plasma cells

Summary

Summary: Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)

Top Publications

  1. ncbi A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins
    Davide Corti
    Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland
    Science 333:850-6. 2011
  2. pmc microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells
    Elena Vigorito
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, CB22 3AT, UK
    Immunity 27:847-59. 2007
  3. ncbi Duration of humoral immunity to common viral and vaccine antigens
    Ian J Amanna
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    N Engl J Med 357:1903-15. 2007
  4. ncbi Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination
    Ulf Klein
    Institute for Cancer Genetics, Department of Pathology and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA
    Nat Immunol 7:773-82. 2006
  5. pmc IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
    Dimitra Zotos
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia
    J Exp Med 207:365-78. 2010
  6. ncbi Plasma cell development and survival
    Sarah A Oracki
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Australia
    Immunol Rev 237:140-59. 2010
  7. ncbi Antigen-specific memory B cell development
    Louise J McHeyzer-Williams
    The Scripps Research Institute, Department of Immunology, La Jolla, CA 92037, USA
    Annu Rev Immunol 23:487-513. 2005
  8. ncbi IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
    Rachel Ettinger
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
    J Immunol 175:7867-79. 2005
  9. ncbi A new clinicopathological entity of IgG4-related autoimmune disease
    Terumi Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3 18 22 Honkomagome, Bunkyo ku, 113 8677, Tokyo, Japan
    J Gastroenterol 38:982-4. 2003
  10. ncbi XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation
    A L Shaffer
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Immunity 21:81-93. 2004

Detail Information

Publications310 found, 100 shown here

  1. ncbi A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins
    Davide Corti
    Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland
    Science 333:850-6. 2011
    ..Using a single-cell culture method for screening large numbers of human plasma cells, we isolated a neutralizing monoclonal antibody that recognized the hemagglutinin (HA) glycoprotein of all 16 ..
  2. pmc microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells
    Elena Vigorito
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, CB22 3AT, UK
    Immunity 27:847-59. 2007
    ..1 regulation is a contributing factor to the miR-155-deficient phenotype. Our results implicate post-transcriptional regulation of gene expression for establishing the terminal differentiation program of B cells...
  3. ncbi Duration of humoral immunity to common viral and vaccine antigens
    Ian J Amanna
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    N Engl J Med 357:1903-15. 2007
    ..Maintenance of long-term antibody responses is critical for protective immunity against many pathogens. However, the duration of humoral immunity and the role played by memory B cells remain poorly defined...
  4. ncbi Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination
    Ulf Klein
    Institute for Cancer Genetics, Department of Pathology and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA
    Nat Immunol 7:773-82. 2006
    B cells producing high-affinity antibodies are destined to differentiate into memory B cells and plasma cells, but the mechanisms leading to those differentiation pathways are mostly unknown...
  5. pmc IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
    Dimitra Zotos
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia
    J Exp Med 207:365-78. 2010
    ..Long-lived memory B cells and plasma cells are also generated in GCs, although how B cell differentiation in GCs is regulated is unclear...
  6. ncbi Plasma cell development and survival
    Sarah A Oracki
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Australia
    Immunol Rev 237:140-59. 2010
    b>Plasma cells have long been recognized as the basis of humoral immunity, yet we are only now beginning to appreciate the complexities of plasma cell development and the fact that not all plasma cells are created equal...
  7. ncbi Antigen-specific memory B cell development
    Louise J McHeyzer-Williams
    The Scripps Research Institute, Department of Immunology, La Jolla, CA 92037, USA
    Annu Rev Immunol 23:487-513. 2005
    ..Cognate effector Th cell-B cell interactions then promote the development of either short-lived plasma cells (PCs) or germinal centers (GCs) (Phase II)...
  8. ncbi IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
    Rachel Ettinger
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
    J Immunol 175:7867-79. 2005
    ..were stimulated through the BCR, IL-21 induced minimal proliferation, IgD down-modulation, and small numbers of plasma cells. In contrast, after CD40 engagement, IL-21 induced extensive proliferation, class switch recombination (CSR), ..
  9. ncbi A new clinicopathological entity of IgG4-related autoimmune disease
    Terumi Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3 18 22 Honkomagome, Bunkyo ku, 113 8677, Tokyo, Japan
    J Gastroenterol 38:982-4. 2003
    ..Autoimmune pancreatitis (AIP) is occasionally associated with other autoimmune diseases...
  10. ncbi XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation
    A L Shaffer
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Immunity 21:81-93. 2004
    The differentiation of B cells into immunoglobulin-secreting plasma cells is controlled by two transcription factors, Blimp-1 and XBP1...
  11. ncbi Germinal center selection and the development of memory B and plasma cells
    Mark J Shlomchik
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Immunol Rev 247:52-63. 2012
    ..of sustained antibody titers and long-lived memory B cells (MBCs), with the former deriving from long-lived plasma cells (PCs)...
  12. ncbi The immune geography of IgA induction and function
    A J MacPherson
    Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Mucosal Immunol 1:11-22. 2008
    ..Peyer's patches, which then circulate through the lymph and bloodstream to seed the mucosa with precursors of plasma cells that produce dimeric IgA for export through the intestinal epithelium, has been known for more than 30 years...
  13. ncbi Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program
    A L Shaffer
    Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 17:51-62. 2002
    Blimp-1, a transcriptional repressor, drives the terminal differentiation of B cells to plasma cells. Using DNA microarrays, we found that introduction of Blimp-1 into B cells blocked expression of a remarkably large set of genes, while a ..
  14. ncbi Regulation of plasma-cell development
    Miriam Shapiro-Shelef
    Departments of Microbiology, and Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nat Rev Immunol 5:230-42. 2005
    b>Plasma cells are the terminally differentiated, non-dividing effector cells of the B-cell lineage. They are cellular factories devoted to the task of synthesizing and secreting thousands of molecules of clonospecific antibody each second...
  15. ncbi TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses
    Laurent Genestier
    Institut National de la Santé et de la Recherche Médicale Unité 851, IFR128 Biosciences Lyon Gerland, 21 Avenue Tony Garnier, Lyon, France
    J Immunol 178:7779-86. 2007
    ..However, TLR ligation leads to massive differentiation of B-1 and MZ B cells into mature plasma cells (PC) but only marginally promotes PC differentiation of FO B cells...
  16. ncbi Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation
    Roger Sciammas
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA
    Immunity 25:225-36. 2006
    ..We propose a gene-regulatory network in which graded expression of IRF-4 developmentally coordinates isotype switching with plasma cell differentiation...
  17. ncbi Dendritic cells from patients with myeloma are numerically normal but functionally defective as they fail to up-regulate CD80 (B7-1) expression after huCD40LT stimulation because of inhibition by transforming growth factor-beta1 and interleukin-10
    R D Brown
    Institute of Haematology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
    Blood 98:2992-8. 2001
    ..Serum TGF-beta1 and IL-10 levels were normal in most patients studied. Cytoplasmic TGF-beta1 was increased in plasma cells during progressive disease...
  18. ncbi Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells
    Miriam Shapiro-Shelef
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Immunity 19:607-20. 2003
    Blimp-1 is a transcriptional repressor able to drive the terminal differentiation of B cells into Ig-secreting plasma cells. We have created mice with a B cell-specific deletion of prdm1, the gene encoding Blimp-1...
  19. pmc BCMA is essential for the survival of long-lived bone marrow plasma cells
    BRIAN P O'CONNOR
    Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
    J Exp Med 199:91-8. 2004
    Long-lived humoral immunity is manifested by the ability of bone marrow plasma cells (PCs) to survive for extended periods of time...
  20. pmc PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells
    Kim L Good-Jacobson
    Department of Laboratory Medicine, Yale University, New Haven, Connecticut, USA
    Nat Immunol 11:535-42. 2010
    Memory B and plasma cells (PCs) are generated in the germinal center (GC)...
