antigen presenting cells


Summary: Heterogeneous group of immunocompetent cells that mediates the cellular immune response by processing and presenting antigens to the T-cell receptor. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. Follicular dendritic cells (DENDRITIC CELLS, FOLLICULAR) are also considered to be antigen-presenting cells by some authors.

Top Publications

  1. ncbi Extracellular HSP70 binding to surface receptors present on antigen presenting cells and endothelial/epithelial cells
    Jimmy R Theriault
    Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 21 27 Burlington Avenue, Boston, MA 02215, USA
    FEBS Lett 579:1951-60. 2005
  2. ncbi Immunopathogenesis of Behçet's disease with special emphasize on the possible role of antigen presenting cells
    Salih Pay
    Division of Rheumatology, Department of Medicine, Gulhane Military School of Medicine, Etlik Ankara, Turkey
    Rheumatol Int 27:417-24. 2007
  3. pmc Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer
    Catherine M Bollard
    Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children s Hospital, Houston, TX 77030, USA
    Blood 110:2838-45. 2007
  4. ncbi Heat shock protein derivatives for delivery of antigens to antigen presenting cells
    Makiya Nishikawa
    Department of Biopharmaceutics and Drug Metabolism, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Int J Pharm 354:23-7. 2008
  5. ncbi T cell receptor signaling precedes immunological synapse formation
    Kyeong Hee Lee
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid, Box 8118, Saint Louis, MO 63110, USA
    Science 295:1539-42. 2002
  6. ncbi Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4
    C C Chang
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Nat Immunol 3:237-43. 2002
  7. ncbi Cross-presentation by intercellular peptide transfer through gap junctions
    Joost Neijssen
    Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nature 434:83-8. 2005
  8. ncbi B cells as antigen presenting cells
    Daniel Rodriguez-Pinto
    Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, P O Box 208020, New Haven, CT 06520, USA
    Cell Immunol 238:67-75. 2005
  9. ncbi Staging and resetting T cell activation in SMACs
    Benjamin A Freiberg
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
    Nat Immunol 3:911-7. 2002
  10. pmc Respiratory syncytial virus induces prostaglandin E2, IL-10 and IL-11 generation in antigen presenting cells
    H Bartz
    Klinik für Kinder und Jugendmedizin der Ruhr Universität im St Josef Hospital, Bochum, Germany
    Clin Exp Immunol 129:438-45. 2002

Detail Information

Publications380 found, 100 shown here

  1. ncbi Extracellular HSP70 binding to surface receptors present on antigen presenting cells and endothelial/epithelial cells
    Jimmy R Theriault
    Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 21 27 Burlington Avenue, Boston, MA 02215, USA
    FEBS Lett 579:1951-60. 2005
    ..Previous reports suggest that HSP70 interacts with antigen presenting cells (APC) through a plethora of surface receptors...
  2. ncbi Immunopathogenesis of Behçet's disease with special emphasize on the possible role of antigen presenting cells
    Salih Pay
    Division of Rheumatology, Department of Medicine, Gulhane Military School of Medicine, Etlik Ankara, Turkey
    Rheumatol Int 27:417-24. 2007
  3. pmc Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer
    Catherine M Bollard
    Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children s Hospital, Houston, TX 77030, USA
    Blood 110:2838-45. 2007
    ..This study is registered at (protocol IDs: BCM-H-9936, NCT00062868, NCT00070226)...
  4. ncbi Heat shock protein derivatives for delivery of antigens to antigen presenting cells
    Makiya Nishikawa
    Department of Biopharmaceutics and Drug Metabolism, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Int J Pharm 354:23-7. 2008
    Delivery of antigens to antigen presenting cells (APCs) is a key issue for developing effective cancer vaccines...
  5. ncbi T cell receptor signaling precedes immunological synapse formation
    Kyeong Hee Lee
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid, Box 8118, Saint Louis, MO 63110, USA
    Science 295:1539-42. 2002
    ..These data suggest that many hours of TCR signaling are not required for T cell activation. These observations challenge current ideas about the role of immunological synapses in T cell activation...
  6. ncbi Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4
    C C Chang
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Nat Immunol 3:237-43. 2002
    ..These findings demonstrate an important mechanism of immune regulation...
  7. ncbi Cross-presentation by intercellular peptide transfer through gap junctions
    Joost Neijssen
    Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nature 434:83-8. 2005
    ..system of two adjacent cells and is lost in most tumours: gap-junction-mediated intercellular peptide coupling for presentation by bystander MHC class I molecules and transfer to professional antigen presenting cells for cross-priming.
  8. ncbi B cells as antigen presenting cells
    Daniel Rodriguez-Pinto
    Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, P O Box 208020, New Haven, CT 06520, USA
    Cell Immunol 238:67-75. 2005
    ..Thus, detailed understanding of the antigen presenting function of B cells can lead to their use for the generation or inhibition of immune responses...
  9. ncbi Staging and resetting T cell activation in SMACs
    Benjamin A Freiberg
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
    Nat Immunol 3:911-7. 2002
    ..We propose that pre-SMAC signals are sufficient to activate cell adhesion, but not productive T cell responses, which require orchestrated signaling in SMACs...
  10. pmc Respiratory syncytial virus induces prostaglandin E2, IL-10 and IL-11 generation in antigen presenting cells
    H Bartz
    Klinik für Kinder und Jugendmedizin der Ruhr Universität im St Josef Hospital, Bochum, Germany
    Clin Exp Immunol 129:438-45. 2002
    ..Since IL-10, IL-11 and PGE2 are known to act immunosuppressive rather than proinflammatory, these mediators might be responsible for the delayed protective RSV specific immune response...
  11. ncbi Cell biology of antigen processing in vitro and in vivo
    E Sergio Trombetta
    Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, Connecticut 06520 8002, USA
    Annu Rev Immunol 23:975-1028. 2005
    ..How dendritic cells handle antigens is likely to be as important a determinant of immunogenicity and tolerance as is the nature of the antigens themselves...
  12. ncbi T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    S P Schoenberger
    Department of Immunohematology and Blood Bank, University Hospital Leiden, The Netherlands
    Nature 393:480-3. 1998
    ..Blockade of CD40L inhibits CTL priming; this inhibition is overcome by signalling through CD40. CD40-CD40L interactions are therefore vital in the delivery of T-cell help for CTL priming...
  13. ncbi Altered TCR signaling from geometrically repatterned immunological synapses
    Kaspar D Mossman
    Biophysics Graduate Group, University of California, Berkeley, CA 94720, USA
    Science 310:1191-3. 2005
    ..These results are consistent with a model of the synapse in which spatial translocation of TCRs represents a direct mechanism of signal regulation...
