blood platelets

Summary

Summary: Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.

Top Publications

  1. pmc Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes
    Jesse W Rowley
    Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA
    Blood 118:e101-11. 2011
  2. ncbi Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
    T K Vu
    Department of Medicine, University of California, San Francisco 94143 0524
    Cell 64:1057-68. 1991
  3. pmc Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis
    Myriam Labelle
    Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cancer Cell 20:576-90. 2011
  4. pmc Platelets amplify inflammation in arthritis via collagen-dependent microparticle production
    Eric Boilard
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 327:580-3. 2010
  5. ncbi Platelets and the immune continuum
    John W Semple
    Toronto Platelet Immunobiology Group, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada, M5B 1W8
    Nat Rev Immunol 11:264-74. 2011
  6. ncbi Contribution of platelets to tumour metastasis
    Laurie J Gay
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Rev Cancer 11:123-34. 2011
  7. ncbi Programmed anuclear cell death delimits platelet life span
    Kylie D Mason
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Cell 128:1173-86. 2007
  8. ncbi Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)
    David M Dohan Ehrenfest
    Department of Biomaterials, Institute of Clinical Sciences, the Sahlgrenska Academy at University of Gothenburg, Sweden
    Trends Biotechnol 27:158-67. 2009
  9. pmc Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released
    Joseph E Italiano
    Translational Medicine Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 111:1227-33. 2008
  10. ncbi Protease-activated receptors in hemostasis, thrombosis and vascular biology
    S R Coughlin
    Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, CA 94143 0130, USA
    J Thromb Haemost 3:1800-14. 2005

Research Grants

Detail Information

Publications379 found, 100 shown here

  1. pmc Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes
    Jesse W Rowley
    Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA
    Blood 118:e101-11. 2011
    ..The sequencing dataset will be useful in the design of mouse models of hemostasis and a catalyst for discovery of new functions of platelets. Access to the dataset is found in the "Introduction."..
  2. ncbi Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
    T K Vu
    Department of Medicine, University of California, San Francisco 94143 0524
    Cell 64:1057-68. 1991
    ..These data reveal a novel signaling mechanism in which thrombin cleaves its receptor's amino-terminal extension to create a new receptor amino terminus that functions as a tethered ligand and activates the receptor...
  3. pmc Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis
    Myriam Labelle
    Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cancer Cell 20:576-90. 2011
    ..Thus, cancer cells rely on platelet-derived signals outside of the primary tumor for efficient metastasis...
  4. pmc Platelets amplify inflammation in arthritis via collagen-dependent microparticle production
    Eric Boilard
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 327:580-3. 2010
    ..Thus, these findings demonstrate a previously unappreciated role for platelets and their activation-induced microparticles in inflammatory joint diseases...
  5. ncbi Platelets and the immune continuum
    John W Semple
    Toronto Platelet Immunobiology Group, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada, M5B 1W8
    Nat Rev Immunol 11:264-74. 2011
    ..Here, we discuss the mechanisms by which platelets contribute to immunity: these small cells are more immunologically savvy than we once thought...
  6. ncbi Contribution of platelets to tumour metastasis
    Laurie J Gay
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Rev Cancer 11:123-34. 2011
    ..These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy...
  7. ncbi Programmed anuclear cell death delimits platelet life span
    Kylie D Mason
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Cell 128:1173-86. 2007
    ....
  8. ncbi Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)
    David M Dohan Ehrenfest
    Department of Biomaterials, Institute of Clinical Sciences, the Sahlgrenska Academy at University of Gothenburg, Sweden
    Trends Biotechnol 27:158-67. 2009
    ..This classification should help to elucidate successes and failures that have occurred so far, as well as providing an objective approach for the further development of these techniques...
  9. pmc Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released
    Joseph E Italiano
    Translational Medicine Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 111:1227-33. 2008
    ....
  10. ncbi Protease-activated receptors in hemostasis, thrombosis and vascular biology
    S R Coughlin
    Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, CA 94143 0130, USA
    J Thromb Haemost 3:1800-14. 2005
    ....
  11. pmc Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells
    Naoya Takayama
    Stem Cell Bank, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, Tokyo, Japan
    J Exp Med 207:2817-30. 2010
    ..These findings suggest that the pattern of c-MYC expression, particularly its later decline, is key to producing functional platelets from selected iPSC clones...
  12. pmc Platelet alpha-granules: basic biology and clinical correlates
    Price Blair
    Department of Medicine, Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Blood Rev 23:177-89. 2009
    ..This review will consider the formation, release, and physiologic roles of alpha-granules with special emphasis on work performed over the last decade...
  13. pmc Platelets in inflammation and atherogenesis
    Meinrad Gawaz
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    J Clin Invest 115:3378-84. 2005
    ..This Review highlights the molecular machinery and inflammatory pathways used by platelets to initiate and accelerate atherothrombosis...
  14. ncbi Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions
    Judith A Coppinger
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    Blood 103:2096-104. 2004
    ..Moreover, as soluble extracellular proteins, they may prove suitable as novel therapeutic targets...
  15. ncbi Platelet-rich plasma: evidence to support its use
    Robert E Marx
    Department of Oral and Maxillofacial Surgery, University of Miami School of Medicine and Jackson Memorial Hospital, Miami, FL, USA
    J Oral Maxillofac Surg 62:489-96. 2004
  16. ncbi Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: studies in baboons, human coronary intervention, and human acute myocardial infarction
    A D Michelson
    Center for Platelet Function Studies, Departments of Pediatrics and Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Circulation 104:1533-7. 2001
    ..Platelet surface P-selectin is considered the "gold standard" marker of platelet activation. Degranulated, P-selectin-positive platelets, however, aggregate with leukocytes in vitro and rapidly lose surface P-selectin in vivo...
  17. ncbi Human platelet lysate can replace fetal bovine serum for clinical-scale expansion of functional mesenchymal stromal cells
    Katharina Schallmoser
    Department of Blood Group Serology and Transfusion Medicine, Division of Hematology and Stem Cell Transplantation, Medical University, Auenbrugger Platz 38, A 8036 Graz, Austria
    Transfusion 47:1436-46. 2007
    ..Translation of auspicious experimental results into clinical applications has been limited by the dependence of MSC propagation from fetal bovine serum (FBS)...
