blood cells

Summary

Top Publications

  1. pmc Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures
    Bin Kuan Chou
    Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cell Res 21:518-29. 2011
  2. ncbi An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells
    Keisuke Okita
    Department of Reprogramming Science, Center for iPS Cell Research and Application CiRA, Kyoto University, Kyoto, Japan
    Stem Cells 31:458-66. 2013
  3. pmc miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells
    Ashish Lal
    Immune Disease Institute and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Struct Mol Biol 16:492-8. 2009
  4. pmc A pilot investigation of visceral fat adiposity and gene expression profile in peripheral blood cells
    Masaya Yamaoka
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    PLoS ONE 7:e47377. 2012
  5. pmc Nanoparticles isolated from blood: a reflection of vesiculability of blood cells during the isolation process
    Vid Sustar
    Laboratory of Clinical Biophysics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Int J Nanomedicine 6:2737-48. 2011
  6. pmc Age-related somatic structural changes in the nuclear genome of human blood cells
    Lars A Forsberg
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Sweden
    Am J Hum Genet 90:217-28. 2012
  7. ncbi Gene expression levels of S100 protein family in blood cells are associated with insulin resistance and inflammation (Peripheral blood S100 mRNAs and metabolic syndrome)
    Masaya Yamaoka
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2 2 B5 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 433:450-5. 2013
  8. pmc Cost-effective and compact wide-field fluorescent imaging on a cell-phone
    Hongying Zhu
    UCLA Electrical Engineering Department, Los Angeles, CA 90095, USA
    Lab Chip 11:315-22. 2011
  9. pmc Menstrual blood cells display stem cell-like phenotypic markers and exert neuroprotection following transplantation in experimental stroke
    Cesar V Borlongan
    Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Stem Cells Dev 19:439-52. 2010
  10. pmc Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome
    Judy A Mikovits
    Whittemore Peterson Institute, Reno, Nevada, USA
    Virulence 1:386-90. 2010

Research Grants

Detail Information

Publications265 found, 100 shown here

  1. pmc Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures
    Bin Kuan Chou
    Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cell Res 21:518-29. 2011
    ..investigated epigenetic and gene expression signatures of multiple postnatal cell types such as fibroblasts and blood cells. Our analysis suggested that newborn cord blood (CB) and adult peripheral blood (PB) mononuclear cells (MNCs) ..
  2. ncbi An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells
    Keisuke Okita
    Department of Reprogramming Science, Center for iPS Cell Research and Application CiRA, Kyoto University, Kyoto, Japan
    Stem Cells 31:458-66. 2013
    ..We herein report a modified protocol enabling efficient iPSC induction from CD34+ cord blood cells and from peripheral blood isolated from healthy donors using these plasmid vectors...
  3. pmc miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells
    Ashish Lal
    Immune Disease Institute and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Struct Mol Biol 16:492-8. 2009
    ..by miR-24 upregulation in in vitro differentiated cells; similar diminished levels are found in primary human blood cells. miR-24-mediated suppression of H2AX renders cells hypersensitive to gamma-irradiation and genotoxic drugs, a ..
  4. pmc A pilot investigation of visceral fat adiposity and gene expression profile in peripheral blood cells
    Masaya Yamaoka
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    PLoS ONE 7:e47377. 2012
    ..These changes may affect the gene expression in peripheral blood cells. This study for the first time examined the association between visceral fat adiposity and gene expression ..
  5. pmc Nanoparticles isolated from blood: a reflection of vesiculability of blood cells during the isolation process
    Vid Sustar
    Laboratory of Clinical Biophysics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Int J Nanomedicine 6:2737-48. 2011
    ..Nanoparticles can also be shed from blood cells during the isolation process, so it is unclear whether nanoparticles found in the isolated material are present ..
  6. pmc Age-related somatic structural changes in the nuclear genome of human blood cells
    Lars A Forsberg
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Sweden
    Am J Hum Genet 90:217-28. 2012
    ..The recurrent rearrangements uncovered here are candidates for common age-related defects in human blood cells. We anticipate that extension of these results will allow determination of the genetic age of different somatic-..
  7. ncbi Gene expression levels of S100 protein family in blood cells are associated with insulin resistance and inflammation (Peripheral blood S100 mRNAs and metabolic syndrome)
    Masaya Yamaoka
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2 2 B5 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 433:450-5. 2013
    ..recently analyzed the association between visceral fat adiposity and the gene expression profile in peripheral blood cells in human subjects and demonstrated the close relationship of visceral fat adiposity and disturbance of ..
  8. pmc Cost-effective and compact wide-field fluorescent imaging on a cell-phone
    Hongying Zhu
    UCLA Electrical Engineering Department, Los Angeles, CA 90095, USA
    Lab Chip 11:315-22. 2011
    ..g., blood, urine, sputum or water, and for this end we also demonstrate fluorescent imaging of labeled white-blood cells from whole blood samples, as well as water-borne pathogenic protozoan parasites such as Giardia Lamblia cysts...
  9. pmc Menstrual blood cells display stem cell-like phenotypic markers and exert neuroprotection following transplantation in experimental stroke
    Cesar V Borlongan
    Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Stem Cells Dev 19:439-52. 2010
    ..The present neurostructural and behavioral benefits afforded by transplanted menstrual blood-derived cells support their use as a stem cell source for cell therapy in stroke...
  10. pmc Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome
    Judy A Mikovits
    Whittemore Peterson Institute, Reno, Nevada, USA
    Virulence 1:386-90. 2010
    ..We advocate the use of more than one type of assay in order to determine the frequency of XMRV infection in patient cohorts in future studies of the relevance of XMRV to human disease...
  11. ncbi Blood cells of Drosophila: cell lineages and role in host defence
    Marie Meister
    Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, 67084 Strasbourg, France
    Curr Opin Immunol 16:10-5. 2004
    ..Crystal cells and lamellocytes have no clear mammalian homologues. Research into the molecular mechanisms that underlie the various immune functions of Drosophila blood cells, such as non-self recognition, is now taking wing.
  12. pmc Altered immune phenotype in peripheral blood cells of patients with scleroderma-associated pulmonary hypertension
    Michael G Risbano
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Aurora, USA
    Clin Transl Sci 3:210-8. 2010
    ..Differences exist in the expression of inflammatory and immune-related genes in peripheral blood cells from patients with scleroderma-related pulmonary hypertension compared to those with normal pulmonary artery ..
  13. ncbi In vivo formation of gamma-H2AX and 53BP1 DNA repair foci in blood cells after radioiodine therapy of differentiated thyroid cancer
    Michael Lassmann
    Department of Nuclear Medicine, University of Wurzburg, Wurzburg, Germany
    J Nucl Med 51:1318-25. 2010
    ....
  14. ncbi Biology of peripheral blood cells in obstructive sleep apnea--the tip of the iceberg
    Lena Lavie
    Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Arch Physiol Biochem 114:244-54. 2008
    ..These facilitate increased interactions of blood cells with endothelial cells, resulting in endothelial cell injury and dysfunction...