  21. ncbi Idiopathic chronic pancreatitis with periductal lymphoplasmacytic infiltration: clinicopathologic features of 35 cases
    Kenji Notohara
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Surg Pathol 27:1119-27. 2003
    ..One of these, lymphoplasmacytic sclerosing pancreatitis, is a histologically unique lesion and could be a pancreatic manifestation of idiopathic fibrosclerosing disorders...
  22. pmc BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone
    Jerome Moreaux
    Institut National de la Santé et de la Recherche Médicale U475 and Unité de Thérapie Cellulaire, Centre Hospitalier Universitaire Montpellier, Hopital St Eloi, France
    Blood 103:3148-57. 2004
    ..of 2 receptors for a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF) in malignant plasma cells compared with normal plasma cells...
  23. pmc Evidence of a role for activation of Wnt/beta-catenin signaling in the resistance of plasma cells to lenalidomide
    Chad C Bjorklund
    Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 286:11009-20. 2011
    ..these findings support the hypothesis that lenalidomide mediates activation of Wnt/β-catenin signaling in plasma cells as a mechanism of inducible chemoresistance through effects at the transcriptional and post-translational levels...
  24. ncbi The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis
    Kirsten Neubert
    Interdisciplinary Center for Clinical Research, research group N2, Nikolaus Fiebiger Center of Molecular Medicine, University Hospital Erlangen, Glückstrasse 6, 91054 Erlangen, Germany
    Nat Med 14:748-55. 2008
    ..In particular, long-lived plasma cells producing autoantibodies resist current therapeutic and experimental approaches...
  25. ncbi APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells
    Elodie Belnoue
    World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Departments of Pathology Immunology and Pediatrics, University of Geneva, Geneva, Switzerland
    Blood 111:2755-64. 2008
    ..Altogether, this identifies APRIL as a critical signal for PB survival that is poorly expressed in the early-life BM compartment...
  26. ncbi Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway
    Jizhong Liu
    Institut National de la Sante et de la Recherche Medicale, Unité 837, Institut de Recherche sur le Cancer de Lille, France
    Blood 110:296-304. 2007
    ..the expression of B7-H1 (PD-L1), a B7-related protein that inhibits T-cell responses, in CD138-purified plasma cells isolated from MM patients, monoclonal gammopathy of undetermined significance patients, and healthy donors...
  27. ncbi New criteria to identify risk of progression in monoclonal gammopathy of uncertain significance and smoldering multiple myeloma based on multiparameter flow cytometry analysis of bone marrow plasma cells
    Ernesto Pérez-Persona
    Department of Hematology, University Hospital, Salamanca, Spain
    Blood 110:2586-92. 2007
    ..We have previously shown that the proportion of bone marrow (BM) aberrant plasma cells (aPCs) within the BMPC compartment (aPC/BMPC) as assessed by flow cytometry (FC) contributes to differential ..
  28. ncbi Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL
    Micah J Benson
    Department of Microbiology and Immunology, Dartmouth Medical School, The Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    J Immunol 180:3655-9. 2008
    Memory B (B(MEM)) cells and long-lived bone marrow plasma cells (BM-PCs) persist within local environmental survival niches that afford cellular longevity...
  29. ncbi Plasticity and heterogeneity in the generation of memory B cells and long-lived plasma cells: the influence of germinal center interactions and dynamics
    Kim L Good-Jacobson
    Department of Laboratory Medicine, Yale University, New Haven, CT 06519, USA
    J Immunol 185:3117-25. 2010
    ..This arm comprises the germinal center response and its products: long-lived memory B (B(mem)) cells and plasma cells (PCs)...
  30. pmc A T cell-dependent mechanism for the induction of human mucosal homing immunoglobulin A-secreting plasmablasts
    Melissa Dullaers
    Baylor Institute for Immunology Research, Baylor Research Institute and INSERM 899, Dallas, TX 75204, USA
    Immunity 30:120-9. 2009
    Mucosal immunoglobulin A (IgA) secreted by local plasma cells (PCs) is a critical component of mucosal immunity...
  31. ncbi Numerous IgG4-positive plasma cells are ubiquitous in diverse localised non-specific chronic inflammatory conditions and need to be distinguished from IgG4-related systemic disorders
    Johanna D Strehl
    Institute of Pathology, University of Erlangen, Krankenhausstrasse 12, Erlangen, Germany
    J Clin Pathol 64:237-43. 2011
    ..recently defined disorder characterised by a diffuse or tumefactive inflammatory reaction rich in IgG4-positive plasma cells associated with sclerosis and obliterative phlebitis...
  32. pmc A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE
    Matilda W Nicholas
    Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Clin Immunol 126:189-201. 2008
    ..basal levels of phosphorylated Syk and ERK1/2, signal transduce in response to BCR crosslinking, and can become plasma cells (PCs) in vitro...
  33. ncbi Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice
    David J DiLillo
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 180:361-71. 2008
    ..The relationship between memory B cells, long-lived plasma cells, and long-lived humoral immunity also remains controversial...
  34. ncbi Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    J Immunol 173:5361-71. 2004
    ..although IL-21 induces death of resting B cells, it promotes differentiation of B cells into postswitch and plasma cells. Thus, IL-21 differentially influences B cell fate depending on the signaling context, explaining how IL-21 can ..
  35. ncbi Plasma cells: finding new light at the end of B cell development
    K L Calame
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nat Immunol 2:1103-8. 2001
    b>Plasma cells are cellular factories devoted entirely to the manufacture and export of a single product: soluble immunoglobulin (Ig). As the final mediators of a humoral response, plasma cells play a critical role in adaptive immunity...
  36. ncbi Hydronephrosis associated with retroperitoneal fibrosis and sclerosing pancreatitis
    Hideaki Hamano
    Second Department of Internal Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, 390 8621, Matsumoto, Japan
    Lancet 359:1403-4. 2002
    ..examined the ureteral and pancreatic lesions of these patients and noted abundant infiltration of IgG4-bearing plasma cells in both tissues. Treatment with corticosteroids lowered serum concentrations of IgG4...
  37. ncbi Memory B and memory plasma cells
    Taketoshi Yoshida
    Charité Centre 12, Clinic for Internal Medicine, Rheumatology, Clinical Immunology, Charite University Hospital Berlin, Berlin, Germany
    Immunol Rev 237:117-39. 2010
    ..Memory plasma cells, secreting protective antibodies over lifetime, have been recognized only recently...
  38. ncbi Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration
    Stefan Kuchen
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:5886-96. 2007
    ..These data are the first to document that B cell activation, expansion, and PC differentiation induced by direct interaction of B cells with activated T cells requires IL-21...
  39. ncbi Plasma-cell homing
    Eric J Kunkel
    BioSeek, Inc, Burlingame, California 94010, USA
    Nat Rev Immunol 3:822-9. 2003
    ..By directing plasma-cell homing, chemokines might help to determine the character and efficiency of mucosal, inflammatory and systemic antibody responses...
  40. ncbi Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses
    Mercedesz Balazs
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
    Immunity 17:341-52. 2002
    ..In the absence of soluble TACI ligands, Ag-activated MZ- and B1-derived blasts lack survival signals and undergo apoptosis, resulting in severely impaired antibody responses...
  41. pmc B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
    Danielle T Avery
    Immunology Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    J Exp Med 207:155-71. 2010
    ..Ag)-specific memory B cells and abolished the ability of IL-21 to induce naive B cells to differentiate into plasma cells (PCs). This resulted from impaired activation of the molecular machinery required for PC generation...
  42. pmc Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
    Jens Wrammert
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 453:667-71. 2008
    ..However, we found that most of the influenza-virus-specific mAbs showed the highest affinity for the current vaccine strain. Thus, OAS does not seem to be a common occurrence in normal, healthy adults receiving influenza vaccination...
