dendritic cells

Summary

Summary: Immunocompetent cells of the lymphoid and hemopoietic systems and SKIN, and possessing branching morphology. They function morphologically and phenotypically by processing ANTIGENS or presenting them to T-CELLS, thereby stimulating cellular immunity (IMMUNITY, CELLULAR). When found in the skin they are called LANGERHANS CELLS; when found in the lymph nodes, they are called interdigitating cells.

Top Publications

  1. ncbi Monocyte and macrophage heterogeneity
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 5:953-64. 2005
  2. pmc Development of monocytes, macrophages, and dendritic cells
    Frederic Geissmann
    Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King s College London, Great Maze Pond, London SE1 1UL, UK
    Science 327:656-61. 2010
  3. pmc SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
    Nadine Laguette
    Institut de Genetique Humaine, Laboratoire de Virologie Moleculaire, CNRS UPR1142, Montpellier 34000, France
    Nature 474:654-7. 2011
  4. pmc Deciphering the transcriptional network of the dendritic cell lineage
    Jennifer C Miller
    Immunology Institute, Mount Sinai School of Medicine, New York, New York, USA
    Nat Immunol 13:888-99. 2012
  5. ncbi Interleukin-10 and the interleukin-10 receptor
    K W Moore
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    Annu Rev Immunol 19:683-765. 2001
  6. ncbi A Toll-like receptor recognizes bacterial DNA
    H Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Suita
    Nature 408:740-5. 2000
  7. ncbi Blood monocytes consist of two principal subsets with distinct migratory properties
    Frederic Geissmann
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Immunity 19:71-82. 2003
  8. pmc Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells
    Muzlifah Haniffa
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Immunity 37:60-73. 2012
  9. ncbi Nomenclature of monocytes and dendritic cells in blood
    Loems Ziegler-Heitbrock
    Helmholtz Zentrum Munchen, Gauting, Germany
    Blood 116:e74-80. 2010
  10. ncbi Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    Tyler J Curiel
    Tulane University Health Science Center, New Orleans, Louisiana 70112, USA
    Nat Med 10:942-9. 2004

Detail Information

Publications361 found, 100 shown here

  1. ncbi Monocyte and macrophage heterogeneity
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 5:953-64. 2005
    ..These advances in our understanding have implications for the development of therapeutic strategies that are targeted to modify particular subpopulations of monocytes...
  2. pmc Development of monocytes, macrophages, and dendritic cells
    Frederic Geissmann
    Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King s College London, Great Maze Pond, London SE1 1UL, UK
    Science 327:656-61. 2010
    ..b>Dendritic cells initiate and regulate the highly pathogen-specific adaptive immune responses and are central to the ..
  3. pmc SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
    Nadine Laguette
    Institut de Genetique Humaine, Laboratoire de Virologie Moleculaire, CNRS UPR1142, Montpellier 34000, France
    Nature 474:654-7. 2011
    ..Finally, silencing of SAMHD1 markedly increases the susceptibility of monocytic-derived dendritic cells to infection...
  4. pmc Deciphering the transcriptional network of the dendritic cell lineage
    Jennifer C Miller
    Immunology Institute, Mount Sinai School of Medicine, New York, New York, USA
    Nat Immunol 13:888-99. 2012
    Although much progress has been made in the understanding of the ontogeny and function of dendritic cells (DCs), the transcriptional regulation of the lineage commitment and functional specialization of DCs in vivo remains poorly ..
  5. ncbi Interleukin-10 and the interleukin-10 receptor
    K W Moore
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    Annu Rev Immunol 19:683-765. 2001
    ..growth and/or differentiation of B cells, NK cells, cytotoxic and helper T cells, mast cells, granulocytes, dendritic cells, keratinocytes, and endothelial cells...
  6. ncbi A Toll-like receptor recognizes bacterial DNA
    H Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Suita
    Nature 408:740-5. 2000
    ..including proliferation of splenocytes, inflammatory cytokine production from macrophages and maturation of dendritic cells. TLR9-/- mice showed resistance to the lethal effect of CpG DNA without any elevation of serum pro-..
  7. ncbi Blood monocytes consist of two principal subsets with distinct migratory properties
    Frederic Geissmann
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Immunity 19:71-82. 2003
    ..Both subsets have the potential to differentiate into dendritic cells in vivo...
  8. pmc Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells
    Muzlifah Haniffa
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Immunity 37:60-73. 2012
    ..These studies inform the rational design of targeted immunotherapies and facilitate translation of mouse functional DC biology to the human setting...
  9. ncbi Nomenclature of monocytes and dendritic cells in blood
    Loems Ziegler-Heitbrock
    Helmholtz Zentrum Munchen, Gauting, Germany
    Blood 116:e74-80. 2010
    ..cells and defines 3 types of monocytes (classical, intermediate, and nonclassical monocytes) and 3 types of dendritic cells (plasmacytoid and 2 types of myeloid dendritic cells) in human and in mouse blood...
  10. ncbi Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    Tyler J Curiel
    Tulane University Health Science Center, New Orleans, Louisiana 70112, USA
    Nat Med 10:942-9. 2004
    ..This specific recruitment of T(reg) cells represents a mechanism by which tumors may foster immune privilege. Thus, blocking T(reg) cell migration or function may help to defeat human cancer...
  11. ncbi CTLA-4 control over Foxp3+ regulatory T cell function
    Kajsa Wing
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Science 322:271-5. 2008
    ..suppressive function of Tregs-in particular, Treg-mediated down-regulation of CD80 and CD86 expression on dendritic cells. Thus, natural Tregs may critically require CTLA-4 to suppress immune responses by affecting the potency of ..
  12. ncbi Immunobiology of dendritic cells
    J Banchereau
    Baylor Institute for Immunology Research, Dallas, Texas 75204, USA
    Annu Rev Immunol 18:767-811. 2000
    b>Dendritic cells (DCs) are antigen-presenting cells with a unique ability to induce primary immune responses. DCs capture and transfer information from the outside world to the cells of the adaptive immune system...
  13. ncbi IRF-7 is the master regulator of type-I interferon-dependent immune responses
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:772-7. 2005
    ..be triggered in many cell types by cytosolic detection of viral infection, or in differentiated plasmacytoid dendritic cells by the Toll-like receptor 9 (TLR9) subfamily, which generates signals via the adaptor MyD88 to elicit robust ..
  14. ncbi Taking dendritic cells into medicine
    Ralph M Steinman
    The Rockefeller University, New York 10065, USA
    Nature 449:419-26. 2007
    b>Dendritic cells (DCs) orchestrate a repertoire of immune responses that bring about resistance to infection and silencing or tolerance to self...
  15. pmc Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes
    Angela Montecalvo
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, PA, USA
    Blood 119:756-66. 2012
    b>Dendritic cells (DCs) are the most potent APCs. Whereas immature DCs down-regulate T-cell responses to induce/maintain immunologic tolerance, mature DCs promote immunity...
  16. ncbi Cross-presentation by dendritic cells
    Olivier P Joffre
    INSERM U932, 26 Rue d Ulm, 75005 Paris, France
    Nat Rev Immunol 12:557-69. 2012
    ..Finally, we review current strategies to use cross-presentation for immunotherapy...
  17. ncbi Innate immune recognition of viral infection
    Taro Kawai
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Suita, Osaka 565 0871, Japan
    Nat Immunol 7:131-7. 2006
    ..These two classes of pattern-recognition receptor molecules are expressed in different intracellular compartments and induce type I interferon responses via distinct signaling pathways...
  18. ncbi Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    Jeong M Kim
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 8:191-7. 2007
    ..We suggest that self-reactive T cells are continuously suppressed by T(reg) cells and that when suppression is relieved, self-reactive T cells become activated and facilitate accelerated maturation of dendritic cells.