  15. ncbi Low-dose radiation (LDR) induces hematopoietic hormesis: LDR-induced mobilization of hematopoietic progenitor cells into peripheral blood circulation
    Wei Li
    Department of Hematology and Oncology, First University Hospital, PR China
    Exp Hematol 32:1088-96. 2004
    ..The aim of this study was to investigate the stimulating effect of low-dose radiation (LDR) on bone marrow hematopoietic progenitor cell (HPC) proliferation and peripheral blood mobilization...
  16. pmc Expression and activation by Epstein Barr virus of human endogenous retroviruses-W in blood cells and astrocytes: inference for multiple sclerosis
    Giuseppe Mameli
    Department of Biomedical Sciences and Centre of Excellence for Biotechnology Development and Biodiversity Research, University of Sassari, Sassari, Italy
    PLoS ONE 7:e44991. 2012
    ....
  17. ncbi Origin of blood cells and HSC production in the embryo
    Guilherme Costa
    Cancer Research UK Stem Cell Hematopoiesis Group, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
    Trends Immunol 33:215-23. 2012
    ..A better understanding of HSC development during ontogeny is essential to develop new strategies to amplify HSCs or to generate them from embryonic stem cells or by somatic cell reprogramming...
  18. pmc Geldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat-shock protein 90 kDa after exposure to ionizing radiation
    Risaku Fukumoto
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Radiat Res 176:333-45. 2011
    ..Hsp90 inhibitors such as 17-DMAG may prove useful with radiation-based cancer therapy as well as for general radioprotection...
  19. ncbi Yolk-sac hematopoiesis: the first blood cells of mouse and man
    J Palis
    University of Rochester, Department of Pediatrics and Cancer Center, Rochester, NY 14642, USA
    Exp Hematol 29:927-36. 2001
    ..To review the process of blood-cell formation in the murine and human yolk sac...
  20. ncbi Transcriptional profiling of peripheral blood cells in clinical pharmacogenomic studies
    Michael E Burczynski
    Wyeth Research, Pharmacogenomic Biomarkers, Biomarker Laboratory, 500 Arcola Road, Collegeville, PA 19426, USA
    Pharmacogenomics 7:187-202. 2006
    ..The hypothesis is that the circulating blood cells monitor the physiological state of the organism and alter their transcriptome in response to this surveillance...
  21. ncbi Differential localization of myosin-II isozymes in human cultured cells and blood cells
    P Maupin
    Department of Cell Biology and Anatomy, Johns Hopkins Medical School, Baltimore, MD 21205 2196
    J Cell Sci 107:3077-90. 1994
    ..directly labeled with fluorescent dyes to localize these myosin-II isozymes in HeLa cells, melanoma cells and blood cells. Both antibodies react strongly with myosin-II isozymes in HeLa cells, melanoma cells and blood eosinophils, ..
  22. ncbi Increased acid sphingomyelinase activity in peripheral blood cells of acutely intoxicated patients with alcohol dependence
    Martin Reichel
    Department of Psychiatry and Psychotherapy, University of Erlangen, Erlangen, Germany
    Alcohol Clin Exp Res 34:46-50. 2010
    ..Ethanol-induced activation of ASM has been observed in different cell culture systems, thus raising the question about the effect of alcohol intoxication in human subjects on ASM activity in vivo...
  23. pmc Both primitive and definitive blood cells are derived from Flk-1+ mesoderm
    Jesse J Lugus
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 113:563-6. 2009
    ..However, this concept has not been completely proven, especially for the origin of blood cells. Using either Flk1(+/Cre);Rosa26R-EYFP or Flk1(+/Cre);Rosa26R-LacZ mice, we permanently marked Flk-1(+) cells ..
  24. pmc Diminished expression of complement regulatory proteins on peripheral blood cells from systemic lupus erythematosus patients
    Ana Paula Alegretti
    Serviço de Patologia Clínica, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, 2 andar, 90035 903 Porto Alegre, RS, Brazil
    Clin Dev Immunol 2012:725684. 2012
    ..The aim of this study was to evaluate the Creg expression on peripheral blood cells from SLE patients and its association with cytopenia and disease activity...
  25. ncbi Plasma malondialdehyde levels and CXCR4 expression in peripheral blood cells of breast cancer patients
    Juliana Laino do Val Carneiro
    Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Campus Universitario, CEP 86051 970 Londrina, PR, Brazil
    J Cancer Res Clin Oncol 135:997-1004. 2009
    ..This study examined CXCR4 mRNA expression in peripheral blood cells and malondialdehyde (MDA) in plasma from blood donors and breast cancer patients.
  26. ncbi Characterization of the expression of HTm4 (MS4A3), a cell cycle regulator, in human peripheral blood cells and normal and malignant tissues
    Jeffery L Kutok
    Harvard Medical School, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cell Mol Med 15:86-93. 2011
    ..Here we describe the expression pattern of HTm4 in peripheral blood cells using gene expression microarray technology, and in normal foetal and adult human tissues, as well as adult ..
  27. pmc Differential serotonin transport is linked to the rh5-HTTLPR in peripheral blood cells
    Y S Singh
    Department of Chemistry, Pennsylvania State University, University Park, PA, USA
    Transl Psychiatry 2:e77. 2012
    ..We studied the serotonin system as it relates to the 5-HTTLPR in rhesus peripheral blood cells. Sequencing of the rh5-HTTLPR revealed a 23-bp insertion, which is somewhat longer than originally reported...
  28. ncbi Molecular profiling of peripheral blood cells from patients with polycythemia vera and related neoplasms: identification of deregulated genes of significance for inflammation and immune surveillance
    Vibe Skov
    Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
    Leuk Res 36:1387-92. 2012
    ..Our findings may reflect chronic inflammation to be of pathogenetic importance for the progression of these neoplasms toward the myelofibrotic end-stage and may also account for the increased frequency of second cancer in these diseases...
  29. ncbi Pathway analysis in blood cells of pigs infected with classical swine fever virus: comparison of pigs that develop a chronic form of infection or recover
    Marcel Hulst
    Livestock Research of Wageningen University and Research Centre, P O Box 65, 8200 AB, Lelystad, The Netherlands
    Arch Virol 158:325-39. 2013
    ..Using whole-genome microarrays, time-dependent changes in gene expression were recorded in blood cells of chronically diseased pigs and pigs that recovered...
  30. ncbi Morphological and functional characterization of leech circulating blood cells: role in immunity and neural repair
    Céline Boidin-Wichlacz
    Laboratoire de Neuroimmunologie et Neurochimie Evolutive, CNRS, FRE3249, Universite de Lille 1, Villeneuve d Ascq, France
    Cell Mol Life Sci 69:1717-31. 2012
    ..The morphology and the function of leech blood cells are reported here...
  31. pmc Identification of inducible nitric oxide synthase in peripheral blood cells as a mediator of myocardial ischemia/reperfusion injury
    Yiru Guo
    Institute of Molecular Cardiology, University of Louisville, 550 S Jackson Street ACB Bldg, 3rd Floor, Louisville, KY 40202, USA
    Basic Res Cardiol 107:253. 2012
    ..To test this hypothesis, we created chimeric mice with iNOS-deficient peripheral blood cells by transplanting iNOS knockout (KO) bone marrow in wild-type (WT) mice after lethal irradiation...