  43. ncbi Mechanisms that determine plasma cell lifespan and the duration of humoral immunity
    Ian J Amanna
    Najít Technologies, Inc, Portland, OR, USA
    Immunol Rev 236:125-38. 2010
    ..Humoral immunity following vaccination or infection is mainly derived from two types of cells: memory B cells and plasma cells. Memory B cells do not actively secrete antibody but instead maintain their immunoglobulin in the membrane-..
  44. ncbi Eosinophils are required for the maintenance of plasma cells in the bone marrow
    Van Trung Chu
    Deutsches Rheuma ForschungsZentrum, Institut der Leibniz Gemeinschaft, Berlin, Germany
    Nat Immunol 12:151-9. 2011
    b>Plasma cells are of crucial importance for long-term immune protection. It is thought that long-lived plasma cells survive in specialized niches in the bone marrow...
  45. pmc CpG DNA activation and plasma-cell differentiation of CD27- naive human B cells
    Jennifer Huggins
    Department of Pathology, James P Wilmot Cancer Center, University of Rochester Medical Center, NY 14642, USA
    Blood 109:1611-9. 2007
    ..b>Plasma cells derived from CD27+ B cells were primarily IgG+, while those from CD27- B cells were IgM+...
  46. ncbi Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
    Gaetan Jego
    Baylor Institute for Immunology Research, 3434 Live Oak Street, Dallas, Texas 75204, USA
    Immunity 19:225-34. 2003
    ..Furthermore, purified pDCs triggered with virus induce CD40-activated B cells to differentiate into plasma cells. Two pDC cytokines act sequentially, with IFN-alphabeta generating non-Ig-secreting plasma blasts and IL-6 ..
  47. pmc ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity
    Jared M Odegard
    Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA
    J Exp Med 205:2873-86. 2008
    ..MRL(lpr) mice lacking the Icos gene have impaired extrafollicular differentiation of immunoglobulin (Ig) G(+) plasma cells accompanied by defects in CXC chemokine receptor (CXCR) 4 expression, interleukin (IL) 21 secretion, and B cell ..
  48. pmc STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation
    SEAN A DIEHL
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 180:4805-15. 2008
    ..Thus, up-regulation of BLIMP1 alone is not sufficient for differentiation of primary human B cells into plasma cells; concomitant down-regulation of BCL6 is absolutely required for completion of the plasma cell differentiation ..
  49. ncbi Maintenance of serum antibody levels
    Rudolf A Manz
    Deutsches Rheumaforschungszentrum, 10117 Berlin, Germany
    Annu Rev Immunol 23:367-86. 2005
    ..is the result of tightly regulated differentiation of B lymphocytes into antibody-secreting plasma blasts and plasma cells. The survival of antibody-secreting cells determines their contribution to the immune response in which they ..
  50. ncbi Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells
    C A Turner
    Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305 5428
    Cell 77:297-306. 1994
    ..Thus, Blimp-1 appears to be a pleiotropic regulatory factor capable of at least partially driving the terminal differentiation of B cells...
  51. ncbi High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions
    Roberto Di Niro
    Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
    Nat Med 18:441-5. 2012
    ..We found that TG2-specific plasma cells are markedly expanded within the duodenal mucosa in individuals with active celiac disease...
  52. ncbi High frequency of autoantibody-secreting cells and long-lived plasma cells within inflamed kidneys of NZB/W F1 lupus mice
    Charlotte Starke
    Department of Internal Medicine 3, Clinical Research Group, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Immunol 41:2107-12. 2011
    ..Self-reactive antibodies might be partially produced by long-lived plasma cells (PCs), which mainly reside within the bone marrow and spleen...
  53. ncbi Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow
    Oliver Winter
    Institute for Systemic Inflammation Research, University of Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Blood 116:1867-75. 2010
    Long-lived plasma cells in the bone marrow produce memory antibodies that provide immune protection persisting for decades after infection or vaccination but can also contribute to autoimmune and allergic diseases...
  54. ncbi Maintenance of serological memory by polyclonal activation of human memory B cells
    Nadia L Bernasconi
    Institute for Research in Biomedicine, Via Vela 6, CH 6500 Bellinzona, Switzerland
    Science 298:2199-202. 2002
    ..Here, we show that human memory B lymphocytes proliferate and differentiate into plasma cells in response to polyclonal stimuli, such as bystander T cell help and CpG DNA...
  55. ncbi Identifying intercellular signaling genes expressed in malignant plasma cells by using complementary DNA arrays
    J De Vos
    INSERM U475, Unit for Cellular Therapy, CHU Montpellier, 99 rue Puech Villa, 34197 Montpellier Cedex 5, France
    Blood 98:771-80. 2001
    In multiple myeloma (MM), the growth of primary plasma cells depends not only on interleukin-6 (IL-6), but also on additional unidentified signals delivered by the bone marrow environment...
  56. pmc Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study
    Gabor G Illei
    National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA
    Arthritis Rheum 62:542-52. 2010
    ..To assess the safety of interleukin-6 receptor inhibition and to collect preliminary data on the clinical and immunologic efficacy of tocilizumab in patients with systemic lupus erythematosus (SLE)...
  57. pmc Mcl-1 is essential for the survival of plasma cells
    Victor Peperzak
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Nat Immunol 14:290-7. 2013
    The long-term survival of plasma cells is entirely dependent on signals derived from their environment. These extrinsic factors presumably induce and sustain the expression of antiapoptotic proteins of the Bcl-2 family...
  58. ncbi Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Küttner's tumor)
    Satoshi Kitagawa
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, 13 1 Takaramachi, Kanazawa 920 8640, Japan
    Am J Surg Pathol 29:783-91. 2005
    ..Immunohistochemically, the proportion of IgG4/IgG-positive plasma cells was more than 45% in CSS, while it was less than 5% in controls...
  59. ncbi Plasma cell development: from B-cell subsets to long-term survival niches
    Kirsten A Fairfax
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
    Semin Immunol 20:49-58. 2008
    Recent advances in the identification of mouse plasma cells have enabled a more detailed assessment of their development and maintenance to be undertaken...
  60. ncbi Leukemic B cells clonally identical to myeloma plasma cells are myelomagenic in NOD/SCID mice
    Linda M Pilarski
    Department of Oncology, University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada
    Exp Hematol 30:221-8. 2002
    In multiple myeloma (MM), the immunoglobulin gene rearrangement characterizing malignant plasma cells is unique...
  61. ncbi IgA-producing plasma cells originate from germinal centers that are induced by B-cell receptor engagement in humans
    Francesca Barone
    Peter Gorer Department of Immunobiology, King s College London, Guy s Hospital, London, UK
    Gastroenterology 140:947-56. 2011
    ..We used multiple experimental approaches to investigate the origin of human intestinal plasma cells that produce IgA in the gastrointestinal tract.
  62. ncbi Distinctive pulmonary histopathology with increased IgG4-positive plasma cells in patients with autoimmune pancreatitis: report of 6 and 12 cases with similar histopathology
    Bijayee Shrestha
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Am J Surg Pathol 33:1450-62. 2009
    ..disease with elevated serum IgG4 and characteristic histopathology, including increased IgG4-positive (+) plasma cells in the tissue. The histopathology of pulmonary IgG4 disease has not been well established...
  63. ncbi Analysis of regulatory T cells and IgG4-positive plasma cells among patients of IgG4-related sclerosing cholangitis and autoimmune liver diseases
    Masanori Koyabu
    Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, 10 15 Fumizono, Moriguchi, Osaka, 570 8507, Japan
    J Gastroenterol 45:732-41. 2010
    ..However, the role of IgG4 in the development of IgG4-related SC (IgG4-SC) remains unclear. To clarify the role of IgG4 in IgG4-SC, we have performed an immunohistochemical analysis of the bile duct...
