erythrocytes

Summary

Summary: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.

Top Publications

  1. ncbi The pathogenic basis of malaria
    Louis H Miller
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 415:673-9. 2002
  2. pmc A restricted subset of var genes mediates adherence of Plasmodium falciparum-infected erythrocytes to brain endothelial cells
    Marion Avril
    Seattle Biomedical Research Institute, Seattle, WA 98109 5219, USA
    Proc Natl Acad Sci U S A 109:E1782-90. 2012
  3. ncbi Killing me softly - suicidal erythrocyte death
    Elisabeth Lang
    Department of Physiology, University of Tubingen, Germany
    Int J Biochem Cell Biol 44:1236-43. 2012
  4. pmc Comparative genomics of the neglected human malaria parasite Plasmodium vivax
    Jane M Carlton
    The Institute for Genomic Research J Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
    Nature 455:757-63. 2008
  5. ncbi On the cytoadhesion of Plasmodium vivax-infected erythrocytes
    Bruna O Carvalho
    Departamento de Genetica, Evolução e Bioagentes, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Brazil
    J Infect Dis 202:638-47. 2010
  6. ncbi Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake
    Leanne Hodson
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, UK
    Prog Lipid Res 47:348-80. 2008
  7. ncbi Deoxygenation-induced and Ca(2+) dependent phosphatidylserine externalisation in red blood cells from normal individuals and sickle cell patients
    Erwin Weiss
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Cell Calcium 51:51-6. 2012
  8. ncbi p38 MAPK activation and function following osmotic shock of erythrocytes
    Sergios Gatidis
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 28:1279-86. 2011
  9. ncbi Dynamic adhesion of eryptotic erythrocytes to endothelial cells via CXCL16/SR-PSOX
    Oliver Borst
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Am J Physiol Cell Physiol 302:C644-51. 2012
  10. pmc An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration
    G D Turner
    Molecular Parasitology Group, John Radcliffe Hospital, Oxford, UK
    Am J Pathol 145:1057-69. 1994

Research Grants

  1. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2011
  2. Mechanisms of Heme Transport in Macrophages
    CARINE CARINE WHITE; Fiscal Year: 2012
  3. Novel Therapy for Preeclampsia
    James W Larrick; Fiscal Year: 2012
  4. Molecular Biology of Human Erythrocyte Alpha Spectrin
    Patrick G Gallagher; Fiscal Year: 2013
  5. Sphingosine 1-phosphate and cardioprotection
    JOEL SAMUEL KARLINER; Fiscal Year: 2012
  6. Novel Chaperone Mechanism for Platelet Disorder
    Zihai Li; Fiscal Year: 2010
  7. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
  8. Effect of Inducible Antioxidants on Hemoglobin Toxicity
    Raymond F Regan; Fiscal Year: 2010
  9. METABOLIC CONTROL OF SUGAR TRANSPORT
    Anthony Carruthers; Fiscal Year: 2012
  10. Role of Neutrophil-Platelet Interactions in Vascular Occlusive Disorders
    Nauder Faraday; Fiscal Year: 2010

Detail Information

Publications289 found, 100 shown here

  1. ncbi The pathogenic basis of malaria
    Louis H Miller
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 415:673-9. 2002
    ..The inability of many countries to fund expensive campaigns and antimalarial treatment requires these tools to be highly effective and affordable...
  2. pmc A restricted subset of var genes mediates adherence of Plasmodium falciparum-infected erythrocytes to brain endothelial cells
    Marion Avril
    Seattle Biomedical Research Institute, Seattle, WA 98109 5219, USA
    Proc Natl Acad Sci U S A 109:E1782-90. 2012
    ..of Plasmodium falciparum infection, but specific interactions involved in cerebral homing of infected erythrocytes (IEs) are poorly understood. In this study, P...
  3. ncbi Killing me softly - suicidal erythrocyte death
    Elisabeth Lang
    Department of Physiology, University of Tubingen, Germany
    Int J Biochem Cell Biol 44:1236-43. 2012
    Similar to nucleated cells, erythrocytes may undergo suicidal death or eryptosis, which is characterized by cell shrinkage, cell membrane blebbing and cell membrane phospholipid scrambling...
  4. pmc Comparative genomics of the neglected human malaria parasite Plasmodium vivax
    Jane M Carlton
    The Institute for Genomic Research J Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
    Nature 455:757-63. 2008
    ..Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species...
  5. ncbi On the cytoadhesion of Plasmodium vivax-infected erythrocytes
    Bruna O Carvalho
    Departamento de Genetica, Evolução e Bioagentes, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Brazil
    J Infect Dis 202:638-47. 2010
    ..vivax. The increasing number of severe manifestations of P. vivax infections, similar to those observed for severe falciparum malaria, suggests that key pathogenic mechanisms (eg, cytoadherence) might be shared by the 2 parasites...
  6. ncbi Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake
    Leanne Hodson
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, UK
    Prog Lipid Res 47:348-80. 2008
    ..The relationship between plasma lipoprotein concentrations and total plasma fatty acid composition, and the use of fatty acid ratios as indices of enzyme activity are also addressed...
  7. ncbi Deoxygenation-induced and Ca(2+) dependent phosphatidylserine externalisation in red blood cells from normal individuals and sickle cell patients
    Erwin Weiss
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Cell Calcium 51:51-6. 2012
    ..The high affinity component accounted for PS scrambling in ≥2/3rd RBCs. It is likely to be most significant in vivo and may be involved in the pathophysiology of SCD or other conditions involving eryptosis...
  8. ncbi p38 MAPK activation and function following osmotic shock of erythrocytes
    Sergios Gatidis
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 28:1279-86. 2011
    ..Similar to apoptosis of nucleated cells, erythrocytes may undergo suicidal death or eryptosis, which is paralleled by cell shrinkage and cell membrane scrambling ..
  9. ncbi Dynamic adhesion of eryptotic erythrocytes to endothelial cells via CXCL16/SR-PSOX
    Oliver Borst
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Am J Physiol Cell Physiol 302:C644-51. 2012
    Suicidal death of erythrocytes, or eryptosis, is characterized by cell shrinkage and cell membrane scrambling leading to phosphatidylserine exposure at the cell surface...
  10. pmc An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration
    G D Turner
    Molecular Parasitology Group, John Radcliffe Hospital, Oxford, UK
    Am J Pathol 145:1057-69. 1994
    The sequestration of parasitized erythrocytes in the microvasculature of vital organs is central to the pathogenesis of severe Plasmodium falciparum malaria...
  11. ncbi Janus kinase 3 is expressed in erythrocytes, phosphorylated upon energy depletion and involved in the regulation of suicidal erythrocyte death
    Shefalee K Bhavsar
    Department of Physiology, University of Tubingen, Gmelinstrasse 5, Tubingen, Germany
    Cell Physiol Biochem 27:547-56. 2011
    ..JAK3 is activated by phosphorylation. Nothing is known about expression of JAK3 in erythrocytes, which may undergo apoptosis-like cell death (eryptosis) characterized by cell membrane scrambling with ..
  12. ncbi Protein kinase CK1α regulates erythrocyte survival
    Christine Zelenak
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 29:171-80. 2012
    ..Similar to apoptosis of nucleated cells, eryptosis, the suicidal death of erythrocytes, is paralleled by cell shrinkage and cell membrane scrambling with phosphatidylserine exposure at the cell ..
