erythrocyte membrane

Summary

Summary: The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.

Top Publications

  1. ncbi Increased erythrocyte phosphatidylserine exposure in sickle cell disease: flow-cytometric measurement and clinical associations
    B L Wood
    Department of Laboratory Medicine, University of Washington, Seattle 98195 7110, USA
    Blood 88:1873-80. 1996
  2. doi Validation of an FFQ to estimate the intake of fatty acids using erythrocyte membrane fatty acids and multiple 3d dietary records
    Bo Zhang
    Faculty of Nutrition, School of Public Health, Sun Yat Sen University, Guangzhou, China
    Public Health Nutr 13:1546-52. 2010
  3. pmc Carmustine-induced phosphatidylserine translocation in the erythrocyte membrane
    Kashif Jilani
    Department of Physiology, University of Tuebingen, Gmelinstr 5, Tuebingen D 72076, Germany
    Toxins (Basel) 5:703-16. 2013
  4. pmc Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform
    Che Ming J Hu
    Department of Nanoengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 108:10980-5. 2011
  5. ncbi P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1
    J A Rowe
    Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA
    Nature 388:292-5. 1997
  6. ncbi Altered erythrocyte endothelial adherence and membrane phospholipid asymmetry in hereditary hydrocytosis
    Patrick G Gallagher
    Department of Pediatrics, Yale University School of Medicine, PO Box 208064, 333 Cedar St, New Haven, CT 06520 8064
    Blood 101:4625-7. 2003
  7. ncbi Lysophosphatidic acid induces thrombogenic activity through phosphatidylserine exposure and procoagulant microvesicle generation in human erythrocytes
    Seung Min Chung
    College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    Arterioscler Thromb Vasc Biol 27:414-21. 2007
  8. pmc Red cell membrane: past, present, and future
    Narla Mohandas
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY, USA
    Blood 112:3939-48. 2008
  9. doi Sequential, ordered acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 domains
    Gerald K K Cham
    Centre for Medical Parasitology at Department of International Health, Immunology, and Microbiology, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark
    J Immunol 183:3356-63. 2009
  10. ncbi A band 3-based macrocomplex of integral and peripheral proteins in the RBC membrane
    Lesley J Bruce
    Department of Biochemistry, University of Bristol, United Kingom
    Blood 101:4180-8. 2003

Detail Information

Publications352 found, 100 shown here

  1. ncbi Increased erythrocyte phosphatidylserine exposure in sickle cell disease: flow-cytometric measurement and clinical associations
    B L Wood
    Department of Laboratory Medicine, University of Washington, Seattle 98195 7110, USA
    Blood 88:1873-80. 1996
    ..We developed a flow-cytometric assay to measure exposure of PS on the outer face of the erythrocyte membrane based on addition of fluorescein-annexin V to whole-blood specimens...
  2. doi Validation of an FFQ to estimate the intake of fatty acids using erythrocyte membrane fatty acids and multiple 3d dietary records
    Bo Zhang
    Faculty of Nutrition, School of Public Health, Sun Yat Sen University, Guangzhou, China
    Public Health Nutr 13:1546-52. 2010
    ..The objective of our study is to evaluate the validity of an FFQ used to assess dietary fatty acid intake among middle-aged Chinese adults in Southern China...
  3. pmc Carmustine-induced phosphatidylserine translocation in the erythrocyte membrane
    Kashif Jilani
    Department of Physiology, University of Tuebingen, Gmelinstr 5, Tuebingen D 72076, Germany
    Toxins (Basel) 5:703-16. 2013
    ..The effect on annexin V binding was significantly blunted in the absence of extracellular Ca²⁺. In conclusion, carmustine stimulates eryptosis at least partially by increasing cytosolic Ca²⁺ activity...
  4. pmc Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform
    Che Ming J Hu
    Department of Nanoengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 108:10980-5. 2011
    ..The structure, size and surface zeta potential, and protein contents of the erythrocyte membrane-coated nanoparticles were verified using transmission electron microscopy, dynamic light scattering, and ..
  5. ncbi P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1
    J A Rowe
    Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA
    Nature 388:292-5. 1997
    ..also bind to endothelial cells, and this interaction is mediated by the parasite-derived variant erythrocyte membrane protein PfEMP1, which is encoded by the var gene family...
  6. ncbi Altered erythrocyte endothelial adherence and membrane phospholipid asymmetry in hereditary hydrocytosis
    Patrick G Gallagher
    Department of Pediatrics, Yale University School of Medicine, PO Box 208064, 333 Cedar St, New Haven, CT 06520 8064
    Blood 101:4625-7. 2003
    ..Increased phosphatidylserine exposure accelerating thrombin-forming processes has been proposed as a mechanism for thrombosis in sickle cell disease and beta-thalassemia and may play a similar role in hereditary hydrocytosis...
  7. ncbi Lysophosphatidic acid induces thrombogenic activity through phosphatidylserine exposure and procoagulant microvesicle generation in human erythrocytes
    Seung Min Chung
    College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    Arterioscler Thromb Vasc Biol 27:414-21. 2007
    ....
  8. pmc Red cell membrane: past, present, and future
    Narla Mohandas
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY, USA
    Blood 112:3939-48. 2008
    ....
  9. doi Sequential, ordered acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 domains
    Gerald K K Cham
    Centre for Medical Parasitology at Department of International Health, Immunology, and Microbiology, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark
    J Immunol 183:3356-63. 2009
    ..The binding is mediated by members of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family...
  10. ncbi A band 3-based macrocomplex of integral and peripheral proteins in the RBC membrane
    Lesley J Bruce
    Department of Biochemistry, University of Bristol, United Kingom
    Blood 101:4180-8. 2003
    ..We speculate that this macrocomplex may function as an integrated CO(2)/O(2) gas exchange unit (metabolon) in the erythrocyte...
  11. doi Regulation of erythrocyte survival by AMP-activated protein kinase
    Michael Foller
    Department of Physiology, University of Tubingen, Tubingen, Germany
    FASEB J 23:1072-80. 2009
    ..The observations disclose a critical role of AMPK in the survival of circulating erythrocytes...
  12. doi A perforin-like protein mediates disruption of the erythrocyte membrane during egress of Plasmodium berghei male gametocytes
    Elena Deligianni
    Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Greece
    Cell Microbiol 15:1438-55. 2013
    ..analysis, and phenotype rescue with saponin or a pore-forming toxin, we conclude that rupture of the erythrocyte membrane is blocked in the mutant. The parasitophorous vacuole membrane, on the other hand, is ruptured normally...
  13. doi Tanshinone IIA stimulates erythrocyte phosphatidylserine exposure
    Christine Zelenak
    Department of Physiology, University of Tuebingen, Tuebingen, Germany
    Cell Physiol Biochem 30:282-94. 2012
    ..e. triggering of Ca(2+) entry, ATP depletion and ceramide formation in erythrocytes, events eventually leading to eryptosis with cell shrinkage and cell membrane scrambling...
  14. pmc Phosphorylation-dependent perturbations of the 4.1R-associated multiprotein complex of the erythrocyte membrane
    Emilie Gauthier
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA
    Biochemistry 50:4561-7. 2011
    ..1R results in structural changes transmitted to the functional interaction centers of the protein. We consider possible implications of our findings for the altered membrane function of normal reticulocytes and sickle red cells...