  64. ncbi Plasma cells and nonplasma B cells express differing IgE repertoires in allergic sensitization
    Tobias Rogosch
    Department of Pediatrics, Philipps University, Baldingerstrasse, D 35033 Marburg, Germany
    J Immunol 184:4947-54. 2010
    ....
  65. pmc Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells
    Sally K Martin
    Myeloma Research Program, Division of Haematology, Centre for Cancer Biology SA Pathology and University of Adelaide, Australia
    Haematologica 95:776-84. 2010
    Multiple myeloma is an incurable malignancy of bone marrow plasma cells. Progression of multiple myeloma is accompanied by an increase in bone marrow angiogenesis...
  66. ncbi IgG4-positive plasma cells in inflammatory pseudotumor (plasma cell granuloma) of the lung
    Yoh Zen
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    Hum Pathol 36:710-7. 2005
    ..Recently, we described IPTs of the liver and breast, into both of which many IgG4-positive plasma cells had infiltrated...
  67. ncbi Interleukin-6 is a growth factor for nonmalignant human plasmablasts
    G Jego
    , Institut de Biologie, Nantes, France
    Blood 97:1817-22. 2001
    ..The present study reinvestigated the roles of IL-6 and IL-2 in the generation of plasma cells from human memory B cells in vitro...
  68. ncbi Proteasome inhibition causes apoptosis of normal human plasma cells preventing alloantibody production
    D K Perry
    Division of Transplantation Surgery, Department of Surgery, von Leibig Transplant Center, Mayo Clinic College of Medicine, Rochester, MN, USA
    Am J Transplant 9:201-9. 2009
    Antibody production by normal plasma cells (PCs) against human leukocyte antigens (HLA) can be a major barrier to successful transplantation...
  69. ncbi Mast cells enhance proliferation of B lymphocytes and drive their differentiation toward IgA-secreting plasma cells
    Sonia Merluzzi
    Department of Biomedical Science and Technology, University of Udine, Udine, Italy
    Blood 115:2810-7. 2010
    ..on MCs, together with MC-derived cytokines, was involved in the differentiation of B cells into CD138(+) plasma cells and in selective immunoglobulin A (IgA) secretion...
  70. ncbi Chemotactic responsiveness toward ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response
    Anja E Hauser
    Deutsches Rheuma ForschungsZentrum Berlin, Germany
    J Immunol 169:1277-82. 2002
    ..to migrate into the bone marrow and into chronically inflamed tissues where they differentiate into long-lived plasma cells. In this study, we analyze the chemokine responsiveness of plasma blasts formed after secondary immunization ..
  71. ncbi Plasma cell differentiation requires the transcription factor XBP-1
    A M Reimold
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 412:300-7. 2001
    ..little is known about factors that control the transition of mature activated B cells to antibody-secreting plasma cells. Here we report that the transcription factor XBP-1 is required for the generation of plasma cells...
  72. ncbi Immunoglobin G4-hepatopathy: association of immunoglobin G4-bearing plasma cells in liver with autoimmune pancreatitis
    Takeji Umemura
    Department of Internal Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
    Hepatology 46:463-71. 2007
    ..The number of IgG4-bearing plasma cells was significantly higher in AIP patients than controls (P < 0...
  73. ncbi HLA-DRhigh/CD27high plasmablasts indicate active disease in patients with systemic lupus erythematosus
    A M Jacobi
    Charite Universitatsmedizin Berlin, Chariteplatz 1, 10098 Berlin, Germany
    Ann Rheum Dis 69:305-8. 2010
    ..A similar subset has also been identified 6-8 days after tetanus/diphtheria vaccination in normal individuals and in patients with infectious disease...
  74. pmc Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid
    Gregory P Owens
    Department of Neurology, University of Colorado Denver School of Medicine, Denver, CO 80045, USA
    Ann Neurol 65:639-49. 2009
    ..Nevertheless, the target antigen of this response remains enigmatic...
  75. ncbi The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expression
    Francisco Medina
    Servicio de Inmunologia, Hospital Universitario Puerta del Mar, Avenida Ana de Viya 21, 11009 Cadiz, Spain
    Blood 99:2154-61. 2002
    b>Plasma cells (PCs) are the final B-cell differentiation stage. Recent evidence reveals relevant functional differences within the PC compartment...
  76. ncbi Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
    Neal N Iwakoshi
    Department of Immunology and Infectious Diseases, Harvard School of Public Health 651 Huntington Avenue, Boston, Massachusetts 02115 6017, USA
    Nat Immunol 4:321-9. 2003
    The transcription factor X-box binding protein 1 (XBP-1) is essential for the differentiation of plasma cells and the unfolded protein response (UPR)...
  77. ncbi Transcriptional profiling of antigen-dependent murine B cell differentiation and memory formation
    Deepta Bhattacharya
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 179:6808-19. 2007
    Humoral immunity is characterized by the generation of Ab-secreting plasma cells and memory B cells that can more rapidly generate specific Abs upon Ag exposure than their naive counterparts...
  78. pmc The molecular classification of multiple myeloma
    Fenghuang Zhan
    Donna D and Donald M Lambert Laboratory of Myeloma Genetics, Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood 108:2020-8. 2006
    ..myeloma (MM), we performed unsupervised hierarchic clustering of mRNA expression profiles in CD138-enriched plasma cells from 414 newly diagnosed patients who went on to receive high-dose therapy and tandem stem cell transplants...
  79. ncbi IgG4-related sclerosing cholangitis with and without hepatic inflammatory pseudotumor, and sclerosing pancreatitis-associated sclerosing cholangitis: do they belong to a spectrum of sclerosing pancreatitis?
    Yoh Zen
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Am J Surg Pathol 28:1193-203. 2004
    ..Immunohistochemically, many IgG4-positive plasma cells were found in the bile duct lesions of all SP-SC cases, 4 SC cases with marked lymphoplasmacytic infiltration, ..
  80. pmc Plasma cells negatively regulate the follicular helper T cell program
    Nadege Pelletier
    Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, California, USA
    Nat Immunol 11:1110-8. 2010
    ..Here we demonstrate that isotype-switched plasma cells expressed major histocompatibility complex (MHC) class II, the costimulatory molecules CD80 and CD86, and the ..
  81. pmc B lymphocytes express and lose syndecan at specific stages of differentiation
    R D Sanderson
    Department of Pediatrics, Stanford University School of Medicine, California 94305
    Cell Regul 1:27-35. 1989
    ..Expression changes with pre-B cell maturation in the marrow and with B-lymphocyte differentiation to plasma cells in interstitial matrices...
  82. pmc An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization
    Michel Jourdan
    INSERM, U847, Montpellier, France
    Blood 114:5173-81. 2009
    Human plasma cells (PCs) and their precursors play an essential role in humoral immune response but are rare and difficult to harvest...
  83. ncbi Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors
    Jiquan Zhang
    Division of Cell Biology and Immunology, School of Life Sciences, Wellcome Trust Biocentre at Dundee, University of Dundee, Dundee DD1 5EH, United Kingdom
    Blood 107:3600-8. 2006
    ..Targeting Siglec-H may therefore be a useful way of delivering antigens to pDC precursors for cross-presentation...
  84. ncbi Protein synthesis in plasma cells is regulated by crosstalk between endoplasmic reticulum stress and mTOR signaling
    Meidan Goldfinger
    Institute for Drug Research, The School of Pharmacy, The Hebrew University, Jerusalem, Israel
    Eur J Immunol 41:491-502. 2011
    b>Plasma cells (PCs) secrete copious levels of immunoglobulins. To achieve this, their endoplasmic reticulum (ER) undergoes expansion in a process that requires continuous ER stress and activation of the unfolded protein response...
