langerhans cells

Summary

Summary: Recirculating, dendritic, antigen-presenting cells containing characteristic racket-shaped granules (Birbeck granules). They are found principally in the stratum spinosum of the epidermis and are rich in Class II major histocompatibility complex molecules.

Top Publications

  1. pmc IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
    Yaming Wang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Immunol 13:753-60. 2012
  2. pmc Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages
    Guillaume Hoeffel
    Singapore Immunology Network, Agency for Science, Technology and Research A STAR, Immunos Building 3 4, Biopolis, 138648, Singapore
    J Exp Med 209:1167-81. 2012
  3. ncbi Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia
    Melanie Greter
    Institute of Experimental Immunology, Neuroimmunology, University of Zurich, Zurich, Switzerland
    Immunity 37:1050-60. 2012
  4. pmc Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells
    Julien Seneschal
    Department of Dermatology Harvard Skin Disease Research Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    Immunity 36:873-84. 2012
  5. ncbi Langerhans cells renew in the skin throughout life under steady-state conditions
    Miriam Merad
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94304, USA
    Nat Immunol 3:1135-41. 2002
  6. pmc The differential production of cytokines by human Langerhans cells and dermal CD14(+) DCs controls CTL priming
    Jacques Banchereau
    Baylor Institute for Immunology Research and INSERM U899, Dallas, TX, USA
    Blood 119:5742-9. 2012
  7. pmc Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network
    Laurent Chorro
    Centre for Molecular and Cellular Biology of Inflammation, Division of Immunobiology, Infection, and Inflammatory Diseases, King s College London, London SE1 1UL, England, UK
    J Exp Med 206:3089-100. 2009
  8. pmc HIV-1 efficient entry in inner foreskin is mediated by elevated CCL5/RANTES that recruits T cells and fuels conjugate formation with Langerhans cells
    Zhicheng Zhou
    Mucosal Entry of HIV 1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, CNRS UMR 8104, Paris, France
    PLoS Pathog 7:e1002100. 2011
  9. ncbi Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling
    Saeko Nakajima
    Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Allergy Clin Immunol 129:1048-55.e6. 2012
  10. pmc Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells
    Eynav Klechevsky
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 29:497-510. 2008

Detail Information

Publications300 found, 100 shown here

  1. pmc IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
    Yaming Wang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Immunol 13:753-60. 2012
    ..b>Langerhans cells (LCs) and microglia develop from embryonic myeloid precursor cells that populate the epidermis and central ..
  2. pmc Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages
    Guillaume Hoeffel
    Singapore Immunology Network, Agency for Science, Technology and Research A STAR, Immunos Building 3 4, Biopolis, 138648, Singapore
    J Exp Med 209:1167-81. 2012
    b>Langerhans cells (LCs) are the dendritic cells (DCs) of the epidermis, forming one of the first hematopoietic lines of defense against skin pathogens...
  3. ncbi Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia
    Melanie Greter
    Institute of Experimental Immunology, Neuroimmunology, University of Zurich, Zurich, Switzerland
    Immunity 37:1050-60. 2012
    ..The development of both Langerhans cells (LCs) and microglia is highly dependent on Csf-1 receptor signaling but independent of Csf-1...
  4. pmc Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells
    Julien Seneschal
    Department of Dermatology Harvard Skin Disease Research Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    Immunity 36:873-84. 2012
    ..These underappreciated properties of LCs, namely maintenance of tolerance in normal skin, and activation of protective skin resident memory T cells upon infectious challenge, help clarify the role of LCs in skin...
  5. ncbi Langerhans cells renew in the skin throughout life under steady-state conditions
    Miriam Merad
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94304, USA
    Nat Immunol 3:1135-41. 2002
    b>Langerhans cells (LCs) are bone marrow (BM)-derived epidermal dendritic cells (DCs) that represent a critical immunologic barrier to the external environment, but little is known about their life cycle...
  6. pmc The differential production of cytokines by human Langerhans cells and dermal CD14(+) DCs controls CTL priming
    Jacques Banchereau
    Baylor Institute for Immunology Research and INSERM U899, Dallas, TX, USA
    Blood 119:5742-9. 2012
    We recently reported that human epidermal Langerhans cells (LCs) are more efficient than dermal CD14(+) DCs at priming naive CD8(+) T cells into potent CTLs...
  7. pmc Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network
    Laurent Chorro
    Centre for Molecular and Cellular Biology of Inflammation, Division of Immunobiology, Infection, and Inflammatory Diseases, King s College London, London SE1 1UL, England, UK
    J Exp Med 206:3089-100. 2009
    ..b>Langerhans cells (LCs) of the epidermis, although of myeloid origin, were shown to renew in tissues independently from the ..
  8. pmc HIV-1 efficient entry in inner foreskin is mediated by elevated CCL5/RANTES that recruits T cells and fuels conjugate formation with Langerhans cells
    Zhicheng Zhou
    Mucosal Entry of HIV 1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, CNRS UMR 8104, Paris, France
    PLoS Pathog 7:e1002100. 2011
    ..At this early time point, Langerhans cells (LCs) and T-cells within the inner foreskin epidermis are the first cells targeted by the virus...
  9. ncbi Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling
    Saeko Nakajima
    Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Allergy Clin Immunol 129:1048-55.e6. 2012
    ..The clarification of cutaneous dendritic cell subset and the role of thymic stromal lymphopoietin (TSLP) signaling in epicutaneous sensitization with protein antigens, as in the development of atopic dermatitis, is a crucial issue...
  10. pmc Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells
    Eynav Klechevsky
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 29:497-510. 2008
    ..the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207(+) Langerhans cells (LCs) and dermal CD14(+) DCs...
  11. pmc Langerhans cells are negative regulators of the anti-Leishmania response
    Kordula Kautz-Neu
    Department of Dermatology, Johannes Gutenberg University, 55131 Mainz, Germany
    J Exp Med 208:885-91. 2011
    ..Moreover, selective depletion of Langerhans cells (LCs) demonstrated that the absence of LCs, and not Langerin(+) dermal DC, was responsible for the reduced T ..
  12. pmc Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages
    Lisa C Zaba
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York 10021, USA
    J Clin Invest 117:2517-25. 2007
    ..In summary, the normal dermis contains typical immunostimulatory myeloid DCs identified by CD11c and BDCA-1, as well as an additional population of poorly stimulatory macrophages marked by CD163 and FXIIIA...
  13. ncbi Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells
    Rhys S Allan
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Science 301:1925-8. 2003
    The classical paradigm for dendritic cell function derives from the study of Langerhans cells, which predominate within skin epidermis...
  14. pmc CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells
    Sandrine Henri
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    J Exp Med 207:189-206. 2010
    Recent studies have challenged the view that Langerhans cells (LCs) constitute the exclusive antigen-presenting cells of the skin and suggest that the dermal dendritic cell (DDC) network is exceedingly complex...
  15. pmc Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 204:3133-46. 2007
    ..Langerin is used to identify human and mouse epidermal Langerhans cells (LCs), as well as migratory LCs in the dermis and the skin draining lymph nodes (DLNs)...
  16. ncbi Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
    Miriam Merad
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Rev Immunol 8:935-47. 2008
    b>Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and humans...