  19. ncbi Tolerogenic dendritic cells
    Ralph M Steinman
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021 6399, USA
    Annu Rev Immunol 21:685-711. 2003
    b>Dendritic cells (DCs) have several functions in innate and adaptive immunity...
  20. ncbi An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    Sarkis K Mazmanian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 122:107-18. 2005
    ..A PSA mutant of B. fragilis does not restore these immunologic functions. PSA presented by intestinal dendritic cells activates CD4+ T cells and elicits appropriate cytokine production...
  21. ncbi Human inflammatory dendritic cells induce Th17 cell differentiation
    Elodie Segura
    INSERM U932, 26 Rue d Ulm, 75005 Paris, France
    Immunity 38:336-48. 2013
    b>Dendritic cells (DCs) are critical regulators of immune responses. Under noninflammatory conditions, several human DC subsets have been identified. Little is known, however, about the human DC compartment under inflammatory conditions...
  22. ncbi The biology of NKT cells
    Albert Bendelac
    Howard Hughes Medical Institute, Committee on Immunology, Department of Pathology University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Immunol 25:297-336. 2007
    ..Through reciprocal activation of NKT cells and dendritic cells, synthetic NKT ligands constitute promising new vaccine adjuvants...
  23. ncbi Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    Daniel Mucida
    La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Science 317:256-60. 2007
    ..These findings indicate that a common metabolite can regulate the balance between pro- and anti-inflammatory immunity...
  24. pmc Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
    F Sallusto
    Basel Institute for Immunology, Switzerland
    J Exp Med 179:1109-18. 1994
    ..mononuclear cells that maintain the antigen capturing and processing capacity characteristic of immature dendritic cells in vivo...
  25. pmc Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity
    Marlene Dreux
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell Host Microbe 12:558-70. 2012
    ..viral RNA-, TLR7-, and cell-contact-dependent compensatory interferon response in nonpermissive plasmacytoid dendritic cells (pDCs)...
  26. ncbi Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
    Michel Gilliet
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Rev Immunol 8:594-606. 2008
    Plasmacytoid dendritic cells (pDCs) are important mediators of antiviral immunity through their ability to produce large amounts of type I interferons (IFNs) on viral infection...
  27. pmc The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting
    Miriam Merad
    Department of Oncological Sciences, Mount Sinai Medical School, New York, NY 10029, USA
    Annu Rev Immunol 31:563-604. 2013
    b>Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune responses according to peripheral cues...
  28. ncbi Retinoic acid imprints gut-homing specificity on T cells
    Makoto Iwata
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194 8511, Japan
    Immunity 21:527-38. 2004
    ..alpha4beta7 and the chemokine receptor CCR9 is essential and is induced by antigenic stimulation with dendritic cells from the gut-associated lymphoid organs...
  29. ncbi Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?
    Maria A Curotto de Lafaille
    Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, and Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Immunity 30:626-35. 2009
    ....
  30. pmc A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    Janine L Coombes
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    J Exp Med 204:1757-64. 2007
    ..Moreover, we identify a population of CD103(+) mesenteric lymph node dendritic cells (DCs) that induce the development of Foxp3(+) T reg cells...
  31. pmc How regulatory T cells work
    Dario A A Vignali
    Department of Immunology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105 2794, USA
    Nat Rev Immunol 8:523-32. 2008
    ..In addition, we propose the hypothesis that effector T cells may not be 'innocent' parties in this suppressive process and might in fact potentiate T(Reg)-cell function...
  32. pmc Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses
    Ido Amit
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Science 326:257-63. 2009
    ..this approach to derive regulatory networks that control the transcriptional response of mouse primary dendritic cells to pathogens...
  33. pmc A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells
    Nicolas Manel
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 467:214-7. 2010
    b>Dendritic cells serve a key function in host defence, linking innate detection of microbes to activation of pathogen-specific adaptive immune responses...
  34. ncbi CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis
    Samira Tamoutounour
    Centre d immunologie de Marseille Luminy, Aix Marseille Universite, Marseille, France
    Eur J Immunol 42:3150-66. 2012
    b>Dendritic cells (DCs) and monocyte-derived macrophages (MΦs) are key components of intestinal immunity. However, the lack of surface markers differentiating MΦs from DCs has hampered understanding of their respective functions...
  35. pmc GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells
    Melanie Greter
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunity 36:1031-46. 2012
    GM-CSF (Csf-2) is a critical cytokine for the in vitro generation of dendritic cells (DCs) and is thought to control the development of inflammatory DCs and resident CD103(+) DCs in some tissues...
  36. ncbi T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    Thorsten R Mempel
    The CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 427:154-9. 2004
    ..T-cell responses in lymph nodes (LNs) require contact-dependent information exchange between T cells and dendritic cells (DCs)...
  37. ncbi Transforming growth factor-beta regulation of immune responses
    Ming O Li
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Immunol 24:99-146. 2006
    ..through the regulation of chemotaxis, activation, and survival of lymphocytes, natural killer cells, dendritic cells, macrophages, mast cells, and granulocytes...
  38. ncbi Autophagy-dependent viral recognition by plasmacytoid dendritic cells
    Heung Kyu Lee
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
    Science 315:1398-401. 2007
    Plasmacytoid dendritic cells (pDCs) detect viruses in the acidified endosomes by means of Toll-like receptors (TLRs). Yet, pDC responses to certain single-stranded RNA (ssRNA) viruses occur only after live viral infection...
  39. pmc Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
    D Hawiger
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 194:769-79. 2001
    b>Dendritic cells (DCs) have the capacity to initiate immune responses, but it has been postulated that they may also be involved in inducing peripheral tolerance...
  40. ncbi Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen
    Maud Plantinga
    Laboratory of Immunoregulation and Mucosal Immunology, Department for Molecular Biomedical Research, VIB, Ghent 9050, Belgium
    Immunity 38:322-35. 2013
    b>Dendritic cells (DCs) are crucial for mounting allergic airway inflammation, but it is unclear which subset of DCs performs this task...
  41. pmc Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon
    Aymeric Rivollier
    Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 209:139-55. 2012
    b>Dendritic cells (DCs) and macrophages (MPs) are important for immunological homeostasis in the colon. We found that F4/80(hi)CX3CR1(hi) (CD11b(+)CD103(-)) cells account for 80% of mouse colonic lamina propria MHC-II(hi) cells...
  42. ncbi Decisions about dendritic cells: past, present, and future
    Ralph M Steinman
    Laboratory of Cell Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    Annu Rev Immunol 30:1-22. 2012
    ..b>Dendritic cells are required to explain how this remarkable system is energized and directed...
  43. ncbi CpG motifs in bacterial DNA and their immune effects
    Arthur M Krieg
    Department of Veterans Affairs Medical Center, Iowa City, Iowa 52246, USA
    Annu Rev Immunol 20:709-60. 2002
    ..Cells that express TLR-9, which include plasmacytoid dendritic cells (PDCs) and B cells, produce Th1-like proinflammatory cytokines, interferons, and chemokines...
  44. ncbi Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
    Jane Tian
    Inflammation and Autoimmune Group, Research Department, MedImmune, Gaithersburg, Maryland 20878, USA
    Nat Immunol 8:487-96. 2007
    ..Stimulation of Toll-like receptor 9 (TLR9) by DNA is important in the activation of plasmacytoid dendritic cells and B cells...
  45. ncbi CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
    R Forster
    Molecular Tumorgenetics and Immunogenetics, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Cell 99:23-33. 1999
    ..Upon activation, mature skin dendritic cells fail to migrate into the draining lymph nodes...