  85. ncbi ASK1 promotes apoptosis of normal and malignant plasma cells
    Fan Ru Lin
    Genomics Research Center, Academia Sinica, Taipei, Taiwan
    Blood 120:1039-47. 2012
    Although the overproduction of immunoglobulins by short-lived plasma cells accompanying an immune response links with their apoptosis, how long-lived plasma cells adapt to ensure their longevity in this context is obscure...
  86. ncbi V-region gene analysis of locally defined synovial B and plasma cells reveals selected B cell expansion and accumulation of plasma cell clones in rheumatoid arthritis
    Tobias Scheel
    Deutsches Rheuma ForschungsZentrum, Berlin, Germany
    Arthritis Rheum 63:63-72. 2011
    ..tissue-specific B cell immune responses, the clonality of individual naive B cells, memory B cells, and plasma cells and their organization and histologic localization in the inflamed tissue were investigated in patients with ..
  87. ncbi Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells
    Fenghuang Zhan
    Donna D and Donald M Lambert Laboratory of Myeloma Genetics, Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Blood 99:1745-57. 2002
    Bone marrow plasma cells (PCs) from 74 patients with newly diagnosed multiple myeloma (MM), 5 with monoclonal gammopathy of undetermined significance (MGUS), and 31 healthy volunteers (normal PCs) were purified by CD138(+) selection...
  88. ncbi CD19-CD45 low/- CD38 high/CD138+ plasma cells enrich for human tumorigenic myeloma cells
    D Kim
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Leukemia 26:2530-7. 2012
    Multiple myeloma is a hematological neoplasm characterized by the accumulation of clonal plasma cells in the bone marrow...
  89. ncbi Sclerostin is overexpressed by plasma cells from multiple myeloma patients
    Giacomina Brunetti
    Department of Basic Medical Science, Section of Human Anatomy and Histology, University of Bari, Bari, Italy
    Ann N Y Acad Sci 1237:19-23. 2011
    ..We provide evidence that sclerostin is expressed by myeloma cells that are human myeloma cell lines and plasma cells (CD138(+) cells) obtained from the bone marrow (BM) of a large number of MM patients with bone disease...
  90. pmc Plasmacytoid dendritic cells inhibit pulmonary immunopathology and promote clearance of respiratory syncytial virus
    Joost J Smit
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Exp Med 203:1153-9. 2006
    ..It is demonstrated that plasmacytoid dendritic cells play a protective role during RSV infection by modulation of local immune responses...
  91. ncbi MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation
    Naoyuki Fujita
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cell 119:75-86. 2004
    ..cell fate during the germinal center reaction by preventing terminal differentiation of B lymphocytes into plasma cells until appropriate signals are received...
  92. ncbi IgE⁺ memory B cells and plasma cells generated through a germinal-center pathway
    Oezcan Talay
    Department of Immunology, Genentech, South San Francisco, California, USA
    Nat Immunol 13:396-404. 2012
    ..and memory, we found that IgE(+) cells developed through a germinal-center IgE(+) intermediate to form IgE(+) memory B cells and plasma cells. Our studies delineate a new model for the in vivo biology of IgE switching and memory.
  93. ncbi Plasma cells require autophagy for sustainable immunoglobulin production
    Niccolò Pengo
    Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy
    Nat Immunol 14:298-305. 2013
    The role of autophagy in plasma cells is unknown...
  94. ncbi Immunization induces activation of bone marrow eosinophils required for plasma cell survival
    Van T Chu
    Deutsches Rheuma ForschungsZentrum, Institut der Leibniz Gemeinschaft, Berlin, Germany
    Eur J Immunol 42:130-7. 2012
    ..producers of cytokines required for plasma cell survival, they are essential for the long-term maintenance of plasma cells in the BM...
  95. ncbi CD138-negative clonogenic cells are plasma cells but not B cells in some multiple myeloma patients
    N Hosen
    Department of Cancer Stem Cell Biology, Osaka, Japan
    Leukemia 26:2135-41. 2012
    ..However, it is unclear whether CD138-negative clonogenic MM plasma cells are identical to clonotypic CD19(+) B cells...
  96. pmc Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells
    Mohammed Ata Ur Rasheed
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA
    J Virol 87:7737-46. 2013
    Long-lived plasma cells that reside in the bone marrow constitutively produce antibody in the absence of antigen and are the cellular basis of durable humoral immunity...
  97. pmc B cell homeostasis and plasma cell homing controlled by Krüppel-like factor 2
    Rebecca Winkelmann
    Division of Molecular Immunology, Nikolaus Fiebiger Center, Department of Internal Medicine III, Friedrich Alexander University Erlangen Nurnberg, D 91054 Erlangen, Germany
    Proc Natl Acad Sci U S A 108:710-5. 2011
    ..Instead, KLF2 controls homeostasis of B cells in peripheral lymphatic organs and homing of plasma cells to the bone marrow, presumably by controlling the expression of β(7)-integrin...
  98. ncbi Stromal niches, plasma cell differentiation and survival
    Katrin Moser
    Department for Humoral Immunology, German Arthritis Research Centre, Berlin, Schumannstrasse 21 22, D 10117 Berlin, Germany
    Curr Opin Immunol 18:265-70. 2006
    ..Relocation does not apply to long-lived plasma cells responsible for sustained titers of high-affinity systemic antibody...
  99. pmc CXCR3-dependent plasma blast migration to the central nervous system during viral encephalomyelitis
    Cristina P Marques
    Department of Neuroscience, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, NC30, Cleveland, OH 44195, USA
    J Virol 85:6136-47. 2011
    ..These results demonstrate that CXCR3 ligands are indispensable for recruitment of activated ASC into the inflamed CNS and highlight their local protective role during persistent infection...
  100. ncbi Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help
    Hendrik Poeck
    Department of Internal Medicine, Division of Clinical Pharmacology, Ludwig Maximilians University of Munich, Germany
    Blood 103:3058-64. 2004
    ..This stimulation protocol was sufficient to drive purified naive B cells into IgM-producing plasma cells and to trigger IgG synthesis in memory B cells. PDCs contributed to B-cell activation via IFN-alpha secretion...
  101. ncbi Staying alive: regulation of plasma cell survival
    Stuart G Tangye
    Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Trends Immunol 32:595-602. 2011
    ..This protection is largely mediated by plasma cells (PCs) that produce copious quantities of antibodies for extended periods of time, even after pathogen clearance...

Research Grants81

  1. MHC Class II Transactivator Function and Regulation
    JEREMY BOSS; Fiscal Year: 2009
    ..to determine the mechanism of CIITA gene silencing that occurs as germinal center B cells differentiate into plasma cells. Our data indicate that gene silencing occurs at the level of the local chromatin structure and is mediated by ..
  2. Cellular &Molecular Defects in Human B Cell Development
    Charlotte Cunningham-Rundles; Fiscal Year: 2013
    ..somatic hyper-mutation and isotype switch, secrete immune globulins poorly, and fail to differentiate into plasma cells. The genetic causes of B cell dysfunction in CVID are largely unknown...
  3. Twenty-second Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2010
    ..abnormalities of FA genes and FA gene expression have been reported in patients with sporadic malignancies of plasma cells, leukemia, head and neck cancer, lung cancer, and ovarian cancer...
  4. 24th Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2012
    ..Acquired abnormalities of FA genes and FA gene expression have been reported in patients with sporadic malignancies of plasma cells, leukemia, head and neck cancer, lung cancer, and ovarian cancer.
  5. Epigenetic downregulation of the antibody response and inhibition of autoimmunity
    Paolo Casali; Fiscal Year: 2013
    ..mutated and class-switched (mainly IgG) autoantibodies to nuclear antigens, as secreted by large numbers of plasma cells, produce widespread tissue and organ injury...