  17. ncbi TGF-beta is required to maintain the pool of immature Langerhans cells in the epidermis
    Junda M Kel
    Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Immunol 185:3248-55. 2010
    ..In conclusion, TGF-beta inhibits in vivo LC maturation and migratory phenotype, identifying TGF-beta as a critical factor controlling LC homeostasis in the steady state...
  18. ncbi From skin dendritic cells to a simplified classification of human and mouse dendritic cell subsets
    Martin Guilliams
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille Cedex 9, France
    Eur J Immunol 40:2089-94. 2010
    ....
  19. ncbi A lack of Birbeck granules in Langerhans cells is associated with a naturally occurring point mutation in the human Langerin gene
    Pauline Verdijk
    Department of Dermatology, Leiden University Mediacl Center, Wassenaarseweg 72, 2333, AL Leiden, The Netherlands
    J Invest Dermatol 124:714-7. 2005
    ..Expression of mutated Langerin in human fibroblasts induces tubular-like structures that are negative for BG-specific antibodies and do not resemble the characteristic structural features of BG...
  20. ncbi Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells
    Adrien Kissenpfennig
    Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Parc Scientifique et Technologique de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Immunity 22:643-54. 2005
    b>Langerhans cells (LCs) are prominent dendritic cells (DCs) in epithelia, but their role in immunity is poorly defined...
  21. ncbi Langerhans cells arise from monocytes in vivo
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Immunol 7:265-73. 2006
    b>Langerhans cells (LCs) are the only dendritic cells of the epidermis and constitute the first immunological barrier against pathogens and environmental insults...
  22. pmc External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers
    Akiharu Kubo
    Department of Dermatology, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Exp Med 206:2937-46. 2009
    ..How acquisition of external antigens (Ags) by epidermal Langerhans cells (LCs) occur despite these barriers has remained unknown...
  23. pmc Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity
    Clare L Bennett
    Department of Cell Biology and Histology, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
    J Cell Biol 169:569-76. 2005
    b>Langerhans cells (LC) form a unique subset of dendritic cells (DC) in the epidermis but so far their in vivo functions in skin immunity and tolerance could not be determined, in particular in relation to dermal DC (dDC)...
  24. pmc Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin
    Nikolaus Romani
    Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria
    Immunol Rev 234:120-41. 2010
    b>Langerhans cells (LCs) are antigen-presenting dendritic cells (DCs) that reside in epithelia. The best studied example is the LC of the epidermis...
  25. pmc CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire
    Annemieke de Jong
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:1102-9. 2010
    ..CD1a-autoreactive T cells homed to skin, where they produced interleukin 22 (IL-22) in response to CD1a on Langerhans cells. The strong and frequent responses among genetically diverse donors define CD1a-autoreactive cells as a ..
  26. ncbi Within 1 h, HIV-1 uses viral synapses to enter efficiently the inner, but not outer, foreskin mucosa and engages Langerhans-T cell conjugates
    Y Ganor
    Mucosal Entry of HIV 1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Mucosal Immunol 3:506-22. 2010
    ..with apical foreskin keratinocytes, leading to polarized budding of HIV-1, which is rapidly internalized by Langerhans cells (LCs) in the inner foreskin...
  27. ncbi Targeting skin dendritic cells to improve intradermal vaccination
    N Romani
    Department of Dermatology and Venereology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Curr Top Microbiol Immunol 351:113-38. 2012
    ..Several types of professional antigen-presenting cells inhabit the healthy skin. Epidermal Langerhans cells (CD207/langerin(+)), dermal langerin(neg), and dermal langerin(+) dendritic cells (DC) have been described, ..
  28. pmc Peptide-loaded Langerhans cells, despite increased IL15 secretion and T-cell activation in vitro, elicit antitumor T-cell responses comparable to peptide-loaded monocyte-derived dendritic cells in vivo
    Emanuela Romano
    Laboratory of Cellular Immunobiology, Immunology Program, Sloan Kettering Institute for Cancer Research, New York, New York, USA
    Clin Cancer Res 17:1984-97. 2011
    We compared the efficacy of human Langerhans cells (LC) as tumor immunogens in vivo with monocyte-derived dendritic cells (moDC) and investigated how interleukin 15 (IL15) supports optimal DC-stimulated antitumor immunity.
  29. ncbi Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells
    Kenji Kabashima
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Nat Med 9:744-9. 2003
    Antigen-specific immune responses in the skin are initiated by antigen uptake into Langerhans cells and the subsequent migration of these cells to draining lymph nodes...
  30. ncbi Langerhans cells and dendritic cells are cytotoxic towards HPV16 E6 and E7 expressing target cells
    I Caroline Le Poole
    Department of Pathology Oncology Institute, Loyola University Medical Center, Bldg 112, Rm 203, 2160 South 1st Ave, Maywood, IL 60153, USA
    Cancer Immunol Immunother 57:789-97. 2008
    ..It has not been investigated whether Langerhans cells (LC) are selectively cytotoxic to tumor cells...
  31. pmc Vaginal langerhans cells nonproductively transporting HIV-1 mediate infection of T cells
    Lamar Ballweber
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D3 100, Seattle, WA 98109 1024, USA
    J Virol 85:13443-7. 2011
    Although implied by other models, proof that Langerhans cells (LCs) in the human vagina participate in dissemination of infectious human immunodeficiency virus type 1 (HIV-1) has been lacking...
  32. ncbi Conditional deletion of TGF-βR1 using Langerin-Cre mice results in Langerhans cell deficiency and reduced contact hypersensitivity
    Sonja P Zahner
    Department of Immunology, Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands
    J Immunol 187:5069-76. 2011
    The critical role of Langerhans cells (LC) in contact hypersensitivity (CHS) was recently questioned in studies using different LC-depletion mouse models...
  33. pmc Langerhans cells facilitate epithelial DNA damage and squamous cell carcinoma
    Badri G Modi
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 335:104-8. 2012
    ..Mice lacking Langerhans cells (LCs), a signatory epidermal dendritic cell (DC), are protected from cutaneous chemical carcinogenesis, ..
  34. ncbi Epidermal langerhans cells are dispensable for humoral and cell-mediated immunity elicited by gene gun immunization
    Angelika Stoecklinger
    Christian Doppler Laboratory of Allergy Diagnostics and Therapy, Department of Molecular Biology, University Salzburg, Salzburg, Austria
    J Immunol 179:886-93. 2007
    ..Being the principal APC in the epidermis, Langerhans cells (LC) seem ideal candidates to accomplish these functions...
  35. pmc Langerhans cells as targets for immunotherapy against skin cancer
    Patrizia Stoitzner
    Department of Dermatology and Venereology, Innsbruck Medical University, Tirol, Austria
    Immunol Cell Biol 88:431-7. 2010
    ..in developing immunotherapeutical strategies against skin cancer in the context of our observations that Langerhans cells (LC) are very potent antigen presenting cells and are able to incorporate protein antigens and present them ..
  36. ncbi Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells, attenuates their maturation, and enhances their migratory and TGF-beta1 and IL-10-producing properties
    Jean Pierre Allam
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    J Allergy Clin Immunol 126:638-45.e1. 2010
    ..Oral mucosal Langerhans cells (oLCs) play a central role...
  37. pmc HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells
    Christopher Schuster
    Department of Dermatology, DIAID, 1090 Vienna, Austria
    J Exp Med 206:169-81. 2009
    ..Collectively, our data provide insight into skin DC biology and the mechanisms through which skin DCs presumably populate the skin during development...