  14. ncbi HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells
    Joel Lemaoult
    Service de Recherches en Hemato Immunologie, Commissariat à L Energie Atomique DRM DSV, Institut Universitaire d Hematologie, Hopital Saint Louis, Paris, France
    FASEB J 19:662-4. 2005
    ..Functionally, up-regulation of inhibitory receptors in immune cells before stimulation might increase their activation thresholds and participate in immune escape mechanisms...
  15. ncbi Selective modulation of protein kinase C-theta during T-cell activation
    C R Monks
    Division of Basic Sciences, National Jewish Center for Immunology, Denver, Colorado 80206, USA
    Nature 385:83-6. 1997
    ..Several modes of partial T-cell activation that failed to cause PKC-theta translocation also failed to cause T-cell proliferation, further suggesting the involvement of PKC-theta in T-cell activation...
  16. ncbi Maternal antigen presenting cells are a source of plasmatic HLA-G during pregnancy: longitudinal study during pregnancy
    Estibaliz Alegre
    Department of Biochemistry, University Clinic of Navarra, Pamplona, Spain
    Hum Immunol 68:661-7. 2007
    ..of plasmatic soluble HLA-G (sHLA-G: shed HLA-G1 plus HLA-G5) during pregnancy, and if peripheral maternal antigen presenting cells (APC) can be a source of sHLA-G...
  17. ncbi Synthetic surfaces as artificial antigen presenting cells in the study of T cell receptor triggering and immunological synapse formation
    Darrell J Irvine
    Department of Materials Science and Engineering and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Semin Immunol 19:245-54. 2007
    ..receptors engage peptide-major histocompatibility complex (pMHC) molecules displayed on the surface of antigen presenting cells (APCs)...
  18. ncbi Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis
    A D Weinberg
    Earle A Chiles Research Institute, Robert W Franz Cancer Research Center, Providence Portland Medical Center, Portland, OR 97213, USA
    J Immunol 162:1818-26. 1999
    ..Furthermore, the data suggest that agents designed to inhibit the OX-40L/OX-40R complex may be useful for treating autoimmune disease...
  19. ncbi In vivo MHC class II presentation of cytosolic proteins revealed by rapid automated tandem mass spectrometry and functional analyses
    A R Dongre
    Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle 98195, USA
    Eur J Immunol 31:1485-94. 2001
    ..These results suggest that central tolerance to at least some MHC class II-bound self peptides derived from cytosolic proteins exists in vivo...
  20. ncbi Pituitary adenylate cyclase-activating polypeptide (PACAP) ameliorates experimental autoimmune encephalomyelitis by suppressing the functions of antigen presenting cells
    Hideki Kato
    Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Mult Scler 10:651-9. 2004
    ..IL-12, and expression of the costimulatory factor B7-2 on macrophage and microglia, which may function as antigen presenting cells (APC) in the CNS...
  21. pmc CD26 up-regulates expression of CD86 on antigen-presenting cells by means of caveolin-1
    Kei Ohnuma
    Department of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 101:14186-91. 2004
  22. ncbi Functional specialization of antigen presenting cells in the gastrointestinal tract
    Maria Rescigno
    European Institute of Oncology, Department of Experimental Oncology, Via Adamello 16, 20139 Milan, Italy
    Curr Opin Immunol 22:131-6. 2010
    ..players in these responses, including dendritic cells, macrophages, B cells and basophils as professional antigen presenting cells (APCs), and stromal cells and epithelial cells as non-professional APCs...
  23. ncbi Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand
    I S Grewal
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 378:617-20. 1995
  24. ncbi Immunosuppressive networks in the tumour environment and their therapeutic relevance
    Weiping Zou
    Tulane University Health Sciences Center, Section of Hematology and Medical Oncology, 1430 Tulane Avenue, New Orleans, Louisiana 70112 2699, USA
    Nat Rev Cancer 5:263-74. 2005
    ..Why then has tumour immunotherapy resulted in a generally poor clinical efficiency? The reason might lie in the increasingly documented fact that tumours develop diverse strategies that escape tumour-specific immunity...
  25. ncbi Characterization of a new member of the TNF family expressed on antigen presenting cells
    C Tribouley
    Chiron Corporation, Emeryville, CA 94608 2916, USA
    Biol Chem 380:1443-7. 1999
    ..TNFSF20 is expressed at the surface of antigen presenting cells such as cells of the macrophagemonocyte lineage and dendritic cells...
  26. ncbi Expression and function of Toll-like receptors on dendritic cells and other antigen presenting cells from non-human primates
    Chutitorn Ketloy
    Vaccine and Cellular Immunology Laboratory, Chulalongkorn University, Bangkok, Thailand
    Vet Immunol Immunopathol 125:18-30. 2008
    b>Antigen presenting cells (APCs), especially dendritic cells (DCs), play a crucial role in immune responses against infections by sensing microbial invasion through Toll-like receptors (TLRs)...
  27. ncbi Imaging antigen-induced PI3K activation in T cells
    Julie Harriague
    Departement de Biologie Cellulaire, Institut Cochin, INSERM U567, CNRS UMR 7627, Universite Rene Descartes, 22 rue Mechain, 75014 Paris, France
    Nat Immunol 3:1090-6. 2002
    ..In T cell-APC conjugates, PIP3 accumulated at the T cell-APC synapse as well as in the rest of the T cell plasma membrane, which indicated unusual regulation of PI3K activity during antigen presentation...
  28. pmc Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse
    C Nataraj
    Division of Nephrology, Duke University and Durham Veterans Affairs Medical Centers, Durham, NC 27705, USA
    J Clin Invest 108:1229-35. 2001
    ..PGE(2) regulates cellular immune responses through distinct EP receptors on different immune cell populations: EP2 receptors directly inhibit T cell proliferation while EP2 and EP4 receptors regulate antigen presenting cells functions.
  29. ncbi Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis
    I S Grewal
    Howard Hughes Medical Institute, and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Science 273:1864-7. 1996
    ..1(+) antigen-presenting cells (APCs). Thus, CD40L is required to induce costimulatory activity on APCs for in vivo activation of CD4(+) T cells to produce IFN-gamma and to evoke autoimmunity...
  30. ncbi WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation
    Ines M Anton
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Immunity 16:193-204. 2002
    ..Both WIP-deficient T and B cells show a profound defect in their subcortical actin filament networks. These results suggest that WIP is important for immunologic synapse formation and T cell activation...
  31. ncbi DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide
    M A Sherman
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Immunity 3:197-205. 1995
    ..We conclude that DM is a cofactor that enhances peptide binding to DR molecules through a mechanism involving peptide exchange...
  32. ncbi Immunomodulatory effects of lactoferrin on antigen presenting cells
    Patrizia Puddu
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Biochimie 91:11-8. 2009
    ..fully elucidated yet, evidence indicates that the capacity of this molecule to directly interact with antigen presenting cells (APCs), i.e. monocytes/macrophages and dendritic cells (DCs), may play a critical role...