  15. doi Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    Janine Kröger
    Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    Am J Clin Nutr 93:127-42. 2011
    ..The long-term role of fatty acids (FAs) in the cause of diabetes remains largely unclear...
  16. doi Erythrocyte ageing in vivo and in vitro: structural aspects and implications for transfusion
    G J C G M Bosman
    Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Transfus Med 18:335-47. 2008
    ....
  17. pmc Trafficking of STEVOR to the Maurer's clefts in Plasmodium falciparum-infected erythrocytes
    Jude M Przyborski
    Hygiene Institut, Abteilung Parasitologie, Universitatsklinikum Heidelberg, Heidelberg, Germany
    EMBO J 24:2306-17. 2005
    ..Our data suggest general principles for transport of transmembrane proteins to the Maurer's clefts and provide new insights into protein sorting and trafficking processes in P. falciparum...
  18. doi Malaria parasite proteins that remodel the host erythrocyte
    Alexander G Maier
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria, Australia
    Nat Rev Microbiol 7:341-54. 2009
    Exported proteins of the malaria parasite Plasmodium falciparum interact with proteins of the erythrocyte membrane and induce substantial changes in the morphology, physiology and function of the host cell...
  19. pmc Native ultrastructure of the red cell cytoskeleton by cryo-electron tomography
    ANDREA NANS
    Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York, USA
    Biophys J 101:2341-50. 2011
    ..Based on comparisons with expanded skeletons, we propose that the oligomeric state of spectrin is in a dynamic equilibrium that facilitates remodeling of the network as the cell changes shape in response to shear stress...
  20. ncbi Targeting malaria virulence and remodeling proteins to the host erythrocyte
    Matthias Marti
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Science 306:1930-3. 2004
    ..a series of membranes, including the parasite membrane, the parasitophorous vacuole membrane, and the erythrocyte membrane. We show that a conserved pentameric sequence plays a central role in protein export into the host cell and ..
  21. doi Fatty acid composition of erythrocyte membrane lipids in healthy subjects from birth to young adulthood
    Viktoria Jakobik
    Department of Paediatrics, University of Pecs, József A u 7, Pecs 7623, Hungary
    Eur J Pediatr 168:141-7. 2009
    The fatty acid composition of erythrocyte membrane lipids may better reflect the fatty acid status of the organism than the fatty acid composition of plasma lipids...
  22. ncbi Protein kinase C mediates erythrocyte "programmed cell death" following glucose depletion
    Barbara A Klarl
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Am J Physiol Cell Physiol 290:C244-53. 2006
    ..The present observations suggest that protein phosphorylation and dephosphorylation via PKC and the corresponding protein phosphatases contribute to phosphatidylserine exposure and cell shrinkage after energy depletion...
  23. pmc Control of erythrocyte membrane-skeletal cohesion by the spectrin-membrane linkage
    Lionel Blanc
    Red Cell Physiology Laboratory, New York Blood Center, New York, New York 10065, USA
    Biochemistry 49:4516-23. 2010
    ..These findings enabled us to identify an additional important functional role for the spectrin-ankyrin-band 3 link in regulating spectrin self-association in the red cell membrane...
  24. ncbi A detailed study of time-dependent changes in human red blood cells: from reticulocyte maturation to erythrocyte senescence
    Sean C Gifford
    Visual and Circulatory Biophysics Laboratory, Department of Biomedical Engineering, Boston University, Boston, MA, USA
    Br J Haematol 135:395-404. 2006
    ..15%) and a model describing the complete time-course of diminishing mean RBC area and Hb is proposed. The relationship between the losses of Hb and area, and their possible influence on red cell lifespan, are discussed...
  25. doi Interaction between plant polyphenols and the erythrocyte membrane
    Sylwia Cyboran
    Department of Physics and Biophysics, Wrocław University of Environmental and Life Sciences, Poland
    Cell Mol Biol Lett 17:77-88. 2012
    ..of polyphenols contained in extracts from apple, strawberry and blackcurrant on the properties of the erythrocyte membrane, treated as a model of the biological membrane...
  26. pmc Metabolic remodeling of the human red blood cell membrane
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:1289-94. 2010
    ....
  27. ncbi Erythrocyte remodeling by malaria parasites
    Kasturi Haldar
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Curr Opin Hematol 14:203-9. 2007
    ..This review summarizes recent studies of the erythrocyte-malaria interaction that have provided insights into properties of erythrocyte membranes as well as parasite mechanisms that remodel the erythrocyte...
  28. ncbi Fatty acid profile of the erythrocyte membrane preceding development of Type 2 diabetes mellitus
    Benno Krachler
    Behavioural Medicine, Department of Public Health and Clinical Medicine, Umea University, SE 901 85 Umea, Sweden
    Nutr Metab Cardiovasc Dis 18:503-10. 2008
    The respective roles of dietary fatty acids in the pathogenesis of diabetes are as yet unclear. Erythrocyte membrane fatty acid (EMFA) composition may provide an estimate of dietary fatty acid intake...
  29. ncbi Isolation of cDNA coding for an ubiquitous membrane protein deficient in high Na+, low K+ stomatocytic erythrocytes
    G W Stewart
    Department of Medicine, University College and Middlesex Medical School, Rayne Institute, London, UK
    Blood 79:1593-601. 1992
    ..As a membrane-bound inhibitor protein of Na+ and K+ transport, it is unique among the known components of membrane-transport proteins...
  30. doi Nanotoxicity of TiO(2) nanoparticles to erythrocyte in vitro
    Shi qiang Li
    School of Life Science and Technology, Tongji University, Shanghai 200092, People s Republic of China
    Food Chem Toxicol 46:3626-31. 2008
    ..Our findings imply that nano-TiO(2) may have potential toxicity to human being health...
  31. pmc A two-compartment model of osmotic lysis in Plasmodium falciparum-infected erythrocytes
    Marissa A Wagner
    Molecular Physiology Unit, Laboratory of Malaria and Vector Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biophys J 84:116-23. 2003
    ..Our model and light scattering assay also revealed Michaelian kinetics for inhibition of PESAC by furosemide, suggesting a 1:1 stoichiometry for their interaction...
  32. pmc Protein 4.1R-deficient mice are viable but have erythroid membrane skeleton abnormalities
    Z T Shi
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Clin Invest 103:331-40. 1999
    ..1R expression is widespread among nonerythroid cells. The 4.1R knockout mice represent a valuable animal model for exploring 4.1R function in nonerythroid cells and for determining pathophysiological sequelae to 4.1R deficiency...
  33. pmc Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regions
    Thomas Lavstsen
    Centre for Medical Parasitology at Institute for Medical Microbiology and Immunology, University of Copenhagen, Denmark
    Malar J 2:27. 2003
    The variant surface antigen family Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) is an important target for protective immunity and is implicated in the pathology of malaria through its ability to adhere to host ..
  34. ncbi Reduced red blood cell membrane essential polyunsaturated fatty acids in first episode schizophrenia at neuroleptic-naive baseline
    Ravinder D Reddy
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Schizophr Bull 30:901-11. 2004
    ..The findings also suggest that membrane fatty acid losses are quite specific to the highly unsaturated fatty acids...
  35. pmc Two non-vesicular ATP release pathways in the mouse erythrocyte membrane
    Feng Qiu
    Department of Physiology and Biophysics, University of Miami, School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA
    FEBS Lett 585:3430-5. 2011
    ..Thus, in erythrocytes, two independent pathways mediate the release of ATP. We also show that glyburide is a strong inhibitor of Panx1 channels...