  38. pmc Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells
    Carl E Allen
    Department of Pediatrics, Texas Children s Cancer Center and Hematology Service, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 184:4557-67. 2010
    ..cell histiocytosis (LCH) is a rare disease characterized by heterogeneous lesions containing CD207(+) Langerhans cells (LCs) and lymphocytes that can arise in almost any tissue and cause significant morbidity and mortality...
  39. pmc C-type lectin Langerin is a beta-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi
    Marein A W P de Jong
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Mol Immunol 47:1216-25. 2010
    b>Langerhans cells (LCs) lining the stratified epithelia and mucosal tissues are the first antigen presenting cells to encounter invading pathogens, such as viruses, bacteria and fungi...
  40. ncbi Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules
    J Valladeau
    Schering Plough Laboratory for Immunological Research, Dardilly, France
    Immunity 12:71-81. 2000
    ..identified a type II Ca2+-dependent lectin displaying mannose-binding specificity, exclusively expressed by Langerhans cells (LC), and named Langerin...
  41. ncbi Human Langerhans cells express a specific TLR profile and differentially respond to viruses and Gram-positive bacteria
    Vincent Flacher
    Laboratory for Immunological Research, Schering Plough, Dardilly, France
    J Immunol 177:7959-67. 2006
    ..In pluristratified epithelia, Langerhans cells (LC) are a critical subset of DC which take up Ags and migrate toward lymph nodes upon inflammatory stimuli...
  42. pmc Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells
    Daniel H Kaplan
    Department of Dermatology, 2Department of Laboratory Medicine, 3Section of Immunobiology, and 4Section of Medical Oncology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 204:2545-52. 2007
    b>Langerhans cells (LCs) are bone marrow (BM)-derived epidermal dendritic cells (DCs) that develop from precursors found in the dermis. Epidermal LCs are absent in transforming growth factor (TGF) beta1-deficient mice...
  43. ncbi CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions
    Lars Ohl
    Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany
    Immunity 21:279-88. 2004
    ..DC) into the lymphatic vessels within the dermis while this receptor is dispensable for the mobilization of Langerhans cells from the epidermis to the dermis...
  44. ncbi Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity
    Daniel H Kaplan
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 23:611-20. 2005
    Epidermal Langerhans cells (LCs), a distinct skin-resident dendritic cell population, acquire antigen in the skin and migrate to draining lymph nodes where they are thought to initiate adaptive immune responses...
  45. ncbi Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis
    Jessica Strid
    Peter Gorer Department of Immunobiology, King s College London School of Medicine at Guy s Hospital, London SE1 9RT, UK
    Nat Immunol 9:146-54. 2008
    ..changes in the organization of tissue-resident V(gamma)5V(delta)1 TCRgammadelta+ intraepithelial T cells and Langerhans cells, swiftly followed by epithelial infiltration by unconventional alphabeta T cells...
  46. ncbi ICSBP is critically involved in the normal development and trafficking of Langerhans cells and dermal dendritic cells
    Giovanna Schiavoni
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    Blood 103:2221-8. 2004
    ..Here, we analyzed the role of ICSBP in the development and trafficking of epidermal Langerhans cells (LCs) and dermal DCs and the implications for initiation of a competent immune response...
  47. ncbi Cutting edge: virus selectively primes human langerhans cells for CD70 expression promoting CD8+ T cell responses
    Angelic M G van der Aar
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Immunol 187:3488-92. 2011
    ..The two outermost compartments of skin are populated by different Ag-presenting dendritic cell types. Epidermal Langerhans cells (LCs) are evolutionarily adapted to the continuous presence of harmless skin commensals by the selective lack ..
  48. ncbi RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells
    L Wu
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    Immunity 9:839-47. 1998
    ..However, the deficiency in splenic CD8alpha- DEC-205- DC is a direct, stem cell intrinsic effect of the RelB mutation. Thus, RelB selectively regulates a myeloid-related DC lineage...
  49. ncbi Changing views of the role of Langerhans cells
    Nikolaus Romani
    Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria
    J Invest Dermatol 132:872-81. 2012
    b>Langerhans cells (LCs) have long been considered to be the major sensitizing cells in the skin by initiating productive immunity in naive resting T cells. This picture has changed over the past decade...
  50. pmc Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo
    Maria R Gaiser
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:E889-97. 2012
    After activation, Langerhans cells (LC), a distinct subpopulation of epidermis-resident dendritic cells, migrate from skin to lymph nodes where they regulate the magnitude and quality of immune responses initiated by epicutaneously ..
  51. ncbi A postmigrational switch among skin-derived dendritic cells to a macrophage-like phenotype is predetermined by the intracutaneous cytokine balance
    Tanja D de Gruijl
    Department of Medical Oncology, Division of Immunotherapy, VU University Medical Center, Amsterdam, The Netherlands
    J Immunol 176:7232-42. 2006
    ....
  52. pmc Impaired Langerhans cell migration in psoriasis
    Marie Cumberbatch
    Syngenta Central Toxicology Laboratory, Macclesfield, Cheshire, SK10 4TJ, England, UK
    J Exp Med 203:953-60. 2006
    ..Although a role for altered dynamics of LC migration/turnover has not been formally excluded, these data reveal a very consistent decrement of LC function in psoriasis that may play a decisive role in disease pathogenesis...
  53. pmc Langerhans cells require MyD88-dependent signals for Candida albicans response but not for contact hypersensitivity or migration
    Krystal Haley
    Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 188:4334-9. 2012
    b>Langerhans cells (LC) are a subset of skin-resident dendritic cells (DC) that reside in the epidermis as immature DC, where they acquire Ag...
  54. ncbi Two distinct types of Langerhans cells populate the skin during steady state and inflammation
    Kristin Seré
    Institute for Biomedical Engineering, Department of Cell Biology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany
    Immunity 37:905-16. 2012
    b>Langerhans cells (LCs), the dendritic cells (DCs) in skin epidermis, possess an exceptional life cycle and developmental origin...
  55. ncbi Identification of lineage relationships and novel markers of blood and skin human dendritic cells
    Andrew N Harman
    Westmead Millennium Institute, Westmead, New South Wales 2145, Australia
    J Immunol 190:66-79. 2013
    ..We also compared these with monocyte-derived DCs (MDDCs) and MUTZ3 Langerhans cells (LCs) to investigate their relevance as model skin DCs...
  56. pmc Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells
    Robert E Hunger
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles UCLA, Los Angeles, California 90095, USA
    J Clin Invest 113:701-8. 2004
    b>Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin...
  57. pmc Differential capacity of human skin dendritic cells to polarize CD4+ T cells into IL-17, IL-21 and IL-22 producing cells
    Karine Penel-Sotirakis
    Universite de Lyon, Hopital E Herriot, Lyon, France
    PLoS ONE 7:e45680. 2012
    ..e., epidermal Langerhans cells (LCs), dermal CD1c(+)CD14(-) and CD14(+) DCs (DDCs)...
  58. pmc CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells
    Kenji Kabashima
    Department of Dermatology, University of Environmental and Occupational Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Am J Pathol 171:1249-57. 2007
    ..Among FITC(+) cells, Langerin(+) Langerhans cells and Langerin(-) (dermal) dDC subsets were detected as CD11c(high+)CD11b(int+) cells and CD11c(high+)CD11b(..