  33. pmc Chloroquine enhances human CD8+ T cell responses against soluble antigens in vivo
    Daniele Accapezzato
    Fondazione Andrea Cesalpino, Dipartimento di Medicina Interna, Universita degli Studi di Roma La Sapienza, Rome, Italy
    J Exp Med 202:817-28. 2005
    ..Our results suggest that chloroquine treatment improves CD8 immunity during vaccination...
  34. ncbi TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation
    Jennifer Hartt Meyers
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 6:455-64. 2005
    ..These data suggest that the TIM-1-TIM-4 interaction is involved in regulating T cell proliferation...
  35. ncbi Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action
    U T Phan
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 275:25907-14. 2000
    ..We also show that processing of precursor GILT can be mediated by multiple lysosomal proteases and provide evidence that the mechanism of action of GILT resembles that of other thiol oxidoreductases...
  36. pmc Regulation of T-cell immunity by leucocyte immunoglobulin-like receptors: innate immune receptors for self on antigen-presenting cells
    Katie J Anderson
    Centre for Infection, St George s University of London, Cranmer Terrace, London, UK
    Immunology 127:8-17. 2009
    ..We discuss the relevance of LILR-mediated immune regulation across a range of scenarios from autoimmunity to transplant medicine, infection and cancer...
  37. ncbi Network-based gene expression analysis of intracranial aneurysm tissue reveals role of antigen presenting cells
    B Krischek
    Department of Neurosurgery, University of Tubingen, Tubingen, Germany
    Neuroscience 154:1398-407. 2008
    ..Our results offer strong evidence for MHC class II gene overexpression in human IA tissue and that antigen presenting cells (macrophages, monocytes) play a key role in IA formation.
  38. ncbi Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: involvement of impaired integrin activation and immunologic synapse formation
    Maximilian Zeyda
    Medical University of Vienna, Vienna, Austria
    Arthritis Rheum 52:2730-9. 2005
    ..In this study, we evaluated the impact of the active leflunomide metabolite teriflunomide on T cell integrin activation, evolution of the IS, and antigen-specific formation of stable T cell/APC conjugates...
  39. pmc Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells
    Yoshihisa Kaizuka
    The Howard Hughes Medical Institute and the Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 104:20296-301. 2007
    ..Our results reveal that TCR and adhesion molecules spatially partition from one another well before the formation of a mature IS and that differential actin interactions help to shape and maintain the final bull's-eye pattern of the IS...
  40. ncbi When killers become helpers
    Jacob Hanna
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University, Hadassah Medical School, Jerusalem 91120, Israel
    Trends Immunol 28:201-6. 2007
    ..Such functions include promoting placental tissue development, antigen presentation and stimulation of T cells, priming of macrophages and dendritic cells, reducing transplant tissue rejection and several others...
  41. ncbi Immunogenicity of apoptotic cells in vivo: role of antigen load, antigen-presenting cells, and cytokines
    A Ronchetti
    Laboratorio di Immunologia dei Tumori, Cancer Immunotherapy and Gene Therapy Program, Unita di Epidemiologia, Universita Vita e Salute, Istituto Scientifico H San Raffaele, Milan, Italy
    J Immunol 163:130-6. 1999
  42. ncbi The preferential ability of B lymphocytes to act as diabetogenic APC in NOD mice depends on expression of self-antigen-specific immunoglobulin receptors
    Pablo A Silveira
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Eur J Immunol 32:3657-66. 2002
    ..Hence, defects in B lymphocyte, as well as T lymphocyte, tolerance induction mechanisms may contribute to T1D in NOD mice...
  43. ncbi Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    Loredana Ruggeri
    Department of Clinical and Experimental Medicine, Section of Hematology and Clinical Immunology, Perugia University School of Medicine, Perugia, Italy
    Science 295:2097-100. 2002
    ..NK cell alloreactivity may thus provide a powerful tool for enhancing the efficacy and safety of allogeneic hematopoietic transplantation...
  44. ncbi Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    Eva V Acosta-Rodriguez
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:942-9. 2007
  45. ncbi A critical role for Stat3 signaling in immune tolerance
    Fengdong Cheng
    Department of Interdisciplinary Oncology, University of South Florida, Tampa, FL 33612, USA
    Immunity 19:425-36. 2003
    ..Stat3 signaling provides, therefore, a novel molecular target for manipulation of immune activation/tolerance, a central decision with profound implications in autoimmunity, transplantation, and cancer immunotherapy...
  46. pmc In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines
    Franck J Barrat
    DNAX Research Institute, Department of Immunology, Palo Alto, CA 94304, USA
    J Exp Med 195:603-16. 2002
    ..Generating homogeneous populations of IL-10-producing T cells in vitro will thus facilitate the use of regulatory T cells in immunotherapy...
  47. ncbi Neuropeptide Y (NPY) suppresses experimental autoimmune encephalomyelitis: NPY1 receptor-specific inhibition of autoreactive Th1 responses in vivo
    Sammy Bedoui
    Department of Immunology, National Institute of Neuroscience, NCNP, Ogawahigashi, Kodaira, Tokyo, Japan
    J Immunol 171:3451-8. 2003
    ..Taken together, we conclude that NPY is a potent immunomodulator involved in the regulation of the Th1-mediated autoimmune disease EAE...
  48. ncbi Dynamics of immune cell recruitment during West Nile encephalitis and identification of a new CD19+B220-BST-2+ leukocyte population
    Anne Claire Brehin
    Neuro Immunologie Virale, Institut Pasteur, Paris, France
    J Immunol 180:6760-7. 2008
    ..G8-ICs express high levels of MHC class II, stain for viral Ag, and are localized in the paracortical zone of lymph nodes, strongly suggesting they are previously unidentified APCs that appear in response to viral infection...
  49. pmc Regulatory functions of CD8+CD28- T cells in an autoimmune disease model
    Nader Najafian
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Clin Invest 112:1037-48. 2003
    ..These are the first data establishing that regulatory CD8+CD28- T cells occur in normal mice and play a critical role in disease resistance in CD28-/- animals...
  50. ncbi Superantigen-induced regulatory T cells display different suppressive functions in the presence or absence of natural CD4+CD25+ regulatory T cells in vivo
    Susanna Grundström
    Active Biotech Research AB, Lund, Sweden
    J Immunol 170:5008-17. 2003
  51. ncbi Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse
    Tasha N Sims
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Cell 129:773-85. 2007
    ..WASp(-/-) T cells displayed normal IS formation but were unable to reform IS after migration unless PKCtheta was inhibited. Thus, opposing effects of PKCtheta and WASp control IS stability through pSMAC symmetry breaking and reformation...