  46. pmc Cancer immunotherapy via dendritic cells
    Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak Avenue, Dallas, Texas 75204, USA
    Nat Rev Cancer 12:265-77. 2012
    ..Owing to their properties, dendritic cells (DCs) are often called 'nature's adjuvants' and thus have become the natural agents for antigen delivery...
  47. ncbi Toll-like receptor control of the adaptive immune responses
    Akiko Iwasaki
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
    Nat Immunol 5:987-95. 2004
    ..Recent studies have provided important clues about the mechanisms of TLR-mediated control of adaptive immunity orchestrated by dendritic cell populations in distinct anatomical locations...
  48. pmc Luminal bacteria recruit CD103+ dendritic cells into the intestinal epithelium to sample bacterial antigens for presentation
    Julia Farache
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Immunity 38:581-95. 2013
    CD103+ dendritic cells (DCs) carry bacteria from the small intestine and can present antigens to T cells. Yet they have not been recorded sampling luminal bacteria or presenting bacterial antigens in mesentery lymph nodes...
  49. pmc DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells
    Boonrat Tassaneetrithep
    Division of Retrovirology, Walter Reed Army Institite of Research and Henry M Jackson Foundation for the Advancement of Military Medicine Diseases, Rockville, MD 20850, USA
    J Exp Med 197:823-9. 2003
    Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation...
  50. ncbi Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors
    Francois Ghiringhelli
    Institut National de la Sante et de la Recherche Medicale, U805, Villejuif, France
    Nat Med 15:1170-8. 2009
    The therapeutic efficacy of anticancer chemotherapies may depend on dendritic cells (DCs), which present antigens from dying cancer cells to prime tumor-specific interferon-gamma (IFN-gamma)-producing T lymphocytes...
  51. pmc In vivo analysis of dendritic cell development and homeostasis
    Kang Liu
    Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA
    Science 324:392-7. 2009
    b>Dendritic cells (DCs) in lymphoid tissue arise from precursors that also produce monocytes and plasmacytoid DCs (pDCs)...
  52. pmc Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas
    Cheolho Cheong
    Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    Cell 143:416-29. 2010
    b>Dendritic cells (DCs), critical antigen-presenting cells for immune control, normally derive from bone marrow precursors distinct from monocytes...
  53. pmc Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
    Sarah L Jongbloed
    Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia
    J Exp Med 207:1247-60. 2010
    ..The data demonstrate a role for CD141+ DCs in the induction of cytotoxic T lymphocyte responses and suggest that they may be the most relevant targets for vaccination against cancers, viruses, and other pathogens...
  54. ncbi IDO expression by dendritic cells: tolerance and tryptophan catabolism
    Andrew L Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    Nat Rev Immunol 4:762-74. 2004
    ..In this review, we summarize key recent developments and propose a unifying model for the role of IDO in tolerance induction...
  55. pmc Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells
    Natasa Obermajer
    Department of Surgery, University of Pittsburgh, Hillman Cancer Center, UPCI Research Pavilion, 5117 Center Ave, Pittsburgh, PA 15213 1863, USA
    Blood 118:5498-505. 2011
    b>Dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) show opposing roles in the immune system...
  56. ncbi Rapid leukocyte migration by integrin-independent flowing and squeezing
    Tim Lämmermann
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Nature 453:51-5. 2008
    ..Myosin II-dependent contraction is only required on passage through narrow gaps, where a squeezing contraction of the trailing edge propels the rigid nucleus...
  57. ncbi Molecular identification of a danger signal that alerts the immune system to dying cells
    Yan Shi
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Nature 425:516-21. 2003
    ..Danger signals are thought to act by stimulating dendritic cells to mature so that they can present foreign antigens and stimulate T lymphocytes...
  58. ncbi Signalling through C-type lectin receptors: shaping immune responses
    Teunis B H Geijtenbeek
    Academic Medical Center, University of Amsterdam, The Netherlands
    Nat Rev Immunol 9:465-79. 2009
    C-type lectin receptors (CLRs) expressed by dendritic cells are crucial for tailoring immune responses to pathogens...
  59. pmc Origin of the lamina propria dendritic cell network
    Milena Bogunovic
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Immunity 31:513-25. 2009
    CX(3)CR1(+) and CD103(+) dendritic cells (DCs) in intestinal lamina propria play a key role in mucosal immunity. However, the origin and the developmental pathways that regulate their differentiation in the lamina propria remain unclear...
  60. ncbi SOCS proteins, cytokine signalling and immune regulation
    Akihiko Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Nat Rev Immunol 7:454-65. 2007
    ..In this Review we bring together data from recent studies on SOCS proteins and their role in immunity, and propose a cohesive model of how cytokine signalling regulates immune-cell function...
  61. pmc MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells
    Maurizio Ceppi
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    Proc Natl Acad Sci U S A 106:2735-40. 2009
    In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation (maturation) that exhibits specific mechanisms to control immunity...
  62. ncbi CCR7 and its ligands: balancing immunity and tolerance
    Reinhold Forster
    Institute of Immunology, Hannover Medical School 30625 Hannover, Germany
    Nat Rev Immunol 8:362-71. 2008
    ..via high endothelial venules, as well as steady state and inflammation-induced lymph-node-bound migration of dendritic cells via afferent lymphatics...
  63. ncbi Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Immunity 17:375-87. 2002
    ..Our findings indicate that IL-17 plays an important role in activating T cells in allergen-specific T cell-mediated immune responses...
  64. pmc Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity
    Kai Hildner
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Science 322:1097-100. 2008
    Although in vitro observations suggest that cross-presentation of antigens is mediated primarily by CD8alpha+ dendritic cells, in vivo analysis has been hampered by the lack of systems that selectively eliminate this cell lineage...
  65. pmc The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
    Zhiqiang Zhang
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 12:959-65. 2011
    ..identification of DDX41, a member of the DEXDc family of helicases, as an intracellular DNA sensor in myeloid dendritic cells (mDCs)...
  66. pmc Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    Cheng Ming Sun
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:1775-85. 2007
    ..b>Dendritic cells (DCs) purified from the lamina propria (Lp; LpDCs) of the small intestine were found to promote a high level ..
  67. ncbi Immunosuppressive networks in the tumour environment and their therapeutic relevance
    Weiping Zou
    Tulane University Health Sciences Center, Section of Hematology and Medical Oncology, 1430 Tulane Avenue, New Orleans, Louisiana 70112 2699, USA
    Nat Rev Cancer 5:263-74. 2005
    ..Why then has tumour immunotherapy resulted in a generally poor clinical efficiency? The reason might lie in the increasingly documented fact that tumours develop diverse strategies that escape tumour-specific immunity...
  68. pmc Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria
    Frank A W Verreck
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Albinusdreef 2, NL 2333 ZA, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 101:4560-5. 2004
    ..Activated dendritic cells produced both IL-12 and IL-23, but unlike Mphi-1 they slightly reduced their IL-23 secretion after addition ..
  69. pmc Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance
    Laura Bonifaz
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 196:1627-38. 2002
    To identify endocytic receptors that allow dendritic cells (DCs) to capture and present antigens on major histocompatibility complex (MHC) class I products in vivo, we evaluated DEC-205, which is abundant on DCs in lymphoid tissues...
  70. ncbi TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Immunity 19:59-70. 2003
    b>Dendritic cells (DCs) present microbial antigens to T cells and provide inflammatory signals that modulate T cell differentiation...
  71. ncbi Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    Veit Hornung
    Department of Internal Medicine, Division of Clinical Pharmacology, University of Munich, Munich, Germany
    J Immunol 168:4531-7. 2002
    ..TLR10 was highly expressed in B cells and weakly expressed in plasmacytoid dendritic cells (PDC). High expression of TLR2 was characteristic for monocytes...