  59. ncbi Stromal CD10 expression, as well as increased dermal macrophages and decreased Langerhans cells, are associated with malignant transformation of keratinocytes
    Masakazu Takahara
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Cutan Pathol 36:668-74. 2009
    ..We analyzed CD10+ stromal cells, dermal macrophages and Langerhans cells (LCs) in skin tumors.
  60. pmc Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10
    Botond Z Igyarto
    Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 183:5085-93. 2009
    Mice lacking epidermal Langerhans cells (LC) develop exaggerated contact-hypersensitivity (CHS) responses due to the absence of LC during sensitization/initiation...
  61. ncbi The actin-bundling protein fascin is involved in the formation of dendritic processes in maturing epidermal Langerhans cells
    R Ross
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Immunol 160:3776-82. 1998
    Dendritic cells (DC) are characterized by their unique potential to prime naive T cells. Epidermal Langerhans cells (LC), the DC resident in the epidermis, gain this immunostimulatory capacity following Ag contact in vivo or during in ..
  62. pmc Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice
    Christian Wohn
    Department of Immunology, Erasmus MC, University Medical Center, 3015 GE, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 110:10723-8. 2013
    ..These results suggest therapeutic targeting of IL-23 production by cDCs to refine current treatment strategies for psoriasis. ..
  63. ncbi Development and homeostasis of 'resident' myeloid cells: the case of the Langerhans cell
    Laurent Chorro
    Centre for Molecular and Cellular Biology of Inflammation CMCBI, New Hunt s House, King s College London, Great Maze Pond, SE1 1UL, London, UK
    Trends Immunol 31:438-45. 2010
    b>Langerhans cells (LCs) are myeloid cells of the epidermis, featured in immunology textbooks as bone marrow-derived antigen-presenting dendritic cells (DCs)...
  64. pmc Epidermal Langerhans cells rapidly capture and present antigens from C-type lectin-targeting antibodies deposited in the dermis
    Vincent Flacher
    Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria
    J Invest Dermatol 130:755-62. 2010
    ..These include different dendritic cells (DCs) such as epidermal Langerhans cells (LCs), dermal DCs, and dermal langerin+ DCs...
  65. ncbi Skin-derived dendritic cells can mediate deletional tolerance of class I-restricted self-reactive T cells
    Jason Waithman
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
    J Immunol 179:4535-41. 2007
    ..Some of these are migratory, such as the skin-derived epidermal Langerhans cells and a separate dermal DC subset, whereas others are lymphoid resident in nature, such as the CD8+ DCs found ..
  66. ncbi Loss of epidermal Langerhans cells occurs in human papillomavirus alpha, gamma, and mu but not beta genus infections
    Cheng Mee Leong
    Department of Microbiology, University of Otago, Dunedin, New Zealand
    J Invest Dermatol 130:472-80. 2010
    ..b>Langerhans cells (LC), the only epidermal professional antigen-presenting cells, are readily detected in normal mucosal and ..
  67. ncbi Ontogeny and homeostasis of Langerhans cells
    Florent Ginhoux
    Singapore Immunology Network SIgN, Agency for Science, Technology and Research A STAR, Immunos, Biopolis, Singapore
    Immunol Cell Biol 88:387-92. 2010
    b>Langerhans cells (LCs) refer to the dendritic cells (DCs) that populate the epidermis...
  68. pmc In vivo function of Langerhans cells and dermal dendritic cells
    Daniel H Kaplan
    Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, MN 55414, USA
    Trends Immunol 31:446-51. 2010
    ..We describe a model in which the two best-characterized skin-resident DCs, langerhans cells (LCs) and Langerin(+) dermal DCs (dDCs) have distinct functions: Langerin(+) dDCs initiate and LCs suppress T ..
  69. ncbi Langerhans cell sarcoma involving gallbladder and peritoneal lymph nodes: a case report
    Gang Zhao
    Department of General Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Int J Surg Pathol 17:347-53. 2009
    Langerhans cell sarcoma (LCS) is a rare proliferation of Langerhans cells with overtly malignant cytologic features and spreads aggressively. LCSs show a multiorgan involvement, including skin, lymph nodes, lung, and bone...
  70. pmc Langerhans cells are precommitted to immune tolerance induction
    Elena Shklovskaya
    T Cell Biology Research Program, Centenary Institute of Cancer Medicine and Cell Biology, Newtown NSW 2042, Australia
    Proc Natl Acad Sci U S A 108:18049-54. 2011
    ..Here, we tested whether epidermal Langerhans cells (LCs) can support immunogenic responses in vivo in the absence of antigen presentation by other DC subsets...
  71. ncbi Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission
    Lot de Witte
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Trends Mol Med 14:12-9. 2008
    ..In the genital tissues, two different DC subsets are present: the Langerhans cells (LCs) and the DC-SIGN(+)-DCs...
  72. ncbi The skin barrier, atopic dermatitis and allergy: a role for Langerhans cells?
    Robin E Callard
    Immunobiology Unit, Institute of Child Health, University College London, London, UK, WC1N 1EH
    Trends Immunol 28:294-8. 2007
    ..b>Langerhans cells take up antigen applied to skin from which the skin barrier has been removed; they then migrate to draining ..
  73. ncbi Dicer-dependent microRNAs control maturation, function, and maintenance of Langerhans cells in vivo
    Harmjan Kuipers
    Institute for Immunology, Ludwig Maximilian University Munich, Munich, Germany
    J Immunol 185:400-9. 2010
    ..In contrast to the differentiation of epidermal Langerhans cells (LCs) and their seeding into the epidermis, LC maturation, turnover, and MHC class II Ag presentation ..
  74. ncbi Characterization of carbohydrate recognition by langerin, a C-type lectin of Langerhans cells
    Nicola S Stambach
    Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Glycobiology 13:401-10. 2003
    Langerin is a type II transmembrane cell surface receptor found on Langerhans cells. The extracellular domain of langerin consists of a neck region containing a series of heptad repeats and a C-terminal C-type carbohydrate-recognition ..
  75. pmc Cigarette smoke promotes dendritic cell accumulation in COPD; a Lung Tissue Research Consortium study
    Robert Vassallo
    The Thoracic Diseases Research Unit, Division of Pulmonary Critical Care, Department of Internal Medicine, the Clinical Immunology and Immunotherapeutics Program, Mayo Clinic and Foundation, Rochester, Minnesota, 55905, USA
    Respir Res 11:45. 2010
    ..Although evident that cigarette smoke, the primary cause of COPD, significantly influences dendritic cell functions, little is known about the roles of dendritic cells in the pathogenesis of COPD...
  76. pmc Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production
    Hideki Fujita
    Laboratory for Investigative Dermatology and Translational Immunomonitoring Resource Center, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:21795-800. 2009
    ..Using FACS, we isolated Langerhans cells (LCs; HLA-DR(+)CD207(+) cells) and dermal DCs (HLA-DR(hi)CD11c(+)BDCA-1(+) cells) from normal human epidermis ..
  77. ncbi Langerhans cells and viral immunity
    Anthony L Cunningham
    Centre for Virus Research, Westmead Millennium Institute and University of Sydney, Westmead, Sydney, Australia
    Eur J Immunol 38:2377-85. 2008
    b>Langerhans cells (LC) are a unique dendritic cell subset that are located in mucosal stratified squamous epithelium and skin epidermis...