  52. ncbi Imaging immune cell interactions and functions: SMACs and the Immunological Synapse
    Abraham Kupfer
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Semin Immunol 15:295-300. 2003
  53. ncbi Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex
    Line Mari Flornes
    Department of Anatomy, University of Oslo, 0317 Oslo, Norway
    Immunogenetics 56:506-17. 2004
    ..In all three species, the genes map together, forming an evolutionary conserved gene complex, which we call the antigen presenting lectin-like receptor complex (APLEC)...
  54. ncbi Mouse and human dendritic cell subtypes
    Ken Shortman
    Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
    Nat Rev Immunol 2:151-61. 2002
    ..Therefore, we must study the dynamics of the DC network in response to microbial invasion. Despite the difficulty of comparing the DC systems of humans and mice, recent work has revealed much common ground...
  55. pmc A population dynamics analysis of the interaction between adaptive regulatory T cells and antigen presenting cells
    David Fouchet
    Institute of Integrative Biology, Die Eidgenössische Technische Hochschule Zentrum, Zurich, Switzerland
    PLoS ONE 3:e2306. 2008
    ..An understanding of the network of the interaction between regulatory T cells, antigen presenting cells and effector T cells is starting to emerge...
  56. ncbi Interaction of T cells with APCs: the serial encounter model
    P Friedl
    Cell Migration Laboratory, Dept of Dermatology, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Trends Immunol 22:187-91. 2001
    ..Here, we develop a serial encounter model of T-cell activation and discuss how the summation of multiple signals provides an efficient strategy to control an ongoing immune response...
  57. ncbi A new role for B cells in systemic autoimmunity: B cells promote spontaneous T cell activation in MRL-lpr/lpr mice
    O Chan
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    J Immunol 160:51-9. 1998
    ..These results suggest a novel role for B cells in autoimmune disregulation...
  58. ncbi Perforin gene defects in familial hemophagocytic lymphohistiocytosis
    S E Stepp
    Department of Pathology and the Graduate Program in Immunology, University of Texas Southwestern Medical School, Dallas, TX 75235, USA
    Science 286:1957-9. 1999
    ..Thus, defects in perforin are responsible for 10q21-22-linked FHL. Perforin-based effector systems are, therefore, involved not only in the lysis of abnormal cells but also in the down-regulation of cellular immune activation...
  59. ncbi A novel immunoglobulin superfamily junctional molecule expressed by antigen presenting cells, endothelial cells and platelets
    F Malergue
    CIML INSERM CNRS, Universite de la Mediterranee, Case 906, Marseille, France
    Mol Immunol 35:1111-9. 1998
    ..It is also expressed by platelets and MHC class II+ antigen presenting cells in thymic medulla and T-cell areas in peripheral lymphoid organs...
  60. ncbi Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    S R Bennett
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, PO The Royal Melbourne Hospital, Victoria, Australia
    Nature 393:478-80. 1998
  61. ncbi Cutting edge: biasing immune responses by directing antigen to macrophage Fc gamma receptors
    Charles F Anderson
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Immunol 168:3697-701. 2002
    ..These studies demonstrate that the ligation of FcgammaR on activated macrophages can reverse the Th1 biasing that occurs as a result of innate immune responses to microbial products...
  62. pmc Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity
    Anish Suri
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:2268-76. 2005
    ..These results are in striking contrast to those from studies examining synthetic peptide or phage display libraries, in which many peptides were shown to bind...
  63. pmc The proliferative capacity of individual naive CD4(+) T cells is amplified by prolonged T cell antigen receptor triggering
    Adam G Schrum
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 196:793-803. 2002
    ..These data demonstrate that TCR triggering and consumption can occur over an extended period of time, with a significant impact on the effector responses evoked from naive CD4(+) T cells...
  64. ncbi Basophils as antigen presenting cells
    Mohan S Maddur
    INSERM, U872, Paris, France
    Trends Immunol 31:45-8. 2010
    Recent reports demonstrate that basophils act as antigen presenting cells to drive Th2 and IgE responses against protease and protein allergens and helminth parasites...
  65. pmc Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block
    Melanie P Matheu
    Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697 4561, USA
    Immunity 29:602-14. 2008
    ..3 channels in Tem cells during an inflammatory immune response in peripheral tissues. Targeting Kv1.3 allows for effector memory responses to be suppressed while central memory responses remain intact...
  66. pmc Interaction of Cowpea mosaic virus (CPMV) nanoparticles with antigen presenting cells in vitro and in vivo
    Maria J Gonzalez
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 4:e7981. 2009
    ..In particular, it is important to understand the interactions of a potential vaccine with antigen presenting cells (APCs) of the immune system...
  67. pmc Real-time imaging of lymphocytes in vivo
    Michael D Cahalan
    Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA
    Curr Opin Immunol 15:372-7. 2003
    ..The view is emerging that lymphocytes migrate randomly within lymphoid organs, and that lymphocyte contact with antigen-presenting cells may be a stochastic process rather than one guided by chemokine gradients...
  68. pmc Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand
    K Murata
    Department of Microbiology and Immunology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    J Exp Med 191:365-74. 2000
    ..Collectively, these results provide convincing evidence that OX40L, expressed on APCs, plays a critical role in antigen-specific T cell responses in vivo...
  69. ncbi Contact-dependent induction of regulatory antigen-presenting cells by human mesenchymal stem cells is mediated via STAT3 signaling
    Devorah Gur-Wahnon
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Exp Hematol 35:426-33. 2007
    ..However, the molecular mechanisms that block initiation of immune responses by MSCs remains to be investigated...
  70. ncbi T lymphocyte costimulation mediated by reorganization of membrane microdomains
    A Viola
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    Science 283:680-2. 1999
    ..These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains...
  71. pmc Acute in vivo exposure to interferon-gamma enables resident brain dendritic cells to become effective antigen presenting cells
    Andres Gottfried-Blackmore
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:20918-23. 2009
    Dendritic cells (DC) are the professional antigen presenting cells (APC) that bridge the innate and adaptive immune system...
  72. ncbi Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness
    Shaul Beyth
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel
    Blood 105:2214-9. 2005
    ..Our data may reveal a physiologic phenomenon whereby the development of a distinct APC population is regulated by the tissue's cellular microenvironment...
  73. ncbi Defective antigen processing in GILT-free mice
    M Maric
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 294:1361-5. 2001
    ..The response to hen egg lysozyme, a model antigen with a compact structure containing four disulfide bonds, was examined in detail...
  74. ncbi Human papillomavirus-like particles mediate functional delivery of plasmid DNA to antigen presenting cells in vivo
    Christine M Malboeuf
    Department of Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Vaccine 25:3270-6. 2007
    ..Interestingly, in these experiments we routinely observed GFP expression in migrating antigen presenting cells (APC) recovered from mice inoculated with GFP plasmid in combination with VLPs, but not in APC recovered ..