  36. doi Beauvericin induced erythrocyte cell membrane scrambling
    Syed M Qadri
    Department of Physiology, University of Tubingen, Gmelinstr 5, 72076 Tubingen, Germany
    Toxicology 283:24-31. 2011
    ..The present observations disclose novel effects of beauvericin, i.e. stimulation of Ca²+ entry with subsequent cell membrane scrambling and inhibition of Ca²+ activated K+ channels with blunting of cell shrinkage...
  37. doi Band 3 multiprotein complexes in the red cell membrane; of mice and men
    Emile van den Akker
    Department of Biochemistry, School of Medical Sciences, University Walk, Bristol, UK
    Blood Cells Mol Dis 45:1-8. 2010
    The bicarbonate/chloride exchanger band 3 (Anion Exchanger 1, AE1) is the most abundant protein in the erythrocyte membrane, it has an important role in gas exchange and functions as a point of attachment for the cytoskeletons maintaining ..
  38. doi The role of red blood cells in the progression and instability of atherosclerotic plaque
    Dimitrios N Tziakas
    University Cardiology Department, Medical School, Democritus University of Thrace, Voulgaroktonou 23, 68100 Alexandroupolis, Greece
    Int J Cardiol 142:2-7. 2010
    ..Finally, some elements that may be clinically important regarding erythrocytes in coronary artery disease are discussed...
  39. doi Carbon monoxide-sensitive apoptotic death of erythrocytes
    Elisabeth Lang
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Basic Clin Pharmacol Toxicol 111:348-55. 2012
    ..In conclusion, CORM-2 stimulates cell membrane scrambling of erythrocytes, an effect largely due to Ca²⁺ entry and partially reversed by O₂...
  40. ncbi Participation of leukotriene C(4) in the regulation of suicidal erythrocyte death
    M Foller
    Department of Physiology, University of Tubingen, Germany
    J Physiol Pharmacol 60:135-43. 2009
    ..Cysteinyl-leukotrienes thus participate in the signaling of eryptosis during energy depletion...
  41. doi Dicoumarol activates Ca2+-permeable cation channels triggering erythrocyte cell membrane scrambling
    Syed M Qadri
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 28:857-64. 2011
    ..In conclusion, dicoumarol stimulates suicidal death of erythrocytes by stimulating Ca(2+) entry and subsequent triggering of Ca(2+) dependent cell membrane scrambling...
  42. doi The functional importance of blood group-active molecules in human red blood cells
    D J Anstee
    Bristol Institute for Transfusion Sciences, NHS Blood and Transplant, Bristol, UK
    Vox Sang 100:140-9. 2011
    ..Dyserythropoiesis with reduced antigen expression can result from mutations in the erythroid transcription factors GATA-1 and EKLF...
  43. ncbi Acidic and neutral sialidase in the erythrocyte membrane of type 2 diabetic patients
    Bruno Venerando
    Department of Medical Chemistry and Biochemistry, School of Medicine, University of Milan, LITA, Via Fratelli Cervi, 93 20090 Segrate, Milan, Italy
    Blood 99:1064-70. 2002
    The behavior of the 2 sialidase forms present in the erythrocyte membrane was investigated in 117 subjects with type 2 diabetes mellitus versus 95 healthy controls...
  44. doi Erythrocyte vesiculation: a self-protective mechanism?
    Frans L A Willekens
    Department of Clinical Chemistry, Rijnstate Hospital, Arnhem, The Netherlands
    Br J Haematol 141:549-56. 2008
    ..It was concluded that vesiculation constitutes a mechanism for the removal of erythrocyte membrane patches containing removal molecules, thereby postponing the untimely elimination of otherwise healthy ..
  45. ncbi Protein 4.1, a component of the erythrocyte membrane skeleton and its related homologue proteins forming the protein 4.1/FERM superfamily
    Witold Diakowski
    Faculty of Biotechnology, University of Wrocław, Wrocław, Poland
    Folia Histochem Cytobiol 44:231-48. 2006
    ....
  46. pmc Enhanced suicidal erythrocyte death in mice carrying a loss-of-function mutation of the adenomatous polyposis coli gene
    Syed M Qadri
    Department of Physiology, University of Tubingen, Tubingen, Germany
    J Cell Mol Med 16:1085-93. 2012
    ..The observations point to accelerated eryptosis and subsequent clearance of apc(Min/+) erythrocytes, which contributes to or even accounts for the enhanced erythrocyte turnover, anaemia and splenomegaly in those mice...
  47. pmc Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane
    Marcela Salomao
    Red Cell Physiology Laboratory and Membrane Biochemistry Laboratory, New York Blood Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 105:8026-31. 2008
    ....
  48. doi Hexavalent chromium-induced erythrocyte membrane phospholipid asymmetry
    Adrian Lupescu
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Biometals 25:309-18. 2012
    ..The present observations disclose a novel effect of chromium (VI), i.e. Ca(2+) entry and cytosolic ATP depletion in erythrocytes, effects resulting in eryptosis with cell shrinkage and cell membrane scrambling...
  49. ncbi Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid
    F Basse
    Blood Research Institute of The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin 53201, USA
    J Biol Chem 271:17205-10. 1996
    ..3-diazol-4-yl-PL between membrane leaflets, with half-maximal activation between 20 and 60 microM Ca2+ (saturation >100 microM), mimicking the Ca2+-dependent transbilayer lipid movement intrinsic to the erythrocyte membrane.
  50. ncbi Modulation of erythrocyte membrane mechanical function by protein 4.1 phosphorylation
    Sumie Manno
    Department of Biochemistry, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    J Biol Chem 280:7581-7. 2005
    b>Erythrocyte membrane mechanical function is regulated by the spectrin-based membrane skeleton composed of alpha- and beta-spectrin, actin, protein 4.1R (4.1R), and adducin...
  51. ncbi Damage to the structure of erythrocyte plasma membranes in patients with type-2 hypercholesterolemia
    Maria Koter
    Department of Environment Pollution Biophysics, University of Lodz, 12 16 Banacha St, 90 347, Lodz, Poland
    Int J Biochem Cell Biol 36:205-15. 2004
    ..The study involved 60 hypercholesterolemic patients and 30 healthy individuals as the control group...
  52. ncbi Glycophorin C is the receptor for the Plasmodium falciparum erythrocyte binding ligand PfEBP-2 (baebl)
    Cheryl Ann Lobo
    Department of Molecular Parasitology, The Lindsley Kimball Research Institute, New York Blood Center, NY, NY 10021
    Blood 101:4628-31. 2003
    ..Thus PfEBP-2 is involved in a sialic acid-dependent pathway of invasion, which does not involve glycophorin A or glycophorin B and represents a novel route of entry into the RBCs...
  53. ncbi In-depth analysis of the membrane and cytosolic proteome of red blood cells
    Erica M Pasini
    Department of Proteomics and Signal Transduction, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Blood 108:791-801. 2006
    ..Our data reveal unexpected complexity of the RBC proteome, provide a wealth of data on its composition, shed light on several open issues in RBC biology, and form a departure point for comprehensive understanding of RBC functions...
  54. pmc The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1
    J C Reeder
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 96:5198-202. 1999
    ..falciparum erythrocyte membrane protein 1 product of the gene is the parasite ligand mediating CSA binding...
