- Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures
Bin Kuan Chou
Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Cell Res 21:518-29. 2011
..investigated epigenetic and gene expression signatures of multiple postnatal cell types such as fibroblasts and blood cells. Our analysis suggested that newborn cord blood (CB) and adult peripheral blood (PB) mononuclear cells (MNCs) ..
- An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells
Department of Reprogramming Science, Center for iPS Cell Research and Application CiRA, Kyoto University, Kyoto, Japan
Stem Cells 31:458-66. 2013
..We herein report a modified protocol enabling efficient iPSC induction from CD34+ cord blood cells and from peripheral blood isolated from healthy donors using these plasmid vectors...
- miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells
Immune Disease Institute and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
Nat Struct Mol Biol 16:492-8. 2009
..by miR-24 upregulation in in vitro differentiated cells; similar diminished levels are found in primary human blood cells. miR-24-mediated suppression of H2AX renders cells hypersensitive to gamma-irradiation and genotoxic drugs, a ..
- A pilot investigation of visceral fat adiposity and gene expression profile in peripheral blood cells
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
PLoS ONE 7:e47377. 2012
..These changes may affect the gene expression in peripheral blood cells. This study for the first time examined the association between visceral fat adiposity and gene expression ..
- Nanoparticles isolated from blood: a reflection of vesiculability of blood cells during the isolation process
Laboratory of Clinical Biophysics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Int J Nanomedicine 6:2737-48. 2011
..Nanoparticles can also be shed from blood cells during the isolation process, so it is unclear whether nanoparticles found in the isolated material are present ..
- Age-related somatic structural changes in the nuclear genome of human blood cells
Lars A Forsberg
Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Sweden
Am J Hum Genet 90:217-28. 2012
..The recurrent rearrangements uncovered here are candidates for common age-related defects in human blood cells. We anticipate that extension of these results will allow determination of the genetic age of different somatic-..
- Gene expression levels of S100 protein family in blood cells are associated with insulin resistance and inflammation (Peripheral blood S100 mRNAs and metabolic syndrome)
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2 2 B5 Yamada oka, Suita, Osaka 565 0871, Japan
Biochem Biophys Res Commun 433:450-5. 2013
..recently analyzed the association between visceral fat adiposity and the gene expression profile in peripheral blood cells in human subjects and demonstrated the close relationship of visceral fat adiposity and disturbance of ..
- Cost-effective and compact wide-field fluorescent imaging on a cell-phone
UCLA Electrical Engineering Department, Los Angeles, CA 90095, USA
Lab Chip 11:315-22. 2011
..g., blood, urine, sputum or water, and for this end we also demonstrate fluorescent imaging of labeled white-blood cells from whole blood samples, as well as water-borne pathogenic protozoan parasites such as Giardia Lamblia cysts...
- Menstrual blood cells display stem cell-like phenotypic markers and exert neuroprotection following transplantation in experimental stroke
Cesar V Borlongan
Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, Florida 33612, USA
Stem Cells Dev 19:439-52. 2010
..The present neurostructural and behavioral benefits afforded by transplanted menstrual blood-derived cells support their use as a stem cell source for cell therapy in stroke...
- Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome
Judy A Mikovits
Whittemore Peterson Institute, Reno, Nevada, USA
Virulence 1:386-90. 2010
..We advocate the use of more than one type of assay in order to determine the frequency of XMRV infection in patient cohorts in future studies of the relevance of XMRV to human disease...
- Blood cells of Drosophila: cell lineages and role in host defence
Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, 67084 Strasbourg, France
Curr Opin Immunol 16:10-5. 2004
..Crystal cells and lamellocytes have no clear mammalian homologues. Research into the molecular mechanisms that underlie the various immune functions of Drosophila blood cells, such as non-self recognition, is now taking wing.
- Altered immune phenotype in peripheral blood cells of patients with scleroderma-associated pulmonary hypertension
Michael G Risbano
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Aurora, USA
Clin Transl Sci 3:210-8. 2010
..Differences exist in the expression of inflammatory and immune-related genes in peripheral blood cells from patients with scleroderma-related pulmonary hypertension compared to those with normal pulmonary artery ..
- In vivo formation of gamma-H2AX and 53BP1 DNA repair foci in blood cells after radioiodine therapy of differentiated thyroid cancer
Department of Nuclear Medicine, University of Wurzburg, Wurzburg, Germany
J Nucl Med 51:1318-25. 2010
- Biology of peripheral blood cells in obstructive sleep apnea--the tip of the iceberg
Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
Arch Physiol Biochem 114:244-54. 2008
..These facilitate increased interactions of blood cells with endothelial cells, resulting in endothelial cell injury and dysfunction...