  75. ncbi [Phenotype expression and function of antigen presenting cells in huaman gammadelta T cells activated by peptide antigen from Mycobacterium tuberculosis]
    Jing Wang
    Department of Immunology, Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu 233030, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25:588-91. 2009
    ..To explore whether the human peripheral gammadelta T cells stimulated by polypeptide heat resistant antigen from Mycobacterium tuberculosis (Mtb-HAg) express phenotype and have the fuction of antigen presentation...
  76. ncbi Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21
    Jacqueline D Shields
    Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Science 328:749-52. 2010
    ..We suggest that by altering the tumor microenvironment, CCL21-secreting tumors shift the host immune response from immunogenic to tolerogenic, which facilitates tumor progression...
  77. ncbi Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse; involvement of SNARE complexes
    Vincent Das
    Unite de Biologie des Interactions Cellulaires, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2582, 75724 Paris Cedex 15, France
    Immunity 20:577-88. 2004
  78. ncbi Number and function of circulating human antigen presenting cells regulated by sleep
    Stoyan Dimitrov
    Department of Neuroendocrinology, University of Lubeck, Germany
    Sleep 30:401-11. 2007
  79. ncbi Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs
    Jason G Cyster
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143 0414, USA
    Annu Rev Immunol 23:127-59. 2005
    ..Here, we review the steps associated with the initiation of adaptive immune responses in secondary lymphoid organs, highlighting the roles of chemokines and S1P...
  80. ncbi SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates
    Hongyan Wang
    Department of Haematology, Division of Investigative Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Nat Immunol 4:366-74. 2003
    ..Our findings identify a mechanism by which SKAP-55 modulates T cell responses to antigen...
  81. ncbi Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate
    Lelia Delamarre
    Department of Cell Biology and Department of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, Post Office Box 208002, New Haven, CT 06520 8002, USA
    Science 307:1630-4. 2005
    ..Limited lysosomal proteolysis also favored antigen presentation. These results help explain why DCs are able to efficiently accumulate, process, and disseminate antigens and microbes systemically for purposes of tolerance and immunity...
  82. ncbi Quantitating protein synthesis, degradation, and endogenous antigen processing
    Michael F Princiotta
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Immunity 18:343-54. 2003
  83. ncbi Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses
    Pramod Srivastava
    Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, Connecticut 06030 1601, USA
    Annu Rev Immunol 20:395-425. 2002
    ..Heat shock proteins also interact with antigen presenting cells through CD91 and other receptors, eliciting a cascade of events including re-presentation of heat shock ..
  84. pmc Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation
    C D Gimmi
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA
    Proc Natl Acad Sci U S A 90:6586-90. 1993
    ..The artificial antigen-presenting system provides a useful model for the investigation of the biochemical events involved in the generation of tolerance and for the study of signals necessary to overcome tolerance...
  85. pmc Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells
    David Q Shih
    Inflammatory Bowel Disease Center and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Eur J Immunol 39:3239-50. 2009
    ..Our findings suggest a role for TL1A in pro-inflammatory APC-T cell interactions and implicate TL1A in host responses to enteric microorganisms...
  86. ncbi Preferential recognition of self antigens despite normal thymic deletion of CD4(+)CD25(+) regulatory T cells
    Paola Romagnoli
    Institut National de la Sante et de la Recherche Medicale, Claude de Preval Institute, Purpan Hospital, Toulouse, France
    J Immunol 168:1644-8. 2002
    ..Combined, our data firmly establish that the repertoire of regulatory T cells is specifically enriched in autospecific cells despite the fact that their precursors are normally susceptible to thymic deletion...
  87. ncbi Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology
    C Asselin-Paturel
    Schering-Plough, Laboratory for Immunological Research, Dardilly, France
    Nat Immunol 2:1144-50. 2001
    ..Although different pathogens can selectively engage various APC subsets for IL-12 production, IFN-alpha production is restricted to mIPCs' response to viral infection...
  88. ncbi High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells
    John S Manavalan
    Department of Pathology and Internal Medicine, Columbia University, 630 West 168th Street, P and S 14 401, New York, NY 10032, USA
    Transpl Immunol 11:245-58. 2003
  89. pmc Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis
    Sushmita Sinha
    Neuroimmunology Research R and D 31, Portland VA Medical Center, Portland, OR 97239, USA
    J Neuroimmunol 225:52-61. 2010
    ..These results demonstrate a novel pathway of T cell regulation by RTL-bound APCs...
  90. ncbi Direct observation of ligand recognition by T cells
    Darrell J Irvine
    Department of Microbiology and Immunology and the Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 419:845-9. 2002
    ..T-cell receptors with antigenic peptide bound to major histocompatibility complex (MHC) on the surface of antigen presenting cells (APCs) is a crucial step in adaptive immunity...
  91. ncbi Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses
    I Gramaglia
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 161:6510-7. 1998
    ..These data suggest that Ox-40/Ox-40L interactions act after initial activation events to prolong clonal expansion and enhance effector cytokine secretion, and may be involved in promoting long-lived primary CD4 responses...
  92. ncbi Ex vivo induction and expansion of antigen-specific cytotoxic T cells by HLA-Ig-coated artificial antigen-presenting cells
    Mathias Oelke
    Department of Pathology and Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Nat Med 9:619-24. 2003
    ..These studies show the value of HLA-Ig-based aAPCs for reproducible expansion of disease-specific CTLs for clinical approaches to adoptive immunotherapy...
  93. pmc Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses
    Koko Katagiri
    Department of Molecular Immunology and Allergy, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 22:1001-15. 2002
    ..Moreover, constitutive Rap1 activation rendered T cells unresponsive with accumulation of p27(Kip1). Our study indicates that the activation state of Rap1 has a decisive effect on the T-cell response to antigen...
  94. ncbi Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation
    Diana Gil
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, Madrid 20849, Spain
    Cell 109:901-12. 2002
    ..Finally, by interfering with Nck-CD3 epsilon association in vivo, we demonstrate that TCR-CD3 recruitment of Nck is critical for maturation of the immune synapse and for T cell activation...
  95. ncbi HDAC6 deacetylase activity links the tubulin cytoskeleton with immune synapse organization
    Juan M Serrador
    Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, E 28006 Madrid, Spain
    Immunity 20:417-28. 2004
    ..Our results underscore the key role for HDAC6 in the organization of the immune synapse and the antigen-specific reorientation of the MTOC...
  96. ncbi Rafting MHC-II domains in the APC (presynaptic) plasma membrane and the thresholds for T-cell activation and immunological synapse formation
    Imre Gombos
    Department of Immunology, Eotvos Lorand University, Budapest, Hungary
    Immunol Lett 92:117-24. 2004
    ..Our data also demonstrate that B-cells, similarly to dendritic cells, could also provide T-cells with antigen-independent weak survival signals, likely associated with integrin engagement...