  13. ncbi Sunitinib-sensitive suicidal erythrocyte death
    Nazneen Shaik
    Department of Physiology, University of Tuebingen, Tuebingen, Germany
    Cell Physiol Biochem 30:512-22. 2012
    ..Even though lacking mitochondria and nuclei, critical elements in apoptosis of nucleated cells, erythrocytes may undergo eryptosis, an apoptosis-like suicidal death, characterized by cell shrinkage and cell membrane ..
  14. pmc Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum
    Cecile Crosnier
    Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Nature 480:534-7. 2011
    ..Furthermore, Ok(a-) erythrocytes, which express a basigin variant that has a weaker binding affinity for PfRh5, had reduced invasion ..
  15. ncbi Understanding the mechanisms for metabolism-linked hemolytic toxicity of primaquine against glucose 6-phosphate dehydrogenase deficient human erythrocytes: evaluation of eryptotic pathway
    Shobana Ganesan
    National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, United States
    Toxicology 294:54-60. 2012
    ..The molecular markers for succeeding cascade of events associated with early clearance of the erythrocytes from the circulation were evaluated for understanding the mechanism for hemolytic toxicity of primaquine...
  16. pmc Plasmodium falciparum-infected erythrocytes induce granzyme B by NK cells through expression of host-Hsp70
    Evelyn Böttger
    Institute for Tropical Medicine, Tubingen University, Tubingen, Germany
    PLoS ONE 7:e33774. 2012
    In the early immune response to Plasmodium falciparum-infected erythrocytes (iRBC), Natural Killer (NK) cells are activated, which suggests an important role in innate anti-parasitic immunity...
  17. ncbi Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis
    Erin Wei Qian
    Programme of Biochemistry, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, People s Republic of China
    J Nat Prod 75:531-7. 2012
    ..However, the protective role of 1 in human erythrocytes remains unclear...
  18. pmc α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer
    Bruno Fauvet
    Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Station 19, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    J Biol Chem 287:15345-64. 2012
    ..These results do not rule out the possibility that α-syn becomes structured upon interaction with other proteins and/or biological membranes...
  19. ncbi Altered erythrocyte endothelial adherence and membrane phospholipid asymmetry in hereditary hydrocytosis
    Patrick G Gallagher
    Department of Pediatrics, Yale University School of Medicine, PO Box 208064, 333 Cedar St, New Haven, CT 06520 8064
    Blood 101:4625-7. 2003
    ..b>Erythrocytes from 2 patients with hydrocytosis were studied to gain insight into the mechanism of thrombosis in this ..
  20. ncbi Inhibition of Ca(2+) entry and suicidal erythrocyte death by naringin
    Nazneen Shaik
    Department of Physiology, University of Tuebingen, Tuebingen, Germany
    Cell Physiol Biochem 30:678-86. 2012
    ..Similar to apoptosis of nucleated cells, suicidal death of erythrocytes or eryptosis is paralleled by cell shrinkage and cell membrane scrambling with phosphatidylserine exposure at ..
  21. ncbi The impact of erythrocyte age on eryptosis
    Mehrdad Ghashghaeinia
    Department of Physiology, University of Tubingen, Germany
    Br J Haematol 157:606-14. 2012
    Mature, circulating erythrocytes undergo senescence, which limits their life span to approximately 120 d...
  22. ncbi Proteome analysis of erythrocytes lacking AMP-activated protein kinase reveals a role of PAK2 kinase in eryptosis
    Christine Zelenak
    Department of Physiology, University of Tübingen, Germany
    J Proteome Res 10:1690-7. 2011
    ..b>Erythrocytes lacking AMPK are susceptible to suicidal cell death (eryptosis)...
  23. pmc Induction of strain-transcending antibodies against Group A PfEMP1 surface antigens from virulent malaria parasites
    Ashfaq Ghumra
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Pathog 8:e1002665. 2012
    ..in rabbits against the N-terminal domains showed functional activity (surface reactivity with live infected erythrocytes (IEs), rosette inhibition and induction of phagocytosis of IEs) down to low concentrations (<10 µg/ml of ..
  24. ncbi Enhanced erythrocyte membrane exposure of phosphatidylserine following sorafenib treatment: an in vivo and in vitro study
    Adrian Lupescu
    Department of Physiology, Tuebingen, Tubingen, Germany
    Cell Physiol Biochem 30:876-88. 2012
    ..Hematological side effects of Nexavar(®) chemotherapy include anemia. Erythrocytes may undergo apoptosis-like suicidal death or eryptosis, which is characterized by cell shrinkage and ..
  25. ncbi Mechanisms of uremic erythrocyte-induced adhesion of human monocytes to cultured endothelial cells
    Assunta Pandolfi
    Department of Biomorphology, University G D Annunzio, Aging Research Center, Ce S I, G d Annunzio University Foundation, Chieti Pescara, Italy
    J Cell Physiol 213:699-709. 2007
    ..disease (ESRD) endothelium may represent a key target for the action of circulating elements, such as modified erythrocytes (RBC) and/or plasmatic factors, that may facilitate inflammation and the vasculopathy associated with uremia...
  26. ncbi Inhibitory effect of furosemide on non-selective voltage-independent cation channels in human erythrocytes
    Yuliya V Kucherenko
    Department of Physiology Institute I, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Cell Physiol Biochem 30:863-75. 2012
    ..cotransporter, has been shown to decrease cytosolic Ca(2+) concentration ([Ca(2+)](i)) in platelets and erythrocytes. [Ca(2+)](i) in erythrocytes is a function of Ca(2+) permeable cation channels. Activation of those channels e...
  27. ncbi Tanshinone IIA stimulates erythrocyte phosphatidylserine exposure
    Christine Zelenak
    Department of Physiology, University of Tuebingen, Tuebingen, Germany
    Cell Physiol Biochem 30:282-94. 2012
    ..Tanshinone IIA is effective in part through mitochondrial depolarization and altered gene expression. Erythrocytes lack mitochondria and nuclei but may undergo eryptosis, an apoptosis-like suicidal cell death characterized by ..
  28. pmc Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity
    Jo Anne Chan
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    J Clin Invest 122:3227-38. 2012
    ..During parasitic development, P. falciparum-infected erythrocytes (P...
  29. ncbi Polyphyllin D induces apoptosis in human erythrocytes through Ca²⁺ rise and membrane permeabilization
    Minghui Gao
    Programme of Biochemistry, School of Life Sciences, The Chinese University of Hong Kong, Room 514, Basic Medical Sciences Building, Shatin, NT, Hong Kong, China
    Arch Toxicol 86:741-52. 2012
    ..However, the effect of PD on the induction of cell death in human erythrocytes remains unknown...
  30. pmc Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications
    J Alexandra Rowe
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, University of Edinburgh, UK
    Expert Rev Mol Med 11:e16. 2009
    ..Adhesion of erythrocytes infected with Plasmodium falciparum to human cells has a key role in the pathogenesis of life-threatening ..
  31. ncbi Carbon monoxide-sensitive apoptotic death of erythrocytes
    Elisabeth Lang
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Basic Clin Pharmacol Toxicol 111:348-55. 2012
    ..CORM-2 is at least partially effective by modifying gene expression and mitochondrial potential. Erythrocytes lack nuclei and mitochondria but may undergo suicidal cell death or eryptosis, characterized by cell shrinkage ..
  32. ncbi Differential erythropoietin action upon cells induced to eryptosis by different agents
    Daiana M Vota
    Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IQUIBICEN CONICET Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
    Cell Biochem Biophys 65:145-57. 2013
    Eryptosis is a process by which mature erythrocytes can undergo self-destruction sharing several features with apoptosis. Premature programmed erythrocyte death may be induced by different agents...