- Low-dose radiation (LDR) induces hematopoietic hormesis: LDR-induced mobilization of hematopoietic progenitor cells into peripheral blood circulation
Department of Hematology and Oncology, First University Hospital, PR China
Exp Hematol 32:1088-96. 2004
..The aim of this study was to investigate the stimulating effect of low-dose radiation (LDR) on bone marrow hematopoietic progenitor cell (HPC) proliferation and peripheral blood mobilization...
- Expression and activation by Epstein Barr virus of human endogenous retroviruses-W in blood cells and astrocytes: inference for multiple sclerosis
Department of Biomedical Sciences and Centre of Excellence for Biotechnology Development and Biodiversity Research, University of Sassari, Sassari, Italy
PLoS ONE 7:e44991. 2012
- Origin of blood cells and HSC production in the embryo
Cancer Research UK Stem Cell Hematopoiesis Group, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
Trends Immunol 33:215-23. 2012
..A better understanding of HSC development during ontogeny is essential to develop new strategies to amplify HSCs or to generate them from embryonic stem cells or by somatic cell reprogramming...
- Geldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat-shock protein 90 kDa after exposure to ionizing radiation
Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
Radiat Res 176:333-45. 2011
..Hsp90 inhibitors such as 17-DMAG may prove useful with radiation-based cancer therapy as well as for general radioprotection...
- Yolk-sac hematopoiesis: the first blood cells of mouse and man
University of Rochester, Department of Pediatrics and Cancer Center, Rochester, NY 14642, USA
Exp Hematol 29:927-36. 2001
..To review the process of blood-cell formation in the murine and human yolk sac...
- Transcriptional profiling of peripheral blood cells in clinical pharmacogenomic studies
Michael E Burczynski
Wyeth Research, Pharmacogenomic Biomarkers, Biomarker Laboratory, 500 Arcola Road, Collegeville, PA 19426, USA
Pharmacogenomics 7:187-202. 2006
..The hypothesis is that the circulating blood cells monitor the physiological state of the organism and alter their transcriptome in response to this surveillance...
- Differential localization of myosin-II isozymes in human cultured cells and blood cells
Department of Cell Biology and Anatomy, Johns Hopkins Medical School, Baltimore, MD 21205 2196
J Cell Sci 107:3077-90. 1994
..directly labeled with fluorescent dyes to localize these myosin-II isozymes in HeLa cells, melanoma cells and blood cells. Both antibodies react strongly with myosin-II isozymes in HeLa cells, melanoma cells and blood eosinophils, ..
- Increased acid sphingomyelinase activity in peripheral blood cells of acutely intoxicated patients with alcohol dependence
Department of Psychiatry and Psychotherapy, University of Erlangen, Erlangen, Germany
Alcohol Clin Exp Res 34:46-50. 2010
..Ethanol-induced activation of ASM has been observed in different cell culture systems, thus raising the question about the effect of alcohol intoxication in human subjects on ASM activity in vivo...
- Both primitive and definitive blood cells are derived from Flk-1+ mesoderm
Jesse J Lugus
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Blood 113:563-6. 2009
..However, this concept has not been completely proven, especially for the origin of blood cells. Using either Flk1(+/Cre);Rosa26R-EYFP or Flk1(+/Cre);Rosa26R-LacZ mice, we permanently marked Flk-1(+) cells ..
- Diminished expression of complement regulatory proteins on peripheral blood cells from systemic lupus erythematosus patients
Ana Paula Alegretti
Serviço de Patologia Clínica, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, 2 andar, 90035 903 Porto Alegre, RS, Brazil
Clin Dev Immunol 2012:725684. 2012
..The aim of this study was to evaluate the Creg expression on peripheral blood cells from SLE patients and its association with cytopenia and disease activity...
- Plasma malondialdehyde levels and CXCR4 expression in peripheral blood cells of breast cancer patients
Juliana Laino do Val Carneiro
Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Campus Universitario, CEP 86051 970 Londrina, PR, Brazil
J Cancer Res Clin Oncol 135:997-1004. 2009
..This study examined CXCR4 mRNA expression in peripheral blood cells and malondialdehyde (MDA) in plasma from blood donors and breast cancer patients.
- Characterization of the expression of HTm4 (MS4A3), a cell cycle regulator, in human peripheral blood cells and normal and malignant tissues
Jeffery L Kutok
Harvard Medical School, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
J Cell Mol Med 15:86-93. 2011
..Here we describe the expression pattern of HTm4 in peripheral blood cells using gene expression microarray technology, and in normal foetal and adult human tissues, as well as adult ..