  18. ncbi Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3
    Jaewon Han
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Curr Biol 16:1796-806. 2006
    ..Many different signaling molecules that regulate integrin affinity have been described, but a pathway that connects agonist stimulation to talin binding and activation has not been mapped...
  19. pmc A mechanically stabilized receptor-ligand flex-bond important in the vasculature
    Jongseong Kim
    Immune Disease Institute, Children s Hospital Boston and Department of Pathology, Harvard Medical School, 3 Blackfan Circle, Boston, Massachusetts 02115, USA
    Nature 466:992-5. 2010
    ..The results have important implications not only for how platelets bound to VWF are able to resist force to plug arterioles, but also how increased flow activates platelet plug formation...
  20. ncbi The role of platelets in atherothrombosis
    Zane S Kaplan
    Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct, Monash University, Melbourne, Australia
    Hematology Am Soc Hematol Educ Program 2011:51-61. 2011
    ....
  21. ncbi Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate
    Laurent Bonello
    Department of Cardiology, Institut National de la Santè et de la Recherche Médicale Unité Mixte de Recherche 608, Hopital Universitaire Nord, Faculte de Medecine, Marseille, France
    J Am Coll Cardiol 56:919-33. 2010
    ..This review provides a consensus opinion on the definition of high on-treatment platelet reactivity to ADP based on various methods reported in the literature and proposes how this measurement may be used in the future care of patients...
  22. ncbi Treatment of recalcitrant ulcers with allogeneic platelet gel from pooled platelets in aged hypomobile patients
    N Greppi
    Center of Transfusion Medicine and Immunohematology, Department of Regenerative Medicine, Foundation IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    Biologicals 39:73-80. 2011
    ..This study supports efficacy and feasibility of allogeneic PG to treat recalcitrant ulcers in very elderly hypomobile patients for whom autologous blood processing may be difficult...
  23. ncbi Platelets and innate immunity
    John W Semple
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada
    Cell Mol Life Sci 67:499-511. 2010
    ....
  24. ncbi Proplatelet formation is regulated by the Rho/ROCK pathway
    Yunhua Chang
    Institut National de la Sante et de la Recherche Medicale, Unité U 790, Pavillon de Recherche 1, Institut Gustave Roussy, Villejuif, France
    Blood 109:4229-36. 2007
    ..Taken together, our results suggest that MLC2 phosphorylation is regulated by both ROCK and MLC kinase and plays an important role in platelet biogenesis by controlling PPF and fragmentation...
  25. pmc Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity
    Srikanth Nagalla
    Thomas Jefferson University, Cardeza Foundation for Hematologic Research, and the Department of Medicine, Jefferson Medical College, Philadelphia, PA, USA
    Blood 117:5189-97. 2011
    ....
  26. ncbi Platelet activation and atherothrombosis
    Giovanni Davi
    Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    N Engl J Med 357:2482-94. 2007
  27. ncbi A shear gradient-dependent platelet aggregation mechanism drives thrombus formation
    Warwick S Nesbitt
    The Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Educational Precinct, Melbourne, Victoria, Australia
    Nat Med 15:665-73. 2009
    ..These findings provide insight into the prothrombotic effects of disturbed blood flow parameters and suggest a fundamental reinterpretation of the mechanisms driving platelet aggregation and thrombus growth...
  28. ncbi Dynamic visualization of thrombopoiesis within bone marrow
    Tobias Junt
    Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Science 317:1767-70. 2007
    ..These results confirm the concept of proplatelet formation in vivo and are consistent with the possibility that blood flow-induced hydrodynamic shear stress is a biophysical determinant of thrombopoiesis...
  29. pmc Existence of a microRNA pathway in anucleate platelets
    Patricia Landry
    Centre de Recherche en Rhumatologie et Immunologie, CHUL Research Center CHUQ, and Faculty of Medicine, Universite Laval, Quebec, Quebec, Canada
    Nat Struct Mol Biol 16:961-6. 2009
    ..Our study lends an additional level of complexity to the control of gene expression in these anucleate elements of the cardiovascular system...
  30. ncbi CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
    V Henn
    Molecular Immunology, Robert Koch Institute, Berlin, Germany
    Nature 391:591-4. 1998
    ..Our results indicate that platelets are not only involved in haemostasis but that they also directly initiate an inflammatory response of the vessel wall...
  31. ncbi Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow
    Karen Bieback
    Institute of Transfusion Medicine and Immunology, German Red Cross Blood Service of Baden Württemberg Hessen, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Stem Cells 27:2331-41. 2009
    ..Telomerase activity was not detected in any of the cultures at any passage. In contrast to previous data from adipose tissue-derived MSCs, pHPL was found to be the most suitable FBS substitute in clinical scale BM-MSC expansion...
  32. ncbi Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors
    Naoya Takayama
    Laboratory of Stem Cell Therapy, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Blood 111:5298-306. 2008
    ..This novel protocol thus provides a means of generating platelets from hESCs, which could serve as the basis for efficient production of platelets for clinical transfusion and studies of thrombopoiesis...
  33. ncbi Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor
    Yoka H Kusumanto
    Department of Medical Oncology, University Hospital Groningen, Groningen, The Netherlands
    Angiogenesis 6:283-7. 2003
    ..Therefore, future studies on the clinical value of circulating VEGF as a prognostic factor in cancer patients should include measurements of VEGF in peripheral blood cells...
  34. ncbi Platelet reactivity and cardiovascular outcomes after percutaneous coronary intervention: a time-dependent analysis of the Gauging Responsiveness with a VerifyNow P2Y12 assay: Impact on Thrombosis and Safety (GRAVITAS) trial
    Matthew J Price
    Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA, USA
    Circulation 124:1132-7. 2011
    ..The aim of this analysis was to examine the relationship between outcomes and OTR over the course of the trial...
  35. ncbi Microparticles from patients with multiple organ dysfunction syndrome and sepsis support coagulation through multiple mechanisms
    K Joop
    Department of Clinical Chemistry, Leiden University Medical Center, The Netherlands
    Thromb Haemost 85:810-20. 2001
    ..62, p = 0.013). CONCLUSIONS: In patients with MODS and sepsis relatively low numbers of MP are present that differ from controls in their cellular origin, numbers and coagulation activation mechanisms...