  33. ncbi Sphingomyelinase-induced adhesion of eryptotic erythrocytes to endothelial cells
    Majed Abed
    Physiologisches Institut, Eberhard Karls Universitat Tubingen, Gmelinstr 5, D 72076 Tubingen, Germany
    Am J Physiol Cell Physiol 303:C991-9. 2012
    ..Eryptotic erythrocytes adhere to the vascular wall by binding of phosphatidylserine to the CXC chemokine ligand 16 (CXCL16)...
  34. ncbi Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank
    G Michael Felker
    Duke Clinical Research Institute, Durham, North Carolina, USA
    J Am Coll Cardiol 50:40-7. 2007
    ..The goal of this study was to identify potentially novel laboratory markers of risk in chronic heart failure patients...
  35. ncbi Enhanced apoptotic death of erythrocytes induced by the mycotoxin ochratoxin A
    Kashif Jilani
    Department of Physiology, University of Tuebingen, Gmelinstraße 5, 72076 Tuebingen, Germany
    Kidney Blood Press Res 36:107-18. 2012
    ..Sequelae of ochratoxin intoxication include anemia. Similar to apoptosis of nucleated cells, erythrocytes may undergo suicidal cell death or eryptosis, which is characterized by cell shrinkage and cell membrane ..
  36. pmc Investigating the host binding signature on the Plasmodium falciparum PfEMP1 protein family
    Joel H Janes
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 7:e1002032. 2011
    ..falciparum infected erythrocytes. PfEMP1 proteins/var genes are classified into three main subfamilies (UpsA, UpsB, and UpsC) that are ..
  37. ncbi Super-resolution dissection of coordinated events during malaria parasite invasion of the human erythrocyte
    David T Riglar
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia
    Cell Host Microbe 9:9-20. 2011
    ..The ability to break down each molecular step allows us to propose a comprehensive model for the molecular basis of parasite invasion...
  38. pmc The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody
    Alexander D Douglas
    Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
    Nat Commun 2:601. 2011
    ..falciparum is a degenerate process involving a series of parallel redundant pathways...
  39. pmc Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2
    Arjen M Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Med 2:e204. 2005
    In falciparum malaria sequestration of erythrocytes containing mature forms of Plasmodium falciparum in the microvasculature of vital organs is central to pathology, but quantitation of this hidden sequestered parasite load in vivo has ..
  40. ncbi In vitro effect of CTAB- and PEG-coated gold nanorods on the induction of eryptosis/erythroptosis in human erythrocytes
    Irene P Lau
    Programme of Biochemistry, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Nanotoxicology 6:847-56. 2012
    ..Au-NRs (15 nM × 64 nM) coated with CTAB (cetyltrimethylammonium bromide) or PEG (polyethylene glycol) in human erythrocytes on the induction of haemolysis and erythroptosis...
  41. ncbi Participation of leukotriene C(4) in the regulation of suicidal erythrocyte death
    M Foller
    Department of Physiology, University of Tubingen, Germany
    J Physiol Pharmacol 60:135-43. 2009
    Eryptosis, the suicidal death of erythrocytes, is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine exposure at the erythrocyte surface...
  42. pmc Structural basis for the ABO blood-group dependence of Plasmodium falciparum rosetting
    Inès Vigan-Womas
    Institut Pasteur, Unité d Immunologie Moléculaire des Parasites, Paris, France
    PLoS Pathog 8:e1002781. 2012
    ....
  43. pmc Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites
    Dave Richard
    Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria 3052, Australia
    J Biol Chem 285:14815-22. 2010
    ..We propose that the formation of the AMA1-RON complex is essential for secretion of the rhoptry contents, which then allows the establishment of parasite infection within the parasitophorous vacuole...
  44. ncbi Eryptosis and oxidative damage in type 2 diabetic mellitus patients with chronic kidney disease
    J V Calderón-Salinas
    Departamento de Bioquimica, Centro de Investigacion y Estudios Avanzados, Mexico City, Mexico
    Mol Cell Biochem 357:171-9. 2011
    ..complications of type 2 diabetes mellitus (T2DM) include retinopathy, atherosclerosis, shortened life span of erythrocytes, nephropathy, and chronic kidney disease (CKD)...
  45. ncbi Stimulation of suicidal erythrocyte death by benzethonium
    Elisabeth Lang
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 28:347-54. 2011
    ..Even though lacking mitochondria, erythrocytes may similarly undergo suicidal cell death or eryptosis...
  46. pmc New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq
    Thomas D Otto
    Parasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Mol Microbiol 76:12-24. 2010
    ..These data reveal new features of the P. falciparum transcriptional landscape and significantly advance our understanding of the parasite's red blood cell-stage transcriptome...
  47. ncbi Immune effector mechanisms in malaria
    K Marsh
    KEMRI Centre for Geographic Medicine Research Coast CGMRC, PO Box 230, Kilifi, Kenya
    Parasite Immunol 28:51-60. 2006
    ....
  48. pmc Plasmodium vivax clinical malaria is commonly observed in Duffy-negative Malagasy people
    Didier Menard
    Institut Pasteur de Madagascar, Unité de Recherche sur le Paludisme, Antananarivo 101, Madagascar
    Proc Natl Acad Sci U S A 107:5967-71. 2010
    ..cytometry and adsorption-elution results confirmed the absence of Duffy antigen expression on Duffy-negative erythrocytes. P. vivax PCR positivity was observed in 8.8% (42/476) of asymptomatic Duffy-negative people...
  49. pmc Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasites
    Shailja Singh
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    PLoS Pathog 6:e1000746. 2010
    The invasion of erythrocytes by Plasmodium merozoites requires specific interactions between host receptors and parasite ligands...
  50. pmc Plasmodium falciparum-infected erythrocytes induce NF-kappaB regulated inflammatory pathways in human cerebral endothelium
    Abhai K Tripathi
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Blood 114:4243-52. 2009
    ..Cerebral malaria is a severe multifactorial condition associated with the interaction of high numbers of infected erythrocytes to human brain endothelium without invasion into the brain...
  51. ncbi Withaferin A-stimulated Ca2+ entry, ceramide formation and suicidal death of erythrocytes
    Kashif Jilani
    Department of Physiology, University of Tuebingen, Gmelinstraße 5, 72076 Tuebingen, Germany
    Toxicol In Vitro 27:52-8. 2013
    ..b>Erythrocytes lack mitochondria and nuclei but may enter apoptosis-like eryptosis, a suicidal cell death characterized by ..
  52. ncbi Stimulation of suicidal death of erythrocytes by rifampicin
    Majed Abed
    Department of Physiology, University of Tuebingen, Tuebingen, Germany
    Toxicology 302:123-8. 2012
    ..Side effects of rifampicin include hemolytic anemia. Loss of circulating erythrocytes resembling hemolytic anemia could result from stimulation of eryptosis, the suicidal erythrocyte death ..
  53. ncbi Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum
    Wai Hong Tham
    Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Vic, Australia
    Trends Parasitol 28:23-30. 2012
    ....
  54. pmc Increased caspase-3 immunoreactivity of erythrocytes in STZ diabetic rats
    Ugur Firat
    Department of Pathology, School of Medicine, Dicle University, Diyarbakır 21000, Turkey
    Exp Diabetes Res 2012:316384. 2012
    Eryptosis is a term to define apoptosis of erythrocytes. Oxidative stress and hyperglycemia, both of which exist in the diabetic intravascular environment, can trigger eryptosis of erythrocytes...
  55. pmc Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion
    Prakash Srinivasan
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 108:13275-80. 2011
    ..Collectively, these results identify the binding of RON2 to the hydrophobic pocket of AMA1 as the step that commits Plasmodium merozoites to RBC invasion and point to RON2 as a potential vaccine candidate...