- Differential serotonin transport is linked to the rh5-HTTLPR in peripheral blood cells
Y S Singh
Department of Chemistry, Pennsylvania State University, University Park, PA, USA
Transl Psychiatry 2:e77. 2012
..We studied the serotonin system as it relates to the 5-HTTLPR in rhesus peripheral blood cells. Sequencing of the rh5-HTTLPR revealed a 23-bp insertion, which is somewhat longer than originally reported...
- Molecular profiling of peripheral blood cells from patients with polycythemia vera and related neoplasms: identification of deregulated genes of significance for inflammation and immune surveillance
Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
Leuk Res 36:1387-92. 2012
..Our findings may reflect chronic inflammation to be of pathogenetic importance for the progression of these neoplasms toward the myelofibrotic end-stage and may also account for the increased frequency of second cancer in these diseases...
- Pathway analysis in blood cells of pigs infected with classical swine fever virus: comparison of pigs that develop a chronic form of infection or recover
Livestock Research of Wageningen University and Research Centre, P O Box 65, 8200 AB, Lelystad, The Netherlands
Arch Virol 158:325-39. 2013
..Using whole-genome microarrays, time-dependent changes in gene expression were recorded in blood cells of chronically diseased pigs and pigs that recovered...
- Morphological and functional characterization of leech circulating blood cells: role in immunity and neural repair
Laboratoire de Neuroimmunologie et Neurochimie Evolutive, CNRS, FRE3249, Universite de Lille 1, Villeneuve d Ascq, France
Cell Mol Life Sci 69:1717-31. 2012
..The morphology and the function of leech blood cells are reported here...
- Identification of inducible nitric oxide synthase in peripheral blood cells as a mediator of myocardial ischemia/reperfusion injury
Institute of Molecular Cardiology, University of Louisville, 550 S Jackson Street ACB Bldg, 3rd Floor, Louisville, KY 40202, USA
Basic Res Cardiol 107:253. 2012
..To test this hypothesis, we created chimeric mice with iNOS-deficient peripheral blood cells by transplanting iNOS knockout (KO) bone marrow in wild-type (WT) mice after lethal irradiation...
- The effect of melatonin on peripheral blood cells during total body irradiation in rats
Department of Radiation Oncology, Medical School of Ataturk University, Erzurum, Turkey
Biol Pharm Bull 25:656-7. 2002
..radioprotective effects of pharmacological doses of melatonin in total body irradiated rat's peripheral blood cells. Forty adult rats were divided into 4 equal groups...
- Radiation-induced micro-RNA expression changes in peripheral blood cells of radiotherapy patients
Center for Radiological Research, Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA
Int J Radiat Oncol Biol Phys 80:549-57. 2011
..Our in vivo study measured miRNA and gene expression changes in human blood cells in response to ionizing radiation, to develop miRNA signatures that can be used as biomarkers for radiation ..
- Mass spectrometric analysis of lipid species of human circulating blood cells
Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
Biochim Biophys Acta 1781:655-64. 2008
..Here we compared lipid species in monocytes, lymphocytes, granulocytes, platelets and red blood cells (RBC) of healthy volunteers using electrospray ionization tandem mass spectrometry and detected striking ..
- Transcriptional regulation of eater gene expression in Drosophila blood cells
Paul T Kroeger
Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
Genesis 50:41-9. 2012
..This suggests that Serpent regulates eater expression by binding these GATA sites, which was confirmed by gel shift analysis. These analyses allowed us to use eater-Gal4 to force plasmatocyte to lamellocyte differentiation...
- The oxidative status of blood cells in a murine model of graft-versus-host disease
Department of Hematology, Hadassah University Hospital, Ein Kerem, POB 12000, Jerusalem, 91120, Israel
Ann Hematol 86:753-8. 2007
We studied the oxidative status of red and white blood cells during the development of graft vs host disease (GVHD) as well as the effects of treatment with antioxidants, both in vitro and in vivo...
- The utility of gene expression in blood cells for diagnosing neuropsychiatric disorders
Christopher H Woelk
Department of Medicine, University of California San Diego, La Jolla, California, USA
Int Rev Neurobiol 101:41-63. 2011
Objective diagnostic tools are required for neuropsychiatric disorders. Gene expression in blood cells may provide such a tool and has already been used to construct classifiers capable of diagnosing many human diseases...
- Gene profiling identifies secreted protein transcripts from peripheral blood cells in coronary artery disease
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ont, Canada M5G 1L5
J Mol Cell Cardiol 35:993-8. 2003
- Profiling of length heteroplasmies in the human mitochondrial DNA control regions from blood cells in the Korean population
Myung Geun Shin
Department of Laboratory Medicine, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Hwasun, South Korea
Electrophoresis 27:1331-40. 2006
The length heteroplasmies in the hypervariable (HV) regions of mitochondrial DNA (mtDNA) from blood cells were examined in 57 healthy Korean donors...