  72. ncbi A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
    D M Anderson
    Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA
    Nature 390:175-9. 1997
    b>Dendritic cells are rare haematopoietic cells that reside in a number of organs and tissues...
  73. pmc Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells
    Giorgio Napolitani
    Institute for Research in Biomedicine, Oncology Institute of Southern Switzerland, CH 6500, Bellinzona, Switzerland
    Nat Immunol 6:769-76. 2005
    Toll-like receptors (TLRs) sense microbial products and initiate adaptive immune responses by activating dendritic cells (DCs)...
  74. ncbi Mouse and human dendritic cell subtypes
    Ken Shortman
    Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
    Nat Rev Immunol 2:151-61. 2002
    b>Dendritic cells (DCs) collect and process antigens for presentation to T cells, but there are many variations on this basic theme...
  75. ncbi A chemokine-driven positive feedback loop organizes lymphoid follicles
    K M Ansel
    Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    Nature 406:309-14. 2000
    ..Here we show that lymph nodes contain two types of B-cell-rich compartment: follicles containing follicular dendritic cells, and areas lacking such cells...
  76. ncbi CTLA-4-Ig regulates tryptophan catabolism in vivo
    Ursula Grohmann
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nat Immunol 3:1097-101. 2002
    ..In vitro, we show that CTLA-4-Ig regulates cytokine-dependent tryptophan catabolism in B7-expressing dendritic cells. These data suggest that modulation of tryptophan catabolism is a means by which CTLA-4 functions in vivo and ..
  77. pmc Immunosuppressive strategies that are mediated by tumor cells
    Gabriel A Rabinovich
    Division of Immunogenetics, Hospital de Clinicas Jose de San Martin, University of Buenos Aires, Buenos Aires, Argentina
    Annu Rev Immunol 25:267-96. 2007
    ..these include regulatory T cells, natural killer T cells, and distinct subsets of immature and mature dendritic cells. The current wealth of preclinical information promises a future scenario in which the synchronized blockade ..
  78. ncbi An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
    M B Lutz
    Department of Dermatology, University of Erlangen, Germany
    J Immunol Methods 223:77-92. 1999
    As dendritic cells (DC) are rare populations in all organs, their generation from hematopoietic precursors in large quantities has proven critical to study their biology...
  79. pmc The origin and development of nonlymphoid tissue CD103+ DCs
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 206:3115-30. 2009
    CD103(+) dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the mechanisms that regulate the development of these cells...
  80. ncbi DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
    Mikhail B Litinskiy
    Division of Molecular Immunology, Department of Pathology and Laboratory Medicine, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Nat Immunol 3:822-9. 2002
    ..We show here that dendritic cells up-regulate BLyS and APRIL upon exposure to interferon-alpha, interferon-gamma or CD40 ligand...
  81. pmc The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues
    Claudia Waskow
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065, USA
    Nat Immunol 9:676-83. 2008
    ..In contrast, Flt3 was essential to the regulation of homeostatic DC development in the spleen, where it was needed to maintain normal numbers of DCs by controlling their division in the periphery...
  82. pmc Plasmacytoid dendritic cells: recent progress and open questions
    Boris Reizis
    Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York 10032, USA
    Annu Rev Immunol 29:163-83. 2011
    Plasmacytoid dendritic cells (pDCs) are specialized in rapid and massive secretion of type I interferon (IFN-α/β) in response to foreign nucleic acids...
  83. pmc Induction of CD8+ T-cell responses against novel glioma-associated antigen peptides and clinical activity by vaccinations with {alpha}-type 1 polarized dendritic cells and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in
    Hideho Okada
    G12 a Research Pavilion at the Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, PA 15213 1863, USA
    J Clin Oncol 29:330-6. 2011
    ..trial was performed to evaluate the safety and immunogenicity of a novel vaccination with α-type 1 polarized dendritic cells (αDC1) loaded with synthetic peptides for glioma-associated antigen (GAA) epitopes and administration of ..
  84. pmc CD11c depletion severely disrupts Th2 induction and development in vivo
    Alexander T Phythian-Adams
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, EH9 3JT Scotland, UK
    J Exp Med 207:2089-96. 2010
    Although dendritic cells (DCs) are adept initiators of CD4(+) T cell responses, their fundamental importance in this regard in Th2 settings remains to be demonstrated...
  85. ncbi IL-10-generated tolerogenic dendritic cells are optimal for functional regulatory T cell induction--a comparative study of human clinical-applicable DC
    Martine A Boks
    Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Clin Immunol 142:332-42. 2012
    Tolerogenic dendritic cells (tDC) are a promising tool for specific cellular therapy to induce immunological tolerance in transplantation and autoimmunity...
  86. pmc Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine
    Santhakumar Manicassamy
    Emory Vaccine Center, and Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA
    Science 329:849-53. 2010
    b>Dendritic cells (DCs) play a vital role in initiating robust immunity against pathogens as well as maintaining immunological tolerance to self antigens...
  87. ncbi Differential antigen processing by dendritic cell subsets in vivo
    Diana Dudziak
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    Science 315:107-11. 2007
    b>Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity...
  88. ncbi NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
    Rachel Cooney
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Headington, Oxford, UK
    Nat Med 16:90-7. 2010
    Nucleotide-binding oligomerization domain-containing-2 (NOD2) acts as a bacterial sensor in dendritic cells (DCs), but it is not clear how bacterial recognition links with antigen presentation after NOD2 stimulation...
  89. ncbi Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells
    Xiao Xia Jiang
    Department of Cell Biology, Institute of Basic Medical Sciences, Tai Ping Road 27, Beijing 100850, PR China
    Blood 105:4120-6. 2005
    ..investigation, we addressed the effects of human MSCs on the differentiation, maturation, and function of dendritic cells (DCs) derived from CD14+ monocytes in vitro...
  90. pmc Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells
    Annabell Bachem
    Molecular Immunology, Robert Koch Institute, 13353 Berlin, Germany
    J Exp Med 207:1273-81. 2010
    In recent years, human dendritic cells (DCs) could be subdivided into CD304+ plasmacytoid DCs (pDCs) and conventional DCs (cDCs), the latter encompassing the CD1c+, CD16+, and CD141+ DC subsets...
  91. pmc How tolerogenic dendritic cells induce regulatory T cells
    Roberto A Maldonado
    Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    Adv Immunol 108:111-65. 2010
    Since their discovery by Steinman and Cohn in 1973, dendritic cells (DCs) have become increasingly recognized for their crucial role as regulators of innate and adaptive immunity...
  92. pmc Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells
    M V Dhodapkar
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021, USA
    J Exp Med 193:233-8. 2001
    Immunostimulatory properties of dendritic cells (DCs) are linked to their maturation state. Injection of mature DCs rapidly enhances antigen-specific CD4+ and CD8+ T cell immunity in humans...
  93. pmc Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4
    Christian Termeer
    Department of Dermatology, University of Freiburg, Freiburg D 79104, Germany
    J Exp Med 195:99-111. 2002
    ..sHA) produced during inflammation have been shown to be potent activators of immunocompetent cells such as dendritic cells (DCs) and macrophages...
  94. pmc The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor
    Sarah E Ewald
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, 405 Life Sciences Addition, Berkeley, California 94720 3200, USA
    Nature 456:658-62. 2008
    ..by which TLR9 and TLR7 exit the endoplasmic reticulum and travel to endolysosomes in mouse macrophages and dendritic cells. The ectodomains of TLR9 and TLR7 are cleaved in the endolysosome, such that no full-length protein is ..
  95. ncbi Dendritic cell subsets in primary and secondary T cell responses at body surfaces
    William R Heath
    The Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    Nat Immunol 10:1237-44. 2009
    We examine the role of dendritic cells subsets in immunity to peripheral infections, with emphasis on the differences in the regulation of primary and secondary T cell responses to viruses...