  55. pmc Skeleton-binding protein 1 functions at the parasitophorous vacuole membrane to traffic PfEMP1 to the Plasmodium falciparum-infected erythrocyte surface
    Alexander G Maier
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 109:1289-97. 2007
    ..The major virulence factor and variant surface protein PfEMP1 (P falciparum erythrocyte membrane protein 1) acts as a ligand to adhere to endothelial receptors avoiding splenic clearance...
  56. pmc Assembly and regulation of a glycolytic enzyme complex on the human erythrocyte membrane
    M Estela Campanella
    Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 102:2402-7. 2005
    ..We conclude, therefore, that GEs are organized into complexes on the membrane whose assembly is regulated by oxygenation and phosphorylation...
  57. ncbi The malaria-infected red blood cell: structural and functional changes
    B M Cooke
    Department of Microbiology, P.O. Box 53, Monash University, Victoria 3800, Australia
    Adv Parasitol 50:1-86. 2001
    ..Furthermore, interference with these interactions may lead to previously unsuspected means of reducing parasite virulence and may lead to the development of novel antimalarial therapeutics...
  58. pmc Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes
    Anja T R Jensen
    Department of Medical Microbiology and Immunology, The Panum Institute, Building 24 2, Blegdamsvej 3, 2200 Copenhagen, Denmark
    J Exp Med 199:1179-90. 2004
    Parasite-encoded variant surface antigens (VSAs) like the var gene-encoded Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family are responsible for antigenic variation and infected red blood cell (RBC) cytoadhesion in P...
  59. pmc Adducin forms a bridge between the erythrocyte membrane and its cytoskeleton and regulates membrane cohesion
    William A Anong
    Department of Chemistry, Purdue University, West Lafayette, IN 47907 2084, USA
    Blood 114:1904-12. 2009
    The erythrocyte membrane skeleton is the best understood cytoskeleton. Because its protein components have homologs in virtually all other cells, the membrane serves as a fundamental model of biologic membranes...
  60. ncbi Erythrocyte detergent-resistant membrane proteins: their characterization and selective uptake during malarial infection
    Sean C Murphy
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Blood 103:1920-8. 2004
    ....
  61. ncbi Erythrocyte G protein-coupled receptor signaling in malarial infection
    Travis Harrison
    Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 Chicago Avenue, Chicago, IL 60611, USA
    Science 301:1734-6. 2003
    ..berghei infections in an in vivo mouse model. Thus, signaling via the erythrocyte beta2-adrenergic receptor and Galphas may regulate malarial infection across parasite species...
  62. doi Multiple stages of detergent-erythrocyte membrane interaction--a spin label study
    Paulo S C Preté
    Department of Biochemistry, Institute of Biology, State University of Campinas, SP, Brazil
    Biochim Biophys Acta 1808:164-70. 2011
    ..This analysis is in agreement with the models proposed by Lasch (Biochim. Biophys Acta 1241 (1995) 269-292) and by Le Maire and coworkers (Biochim. Biophys. Acta 1508 (2000) 86-111)...
  63. pmc Reductions of erythrocyte membrane viscoelastic coefficients reflect spectrin deficiencies in hereditary spherocytosis
    R E Waugh
    Department of Biophysics, University of Rochester School of Medicine and Dentistry, New York 14642
    J Clin Invest 81:133-41. 1988
    ..a common hemolytic anemia associated with deficiencies in spectrin, the principal structural protein of the erythrocyte membrane-skeleton...
  64. doi Comparison of fatty acid contents of erythrocyte membrane in hemodialysis and peritoneal dialysis patients
    W S An
    Department of Internal Medicine, Dong A University, Busan, Republic of Korea
    J Ren Nutr 19:267-74. 2009
    ..Given the impact of ethnic and dietary factors, we sought to examine membrane fatty acid composition in an ethnically homogeneous end-stage renal disease population residing in a coastal region of Korea with high fish consumption...
  65. doi Spatial analysis of erythrocyte membrane fluctuations by digital holographic microscopy
    Benjamin Rappaz
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Blood Cells Mol Dis 42:228-32. 2009
    ..CMF amplitudes of 35.9+/-8.9 nm and 4.7+/-0.5 nm (averaged over the cell surface) were determined for normal and ethanol-fixed RBCs, respectively...
  66. pmc Dematin and adducin provide a novel link between the spectrin cytoskeleton and human erythrocyte membrane by directly interacting with glucose transporter-1
    Anwar A Khan
    Department of Pharmacology, University of Illinois Cancer Center, University of Illinois College of Medicine, Chicago, IL 60612, USA
    J Biol Chem 283:14600-9. 2008
    ..actin-binding proteins located at the spectrin-actin junctions, also called the junctional complex, in the erythrocyte membrane. Here we propose a new model whereby dematin and adducin link the junctional complex to human erythrocyte ..
  67. pmc Capsid region involved in hepatitis A virus binding to glycophorin A of the erythrocyte membrane
    Gloria Sanchez
    Department of Microbiology, University of Barcelona, Av Diagonal 645, 08028 Barcelona, Spain
    J Virol 78:9807-13. 2004
    ....
  68. ncbi Plasmodium falciparum erythrocyte membrane protein-1 specifically suppresses early production of host interferon-gamma
    Marthe C D'Ombrain
    Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Cell Host Microbe 2:130-8. 2007
    Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a variable antigen expressed by P. falciparum, the malarial parasite...
  69. ncbi Adverse effect of obesity on red cell membrane arachidonic and docosahexaenoic acids in gestational diabetes
    Y Min
    Institute of Brain Chemistry and Human Nutrition, London Metropolitan University, 166 220 Holloway Road, N7 8DB London, UK
    Diabetologia 47:75-81. 2004
    ..We investigated the plasma and red cell fatty acid status of gestational diabetes. The effect of obesity on membrane fatty acids was also examined...
  70. doi Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients
    W S An
    Department of Internal Medicine, Dong A University College of Medicine, Busan, Republic of Korea
    Prostaglandins Leukot Essent Fatty Acids 86:29-34. 2012
    b>Erythrocyte membrane fatty acids (FA), such as oleic acid, are related to acute coronary syndrome. There is no report about the effect of omega-3 FA on oleic acid in peritoneal dialysis (PD) patients...
  71. ncbi Hydroxyurea attenuates activated neutrophil-mediated sickle erythrocyte membrane phosphatidylserine exposure and adhesion to pulmonary vascular endothelium
    Johnson Haynes
    Comprehensive Sickle Cell Center, Department of Medicine, University of South Alabama Medical Center, 2451 Fillingim Street, Mobile, AL 36617, USA
    Am J Physiol Heart Circ Physiol 294:H379-85. 2008
    ....
  72. doi Interaction of mesoporous silica nanoparticles with human red blood cell membranes: size and surface effects
    Yannan Zhao
    Department of Chemistry, U S Department of Energy Ames Laboratory, Iowa State University, Ames, Iowa 50011 3111, USA
    ACS Nano 5:1366-75. 2011
    ....
  73. ncbi Atomic force microscopy of the erythrocyte membrane skeleton
    A H Swihart
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
    J Microsc 204:212-25. 2001
    ..This study demonstrates the applicability of AFM for imaging the erythrocyte membrane skeleton at a resolution that appears adequate to identify major components of the membrane skeleton under ..