  56. ncbi Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
    Kenyatta Cosby
    Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 7B15 Bethesda, Maryland 20892, USA
    Nat Med 9:1498-505. 2003
    ..gas and NO-modified hemoglobin resulted from the nitrite reductase activity of deoxyhemoglobin and deoxygenated erythrocytes. This finding links tissue hypoxia, hemoglobin allostery and nitrite bioactivation...
  57. ncbi Relation between red cell distribution width and clinical outcomes after acute myocardial infarction
    Saleem Dabbah
    Department of Cardiology, Rambam Medical Center, and the Bruce Rappaport Faculty of Medicine and Research Institute, Technion, Israel Institute of Technology, Haifa, Israel
    Am J Cardiol 105:312-7. 2010
    ..In conclusion, there is a graded, independent association between increased RDW and mortality after AMI. An increase in RDW during hospitalization also portends adverse clinical outcome...
  58. pmc Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening
    Martin Smilkstein
    Medical Research Service, Department of Veterans Affairs Medical Center, Oregon Health and Science University, Portland, Oregon, USA
    Antimicrob Agents Chemother 48:1803-6. 2004
    ..The results obtained with this new fluorescence assay suggest that it may be an ideal method for high-throughput antimalarial drug screening...
  59. ncbi Malaria in pregnancy: pathogenesis and immunity
    Stephen J Rogerson
    Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Lancet Infect Dis 7:105-17. 2007
    ..of the biological basis for susceptibility to malaria in pregnancy was recently advanced by the discovery that erythrocytes infected with Plasmodium falciparum accumulate in the placenta through adhesion to molecules such as ..
  60. ncbi The future for blood-stage vaccines against malaria
    Jack S Richards
    Infection and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 87:377-90. 2009
    ..Additionally, objective criteria and approaches are needed to prioritize the large number of candidate antigens, and strong candidates need to be tested in clinical trials as quickly as possible...
  61. pmc Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria
    P C Bull
    Kenya Medical Research Institute CRC, Kilifi Unit
    Nat Med 4:358-60. 1998
    ..prospective study of Kenyan children, we have used the fact that anti-PfEMP1 antibodies agglutinate infected erythrocytes in a variant-specific manner, to show that the PfEMP1 variants expressed during episodes of clinical malaria ..
  62. pmc Reticulocyte and erythrocyte binding-like proteins function cooperatively in invasion of human erythrocytes by malaria parasites
    Sash Lopaticki
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Infect Immun 79:1107-17. 2011
    Plasmodium falciparum causes the most severe form of malaria in humans and invades erythrocytes using multiple ligand-receptor interactions...
  63. ncbi Mechanisms and significance of eryptosis, the suicidal death of erythrocytes
    Florian Lang
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Blood Purif 33:125-30. 2012
    Eryptosis, the suicidal death of erythrocytes, is characterized by erythrocyte shrinkage, blebbing, and phospholipid scrambling of the cell membrane...
  64. pmc Pannexin 1 in erythrocytes: function without a gap
    Silviu Locovei
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, P O Box 016430, Miami, FL 33101, USA
    Proc Natl Acad Sci U S A 103:7655-9. 2006
    ..b>Erythrocytes release ATP in response to low oxygen or to shear stress...
  65. pmc Soft X-ray microscopy analysis of cell volume and hemoglobin content in erythrocytes infected with asexual and sexual stages of Plasmodium falciparum
    Eric Hanssen
    Electron Microscopy Unit, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia
    J Struct Biol 177:224-32. 2012
    ..the most virulent agent of human malaria, undergoes both asexual cycling and sexual differentiation inside erythrocytes. As the intraerythrocytic parasite develops it increases in size and alters the permeability of the host cell ..
  66. ncbi Sphingosine but not sphingosine-1-phosphate stimulates suicidal erythrocyte death
    Syed M Qadri
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 28:339-46. 2011
    ..b>Erythrocytes lack sphingosine phosphate-degrading enzymes and thus store large quantities of sphingosine phosphate...
  67. pmc Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum
    Christopher J Tonkin
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    PLoS Biol 7:e84. 2009
    Cytoadherance of Plasmodium falciparum-infected erythrocytes in the brain, organs and peripheral microvasculature is linked to morbidity and mortality associated with severe malaria. Parasite-derived P...
  68. pmc var gene transcription and PfEMP1 expression in the rosetting and cytoadhesive Plasmodium falciparum clone FCR3S1.2
    Letusa Albrecht
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Box 280, SE 171 77 Stockholm, Sweden
    Malar J 10:17. 2011
    ..Binding of the pRBC is mediated by Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), a large multi-variant molecule encoded by a family of ≈60 var genes...
  69. pmc A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes
    Jeffrey D Dvorin
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 328:910-2. 2010
    Clinical malaria is associated with the proliferation of Plasmodium parasites in human erythrocytes. The coordinated processes of parasite egress from and invasion into erythrocytes are rapid and tightly regulated...
  70. pmc A multifunctional serine protease primes the malaria parasite for red blood cell invasion
    Konstantinos Koussis
    Division of Parasitology, National Institute for Medical Research, London, UK
    EMBO J 28:725-35. 2009
    ..Rupture of the host cell allows release (egress) of daughter merozoites, which invade fresh erythrocytes. We previously showed that a subtilisin-like protease called PfSUB1 regulates egress by being discharged into ..
  71. ncbi Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes
    Sharon Yeoh
    Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Cell 131:1072-83. 2007
    ..vacuole until rupture of the vacuole and host-cell membranes releases merozoites that invade fresh erythrocytes to repeat the cycle...
  72. ncbi Cellular architecture of Plasmodium falciparum-infected erythrocytes
    Eric Hanssen
    Department of Biochemistry and Centre of Excellence for Coherent X ray Science, La Trobe University, Melbourne, VIC 3086, Australia
    Int J Parasitol 40:1127-35. 2010
    ..The particular virulence of this parasite derives from its ability to develop within the erythrocytes of its host and to subvert their function...
  73. pmc Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development
    Michelle J Boyle
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 107:14378-83. 2010
    ..These findings have important implications for defining invasion events and molecular interactions, understanding immune interactions, and identifying and evaluating inhibitors to advance vaccine and drug development...
  74. ncbi Cytotoxicity of graphene oxide and graphene in human erythrocytes and skin fibroblasts
    Ken Hsuan Liao
    Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, United States
    ACS Appl Mater Interfaces 3:2607-15. 2011
    ..Clearly, the toxicity of graphene and graphene oxide depends on the exposure environment (i.e., whether or not aggregation occurs) and mode of interaction with cells (i.e., suspension versus adherent cell types)...
  75. ncbi Moving in and renovating: exporting proteins from Plasmodium into host erythrocytes
    Daniel E Goldberg
    Howard Hughes Medical Institute, Washington University School of Medicine, Department of Medicine, St Louis, Missouri 63110, USA
    Nat Rev Microbiol 8:617-21. 2010
    Malaria parasites live within erythrocytes in the host bloodstream and induce crucial changes to these cells...
  76. pmc Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor
    Alfredo Mayor
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 6:e19422. 2011
    Severe malaria has been attributed partly to the sequestration of Plasmodium falciparum-infected erythrocytes (IEs) in the microvasculature of vital host organs. Identification of P...
  77. pmc The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology
    Pierre A Buffet
    Inserm UPMC, Paris 6 University, UMRs945, Paris, France
    Blood 117:381-92. 2011
    ..This analysis of the RBC-spleen dynamic interactions during P falciparum infection reflects both data and hypotheses, and provides a framework on which a more complete immunologic understanding of malaria pathogenesis may be elaborated...