  96. pmc Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients
    Nick Giannoukakis
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Diabetes Care 34:2026-32. 2011
    The safety of dendritic cells to selectively suppress autoimmunity, especially in type 1 diabetes, has never been ascertained...
  97. ncbi Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
    M Rescigno
    Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milano, Italy
    Nat Immunol 2:361-7. 2001
    ..We report here a new mechanism for bacterial uptake in the mucosa tissues that is mediated by dendritic cells (DCs)...
  98. ncbi Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells
    Sammy Bedoui
    The Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    Nat Immunol 10:488-95. 2009
    Skin-derived dendritic cells (DCs) include Langerhans cells, classical dermal DCs and a langerin-positive CD103(+) dermal subset. We examined their involvement in the presentation of skin-associated viral and self antigens...
  99. ncbi Development and functional specialization of CD103+ dendritic cells
    Maria Luisa del Rio
    Institute of Immunology, Hannover Medical School, Hannover, Germany
    Immunol Rev 234:268-81. 2010
    CD103 (alpha(E)) integrin expression distinguishes a population of dendritic cells (DCs) that can be found in many if not all lymphoid and non-lymphoid organs. CD103(+) DCs display distinct functional activities...
  100. ncbi A blast from the past: clearance of apoptotic cells regulates immune responses
    John Savill
    MRC University of Edinburgh Centre for Inflammation Research, Department of Clinical and Surgical Sciences Internal Medicine, Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, UK
    Nat Rev Immunol 2:965-75. 2002
    ..However, the binding and ingestion of dying cells by monocytes/macrophages and dendritic cells can also influence immune responses markedly by enhancing or suppressing inflammation...
  101. ncbi Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells
    I D Iliev
    Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy
    Gut 58:1481-9. 2009
    In mice, a subpopulation of gut dendritic cells (DCs) expressing CD103 drives the development of regulatory T (T(reg)) cells...

Research Grants121 found, 100 shown here

  1. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
    ..Inflammatory cell invasion is characterized by invading adventitial and medial dendritic cells, macrophage, T lymphocytes, specifically T helper 1 (TH1) subpopulations, and giant cells, with attendant ..
  2. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2012
    ..For long-term protection, the biomaterial will transfect antigen-presenting cells (specifically dendritic cells - DCs) to produce T- and B-cell memory and antibody expression, and potentially stimulate direct native ..
  3. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..of U87 cells and test whether chemerin or post-culture media from GBM cells will recruit plasmacytoid dendritic cells. Our long-term goal is to understand the roles of thrombin and carboxypeptidase B and their cleavage products ..
  4. Targeting Galectin-3 with novel drugs for treatment of eczema
    Fu Tong Liu; Fiscal Year: 2010
    ..eczema is a complex disease, involving multiple immunologic and inflammatory pathways that include T cells, dendritic cells, mast cells and eosinophils, as well as keratinocytes...
  5. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..The goal of this project is to develop methods to introduce the IL-10 gene ex vivo into donor dendritic cells (DCs) reside within transplant tissues...
  6. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
    ..They migrate throughout the body for surveillance, and interact with T cells and dendritic cells within lymphoid tissue for antigen presentation...
  7. Tat and CDK9 on gene expression alterations coupled to HIV-1 Associated Dementia
    Xavier Grana; Fiscal Year: 2010
    ..Importantly, Tat inhibits cyclin T1/CDK9-dependent gene expression of certain genes in macrophages, dendritic cells and B cells via a competition mechanism with specific transcriptional activators...
  8. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    ..DVs infect peripheral human leukocytes, dendritic cells and endothelial cells, and mechanisms by which DVs enhance vascular permeability are just beginning to be ..
  9. Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
    Insoo Kang; Fiscal Year: 2010
    ..For instance, vitamin D3 (VD3) can affect the functions of immune cells including macrophages, dendritic cells (DC), B and T cells...
  10. Regulation of Type 1 Interferon Production by Autoimmunity-Associated PTPN22
    Yaya Wang; Fiscal Year: 2013
    ..1, I will determine the role of PTPN22 in TLR signaling by using bone-marrow derived macrophages (BMMs) and dendritic cells (BMDCs) from PTPN22 deficient mice...
  11. C5a as an Anti-HIV Microbicidal Candidate
    PHILIPPE ANDRE GALLAY; Fiscal Year: 2013
    ..microbicidal properties: it i) blocks HIV infection of primary targets including T cells, macrophages and dendritic cells;ii) exhibits a broad range of antiviral activity against primary HIV isolates, multi-drug resistant HIV ..
  12. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..against prevention of these pathogens and consists of numerous soluble factors and cell types, including dendritic cells (DC) and natural killer cells...
  13. Signaling by Cytoplasmic Tyrosine Kinases in Leukocytes
    Clifford A Lowell; Fiscal Year: 2013
    ..Deletion of SHP-1 in dendritic cells (using CD11c-Cre) results in autoimmunity, but no inflammation...
  14. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
    ..invade an underlying decidua comprised of decidual cells and such immune cells as macrophages (MFs) and dendritic cells (DCs)...
  15. Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
    Alexandra L Howell; Fiscal Year: 2013
    ..Macrophages and dendritic cells (DC) in mucosal tissues express receptors that are triggered by viral proteins and nucleic acids, leading to ..
  16. Characterizing TLR Function of Human Dendritic Cells in the Elderly
    Alexander Panda; Fiscal Year: 2012
    ....
  17. Effect of diet & commensal bacteria on diabetes outcome in NOD mouse
    Li Wen; Fiscal Year: 2010
    ..The idea is that these organisms stimulate regulatory T cells by influencing the maturation of dendritic cells and reduce pathogenic effector cells...
  18. Monocyte activation and the role of CD11c in obesity-linked metabolic syndrome
    Huaizhu Wu; Fiscal Year: 2013
    ..CD11c is a b2 integrin primarily expressed on monocytes/macrophages and dendritic cells (DCs) that is a marker for monocyte/macrophage activation and participates in monocyte recruitment...
  19. Regulation of vaccine-induced anti-fungal T17 cells
    MARCEL WUETHRICH; Fiscal Year: 2013
    ..our new Blastomyces-specific TCR Tg mouse, we have established an in vitro screen with bone marrow derived dendritic cells from knockout mice and an in vivo adoptive transfer system to delineate the signaling adaptors, pathogen ..
  20. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010
    ..receptor is found on many essential cells of the host immune response, including T and B cells, macrophages, dendritic cells, PMNs, mast cells, and natural killer cells...
  21. Vitamin A adjuvant to enhance gut immunity and rotavirus vaccines in neonates
    Linda J Saif; Fiscal Year: 2010
    ..Gut dendritic cells (DCs) convert dietary VitA to retinoic acid (RA) and DCs and/or RA in concert with key signaling molecules (..
  22. Impact of Diabetes and Hyperlipidemia on Host Defense
    Hardy Kornfeld; Fiscal Year: 2013
    ..Our data suggest the hypothesis that DM impairs a critical early step in TB defense where dendritic cells (DC) are recruited to foci of infected AMF to acquire bacilli and bring them to the TLN to initiate the ..
  23. Colitis Induced by immune responses to luminal bacteria-mouse
    Ryan B Sartor; Fiscal Year: 2012
    ..faecalis affect innate immune responses in dendritic cells and macrophages? 2...
  24. Glycosaminoglycans and Cell Traffic in the Lymphatic Microenvironment
    Mark M Fuster; Fiscal Year: 2012
    ..genetic disruption of lymphatic glycosaminoglycan biosynthesis will alter the ability of tumor as well as dendritic cells to migrate toward lymphatic vasculature and traffic to lymph nodes in a chemokine-dependent manner...