  97. pmc T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells
    Jiankun Zhu
    Simmons Arthritis Research Center, Division of Rheumatology, Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8884, USA
    J Clin Invest 115:1869-78. 2005
  98. ncbi Thrombospondin orchestrates the tolerance-promoting properties of TGFbeta-treated antigen-presenting cells
    Sharmila Masli
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    Int Immunol 18:689-99. 2006
    ..We conclude that TSP-1, an ECM protein induced by TGFbeta treatment, orchestrates the changes in APC functional programs that equip these cells to promote tolerance of the eye-derived type...
  99. pmc Mycobacterium bovis BCG decreases MHC-II expression in vivo on murine lung macrophages and dendritic cells during aerosol infection
    Nicole D Pecora
    Department of Pathology, Case Western Reserve University, Wolstein 6534, 10900 Euclid Avenue, Cleveland, OH 44106 7288, USA
    Cell Immunol 254:94-104. 2009
    ..Thus, lung APCs that harbor mycobacteria in vivo have decreased MHC-II expression relative to uninfected APCs from the same lung, possibly contributing to evasion of T cell responses...
  100. ncbi Targeting of Jak/STAT pathway in antigen presenting cells in cancer
    Yulia Nefedova
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    Curr Cancer Drug Targets 7:71-7. 2007
    One of the major mechanisms of tumor escape is the inability of antigen presenting cells (APC), and specifically the most potent APC dendritic cells (DC), to induce potent antitumor immune response...
  101. pmc Inhibitory CD8+ T cells in autoimmune disease
    Masakatsu Suzuki
    The Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Emory University, Atlanta, GA, USA
    Hum Immunol 69:781-9. 2008
    ..Underlying mechanisms involve conditioning of antigen presenting cells (APC)...

Research Grants73

  1. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  2. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2012
    ..Our goal is to develop tissue regenerative biomaterials that will also provide a short-term defense and life long immune response to specific bacterial infections ..
  3. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..Successful completion of the study will lead to improved health outcome of a significant number of patients by decreasing the need for indefinite use of non-specific immunosuppressants in transplant recipients. ..
  4. Induction and maintenance of regulatory T cells
    Mitchell Kronenberg; Fiscal Year: 2013
    ..types of Treg are altered by viral infections, and we will determine how the innate responses by antigen presenting cells to viruses mediate effects on Treg. In Project 4 led by Dr...
    Chella David; Fiscal Year: 2009
    ..we will study mechanism of remission during pregnancy by studying function of T regulatory cells and antigen presenting cells. Recent literature has shown a protective/ susceptible effect of non-inherited maternal antigen (NIMA) on ..
  6. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
    ..This study of the immunological basis of preeclampsia will result in new therapies to combat this complication during pregnancy. Hence, the welfare of affected families and society will be considerably improved. ..
  7. Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
    Alexandra L Howell; Fiscal Year: 2013
    ..These professional antigen presenting cells (APC) also endocytose HIV-1 and present viral peptides to responding T cells in association with HLA ..
  8. Modeling TH17 Cells in Acute GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2010
    ..This work has the capacity to fundamentally alter our perceptions of the biology of GVHD and offer new avenues for therapy. ..
  9. Retroviral Vector-mediated Liver Gene Therapy for MPS I
    Katherine P Ponder; Fiscal Year: 2013
    ..This study will also test to see if there are any adverse effects of gene therapy. This may result in a treatment for patients with this severe genetic disease. ..
  10. Mindfulness Based Stress Reduction as an Adjunctive Treatment for Psoriasis
    Jan A Moynihan; Fiscal Year: 2013
    ..Cytokines (small molecular weight messenger proteins) produced by T helper (Th)1 and Th17 lymphocytes, antigen presenting cells, and leukocytes have been implicated as being critical to the development of lesions...
  11. Engineering the Brain Immune System for Tumor Therapy
    Maria G Castro; Fiscal Year: 2013
    ..e. the blood-brain barrier, a lack of proper antigen presenting cells (i.e...
  12. Characterization of IL36, a novel cytokine
    Albert Zlotnik; Fiscal Year: 2012
    ..Since several antigen presenting cells express IL36, we hypothesize that IL36 affects T cell activation and may also influence their ..
    Kwang Chul Kim; Fiscal Year: 2010 is likely that the absence of MUC1/Muc1 in DC will significantly affect their function as antigen presenting cells. If this can be proven through this exploratory/developmental grant mechanism, we plan to extend this ..
    Sandra M McLachlan; Fiscal Year: 2012
    ..Moreover, we will test the efficacy of an approach to block autoimmune responses to the thyrotropin receptor in order to prevent or treat Graves'disease, initially in mice and ultimately in humans. ..
  15. Gold Nanoparticle Assisted Delivery of Cancer Vaccines and Immune Stimulants
    Adam Lin; Fiscal Year: 2013
    ..drainage due to their small size, simplistic synthesis/conjugation process and passively collection in antigen presenting cells. Although peptide conjugations on to AuNPs are not new, this proposal aim to be the first to utilize ..
  16. Biologic Activities of IL-36 Cytokines in Psoriasis
    Andrew Johnston; Fiscal Year: 2013
  17. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2012
    ..HIFU would provide a source of tumor cell-derived HSP-peptide complex as tumor antigens for professional antigen presenting cells, such as, dendritic cells, and thereby induce a strong tumor-specific systemic immune response that would ..
    Arthur A Vandenbark; Fiscal Year: 2013
    ..Our studies will provide unique insights into the mechanisms of RTL therapy for EAE in mice, with implications for similar evaluations in subjects with MS. ..
  19. Predictors of Immunologic Failure in Older Adults
    David H Canaday; Fiscal Year: 2012
    ..To test this hypothesis, a panel of established immunologic tests to measure the function of T cells, antigen presenting cells (APC), and B cells in older adults that are robust (healthy), pre-frail, and frail as measured by a ..
  20. Molecular Mechanisms of Ion Channels in T Lymphocytes
    Michael D Cahalan; Fiscal Year: 2013
    ..Overall, our project will provide fundamental insights into the Orai1 proteins that are currently being targeted for treatment of autoimmune disorders and chronic inflammatory conditions. ..
  21. Modeling distinct neonatal purine metabolism to inform vaccine development
    Ofer Levy; Fiscal Year: 2013
    ..These studies will provide insight into neonatal immunity, establish novel platforms for studying immune ontogeny, assess Ado-refractory adjuvants, and inform neonatal vaccine development. ..
  22. Sex Differences and Estrogen Receptors Regulate Dendritic Cells in Inflammation
    Susan Kovats; Fiscal Year: 2010
    ..and ER1 signaling as critical regulators of differentiation and activation of dendritic cells (DC), antigen presenting cells essential for initiation of innate and adaptive immunity...