  32. ncbi The effect of melatonin on peripheral blood cells during total body irradiation in rats
    Mehmet Koc
    Department of Radiation Oncology, Medical School of Ataturk University, Erzurum, Turkey
    Biol Pharm Bull 25:656-7. 2002
    ..radioprotective effects of pharmacological doses of melatonin in total body irradiated rat's peripheral blood cells. Forty adult rats were divided into 4 equal groups...
  33. pmc Radiation-induced micro-RNA expression changes in peripheral blood cells of radiotherapy patients
    Thomas Templin
    Center for Radiological Research, Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 80:549-57. 2011
    ..Our in vivo study measured miRNA and gene expression changes in human blood cells in response to ionizing radiation, to develop miRNA signatures that can be used as biomarkers for radiation ..
  34. ncbi Mass spectrometric analysis of lipid species of human circulating blood cells
    Katharina Leidl
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Biochim Biophys Acta 1781:655-64. 2008
    ..Here we compared lipid species in monocytes, lymphocytes, granulocytes, platelets and red blood cells (RBC) of healthy volunteers using electrospray ionization tandem mass spectrometry and detected striking ..
  35. ncbi Transcriptional regulation of eater gene expression in Drosophila blood cells
    Paul T Kroeger
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Genesis 50:41-9. 2012
    ..This suggests that Serpent regulates eater expression by binding these GATA sites, which was confirmed by gel shift analysis. These analyses allowed us to use eater-Gal4 to force plasmatocyte to lamellocyte differentiation...
  36. ncbi The oxidative status of blood cells in a murine model of graft-versus-host disease
    Johnny Amer
    Department of Hematology, Hadassah University Hospital, Ein Kerem, POB 12000, Jerusalem, 91120, Israel
    Ann Hematol 86:753-8. 2007
    We studied the oxidative status of red and white blood cells during the development of graft vs host disease (GVHD) as well as the effects of treatment with antioxidants, both in vitro and in vivo...
  37. ncbi The utility of gene expression in blood cells for diagnosing neuropsychiatric disorders
    Christopher H Woelk
    Department of Medicine, University of California San Diego, La Jolla, California, USA
    Int Rev Neurobiol 101:41-63. 2011
    Objective diagnostic tools are required for neuropsychiatric disorders. Gene expression in blood cells may provide such a tool and has already been used to construct classifiers capable of diagnosing many human diseases...
  38. ncbi Gene profiling identifies secreted protein transcripts from peripheral blood cells in coronary artery disease
    Jun Ma
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ont, Canada M5G 1L5
    J Mol Cell Cardiol 35:993-8. 2003
  39. ncbi Profiling of length heteroplasmies in the human mitochondrial DNA control regions from blood cells in the Korean population
    Myung Geun Shin
    Department of Laboratory Medicine, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Hwasun, South Korea
    Electrophoresis 27:1331-40. 2006
    The length heteroplasmies in the hypervariable (HV) regions of mitochondrial DNA (mtDNA) from blood cells were examined in 57 healthy Korean donors...
  40. ncbi Microfluidic structures for flow cytometric analysis of hydrodynamically focussed blood cells fabricated by ultraprecision micromachining
    A Kummrow
    Physikalisch Technische Bundesanstalt, Abbestr 2 12, 10587, Berlin, Germany
    Lab Chip 9:972-81. 2009
    ..microfluidic structures with integrated optical fibers, mirrors and electrodes for flow cytometric analysis of blood cells. Ultraprecision milling technique was used to fabricate different flow cells featuring single-stage and two-..
  41. ncbi Integrated protein network and microarray analysis to identify potential biomarkers after myocardial infarction
    Yvan Devaux
    Laboratory of Cardiovascular Research, Centre de Recherche Public Santé, 120 route d Arlon, 1150, Luxembourg, Luxembourg
    Funct Integr Genomics 10:329-37. 2010
    ..in MI patients, we designed an approach combining protein interaction networks and microarray analysis of blood cells. Blood samples for RNA and protein analysis were taken from 127 acute MI patients...
  42. ncbi Supplementation with a fish oil-enriched, high-protein medical food leads to rapid incorporation of EPA into white blood cells and modulates immune responses within one week in healthy men and women
    Joyce Faber
    Nutricia Advanced Medical Nutrition, Danone Research Center for Specialized Nutrition, Wageningen 6704PH, The Netherlands
    J Nutr 141:964-70. 2011
    ..regarding short-term incorporation, the present study investigated the incorporation of EPA and DHA into white blood cells (WBC) at different time points during 1 wk of supplementation with a medical food, which is high in protein and ..
  43. ncbi Immunomodulatory effect of vitamin C on intracytoplasmic cytokine production in neonatal cord blood cells
    Christoph Hartel
    Department of Pediatrics, University of Lubeck Medical School, Lubeck, Germany
    Neonatology 91:54-60. 2007
    ..cytokines such as interleukin (IL)-6 and tumor necrosis factor alpha (TNF-alpha) in adult whole blood cells in vitro...
  44. ncbi Effect of Er:YAG and Diode lasers on the adhesion of blood components and on the morphology of irradiated root surfaces
    Leticia Helena Theodoro
    Department of Periodontology, Araraquara Dental School, State University of Sao Paulo, Araraquara, Sao Paulo, Brazil
    J Periodontal Res 41:381-90. 2006
    ..94 microm) and GaAlAs Diode (808 nm) lasers and the effects on the morphology of irradiated root surfaces...
  45. ncbi Gene expression signatures in peripheral blood cells from Japanese women exposed to environmental cadmium
    Satoru Dakeshita
    Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushima 770 8503, Japan
    Toxicology 257:25-32. 2009
    ..was to examine the effects of environmental cadmium (Cd) exposure on the gene expression profile of peripheral blood cells, using an original oligoDNA microarray...
  46. ncbi Diprotin A infusion into nonobese diabetic/severe combined immunodeficiency mice markedly enhances engraftment of human mobilized CD34+ peripheral blood cells
    Toshinao Kawai
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1456, USA
    Stem Cells Dev 16:361-70. 2007
    ..at the time of transplant of human granulocyte colony-stimulating factor (G-CSF) mobilized CD34(+) peripheral blood cells (CD34(+) PBCs) results in a >3.4-fold enhancement of engraftment of human cells...
  47. ncbi Tissue factor/TFPI and blood cells
    Bjarne Osterud
    HERG, Department of Medical Biology, Faculty of Health Sciences and MabCent SFI, University of Tromsø, 9037 Tromsø, Norway
    Thromb Res 129:274-8. 2012
    ..in extravascular sites exclusively has recently been challenged by several reports on TF expression in various blood cells. The latter arena has unfortunately been marred by many contradictions, apparently related to inferior tools ..
  48. ncbi Methylation-related mutations in the BRCA1 promoter in peripheral blood cells from cancer-free women
    Nisreen Al-Moghrabi
    DNA Repair and Apoptosis Section, Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, MBC 03, PO Box 3354, Riyadh 11211, Saudi Arabia
    Int J Oncol 39:129-35. 2011
    ..the epigenetic modifications of the breast cancer type 1 susceptibility gene (BRCA1) in breast tissues and blood cells derived from women with breast cancer and women without breast cancer...