  25. Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
    LAURA ELISE CROTTY ALEXANDER; Fiscal Year: 2013
    ..b>Dendritic cells, eosinophils, and mast cells are known to play a role in the development and progression of asthma, however ..
  26. Engineering the Brain Immune System for Tumor Therapy
    Maria G Castro; Fiscal Year: 2013
    ..e. the blood-brain barrier, a lack of proper antigen presenting cells (i.e., dendritic cells, DCs) in the healthy brain, absence of classical lymphatic outflow channels, and local expression of the ..
  27. Characterization of IL36, a novel cytokine
    Albert Zlotnik; Fiscal Year: 2012
    ..We identified many genes that exhibit strong expression in T, B cells, monocytes, or dendritic cells, including 92 uncharacterized genes that encode either transmembrane or secreted proteins...
  28. Metabolic Crosstalk Between Immune Cells and the Liver in Obesity
    BENJAMIN MANTELL; Fiscal Year: 2012
    ..g. dendritic cells, in the molecular pathogenesis of obesity...
  29. TNF Family Members and Control of Fibrotic Disease
    Michael Croft; Fiscal Year: 2013
    ..a TNF superfamily protein, that can be expressed on a number of cell types including activated T cells, dendritic cells, and inflamed epithelial cells, was responsible for mediating collagen production, smooth muscle hyperplasia, ..
  30. Autoimmunity Center of Excellence - Rochester
    R John Looney; Fiscal Year: 2013
    ..In addition, we have preliminary data that bortezomib can block alpha interferon production by plasmacytoid dendritic cells. However, bortezomib can cause severe neuropathy and is therefore not appropriate non-malignant diseases...
  31. ROLE OF MUC1 IN THE GENESIS OF ALLERGIC ASTHMA
    Kwang Chul Kim; Fiscal Year: 2010
    ..Together with airway epithelial cells and macrophages, lung dendritic cells (LDC) are also key regulators of pulmonary inflammation in response to both inhaled pathogens and allergens...
  32. ANIMAL MODELS OF HYPERTHYROIDISM
    Sandra M McLachlan; Fiscal Year: 2012
    ..3. Induced tolerance to prevent or treat experimental Graves'disease. Dendritic cells (DC) are potent antigen-presenting cells...
  33. Mechanisms for Cardiovascular Effects of air pollutants: Effect of Age and Sex
    BRITT HOLMEN; Fiscal Year: 2010
    ..g. dendritic cells, alveolar macrophages, CD4+ T cells) induced after exposures to engine exhaust, and determine the effects of ..
  34. Gold Nanoparticle Assisted Delivery of Cancer Vaccines and Immune Stimulants
    Adam Lin; Fiscal Year: 2013
    ..However, delivery of vaccine antigen/peptide to dendritic cells (DCs) remains a limiting factor for persistent anti-tumor immune response...
  35. Cellular interactions in asthma
    CHRISTOPHER DAVID CABALLERO ALLEN; Fiscal Year: 2012
    ..cell types of interest will be mast cells, basophils, eosinophils, neutrophils, macrophages, monocytes, dendritic cells, T cells, and B cells...
  36. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2012
    ..tumor cell-derived HSP-peptide complex as tumor antigens for professional antigen presenting cells, such as, dendritic cells, and thereby induce a strong tumor-specific systemic immune response that would augment the efficacy of HIFU ..
  37. REGULATION OF EAE WITH RECOMBINANT TCR LIGANDS
    Arthur A Vandenbark; Fiscal Year: 2013
    ..data showing rapid antigen non-specific RTL binding to antigen-presenting cells (APC), including macrophages, dendritic cells (DC) and B cells, strongly suggest alternative tolerogenic pathways...
  38. TOLLIP and Tuberculosis Immunopathogenesis
    JAVEED ALI SHAH; Fiscal Year: 2013
    ..He studied cellular immunology of T cells and dendritic cells at the NIH as Howard Hughes Research Scholar as well as protein biochemistry as an undergraduate at the ..
  39. 3D Skin Model to Test Toxic and Sensitizing Potentials of Environmental Chemicals
    Akira Takashima; Fiscal Year: 2010
    ..Because several different contact allergens are known to induce IL-1[unreadable] mRNA expression by dendritic cells (DCs) in the skin, we have developed a HTP-compatible DC biosensor clone by engineering our skin-derived DC ..
  40. Galectin-3 in regulation of allergic skin inflammation
    Fu Tong Liu; Fiscal Year: 2013
    ..model suggests that atopic dermatitis is attributable to a Th2-mediated inflammatory response and T cells, dendritic cells, and mast cells play important roles...
  41. IL-22 in Thymic Regeneration
    Marcel R m van den Brink; Fiscal Year: 2013
    ..were increased, b) IL-22 production by thymic ILCs (tILCs) was increased, c) IL-23 production by thymic dendritic cells (tDCs) was increased and could enhance IL-22 production by innate lymphoid cells, and d) IL-22 administration ..
  42. Pathogenesis of Subtype IE Venezuelan Equine Encephalitis Virus
    ALISON PAIGE ADAMS; Fiscal Year: 2012
    ..As early cell targets of VEEV infection, equine macrophages/dendritic cells (DCs) will be tested for their ability to support viral replication...
  43. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad H Chaudry; Fiscal Year: 2010
    ..signaling events, we will characterize signaling alterations in Kupffer cells, alveolar MO, PMO, SMO, splenic dendritic cells (DC) and splenic T cells, peripheral blood monocytes and T cells and correlate those changes with their ..
  44. Virus interference with Toll like Receptor Response on Dendritic Cells
    Elina I Zuniga; Fiscal Year: 2010
    ..It has been well demonstrated that microbial recognition by toll like receptors (TLRs) on dendritic cells (DCs) determines the magnitude of inflammation, limits early pathogen replication and sets the imprinting of ..
  45. Disease-related defects in dendritic cell processing of bacterial antigens
    Michael S Marks; Fiscal Year: 2012
    ..In conventional dendritic cells (DCs), antigens from phagocytosed bacteria - such as Listeria monocytogenes - are processed and presented by ..
  46. Lung and bone marrow crosstalk during a respiratory infection
    CAROLINA B LOPEZ; Fiscal Year: 2010
    ..interferons in the BM could be greatly relevant for the effective development of immunity as pre-treatment of dendritic cells with type I IFN renders them hyperresponsive to virus infection in vitro...
  47. Breakthroughs to advance the in vitro propagation of human noroviruses
    Qiuhong Wang; Fiscal Year: 2010
    ..of porcine SaV;2) Role of innate immunity in inhibiting murine NoV (MNV) infection and evidence for dendritic cells (DCs) and macrophages as in vivo and in vitro MNV targets;3) Histo-blood group antigens as potential ..
  48. Regulation of TSLP receptor expression and function in eczema in mice and man
    Steven F Ziegler; Fiscal Year: 2013
    ..Responsiveness to TSLP is enhanced in AD patients through a process that depends upon the capacity for dendritic cells (DCs) to upregulate TSLP receptor (TSLPR) following ligation of Fc receptors by allergen...
  49. Host defense against poxviruses and viral immune evasion
    Liang Deng; Fiscal Year: 2011
    ..award from NIAID, the Principle Investigator has been focusing on elucidating how poxviruses are sensed in dendritic cells (DCs), macrophages and epithelial cells...
  50. Translational Immunology Research and Accelerated [vaccine] Development (TRIAD)
    ANNE SEARLS DEGROOT; Fiscal Year: 2013
    ..We will optimize payload, delivery, formulation, and adjuvanting by exploring a range of delivery options [Dendritic cells, DEC205, DNA, electroporation, mucosal delivery)...
