AG5 protein, and (ii) ..
  59. Sulfotransferases in the Synthesis of L-Selectin Ligands
    Steven D Rosen; Fiscal Year: 2010
    ..Our experiments suggest that extravasated leukocytes in the airways can utilize L-selectin to react with sulfated mucin ligands, which are expressed in inflamed ..
  60. Development of Vaccine Strategies to prevent EBV+ Lymphoma in Patients with HIV
    ROBERT ALAN BAIOCCHI; Fiscal Year: 2010
    ..We utilized a SCID mouse model which, when engrafted with human leukocytes from healthy EBV seropositive donors, spontaneously develops human EBV-LPD...
  61. T Cells, Macrophages, Chemokines, and Adiposopathy in Diet-Induced Obesity
    CHRISTIE MITCHELL BALLANTYNE; Fiscal Year: 2013
    ..These recruited and activated leukocytes cause pathological adipose tissue dysfunctions (adiposopathy), leading to metabolic abnormalities...
  62. Translational studies of the Platelet Specific Receptor Trem Like Transcript (TLT
    A Valance Washington; Fiscal Year: 2013
    ..P-selectin initiate's primary contact between platelets and leukocytes and/or endothelial cells and consequently, several clinical trials have been targeted at controlling ..
  63. Peripheral Biomarkers in Familial Alzheimer's Disease
    Paul Coleman; Fiscal Year: 2009
    ..to inflammatory response and to cellular stress can distinguish Alzheimer's disease peripheral blood leukocytes from control leukocytes...
  64. Innate immune suppression following experimental injury
    KRISTIN C GREATHOUSE; Fiscal Year: 2012
    ..Early experimental evidence indicates there is a reduced ability leukocytes from whole blood, when stimulated by LPS ex vivo, to produce the pro-inflammatory cytokine tumor necrosis factor ..
  65. HTS assay development for inhibitors of sickle cell
    PAUL FRENETTE; Fiscal Year: 2006
    ..provided by applicant): The selectin family of adhesion molecules plays key role in the rolling and adhesion of leukocytes in systemic venules...
  66. PREVENTION OF ORGAN INJURY DURING CARDIOPULMONARY BYPASS
    DUKE CAMERON; Fiscal Year: 1993
    The objective of this project is to examine the roles of complement and leukocytes in the pathogenesis of "post-perfusion syndome" (PPS) after cardiopulmonary bypass (CPB) and to determine if inhibition of complement activation and ..
  67. 41st Annual Meeting of the Society for Leukocyte Biology
    Jill Suttles; Fiscal Year: 2009
    Conference Plan The 41st Annual Meeting of the Society for Leukocyte Biology. "Leukocytes: Tissue Interactions, Homeostasis and Host Defense". Organizers: Jill Suttles, Ph.D., University of Louisville School of Medicine David W.H...
  68. C3A ACTIVATION OF LEUKOCYTES IN INFLAMMATION
    TONY HUGLI; Fiscal Year: 2002
    DESCRIPTION (Adapted from Investigator's abstract): Infiltration of leukocytes is a characteristic of both acute and chronic inflammatory diseases...
  69. Ras and Chemokine Stimulated Neutrophil Polarization
    Cindy Knall; Fiscal Year: 2004
    Polymorphonuclear leukocytes, neutrophils, are the most abundant leukocytes in peripheral blood. They play a major role in innate immunity and may contribute to the development of the adaptive immune response...
  70. Matrix Metalloproteinases and Spinal Cord Injury
    Linda J Noble; Fiscal Year: 2010
    ..Aim 1 will test the hypothesis that infiltrating leukocytes mediate MMP-9 dependent PTHN...
  71. METABOLIC ACTIVATION OF ARYLAMINES IN LEUKOCYTES
    Michael Corbett; Fiscal Year: 1991
    The objective of this research program is to elucidate the processes by which leukocytes cause the bioactivation or toxification of arylamines and related chemicals...
  72. Eosinophil Lipid Bodies in Allergic Inflammation
    Peter Weller; Fiscal Year: 2004
    ..Eosinophils and other leukocytes associated in vivo with inflammatory reactions: l) exhibit, as yet poorly understood, "priming" responses, by ..
  73. CHARACTERIZATION OF PLATELET:LEUKOCYTE INTERACTIONS
    THOMAS DIACOVO; Fiscal Year: 2000
    ..made in the primary sponsor's laboratory characterizing ICAM-2 on platelets and its interaction with LFA-1 on leukocytes. Based on this study, we hypothesize that sequential adhesion events responsible for mediating leukocyte:..
  74. GTP-BINDING PROTEIN RHO IN T CELL SIGNALING PATHWAYS
    Jonathan Moorman; Fiscal Year: 2000
    ..and the basic processes that govern immune responses led me to the study of signal transduction pathways in leukocytes. Over the last several years...
  75. Biomechanics of Leukocytes and Molecular Imaging Agents
    MICHAEL BRANDEAU LAWRENCE; Fiscal Year: 2010
    ..We studied the cellular biomechanics of leukocytes as they become adherent in flow chamber systems and in postcapillary venules in vivo...
  76. TRANSEPITHELIAL MIGRATION OF HUMAN NEUTROPHILS
    Eva Cramer; Fiscal Year: 1991
    ..However, very little is known about how these leukocytes are attracted to sites of viral infection, how they recognize virus-infected cells, the effect they have on the ..