  49. ncbi Direct sensing of systemic and nutritional signals by haematopoietic progenitors in Drosophila
    Jiwon Shim
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California 90095, USA
    Nat Cell Biol 14:394-400. 2012
    ..of the primary lobe of the lymph gland called the medullary zone contains these progenitors, and maturing blood cells are found juxtaposed in a peripheral region designated the cortical zone...
  50. ncbi Gene expression profile of Ci-VSP in juveniles and adult blood cells of ascidian
    Michio Ogasawara
    Department of Nanobiology, Graduate School of Advanced Integration Science, Chiba University, Yayoi cho 1 33, Inage Ku, Chiba 263 8522, Japan
    Gene Expr Patterns 11:233-8. 2011
    ..Whole mount in situ hybridization showed that Ci-VSP is expressed in cells of the stomach, intestine and blood cells of 2- to 3-week-old juveniles...
  51. ncbi Receptor mediated binding of the fibrinolytic components, plasminogen and urokinase, to peripheral blood cells
    L A Miles
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037
    Thromb Haemost 58:936-42. 1987
    ..This study assesses the interaction of these fibrinolytic proteins with circulating human blood cells. Plasminogen bound minimally to red cells but bound saturably and reversibly to monocytes, granulocytes and ..
  52. ncbi Determinants of atherosclerosis susceptibility in the C3H and C57BL/6 mouse model: evidence for involvement of endothelial cells but not blood cells or cholesterol metabolism
    W Shi
    Department of Medicine, University of California, Los Angeles, CA 90095 1679, USA
    Circ Res 86:1078-84. 2000
    ..These data provide strong evidence that endothelial cells, but not monocytes or plasma lipid levels, account for the difference in susceptibility to atherosclerosis between the 2 mouse strains...
  53. ncbi Telomere length in fibroblasts and blood cells from healthy centenarians
    C Mondello
    Istituto di Genetica Biochimica ed Evoluzionistica of CNR, via Abbiategrasso 207, Pavia, 27100, Italy
    Exp Cell Res 248:234-42. 1999
    ..In blood cells from various individuals, the expected inverse correlation between mean TRF length and donor age was found...
  54. ncbi N-acetylcysteine amide (AD4) attenuates oxidative stress in beta-thalassemia blood cells
    Johnny Amer
    Department of Hematology, Hadassah Hebrew University Medical Center, Jerusalem
    Biochim Biophys Acta 1780:249-55. 2008
    ..Using flow-cytometry, we showed that in vitro treatment of blood cells from beta-thalassemic patients with AD4 elevated the reduced glutathione (GSH) content of red blood cells (RBC),..
  55. pmc Relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population
    Eleonora Dehlink
    Division of Gastroenterology and Nutrition and EGID Centre, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e12204. 2010
    ..The aim of this study was to analyze the relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population.
  56. ncbi A germline GFP transgenic axolotl and its use to track cell fate: dual origin of the fin mesenchyme during development and the fate of blood cells during regeneration
    Lidia Sobkow
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Dev Biol 290:386-97. 2006
    ..During tail regeneration, we do not observe GFP+ cells contributing to muscle or nerve, suggesting that during tail regeneration blood stem cells do not undergo significant plasticity...
  57. ncbi Gene expression signature in peripheral blood cells from medical students exposed to chronic psychological stress
    Tomoko Kawai
    Department of Stress Science, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima, Japan
    Biol Psychol 76:147-55. 2007
    ..Of the 24 genes, real-time PCR validated changes in mRNA levels of 10 (PLCB2, CSF3R, ARHGEF1, DPYD, CTNNB1, PPP3CA, POLM, IRF3, TP53, and CCNI). The identified genes may be useful to assess chronic psychological stress response...
  58. ncbi Structural and functional characterisation of the blood cells of the bivalve mollusc, Scrobicularia plana
    E C Wootton
    Marine Biological Association, Citadel Hill, PL1 2PB Plymouth, UK
    Fish Shellfish Immunol 15:249-62. 2003
    Light and electron microscopical studies were carried out in order to characterise the blood cells of the bivalve mollusc, Scrobicularia plana...
  59. ncbi Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study
    Moshe Talpaz
    M D Anderson Cancer Center, Houston, Texas, USA
    Blood 99:1928-37. 2002
    ..Orally administered imatinib is an effective and well-tolerated treatment for patients with CML in accelerated phase. A daily dose of 600 mg is more effective than 400 mg, with similar toxicity...
  60. ncbi Flow cytometric measurement of microparticles: pitfalls and protocol modifications
    Mona D Shah
    Baylor College opf Medicine, Texas Children s Cancer Center and Hematology Service, Texas Children s Hospital, Houston, Texas 77030, USA
    Platelets 19:365-72. 2008
    ..These results illustrate the need to standardize assay protocols in order to obtain consistent measurements. Our studies further optimize sample preparation for microparticle detection...
  61. ncbi Influence of root-surface conditioning with acid and chelating agents on clot stabilization
    Fabio Renato Manzolli Leite
    Department of Semilogy and Clinics, School of Dentistry, Federal University of Pelotas UFPel Pelotas, Rio Grande do Sul, Brazil
    Quintessence Int 41:341-9. 2010
    ..To compare the adhesion and maturation of blood components on chemically conditioned root surfaces...
  62. pmc Precision of pyrosequencing assay to measure LINE-1 methylation in colon cancer, normal colonic mucosa, and peripheral blood cells
    Natsumi Irahara
    Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney St, Room JF 215C, Boston, MA 02115, USA
    J Mol Diagn 12:177-83. 2010
    ..In addition, LINE-1 hypomethylation in blood cells has been associated with colorectal adenoma risk, and LINE-1 hypomethylation in colorectal cancer is related ..
  63. ncbi The inflammation-fibrosis link? A Jekyll and Hyde role for blood cells during wound repair
    Brian M Stramer
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, UK
    J Invest Dermatol 127:1009-17. 2007
    ....
  64. pmc Hematopoietic cell types: prototype for a revised cell ontology
    Alexander D Diehl
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Biomed Inform 44:75-9. 2011
    ..The methods and improvements to the CL in this area represent a paradigm for improvement of the entire ontology over time...
  65. ncbi The next generation of burns treatment: intelligent films and matrix, controlled enzymatic debridement, and adult stem cells
    H Drago
    Banco de Tejidos, Hospital de Quemados, CABA, Argentina
    Transplant Proc 42:345-9. 2010
    ....
  66. pmc Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program
    Maarten Hoogenkamp
    Leeds Institute for Molecular Medicine, University of Leeds, Leeds, United Kingdom
    Blood 114:299-309. 2009
    ..Our experiments therefore demonstrate how individual transcription factors function in a differentiation stage-specific manner to differentially affect the initiation versus maintenance of a developmental program...
  67. pmc Generation of induced pluripotent stem cells from human blood
    Yuin Han Loh
    Department of Medicine, Division of Pediatric Hematology Oncology, Children s Hospital Boston, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 113:5476-9. 2009
    ..Here, we describe the derivation of induced pluripotent stem cells from CD34+ mobilized human peripheral blood cells using retroviral transduction of OCT4/SOX2/KLF4/MYC...