  51. Define the role of dendritic cells in HTLV-1 associated neuroinflammatory disease
    Pooja Jain; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dendritic cells (DCs) are the most potent antigen presenting cells and are recognized as key regulators of the immune system, linking both stimulatory and inhibitory components of normal immunity...
  52. Modeling distinct neonatal purine metabolism to inform vaccine development
    Ofer Levy; Fiscal Year: 2013
    ..Monocyte (Mo)-derived dendritic cells (MoDCs) are sensitive to Ado inhibition and express cell-associated Ado-generating (CD73) and metabolizing (..
  53. Towards a vaccine against Fasciola hepatica using FhSAP2 as an antigen
    Ana M Espino; Fiscal Year: 2013
    ..the levels of antibody subclasses as well as the activation status of B- and T-cells, macrophages (MX) and dendritic cells (DCs) elicited in naove mice and these parameters will be correlated with the levels of protection obtained ..
  54. Microneedle-based immunization against pandemic influenza
    Mark R Prausnitz; Fiscal Year: 2011
    ..S. mail. Because microneedle patches target delivery to skin's dendritic cells, much lower vaccine doses should be needed, which is vital when pandemic vaccine supplies are limited...
  55. Lipid A &Innate Immune Receptors in Neisseria Infection
    Gary A Jarvis; Fiscal Year: 2013
    ..model of LA bioactivity by determining the potential of the mutant LOS to signal through TLR4, to mature dendritic cells and polarize T cells, to induce microRNA, to bind to the TLR4-MD-2 complex, and to induce differences in ..
  56. Cigarette Smoke-derived Electrophilic Aldehydes and Airway Inflammation
    Albert van Der Vliet; Fiscal Year: 2013
    ..epithelial injury and are likely mediated by altered epithelial barrier integrity and interaction with dendritic cells, the main antigen-presentng cell in the lung, although the mechanisms by which acrolein impacts on epithelial ..
  57. The role of regulatory T cells in biliary atresia
    Alexander Miethke; Fiscal Year: 2013
    ..these changes were linked to down-regulation of B7 costimulatory molecules on hepatic myeloid dendritic cells. Adoptive transfer experiments with CD4 cells lacking the chemokine receptor CXCR3 indicated a critical role ..
  58. Sex Differences and Estrogen Receptors Regulate Dendritic Cells in Inflammation
    Susan Kovats; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): SEX DIFFERENCES AND ESTROGEN RECEPTORS REGULATE DENDRITIC CELLS IN INFLAMMATION Abstract Autoimmune diseases such as rheumatoid arthritis and multiple sclerosis are strongly female biased, yet the ..
  59. Immunomodulation in melanoma therapy
    NOAH A CRAFT; Fiscal Year: 2012
    ..We hypothesize that stimulation of TLR7 leads to activation, maturation, and migration of dendritic cells (DCs) to the tumor site and to the draining lymph nodes...
  60. Immunomodulatory Mechanisms of Withafarin A in Her-2 neu breast cancer
    ANNALISE ROXANNE SMITH; Fiscal Year: 2013
    ..death by eliciting tumor specific response by the host, through activation of innate immune cells such as dendritic cells (DCs) and subsequent stimulation of adaptive immunity...
  61. Functional analysis of Phospholipase D4
    David Nemazee; Fiscal Year: 2010
    ..including B cells, with highest levels in endosomal compartments of myeloid cells, especially plasmacytoid dendritic cells. Very low, but detectable, levels of expression are also seen in T cells...
  62. CHEMOKINE RECEPTOR DYNAMICS IN GRANULOMA FORMATION
    Stephen W Chensue; Fiscal Year: 2013
    ..Initial analyses suggested that CCR4 mediates interactions with antigen presenting dendritic cells (DCs) to promote survival or maturation of Th effector/memory cells...
  63. Immune activation by cetuximab in head and neck cancer patients
    Robert L Ferris; Fiscal Year: 2013
    ..Released from activated NK cells, these cytokines and chemokines are chemotactic for T cells and dendritic cells (DC) cells, suggesting a potential link between cetuximab-induced NK lysis and induction of TA-specific T ..
  64. Neurogenic inflammation and psoriasiform dermatitis
    NICOLE LEANNE WARD; Fiscal Year: 2013
    ..surgical elimination of all nerve fibers entering dorsal skin of KC-Tie2 mice, a 40% decrease in CD11c+ dendritic cells (DCs) was observed beginning 1 day (d) following surgery, followed by a 30% improvement in acanthosis by 7d ..
  65. MECHANISMS OF SALMONELLA INVASION AND TRANSMIGRATION
    James E Casanova; Fiscal Year: 2013
    ..Recent evidence indicates the existence of a novel population of lysozyme-expressing dendritic cells unique to the Peyer's patch, that are the first cells targeted by Salmonella upon transiting the ..
  66. Cpdm: Cloning a Gene That Regulates Eosinophil Function
    JOHN PAUL SUNDBERG; Fiscal Year: 2013
    ..b>Dendritic cells play a pivotal role in directing the type of immune and inflammatory responses...
  67. Impact of aryl hydrocarbon receptor ligand ingestion on gastrointestinal immunity
    Barbara Platzer; Fiscal Year: 2013
    ..ligands promote food allergic responses by changing the mucosal microenvironment through activation of AhR in dendritic cells and intestinal epithelial cells, two key cell types for the regulation of mucosal immunity...
  68. Regulatory T Cells as a Novel Therapeutic Agent/Target for Acute Kidney Injury
    Gilbert R Kinsey; Fiscal Year: 2013
    ..the innate immune response to kidney injury through suppression of a specific innate pathway involving dendritic cells, natural killer T cells and neutrophils, and that pharmacological stimulation of A2A receptors will enhance ..
  69. Quiescent Tc17 programmed CD8 T cells and their role in graft versus host disease
    CAMERON JOHN TURTLE; Fiscal Year: 2013
    ..training in hematology/oncology in Australia, and then obtained a PhD studying the biology of human dendritic cells (DCs) with Derek Hart with the goal of utilizing DCs to generate virus- and tumor-specific CD8+ T cell ..
  70. Immune function and the progression to type 1 diabetes
    Mark A Atkinson; Fiscal Year: 2013
    ..g., frequency and function of iNKT cells, maturation of dendritic cells, interactions between regulatory and effector T cells, cytokin production, etc.)...
  71. INNATE AND ADAPTIVE IMMUNITY IN IBD
    Charles O Elson; Fiscal Year: 2013
    ..the enteric bacterial flora drives this pathologic response, and that the innate immune system (epithelium, dendritic cells, macrophages) is a critical link between these two elements...
  72. Fruit exosome-like particles for therapeutic delivery of extracellular miRNAs
    Huang Ge Zhang; Fiscal Year: 2013
    ..miR155 encapsulated in EPNV promotes differentiation of myeloid derived suppressor cells (MDSCs) into mature dendritic cells in mouse breast/brain tumor models;(3) Determine whether a therapeutic dose of miRNA17 or miRNA155 delivered ..
  73. Interferon Effects on HIV Transmission in Human Models
    Judy Lieberman; Fiscal Year: 2013
    ..The lack of efficient HIV replication in dendritic cells also effectively suppresses interferon production by most dendritic cell subsets...
  74. TNIP1 risk haplotypes and immune endophenotypes
    Peter K Gregersen; Fiscal Year: 2013
    ..on transitional, naive and memory B cells, as well as monocytes and in vitro monocyte derived macrophages and dendritic cells. Allele specific expression will also be investigated in major T cell subsets...
  75. Detection &Use of Novel Therapeutics to Stimulate NLRP3 Activity in the Elderly
    HEATHER WINONA STOUT-DELGADO; Fiscal Year: 2013
    ..which have been previously shown to promote K+ efflux, augmented IL-1[unreadable] expression by elderly dendritic cells (DC) as well as increased gene expression of NLRP3 inflammasome components and augmented caspase-1 activity ..