  78. pmc Surface co-expression of two different PfEMP1 antigens on single plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1
    Louise Joergensen
    Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    PLoS Pathog 6:e1001083. 2010
    ..falciparum erythrocyte membrane protein 1 (PfEMP1) antigens play a major role in cytoadhesion of infected erythrocytes (IE), antigenic variation, and immunity to malaria...
  79. pmc Variation in use of erythrocyte invasion pathways by Plasmodium falciparum mediates evasion of human inhibitory antibodies
    Kristina E M Persson
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Clin Invest 118:342-51. 2008
    Antibodies that inhibit Plasmodium falciparum invasion of erythrocytes are believed to be an important component of immunity against malaria. During blood-stage infection, P...
  80. ncbi Maurer's clefts: a novel multi-functional organelle in the cytoplasm of Plasmodium falciparum-infected erythrocytes
    Michael Lanzer
    Abteilung Parasitologie, Hygiene Institut, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    Int J Parasitol 36:23-36. 2006
    ..1902 by Georg Maurer as a peculiar dotted staining pattern observable by light microscopy in the cytoplasm of erythrocytes infected with the human malarial parasite Plasmodium falciparum, the function of Maurer's clefts have remained ..
  81. ncbi Plasmodium falciparum erythrocyte invasion: a conserved myosin associated complex
    Matthew L Jones
    Division of Geographic Medicine, Department of Medicine, 845 19th St South, BBRB 567, Birmingham, AL 35294, USA
    Mol Biochem Parasitol 147:74-84. 2006
    ..P. falciparum is known to use multiple alternative invasion pathways to enter erythrocytes, hampering vaccine development efforts targeting erythrocyte invasion...
  82. pmc Genesis of and trafficking to the Maurer's clefts of Plasmodium falciparum-infected erythrocytes
    Cornelia Spycher
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Socinstrasse 57, CH 4002 Basel, Switzerland
    Mol Cell Biol 26:4074-85. 2006
    ..We have generated Plasmodium falciparum-infected erythrocytes expressing green fluorescent protein (GFP) chimeras of a Maurer's cleft resident protein, the membrane-..
  83. pmc Branched tricarboxylic acid metabolism in Plasmodium falciparum
    Kellen L Olszewski
    Department of Molecular Biology and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Nature 466:774-8. 2010
    ..These results significantly clarify our understanding of the Plasmodium metabolic network and highlight the ability of altered variants of central carbon metabolism to arise in response to unique environments...
  84. pmc Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes
    Alexander G Maier
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Cell 134:48-61. 2008
    ..gene knockout strategy combined with functional screens to identify proteins exported into parasite-infected erythrocytes and involved in remodeling these cells...
  85. ncbi Malaria parasite proteins that remodel the host erythrocyte
    Alexander G Maier
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria, Australia
    Nat Rev Microbiol 7:341-54. 2009
    ..falciparum-infected erythrocytes and has provided us with insights into the functions of the parasite protein exportome...
  86. pmc The Trw type IV secretion system of Bartonella mediates host-specific adhesion to erythrocytes
    Muriel Vayssier-Taussat
    Unité Sous Contrat Bartonella, INRA, Maisons Alfort, France
    PLoS Pathog 6:e1000946. 2010
    ..and rat-specific Bartonella tribocorum, we established in vitro adhesion and invasion assays with isolated erythrocytes that fully reproduce the host-specificity of erythrocyte infection as observed in vivo...
  87. pmc Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition
    Alexandre Juillerat
    Institut Pasteur, Unité d Immunologie Structurale, 75015 Paris, France
    Proc Natl Acad Sci U S A 108:5243-8. 2011
    ..The specific interaction observed with heparin opens the way for developing antirosetting therapeutic strategies...
  88. pmc Reduced CD36-dependent tissue sequestration of Plasmodium-infected erythrocytes is detrimental to malaria parasite growth in vivo
    Jannik Fonager
    Leiden Malaria Research Group, Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands
    J Exp Med 209:93-107. 2012
    ..These results reveal for the first time the importance of sequestration to a malaria infection, with implications for the development of strategies aimed at reducing pathology by inhibiting tissue sequestration...
  89. pmc Targeting sialic acid dependent and independent pathways of invasion in Plasmodium falciparum
    Rosalynn Louise Ord
    Department of Blood Borne Parasites, New York Blood Center, New York, New York, United States of America
    PLoS ONE 7:e30251. 2012
    ..Results obtained show promise for the potential use of such hybrid vaccines to induce antibodies that can block multiple parasite ligand-red cell receptor interactions and thus inhibit parasite invasion...
  90. ncbi Innate immune response to malaria: rapid induction of IFN-gamma from human NK cells by live Plasmodium falciparum-infected erythrocytes
    Katerina Artavanis-Tsakonas
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Immunol 169:2956-63. 2002
    ..falciparum schizonts. Infected erythrocytes induce a more rapid and intense IFN-gamma response from malaria-naive PBMC than do P...
  91. pmc Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration
    Blandine Franke-Fayard
    Department of Parasitology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 102:11468-73. 2005
    Sequestration of malaria-parasite-infected erythrocytes in the microvasculature of organs is thought to be a significant cause of pathology...
  92. ncbi Parasite adaptations to within-host competition
    Nicole Mideo
    Department of Biology, Queen s University, Kingston, ON K7L 3N6, Canada
    Trends Parasitol 25:261-8. 2009
    ..A better understanding of parasite adaptations to competitive interactions will have important public health implications...
  93. ncbi Hemoglobins S and C interfere with actin remodeling in Plasmodium falciparum-infected erythrocytes
    Marek Cyrklaff
    Department of Infectious Diseases, Parasitology, Heidelberg University, 69120 Heidelberg, Germany
    Science 334:1283-6. 2011
    ..affected the trafficking system that directs parasite-encoded proteins to the surface of infected erythrocytes. Cryoelectron tomography revealed that the parasite generated a host-derived actin cytoskeleton within the ..
  94. ncbi A large focus of naturally acquired Plasmodium knowlesi infections in human beings
    Balbir Singh
    Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kuching, Sarawak, Malaysia
    Lancet 363:1017-24. 2004
    ..We aimed to investigate whether such infections could be attributable to a variant form of P malariae or a newly emergent Plasmodium species...
  95. ncbi Reticulocyte-binding protein homologue 5 - an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum
    Jake Baum
    Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Vic, Australia
    Int J Parasitol 39:371-80. 2009
    Invasion of erythrocytes is a prerequisite in the life history of the malaria parasite...
  96. ncbi Cross-talk between T cells and NK cells generates rapid effector responses to Plasmodium falciparum-infected erythrocytes
    Amir Horowitz
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Immunol 184:6043-52. 2010
    ....
  97. ncbi Plasmodium falciparum culture: the benefits of shaking
    Richard J W Allen
    The Australian National University, Canberra, Australia
    Mol Biochem Parasitol 169:63-5. 2010
    ..In addition, we show that under continuous suspension, the time taken for genetically altered parasites to re-populate cultures post-transfection is dramatically reduced...
  98. ncbi P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1
    J A Rowe
    Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA
    Nature 388:292-5. 1997
    ..Studies in Africa have shown that severe malaria is associated with the ability of erythrocytes infected with the parasite Plasmodium falciparum to bind uninfected erythrocytes and form rosettes...
  99. pmc An adaptable two-color flow cytometric assay to quantitate the invasion of erythrocytes by Plasmodium falciparum parasites
    Michel Theron
    Sanger Malaria Programme, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
    Cytometry A 77:1067-74. 2010
    ..Invasion of human erythrocytes by Plasmodium falciparum is a phenotype of particular interest because of its central role in parasite ..