  78. pmc Functional redundancy of Langerhans cells and Langerin+ dermal dendritic cells in contact hypersensitivity
    Madelon Noordegraaf
    Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Invest Dermatol 130:2752-9. 2010
    The relative roles of Langerhans cells (LC), dermal dendritic cells (DC), and, in particular, the recently discovered Langerin(+) dermal DC subset in the induction and control of contact hypersensitivity (CHS) responses remain ..
  79. ncbi Human immunodeficiency virus-1 acquisition in genital mucosa: Langerhans cells as key-players
    M A W P de Jong
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Intern Med 265:18-28. 2009
    ..b>Langerhans cells (LCs) are professional antigen presenting cells lining the mucosal stratified squamous epithelium...
  80. ncbi A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily
    L J Zhou
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115 6084
    J Immunol 149:735-42. 1992
    ..HB15 was also expressed by Langerhans cells within the skin...
  81. ncbi Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4⁺ T cells but are incapable of cross-presentation
    Michiel van der Vlist
    Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 41:2619-31. 2011
    b>Langerhans cells (LCs) are a subset of DCs that reside in the upper respiratory tract and are ideally suited to sense respiratory virus infections...
  82. pmc Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8(+) T cells and activating Foxp3(+) regulatory T cells
    Mercedes Gomez de Agüero
    INSERM, U851, Lyon, France
    J Clin Invest 122:1700-11. 2012
    ..2,4-dinitrothiocyanobenzene (DNTB), that cutaneous immune tolerance in mice critically depends on epidermal Langerhans cells (LCs), which capture DNTB and migrate to lymph nodes for direct presentation to CD8(+) T cells...
  83. ncbi Insight into the immunobiology of human skin and functional specialization of skin dendritic cell subsets to innovate intradermal vaccination design
    M B M Teunissen
    Department of Dermatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Curr Top Microbiol Immunol 351:25-76. 2012
    ..This knowledge is critical for the development of intradermal vaccine strategies and supports the concept of intradermal vaccination as a superior route to the conventional intramuscular or subcutaneous methods...
  84. pmc Transforming growth factor beta1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells
    F Geissmann
    Service d Anatomie Pathologique, Hopital Necker Enfants Malades, Paris, France
    J Exp Med 187:961-6. 1998
    b>Langerhans cells (LCs) are dendritic cells (DCs) that are present in the epidermis, bronchi, and mucosae. Although LCs originate in bone marrow, little is known about their lineage of origin...
  85. ncbi Gram-positive bacteria enhance HIV-1 susceptibility in Langerhans cells, but not in dendritic cells, via Toll-like receptor activation
    Youichi Ogawa
    Department of Dermatology, University of Yamanashi, Japan
    Blood 113:5157-66. 2009
    ..Because Langerhans cells (LCs) are suspected to be the initial HIV targets after sexual exposure, we studied whether microbial ..
  86. ncbi TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23
    Ehsan Aliahmadi
    Charite University Medicine Berlin, Institute of Molecular Biology and Bioinformatics, Berlin, Germany
    Eur J Immunol 39:1221-30. 2009
    The cytokines IL-6, IL-1beta, TGF-beta, and IL-23 are considered to promote Th17 commitment. Langerhans cells (LC) represent DC in the outer skin layers of the epidermis, an environment extensively exposed to pathogenic attack...
  87. pmc Targeting of antigens to skin dendritic cells: possibilities to enhance vaccine efficacy
    Nikolaus Romani
    Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria
    Immunol Cell Biol 88:424-30. 2010
    ..Professional antigen-presenting cells of the skin comprise epidermal Langerhans cells (CD207/langerin(+)), dermal langerin(-) and dermal langerin(+) dendritic cells (DCs)...
  88. ncbi Loss of TLR2, TLR4, and TLR5 on Langerhans cells abolishes bacterial recognition
    Angelic M G van der Aar
    Department of Dermatology and
    J Immunol 178:1986-90. 2007
    It is unknown whether closely related epidermal dendritic cells, Langerhans cells (LCs), and dermal dendritic cells (DDCs) have unique functions...
  89. pmc Decreased migration of Langerhans precursor-like cells in response to human keratinocytes expressing human papillomavirus type 16 E6/E7 is related to reduced macrophage inflammatory protein-3alpha production
    Jennifer C Guess
    Department of Microbiology and Immunology, University of Rochester, New York 14642, USA
    J Virol 79:14852-62. 2005
    ..HPV infects cutaneous or mucosal epithelium, tissue that is monitored for microbial infection or damage by Langerhans cells. In lesions produced by HPV type 16, there is a reduction in numbers of immune cells, especially Langerhans ..
  90. pmc Depletion of Langerhans cells in human papillomavirus type 16-infected skin is associated with E6-mediated down regulation of E-cadherin
    Kate Matthews
    Virus Research Unit, Department of Microbiology, Malaghan Institute of Medical Research, Wellington School of Medicine, University of Otago, Dunedin, New Zealand
    J Virol 77:8378-85. 2003
    ..Intraepithelial Langerhans cells (LC) are antigen-presenting cells that are critical in T-cell priming in response to viral infections of the ..
  91. ncbi Thymic stromal lymphopoietin converts human epidermal Langerhans cells into antigen-presenting cells that induce proallergic T cells
    Susanne Ebner
    Department of Dermatology and Venereology, Kompetenzzentrum Medizin Tirol, Innsbruck, Austria
    J Allergy Clin Immunol 119:982-90. 2007
    ..TSLP is present at high levels in the epidermis of atopic dermatitis where it appears to trigger emigration of epidermal Langerhans cells (LCs); however, nothing else is known about the influence of TSLP on LCs.
  92. ncbi Langerin is a natural barrier to HIV-1 transmission by Langerhans cells
    Lot de Witte
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, van de Boechorstraat 7, 1081BT Amsterdam, The Netherlands
    Nat Med 13:367-71. 2007
    ..However, the epithelial Langerhans cells (LCs) are the first DC subset to encounter HIV-1...
  93. pmc Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1
    Florian Hladik
    Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Immunity 26:257-70. 2007
    ..T cells almost exclusively by CD4 and CCR5 receptor-mediated direct fusion, without requiring passage from Langerhans cells, and overt productive infection ensued...
  94. ncbi Evidence that Langerhans cells in adult pulmonary Langerhans cell histiocytosis are mature dendritic cells: importance of the cytokine microenvironment
    A Tazi
    Institut National de la Santé et de la Recherche Médicale U82, Unité de Formation et de Recherche Xavier Bichat, Paris, France
    J Immunol 163:3511-5. 1999
    Because Langerhans cells (LC) in peripheral tissues are generally "immature" cells with poor lymphostimulatory activity, the contribution of immune responses initiated by LC to the pathogenesis of pulmonary LC histiocytosis (LCH) has been ..
  95. pmc Langerhans cells and dermal dendritic cells capture protein antigens in the skin: possible targets for vaccination through the skin
    Florian Sparber
    Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria
    Immunobiology 215:770-9. 2010
    ..Dendritic cells of the skin, including epidermal Langerhans cells, langerin(+) and langerin(negative) dermal dendritic cells are ideally positioned to take up pathogens that ..