  76. Exosome-induced innate and antigen-specific immune responses in Type 1 Diabetes
    Yang D Dai; Fiscal Year: 2013
    ..that a diabetes- associated candidate gene, Slc11a1, could alter the pathways of processing islet antigens in dendritic cells (DC)...
  77. Intestinal Antigen Presenting Cells and Mucosal Immunity
    Timothy L Denning; Fiscal Year: 2013
    ..propria (LP) antigen presenting cell network is incredibly complex with several subsets of macrophages and dendritic cells (DCs) that differ phenotypically, functionally, and regionally along the length of the mouse intestine during ..
  78. 3-Dimensional modeling of basal cell function in pseudostratified epithelia
    Sylvie Breton; Fiscal Year: 2013
    ..mice available in our laboratory, including CD11c-YFP mice that express the yellow fluorescent protein in dendritic cells, and B1-EGFP mice that express the green fluorescent protein EGFP in epididymal clear cells, non- ciliated ..
  79. Thrombomodulin Receptors on Immune Cells
    John Morser; Fiscal Year: 2013
    ..TM also catalyzes the inactivation of complement factor C3b. We have shown that TM treatment of dendritic cells (DCs) changes their properties from causing asthma (immunogenic) to ameliorating asthma (tolerogenic) in a ..
  80. Myeloid Lineage Differentiation and Osteoclast Priming by a Novel Pax5 Cytokine
    Mark C Horowitz; Fiscal Year: 2013
    ..It is now well accepted that osteoclasts, like macrophages, granulocytes and dendritic cells, are members of the myeloid lineage arising from hematopoietic stem cells...
  81. Alcohol-induced Osteoimmunopathies: A Unifying Explanatory Mechanism
    ROBERT WADE SIGGINS; Fiscal Year: 2013
    ..linked through the effects of alcohol on the cell that is the origin of both osteoclasts and myeloid dendritic cells (mDCs): the osteoclast-dendritic cell (ODC) progenitor...
  82. Fifth World Congress of Leishmaniasis 2013
    Lynn Soong; Fiscal Year: 2013
    ..Leishmania are protozoan parasites that infect neutrophils, dendritic cells, and macrophages...
  83. Mast cell dependent inflammatory cascade during influenza A virus infection
    Joshua J Obar; Fiscal Year: 2013
    ..in the lungs include alveolar epithelial cells, endothelial cells, tissue resident alveolar macrophages, dendritic cells, and mast cells...
  84. Depletion of Dendritic Cells by Immunotoxin as Therapy for Myocardial Infarction
    Michael W Fanger; Fiscal Year: 2013
    ..In a murine model we have shown that temporary depletion of dendritic cells (DC) during MI wound healing results in an 80% improvement in cardiac function and a 65% reduction in MI size...
  85. Enhancing dendritic cell migration to drive potent anti-tumor immune responses
    Kristen Batich; Fiscal Year: 2013
    ..The use of dendritic cells (DCs) as cancer vaccine adjuvants is a promising strategy to induce anti- tumor immune responses, and we are ..
  86. Regulation of Type I IFNs in Tolerance and Autoimmunity
    Stefania Gallucci; Fiscal Year: 2013
    ..player in the regulation of the innate and the adaptive immune responses, primarily through the activation of dendritic cells (DCs)...
  87. Regulation of Macrophage Activation by House Dust Mite
    Achsah D Keegan; Fiscal Year: 2013
    ..While others have studied the effects of HDM on epithelial and dendritic cells, we have found that HDM directly activates macrophages, a cell that is central in the innate immune system ..
  88. C-reactive Protein, Autoimmunity, and Inflammation in the Central Nervous System
    Tyler T Wright; Fiscal Year: 2013
    ..I hypothesize that CRP mediated amelioration of EAE is manifest via CRP binding to Fc?RIIB on dendritic cells (DCs), and that local CNS expression of CRP is sufficient to achieve this benefit...
  89. Palmitic Acid Regulation of Dendritic Cell Toll-Like Receptor 4 Signaling
    DEQUINA ANGELINA NICHOLAS; Fiscal Year: 2013
    ..PA has been shown to act on dendritic cells (DCs), the immune cells that coordinate adaptive immune responses by regulating T cell activity...
  90. Development of lung T cell responses in infant respiratory immunity
    Donna L Farber; Fiscal Year: 2013
    ..We will also determine the role of T cells, dendritic cells (DCs) and cytokines in immune protection and pathology during influenza infection, and whether manipulation ..
  91. Transgenerational Susceptibility to Asthma from Air Pollution Exposure
    Lester Kobzik; Fiscal Year: 2013
    ..allergic responses and an asthma-like phenotype in F1 offspring, linked to epigenetic changes in offspring dendritic cells (DCs...
  92. Correction of myeloid cell defects in cancer
    Dmitry I Gabrilovich; Fiscal Year: 2013
    ..cell differentiation is diverted from its intrinsic pathway of differentiation to mature myeloid cells (dendritic cells (DC), macrophages (M[unreadable]), and granulocytes) towards differentiation of pathological MDSCs...
  93. Neutrophil Subsets in Post-Viral Asthma
    Dorothy S Cheung; Fiscal Year: 2013
    ..and requires induction of the high affinity receptor for IgE (Fc[unreadable]RI) on mouse lung conventional dendritic cells (cDC)...
  94. Influenza vaccination using a microneedle patch
    Mark R Prausnitz; Fiscal Year: 2013
    ..coverage by enabling self-administration and specifically designed to improve immunogenicity by targeting dendritic cells in skin...
  95. Regulation of Lung Inflammation by Catecholamines and Adrenergic Receptors
    Peter A Ward; Fiscal Year: 2013
    ..In Aim 1, we will evaluate lung dendritic cells (DCs), lung macrophages and alveolar epithelial cells (AECs) for the presence of a2 adrenergic receptors (a2A,..
  96. Exosome RNA-Therapeutics to Promote CNS Myelination
    Richard P Kraig; Fiscal Year: 2013
    ..The project has four Aims: AIM 1: Establish interferon-gamma (IFN-γ) -stimulated dendritic cells (DCs) as an effective source of exosomes that mimic EE-exosomes to enhance remyelination without injury or ..
  97. 16th International Congress of Mucosal Immunology (ICMI 2013)
    Joanne L Viney; Fiscal Year: 2013
    ..sessions on regulatory T-cells, the immunology of the epithelium, vaccines and mucosal infections, dendritic cells, cytokines, urogenital immunology, pulmonary immunology, inflammation, allergy, inflammatory bowel disease, ..
  98. Regulation of Intestinal Immune Homeostasis by APCs and Lymphocytes
    Duke Geem; Fiscal Year: 2013
    ..Our studies suggest that intestinal macrophages and dendritic cells (DCs) are distinct in their localization and ability to induce Treg and Th17 differentiation...
  99. Mechanisms of Immune Memory Regulation by PD-1
    Surojit Sarkar; Fiscal Year: 2013
    ..Because PD-1 is expressed widely on CD4 T cells, CD8 T cells, B cells, monocytes, dendritic cells, etc...
  100. Role of SHP-1 in monocyte-mediated demyelination
    Paul T Massa; Fiscal Year: 2013
    ..enter the white matter following peripheral TMEV inoculation differentiate into either mature macrophages or dendritic cells within demyelinating lesions and function in demyelination...
  101. Post-transcriptional regulation of the Dendritic Cell transcriptome
    Miriam Merad; Fiscal Year: 2013
    ..b>Dendritic cells (DCs) play an important role in ensuring proper regulation of the immune system...