  36. pmc An important role for Akt3 in platelet activation and thrombosis
    Kelly A O'Brien
    Department of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA
    Blood 118:4215-23. 2011
    ..Importantly, Akt3(-/-) mice showed retardation in FeCl₃-induced carotid artery thrombosis in vivo. Thus, Akt3 plays an important and distinct role in platelet activation and in thrombosis...
  37. ncbi Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
    Stephen R Clark
    Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Nat Med 13:463-9. 2007
    ..We propose that platelet TLR4 is a threshold switch for this new bacterial trapping mechanism in severe sepsis...
  38. ncbi Platelet-derived CD40L: the switch-hitting player of cardiovascular disease
    Patrick Andre
    Circulation 106:896-9. 2002
  39. ncbi Novel roles of cAMP/cGMP-dependent signaling in platelets
    A Smolenski
    UCD Conway Institute, UCD School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
    J Thromb Haemost 10:167-76. 2012
    ..This article focuses on recent insights into the regulation of the cAMP/cGMP signaling network and on new targets of PKA and PKG in platelets...
  40. pmc Lipopolysaccharide signaling without a nucleus: kinase cascades stimulate platelet shedding of proinflammatory IL-1β-rich microparticles
    G Thomas Brown
    Medical Scientist Training Program, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Immunol 186:5489-96. 2011
    ..Platelets contribute to the inflammatory response to LPS through production of microparticles that promote endothelial cell activation...
  41. ncbi cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets
    E Butt
    Medizinische Universitatsklinik, Klinische Biochemie und Pathobiochemie, Federal Republic of Germany
    J Biol Chem 269:14509-17. 1994
    ....
  42. ncbi Platelet functions beyond hemostasis
    S S Smyth
    Lexington VA Medical Center and Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY 40536, USA
    J Thromb Haemost 7:1759-66. 2009
    ....
  43. ncbi Characterization of human platelet microRNA by quantitative PCR coupled with an annotation network for predicted target genes
    Abdimajid Osman
    Linkoping University, Clinical and Experimental Medicine, Department of Clinical Chemistry, SE 581 85 Linkoping, Sweden
    Platelets 22:433-41. 2011
    ..The proposed functional network, combining computational prediction analysis with annotations from experimental observations, may in addition provide some information about probable miRNA target pathways in human platelets...
  44. ncbi Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation
    Ian Del Conde
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, N 1317, Houston, TX 77030, USA
    Blood 106:1604-11. 2005
    ..These findings suggest a mechanism by which all of the membrane-bound reactions of the coagulation system can be localized to the surface of activated platelets...
  45. ncbi Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation
    Pavel Uhrin
    Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
    Blood 115:3997-4005. 2010
    ..Therefore, interaction of endothelial podoplanin of the developing lymph sac with circulating platelets from the cardinal vein is critical for separating the lymphatic from the blood vascular system...
  46. pmc Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo
    Steffen Massberg
    Deutsches Herzzentrum and Medizinische Klinik, Technical University of Munich, D 80636 Munich, Germany
    J Exp Med 203:1221-33. 2006
    ..These findings establish the platelet as a major player in the initiation of vascular remodeling, a process of fundamental importance for vascular repair and pathological remodeling after vascular injury...
  47. ncbi NAD(P)H oxidase-dependent platelet superoxide anion release increases platelet recruitment
    Florian Krotz
    Institute of Physiology and the Department of Internal Medicine, Ludwig Maximilians University Munich, Schillerstr 44, 80336 Munich, Germany
    Blood 100:917-24. 2002
    ..These results strongly suggest that collagen activation induces NAD(P)H oxidase-dependent O release in platelets, which in turn enhances availability of released ADP, resulting in increased platelet recruitment...
  48. pmc Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis
    K Przyklenk
    Center for Platelet Function Studies, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    J Thromb Haemost 8:331-40. 2010
    ..However, earlier-generation serotonin receptor antagonists were not successfully exploited as antiplatelet agents, possibly owing to their lack of specificity for the 5HT2A receptor subtype...
  49. pmc mTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected]
    Samantha F Moore
    School of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 286:24553-60. 2011
    ..Together, these results demonstrate that mTORC2 is the kinase that phosphorylates Akt Ser(473) in human platelets but that this phosphorylation is dispensable for Thr(308) phosphorylation and Akt1 activity...
  50. ncbi Platelets at work in primary hemostasis
    Katleen Broos
    Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Campus Kortrijk, Belgium
    Blood Rev 25:155-67. 2011
    ..With this review, we intend to give an integrated survey of the platelet response to vascular injury in normal hemostasis...
  51. pmc Platelet lysate from whole blood-derived pooled platelet concentrates and apheresis-derived platelet concentrates for the isolation and expansion of human bone marrow mesenchymal stromal cells: production process, content and identification of active comp
    Natalie Fekete
    Institut fur Transfusionsmedizin, Universität Ulm und Institut für Klinische Transfusionsmedizin und Immungenetik Ulm, DRK Blutspendedienst Baden Württemberg Hessen, Germany
    Cytotherapy 14:540-54. 2012
    ..The clinical use of human mesenchymal stromal cells (MSC) requires ex vivo expansion in media containing supplements such as fetal bovine serum or, alternatively, human platelet lysate (PL)...
  52. ncbi Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features
    David M Dohan
    Biophysics Laboratory, Faculty of Dental Surgery, University of Paris V, Paris, France
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:e45-50. 2006
    ..This result would imply that PRF, unlike the other platelet concentrates, would be able to progressively release cytokines during fibrin matrix remodeling; such a mechanism might explain the clinically observed healing properties of PRF...
  53. pmc Platelets, petechiae, and preservation of the vascular wall
    Ralph L Nachman
    Weill Cornell Medical College, New York, NY 10065, USA
    N Engl J Med 359:1261-70. 2008
  54. ncbi Mean platelet volume in patients with metabolic syndrome and its relationship with coronary artery disease
    Yusuf Tavil
    Gazi University Medical School, Department of Cardiology, Ankara, Turkey
    Thromb Res 120:245-50. 2007
    ..MS has also been shown to be strongly associated with poor outcome in patients with coronary artery disease (CAD). The present study was designed to investigate MPV values in patients MS and to interrogate the association with CAD...