  74. doi Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes
    Yuvaraj Mahendran
    Institute of Clinical Sciences, Internal Medicine YM, HC, JV, As, JK, and ML, the Institute of Biomedicine Physiology JÅ, and the Institute of Public Health and Clinical Nutrition MU and US, University of Eastern Finland, Kuopio, Finland, and the Research Unit MU and the Department of Medicine HC, JK, and ML, Kuopio University Hospital, Kuopio, Finland
    Am J Clin Nutr 99:79-85. 2014
    The significance of erythrocyte membrane fatty acids (EMFAs) and their ratios to predict hyperglycemia and incident type 2 diabetes is unclear.
  75. ncbi Assignment of functional roles to parasite proteins in malaria-infected red blood cells by competitive flow-based adhesion assay
    Brian M Cooke
    Department of Microbiology, Monash University, Victoria, Australia
    Br J Haematol 117:203-11. 2002
    ..erythrocyte surface antigen (RESA), knob-associated histidine-rich protein (KAHRP) or Plasmodium falciparum erythrocyte membrane protein 3 (PfEMP3) had a significant effect on the ability of PRBCs to adhere, whereas loss of mature ..
  76. pmc Dematin, a component of the erythrocyte membrane skeleton, is internalized by the malaria parasite and associates with Plasmodium 14-3-3
    Marco Lalle
    Dipartimento di Malattie Infettive, Istituto Superiore di Sanita, 00161 Rome, Italy
    J Biol Chem 286:1227-36. 2011
    ..cell directed by the parasite also includes the recruitment of dematin, an actin-binding protein of the erythrocyte membrane skeleton and its repositioning to the parasite...
  77. doi Addition of oligosaccharide decreases the freezing lesions on human red blood cell membrane in the presence of dextran and glucose
    Guo Bo Quan
    Beijing Institute of Transfusion Medicine, The Taiping Road 27, The Haidian County, Beijing, China
    Cryobiology 62:135-44. 2011
    ..In conclusion, addition of oligosaccharide can efficiently reduce lesions of freezing on red blood cell membrane in the presence of glucose and dextran...
  78. pmc Allelic diversity of the Plasmodium falciparum erythrocyte membrane protein 1 entails variant-specific red cell surface epitopes
    Inès Vigan-Womas
    Institut Pasteur, Unité d Immunologie Moléculaire des Parasites, Paris, France
    PLoS ONE 6:e16544. 2011
    ....
  79. pmc The ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum stabilizes spectrin tetramers and suppresses further invasion
    Xinhong Pei
    Red Cell Physiology Laboratory, New York Blood Center, 310 E 67th Street, New York, NY 10021, USA
    Blood 110:1036-42. 2007
    ....
  80. ncbi Generation of an erythrocyte vesicle transport system by Plasmodium falciparum malaria parasites
    Theodore F Taraschi
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St, Philadelphia, PA 19107, USA
    Blood 102:3420-6. 2003
    ..It is proposed that the parasite adapted a process well established for intracellular transport to mediate the extracellular movement of its proteins through the erythrocyte cytosol to the surface membrane...
  81. pmc Headpiece domain of dematin is required for the stability of the erythrocyte membrane
    Richie Khanna
    Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Proc Natl Acad Sci U S A 99:6637-42. 2002
    Dematin is an actin-binding and bundling protein of the erythrocyte membrane skeleton. Dematin is localized to the spectrin-actin junctions, and its actin-bundling activity is regulated by phosphorylation of cAMP-dependent protein kinase...
  82. doi Effects of duration of treatment and dosage of eicosapentaenoic acid and stearidonic acid on red blood cell eicosapentaenoic acid content
    E S Krul
    Solae LLC, 4300 Duncan Avenue, St Louis, MO 63110, USA
    Prostaglandins Leukot Essent Fatty Acids 86:51-9. 2012
    ....
  83. ncbi Altered erythrocyte n-3 fatty acids in Mediterranean patients with coronary artery disease
    F Paganelli
    Division of Cardiology, , School of Medicine, Marseille, France
    Int J Cardiol 78:27-32. 2001
    ..Our data suggest that the percentage of docosahexaenoic and docosapentaenoic acids in erythrocytes could be used as indicators of an independent risk factor for coronary artery disease...
  84. ncbi Protection against clinical malaria by heterologous immunoglobulin G antibodies against malaria-infected erythrocyte variant surface antigens requires interaction with asymptomatic infections
    Samson M Kinyanjui
    Kenya Medical Research Institute Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    J Infect Dis 190:1527-33. 2004
    ..falciparum erythrocyte membrane protein 1...
  85. doi Association between vascular calcification scores on plain radiographs and fatty acid contents of erythrocyte membrane in hemodialysis patients
    Young K Son
    Department of Internal Medicine, Dong A University, Seo Gu, Busan, Republic of Korea
    J Ren Nutr 22:58-66. 2012
    ..FA) has been shown to reduce ectopic calcifications in an animal model, and it has also been shown that erythrocyte membrane omega-3 FA content is an independent discriminator of coronary artery disease...
  86. doi Induction of programmed erythrocyte death by gambogic acid
    Adrian Lupescu
    Department of Physiology, University of Tubingen, Gmelinstrasse 5, Tubingen, Germany
    Cell Physiol Biochem 30:428-38. 2012
    ..The present observations disclose a novel effect of gambogic acid, i.e. stimulation of suicidal death of human erythrocytes or eryptosis, paralleled by Ca(2+)-entry, ceramide formation, cell shrinkage and phosphatidylserine-exposure...
  87. pmc Tropomyosin modulates erythrocyte membrane stability
    Xiuli An
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10021, USA
    Blood 109:1284-8. 2007
    The ternary complex of spectrin, actin, and 4.1R (human erythrocyte protein 4.1) defines the nodes of the erythrocyte membrane skeletal network and is inseparable from membrane stability under mechanical stress...
  88. ncbi Comparison of changes in erythrocyte and platelet phospholipid and fatty acid composition and protein oxidation in chronic obstructive pulmonary disease and asthma
    Javier de Castro
    Radiology Service, Santísima Trinidad Foundation Hospital, Salamanca, Spain
    Platelets 18:43-51. 2007
    ....
  89. ncbi Prostaglandin E2 activates channel-mediated calcium entry in human erythrocytes: an indication for a blood clot formation supporting process
    Lars Kaestner
    Institute for Molecular Cell Biology, Faculty of Medicine, Building 61, Saarland University, 66421 Homburg Saar, Germany
    Thromb Haemost 92:1269-72. 2004
    ..Therefore, we conclude that the PGE(2) responses of red blood cells described here reveal a direct and active participation of erythrocytes in blood clot formation...
  90. pmc Omega-6 and trans fatty acids in blood cell membranes: a risk factor for acute coronary syndromes?
    Robert C Block
    Division of Epidemiology, Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Am Heart J 156:1117-23. 2008
    ..Although fatty acid intake has been associated with risk of coronary disease events, the association between blood omega-6 and trans fatty acids (FAs) at the time of an acute coronary syndrome (ACS) is unknown...
  91. ncbi Identification of oxidized methionine sites in erythrocyte membrane protein by liquid chromatography/electrospray ionization mass spectrometry peptide mapping
    Chunyan Li
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochemistry 45:12117-24. 2006
    ..ionization mass spectrometry (LC/ESI MS) to examine the methionine oxidation of band 3 of erythrocyte membrane protein...