  100. ncbi Whole cell imaging reveals novel modular features of the exomembrane system of the malaria parasite, Plasmodium falciparum
    Eric Hanssen
    Department of Biochemistry and Center of Excellence for Coherent X ray Science, La Trobe University, Melbourne, VIC 3086, Australia
    Int J Parasitol 40:123-34. 2010
    ..We have used two whole cell imaging modalities to explore the topography of parasitised erythrocytes. Three-dimensional structured illumination microscopy provides resolution beyond the optical diffraction limit ..
  101. pmc H2A.Z demarcates intergenic regions of the plasmodium falciparum epigenome that are dynamically marked by H3K9ac and H3K4me3
    Richard Bartfai
    Department of Molecular Biology, Radboud University, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    PLoS Pathog 6:e1001223. 2010
    ..Furthermore, our findings place H2A.Z at the cradle of P. falciparum epigenetic regulation by stably defining intergenic regions and providing a platform for dynamic assembly of epigenetic and other transcription related complexes...

Research Grants72

  1. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2011
    ..levels of endothelin-1 (ET-1), low red cell Mg2+ levels, and increased K+ efflux may all contribute to sickle erythrocytes (SRBC) abnormal physiology...
  2. Mechanisms of Heme Transport in Macrophages
    CARINE CARINE WHITE; Fiscal Year: 2012
    ..e. erythrophagocytosis), and proteolytic degradation of hemoglobin. How heme is extracted from senescent erythrocytes and transported across the M&phagolysosomal membrane is unknown...
  3. Novel Therapy for Preeclampsia
    James W Larrick; Fiscal Year: 2012
    ..Digibind has been shown to reverse inhibition of the NKA in erythrocytes from patients with PE...
  4. Molecular Biology of Human Erythrocyte Alpha Spectrin
    Patrick G Gallagher; Fiscal Year: 2013
    ..important information about the structure, function, and regulation of the ?-spectrin gene in normal and mutant erythrocytes. Nucleotide sequence analysis of amplified patient genomic DNA will be performed to identify genetic defects in ..
  5. Sphingosine 1-phosphate and cardioprotection
    JOEL SAMUEL KARLINER; Fiscal Year: 2012
    ..S1P is a lysophospholipid produced by mast cells, erythrocytes, platelets, cardiac myocytes, and other cell types in de novo biosynthetic pathways and by metabolism of the ..
  6. Novel Chaperone Mechanism for Platelet Disorder
    Zihai Li; Fiscal Year: 2010
    ..Research and specific Challenge Topic, 04-HL-103, "Assess the role of leukocyte interaction with platelets, erythrocytes, and endothelium in the pathogenesis of heart, lung, and blood diseases"...
  7. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
    ..Research and specific Challenge topic, 04- HL-103: Assess the role of leukocyte interaction with platelets, erythrocytes, and endothelium in the pathogenesis of heart, lung, and blood diseases...
  8. Effect of Inducible Antioxidants on Hemoglobin Toxicity
    Raymond F Regan; Fiscal Year: 2010
    ..A growing body of evidence suggests that hemoglobin (Hb) release from lysing erythrocytes may contribute to oxidative injury to tissue surrounding a hematoma...
  9. METABOLIC CONTROL OF SUGAR TRANSPORT
    Anthony Carruthers; Fiscal Year: 2012
    Abstract Glucose uptake in astrocytes, basal cardiomyocytes, endothelial cells, erythrocytes and smooth muscle is mediated by GLUT1...
  10. Role of Neutrophil-Platelet Interactions in Vascular Occlusive Disorders
    Nauder Faraday; Fiscal Year: 2010
    ..Research and specific Challenge Topic (04-HL- 103): Assess the role of leukocyte interactions with platelets, erythrocytes, and endothelium in the pathogenesis of heart, lung, and blood diseases...
  11. Adhesion Mechanisms Mediating Sickle Cell Vasooclusion In Vivo
    Paul S Frenette; Fiscal Year: 2013
    ..adherent leukocytes recruited in inflamed venules, played a direct role in VOC by interacting with circulating erythrocytes (RBC)...
  12. High Efficiency Microfluidic Purification of Stem Cells to Improve Transplants
    James C Sturm; Fiscal Year: 2012
    ..Because erythrocytes increase both the risk of harmful side effects in transplant patients and the cost of cryopreservation, they ..
  13. New Pathways in Thrombosis and Inflammation Mediated by Semaphorin-Plexin Signali
    Guy A Zimmerman; Fiscal Year: 2010
    ..Research, and specific Challenge Topic 04-HL-103: assess the role of leukocyte interaction with platelets, erythrocytes, and endothelium in the pathogenesis of heart, lung, and blood diseases...
  14. Quercetin to enhance the bioavailability and activity of green tea polyphenols
    SUSANNE MARGARETE HENNING; Fiscal Year: 2013
    ..and global DNA methylation will be determined in tumor and normal prostate tissue and COMT activity in erythrocytes using HPLC-ECD, real time qPCR and Western blot analyses...
  15. Role of Protective and Pathogenic B cells in Modulating Pediatric Severe Malaria
    Tom Were; Fiscal Year: 2013
    ..and multi-factorial and has been attributed to direct and indirect destruction of infected and uninfected erythrocytes, suppression of erythropoiesis, erythrophagocytosis, and dysregulation in cytokine production...
  16. Arginine, Nitric Oxide, and Severe Malaria
    JOE BRICE WEINBERG; Fiscal Year: 2012
    ..can modulate endothelial function (reduction of cell adhesion molecule expression and adherence of parasitized erythrocytes). Arginine can be converted to citrulline and NO by NOS, and to ornithine and urea by arginase...
  17. Molecular Genetics of Sideroblastic Anemia
    Mark D Fleming; Fiscal Year: 2013
    ..The vast majority of iron in mammals is present as heme, primarily in hemoglobin in erythrocytes, underscoring the importance of understanding mitochondrial iron utilization to describing the normal pathways ..
  18. Endogenous Hemoglobin And Heme Detoxification After Intracerebral Hemorrhage
    Xiurong Zhao; Fiscal Year: 2013
    ..After ICH, the cell-free Hb and heme released from erythrocytes are first bound to haptoglobin (Hp) and hemopexin (Hx), forming stable Hb-Hp and heme-Hx complexes which are ..
  19. Mechanisms of Brain Injury after Intraventricular Hemorrhage
    Guohua Xi; Fiscal Year: 2013
    ..However, the mechanisms of IVH-induced hydrocephalus are not well understood. Lysis of erythrocytes results in iron accumulation in the brain and causes brain damage after intracerebral hemorrhage...
  20. Regulation of stem cell fate by protein degradation
    Andre Catic; Fiscal Year: 2013
    ..in the blood, where millions of cells are lost every day and stem and progenitor cells tirelessly produce erythrocytes, thrombocytes, myelocytes, and lymphocytes...
  21. Microparticles as Messengers of Communication Between Blood and Vascular Cells
    Richard P Phipps; Fiscal Year: 2010
    ..specifically to the NHLBI Challenge Topic 04-HL-103: "Assess the role of leukocyte interaction with platelets, erythrocytes, and endothelium in the pathogenesis of heart, lung, and blood diseases...
  22. Purine Pathways and Inhibitor Design in Plasmodium
    Vern L Schramm; Fiscal Year: 2012
    ..P. falciparum is a purine auxotroph, requiring purine salvage from human erythrocytes for survival. Using the frontier technology of transition state analysis, the transition state structures of P...