  6. SCHISTOSOME EGG INDUCED TH2 RESPONSES
    Edward J Pearce; Fiscal Year: 2013
    ..and B cell responses over time during infection, incorporating a detailed study of Th2 cells, Tfh cells and plasma cells. We will ask whether both Th2 and Tfh responses are modulated over time, and whether increasing the relative ..
  7. Mucosal Immunity and Influenza Vaccines: Phenotype and Role of Activated B Cells
    HARRY BERNARD GREENBERG; Fiscal Year: 2010
    ..and older children already have a varying number of previous exposures to influenza, resulting in long-life plasma cells and circulating antibodies with variable cross-reactivity to the current influenza vaccine...
  8. Autoimmunity Center of Excellence - Rochester
    R John Looney; Fiscal Year: 2013
    ..shown to be very active in a mouse model of SLE, and is able to induce apoptosis of both short- and long-lived plasma cells. In addition, we have preliminary data that bortezomib can block alpha interferon production by plasmacytoid ..
  9. Gene-Engineered and Targeted Stem Cell Therapy for Myeloma
    Selvarangan Ponnazhagan; Fiscal Year: 2013
    ..HEALTH RELEVANCE: Multiple myeloma is a B-cell malignancy characterized by the infiltration and growth of plasma cells in the bone marrow...
  10. Twenty-first Annual Fanconi Anemia Research Fund Scientific Symposium
    Grover Bagby; Fiscal Year: 2009
    ..Acquired abnormalities of FA genes and FA gene expression have been reported in patients with sporadic malignancies of plasma cells, leukemia, head and neck cancer, lung cancer, and ovarian cancer.
  11. A Fourth Outcome: DNA Damage and the Differentiation of B Cells
    Michael A Teitell; Fiscal Year: 2013
    ..and remodeling of immunoglobulin (IG) genes within germinal centers (GCs) to generate memory B and plasma cells. Unfortunately, genotoxic stress associated with the GC reaction also promotes most B cell malignancies...
  12. Immune Regulation of CNS Viral Recrudescence
    Cornelia Bergmann; Fiscal Year: 2010
    ..infections, ASC preferentially migrate to bone marrow (BM), where they differentiate into long lived sessile plasma cells (PC) dedicated to immunoglobubulin (Ig) secretion...
  13. N-Glycosylation And ER Stress
    MARK LEHRMAN; Fiscal Year: 2012
    ..the ER stress response, which governs the productivity of the ER, is essential for the secretory functions of plasma cells (immunoglobulins) and pancreatic islets (insulin), and when aberrantly controlled can cause neurological ..
  14. Antibody Mediated Autoimmunity in Neuromyelitis Optica
    HANS CHRISTIAN VON BUEDINGEN; Fiscal Year: 2013
    ..recombinant monoclonal antibodies (rAbs) generated from CSF plasma cells, and by b.) purified soluble immunoglobulins from serum and CSF from anti- AQP4 seropositive NMO patients...
  15. Genome Wide Admixture Scan for Multiple Myeloma in African Americans
    CHRISTOPHER ALAN HAIMAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Multiple myeloma (MM) is a malignancy consisting of a neoplastic clone of plasma cells, the terminally-differentiated B lymphocytes responsible for antibody production...
  16. Long-lived B cell Immunity in the Respiratory Tract
    Nicole Baumgarth; Fiscal Year: 2013
    ..They will assess the extent to which migration of virus-specific B cells/plasma cells from regional lymph nodes is required for the establishment of lung tissue plasma cell pools, and using genetic ..
  17. Molecular Mechanisms and Treatment of Primary Amyloid AL Cardiomyopathy
    Ronglih Liao; Fiscal Year: 2013
    ..systemic amyloidosis and is initiated by the clonal production of immunoglobulin light chain (LC) proteins by plasma cells. While AL aggregates may form in numerous organs, cardiac deposition is associated with the worst prognosis...
  18. CRTC2 in Cellular Development, Function, and Neoplasia
    Michael A Teitell; Fiscal Year: 2013
    ..undergo rapid proliferation and remodeling of immunoglobulin (IG) genes within GCs to generate memory B and plasma cells. Unfortunately, DNA damage associated with this "GC reaction" also promotes most B cell malignancies...
  19. Id3/B Lymphocytes and Atherosclerosis
    Coleen A McNamara; Fiscal Year: 2010
    ..12. B cells and plasma cells have been demonstrated in both the intima of plaques as well as in the adventitia of humans and animals7 " 13-..
  20. IL-15 Superagonist Complex as an Immunotherapeutic for Multiple Myeloma
    Hing C Wong; Fiscal Year: 2012
    ..MM is a malignancy of clonal plasma cells in the bone marrow (BM) characterized by the presence of paraproteinemia, destructive bone disease, ..
  21. A Mouse Model for the Rare Plasma Cell Disease AL Amyloidosis
    David C Seldin; Fiscal Year: 2010
    ..AL is a disease with features of a plasma cell dyscrasia, and is caused by a low grade clonal expansion of plasma cells in the bone marrow...
  22. Quantitative Mass Spectrometry Assays to Detect Multiple Myeloma and Assess Relap
    JOHN MATTHEW KOOMEN; Fiscal Year: 2010
    ..In myeloma, malignant plasma cells proliferate in the bone marrow, creating several symptoms in the patient...
  23. The Role of Intrathecal Plasma Cell Clones in MS Pathogenesis
    GREGORY PARKS OWENS; Fiscal Year: 2013
    ..to efficiently amplify the heavy (VH) and light (VL) chain variable regions expressed by sorted MS CSF CD138+ plasma cells. Repertoires generated from CD138+ cells of MS patients each displayed seminal features of a T cell-dependent, ..
  24. Humoral responses to Lyme Borreliosis: A mouse model
    Nicole Baumgarth; Fiscal Year: 2012
    ..findings, we aim to test the hypothesis that Bb- specific B cells provide antibody responses by short-lived plasma cells at the expense of higher affinity B cells and long-lived plasma cells due to a lack of functional CD4 helper T ..
  25. Genetic Regulation of B Lymphocyte Aortic Homing and Atheroprotection
    Coleen A McNamara; Fiscal Year: 2013
    ..B cells and plasma cells have been identified in plaque and adventitia in humans and animal models of atherosclerosis throughout the ..
  26. Manipulation of Follicular Helper T Cells in Immunity and Autoimmunity
    Joseph Craft; Fiscal Year: 2013
    ....
  27. Elucidating the role of microRNAs in the initiation of multiple myeloma
    Jianjun Zhao; Fiscal Year: 2013
    ..provided by applicant): Multiple myeloma (MM) is a cancer characterized by colonial proliferation of plasma cells in bone marrow, lytic bone lesions, and serum monoclonal gammopathy...
  28. Mucosal Immune Ontogeny and Intestinal Microbiota in Infants
    Edward N Janoff; Fiscal Year: 2010
    ..Therefore, we hypothesize that: 1) The number of T and B lymphocytes and plasma cells will increase in number in the lamina propria of infants from birth to 2 years of age...
  29. Immunotherapeutic HPV cancer vaccines that target Langerhans cells
    Gerard Zurawski; Fiscal Year: 2010
    ..IntDCs induce the differentiation of naove B cells into immunoglobulin-secreting plasma cells. In contrast, LCs are particularly efficient inducers/activators of cytotoxic CD8+ T lymphocytes (CTLs), the ..
  30. Phase 1 of AR-42 in relapsed CLL, lymphoma, myeloma
    Craig C Hofmeister; Fiscal Year: 2012
    ..for AR-42 and potentially other DAC inhibitors;2c) Changes in the microRNA and mRNA signature of CD138+ plasma cells of myeloma patients after exposure to AR-42 using high-throughput microRNA/gene expression analysis Nano-String ..