  92. ncbi Dynamic and electrokinetic behavior of erythrocyte membrane in diabetes mellitus and diabetic cardiovascular disease
    Sangeeta Adak
    Department of Biochemistry, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, India
    Biochim Biophys Acta 1780:108-15. 2008
    The dynamic and electrokinetic properties of erythrocyte membrane are explored as significant indices involved in the association of diabetes and diabetic cardiovascular disease...
  93. pmc Plasmodium falciparum FIKK kinase members target distinct components of the erythrocyte membrane
    Marta C Nunes
    Unité de Biologie des Interactions Hôte Parasite, CNRS UR2581 Institut Pasteur, Paris, France
    PLoS ONE 5:e11747. 2010
    ....
  94. pmc Peroxiredoxin-2 expression is increased in beta-thalassemic mouse red cells but is displaced from the membrane as a marker of oxidative stress
    Alessandro Matte
    Section of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, 37134 Verona, Italy
    Free Radic Biol Med 49:457-66. 2010
    ..Thus, reduced access of Prx2 to the membrane in beta-thal RBCs represents a new factor that could contribute to the oxidative damage characterizing the pathology...
  95. ncbi Growth of Plasmodium falciparum induces stage-dependent haemichrome formation, oxidative aggregation of band 3, membrane deposition of complement and antibodies, and phagocytosis of parasitized erythrocytes
    G Giribaldi
    Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy
    Br J Haematol 113:492-9. 2001
    ....
  96. pmc Deficiency of skeletal membrane protein band 4.1 in homozygous hereditary elliptocytosis. Implications for erythrocyte membrane stability
    G Tchernia
    J Clin Invest 68:454-60. 1981
    ..The parallel findings of markedly reduced levels of band 4.1 in the erythrocyte membrane proteins of the patients and an intermediate reduction in the cells of the parents and the putative ..
  97. pmc Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:13730-5. 2008
    ..These findings offer potential, and sufficiently general, avenues for identifying, through cell membrane dynamics, pathological states that cause or accompany human diseases...
  98. pmc Increased ability of erythrocytes to aggregate in spontaneously hypertensive rats
    David Lominadze
    Department of Physiology and Biophysics, University of Louisville, KY, USA
    Clin Exp Hypertens 24:397-406. 2002
    ..These results show that increased RBC aggregability is accompanied by alterations in RBC membrane protein composition during hypertension development...
  99. pmc Fluctuations of the red blood cell membrane: relation to mechanical properties and lack of ATP dependence
    James Evans
    King s College London, Randall Division of Cell and Molecular Biophysics, Guy s Campus, London, United Kingdom
    Biophys J 94:4134-44. 2008
    ..We conclude that the membrane fluctuations of the red cell are governed by bending modulus, membrane tension, and cytosolic viscosity, with little or no dependence on the presence or absence of ATP...
  100. doi RBC-derived vesicles during storage: ultrastructure, protein composition, oxidation, and signaling components
    Anastasios G Kriebardis
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Greece
    Transfusion 48:1943-53. 2008
    ..The vesiculation of the RBCs is a part of the storage lesion. The protein composition of the vesicles generated during storage of banked RBCs has not been studied in detail...
  101. pmc Identification of glycosaminoglycan binding domains in Plasmodium falciparum erythrocyte membrane protein 1 of a chondroitin sulfate A-adherent parasite
    J C Reeder
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Infect Immun 68:3923-6. 2000
    ..This process is mediated in part by the parasite ligand P. falciparum erythrocyte membrane protein 1 (PfEMP1) at the surface of the infected erythrocyte interacting with the host receptor ..

Research Grants64

  1. Molecular Biology of Human Erythrocyte Alpha Spectrin
    Patrick G Gallagher; Fiscal Year: 2013
    ..involved in normal and abnormal expression of the protein 1-spectrin, a critical component of the erythrocyte membrane skeleton...
  2. Molecular pathogenesis and genetic diversification of childhood falciparum malari
    STEVE MYER TAYLOR; Fiscal Year: 2013
    ..falciparum var virulence genes that encode the P. falciparum erythrocyte membrane protein 1 (PfEMP1)...
  3. Identification of a Molecular Signature for Barrier Insulators
    LAURIE ANN STEINER; Fiscal Year: 2013
    ..of a previously identified group of potential barrier insulators, located in a focus group of erythrocyte membrane protein genes...
  4. P.falciparum var gene diversity and malaria control
    KAREN PATRICIA DAY; Fiscal Year: 2013
    ..The var multigene family encodes P. falciparum Erythrocyte Membrane Protein-1 (PfEMP1), a molecule that is expressed on the surface of erythrocytes infected by asexual ..
  5. Rac1 and Rac2 Guanosine Triphosphatases in Erythroid Function and Differentiation
    THEODOSIA ANASTASIOS KALFA; Fiscal Year: 2012
    ..abstract_text> ..
  6. The Plasmodium 2TM and PHIST protein families
    Thomas J Templeton; Fiscal Year: 2012
    ..the subject of this proposal: the predicted 2 transmembrane (2TM) proteins that likely function within the erythrocyte membrane, including the RIFIN, STEVOR and Pfmc-2TM families, and the PHIST domain family which likely function ..
  7. The role of Dock4 in normal and aberrant erythropoiesis
    Amittha Wickrema; Fiscal Year: 2013
    ..survival during the initial phase, very little is known with respect to signaling during late- stages of erythrocyte membrane remodeling, enucleation and reticulocyte maturation...
  8. Cytoskeletal Regulation of Erythrocyte Glucose Transporter-1
    Athar H Chishti; Fiscal Year: 2012
    ..dematin and adducin with several potential membrane proteins identified in our proteomics screen of mouse erythrocyte membrane vesicles...
  9. Impact of seasonality and vector control on population structure of P.falciparum
    Mercedes Pascual; Fiscal Year: 2013
    ..proposed to be largely driven by immune selection to the major surface antigen ofthe blood stages known as erythrocyte membrane protein 1 (PfEMPI) encoded by up to 60 members ofthe var multigene family per haploid genome...
  10. Novel Plasmodial Surface Anion Channel Inhibitors as Antimalarial Drugs
    Michelle M Butler; Fiscal Year: 2013
    ..The channel is produced by the parasite and inserts into the infected erythrocyte membrane. It was recently demonstrated that PSAC inhibitors, discovered by high-throughput screening, kills ..
  11. 3D Dynamics of Protein Network Coupled to Lipid Bilayer in Diseased Erythocytes
    Qiang Zhu; Fiscal Year: 2010
    ..Here we specifically study the erythrocyte membrane which has a protein network coupled to a lipid bilayer...
  12. Regulation of Erythrocyte Function
    Philip Stewart Low; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The structure of the human erythrocyte membrane is described in virtually every modern Cell Biology and Hematology text, because: i) it constitutes a useful model of other plasma membranes, ii) its ..
  13. Tubovesicular traffic induced in red cells in plasmodia
    Kasturi Haldar; Fiscal Year: 2012
    ..imaging techniques and biochemical subcellular fractionation assays will be used to identify and purify erythrocyte membrane components that are recruited into the vacuole and evauate their interactions with specific lipids and ..
  14. High throughput screening for anti-adhesion drugs to treat severe malaria
    Andrew V Oleinikov; Fiscal Year: 2010
    ..PE adhesion involves a large family (~60 members) of variant surface- expressed erythrocyte membrane proteins called PfEMP1...