  96. pmc Reciprocal roles for CCAAT/enhancer binding protein (C/EBP) and PU.1 transcription factors in Langerhans cell commitment
    Atsushi Iwama
    Department of Immunology, Institute of Basic Medical Sciences, Core Research for Evolutional Science and Technology CREST Program of Japan Science and Technology JST
    J Exp Med 195:547-58. 2002
    ..Our findings establish reciprocal roles for C/EBP and PU.1 in LC development, and provide new insight into the molecular mechanism of LC development, which has not yet been well characterized...
  97. pmc Binding of live conidia of Aspergillus fumigatus activates in vitro-generated human Langerhans cells via a lectin of galactomannan specificity
    F Persat
    EA 3087, Universite Claude Bernard, Lyon, France and Unité INSERM 346, Lyon, France
    Clin Exp Immunol 133:370-7. 2003
    ..This study investigated the primary contact between Langerhans cells (LC), corresponding to dendritic cells present in pulmonary mucosa and live conidia of A. fumigatus...
  98. pmc Paclitaxel- and vincristine-evoked painful peripheral neuropathies: loss of epidermal innervation and activation of Langerhans cells
    Chiang Siau
    Department of Anesthesia, McGill University, Montreal, Quebec, Canada
    Exp Neurol 201:507-14. 2006
    ..Because complete and partial nerve transections are known to cause an increase in PGP9.5 in epidermal Langerhans cells (LCs), we also examined whether this effect occurs in chemotherapy-treated animals...
  99. ncbi Tumor necrosis factor, interleukin 11, and leukemia inhibitory factor produced by Langerhans cells in Langerhans cell histiocytosis
    Ulrika Andersson By
    Childhood Cancer Research Unit, Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    J Pediatr Hematol Oncol 26:706-11. 2004
    ....
  100. ncbi Distribution of Langerhans cells and mast cells within the human oral mucosa: new application sites of allergens in sublingual immunotherapy?
    J P Allam
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Allergy 63:720-7. 2008
    ..While antigen-presenting cells such as Langerhans cells (LCs) are thought to contribute to the effectiveness of SLIT, mast cells (MCs) most likely account for ..
  101. ncbi Glucocorticosteroids modify Langerhans cells to produce TGF-β and expand regulatory T cells
    Georg Stary
    Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, 1090 Vienna, Austria
    J Immunol 186:103-12. 2011
    ..Notably, we observed increased numbers of dermal FOXP3(+)CD25(+) T cells and epidermal Langerhans cells (LCs) that were associated with upregulated mRNA expression of TGF-β in lesions of GCS-treated Ni-allergic ..

Research Grants65

  1. LANGERHANS CELLS AND NERVES: BIDIRECTIONAL SIGNALING
    Richard Granstein; Fiscal Year: 2009
    ..One system that is amenable to establishing mechanistic links is the cutaneous immune system. In the skin, Langerhans cells (LCs), antigen presenting cells in the epidermis, are innervated...
  2. Nanopolymersomes for Transcutaneous Co-Delivery of Vaccine Antigens and Adjuvants
    PAUL CAMILLE TUMEH; Fiscal Year: 2013
    ..and efficacy of current vaccines by enhancing cell-mediated immunity through targeting of the epidermal Langerhans cells (LCs), and 2) enabling existing vaccine antigens to be co-delivered with adjuvant by a needle-free route...
  3. C5a as an Anti-HIV Microbicidal Candidate
    PHILIPPE ANDRE GALLAY; Fiscal Year: 2013
    ..transmigration of HIV through primary human genital epithelial cells;v) blocks infection of dendritic and Langerhans cells ex vivo (skin tissues);vi) prevents HIV transfer from dendritic and Langerhans cells to T cells ex vivo;vii) ..
  4. Regulation of TSLP receptor expression and function in eczema in mice and man
    Steven F Ziegler; Fiscal Year: 2013
    ..In Aim 3, the role of epidermal and dermal DCs in TSLP-driven inflammation will be examined in mice that lack Langerhans cells or CD11c+ DCs...
  5. miRNAs and epidermal langerhans cell development and function
    Qing Sheng Mi; Fiscal Year: 2011
    ..b>Langerhans cells (LCs) are skin-resident DCs that express the C-type lectin Langerin and have a life cycle distinct from many ..
  6. Characterizing a New Human Dendritic Cell Lineage and Its Role in LCH
    Miriam Merad; Fiscal Year: 2013
    ..paradigm suggests that LCH results from an accumulation of epidermal dendritic cells (DCs) also called "Langerhans cells" (LCs)...
  7. Mechanisms used by skin dendritic cells to induce regulatory T cells
    Juliana Idoyaga; Fiscal Year: 2013
    ..The DC system is intricate and is comprised of distinct subsets such as, skin migratory Langerhans cells, skin migratory classical dermal DCs and CD103+ dermal DCs, and tissue-resident DCs...
  8. MELANOMA VACCINES USING MHC-ASSOCIATED PEPTIDES
    CRAIG LEE SLINGLUFF; Fiscal Year: 2012
    ..is that antigen delivered with an adjuvant creates an inflammatory stimulus, which in turn induces epidermal Langerhans cells to mature and to migrate to draining lymph nodes...
  9. CD1 presentation of self glycolipids and lipopeptides to T cells
    DAVID BRANCH MOODY; Fiscal Year: 2013
    ..However, new evidence shows that cellular lipids activated T cells when bound to CD1 proteins expressed on Langerhans cells and other dendritic cells...
  10. Immunotherapeutic HPV cancer vaccines that target Langerhans cells
    Gerard Zurawski; Fiscal Year: 2010
    ..Based upon the recent progresses made in DC biology, we intend to develop vaccines that target Langerhans cells (LCs). LCs and interstitial DCs (intDCs) in human skin differ in their capacity to activate lymphocytes...
  11. Use of Substance P antagonists to regulate the skin immune function
    Adriana T Larregina; Fiscal Year: 2013
    ..of effector T cells, in CHS requires immunostimulatory skin dendritic cells DCs (sDCs) including epidermal Langerhans cells (LCs) and dermal DCs (DDCs) that transport haptens to skin draining lymph nodes (sDLNs) and activate naive T ..
  12. Exploration of novel pan-HPV treatments to block development of AIDS-associated c
    Wijbe Martin Kast; Fiscal Year: 2010
    ..which HPV escapes immunity is inducing tolerance via antigen presentation in the absence of co-stimulation by Langerhans cells (LC), the antigen-presenting cells at the site of HPV and HIV infection...
  13. Role of Langerhans Cells in the Cutaneous Immune System
    Daniel H Kaplan; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Langerhans cells and other skin dendritic cells are critical components of the immune system in the skin...
  14. Pathogenesis of Lupus Dermatitis
    Ram Raj Singh; Fiscal Year: 2013
    ..Skin has a specialized immune system that includes specialized dendritic cells called Langerhans cells (LC) and specialized 34 T cells called dendritic epidermal T cells (DETC)...
  15. Dendritic Cell Targeting Enhances Flavivirus Vaccine Efficacy
    Gregg Milligan; Fiscal Year: 2009
    ..Intriguingly, WNV does not productively infect pDCs. We hypothesize that WNV infects DCs (likely Langerhans cells) in the periphery, leading to their migration to the LN where they activate pDCs and recruit T and B cells...