  23. Mechanisms of Sensitization in High Risk Corneal Grafts
    Reza Dana; Fiscal Year: 2013
  24. Microneedle-based immunization against pandemic influenza
    Mark R Prausnitz; Fiscal Year: 2011 evaluate the efficacy of influenza vaccines delivered using microneedles and determine the role of antigen presenting cells in immune activation...
  25. Define the role of dendritic cells in HTLV-1 associated neuroinflammatory disease
    Pooja Jain; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dendritic cells (DCs) are the most potent antigen presenting cells and are recognized as key regulators of the immune system, linking both stimulatory and inhibitory components of normal immunity...
  26. Functional Genomics Approach to the Role of the JAK/STAT and MAPK Pathway in CBD
    Li Li; Fiscal Year: 2013
    ..focused on the cell-cell immunological synapse interactions between activated memory T lymphocytes and antigen presenting cells. In addition, she received his first academic appointment at National Jewish Health (NJH) in the Division ..
  27. Immunomodulatory Mechanisms of Withafarin A in Her-2 neu breast cancer
    ANNALISE ROXANNE SMITH; Fiscal Year: 2013
    ..immunity by up-regulation of cytokines such as interferon gamma, induction of co-stimulatory molecules on antigen presenting cells and increased proliferation of T cells (Malik et al., 2009, Stan et al., 2009)...
  28. Regulation of Organized Intestinal Lymphoid Tissues by TRANCE/RANKL
    Ifor R Williams; Fiscal Year: 2012
    ..These studies are expected to contribute to existing knowledge of how specific imbalances in the intestinal immune system can lead to various forms of human inflammatory bowel disease. ..
  29. Functional analysis of Phospholipase D4
    David Nemazee; Fiscal Year: 2010
    ..Particularly close homologues to PLD4 are found in pox viruses. PLD4 is expressed in a variety of antigen presenting cells, including B cells, with highest levels in endosomal compartments of myeloid cells, especially ..
  30. Integration of mucosal immune responses through the enteric nervous system
    DANIEL S MUCIDA; Fiscal Year: 2013
  31. TAM receptor tyrosine kinases in inflammatory bowel disease
    Carla Rothlin; Fiscal Year: 2013
    ..Our studies focus on a novel, yet fundamental anti-inflammatory signaling pathway - TAM pathway - in antigen presenting cells (APCs) of the immune system and our objective is to better understand the function of this pathway in the ..
    Stephen W Chensue; Fiscal Year: 2013
    ..may utilize CCR4 for tissue mobilization, but Th2 central memory is sustained through alternative antigen presenting cells. This hypothesis will be tested under conditions of Mycobacterium bovis and Schistosoma mansoni exposure ..
  33. Tomotherapy and Hematopoietic Stem Cells For Tolerance to Kidney Transplants
    Samuel Strober; Fiscal Year: 2013
    ..a challenge with a donor and third party skin graft to assess the role of tolerogenic versus immunogenic antigen presenting cells (APCs) in graft outcome...
  34. Targeting the oral cavity epithelium for inducing mucosal immunity against HIV
    Harvinder Singh Gill; Fiscal Year: 2012
    ..DCs are potent antigen presenting cells that can help induce strong mucosal immunity by processing the antigen and presenting it to T-cells ..
  35. Suppression of Collagen Induced Arthritis with Altered Peptide Ligands
    Andrew H Kang; Fiscal Year: 2010
    ..Our hypothesis was that introducing critical alterations into the interaction between antigen presenting cells and potentially pathogenic T cells would suppress autoimmune arthritis...
  36. Placental Treg Activation and Pregnancy Outcome in the FIV-infected Cat Model
    GREGORY TODD PHARR; Fiscal Year: 2010
    ..microenvironment will include indoleamine 2,3-dioxygenase (IDO), an immunosuppressive enzyme produced by antigen presenting cells (APCs) and trophoblasts, cytokines INF-c, TNF-", IL-1b, IL-2, IL-6, and IL-12, produced by APCs, ..
  37. Toward suicidal automation of porphyric Leishmania for photodynamic vaccination
    Kwang Poo Chang; Fiscal Year: 2010
    ..The outcome of the study will help us produce a universal carrier to deliver vaccines for preventing and treating infectious and non-infectious diseases. ..
  38. Vaccines to promote Tc-1-based targeting of tumor stroma
    Walter J Storkus; Fiscal Year: 2013 the TME, enhanced tumor cell death and corollary cross-priming of anti-tumor T cells sponsored by host antigen presenting cells (APC) would be expected...
  39. Novel mechanisms of immune activation following allogeneic, hematopoietic stem ce
    JOHN JAMES LETTERIO; Fiscal Year: 2013
    ..of GVHD is complex and fundamentally depends upon interactions between donor T cells and host antigen presenting cells. Experimental and clinical data support the hypothesis that cytokine dysregulation during GVHD occurs in ..
  40. Innate Regulation and CD4+Th1/17 Immunity in TMEV-Induced Demyelination
    Stephen D Miller; Fiscal Year: 2013 disease in different strains of inbred mice, and to determine the role of dendritic cells, specialized antigen presenting cells of the innate immune system, both in inducing virus immunity in the acute stages of the disease and in ..
  41. Antigen presentation by epithelial stem cells to promote life long immunity
    ..progeny cells differentiate, the promoter will become activated and the daughter cells will become, in a sense, antigen presenting cells leading to induction of humoral and cellular immune response via direct priming and cross-priming.
  42. HA Surface Presented Yeast Flu Vaccine and Its Enhancement by CD154 Codisplay
    Kaiming Ye; Fiscal Year: 2012
    ..The codisplay of HA with CD154 will further stimulate the maturation of antigen presenting cells and promote the adaptive immune response...
  43. Effects of apoptotic epithelial cell engulfment on mucosal inflammation
    Peter B Ernst; Fiscal Year: 2010
    ..b>Antigen presenting cells (APC), including macrophages and dendritic cells, can remove bacteria, cellular debris and dead cells ..
  44. Development of Vaccine Strategies to prevent EBV+ Lymphoma in Patients with HIV
    ROBERT ALAN BAIOCCHI; Fiscal Year: 2010
    ..We cloned several EBV genes into an adeno-associated and adenoviral constructs, infected human antigen presenting cells and demonstrated robust autologous T cell expansion...
  45. Enhancement of Dendritic Cells After Burn Injury
    Tracy Toliver Kinsky; Fiscal Year: 2009
    ..Dendritic cells are antigen presenting cells that activate both innate and acquired immune responses...
  46. Epithelium, dendritic cells, and Clostridium difficile associated colitis
    Hanping Feng; Fiscal Year: 2013
    ..The interaction of intestinal epithelial cells (IECs) with intestinal antigen presenting cells (APCs), such as dendritic cells (DCs) and macrophages, in the gut orchestrates mucosal immune homeostasis ..