  15. Functional Studies of Erythrocyte Dematin
    Athar H Chishti; Fiscal Year: 2010
    It is well recognized that the "spectrin-actin junctions" are functionally essential for the maintenance of erythrocyte membrane stability and mechanical properties...
  16. Detecting Which Patients With Schizophrenia Will Improve With Omega 3 Treatment
    Philip R Szeszko; Fiscal Year: 2013
    ..b>Erythrocyte membrane omega-3 concentration is a possible response marker given that it has been demonstrated to be abnormal in ..
  17. Mechanism of malaria parasite egress from erythrocytes
    May M Paing; Fiscal Year: 2010
    ..While within the infected RBCs, the developing merozoite is surrounded by erythrocyte membrane and parasitophorous vacuolar membrane (PVM), both of which must be broken down for egress...
  18. Molecular Analysis of the PfEMP1 Binding Activity
    JOSEPH DOUGLAS SMITH; Fiscal Year: 2013
    ..falciparum erythrocyte membrane protein 1 (PfEMP1)...
  19. Role of Red Cell Membrane in Malaria Parasite Release
    Manjit Hanspal; Fiscal Year: 2006
    ..Recently, we identified a novel P. falciparum cysteine protease named falcipain-2 (FP-2) that cleaves host erythrocyte membrane ankyrin, protein 4...
  20. Binding Mechanisms in P.falciparum Cerebral Malaria
    JOSEPH DOUGLAS SMITH; Fiscal Year: 2013
    ..IE binding is primarily mediated by a large family of proteins, called the var genes or P. falciparum erythrocyte membrane protein 1 (PfEMP1)...
  21. ERYTHROCYTE ADHESION IN FALCIPARUM MALARIA
    IRWIN SHERMAN; Fiscal Year: 2004
    ..It is known that increased adhesiveness of the PE is due to parasite-induced changes in the erythrocyte membrane protein, band 3, as well as the surface exposure of parasite-encoded proteins...
  22. PHOSPHOINOSITIDE REGULATION OF ERYTHROCYTE CYTOSKELETON
    Richard Andersen; Fiscal Year: 1991
    ..The RBC is the perfect, perhaps the only, paradigm to study at the molecular level PPI regulation of cytoskeletal-membrane associations...
  23. CAPPING ACTIN GROWTH IN ERYTHROID NONERYTHROID CELLS
    Velia Fowler; Fiscal Year: 2004
    Actin filament lengths are precisely regulated and very stable in the erythrocyte membrane skeleton and the sarcomers of striated muscle...
  24. Protein Structure and Dynamics from EPR Spectroscopy and MD Simulations
    Terry P Lybrand; Fiscal Year: 2012
    ..1-3 to SDSL data obtained for T4 lysozyme, a model protein of known structure, for CDB3, a more complex erythrocyte membrane protein that is to date only partially characterized structurally, and for amyloid precursor protein ..
  25. MOLECULAR BIOLOGY OF HUMAN ERYTHROCYTE ANKYRIN
    Patrick Gallagher; Fiscal Year: 2000
    ..Erythrocyte ankyrin, an important component of the erythrocyte membrane skeleton, is the prototype of a family of homologous proteins that serve as linker/adaptor molecules ..
  26. Adherence of malaria-infected red cells
    Alan Cowman; Fiscal Year: 2009
    ..to these changes are proteins of parasite origin that are either deposited on the inner aspect of the erythrocyte membrane or inserted into it...
  27. MOLECULAR INTERACTIONS OF BRAIN SPECTRIN
    Leszek Kotula; Fiscal Year: 1999
    ..Defects in the erythrocyte membrane skeleton integral proteins underlie some hereditary hemolytic anemias in humans and mice, and recent ..
  28. PHOSPHOINOSITIDES IN NORMAL AND ABNORMAL HUMAN RED CELLS
    George Dale; Fiscal Year: 1992
    Phosphoinositides present in the erythrocyte membrane have a unique function when compared to many other cell types...
  29. INSULIN AND PROSTACYCLIN IN ISCHEMIC HEART DISEASE
    ASRU SINHA; Fiscal Year: 1990
    ..insulin receptors of target cells in general by determining the hormone receptor activity of the patients' erythrocyte membrane and compare it with that of normal red cell ghosts...
  30. MOLECULAR ANALYSIS OF ANTIGENIC VARIATION IN MALARIA
    Mary Galinski; Fiscal Year: 2000
    ..antigens are high molecular weight, parasite-encoded proteins that are inserted into the infected host erythrocyte membrane and are partially exposed at its surface...
  31. HUMAN ERYTHROCYTE MEMBRANE REGULATION OF COMPLEMENT
    Charles Parker; Fiscal Year: 1990
    ..The inactivator will be isolated from solubilized erythrocyte membrane by affinity chromatography using immobilized C6, and antibodies will be produced...
  32. EPR STUDIES OF MEMBRANE PROTEINS
    ALBERT BETH; Fiscal Year: 2007
    The anion exchange protein (band 3) is an abundant protein in the human[unreadable] erythrocyte membrane which is composed of two domains that serve[unreadable] distinct functions...
  33. RECEPTOR MEDIATED PINOCYTOSIS IN PLASMODIUM
    Kasturi Haldar; Fiscal Year: 1990
    ..There is evidence for directed transport of plasmodial proteins to the infected erythrocyte membrane which results in the modification of the structure and functions of host membranes...
  34. DEFERIPRONE THERAPY FOR SICKLE CELL DISEASE
    Nancy Olivieri; Fiscal Year: 2001
    ..chronic hemolytic anemia of sickle cell disease by inhibiting iron-induced oxidative damage to the sickle erythrocyte membrane and decreasing red cell destruction...
  35. Red blood cell polymorphisms and malaria in PNG
    SHERAL PATEL; Fiscal Year: 2004
    ..The aims of this project are to 1.) investigate whether known polymorphisms in erythrocyte membrane proteins, including band 3, glycophorin C, spectrin, protein 4...
  36. MICROPHOTOHEMOLYSIS TO MEASURE ERYTHROCYTE FRAGILITY
    Frederick Miller; Fiscal Year: 1991
    b>Erythrocyte membrane fragility may be altered by disease, age, and drugs and plays an important role in the survival and function of the erythrocyte...
  37. TISSUE VITAMIN E LEVELS AND PROSTATE CANCER RISK
    Paul Godley; Fiscal Year: 2000
    ..to test the hypothesis that consumption of alpha-tocopherol increases prostate cancer risk using stored erythrocyte membrane and adipose tissue samples from a case- control study of fatty acids and prostate cancer risk...
  38. MECHANISM OF LYMPHOCYTE CYTOTOXICITY AND SELF-PROTECTION
    LEORA ZALMAN; Fiscal Year: 1991
    ..This phenomenon appears to be mediated by an erythrocyte membrane protein that we have designated homologous restriction factor (HRF)...
  39. DECIPHERING THE FUNCTION OF THE RH BLOOD GROUP PROTEINS
    Connie Westhoff; Fiscal Year: 2002
    ..targets of immune responses, Rh proteins appear to have an important functional or structural role in the erythrocyte membrane, as individuals who lack expression of all Rh antigens suffer from chronic hemolytic anemia...
  40. Studies of the Immunopathogenesis of Type 1 Diabetes
    Jin Xiong She; Fiscal Year: 2006
    ..between a modulator of PGS-2 activity - dietary n-3 polyunsaturated fatty acids - and BCA by analyzing erythrocyte membrane fatty acid levels in Ab+ subjects and matched controls...