  68. ncbi Comparison of different isolation techniques prior gene expression profiling of blood derived cells: impact on physiological responses, on overall expression and the role of different cell types
    S Debey
    Molecular Tumor Biology and Tumor Immunology, Center for Internal Medicine, University of Cologne, Cologne, Germany
    Pharmacogenomics J 4:193-207. 2004
    ..Gene expression patterns in peripheral blood cells greatly depend on temporal and interindividual variations...
  69. ncbi Release of anandamide from blood cells
    Michael Vogeser
    Institute of Clinical Chemistry, Hospital of the University of Munich, Munich, Germany
    Clin Chem Lab Med 44:488-91. 2006
    ..Since this might be caused by pre-analytical variables, we investigated the impact of different sample handling conditions on measured plasma anandamide concentrations...
  70. ncbi Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia
    Elisabeth Kamphuis
    Division of Immunology, Paul Ehrlich Institut, Paul Ehrlich Str 51 59, D 63225 Langen, Germany
    Blood 108:3253-61. 2006
    ..In conclusion, our data identify a new effect of direct IFN-alpha/beta stimulation of lymphocytes that profoundly affects lymphocyte redistribution...
  71. ncbi Rhythms in human bone marrow and blood cells
    Rune Smaaland
    Department of Oncology, Haukeland Hospital, University of Bergen, Norway
    Chronobiol Int 19:101-27. 2002
    ....
  72. ncbi Circulating microparticles: pathophysiology and clinical implications
    Andrea Piccin
    Irish Blood Transfusion Service, James s Street, Dublin 8, Ireland
    Blood Rev 21:157-71. 2007
    Microparticles (MP) derived from vascular endothelium or circulating blood cells circulate in the peripheral blood...
  73. ncbi Effects of age, gender, and immunosuppressive agents on in vivo toll-like receptor pathway responses
    Niamat Khan
    Department of Immunology, University of Manchester, Manchester, UK
    Hum Immunol 71:372-6. 2010
    ..Furthermore, an understanding the effects of immunosuppressive agents on TLR-pathway activity should allow more focused therapy for autoimmune disorders...
  74. ncbi Nucleotide receptors: an emerging family of regulatory molecules in blood cells
    F Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology and Medical Genetics, and Center of Biotechnology, University of Ferrara, Ferrara, Italy
    Blood 97:587-600. 2001
    ..lysosomal constituents, and generation of reactive oxygen or nitrogen species are elicited upon stimulation of blood cells with extracellular adenosine triphosphate (ATP)...
  75. ncbi Telomere length in haemopoietic stem cells can be determined from that of mononuclear blood cells or whole blood
    Jennette A Sakoff
    Department of Medical Oncology, Newcastle Mater Misericordiae Hospital, Newcastle, Locked Bag No 7, Hunter Region Mail Center, 2310, NSW, Australia
    Leuk Lymphoma 43:2017-20. 2002
    ..83, P < 0.001). Thus, telomere length in haemopoietic stem cells can be determined from that of whole or fractionated PB in future studies of haematological disorders...
  76. ncbi Expression of adenosine triphosphate-binding cassette (ABC) drug transporters in peripheral blood cells: relevance for physiology and pharmacotherapy
    Kathleen Köck
    Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, Ernst Moritz Arndt University, Greifswald, Germany
    Clin Pharmacokinet 46:449-70. 2007
    ..g. in the brain or the gastrointestinal tract). In this context, peripheral blood cells have also been found to express several ABC-type transporters...
  77. ncbi Role of polyamines derived from arginine in differentiation and proliferation of human blood cells
    Tomoji Maeda
    Department of Molecular Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamasaki, Noda, Chiba 278 8510, Japan
    Biol Pharm Bull 29:234-9. 2006
    ..nitric oxide (NO), creatine, and agmatine and is essential for the differentiation and proliferation of blood cells, although the precise biological role of L-arginine is unclear...
  78. ncbi The serine protease Sp7 is expressed in blood cells and regulates the melanization reaction in Drosophila
    Casimiro Castillejo-Lopez
    Department of Experimental Medical Science and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, BMC B13, Klinikgatan 26, 22184 Lund, Sweden
    Biochem Biophys Res Commun 338:1075-82. 2005
    ..We show that Sp7 is constitutively expressed in blood cells during embryonic and larval stages. Silencing of the gene impairs the melanization reaction upon injury...
  79. pmc Isolation of rare tumor cells from blood cells with buoyant immuno-microbubbles
    Guixin Shi
    Moores Cancer Center, University of California San Diego, La Jolla, California, USA
    PLoS ONE 8:e58017. 2013
    ..Here we report a novel method for isolation of rare tumor cells from excess of blood cells using gas-filled buoyant immuno-microbubbles (MBs)...
  80. ncbi Differential expression of wild-type and mutant NMMHC-IIA polypeptides in blood cells suggests cell-specific regulation mechanisms in MYH9 disorders
    Shinji Kunishima
    Department of Hemostasis and Thrombosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    Blood 111:3015-23. 2008
    ..We examined the expression of mutant NMMHC-IIA polypeptide in peripheral blood cells from patients with MYH9 5770delG and 5818delG mutations...
  81. ncbi [(3)H]Nicotine binding in peripheral blood cells of smokers is correlated with the number of cigarettes smoked per day
    K Benhammou
    Department of Psychiatry, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Neuropharmacology 39:2818-29. 2000
    ..Expression of both mRNA and protein in lymphocytes and PMN, for a subset of nicotinic receptor subunits, suggests that these cell types contain both alpha4beta2 and alpha3beta4 receptors...
  82. ncbi Xenotropic murine leukaemia virus-related virus is not found in peripheral blood cells from treatment-naive human immunodeficiency virus-positive patients
    F Maggi
    Virology Unit, Pisa University Hospital, Pisa, Italy
    Clin Microbiol Infect 18:184-8. 2012
    ..Using nested PCR and single-step TaqMan real-time PCR, both designed on the XMRV gag gene, we could not find any positive samples. These findings add to the growing amount of scepticism regarding XMRV...
  83. pmc Expression profiling of circulating non-red blood cells in embryonic blood
    Brendan A S McIntyre
    Laboratory for Early Embryogenesis, RIKEN Center for Developmental Biology, Kobe, Hyogo 650 0047, Japan
    BMC Dev Biol 8:21. 2008
    ..Using chicken as a model system, we have isolated an enriched pool of circulating non red blood cells (nRBCs) from E4 and E6 embryos; a transition period when definitive hematopoietic lineages are being specified ..
  84. ncbi Dendritic cell-associated lectin-1: a novel dendritic cell-associated, C-type lectin-like molecule enhances T cell secretion of IL-4
    Elizabeth J Ryan
    Regional Primate Research Center, Box 357330, University of Washington, Seattle, WA 98195, USA
    J Immunol 169:5638-48. 2002
    ..Therefore, the function of DCAL-1 on DCs and B cells may act as a T cell costimulatory molecule, which skews CD4(+) T cells toward a Th2 response by enhancing their secretion of IL-4...
  85. ncbi Functional eicosanoid test and typing (FET) of peripheral blood cells in eicosanoids related diseases
    D Schafer
    Medizinische Klinik III mit Poliklinik, Abteilung für Allergologie, Friedrich Alexander Universitat Erlangen Nurnberg, Krankenhausstr 29, D 91054 Erlangen, Germany
    J Physiol Pharmacol 56:103-18. 2005
    Monitoring of eicosanoid synthesis in peripheral blood cells has significant potential for improving the diagnosis and therapy of many human diseases...