  55. ncbi Platelet lysates promote mesenchymal stem cell expansion: a safety substitute for animal serum in cell-based therapy applications
    Christelle Doucet
    Département Recherches, centre de transfusion sanguine des armées Jean Julliard, Clamart Cedex, France
    J Cell Physiol 205:228-36. 2005
    ..Therefore, we propose that PL may be a powerful and safe substitute for FCS in development of tissue- and cellular-engineered products in clinical settings using MSCs...
  56. pmc Platelets influence vascularized organ transplants from start to finish
    A D Kirk
    Emory Transplant Center, Department of Surgery, Emory University, Atlanta, GA, USA
    Am J Transplant 9:14-22. 2009
    ..There is a potential for therapy to inhibit platelet mediated immune stimulation, but it is counterbalanced by the need to maintain coagulation in the perioperative period...
  57. ncbi Circulating microparticles: a potential prognostic marker for atherosclerotic vascular disease
    Chantal M Boulanger
    Institut National de la Sante et de la Recherche Medicale, Cardiovascular Research Center INSERM Lariboisière, Paris, France
    Hypertension 48:180-6. 2006
  58. pmc Central role of the P2Y12 receptor in platelet activation
    Robert T Dorsam
    Department of Pharmacology, Temple University Medical School, Philadelphia, Pennsylvania 19140, USA
    J Clin Invest 113:340-5. 2004
    ..The P2Y(12) receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y(12) receptor antagonists that have proven therapeutic value...
  59. ncbi Circulating microparticles: pathophysiology and clinical implications
    Andrea Piccin
    Irish Blood Transfusion Service, James s Street, Dublin 8, Ireland
    Blood Rev 21:157-71. 2007
    ..In addition the complex role of microparticles in vascular and cardiovascular diseases is an area of immense interest, that promises to yield important advances into diagnosis and therapy...
  60. ncbi Mean platelet volume as an indicator of platelet activation: methodological issues
    Yongsoon Park
    Department of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Platelets 13:301-6. 2002
    ..Mean platelet volume (MPV) is increased in patients at high risk for athero-thrombotic diseases. Thus, an elevated MPV may be a risk marker for platelet activation...
  61. ncbi Identification of the platelet ADP receptor targeted by antithrombotic drugs
    G Hollopeter
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143, USA
    Nature 409:202-7. 2001
    ..Cloning of the P2Y12 receptor should facilitate the development of better antiplatelet agents to treat cardiovascular diseases...
  62. ncbi Autologous platelets as a source of proteins for healing and tissue regeneration
    Eduardo Anitua
    Biotechnology Unit, IFR No 4, Hopital Cardiologique, Avenue Magellan, 33604 Pessac, France
    Thromb Haemost 91:4-15. 2004
    ..Our aim is to review these advances and discuss the ways in which platelets may provide such unexpected beneficial therapeutic effects...
  63. pmc Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets
    R Mohle
    Developmental Hematopoiesis Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:663-8. 1997
    ..Within the bone marrow microenvironment, VEGF secreted by megakaryocytes may contribute to the proliferation of endothelial cells. VEGF delivered to sites of vascular injury by activated platelets may initiate angiogenesis...
  64. pmc Increased platelet and microparticle activation in HIV infection: upregulation of P-selectin and tissue factor expression
    Elizabeth Mayne
    National Health Laboratory Services and University of Witwatersrand, Johannesburg, South Africa
    J Acquir Immune Defic Syndr 59:340-6. 2012
    ..In this study, we explore the activation state of platelets in HIV disease...
  65. ncbi Role of blood platelets in infection and inflammation
    Matthias H F Klinger
    Department of Anatomy, University of Lubeck, D 23538 Lubeck, Germany
    J Interferon Cytokine Res 22:913-22. 2002
    b>Blood platelets are here presented as active players in antimicrobial host defense and the induction of inflammation and tissue repair in addition to their participation in hemostasis...
  66. pmc Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis
    S G Chu
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Thromb Haemost 8:148-56. 2010
    ..Platelet activity is a major culprit in atherothrombotic events. MPV, which is widely available in clinical practice, is a potentially useful biomarker of platelet activity in the setting of cardiovascular disease...
  67. pmc Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets
    Katsue Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    J Biol Chem 285:24494-507. 2010
    ..We propose that CLEC-2 could be an ideal novel target protein for an anti-platelet drug, which inhibits pathological thrombus formation but not physiological hemostasis...
  68. pmc Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function
    Alison H Goodall
    Department of Cardiovascular Science, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester, UK
    Blood 116:4646-56. 2010
    ..Taken together, these data reveal novel proteins regulating the platelet response...
  69. pmc Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf
    Yukako Ono
    Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Blood 120:3812-21. 2012
    ..These findings demonstrate that a combination of p45NF-E2, Maf G, and Maf K is a key determinant of both megakaryopoiesis and thrombopoiesis...
  70. pmc Human platelet-rich plasma- and extracellular matrix-derived peptides promote impaired cutaneous wound healing in vivo
    Tatiana N Demidova-Rice
    Graduate Program in Cellular and Molecular Physiology, Sackler School of Graduate Biomedical Sciences, The Center for Innovations in Wound Healing Research, Tufts University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 7:e32146. 2012
    ..Our current work is aimed at understanding the mechanisms underlying the stimulatory effects of these peptides as well as identification of the cellular receptors mediating these effects...
  71. pmc A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing
    Weiyi Feng
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH
    Blood 117:3893-902. 2011
    ..Our data demonstrate that platelets stimulate BMDC homing in a VAMP-8-dependent manner, revealing a previously unknown role for platelets as key mediators between hypoxic tissues and the bone marrow during angiogenesis...
  72. ncbi Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis
    Irina Pleines
    Chair of Vascular Medicine, University Hospital Würzburg and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, Josef Schneider Strasse 2, Wurzburg, Germany
    Blood 119:1054-63. 2012
    ..Together, these results establish RhoA as an important regulator of platelet function in thrombosis and hemostasis...
  73. ncbi Platelet size: measurement, physiology and vascular disease
    P M Bath
    Department of Medicine, King s College School of Medicine and Dentistry, London, UK
    Blood Coagul Fibrinolysis 7:157-61. 1996
    ..Similarly, the physiological mechanisms which regulate MPV within the megakaryocyte need to be elucidated. Whether MPV ever becomes a routinely requested test remains to be seen but changes in methodology will be required first...