- Microfluidic structures for flow cytometric analysis of hydrodynamically focussed blood cells fabricated by ultraprecision micromachining
Physikalisch Technische Bundesanstalt, Abbestr 2 12, 10587, Berlin, Germany
Lab Chip 9:972-81. 2009
..microfluidic structures with integrated optical fibers, mirrors and electrodes for flow cytometric analysis of blood cells. Ultraprecision milling technique was used to fabricate different flow cells featuring single-stage and two-..
- Integrated protein network and microarray analysis to identify potential biomarkers after myocardial infarction
Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, 120 route d Arlon, 1150, Luxembourg, Luxembourg
Funct Integr Genomics 10:329-37. 2010
..in MI patients, we designed an approach combining protein interaction networks and microarray analysis of blood cells. Blood samples for RNA and protein analysis were taken from 127 acute MI patients...
- Supplementation with a fish oil-enriched, high-protein medical food leads to rapid incorporation of EPA into white blood cells and modulates immune responses within one week in healthy men and women
Nutricia Advanced Medical Nutrition, Danone Research Center for Specialized Nutrition, Wageningen 6704PH, The Netherlands
J Nutr 141:964-70. 2011
..regarding short-term incorporation, the present study investigated the incorporation of EPA and DHA into white blood cells (WBC) at different time points during 1 wk of supplementation with a medical food, which is high in protein and ..
- Immunomodulatory effect of vitamin C on intracytoplasmic cytokine production in neonatal cord blood cells
Department of Pediatrics, University of Lubeck Medical School, Lubeck, Germany
Neonatology 91:54-60. 2007
..cytokines such as interleukin (IL)-6 and tumor necrosis factor alpha (TNF-alpha) in adult whole blood cells in vitro...
- Effect of Er:YAG and Diode lasers on the adhesion of blood components and on the morphology of irradiated root surfaces
Leticia Helena Theodoro
Department of Periodontology, Araraquara Dental School, State University of Sao Paulo, Araraquara, Sao Paulo, Brazil
J Periodontal Res 41:381-90. 2006
..94 microm) and GaAlAs Diode (808 nm) lasers and the effects on the morphology of irradiated root surfaces...
- Gene expression signatures in peripheral blood cells from Japanese women exposed to environmental cadmium
Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushima 770 8503, Japan
Toxicology 257:25-32. 2009
..was to examine the effects of environmental cadmium (Cd) exposure on the gene expression profile of peripheral blood cells, using an original oligoDNA microarray...
- Diprotin A infusion into nonobese diabetic/severe combined immunodeficiency mice markedly enhances engraftment of human mobilized CD34+ peripheral blood cells
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1456, USA
Stem Cells Dev 16:361-70. 2007
..at the time of transplant of human granulocyte colony-stimulating factor (G-CSF) mobilized CD34(+) peripheral blood cells (CD34(+) PBCs) results in a >3.4-fold enhancement of engraftment of human cells...
- Tissue factor/TFPI and blood cells
HERG, Department of Medical Biology, Faculty of Health Sciences and MabCent SFI, University of Tromsø, 9037 Tromsø, Norway
Thromb Res 129:274-8. 2012
..in extravascular sites exclusively has recently been challenged by several reports on TF expression in various blood cells. The latter arena has unfortunately been marred by many contradictions, apparently related to inferior tools ..
- Methylation-related mutations in the BRCA1 promoter in peripheral blood cells from cancer-free women
DNA Repair and Apoptosis Section, Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, MBC 03, PO Box 3354, Riyadh 11211, Saudi Arabia
Int J Oncol 39:129-35. 2011
..the epigenetic modifications of the breast cancer type 1 susceptibility gene (BRCA1) in breast tissues and blood cells derived from women with breast cancer and women without breast cancer...
- Direct sensing of systemic and nutritional signals by haematopoietic progenitors in Drosophila
Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California 90095, USA
Nat Cell Biol 14:394-400. 2012
..of the primary lobe of the lymph gland called the medullary zone contains these progenitors, and maturing blood cells are found juxtaposed in a peripheral region designated the cortical zone...
- Gene expression profile of Ci-VSP in juveniles and adult blood cells of ascidian
Department of Nanobiology, Graduate School of Advanced Integration Science, Chiba University, Yayoi cho 1 33, Inage Ku, Chiba 263 8522, Japan
Gene Expr Patterns 11:233-8. 2011
..Whole mount in situ hybridization showed that Ci-VSP is expressed in cells of the stomach, intestine and blood cells of 2- to 3-week-old juveniles...