  31. Transcriptional Functions and Targets of the MMSET Protein of t(4:14) Myeloma
    Jonathan Licht; Fiscal Year: 2013
    Multiple myeloma (MM) represents the malignant transformation of plasma cells, differentiated, post-germinal center B-cells adapted for the production of large quantities of antibody...
  32. PATHOGENESIS OF AUTOANTIBODIES IN PRISTANE-INDUCED LUPUS
    Westley H Reeves; Fiscal Year: 2013
    ..mechanism(s) by which anti-Sm/RNP memory B cells undergo terminal differentiation into autoantibody-secreting plasma cells. The overall objective is to develop a strategy to selectively block IFN-I and autoantibody production...
  33. Role of B-cells and CNS antibodies in modulating chronic microglial activation
    James R Lokensgard; Fiscal Year: 2013
    ..MCMV) model of viral brain infection, we were surprised to detect numerous CD19(-)CD38(+)CD138(+) plasma cells and CD19(+)CD1d(high)CD5(+) regulatory B-cells (Breg) persisting in the CNS during chronic infection...
  34. Regulation of antibody diversification and production in HIV-1 infection
    Andrea Cerutti; Fiscal Year: 2012
    ..Ultimately, GC B cells differentiate into plasma cells, which secrete large amounts of IgG and IgA antibodies...
  35. Inhibitors of IgH Gene Enhancers for the Treatment of Multiple Myeloma
    FRANK W MARCOUX; Fiscal Year: 2013
    ..strategy that targets a singular, key genetic mechanism that is responsible for the transformation of normal plasma cells - ImmunoGlobulin Heavy chain (IgH) gene translocations...
  36. Regulation of effector T cell function by Blimp-1 in a murine model of colitis
    GISLAINE APARECIDA MARTINS; Fiscal Year: 2010
    ..Blimp-1 was first known for its crucial role in the terminal differentiation of antibody-secreting plasma cells. Recent studies show that Blimp-1 is also highly expressed in activated T cells...
  37. GLUCOCORTICOSTEROID ACTION IN INFLAMMATORY DISEASE
    Robert P Schleimer; Fiscal Year: 2013
    ..We will determine whether treatment with prednisone diminishes the local presence of B cells, plasma cells, and these cytokines and immunoglobulins...
  38. Defining the mechanisms of secretion in the Drosophila salivary gland
    REBECCA MARIE FOX; Fiscal Year: 2010
    ..For example, in the immune system, B-cells differentiate into plasma cells by up-regulating the secretory machinery, thereby acquiring the ability to secrete large amounts of antibodies ..
  39. CD38 Pretargeted Radioimmunotherapy for Myeloma
    Oliver W Press; Fiscal Year: 2013
    ..and therapeutic efficacy of radiolabeled DOTA-biotin targeted to mouse myeloma xenografts;and malignant plasma cells in the SCID-hu mouse myeloma model...
  40. Radiovirotherapy for Multiple Myeloma
    Stephen J Russell; Fiscal Year: 2012
    ..MV-NIS is a recombinant measles virus that targets myeloma plasma cells and codes for the human thyroidal sodium iodide symporter, NIS...
  41. Overcoming established anaphylactic hypersensitivity to peanuts
    Kelvin P Lee; Fiscal Year: 2013
    ..immunity following vaccination requires continuous Ag-independent immunoglobulin production by long lived plasma cells (LLPC) that can survive for decades/lifetime in specific bone marrow (BM) niches...
  42. CD28-mediated Regulation of Multiple Myeloma Cell Proliferation and Survival
    Kelvin P Lee; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Multiple myeloma (MM) is a neoplasm of bone marrow (BM) resident plasma cells (PC) that comprises 20% of all hematologic malignancies, and despite new chemotherapeutic agents remains incurable...
  43. The role of ADAM10 in B cell development and humoral immunity
    NATALIA SOL CHAIMOWITZ; Fiscal Year: 2013
    ..of ADAM10 in somatic hypermutation, mice will be immunized with NP- KLH in alum and germinal center B cell and plasma cells will be sorted. DNA will be isolated and 186.2 V regions will be amplified by nested PCR...
  44. Genetic Basis of Non-Familial IgA Nephropathy
    Tongzhong Ju; Fiscal Year: 2012
    ..we will focus on three Aims for this proposal: 1) Examine Cosmc gene in Tn(+), IgA1 secreting B cells or plasma cells isolated from patients with IgAN and matched healthy controls;examine the Cosmc gene from immortalized Tn(+), ..
  45. Proteosome inhibitor sensitivity in multiple myeloma: The role of ER stress
    Lawrence H Boise; Fiscal Year: 2012
    Multiple myeloma is a neoplasia of plasma cells in the bone marrow and is presently an incurable disease...
  46. Nontoxic Strategies to Establish Allochimerism in Mice
    Bruce R Blazar; Fiscal Year: 2012
    ..at the time of BMT, long-lived antibody-secreting cells must be generated with the most likely candidates being plasma cells. Although much is known about Ab response to foreign antigens (Ags), the mechanisms responsible for alloAb ..
  47. The role of miRNA15a and 16-1 in Multiple Myeloma
    Irene M Ghobrial; Fiscal Year: 2013
    ..One possible explanation for the changes that occur in normal plasma cells that lead to proliferation into malignant MM cells is epigenetic alterations, such as the regulation of micro-..
  48. The Role of NF-kB in B-Cell Differentiation and Lymphomagenesis
    Ulf Klein; Fiscal Year: 2013
    ..mature B cells that have undergone the germinal center (GC) reaction to generate memory B cells and plasma cells, and the development of several lymphoma subtypes has been linked to the oncogenic transformation of the ..
  49. In vivo imaging of T and B cell interactions in germinal center initiation
    Ann M Haberman; Fiscal Year: 2012
    ..vaccines critically depends on the formation of germinal centers (GC) to form high affinity memory B cells and plasma cells. Despite the importance of GCs in T cell dependent immune responses, fundamental aspects of GC dynamics remain ..
  50. Myeloma-Microenvironment Interaction Dynamics
    Shmuel Yaccoby; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Myeloma is characterized by the accumulation of malignant plasma cells in the bone marrow and is accompanied by severe bone disease...
  51. Studies in pig-to-primate cardiac xenotransplantation
    CHRISTOPHER G A MC GREGOR; Fiscal Year: 2013
    ..be used to remove preformed non-Gal antibody (PNGA) and the proteasome inhibitor Bortezomib given to delete plasma cells prior to OCXTx...
  52. The Role of B Cell Maturation Antigen in Controlling Tolerance
    CHRISTINE MOREL COQUERY; Fiscal Year: 2013
    ..by applicant): The Role of B Cell Maturation Antigen in Controlling Tolerance The establishment of long-lived plasma cells (PC) is a hallmark of the adaptive immune response and is critical for host protection against pathogens...
  53. Discovery of Novel Autoantigens in Patients with Inclusion Body Myositis
    KEVIN C O'CONNOR; Fiscal Year: 2013
    ..We have determined that previously unappreciated components of the immune system, namely antibody-secreting plasma cells, infiltrate the muscle tissue in this disease...
  54. Excessive Receptor Editing and Generation of Autoreactive Antibodies in SLE
    Zhixin Zhang; Fiscal Year: 2012
    ..Our initial analyses of 193 IgH genes derived from SLE plasma cells and naove B cells revealed many features of autoantibodies, such as long CDR3 regions with multiple positively ..
  55. Rotator cuff repair using hyaluronan enriched fascia extracellular matrix
    KATHLEEN ANNE DERWIN; Fiscal Year: 2013
    ..of engineered fascia to modulate chronic inflammation, as defined by the number of persisting lymphocytes and plasma cells, will be quantified in a rat abdominal wall defect model...