  74. ncbi Expansion of adipose mesenchymal stromal cells is affected by human platelet lysate and plating density
    Dominik Cholewa
    Stem Cell Biology and Cellular Engineering, Medical Faculty, RWTH Aachen University, Aachen, Germany
    Cell Transplant 20:1409-22. 2011
    ..Cellular automaton computer simulations provided additional insights into how complex population dynamics during long-term expansion are affected by plating density and migration...
  75. pmc Nanomedicine for the reduction of the thrombogenicity of stent coatings
    Varvara C Karagkiozaki
    Aristotle University of Thessaloniki, Medical School, AHEPA University General Hospital, 1st Cardiology Department, Cardiovascular Engineering and Atherosclerosis Laboratory, Greece
    Int J Nanomedicine 5:239-48. 2010
    ..This is an actual solution for improving the stent coating fabrication...
  76. pmc Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood
    Nicholas Pugh
    Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
    Blood 115:5069-79. 2010
    ....
  77. pmc Rap1b is required for normal platelet function and hemostasis in mice
    Magdalena Chrzanowska-Wodnicka
    Department of Medicine and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 115:680-7. 2005
    ..These data provide genetic evidence that Rap1b is involved in a common pathway of integrin activation, is required for normal hemostasis in vivo, and may be a clinically relevant antithrombotic therapy target...
  78. ncbi Blood platelets and inflammation: their relationship with liver and digestive diseases
    J Ripoche
    INSERM U889, Universite Victor Segalen Bordeaux, 146, rue Leo Saignat, 33076 Bordeaux, France
    Clin Res Hepatol Gastroenterol 35:353-7. 2011
    ..Here, we summarize some of the mechanisms linking platelets with inflammation and comment few recent articles indicating why platelets may prove to be important pathogenic mediators in liver and gastrointestinal diseases...
  79. pmc Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice
    Shi Jiang Lu
    Stem Cell and Regenerative Medicine International, 33 Locke Drive, Marlborough, MA 01752, USA
    Cell Res 21:530-45. 2011
    ..and morphological features of hESC-derived platelets were indistinguishable from those of normal blood platelets. In functional assays, hESC-derived platelets responded to thrombin stimulation, formed microaggregates, and ..
  80. ncbi The interaction of bacterial pathogens with platelets
    J Ross Fitzgerald
    Centre for Infectious Diseases, The Chancellor s Building, New Royal Infirmary, University of Edinburgh, Edinburgh EH16 4SB, Scotland, UK
    Nat Rev Microbiol 4:445-57. 2006
    ..Here, we review the nature of the interactions between platelets and bacteria, and the role of these interactions in the pathogenesis of endocarditis and other cardiovascular diseases...
  81. ncbi Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice
    B Nieswandt
    Department of Molecular Oncology, General Surgery, University of Witten Herdecke, Wuppertal, Germany
    Blood 96:2520-7. 2000
    ....
  82. ncbi Signaling events underlying thrombus formation
    S P Jackson
    Australian Center for Blood Diseases, Department of Medicine, Monash Medical School, Box Hill Hospital, Box Hill, Victoria, Australia
    J Thromb Haemost 1:1602-12. 2003
    ..The role of soluble agonists in promoting thrombus growth will be highlighted and a model to explain the synergistic requirement for adhesive and soluble stimuli for efficient platelet aggregation will be discussed...
  83. ncbi Impact of individual platelet lysates on isolation and growth of human mesenchymal stromal cells
    Patrick Horn
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Cytotherapy 12:888-98. 2010
    ..Several studies have demonstrated that pooled human platelet lysate (HPL) provides an attractive alternative for FCS. However, little is known about the variation between different platelet lysates...
  84. pmc PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation
    Michael Holinstat
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    J Biol Chem 281:26665-74. 2006
    ..Thus, our data identify an intra-platelet mechanism that may function as a future site for therapeutic intervention...
  85. ncbi Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development
    R A Shivdasani
    Division of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Cell 81:695-704. 1995
    Despite the importance of blood platelets in health and disease, the mechanisms regulating their formation within megakaryocytes are unknown...
  86. ncbi Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events
    Aileen M Healy
    Millennium Pharmaceuticals, Inc, Cambridge, MA, USA
    Circulation 113:2278-84. 2006
    ..Because platelets lack nuclear DNA but retain megakaryocyte-derived mRNAs, the platelet transcriptome provides a novel window on gene expression preceding acute coronary events...
  87. ncbi Microparticles in cardiovascular diseases
    Marja J VanWijk
    Department of Obstetrics and Gynaecology, Academic Medical Center, Amsterdam, The Netherlands
    Cardiovasc Res 59:277-87. 2003
    ....
  88. pmc Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease
    Nalini Raghavachari
    Vascular Medicine Branch, National Heart, Lung, and Blood Institute National Institutes of Health, Bethesda, MD 20892 1454, USA
    Circulation 115:1551-62. 2007
    ..Recent functional studies of platelets in patients with sickle cell disease reveal a basally activated state, which suggests that pathological platelet activation may contribute to sickle cell disease vasculopathy...
  89. ncbi Evaluation of single and double centrifugation tube methods for concentrating equine platelets
    D Arguelles
    Department of Animal Medicine and Surgery, Universitat Autonoma de Barcelona, 08193, Cerdanyola del Valles, Spain
    Res Vet Sci 81:237-45. 2006
    ..In conclusion, the single and double centrifugation tube methods are reliable methods for concentrating equine platelets and for obtaining potentially therapeutic TGF-beta(1) levels...
  90. ncbi Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum
    Y Yatomi
    Department of Laboratory Medicine, Yamanashi Medical University, Nakakoma gun
    J Biochem 121:969-73. 1997
    ....
  91. pmc Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling
    Cara C Bertozzi
    Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Blood 116:661-70. 2010
    ..These studies identify a nonhemostatic pathway in which platelet CLEC-2 receptors bind lymphatic endothelial PDPN and activate SLP-76 signaling to regulate embryonic vascular development...
  92. ncbi Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis
    M Majka
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Blood 96:4142-51. 2000
    ..This study expands the understanding of the role of SDF-1 and TPO in normal human megakaryopoiesis and indicates the molecular basis of the observed differences in cellular responses. (Blood. 2000;96:4142-4151)..