  86. pmc Toward personalized cell therapies: autologous menstrual blood cells for stroke
    Maria Carolina O Rodrigues
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, Tampa, FL 33612, USA
    J Biomed Biotechnol 2011:194720. 2011
    ..We here propose the use of autologous menstrual blood cells in the restorative treatment of the subacute phase of stroke...
  87. pmc Hemodynamic measurements from individual blood cells in early mammalian embryos with Doppler swept source OCT
    Irina V Larina
    Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77584, USA
    Opt Lett 34:986-8. 2009
    ..5 day embryo just a few hours after the beginning of a heartbeat. Our data show that individual circulating blood cells can be visualized with structural SS-OCT, and using Doppler SS-OCT the velocity of single moving blood cells ..
  88. ncbi Oxidative DNA damage in peripheral blood cells in type 2 diabetes mellitus: higher vulnerability of polymorphonuclear leukocytes
    Vanessa Pitozzi
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Mutat Res 529:129-33. 2003
    ..and DNA base oxidation, measured as FPG (formamidopyrimidine DNA glycosylase)-sensitive sites, in peripheral blood cells (PBC) from type 2 diabetes patients and healthy controls...
  89. pmc Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells
    Elizabeth A DiBlasio-Smith
    Department of Biological Technologies, Wyeth Research, 35 CambridgePark Drive, Cambridge, MA 02140, USA
    J Transl Med 6:59. 2008
    ..Anti-atherosclerotic effects of synthetic LXR agonists in murine models suggest clinical utility for such compounds...
  90. pmc Effects of acetaminophen on constitutive and inducible prostanoid biosynthesis in human blood cells
    Maria G Sciulli
    Centre of Excellence on Aging, G D Annunzio University, School of Medicine, Chieti, Italy
    Br J Pharmacol 138:634-41. 2003
    ....
  91. ncbi Drug treatment of Alzheimer's disease patients leads to expression changes in peripheral blood cells
    Margaret A Calciano
    ExonHit Therapeutics Inc, Gaithersburg, MD, USA
    Alzheimers Dement 6:386-93. 2010
    ..The goal of this study was to determine the feasibility of discovering biomarkers specific for the treatment of Alzheimer's disease...
  92. ncbi [Sharp changes in the copy number of mtDNA and its transcription in the blood cells of X-ray irradiated mice are observed, and mtDNA fragments appear in the blood serum]
    E V Evdokimovskiĭ
    Radiats Biol Radioecol 47:402-7. 2007
    ..in the number of mitochondrial DNA (mtDNA) copies and alterations in its transcription were followed in the blood cells of mice after their exposure to X-rays; also, extracellular mtDNA fragments were registered in the blood serum ..
  93. pmc Comparison of the DNA methylation profiles of human peripheral blood cells and transformed B-lymphocytes
    Yan V Sun
    Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights 4629, Ann Arbor, MI 48109, USA
    Hum Genet 127:651-8. 2010
    ..One was extracted from peripheral blood cells (PBC) and the other from transformed B-lymphocytes (TBL)...
  94. ncbi The effect of VEGF on blood vessels and blood cells during Xenopus development
    Nobutaka Koibuchi
    Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita 565 0871, Japan
    Biochem Biophys Res Commun 344:339-45. 2006
    ..of vasculogenesis in the posterior portion of the blood island, with excessive production of endothelial cells at the expense of blood cells, and that the anterior and posterior portions of the VBI may have distinct characteristics.
  95. pmc Profile of blood cells and inflammatory mediators in periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome
    Kelly L Brown
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    BMC Pediatr 10:65. 2010
    This study aimed to profile levels of blood cells and serum cytokines during afebrile and febrile phases of periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome to advance pathophysiological understanding of ..
  96. ncbi Inhibition of chemiluminescence by carvedilol in the cell-free system, whole human blood and blood cells
    R Nosal
    Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Scand J Clin Lab Invest 65:55-64. 2005
    ..This could be the result of the supportive effect of serotonin liberated from platelets by A23187...
  97. ncbi Differential interaction of magnetic nanoparticles with tumor cells and peripheral blood cells
    J H Clement
    Department of Internal Medicine II, Friedrich Schiller University Jena, Erlanger Allee 101, 07740, Jena, Germany
    J Cancer Res Clin Oncol 132:287-92. 2006
    ..The separation of tumor cells from healthy cells is a vital problem in oncology and hematology, especially from peripheral blood. Magnetic assisted cell sorting (MACS) is a possibility to fulfill these needs...
  98. ncbi Detection of the 4977 bp deletion of mitochondrial DNA in different human blood cells
    S A Mohamed
    Department of Legal Medicine, Medical University of Luebeck, Kahlhorststrasse 31 35, Luebeck 23562, Germany
    Exp Gerontol 39:181-8. 2004
    ..Differences of the accumulation pattern may be due to actual individual living behaviour or environmental factors...
  99. ncbi Morphologic and cytochemical characteristics of blood cells of juvenile loggerhead sea turtles (Caretta caretta)
    A B Casal
    Department of Morphology, Unit of Histology and Pathology, Veterinary Faculty, University of Las Palmas de Gran Canaria ULPGC, Trasmontana s n, 35416 Arucas, Las Palmas, Spain
    Res Vet Sci 82:158-65. 2007
    A morphologic classification based on the cytochemical characteristics of blood cells of 35 juvenile loggerhead sea turtles (Caretta caretta) is described...
  100. ncbi In vivo effects of myeloablative alkylator therapy on survival and differentiation of MGMTP140K-transduced human G-CSF-mobilized peripheral blood cells
    Shanbao Cai
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, The Riley Hospital for Children, 1044 West Walnut Street R4 468, Indianapolis, IN 46202 5525, USA
    Mol Ther 13:1016-26. 2006
    ..These data suggest that improved strategies to optimize repair of DNA damage in primitive human hematopoietic cells are needed when using high-intensity anti-cancer therapy...
  101. ncbi A novel monolayer cell line derived from human umbilical cord blood cells shows high sensitivity to measles virus
    Fumio Kobune
    Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    J Gen Virol 88:1565-7. 2007
    ..Thus, COBL-a cells should prove very valuable for both epidemiological and basic studies of MeV...

Research Grants68

  1. Genetic Analysis of Intracellular Signaling Crosstalk
    WILLIS LI; Fiscal Year: 2006
    ..Results from this work should shed light on the mechanisms of signaling crosstalk that may be important for human pathogenesis as well as tumorigenesis. ..
  2. FASEB Conf. Proteases in Hemostasis and Vascular Biology
    Lawrence Brass; Fiscal Year: 2005
    ..Tissue factor, platelets and coagulation; 8. Regulators of hemostasis; 9. Protease receptors. The keynote lecture will be on gene therapy for disorders of hemostasis delivered by Dr. Katherine High. ..
  3. DEFINING HEMATOPOIETIC PROGENITORS IN MOUSE BONE MARROW
    Gerald J Spangrude; Fiscal Year: 2010
    ..In certain disease states, or following treatment for cancer, the immune system is weakened. This work seeks to define transplantation interventions that will reduce the complications associated with immune deficiencies. ..