  23. Inhibition of platelet-leukocyte interactions to treat TRALI
    Paul S Frenette; Fiscal Year: 2010
    ..Research, and the specific Challenge Topic 04-HL-103 Assess the role of leukocyte interaction with platelets, erythrocytes, and endothelium in the pathogenesis of heart, lung, and blood diseases...
  24. Endogenous Oxalate Synthesis
    Ross P Holmes; Fiscal Year: 2013
    ..It is hypothesized that reducing this system will increase oxalate synthesis. Human erythrocytes and those from Glyoxalase-1 (GLO-1) deficient and wild type mice will be exposed to glyoxal, glutathione ..
  25. The role of erythroferrone in iron homeostasis and in iron-loading anemias
    Tomas Ganz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The production of erythrocytes depends on the timely delivery of sufficient iron to erythroid precursors...
  26. Bordetella adenylate cyclase toxin: the role of cell interaction in toxin functio
    JOSHUA CLARK EBY; Fiscal Year: 2013
    ..will enhance the other major function of the toxin, formation of oligomeric pores which cause lysis of erythrocytes and contribute to non-apoptotic cell death of macrophages...
  27. Prevalence of environmental and genetic risk factors for gastric cancer in a popu
    LOVELL ALLAN JONES; Fiscal Year: 2011
    ..We will analyze the levels of folate in the erythrocytes and the homocysteine in the plasma of the children participants as intermediate biomarkers for GC risk since ..
  28. ROLE OF COMPLEMENT RECEPTOR 1 IN ERYTHROCYTE INVASION BY PLASMODIUM FALCIPARUM IN
    GORDON AKANZUWINE AWANDARE; Fiscal Year: 2013
    ..However, some P. falciparum strains have the ability to invade neuraminidase-treated erythrocytes which lack SA, demonstrating the existence of alternative SA-independent invasion mechanisms...
  29. Functional genomic analysis of host determinants of malaria infection
    Elizabeth Egan; Fiscal Year: 2013
    ..All of the clinical symptoms of malaria are attributable to the stage of infection when parasites reside within erythrocytes. Since these cells are enucleated, they represent an attractive target for host-directed therapeutics, as they ..
  30. P.falciparum var gene diversity and malaria control
    KAREN PATRICIA DAY; Fiscal Year: 2013
    ..falciparum Erythrocyte Membrane Protein-1 (PfEMP1), a molecule that is expressed on the surface of erythrocytes infected by asexual parasite stages and transmission stages. There are 50-60 var genes in a P...
  31. Rac1 and Rac2 Guanosine Triphosphatases in Erythroid Function and Differentiation
    THEODOSIA ANASTASIOS KALFA; Fiscal Year: 2012
    ..However their role in erythroid precursors and erythrocytes has not been evaluated...
  32. The Plasmodium 2TM and PHIST protein families
    Thomas J Templeton; Fiscal Year: 2012
    ..of ion channels prompted us to consider that they might encode the new permeability pathways (NPPs) of infected erythrocytes. We propose here to test this hypothesis using genetically manipulated parasite lines that either dominantly ..
  33. Myosin Functions in the Enterocyte
    Mark S Mooseker; Fiscal Year: 2012
    ..Myo9b knock out (KO) mice under unstressed conditions exhibit hallmark symptoms of IBD including presence of erythrocytes in the gut lumen, greatly elevated enterocyte cell death and apoptosis, inter-enterocyte invasion of immune ..
  34. Attenuated malaria sporozoite vaccine using a P. falciparum blood-stage auxotroph
    STEPHEN LEV HOFFMAN; Fiscal Year: 2013
    ..These studies will establish a vaccine candidate with optimal immunogenicity and a critical safety feature of being unable to sustain replication in erythrocytes if any parasites break through from the liver.
  35. Fc receptor targeted therapy for immune hemolytic anemia
    Periasamy Selvaraj; Fiscal Year: 2009
    ..Further, our preliminary studies show that the CD16AIg dimer can block the phagocytosis of antibody-coated erythrocytes by mouse macrophages in vitro and block neutrophil extravasations and inflammation induced by ICs in vivo...
  36. Nitric oxide protects against microcirculatory complications of malaria
    LEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2010
    ..Adhesion of parasitized erythrocytes (pRBCs), platelets, and leukocytes occur during ECM and deficiency of selected cell adhesion molecules protects ..
  37. Cytoskeletal Regulation of Erythrocyte Glucose Transporter-1
    Athar H Chishti; Fiscal Year: 2012
    ..function by linking the spectrin-actin junctions to the membrane via glucose transporter-1 (GLUT1) in human erythrocytes. We will test this hypothesis under the following three aims: A1: GLUT1 interaction with the spectrin-actin ..
  38. Multi-ligand merozoite invasion blocking malaria vaccine
    B Kim Lee Sim; Fiscal Year: 2013
    ..stage of the parasite life cycle, and thus all sequelae of malaria disease begin when the parasite invades erythrocytes. Blocking parasite invasion of erythrocytes would prevent parasite replication and all clinical disease...
  39. Mass Spectrometry Strategies to Identify Lipid Biomarkers of Disease
    GAVIN EDMUND REID; Fiscal Year: 2012
    ..carcinoma (liver), and to correlate these changes with those occurring in the blood fractions (plasma, erythrocytes and leukocytes) of these subjects for use as potential clinically relevant biomarkers for early disease ..
  40. Mass Spectrometry Strategies to Identify Lipid Biomarkers of Disease
    GAVIN EDMUND REID; Fiscal Year: 2011
    ..carcinoma (liver), and to correlate these changes with those occurring in the blood fractions (plasma, erythrocytes and leukocytes) of these subjects for use as potential clinically relevant biomarkers for early disease ..
  41. Identification of vaccine candidates against severe malaria
    Andrew V Oleinikov; Fiscal Year: 2013
    ..Plasmodium falciparum parasite-infected erythrocytes (IE) adhere to the host endothelium and to red blood cells...
  42. The role of Fas-associated death domain in necroptosis in vivo
    Astar Winoto; Fiscal Year: 2013
    ..of dcFADD-/- mice showed that some of their phenotypes are surprisingly similar to DC-less mice with imbalance erythrocytes and myeloproliferative disease. At the same time, dcFADD-/- mice exhibit a modest increase of inflammation...
  43. BMP4 dependent stress erythropoiesis pathway in short-term radioprotection
    ROBERT FRANK PAULSON; Fiscal Year: 2013
    ..In healthy individuals, the bone marrow constantly generates new erythrocytes to replaced worn out cells. This process is referred to as steady state erythropoiesis...
  44. Identification of responding CD8+ T cells and novel protective epitopes following
    SEAN CHRISTOPHER MURPHY; Fiscal Year: 2013
    ..In Specific Aim 2, I will evaluate cross-priming of CTLs by malaria-infected erythrocytes and determine how such targets elicit cross-stage CTL immunity...
  45. A Controlled Clinical Trial of Regadenoson in Sickle Cell Anemia
    Donna S Neuberg; Fiscal Year: 2013
    ..The pathogenesis of vaso- occlusion is a multi-cellular process involving sickle and non-sickle erythrocytes, white blood cells, platelets, coagulation proteins and activated endothelium...
  46. Alternative Pathway Inhibitors for Orphan Indication
    REKHA BANSAL; Fiscal Year: 2013
    ..Recent studies have shown an increased level of C3b accumulation on erythrocytes in Eculizumab-treated patients, causing a prominent phenomenon - extravascular hemolysis (EVH)...
  47. FoxO6 in Glucose Metabolism
    Hengjiang Henry Dong; Fiscal Year: 2013
    ..Gluconeogenesis is a life-sustaining process for providing the sole fuel source for brain, testes and erythrocytes during starvation or prolonged fasting...