  93. ncbi Platelets kill intraerythrocytic malarial parasites and mediate survival to infection
    Brendan J McMorran
    Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
    Science 323:797-800. 2009
    ..These results indicate a protective function for platelets in the early stages of erythrocytic infection distinct from their role in cerebral malaria...
  94. ncbi The platelet release reaction: granules' constituents, secretion and functions
    F Rendu
    U428 INSERM, Faculte de Pharmacie, 4 avenue de l Observatoire, 75006 Paris, France
    Platelets 12:261-73. 2001
    Although anucleated, blood platelets are highly organized cells rich in different types of organelles. Three specific granule populations store different types of constituents, some of which are at high concentrations...
  95. ncbi Dual regulation of platelet protein kinase B
    C Kroner
    Department of Haematology, Laboratory for Thrombosis and Haemostasis, University Medical Center Utrecht and Institute for Biomembranes, Utrecht University, 3584 CX Utrecht, The Netherlands
    J Biol Chem 275:27790-8. 2000
    ..The independent control of the two phosphorylation sites may contribute to fine regulation of PKBalpha activity...
  96. pmc Signaling during platelet adhesion and activation
    Zhenyu Li
    Department of Medicine, University of Kentucky, Lexington, USA
    Arterioscler Thromb Vasc Biol 30:2341-9. 2010
    ..Recent studies have provided novel insight into the molecular mechanisms of these processes...
  97. ncbi An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume
    Osman Yuksel
    Department of Gastroenterology, Dişkapi Yildirim Beyazit Hospital, Ankara, Turkey
    Platelets 20:277-81. 2009
    ..005). In UC, MPV did not correlate with ESR, CRP and white blood cell. Our study showed that MPV reduced in UC, particularly in patients with active UC. Decreased MPV may be an indicator for increased disease activity in patients with UC...
  98. pmc A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo
    Steffen Massberg
    Deutsches Herzzentrum und 1 Medizinische Klinik, Technische Universitat Munchen, D 80636 München, Germany
    J Exp Med 197:41-9. 2003
    ....
  99. pmc Nanoparticle-induced platelet aggregation and vascular thrombosis
    Anna Radomski
    Centre for Vascular Biology, Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Centre at Houston, 6770 Bertner Ave, Houston, TX 77025, USA
    Br J Pharmacol 146:882-93. 2005
    ..These observations are of importance for the pharmacological use of carbon nanoparticles and pathology of urban particulate matter...
  100. ncbi P2 receptors, platelet function and pharmacological implications
    Christian Gachet
    Institut National de la Sante et de la Recherche Medicale, U311, Strasbourg, France
    Thromb Haemost 99:466-72. 2008
    ..Finally, the regulation by the P2 receptors of the platelet involvement in inflammatory processes is also briefly discussed...
  101. ncbi Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures
    Marianna Prokopi
    King s British Heart Foundation Centre, King s College London, 125 Coldharbour Lane, London, United Kingdom
    Blood 114:723-32. 2009
    ....

Research Grants64

  1. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh A Shivdasani; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Blood platelets are required for hemostasis and abnormal platelet activation leads to thrombosis...
  2. Molecular Mechanisms of Ion Channels in T Lymphocytes
    Michael D Cahalan; Fiscal Year: 2013
    ..Important cellular functions of Orai1 have been identified in lymphocytes, mast cells, blood platelets, sweat and salivary glands, dentition, vascular smooth muscle, endothelial cells, and skeletal muscle...
  3. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2012
    ..PROJECT NARRATIVE The role of circulating blood platelets is to prevent blood loss...
  4. Platelet-Derived FVIII Gene Therapy of Hemophilia A
    Qizhen Shi; Fiscal Year: 2013
    ..In this project, we will develop a gene therapy approach by targeting the synthesis of FVIII to blood platelets, that might cure hemophilia A patients as well as patients with inhibitors.
  5. Pro-inflammatory role of megakaryocytes in arthritis
    Peter A Nigrovic; Fiscal Year: 2013
    ..that the megakaryocyte, a bone marrow cell recognized principally for its role in the generation of blood platelets, has an unrecognized activity in the promotion of joit inflammation...
  6. A Novel Electrospun Vascular Graft
    David J Vachon; Fiscal Year: 2010
    ..g. fibrinogen, fibrin) deposition, denaturation and subsequent adhesion and activation of blood platelets potentially leading to clot formation and the subsequent activation of coagulation and inflammatory events...
  7. Signaling Mechanism of Platelet Glycoprotein Ib-IX
    Xiaoping Du; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: A receptor molecule on the surface of blood platelets, named glycoprotein Ib-IX, mediates adhesion of blood platelets to blood vessel wall, and is important in ..
  8. Characterization of coagulation factor-platelet interactions: role of FXI
    Owen J McCarty; Fiscal Year: 2013
    ..b>Blood platelets are the essential cellular components of primary hemostasis...
  9. Cytoskeletal Mechanisms of Platelet Formation
    Joseph E Italiano; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Blood platelets play an essential role in hemostasis, as well as in the pathophysiology of thrombosis. The purpose of this proposal is to investigate the cytoskeletal mechanics of platelet formation...
  10. Genetic and Cellular Determinants of Arterial Thrombosis
    Roy L Silverstein; Fiscal Year: 2010
    ..b>Blood platelets play a critical role in initiating arterial thrombi...
  11. Mouse Genes that Regulate Hemostasis and/or Thrombosis
    Thomas J Kunicki; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Blood platelets are the smallest cellular component of the blood and are responsible for the formation of clots in humans and ..
  12. Diagnostic Assay for Thrombocytosis
    Dmitri V Gnatenko; Fiscal Year: 2010
    ..Our PI and collaborators have pioneered studies of the human blood platelets transcriptome1...
  13. Genetic dissection of the platelet thrombohemorrhagic phenotype
    Wadie F Bahou; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Blood platelets are known to regulate clotting (thrombosis) and bleeding (hemorrhage), although only a limited number of ..
  14. Detection of NSCLC-derived mutant RNA in platelets
    Bakhos A Tannous; Fiscal Year: 2013
    ..In this study, we will explore blood platelets as a source for detection of NSCLC predictive/responsive biomarkers.