- Receptor mediated binding of the fibrinolytic components, plasminogen and urokinase, to peripheral blood cells
L A Miles
Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037
Thromb Haemost 58:936-42. 1987
..This study assesses the interaction of these fibrinolytic proteins with circulating human blood cells. Plasminogen bound minimally to red cells but bound saturably and reversibly to monocytes, granulocytes and ..
- Determinants of atherosclerosis susceptibility in the C3H and C57BL/6 mouse model: evidence for involvement of endothelial cells but not blood cells or cholesterol metabolism
Department of Medicine, University of California, Los Angeles, CA 90095 1679, USA
Circ Res 86:1078-84. 2000
..These data provide strong evidence that endothelial cells, but not monocytes or plasma lipid levels, account for the difference in susceptibility to atherosclerosis between the 2 mouse strains...
- Telomere length in fibroblasts and blood cells from healthy centenarians
Istituto di Genetica Biochimica ed Evoluzionistica of CNR, via Abbiategrasso 207, Pavia, 27100, Italy
Exp Cell Res 248:234-42. 1999
..In blood cells from various individuals, the expected inverse correlation between mean TRF length and donor age was found...
- N-acetylcysteine amide (AD4) attenuates oxidative stress in beta-thalassemia blood cells
Department of Hematology, Hadassah Hebrew University Medical Center, Jerusalem
Biochim Biophys Acta 1780:249-55. 2008
..Using flow-cytometry, we showed that in vitro treatment of blood cells from beta-thalassemic patients with AD4 elevated the reduced glutathione (GSH) content of red blood cells (RBC),..
- Relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population
Division of Gastroenterology and Nutrition and EGID Centre, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 5:e12204. 2010
..The aim of this study was to analyze the relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population.
- A germline GFP transgenic axolotl and its use to track cell fate: dual origin of the fin mesenchyme during development and the fate of blood cells during regeneration
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Dev Biol 290:386-97. 2006
..During tail regeneration, we do not observe GFP+ cells contributing to muscle or nerve, suggesting that during tail regeneration blood stem cells do not undergo significant plasticity...
- Gene expression signature in peripheral blood cells from medical students exposed to chronic psychological stress
Department of Stress Science, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima, Japan
Biol Psychol 76:147-55. 2007
..Of the 24 genes, real-time PCR validated changes in mRNA levels of 10 (PLCB2, CSF3R, ARHGEF1, DPYD, CTNNB1, PPP3CA, POLM, IRF3, TP53, and CCNI). The identified genes may be useful to assess chronic psychological stress response...
- Structural and functional characterisation of the blood cells of the bivalve mollusc, Scrobicularia plana
E C Wootton
Marine Biological Association, Citadel Hill, PL1 2PB Plymouth, UK
Fish Shellfish Immunol 15:249-62. 2003
Light and electron microscopical studies were carried out in order to characterise the blood cells of the bivalve mollusc, Scrobicularia plana...
- Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study
M D Anderson Cancer Center, Houston, Texas, USA
Blood 99:1928-37. 2002
..Orally administered imatinib is an effective and well-tolerated treatment for patients with CML in accelerated phase. A daily dose of 600 mg is more effective than 400 mg, with similar toxicity...
- Flow cytometric measurement of microparticles: pitfalls and protocol modifications
Mona D Shah
Baylor College opf Medicine, Texas Children s Cancer Center and Hematology Service, Texas Children s Hospital, Houston, Texas 77030, USA
Platelets 19:365-72. 2008
..These results illustrate the need to standardize assay protocols in order to obtain consistent measurements. Our studies further optimize sample preparation for microparticle detection...
- Influence of root-surface conditioning with acid and chelating agents on clot stabilization
Fabio Renato Manzolli Leite
Department of Semilogy and Clinics, School of Dentistry, Federal University of Pelotas UFPel Pelotas, Rio Grande do Sul, Brazil
Quintessence Int 41:341-9. 2010
..To compare the adhesion and maturation of blood components on chemically conditioned root surfaces...
- Precision of pyrosequencing assay to measure LINE-1 methylation in colon cancer, normal colonic mucosa, and peripheral blood cells
Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney St, Room JF 215C, Boston, MA 02115, USA
J Mol Diagn 12:177-83. 2010
..In addition, LINE-1 hypomethylation in blood cells has been associated with colorectal adenoma risk, and LINE-1 hypomethylation in colorectal cancer is related ..