  16. Innate Mechanisms Regulating CD8+ T Cell Immunity
    ROBERT LESLIE FAIRCHILD; Fiscal Year: 2010
    ..MIP-2/CXCL2 mediated neutrophil recruitment during hapten sensitization on the function of hapten-presenting Langerhans cells and the development of hapten-specific T cells to distinct cytokine producing phenotypes...
  17. ALTERATION WITH AGE OF RESISTANCE TO EYE INFECTIONS
    Linda D Hazlett; Fiscal Year: 2013
    ..of adhesion molecules, decreases the migration/persistence of inflammatory cells (PMN, M[unreadable], Langerhans cells) in the infected cornea;and promotes restoration of corneal homeostasis and re-modeling of the ECM, 2) to ..
  18. CYTOTOXIC T CELL RESPONSES TO HHV-8
    Charles R Rinaldo; Fiscal Year: 2013
    ..We will address the role of the major types of myeloid DC - monocyte-derived DC, Langerhans cells and dermal DC, and B cells - in priming na[unreadable]ve CD8 T cells and activation of memory T cells using ..
  19. Modulation of Hormonal and Systemic Immunity by Hormonal Contraceptive Use
    Thomas L Cherpes; Fiscal Year: 2013
    ..LNG-IUD use elicits any decreases in cervical epithelial layer thickness or any increases in the exposure of Langerhans cells to the mucosal surface...
  20. Improving the Efficacy of Dendritic Cell Vaccines
    JACQUES F BANCHEREAU; Fiscal Year: 2010
    ..Melanoma studies will determine the activity of "composite DCs," i.e., Langerhans cells and other subsets...
  21. HPV VLP AND ANTIGEN PRESENTING CELLS
    Wijbe Martin Kast; Fiscal Year: 2013
    ..which HPV escapes immunity is inducing tolerance via antigen presentation in the absence of co-stimulation by Langerhans cells (LC), the antigen-presenting cells at the site of HPV infections...
  22. Redefining Langerhans Cell Histiocytosis as a Myeloid Dysplasia and Identifying B
    Carl E Allen; Fiscal Year: 2013
    ..The current model of LCH suggests that pathologic Langerhans cells in LCH lesions arise due to malignant transformation of epidermal Langerhans cells...
  23. Local Immunoregulation of Carcinogenesis
    Michael Girardi; Fiscal Year: 2013
    ..by repeated applications of a pro-inflammatory tumor promoter, TPA, we observed that mice deficient in Langerhans cells (LC) are markedly resistant to tumor formation, and our findings have suggested an under- emphasized role of ..
  24. THE ROLE OF IL-34 IN THE BIOLOGY OF LANGERHANS CELLS
    Marco Colonna; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): PROJECT SUMMARY Langerhans cells (LCs) are the dendritic cells of the skin epidermis that detect physical, chemical and microbial injuries and promote immune responses...
  25. Enhancing HPV-16 E6/E7 Specific Antitumor Immunity
    Tzyy Choou Wu; Fiscal Year: 2013
    ..Specifically, we plan to Aim 1: Optimize DNA transduction of mouse keratinocytes, Langerhans cells and/or dermal DCs in mouse skin by infection with skin-tropic HPV-2/4 pseudovirions carrying a marker gene ..
  26. HPV-Specific, Immune Suppression in Patients with RRP
    VINCENT ROBERT BONAGURA; Fiscal Year: 2013
    ..and exogenous PGE2 on maturation and the expression of pro/anti-inflammatory cytokine/chemokines by Langerhans cells;2): Determine the signal transduction pathways that mediate expression and release of IL-36[unreadable] in ..
  27. Behavioral dynamics of Langerhans cells in skin
    Akira Takashima; Fiscal Year: 2010
    b>Langerhans cells (LCs) are immature dendritic cell (DC) subsets that perform two key surveillance tasks (antigen sampling and detection of danger signals) at the environmental interface...
  28. Regulation of Immune Responses by IgE and Mast Cells
    Hans Oettgen; Fiscal Year: 2009
    ..the effects of mast cells and of mast cell-derived cytokines TNF and IL-6 on dermal dendritic cells and Langerhans cells. ll...
  29. Reprogramming Host Immune Responses to Cure or Control Persistent HPV Infection
    VINCENT ROBERT BONAGURA; Fiscal Year: 2013
    ..for release of IL-36? from HPV-infected laryngeal keratinocytes, and whether IL-36? can activate/mature Langerhans cells from RRP patients;2) Determine if Tregs from RRP patients can be reprogrammed to become TH17-like T-cells ..
  30. GENETIC MODIFICATION OF HUMAN DENDRITIC CELLS FOR CANCER IMMUNITY
    JAMES WILLIAM YOUNG; Fiscal Year: 2012
    ..We will introduce IL-12p70 by genetic alteration of Langerhans cells to stimulate and harness the adjuvant properties of natural killer (NK) cells...
  31. NK Tolerance and Hematopoietic Cell Transplantation
    Katharine C Hsu; Fiscal Year: 2012
    ..cultured during development in an environment expressing non-self class I ligands as presented by allogeneic Langerhans cells or stromal cell transfectants...
  32. Regulation of Langerhans Cell Migration by Invariant Gamma Delta T Cells
    PETER JUNGHAN KIM; Fiscal Year: 2013
    ..Recent studies have pointed to Langerhans cells as important regulators of skin tolerance...
  33. Hyaluronan-mediated regulation of Langerhans cells
    Mark Mummert; Fiscal Year: 2009
    ..Once we have determined the optimal Pep-1 concentrations and time-to-imaging we will examine the utility of Pep-1 to detect spontaneous MM metastasis in mice. ..
  34. The Role of Exosomes in Semen for HIV Infection in the Genital Mucosa of Women
    Florian Hladik; Fiscal Year: 2012
    ..Moreover, seminal exosomes rapidly enter vaginal Langerhans cells (LCs) upon contact...
  35. DENDRITIC CELLS AND THE PATHOGENESIS OF HIV-1 INFECTION
    Ralph M Steinman; Fiscal Year: 2010
    ..We will study HIV-1 pathogenesis in the context of 3 major DC subsets: monocyte-derived DCs, Langerhans cells, and new plasmacytoid cells...
  36. Regulated Activation of Latent-TGFb Determines Langerhans Cell Migration
    Daniel H Kaplan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Langerhans cells (LC) reside in the epidermis of the skin--a barrier site that provides LC access to cutaneous pathogens and neoplasia as well as benign commensal microorganisms...
  37. CD1-RESTRICTED T CELL RESPONSES IN SKIN
    Robert L Modlin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Langerhans cells (LC) constitute a subset of dendritic cells (DC) that initiate innate immune responses in skin, and are able to instruct the acquired T cell response by the presentation of peptide ..
  38. STRUCTURE AND REGULATION OF THE CD1 MULTIGENE FAMILY
    PAUL BLEICHER; Fiscal Year: 1992
    Immunity in the skin is mediated by T lymphocytes and Langerhans cells. These cells also are central to the pathogenesis of a large number of inflammatory and malignant diseases such as lupus erythematosus, lichen planus, cutaneous T cell ..
  39. Microbicide delivery system to target lymphoid organs
    Mohamed E Labib; Fiscal Year: 2013
    ..It has been shown that Langerhans cells (LC) and dendritic cells (DC) capture the virus either from the vaginal surface or from top epithelium layers ..