  48. VACCINE INDUCED IMMUNE RESPONSES TO PLASMODIAL ANTIGENS
    JAMES MATTHEW BURNS; Fiscal Year: 2012
    ..subunit vaccines to induce antibodies that neutralize extracellular merozoites and prevent the invasion of host erythrocytes. P...
  49. HCMV infection of human placental trophoblast and hematopoietic progenitors
    LENORE PALMA PEREIRA; Fiscal Year: 2012
    ..Cultured in defined medium, the CD34++CD45low HSCs contributed to erythrocytes and myeloid cells...
  50. Immunomodulatory functions of neuronal guidance cues
    Kathryn J Moore; Fiscal Year: 2010
    ..research, and specific Challenge Topic 04-HL-103 Assess the role of leukocyte interaction with platelets, erythrocytes, and endothelium in the pathogenesis of heart, lung, and blood diseases...
  51. Function and Inhibition of Plasmodium Lipid Decarboxylases
    Choukri Ben Mamoun; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): During its life cycle within human erythrocytes, Plasmodium falciparum undergoes major developmental and metabolic changes and multiplies to produce up to 36 new daughter parasites...
  52. Non-Invasive Localization of Vulnerable Plaques
    Cynthia McCollough; Fiscal Year: 2009
    ..Extravasation of erythrocytes and intra-plaque hemorrhage are considered critical factors in the transition of a plaque from the stable to ..
  53. Hemophagocytic Macrophages and Systemic Salmonella Infection
    CORRELLA DETWEILER; Fiscal Year: 2013
    ..and replicates within hemophagocytic macrophages (HM[unreadable]), which are macrophages that have engulfed erythrocytes, platelets, leukocytes and their precursor cells...
  54. Molecular Assembly on the Cell Surface of Actinomyces
    Hung Ton-That; Fiscal Year: 2013
    ..2 fimbriae mediates the receptor polysaccharide-dependent coaggregation with oral streptococci, adherence to erythrocytes and biofilm development...
  55. Mechanism and function of heme-iron utilization in staphylococcal pathogenesis
    Eric P Skaar; Fiscal Year: 2013
    ..aureus acquires heme from the most abundant heme source in the host, hemoglobin contained within circulating erythrocytes. The process of heme uptake and metabolism is performed by the iron regulated surface determinant system (Isd)...
  56. Microfluidic Processing of Leukocytes for Molecular Diagnostic Testing
    James C Sturm; Fiscal Year: 2012
    ..The key innovation of this STTR project is the use of DLD to remove leukocytes/leukemia cells from erythrocytes and also from labeling or other reagents in a continuous flow process, finally concentrating the target ..
  57. Fetal Immunity of Malaria
    Christopher L King; Fiscal Year: 2013
    ..In malaria in pregnancy, parasitized erythrocytes (irbc) sequester in the placenta and irbcs or their soluble products cross the placenta during gestation, ..
  58. Impact of Blood Storage Duration on Physiologic Measures: RECESS Ancillary Study
    CHRISTOPHER PUTNAM STOWELL; Fiscal Year: 2013
    ..optimal tissue viability, there must be adequate perfusion of the microcirculation and off-loading of oxygen by erythrocytes. We hypothesize that transfusion of RBCs stored for a longer time period decreases tissue oxygenation and ..
  59. Molecular analysis of a kinase essential for replication of Plasmodium falciparum
    Jeffrey D Dvorin; Fiscal Year: 2012
    ..P. falciparum requires efficient invasion into and egress out of human erythrocytes during the asexual replication stage of the parasite life cycle...
  60. Structural studies of a spectrin/ankyrin complex
    ALFONSO MONDRAGON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In erythrocytes, the reversible deformability needed to accomplish passage through capillaries is largely controlled by a vast network of proteins attached to the membrane...
  61. Development of Therapeutic CD59 inhibitor for treating B-cell malignancies
    Xuebin Qin; Fiscal Year: 2013
    ..CLL to RTX or OFA treatment;2) by itself ILYd4 does not adversely mediate in vivo hemolysis of hCD59-expressing erythrocytes;3) the sensitivity to CDC effects mediated by RTX or OFA on RTX-resistant NHL cell lines and CLL cells ..
  62. Molecular Regulation of Erythroid Differentiation
    Min Chen; Fiscal Year: 2013
    ..differentiate into erythroblasts, followed by the removal of the nucleus and organelles to develop into mature erythrocytes. Although the morphological changes associated with different stages of erythropoiesis have been well ..
  63. Identification of biomarkers of fatty acid intake
    Hannia Campos; Fiscal Year: 2002
    ..in all study participants to: 1) Compare the ability of non-endogenously synthesized fatty acids in plasma, erythrocytes, whole blood and adipose tissue to reflect fatty acid intake, 2) Determine the distribution of individual fatty ..
  64. CYTOCHROME B5--A CASE STUDY IN MOLECULAR RECOGNITION
    Mario Rivera; Fiscal Year: 1999
    ..The form found in erythrocytes is involved in the pathway for methemoglobin reduction...
  65. Falciparum malaria invasion ligand DNA/protein vaccine
    David Narum; Fiscal Year: 2002
    ..Pf invades erythrocytes (RBCs) by attaching to surface receptors, one of which includes sialic acids...
  66. Role of Red Cell Membrane in Malaria Parasite Release
    Manjit Hanspal; Fiscal Year: 2006
    ..RBCs) the parasite replicates into infective merozoites, which must then exit the host cell to invade new erythrocytes. Mounting evidence suggests that proteases are involved in host cell rupture and parasite release, although the ..
  67. ENZYMATIC PRODUCTION OF UNIVERSAL DONOR ERYTHROCYTES
    LANSING HOSKINS; Fiscal Year: 1993
    ..abstract) This project is intended to determine the feasibility of converting human blood type A and type B erythrocytes to universal donor blood type O erythrocytes by treatment with blood group-specific glycosidases purified from ..
  68. REGULATION OF PHOSPHOLIPASE C
    T Harden; Fiscal Year: 1992
    ..C by reconstitution of GTP gamma S-pre-activated proteins will be used to identify the protein in turkey erythrocytes that activates phospholipase C and to compare the relative activities of G-proteins purified from turkey ..
  69. CHANNEL-MEDIATED RBC DEHYDRATION IN SICKLE CELL DISEASE
    Alicia Rivera; Fiscal Year: 2003
    ..Dehydration of hemoglobin S-containing erythrocytes favors the formation of dense cells due to increased hemoglobin S polymerization in sickle cell disease...
  70. ERYTHROCYTE ADHESION IN FALCIPARUM MALARIA
    IRWIN SHERMAN; Fiscal Year: 2004
    ..Cerebral malaria, a complication of P. falciparum infections, is associated with sequestration of erythrocytes in the blood vessels of the brain and is due to the adhesion of malaria-infected erythrocytes (PE) to the ..
  71. IRON AND OXYGEN CHEMISTRIES IN SIPUNCULAN BLOOD
    DONALD KURTZ; Fiscal Year: 1992
    ..various constituents on the chemistry of hemerythrin, the non-heme iron oxygen-carrying protein in sipunculan erythrocytes. It is hoped that these factors will be easier to unravel in the more primitive sipunculans, and that their ..
  72. PHOSPHOINOSITIDES IN NORMAL AND ABNORMAL HUMAN RED CELLS
    George Dale; Fiscal Year: 1992
    ..of the present proposal is to understand the physiological function and enzymology of the phosphoinositides in erythrocytes. The first goal is to purify and characterize phosphatidylinositol 4-phosphate kinase...