  4. Proteomic studies of normal and abnormal platelet function
    Lawrence Brass; Fiscal Year: 2007
    ..This includes novel methods that permit quantitation of individual molecules so that changes in levels of expression can be measured. [unreadable] [unreadable] [unreadable]..
  5. Blood Systems Biology
    Lawrence Brass; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. CHARACTERIZATION OF A NOVEL G PROTEIN IN PLATELETS
    Lawrence Brass; Fiscal Year: 2005
    ..All four of these aims will combine biochemical and pharmacologic approaches with studies on genetically engineered mice lacking selected receptors and G proteins, allowing us to better understand platelet activation in vivo. ..
  7. Hematopoietic Stem/Progenitors and Local Inflammation
    Gerald Spangrude; Fiscal Year: 2004
    ..The results of this study may suggest approaches to limit pathological inflammation that sometimes impacts bone marrow transplant recipients. ..
  8. Lysate Arrays for Studying the Diabetes Proteome
    PAUL UTZ; Fiscal Year: 2006
    ..the transcriptome and proteome of pancreatic lymph node (PLN) cells, islet beta cells, and peripheral blood cells over time...
  9. Carbohydrate-carbohydrate interaction in basic cell biology
    Sen itiroh Hakomori; Fiscal Year: 2006
    ..abstract_text> ..
  10. Molecular Mechanisms of Ectopic Bone Formation
    STEVEN LIETMAN; Fiscal Year: 2006
    ..abstract_text> ..
  11. Integrated Photothermal Nanoprobes
    Vladimir Zharov; Fiscal Year: 2007
    ..The results of these studies will also make it possible to formulate recommendations on the desired properties of new, clustered nanomaterials for medical applications. [unreadable] [unreadable] [unreadable]..
  12. MGMT-Mediated in vivo Selection in a Large Animal Model
    Hans Peter Kiem; Fiscal Year: 2006
    ..These experiments will provide a platform for studies using gene-modified allogeneic stem cells to improve nonmyeloablative transplant strategies. ..
  13. Signaling by IgG receptors leading to phagocytosis
    KENNETH COGGESHALL; Fiscal Year: 2006
    ..The results will provide a better understanding of molecular process involved in clearance of infectious agents in humans. ..
  14. Multiplex Autoantibody Profiling in SLE
    PAUL UTZ; Fiscal Year: 2007
    ..Moreover, further development of protein microarray technology will have broad applications to the fields of immunology, functional genomics, and proteomics. ..
  15. Development of SL-101, An Immunotoxin that Targets Cancer Stem Cells
    Malcolm Moore; Fiscal Year: 2006
    ..This Phase I STTR grant will cover the development of SL-101 through key phases of pre-clinical development. [unreadable] [unreadable] [unreadable]..
  16. Real-time Minimal Residual Disease assay of Pediatric B-Cell Non-Hodgkin Lymphoma
    Bruce Shiramizu; Fiscal Year: 2007
    ..The assay developed by this exploratory proposal could be incorporated into pediatric B-cell NHL studies to assess MRD on therapy or to assess the efficacy of innovative therapies. [unreadable] [unreadable] [unreadable]..
  17. SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESION
    Paul J Mills; Fiscal Year: 2010
    ..abstract_text> ..
  18. BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUND
    Douglas Miller; Fiscal Year: 2009
    ..This project will examine bioeffects in cells and tissues and show how to safely use ultrasound contrast agents in diagnostic imaging. ..
  19. Resolution of Gouty Inflammation
    STEPHEN MALAWISTA; Fiscal Year: 2008
    ..We suggest further that this reprogramming of lipid mediators may explain in part the action of therapeutic agents such as colchicine, and could lead to better treatment for this condition. [unreadable] [unreadable] [unreadable]..
  20. Factor lXa-Factor Vllla complexes in blood coagulation
    Bruce Furie; Fiscal Year: 2008
    ..abstract_text> ..
  21. DROSOPHILA SENSORY NEURON DEVELOPMENT
    Volker Hartenstein; Fiscal Year: 2007
    ..abstract_text> ..
  22. Translational Immunology Core's FACSAria Cell Sorter
    Frederic Preffer; Fiscal Year: 2008
    ..Advances in medicine based on similar past work today permit curative kidney and bone marrow transplantations as well as treatments for certain autoimmune and infectious disease. ..
  23. SELECTIN LIGANDS IN LEUKOCYTE BIOLOGY AND INFLAMMATION
    Bruce Furie; Fiscal Year: 2008
    ..Finally, we propose to use the PSGL-1 null mouse to establish whether the absence of PSGL-1 will block or mitigate graft versus host disease following bone marrow transplantation in a mouse model. ..
  24. Ultrafine Particle-Induced Oxidative Stress
    Mark Frampton; Fiscal Year: 2007
    ..abstract_text> ..
  25. Sphingolipid signaling induced by LDL immune complexes
    Samar M Hammad; Fiscal Year: 2010
    ..abstract_text> ..
  26. IMMUNOLOGICAL CONSEQUENCES OF TRANSFUSION
    Loren Fast; Fiscal Year: 2002
    ..abstract_text> ..
  27. Photothermal Evaluation of Drug Toxicity at Cell Level
    Vladimir Zharov; Fiscal Year: 2004
    ..abstract_text> ..
  28. ULTRASOUND ENHANCEMENT OF CANCER GENE THERAPY
    Douglas Miller; Fiscal Year: 2003
    ..This research will provide a bridge from the basic research breakthrough to specific therapeutic applications and urgently needed clinical research programs utilizing this novel technology. ..
  29. CELL MEDIATED HEMOSTASIS
    Harold Roberts; Fiscal Year: 2004
    ....
  30. GENETIC ENGINEERING OF CELLS FROM ANEMIC ANIMALS
    Jane Barker; Fiscal Year: 2003
    ..abstract_text> ..
  31. Role of selectins and selectin ligands in the pathobiol*
    Bruce Furie; Fiscal Year: 2004
    ..To prove the physiologic importance of this pathway, we will attempt to rescue homozygous protein C deficient mice from fatal thrombosis by PSGL-1 deficiency. ..
  32. SPHINGOSINE DEPENDENT KINASE AND CARCINOGENESIS
    Senitiroh Hakomori; Fiscal Year: 2003
    ..In the inhibitory effect is confirmed, its mechanism will be studied in relation to activities of SDKs, MAPK, bcl-2, and other signal transducers. ..
  33. LENTIVIRAL VECTOR TRANSFER TO HEMATOPOIETIC STEM CELLS
    Donald Kohn; Fiscal Year: 2005
    ..This "intracellular immunization" approach may provide a therapeutic measure against HIV-1 that adds to pre-existing therapies, such as anti-retroviral drugs. ..
  34. Predictors of Skin Cancer in Commercial Airline Pilots
    Joyce Nicholas; Fiscal Year: 2005
    ..abstract_text> ..
  35. Genetic Control of Intestinal Stem Cells in the Drosophila Hindgut
    Volker Hartenstein; Fiscal Year: 2010
    ..abstract_text> ..
  36. UCSD Hillcrest Flow Cytometer
    Paul Mills; Fiscal Year: 2003
    ..It will also be the centerpiece for an environment of shared ideas and collaboration among investigators who now utilize cytometry for their research. ..