- The inflammation-fibrosis link? A Jekyll and Hyde role for blood cells during wound repair
Brian M Stramer
Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, UK
J Invest Dermatol 127:1009-17. 2007
- Hematopoietic cell types: prototype for a revised cell ontology
Alexander D Diehl
The Jackson Laboratory, Bar Harbor, ME 04609, USA
J Biomed Inform 44:75-9. 2011
..The methods and improvements to the CL in this area represent a paradigm for improvement of the entire ontology over time...
- The next generation of burns treatment: intelligent films and matrix, controlled enzymatic debridement, and adult stem cells
Banco de Tejidos, Hospital de Quemados, CABA, Argentina
Transplant Proc 42:345-9. 2010
- Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program
Leeds Institute for Molecular Medicine, University of Leeds, Leeds, United Kingdom
Blood 114:299-309. 2009
..Our experiments therefore demonstrate how individual transcription factors function in a differentiation stage-specific manner to differentially affect the initiation versus maintenance of a developmental program...
- Generation of induced pluripotent stem cells from human blood
Yuin Han Loh
Department of Medicine, Division of Pediatric Hematology Oncology, Children s Hospital Boston, Dana Farber Cancer Institute, Boston, MA 02115, USA
Blood 113:5476-9. 2009
..Here, we describe the derivation of induced pluripotent stem cells from CD34+ mobilized human peripheral blood cells using retroviral transduction of OCT4/SOX2/KLF4/MYC...
- Comparison of different isolation techniques prior gene expression profiling of blood derived cells: impact on physiological responses, on overall expression and the role of different cell types
Molecular Tumor Biology and Tumor Immunology, Center for Internal Medicine, University of Cologne, Cologne, Germany
Pharmacogenomics J 4:193-207. 2004
..Gene expression patterns in peripheral blood cells greatly depend on temporal and interindividual variations...
- Release of anandamide from blood cells
Institute of Clinical Chemistry, Hospital of the University of Munich, Munich, Germany
Clin Chem Lab Med 44:488-91. 2006
..Since this might be caused by pre-analytical variables, we investigated the impact of different sample handling conditions on measured plasma anandamide concentrations...
- Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia
Division of Immunology, Paul Ehrlich Institut, Paul Ehrlich Str 51 59, D 63225 Langen, Germany
Blood 108:3253-61. 2006
..In conclusion, our data identify a new effect of direct IFN-alpha/beta stimulation of lymphocytes that profoundly affects lymphocyte redistribution...
- Rhythms in human bone marrow and blood cells
Department of Oncology, Haukeland Hospital, University of Bergen, Norway
Chronobiol Int 19:101-27. 2002
- Circulating microparticles: pathophysiology and clinical implications
Irish Blood Transfusion Service, James s Street, Dublin 8, Ireland
Blood Rev 21:157-71. 2007
Microparticles (MP) derived from vascular endothelium or circulating blood cells circulate in the peripheral blood...
- Effects of age, gender, and immunosuppressive agents on in vivo toll-like receptor pathway responses
Department of Immunology, University of Manchester, Manchester, UK
Hum Immunol 71:372-6. 2010
..Furthermore, an understanding the effects of immunosuppressive agents on TLR-pathway activity should allow more focused therapy for autoimmune disorders...
- Nucleotide receptors: an emerging family of regulatory molecules in blood cells
F Di Virgilio
Department of Experimental and Diagnostic Medicine, Section of General Pathology and Medical Genetics, and Center of Biotechnology, University of Ferrara, Ferrara, Italy
Blood 97:587-600. 2001
..lysosomal constituents, and generation of reactive oxygen or nitrogen species are elicited upon stimulation of blood cells with extracellular adenosine triphosphate (ATP)...
- Telomere length in haemopoietic stem cells can be determined from that of mononuclear blood cells or whole blood
Jennette A Sakoff
Department of Medical Oncology, Newcastle Mater Misericordiae Hospital, Newcastle, Locked Bag No 7, Hunter Region Mail Center, 2310, NSW, Australia
Leuk Lymphoma 43:2017-20. 2002
..83, P < 0.001). Thus, telomere length in haemopoietic stem cells can be determined from that of whole or fractionated PB in future studies of haematological disorders...
- Expression of adenosine triphosphate-binding cassette (ABC) drug transporters in peripheral blood cells: relevance for physiology and pharmacotherapy
Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, Ernst Moritz Arndt University, Greifswald, Germany
Clin Pharmacokinet 46:449-70. 2007
..g. in the brain or the gastrointestinal tract). In this context, peripheral blood cells have also been found to express several ABC-type transporters...
- Role of polyamines derived from arginine in differentiation and proliferation of human blood cells
Department of Molecular Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamasaki, Noda, Chiba 278 8510, Japan
Biol Pharm Bull 29:234-9. 2006
..nitric oxide (NO), creatine, and agmatine and is essential for the differentiation and proliferation of blood cells, although the precise biological role of L-arginine is unclear...