  15. Amyloid Beta Protein Precursor Influences Cerebral Thrombosis
    William E Van Nostrand; Fiscal Year: 2010
    ..These defining biochemical features of PN2/ABetaPP, coupled with its abundance in brain and in circulating blood platelets, have suggested a role for this protein in regulating thrombosis during episodes of cerebral vascular injury...
  16. Preventing Vein Graft Stenosis in Peripheral Vascular Surgery
    Michael Sobel; Fiscal Year: 2013
    ..We have been studying the function of blood platelets and monocytes in patients undergoing leg bypasses for PAD, by measuring inflammation in their blood before, ..
  17. PLATELET SUFACE ACTIVATION IN HEMOSTASIS AND THROMBOSIS
    SANFORD SHATTIL; Fiscal Year: 1993
    ..Overall, these studies should lead to a more detailed understanding of the platelet membrane events required for normal hemostasis and the role of membrane activation in hemorrhagic and thrombotic disorders...
  18. Platelet-mediated neuroinflammatory response to HIV
    Sanjay B Maggirwar; Fiscal Year: 2013
    ..This notion will be tested by investigating whether the abnormal activation of blood platelets accounts for the observed neurologic deficits in HIV-infected individuals...
  19. Control of lymphatic vessel growth and development by platelets
    Mark L Kahn; Fiscal Year: 2013
    ..These studies reveal a previously un-appreciated non- hemostatic role for circulating blood platelets in mediating vascular separation and an unexpected mechanism by which lymphatic vessel growth and development ..
  20. Regulation of integrin function by divalent cations
    Edward Plow; Fiscal Year: 2004
    DESCRIPTION (provided by applicant) The aggregation of blood platelets, the central cellular event in thrombus formation, is essential to prevent excessive blood loss at sites of injury; but, at the same time, underlies the thrombotic ..
  21. A novel nonthrombogenic vascular circuit
    Garry Southan; Fiscal Year: 2001
    ..The accumulation of blood platelets is quantified by scintillation counting of platelets labeled with indium-111...
  22. Integrated Microfluidic Platelet Activation Assay
    Lawrence Leung; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Blood platelets are a key component of the human body's response to injury, whether from external trauma or internal ailments, including diseases from heart disease to cancer...
  23. Development of Platelet & Coagulation Activation Assays
    RONALD SHEBUSKI; Fiscal Year: 2001
    ..Furthermore, of those patients with suspected AMI, the activation state of blood platelets and procoagulant proteins in the blood is unknown and thus diagnostic criteria of such activation would aid ..
  24. FACTOR VA INTERACTIONS REGULATING PROTHROMBIN ACTIVATION
    Paul Bock; Fiscal Year: 1991
    ..interactions among factor Xa (enzyme), prothrombin (substrate), factor Va (cofactor) and the surfaces of blood platelets are required to achieve the rate of prothrombin activation necessary to support normal hemostasis...
  25. PATHOBIOCHEMISTRY OF BLOOD PLATELET GLYCOSPHINGOLIPIDS
    THEODORE KOERNER; Fiscal Year: 1993
    ..However, very little is known about the GSls of human blood platelets. Thus, we propose, as a long-term objective, to study the pathobiochemistry of platelet GSLs...
  26. CELL BIOLOGY OF MEGAKARYOCYTOPOIESIS
    Robert Leven; Fiscal Year: 1992
    Bone marrow megakaryocytes give rise to blood platelets by fragmentation of their cytoplasm and release of the fragments into the blood stream...
  27. Modulation of integrin function by cytoplasmic signals
    Ulhas Naik; Fiscal Year: 2007
    b>Blood platelets are anucleated cells with unique receptors that respond to blood vessel injury. One of such receptors is integrin alphaIIb-beta3, the fibrinogen receptor...
  28. DIGITAL BLOOD FLOW AND VASCULAR TONE
    JAY COFFMAN; Fiscal Year: 1992
    ..In the chronic drug studies, diaries of he frequency, duration, and severity of vasospastic attacks will be kept and finger blood flows measured in a cool room. Raynaud's phenomenon and if combination therapy is of benefit to patients...
  29. Long Acting Thrombopoietin For Treating Thrombocytopenia
    Daniel Doherty; Fiscal Year: 2002
    ..is a cytokine that stimulates the proliferation and differentiation of megakaryocytes, the precursors to blood platelets. Recombinant human TPO is a promising treatment for stimulating platelet production in patients with ..
  30. Postmenopause CHD risk: Platelet genes & hormone therapy
    Paul Bray; Fiscal Year: 2006
    ..Since blood platelets play a central role in the pathophysiology of MI and stroke, these findings raise questions about the effect ..
  31. ADENOSINE ANALOGS AS CANCER CHEMOTHERAPEUTIC AGENTS
    Robert Parks; Fiscal Year: 1992
    ..2. The effects of adenosine and its analogs on cellular functions of blood platelets, human leukemia cells, and isolated vascular endothelial cells...
  32. RISPERIDONE TREATMENT OF ADOLESCENTS WITH SCHIZOPHRENIA
    Jorge Armenteros; Fiscal Year: 2002
    ..plasma levels to clinical response and side effects, the relationship of serotonin-2 (5-HT2) binding in blood platelets to risperidone treatment response and the effect of risperidone on cognitive functioning...
  33. Silver Encapsulated Magnetic Nanoparticles for Pathogen Inactivation in Platelets
    SEASON WONG; Fiscal Year: 2007
    ..Our preliminary data with bacteria spiked blood platelets and broth have shown that both Gram positive and negative bacteria as well as aerobic and anaerobic bacteria ..
  34. PROTEINS OF BLOOD COAGULATION
    EARL DAVIE; Fiscal Year: 2006
    ..of this research program are to increase our basic knowledge of how plasma proteins interact with circulating blood platelets leading to their activation and shape change at the site of vascular injury...
  35. HOW DOES P24/CD9 FUNCTION IN CELL ADHESION
    Lisa Jennings; Fiscal Year: 1999
    ..Adapted from investigator's abstract) p24/CD9 is an integral membrane protein found on the surface of human blood platelets, lymphoid progenitor cells, mitogen-stimulated T and B cells, endothelial cells and other non-hematologic or ..