  40. TUMOR IMMUNITY GENERATED BY DENDRITIC CELLS
    JAMES WILLIAM YOUNG; Fiscal Year: 2010
    ..We will compare distinct populations of monocyte-derived dendritic cells with Langerhans cells or dermal-interstitial dendritic cells generated from CD34+ progenitors to test this unifying concept of ..
  41. Microbicide delivery system to target lymphoid organs
    Mohamed E Labib; Fiscal Year: 2010
    ..It has been shown that Langerhans cells (LC) and dendritic cells (DC) capture the virus either from the vaginal surface or from top epithelium layers ..
  42. Induction of Th 17 immunity by different cutaneous dendritic cell populations
    Alicia R Mathers; Fiscal Year: 2011
    ..Furthermore, she has demonstrated that epidermal resident Langerhans cells (LCs), and not dermal DCs (DDCs), are the cutaneous DC subset responsible for initiating Th17 immunity...
  43. Dendritic cell targeted hepatitis c virus immunotherapy
    Tyler Curiel; Fiscal Year: 2003
    ..g., Langerhans Cells (LCs). Recently we showed that LCs can be generated by culturing monocytes with GM-CSF+IL15...
  44. MODULATION OF LANGERHANS CELL FUNCTION BY UVB RADIATION
    Paul Bergstresser; Fiscal Year: 2004
    ..This competitive renewal proposes to continue work on the effects of UVR on Langerhans cells (LC) and on immunity in skin...
  45. ANTIGEN IMMUNOSUPPRESSION BY KILLER LANGERHANS CELLS
    Akira Takashima; Fiscal Year: 2004
    b>Langerhans cells (LC) ordinarily deliver activation signals to T cells...
  46. TRANSPLANTATION OF ALLOGENEIC SKIN EQUIVALENTS
    Barbara Hull; Fiscal Year: 1993
    ..Depletion of the Ia antigen+ Langerhans cells from the epidermal suspension used to construct the skin equivalents does not prolong the survival of the ..
  47. CUTANEOUS BIOLOGY OF NITRIC OXIDE
    Ethan Lerner; Fiscal Year: 2002
    ..In conventional mice, iNOS is expressed in Langerhans cells (LC). NO is also produced by the LC-like cell line XS-52...
  48. FUNCTION OF FCERI ON EPIDERMAL LANGERHANS CELLS
    TERESA BORKOWSKI; Fiscal Year: 2001
    ..This application constitutes a request for the fifth year of funding. Langerhans cells (LC) are the principal antigen presenting cells in the skin and part of the network of professional antigen ..
  49. IMMUNOPHYSIOLOGY OF KERATINOCYTE CYTOKINES
    Thomas Kupper; Fiscal Year: 1999
    ..Skin, oral, and genital mucosal dendritic cells, which include both Langerhans cells and dermal dendritic cells, appear to belong to a distinct bone marrow/-derived lineage and are highly ..
  50. HIV INDUCED SYNCYTIA AND THE ORAL MANIFESTATIONS OF AIDS
    David Soll; Fiscal Year: 1999
    ..Furthermore, syncytium formation may serve as an indication of HIV progression. ..
  51. Molecular Pathobiology of Langerhans Cell Histiocytosis
    Barrett Rollins; Fiscal Year: 2007
    ..LCH) is a disease in which tissue destruction is caused by accumulation of histiocytes derived from Langerhans cells (LC), the antigen presenting dendritic cells of skin...
  52. Molecular Pathobiology of Langerhans Cell Histiocytosis
    Barrett Rollins; Fiscal Year: 2002
    ..LCH) is a disease in which tissue destruction is caused by accumulation of histiocytes related to Langerhans cells (LC), the antigen presenting dendritic cells of skin...
  53. REGULATION OF LANGERHANS CELL FUNCTION
    Richard Granstein; Fiscal Year: 1999
    ..Of particular interest, dendritic epidermal antigen presenting cells (Langerhans cells, LC) are capable of presenting tumor-associated antigens (TAA) for induction and elicitation of tumor-..
  54. CHARACTERIZATION AND CULTURE OF HUMAN LANGERHANS CELLS
    Vera Morhenn; Fiscal Year: 1991
    b>Langerhans cells (LC) are bone marrow-derived, immunocompetent cells which comprise 2-6% of the human epidermal cell population...
  55. Interaction of HIV with Macaque Genital Tract
    ANN M CARIAS; Fiscal Year: 2012
    ..Although mucosal T cells and Langerhans cells have been identified as potential early targets of infection in the female genital tract how the virus gains ..
  56. IMMUNOTOXICOLOGY OF PHENOLS ON EPIDERMAL IMMUNE CELLS
    James Nordlund; Fiscal Year: 1990
    ..e., increase or decrease their number depending on the dose of PSP applied. Langerhans cells (LC) are immune macrophages in the epidermis...
  57. T CELL ACTIVIATION BY DISTINCT ANTIGEN PRESENTING CELLS
    Seth Stevens; Fiscal Year: 2002
    Exposure of humans and experimental animals to ultraviolet irradiation (UV) can lead to immunologic tolerance. Langerhans cells (LC) are the predominant antigen presenting cell (APC) of normal unirradiated epidermis...
  58. T CELL DEPENDENT TERMINAL MATURATION OF LANGERHANS CELLS
    Akira Takashima; Fiscal Year: 2005
    As a member of the dendritic cell (DC) family, Langerhans cells (LC) play key roles in the induction of T cell-mediated immune responses in skin...
  59. Transcutaneous Immunization for an Anthrax Vaccine
    Richard Kenney; Fiscal Year: 2003
    ..takes advantage of the abundance and accessibility of a potent type of antigen presenting cell (APC), called Langerhans cells (LC), located throughout the superficial layer of the skin, the epidermis...
  60. HYALURONAN BINDING PEPTIDE INHIBITORS OF LANGERHANS CELL
    Mark Mummert; Fiscal Year: 2001
    b>Langerhans cells (LC) play essential roles in the induction of cellular immune responses to a variety of skin-relevant antigens...
  61. Cutaneous Gene Therapy with Ultrasound: DNA Vaccination
    Samir Mitragotri; Fiscal Year: 2006
    ..Furthermore, skin offers a natural target site for the delivery of genetic vaccines due to the presence of Langerhans cells that play a critical role in inducing an immune response. However, delivery of DNA to skin is a challenge...
  62. Cytokine Expression in LCH and Therapeutic Response
    Kenneth McClain; Fiscal Year: 2007
    ..There is very little published data on the biology of Langerhans cells (LHC) that has been correlated with clinical presentation, response to therapy, or occurrence of late effects...
  63. Langerhans cell-mediated immune modulation of HPV8 expression and tumorgenesis
    Janet Brandsma; Fiscal Year: 2009
    ..The hypothesis of this proposal is that Langerhans cells (LCs) govern HPV persistence and associated malignant progression...
  64. MACROPHAGE RECEPTORS FOR LEISHMANIA
    David Mosser; Fiscal Year: 2002
    ..The two components of host defense that we will study are the complement system and the epidermal Langerhans cells. These two components are involved very early in the initiation of Leishmania infection and consequently are ..
  65. Alemtuzumab treatment of steroid-refractory acute GvHD
    James Young; Fiscal Year: 2005
    ..Monocyte-derived DCs (moDCs) express CD52, whereas Langerhans cells (LCs) and dermalinterstitial DCs (DDC-IDCs) never express this epitope, either as resident populations in ..