  47. Use of Allogenicity to Stimulate Effector Responses Against Multiple Myeloma
    Christina N Johnson; Fiscal Year: 2013
    ..3, to investigate the impact of allogeneic variation on CTL responses, the complexes will be delivered to antigen presenting cells using a novel application of the lentiviral vector system...
  48. GILT and regulation of Treg development in cutaneous autoimmunity
    KAREN TARASZKA HASTINGS; Fiscal Year: 2013
    ..GILT is an enzyme in the lysosomal compartment of antigen presenting cells that is critical for efficient processing of disulfide bond- containing antigens...
    Michael J Bevan; Fiscal Year: 2012
    ..This contribution may be via the activation of antigen presenting cells or via secretion of cytokines, such as IL-2, which may signal directly to the CD8+ T cells...
  50. Keratinocyte regulation of skin immunity
    Anthony A Gaspari; Fiscal Year: 2013
    ..We hypothesize that Keratinocytes (KC) are tolerigenic Antigen presenting cells for Natural killer (NK)T-cells...
  51. Development of a Next Generation Vaccine for Smoking Cessation and Relapse Preven
    Grayson B Lipford; Fiscal Year: 2010
    ..Selecta's technology consists of synthetic immunomodulatory nanoparticles that home to antigen presenting cells (dendritic cells and B cells) to drive focused and highly prolific antigen-specific immune responses...
    Yongwon Choi; Fiscal Year: 2010
    ..Thus, understanding molecular and cellular pathways that properly control immune responses will provide the foundation for novel intervention strategies to treat various chronic inflammatory diseases. ..
  53. Phase 1 Study of Umbilical Cord Blood-Derived T Cells in Malignant B Cells
    Elizabeth J Shpall; Fiscal Year: 2013
    ..T cells can be rapidly and selectively propagated to clinically-sufficient numbers on designer artificial antigen presenting cells (aAPC) expressing CD19...
    Shahriar Yaghoubi; Fiscal Year: 2013
    ..propagated in presence of cytocidal concentration of hygromycin B on γ- irradiated artificial antigen presenting cells that co-express CD19 along with desired T-cell co-stimulatory molecules...
  55. miRNAs and epidermal langerhans cell development and function
    Qing Sheng Mi; Fiscal Year: 2011
  56. Mechanisms used by skin dendritic cells to induce regulatory T cells
    Juliana Idoyaga; Fiscal Year: 2013
    ..naturally generated in the thymus, or can be induced de novo from CD4+ naive T cells in the periphery by antigen presenting cells, especially dendritic cell (DCs)...
  57. A Novel IgE Cancer Therapeutic Specific for the Epithelial Membrane Protein-2
    TRACY RUTH DANIELS-WELLS; Fiscal Year: 2013
    ..It is also expected that the dead cells would be phagocytosed by antigen presenting cells and cancer antigens would be presented to the immune system resulting in a secondary cancer-targeted ..
  58. Leukocyte Signaling in the Elderly and Vaccine Immunogenicity
    DAVID BRAM LEWIS; Fiscal Year: 2012
    ..These tests will help use current vaccines more effectively, and will also help in the development of a new, more potent vaccine for influenza that uses an adjuvant, a substance added to vaccines to boost the immune response. ..
  59. Role of B cells in pathogenesis of Collagen-induced Arthritis in Humanized Mice
    Veena Taneja; Fiscal Year: 2012
    ..In aim1, we will define the requirement of B cells as antigen presenting cells in pathogenesis of CIA...
  60. Imaging and Function of the Immunological Synapse
    David C Parker; Fiscal Year: 2012 applicant): T lymphocytes recognize antigen as small peptides bound to MHC molecules on the surface of antigen presenting cells (APC)...
  61. Mechanisms of Immune Modulation by Probiotics
    Lijuan Yuan; Fiscal Year: 2012
  62. Purification &Characterization of Adenosine Receptors
    Joel M Linden; Fiscal Year: 2009
    ..factors produced during acute ischemia- reperfusion injury are presented to certain T lymphocytes by antigen presenting cells (APCs) resulting in their rapid activation...
    GEORGE DEEPE; Fiscal Year: 2007
    ..pathogenic fungus, Histoplasma capsulatum (Hc), requires collaboration between T cells and professional antigen presenting cells such as macrophages and dendritic cells...
  64. ApoVax-SVN as a Novel Vaccine for Cancer Immunotherapy
    Haval Shirwan; Fiscal Year: 2007
    ..ApoImmune's novel immune system-based therapy, ApoVax104 vaccine, is a new, innovative approach to treating cancer and malignant neoplastic diseases. [unreadable] [unreadable] [unreadable]..
  65. Dual Antigen Nanoparticle Vaccine System For Bacillus Infectious Disease
    Puthupparampil Scaria; Fiscal Year: 2009 incorporate hydrophilic antigens efficiently and to deliver them in concert with advanced adjuvants to Antigen Presenting Cells in a manner that can induce a protective immune response...
  66. Exploration of novel pan-HPV treatments to block development of AIDS-associated c
    Wijbe Martin Kast; Fiscal Year: 2010
  67. Innate Immunity in Myocarditis
    Sally A Huber; Fiscal Year: 2010
    ..which provides an environmental milieu favorable to a specific Th response;and innate effector impact on antigen presenting cells resulting in changes in accessory molecule or cytokine expression by the antigen presenting cells leading ..
  68. Xenograft-like rejection of tumors in a-gal glycolipids
    URI GALILI GALILI; Fiscal Year: 2010
    ..within the tumor, activity of regulatory T (Treg) cells and lack of appropriate presentation of TAA by antigen presenting cells (APC)...
  69. Immunopathogenesis of Chronic Allograft Rejection
    MOHAMED SAYEGH; Fiscal Year: 2005
    ..abstract_text> ..
    VICTOR REYES; Fiscal Year: 2003
    ..our cells have shown that these epithelial cells express other important markers which are required by antigen presenting cells. We noted that gastric epithelial cells in vitro and in vivo expressed the CD86 co-stimulatory molecule ..
    MUYIWA EMMANUEL AWONIYI; Fiscal Year: 2010
    ..Following recognition of Stym by antigen presenting cells (APCs) via TLRs cytokines are produced to contain the infection during the first days and then promote ..
  72. Development and evaluation of a novel SOCS1-silenced HIV vaccine
    Jerry Blackwell; Fiscal Year: 2009
    ..The relevance of such an improvement lies in the development and potential global impact of a vaccine that affords protection from HIV infection. ..
  73. Role of Host Dendritic Cells in Heart Transplant Vasculopathy
    Zhiliang Wang; Fiscal Year: 2007
    ..We believe the data from the proposal will lead to better understanding of the pathogenesis and therapy of graft chronic rejection. [unreadable] [unreadable]..