  36. MARGINAL BAND SYSTEM OF ERYTHROCYTES
    William Cohen; Fiscal Year: 1980
    ..It is known to be present as well in mammalian blood platelets, primitive mammalian erythrocytes (yolk-sac), invertebrate coelomocytes, and during erythrogenesis in mammals ..
  37. 2009 Cell Biology of Megakaryocytes and Platelets Gordon Research Conference
    LESLIE PARISE; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Blood platelets play a critical role in the prevention of excessive blood loss at sites of tissue injury...
  38. CALCIUM MOVEMENTS IN PLATELET ACTIVATION
    Duncan Haynes; Fiscal Year: 1991
    The processes of Ca2+ influx and release from internal stores are central to the activation and aggression of blood platelets. The processes are triggered to varying extents by physiological activators...
  39. MOLECULAR ANALYSIS OF PLATELET INTEGRIN ACTIVATION
    James Chang; Fiscal Year: 2000
    ..Activation of blood platelets is prerequisite for their full participation in hemostasis and thrombosis (Kroll and Schafer, 1989), and is ..
  40. MOLECULAR BASIS OF THE PLATELET STORAGE LESION
    Therese Wiedmer; Fiscal Year: 2001
    Collection and in vitro storage of blood platelets results in the progressive movement of phosphatidylserine (PS) and phosphatidylethanolamine (PE) from inner to outer leaflet of the platelet plasma membrane...
  41. Platelet transcriptome analysis from small blood volumes
    DMITRI GNATENKO; Fiscal Year: 2005
    Human blood platelets play critical roles in normal hemostatic processes and pathologic conditions such as thrombosis, vascular remodeling, inflammation, and wound repair...
  42. A NOVEL RGD-BINDING MEMBRANE PROTEIN ON BLOOD PLATELETS
    Stephen Lam; Fiscal Year: 1993
    ..These studies will provide fundamental information about a membrane protein likely to be involved in mechanisms underlying platelet adhesion or aggregation...
  43. Ap4A as an Alarmone in Stress Physiology
    RICHARD HILDERMAN; Fiscal Year: 2003
    Adenylated dinucleotides(ApxA)s have been termed alarmones because they are released from blood platelets following stress and modulate gene or enzyme activities...
  44. CRC/PE FOR THE STUDY OF ALZHEIMER'S DISEASE
    Peter Whitehouse; Fiscal Year: 1990
    ..projects are included in the proposal: 1) biochemical assessment of serotonergic and noradrenergic markers in blood platelets, 2) the role of adrenergic and serotonergic systems in the regulation of cortisol secretion and ..
  45. DEVELOPMENT OF A WHOLE-BLOOD PLATELET AGGREGOMETER
    Syed Mohammad; Fiscal Year: 2000
    ..The device will test the functional status of blood platelets and help in identifying abnormalities in these cells...
  46. AFFORDABLE RAPID BACTERIAL DETECTION IN STORED PLATELETS
    Howard Shapiro; Fiscal Year: 2005
    b>Blood platelets collected for transfusion must be stored at room temperature to maximize their survival in a functional state...
  47. PLATELET CALCIUM-BINDING PROTEIN STRUCTURE & FUNCTION
    ELEANOR MC GOWAN; Fiscal Year: 1980
    ..ion concentration and in cyclic nucleotide concentrations are believed to be involved in responses of human blood platelets to various stimuli...
  48. MODERATE ALCOHOL AND THE HEMOSTATIC SYSTEM
    Adam Myers; Fiscal Year: 1999
    DESCRIPTION: Interest in effects of alcohol on blood platelets has grown due to reports that moderate drinking reduces cardiovascular mortality...
  49. CLINICAL CARDIOVASCULAR TOXICITY OF COCAINE
    James Morgan; Fiscal Year: 1993
    ..Project III will study the effects of recreational or habitual cocaine use on human blood platelets and determine whether platelet aggregation could account for the cardiovascular manifestations of cocaine ..
  50. Spinning Disk Confocal Microscope
    Victor Friedrich; Fiscal Year: 2009
    ..cell biology, retinoic acid receptors in breast cancer, nucleic acid uptake by cells, and the formation of blood platelets. The information generated could impact therapies for major human health problems including AIDS, breast ..
  51. Effect of Age on Vein Graft Neointimal Formation
    Brian Cooley; Fiscal Year: 2003
    ..Furthermore, the establishment of an age-associated model of vein grafting will permit age-specific evaluation of new therapeutic avenues for inhibiting neointimal formation. ..
  52. NOVEL APPROACHES TO IMPROVE AND EXTEND PLATELET STORAGE
    Sherrill Slichter; Fiscal Year: 2001
    ....
  53. Low-Cost Digital Imaging System for Evaluating Thrombosis
    Brian Cooley; Fiscal Year: 2008
    ..This imaging methodology may have a capacity for future adaptation to clinical thrombosis imaging. [unreadable] [unreadable] [unreadable]..
  54. Optimizing Cardiovascular Devices Thrombogenicity for Eliminating Anticoagulation
    Danny Bluestein; Fiscal Year: 2009
    ..It is envisioned that it will also facilitate the use of these devices for long term therapy by reducing the need for difficult pharmacological management with anticoagulants, which is mandated for most existing devices. ..
  55. VIRUS PHOTOINACTIVATION--DIMETHYLMETHYLENE BLUE IN RBC
    Stephen Wagner; Fiscal Year: 2004
    ..abstract_text> ..
  56. FASEB Conf. Proteases in Hemostasis and Vascular Biology
    Lawrence Brass; Fiscal Year: 2005
    ..Tissue factor, platelets and coagulation; 8. Regulators of hemostasis; 9. Protease receptors. The keynote lecture will be on gene therapy for disorders of hemostasis delivered by Dr. Katherine High. ..
  57. SNARE PROTEINS IN PLATELET ALPHA-GRANULE SECRETION
    Robert Flaumenhaft; Fiscal Year: 2007
    ..abstract_text> ..
  58. Novel Thrombotic & Inflammatory Mechanisms of Venous Thromboembolism in Elderly
    ANDREW SCOTT WEYRICH; Fiscal Year: 2010
    ..Together these studies will provide new information on how platelets influence the pathogenesis of VTE. ..
  59. Microvascular injury after Subarachnoid Hemorrhage
    Fatima A Sehba; Fiscal Year: 2010
    ....