  41. THE SYNTHESIS AND PROPERTIES OF MEMBRANE PEPTIDES
    RICHARD GALARDY; Fiscal Year: 1980
    ..the hydrophobic intramembraneous peptide of glycophorin A, the major sialoglycoprotein of the human erythrocyte membrane and to investigate the secondary structure, aggregation properties, and lipid binding properties of this ..
  42. HEMOGLOBIN AND ERYTHROCYTE MEMBRANE INTERACTION
    BANGALORE PREMACHANDRA; Fiscal Year: 1990
    ..alpha and beta chains of Hb isolated from normal (AA) and sickle (SS) blood, on AA and SS inside out erythrocyte membrane vesicles (IOVs) on a comparative basis...
  43. The Glycosylation Gap and Diabetic Complications
    Robert Cohen; Fiscal Year: 2005
    ..We found substantial variation in RBC glucose relative to extracellular glucose. This in vitro erythrocyte membrane glucose gradient (EMGG) correlated with GG and by inference with a higher risk of complications...
  44. PHOSPHORYLATION & CONTROL OF RED CELL CYTOSKELETON
    MARIANO TAO; Fiscal Year: 1992
    Underlying the human erythrocyte membrane are a group of peripheral proteins which aggregate to form a cytoskeletal network...
  45. STRUCTURE & FUNCTION OF HUMAN RBC MEMBRANE PROTEIN 7.2B
    WILLIAM MENTZER; Fiscal Year: 1993
    ..2b and its topography within the erythrocyte membrane, 2) to evaluate its putative function as a component of an ion channel, and 3) to explore the timing and ..
  46. MAINTENANCE OF LIPID ASYMMETRY IN THE HUMAN ERYTHROCYTE
    Alan Schroit; Fiscal Year: 1999
    ..This proposal focuses on the organization, dynamics and spatial distribution of PS in the erythrocyte membrane and the mechanism by which reticuloendothelial cells recognize aged, PS-expressing cells...
  47. ATP-DEPENDENT SHAPE CHANGE OF THE RED CELL MEMBRANE
    GRANT FAIRBANKS; Fiscal Year: 1990
    ..of ATP-dependent surface contour smoothing in the echinocyte-discocyte transformation of the human erythrocyte membrane. Aspects of this problem will be studied at the level of the intact cell, isolated membrane, inside-out ..
  48. STRUCTURE AND FUNCTION OF RED CELL MEMBRANES
    MARTIN MORRISON; Fiscal Year: 1980
    Our studies of the human erythrocyte membrane proteins will continue to emphasize investigation of the transmembrane proteins...
  49. Mechanisms of Erythrocytic Infection & Anemia in Malaria
    Kasturi Haldar; Fiscal Year: 2009
    ..signaling raft complexes during parasite entry confer susceptibility to malarial infection and alter erythrocyte membrane properties...
  50. STRUCTURAL STUDIES OF THE HUMAN ERYTHROCYTE MEMBRANE
    JOHN BRANDTS; Fiscal Year: 1980
    In a very sensitive scanning calorimeter, five structural transitions of the human erythrocyte membrane can be seen over the temperature range from 45 degrees to 80 degrees centigrade...
  51. HUMAN ERYTHROCYTE MEMBRANE CYTOSKELETON ASSOCIATIONS
    G Bennett; Fiscal Year: 1990
    ..proposal are to a) elucidate in further detail the intermolecular associations of proteins of the human erythrocyte membrane skeleton; b) determine how membrane proteins assemble during erythroid development; c) use the erythrocyte ..
  52. ERYTHROCYTE MEMBRANE ABNORMALITIES IN SICKLE DISEASE
    Robert Hebbel; Fiscal Year: 2002
    ..These studies will rigorously test our hypotheses regarding the participation of TSP and CD36 in mediating sickle RBC adhesion to endothelium. ..
  53. BIOCHEMICAL STUDIES ON ERYTHROCYTE INVASION BY PLASMODIA
    Margaret Perkins; Fiscal Year: 1993
    ..This is particularly intriguing phenomenon, because of the rigid nature of the erythrocyte membrane and its lack of phagocytic or endocytotic ability. The parasite must initiate its entry...
  54. BIOCHEMICAL STUDIES ON ERYTHROCYTE INVASION BY PLASMODIA
    Margaret Perkins; Fiscal Year: 1991
    ..This is particularly intriguing phenomenon, because of the rigid nature of the erythrocyte membrane and its lack of phagocytic or endocytotic ability. The parasite must initiate its entry...
  55. RAMAN SPECTROSCOPY OF ERYTHROCYTE AND MODEL MEMBRANES
    John Kauffman; Fiscal Year: 1980
    ..This inculdes the stepwise removal, addition or alteration or proteins of the human erythrocyte membrane, as well as the systematic study of membrane vesicles, lipid components, model systems, and diseased ..
  56. FUNCTIONS AND MECHANISM OF CELL MEMBRANE ION TRANSPORT
    Edward Johnson; Fiscal Year: 1980
    ..Investigators employ model systems ranging from the synthetic lipid bilayer membrane through the erythrocyte membrane to the complex level of membrane functioning in synthetic preparations of cardiac muscle...
  57. SIGNAL TRANSDUCTION MECHANISMS AND LEAD TOXICITY
    Joseph Bressler; Fiscal Year: 2001
    ..The first long term goal of this study is to determine whether Pb2+ stimulates phosphorylation of erythrocyte membrane proteins by activating PKC...
  58. HOST-PARASITE INTERACTIONS IN MALARIA
    ARAXIE KILEJIAN; Fiscal Year: 1990
    ..The know protein (KP) of Plasmodium falciparum interacts with the host erythrocyte membrane and induces membrane protrusions called knobs...
  59. ENZYMATIC MODIFICATION OF CARBOXYL RESIDUES IN PROTEIN
    Sangduk Kim; Fiscal Year: 1980
    ..by S-adenosylmethionine:protein-carboxyl O-methyltransferase (protein methylase II) and neutralizes erythrocyte membrane proteins...
  60. MEMBRANE DYSFUNCTION IN SCHIZOPHRENIA
    John Rotrosen; Fiscal Year: 1990
    ..The goals of the present study are to document the type and extent of erythrocyte membrane phospholipid abnormalities in diagnostically well-characterized schizophrenic patients and control groups...
  61. Molecular Biology of Erythrocyte Ankyrin
    Patrick G Gallagher; Fiscal Year: 2010
    ..proposal are to elucidate the molecular mechanisms involved in normal and abnormal expression of the human erythrocyte membrane protein ankyrin...
  62. VIRUS PHOTOINACTIVATION--DIMETHYLMETHYLENE BLUE IN RBC
    Stephen Wagner; Fiscal Year: 2004
    ..abstract_text> ..
  63. Diamond-Blackfan Anemia and Ribosomal Protein S19
    MOHANDAS NARLA; Fiscal Year: 2008
    ..Furthermore, it is our hope that the new insights generated by our studies might lead to the development of new therapeutic strategies for the treatment of DBA patients presenting with RPS19 gene mutations. ..
  64. RHEOLOGICAL AND ADHERENCE PROPERTIES OF SICKLE CELLS
    MOHANDAS NARLA; Fiscal Year: 2010
    ..We anticipate that our findings will lead to the identification of useful therapeutic strategies for the effective clinical management of this debilitating human disease. ..