  37. LYME DISEASE--HOST PARASITE INTERACTIONS
    STEPHEN MALAWISTA; Fiscal Year: 2003
    ..These studies may provide the technical and conceptual basis for improvements in diagnostic and prognostic aspects of inflammatory diseases. ..
  38. Treg Migration in GVHD
    Jonathan Serody; Fiscal Year: 2009
    ..The overall goals of this work are to provide a better understanding of the mechanism of activity of Treg cells prior to a clinical trial evaluating their effects in blocking GVHD. ..
  39. Minimization of an anti-angiogenic protein
    Fernando Donate; Fiscal Year: 2002
    ..The need for more effective cancer therapy is readily apparent, as more than 15 million in the U.S. alone contract some type of cancer each year. This represents a potential market of $10 billion per year. ..
  40. REGULATION OF SECRETION FROM HUMAN BASOPHILS
    Donald MacGlashan; Fiscal Year: 2009
    ..A population of subjects will be examined for this relationship. ..
  41. Glycosynapses in cancer cell adhesion and signaling
    Sen itiroh Hakomori; Fiscal Year: 2009
    ....
  42. RHEOLOGICAL DETERMINANTS OF MICROVASCULAR FUNCTION
    HERBERT LIPOWSKY; Fiscal Year: 2009
    ..The results of these studies will provide insight into the role of hemodynamic interactions with the microvessel wall and aid development of therapeutic strategies to treat ischemia and inflammation. ..
  43. Development of DNA Methyltransferase Inhibitors as Anti*
    Judy Mikovits; Fiscal Year: 2003
    ..We expect to develop small molecule inhibitors with acceptable efficacy and toxicity profiles for testing in animal models of human cancers. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  44. PHOSPHORYLATION OF LUPUS AUTOANTIGENS IN APOPTOSIS
    PAUL UTZ; Fiscal Year: 2002
    ....
  45. FACTORS INFLUENCING STEM CELL AND PLATELET PRODUCTION
    Malcolm Moore; Fiscal Year: 2002
    ..e., adult populations acquiring features of neonatal cells, or whether there is a tendency for "immortalized" cells to undergo neoplastic transformation. ..
  46. Ontogeny of erythroid lineage differentiation
    James Palis; Fiscal Year: 2010
    ..first aim of this proposal, we will delineate a gene anatomy profile of primary primitive and definitive red blood cells at progressive stages of maturation...
  47. GENE THERAPY FOR HURLERS DISEASE
    Donald Kohn; Fiscal Year: 2001
    ..Successful tolerance induction in murine and canine models of MPS I will be an Important step toward application of gene therapy in human patients. ..
  48. GENETIC MODEL FOR THE ROLE OF NEUROGENESIS IN ANTIDEPRESSANT RESPONSE
    ROBERT BEECH; Fiscal Year: 2007
    ..This, in turn, should allow for a more rational search for new medications for the treatment of depression, and potentially other mental illnesses as well. [unreadable] [unreadable] [unreadable]..
  49. Whole Autologous SIV Vaccine Using Dendritic Cells
    SIMON BARRATT BOYES; Fiscal Year: 2006
    ....
  50. Multimodality Therapy for Metastatic Breast Cancer
    Jonathan Serody; Fiscal Year: 2006
    ..The long-term goals of this work are to evaluate safe and effective therapies that induce a complete remission for the treatment of women with metastatic breast cancer. ..
  51. Nuclear and genomic organization of gene expression
    Jeanne Lawrence; Fiscal Year: 2006
    ..Hypotheses tested have potential to elucidate the functional evolution of the karyotype and such features as cytogenetic bands and conserved gene clusters, which may associate with distinct intranuclear compartments. ..
  52. The heat shock response and cytoprotection
    Hector Wong; Fiscal Year: 2006
    ....
  53. Department of Pathology LSR2 Cytometer
    Frederic Preffer; Fiscal Year: 2005
    ..The laboratory has the documented financial support of both the Department of Pathology and MGH administration. ..
  54. INTRAVITAL VIDEO-RATE CONFOCAL MICROSCOPE
    Bruce Furie; Fiscal Year: 2001
    ..The BioRad RTS2000 real-time laser confocal system, fitted to a Nikon E600FN microscope, will provide a group of investigators with instrumentation to significantly advance their fields. ..
  55. Initiation of Mammalian Yolk Sac Hematopoiesis
    James Palis; Fiscal Year: 2006
    ..This will ultimately lead to improvements in bone marrow transplantation for the curative treatment of congenital anemias, genetic diseases and several forms of childhood and adult cancers. ..
  56. Embryonic hematopoietic stem cell origin and ontogeny
    James Palis; Fiscal Year: 2004
    ..During development, primitive eiythroblasts arise in the yolk sac while definitive blood cells subsequently differentiate in the fetal liver and bone marrow...
  57. Ultrafine Particle Exposure in Humans
    Mark Frampton; Fiscal Year: 2005
    ..These studies will identify key mechanisms for the cardiovascular effects of exposure to ambient air particles. ..
  58. Assessing Circulating Progenitor Cells in Heart Disease
    Thomas Povsic; Fiscal Year: 2007
    ..This study will look at two methods of measuring these stem cells in the blood of heart patients. These methods may someday be used to predict who will or will not develop heart disease or other complications. ..
  59. Genomic analysis of pediatric SIRS and septic shock
    Hector Wong; Fiscal Year: 2009
    ..Child health will be positively impacted by developing the capability of conducting zinc supplementation trials in a safe and rigorous manner. ..
  60. Network Interaction between EGFR and TGFbeta Pathways
    WILLIS LI; Fiscal Year: 2009
    ..abstract_text> ..
  61. A targeted peptide for PET imaging of cancer
    Fernando Donate; Fiscal Year: 2004
    ..abstract_text> ..
  62. Activation & Proliferation of Hematopoietic Stem Cells
    Peter Lansdorp; Fiscal Year: 2006
    ..These techniques will also be used to further study the age related decline in telomere length in nucleated blood cells from normal individuals, patients with various hematological disorders and pedigrees of genotyped normal ..
  63. CNS Viral Dynamics and Cellular Immunity During AIDS
    David Haas; Fiscal Year: 2009
    ..Characterizing these relationships will expand our knowledge regarding key events that lead to AIDS dementia, and may suggest novel approaches to other immunologic or viral-mediated diseases that affect the brain. ..
  64. PROGESTOGENS VS PHYTOESTROGENS-- AN ADJUNCT TO ERT
    James Williams; Fiscal Year: 2004
    ....
  65. VANDERBILT ADULT AIDS CLINICAL TRIALS UNIT
    David Haas; Fiscal Year: 2006
    ..The proposed ACTU will not only enroll patients into ACTG clinical trials, but will provide the ACTG the ability to address important questions concerning AIDS treatment and pathogenesis. ..
  66. Zinc, Mental Health and School Performance in Mexico
    ARYEH STEIN; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  67. Evaluation of Stimulant Drugs
    Sharon Wigal; Fiscal Year: 2006
    ..Within-subject PK variability in time-course of serum concentration for each medication will be analyzed, and the time-response characteristics also will be estimated based on PD measures for methylphenidate. ..