- The serine protease Sp7 is expressed in blood cells and regulates the melanization reaction in Drosophila
Department of Experimental Medical Science and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, BMC B13, Klinikgatan 26, 22184 Lund, Sweden
Biochem Biophys Res Commun 338:1075-82. 2005
..We show that Sp7 is constitutively expressed in blood cells during embryonic and larval stages. Silencing of the gene impairs the melanization reaction upon injury...
- Isolation of rare tumor cells from blood cells with buoyant immuno-microbubbles
Moores Cancer Center, University of California San Diego, La Jolla, California, USA
PLoS ONE 8:e58017. 2013
..Here we report a novel method for isolation of rare tumor cells from excess of blood cells using gas-filled buoyant immuno-microbubbles (MBs)...
- Differential expression of wild-type and mutant NMMHC-IIA polypeptides in blood cells suggests cell-specific regulation mechanisms in MYH9 disorders
Department of Hemostasis and Thrombosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
Blood 111:3015-23. 2008
..We examined the expression of mutant NMMHC-IIA polypeptide in peripheral blood cells from patients with MYH9 5770delG and 5818delG mutations...
- [(3)H]Nicotine binding in peripheral blood cells of smokers is correlated with the number of cigarettes smoked per day
Department of Psychiatry, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
Neuropharmacology 39:2818-29. 2000
..Expression of both mRNA and protein in lymphocytes and PMN, for a subset of nicotinic receptor subunits, suggests that these cell types contain both alpha4beta2 and alpha3beta4 receptors...
- Xenotropic murine leukaemia virus-related virus is not found in peripheral blood cells from treatment-naive human immunodeficiency virus-positive patients
Virology Unit, Pisa University Hospital, Pisa, Italy
Clin Microbiol Infect 18:184-8. 2012
..Using nested PCR and single-step TaqMan real-time PCR, both designed on the XMRV gag gene, we could not find any positive samples. These findings add to the growing amount of scepticism regarding XMRV...
- Expression profiling of circulating non-red blood cells in embryonic blood
Brendan A S McIntyre
Laboratory for Early Embryogenesis, RIKEN Center for Developmental Biology, Kobe, Hyogo 650 0047, Japan
BMC Dev Biol 8:21. 2008
..Using chicken as a model system, we have isolated an enriched pool of circulating non red blood cells (nRBCs) from E4 and E6 embryos; a transition period when definitive hematopoietic lineages are being specified ..
- Dendritic cell-associated lectin-1: a novel dendritic cell-associated, C-type lectin-like molecule enhances T cell secretion of IL-4
Elizabeth J Ryan
Regional Primate Research Center, Box 357330, University of Washington, Seattle, WA 98195, USA
J Immunol 169:5638-48. 2002
..Therefore, the function of DCAL-1 on DCs and B cells may act as a T cell costimulatory molecule, which skews CD4(+) T cells toward a Th2 response by enhancing their secretion of IL-4...
- Functional eicosanoid test and typing (FET) of peripheral blood cells in eicosanoids related diseases
Medizinische Klinik III mit Poliklinik, Abteilung für Allergologie, Friedrich Alexander Universitat Erlangen Nurnberg, Krankenhausstr 29, D 91054 Erlangen, Germany
J Physiol Pharmacol 56:103-18. 2005
Monitoring of eicosanoid synthesis in peripheral blood cells has significant potential for improving the diagnosis and therapy of many human diseases...
- Toward personalized cell therapies: autologous menstrual blood cells for stroke
Maria Carolina O Rodrigues
Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, Tampa, FL 33612, USA
J Biomed Biotechnol 2011:194720. 2011
..We here propose the use of autologous menstrual blood cells in the restorative treatment of the subacute phase of stroke...
- Hemodynamic measurements from individual blood cells in early mammalian embryos with Doppler swept source OCT
Irina V Larina
Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77584, USA
Opt Lett 34:986-8. 2009
..5 day embryo just a few hours after the beginning of a heartbeat. Our data show that individual circulating blood cells can be visualized with structural SS-OCT, and using Doppler SS-OCT the velocity of single moving blood cells ..
- Oxidative DNA damage in peripheral blood cells in type 2 diabetes mellitus: higher vulnerability of polymorphonuclear leukocytes
Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Mutat Res 529:129-33. 2003
..and DNA base oxidation, measured as FPG (formamidopyrimidine DNA glycosylase)-sensitive sites, in peripheral blood cells (PBC) from type 2 diabetes patients and healthy controls...
- Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells
Elizabeth A DiBlasio-Smith
Department of Biological Technologies, Wyeth Research, 35 CambridgePark Drive, Cambridge, MA 02140, USA
J Transl Med 6:59. 2008
..Anti-atherosclerotic effects of synthetic LXR agonists in murine models suggest clinical utility for such compounds...
- Effects of acetaminophen on constitutive and inducible prostanoid biosynthesis in human blood cells
Maria G Sciulli
Centre of Excellence on Aging, G D Annunzio University, School of Medicine, Chieti, Italy
Br J Pharmacol 138:634-41. 2003
- Drug treatment of Alzheimer's disease patients leads to expression changes in peripheral blood cells
Margaret A Calciano
ExonHit Therapeutics Inc, Gaithersburg, MD, USA
Alzheimers Dement 6:386-93. 2010
..The goal of this study was to determine the feasibility of discovering biomarkers specific for the treatment of Alzheimer's disease...
- [Sharp changes in the copy number of mtDNA and its transcription in the blood cells of X-ray irradiated mice are observed, and mtDNA fragments appear in the blood serum]
E V Evdokimovskiĭ
Radiats Biol Radioecol 47:402-7. 2007
..in the number of mitochondrial DNA (mtDNA) copies and alterations in its transcription were followed in the blood cells of mice after their exposure to X-rays; also, extracellular mtDNA fragments were registered in the blood serum ..
- Comparison of the DNA methylation profiles of human peripheral blood cells and transformed B-lymphocytes
Yan V Sun
Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights 4629, Ann Arbor, MI 48109, USA
Hum Genet 127:651-8. 2010
..One was extracted from peripheral blood cells (PBC) and the other from transformed B-lymphocytes (TBL)...
- The effect of VEGF on blood vessels and blood cells during Xenopus development
Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita 565 0871, Japan
Biochem Biophys Res Commun 344:339-45. 2006
..of vasculogenesis in the posterior portion of the blood island, with excessive production of endothelial cells at the expense of blood cells, and that the anterior and posterior portions of the VBI may have distinct characteristics.
- Profile of blood cells and inflammatory mediators in periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome
Kelly L Brown
Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
BMC Pediatr 10:65. 2010
This study aimed to profile levels of blood cells and serum cytokines during afebrile and febrile phases of periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome to advance pathophysiological understanding of ..
- Inhibition of chemiluminescence by carvedilol in the cell-free system, whole human blood and blood cells
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic
Scand J Clin Lab Invest 65:55-64. 2005
..This could be the result of the supportive effect of serotonin liberated from platelets by A23187...
- Differential interaction of magnetic nanoparticles with tumor cells and peripheral blood cells
J H Clement
Department of Internal Medicine II, Friedrich Schiller University Jena, Erlanger Allee 101, 07740, Jena, Germany
J Cancer Res Clin Oncol 132:287-92. 2006
..The separation of tumor cells from healthy cells is a vital problem in oncology and hematology, especially from peripheral blood. Magnetic assisted cell sorting (MACS) is a possibility to fulfill these needs...
- Detection of the 4977 bp deletion of mitochondrial DNA in different human blood cells
S A Mohamed
Department of Legal Medicine, Medical University of Luebeck, Kahlhorststrasse 31 35, Luebeck 23562, Germany
Exp Gerontol 39:181-8. 2004
..Differences of the accumulation pattern may be due to actual individual living behaviour or environmental factors...
- Morphologic and cytochemical characteristics of blood cells of juvenile loggerhead sea turtles (Caretta caretta)
A B Casal
Department of Morphology, Unit of Histology and Pathology, Veterinary Faculty, University of Las Palmas de Gran Canaria ULPGC, Trasmontana s n, 35416 Arucas, Las Palmas, Spain
Res Vet Sci 82:158-65. 2007
A morphologic classification based on the cytochemical characteristics of blood cells of 35 juvenile loggerhead sea turtles (Caretta caretta) is described...
- In vivo effects of myeloablative alkylator therapy on survival and differentiation of MGMTP140K-transduced human G-CSF-mobilized peripheral blood cells
Herman B Wells Center for Pediatric Research, Department of Pediatrics, The Riley Hospital for Children, 1044 West Walnut Street R4 468, Indianapolis, IN 46202 5525, USA
Mol Ther 13:1016-26. 2006
..These data suggest that improved strategies to optimize repair of DNA damage in primitive human hematopoietic cells are needed when using high-intensity anti-cancer therapy...
- A novel monolayer cell line derived from human umbilical cord blood cells shows high sensitivity to measles virus
Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
J Gen Virol 88:1565-7. 2007
..Thus, COBL-a cells should prove very valuable for both epidemiological and basic studies of MeV...