  56. Ancillary Studies in Clinical Trials - PRIMeR
    Marcelo C Pasquini; Fiscal Year: 2013
    ..use a comprehensive 7-color panel of plasma cell markers to differentiate between normal and abnormal (myeloma) plasma cells in about 470 patients who are enrolled in the STaMINA clinical trial from December 2010 to June 2013...
  57. Role of Memory T Cells in Pathogenesis and Resolution of Inflammatory Diseases
    Richard B Bankert; Fiscal Year: 2010
    ..fibrosis and by the infiltration of inflammatory cells including eosinophils, neutrophils, macrophages, plasma cells and lymphocytes...
  58. Chronic Antibody-Mediated Injury in Renal Allografts
    Mark D Stegall; Fiscal Year: 2011
    ..In our Preliminary Data, we show that the proteasome inhibitor, bortezomib, depletes alloantibody-secreting plasma cells resulting in lower serum DSA levels...
  59. Inhibition of interleukin-6 production for the treatment of multiple myeloma
    Jetze J Tepe; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Multiple myeloma (MM) is a malignant disorder of differentiated B-cells (plasma cells) and remains incurable...
  60. Durable humoral immunity regulated by intrinsic CD28 function in plasma cells
    Kelvin P Lee; Fiscal Year: 2013
    ..paradigm is this occurs via continuous antigen-independent antibody production by a subset of long-lived plasma cells (LLPC) that survive within a limited number of specific niches in the bone marrow (BM)...
  61. A Translational Model of Evolution of Myeloma Adhesion-Mediated Drug Resistance
    Ariosto S Silva; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Multiple Myeloma (MM) is an incurable disease in which malignant plasma cells proliferate excessively in the bone marrow (BM)...
  62. Regulation of humoral immunity by NKT cells
    Mark L Lang; Fiscal Year: 2013
    ..responses by stimulating the immune system to maintain Ag-specific memory B cells and long-lived Ab-secreting plasma cells. In order to develop more effective Ab-stimulating vaccines in future, we need to improve our understanding of ..
  63. REGULATION OF PLASMA CELL MALIGNANCY BY INSULIN AND IGF
    GREGORY FREUND; Fiscal Year: 2000
    DESCRIPTION (Applicant's Description): Multiple myeloma is a malignant proliferation of plasma cells, and, as with all cancers, it is critical to understand the factors which promote its metabolism, growth and death...
  64. Treatment decision making in older adults newly diagnosed with multiple myeloma
    Joseph D Tariman; Fiscal Year: 2010
    ..PROBLEM: Multiple myeloma is a B-cell malignancy of the plasma cells primarily affecting older adults with median age of diagnosis at 65...
  65. PERIODONTAL DISEASES: B CELLS ACTIVATED BY MITOGENS
    JAMES CLAGETT; Fiscal Year: 1980
    ..S. In advanced periodontal lesions, plasma cells are the predominant cell type observed yet the origin and the role of these cells in the pathogenesis of the ..
  66. From Unfolded Proteins in the ER to Disease
    Linda Hendershot; Fiscal Year: 2009
    ..Finally, many highly differentiated cell types, such as pancreatic beta cells and plasma cells, require signaling pathways to properly coordinate protein expression and secretion with the ER protein folding ..
  67. DEVELOPMENT OF THE SECRETORY IMMUNE SYSTEM
    Albert Jones; Fiscal Year: 1991
    ..The structures under study are Peyer's patches, M-cells, plasma cells, intestinal epithelial cells, and liver cells...
  68. Psychological stress, cortisol, and B lymphocyte decrements
    Bonnie McGregor; Fiscal Year: 2007
    ..events that involve a variety of immune cells and ultimately result in the production of antibodies by mature plasma cells of the B lymphocyte lineage...
  69. NOVEL SEROTHERAPY STRATEGIES--PLASMA CELL MALIGNANCIES
    STEVEN TREON; Fiscal Year: 2004
    ..These efforts have focused on Muc-1 core protein, a tumor selective antigen found on most MM plasma cells, and CD20, a B- cell specific antigen found on the plasma cells of most WM patients (75-100 percent), and ..
  70. A Novel Antibody Therapeutic for Multiple Myeloma
    Koteswara Chintalacharuvu; Fiscal Year: 2009
    Multiple myeloma is an incurable monoclonal proliferative disorder of malignant plasma cells affecting more than 14,000 persons in the U.S.A. per year...
  71. GLUCOCORTICOSTEROID ACTION IN INFLAMMATORY DISEASE
    Robert Schleimer; Fiscal Year: 2009
    ..We will determine whether treatment with prednisone diminishes the local presence of B cells, plasma cells, and these cytokines and immunoglobulins...
  72. Curcumin/Bioperine in Multiple Myeloma
    Saroj Vadhan Raj; Fiscal Year: 2005
    ..Multiple myeloma is a clonal malignancy of plasma cells, affecting 13,000 of Americans each year...
  73. ANTIGEN ABSORPTION AND B CELL RESPONSE IN GUT
    DALE BOCKMAN; Fiscal Year: 1980
    ..and lymphcytes of Peyer's patches, appendix, and bursa of Fabricius in antigen absorption and production of plasma cells will be explored...
  74. TERTIARY LYMPHOID ORGANS IN TYPE I DIABETES MELLITUS
    NANCY RUDDLE; Fiscal Year: 2003
    ..with the morphologic and antigenic (MAdCAM-1 and PNAd) characteristics of high endothelial venules (HEV), and plasma cells secreting specific IgG after immunization...
  75. CDK Inhibitor and B Cell Terminal Differentiation
    Selina Chen Kiang; Fiscal Year: 2006
    ..kinase (CDK) inhibitors control cell cycle progression and cellular differentiation in the generation of plasma cells. In humoral immunity, the generation of a primary antibody response requires activation and expansion of ..
  76. Polyadenylation Factors in B-Cells, Lymphoma & Myeloma
    Christine Milcarek; Fiscal Year: 2007
    ..AIM 3. We will test the hypothesis that over-expression of hnRNP F in authentic plasma cells will suppress Ig heavy chain secretion by reducing the amount of secretory specific mRNA. AIM 4...
  77. Endothelial Progenitor Cells in Multiple Myeloma
    Olcay Batuman; Fiscal Year: 2006
    ..accounts for 1% of cancers and 2% of cancer deaths, is a liquid tumor characterized by expansion of monoclonal plasma cells and immunoglobulin (M protein) secretion...
  78. CELLULAR AND MOLECULAR EVENTS IN B LYMPHOCYTE ACTIVATION
    RONALD CORLEY; Fiscal Year: 2001
    ..The overall goals of these experiments are to characterize the secretory compartment in plasma cells and define the proteins and structures that determine the specificity of constitutive vesicular trafficking ..
  79. B Cell Tolerance Following Allograft Transplantation
    Anita Chong; Fiscal Year: 2005
    ..test whether clonal deletion, inappropriate homing, inhibition of proliferation or lack of differentiation into plasma cells are the bases for the control of alloantibody production...
  80. B Cell Repertoire and B cell Neoplasms in Old Mice
    MARC WEKSLER; Fiscal Year: 2006
    ..to the appearance of antigen-specific serum monoclonal immunoglobulin (mlg) and antigen-specific clonal BM plasma cells after the appearance of antigen-specific mlg or diffuse large cell lymphoma (DLCL) from DNP-human serum albumin ..
  81. INHIBITION OF IL-6 AND STAT3 IN RHEUMATOID ARTHRITIS
    Lionel Ivashkiv; Fiscal Year: 1999
    ..process that is characterized by the presence of activated monocytes/macrophages, T cells, B cells, plasma cells, and synovial fibroblasts in inflamed joints...