b lymphocytes

Summary

Summary: Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.

Top Publications

  1. ncbi Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
    Elizabeth A Leadbetter
    Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Nature 416:603-7. 2002
  2. ncbi Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    Y R Zou
    Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York 10016, USA
    Nature 393:595-9. 1998
  3. doi Systemic lupus erythematosus
    Anisur Rahman
    Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom
    N Engl J Med 358:929-39. 2008
  4. ncbi A chemokine-driven positive feedback loop organizes lymphoid follicles
    K M Ansel
    Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    Nature 406:309-14. 2000
  5. ncbi The B7-CD28 superfamily
    Arlene H Sharpe
    Immunology Research Division, Department of Pathology, Brigham, and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 2:116-26. 2002
  6. ncbi Plasma cell differentiation requires the transcription factor XBP-1
    A M Reimold
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 412:300-7. 2001
  7. ncbi Predominant autoantibody production by early human B cell precursors
    Hedda Wardemann
    Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10021, USA
    Science 301:1374-7. 2003
  8. ncbi The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
  9. doi B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
    Stephen L Hauser
    Department of Neurology, University of California at San Francisco, San Francisco, CA 94143 0114, USA
    N Engl J Med 358:676-88. 2008
  10. ncbi CpG motifs in bacterial DNA and their immune effects
    Arthur M Krieg
    Department of Veterans Affairs Medical Center, Iowa City, Iowa 52246, USA
    Annu Rev Immunol 20:709-60. 2002

Detail Information

Publications331 found, 100 shown here

  1. ncbi Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
    Elizabeth A Leadbetter
    Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Nature 416:603-7. 2002
    ..The unique features of this dual-engagement pathway should facilitate the development of therapies that specifically target autoreactive B cells...
  2. ncbi Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    Y R Zou
    Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York 10016, USA
    Nature 393:595-9. 1998
    ..These results may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia...
  3. doi Systemic lupus erythematosus
    Anisur Rahman
    Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom
    N Engl J Med 358:929-39. 2008
  4. ncbi A chemokine-driven positive feedback loop organizes lymphoid follicles
    K M Ansel
    Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    Nature 406:309-14. 2000
    ..In germinal centres the feedback loop is overridden, with B-cell lymphotoxin alpha1beta2 expression being induced by a mechanism independent of BLC...
  5. ncbi The B7-CD28 superfamily
    Arlene H Sharpe
    Immunology Research Division, Department of Pathology, Brigham, and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 2:116-26. 2002
    ..Here, we summarize our current understanding of the new members of the B7 and CD28 families, and discuss their therapeutic potential...
  6. ncbi Plasma cell differentiation requires the transcription factor XBP-1
    A M Reimold
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 412:300-7. 2001
    ..Mouse lymphoid chimaeras deficient in XBP-1 possessed normal numbers of activated B lymphocytes that proliferated, secreted cytokines and formed normal germinal centres...
  7. ncbi Predominant autoantibody production by early human B cell precursors
    Hedda Wardemann
    Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10021, USA
    Science 301:1374-7. 2003
    ..Most of these autoantibodies were removed from the population at two discrete checkpoints during B cell development. Inefficient checkpoint regulation would lead to substantial increases in circulating autoantibodies...
  8. ncbi The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
    ..We examined the evolution of the pathological effects of airway obstruction in patients with COPD...
  9. doi B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
    Stephen L Hauser
    Department of Neurology, University of California at San Francisco, San Francisco, CA 94143 0114, USA
    N Engl J Med 358:676-88. 2008
    There is increasing evidence that B lymphocytes are involved in the pathogenesis of multiple sclerosis, and they may be a therapeutic target. Rituximab, a monoclonal antibody, selectively targets and depletes CD20+ B lymphocytes.
  10. ncbi CpG motifs in bacterial DNA and their immune effects
    Arthur M Krieg
    Department of Veterans Affairs Medical Center, Iowa City, Iowa 52246, USA
    Annu Rev Immunol 20:709-60. 2002
    ..CpG ODN also enhance the development of acquired immune responses for prophylactic and therapeutic vaccination...
  11. ncbi Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination
    Ulf Klein
    Institute for Cancer Genetics, Department of Pathology and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA
    Nat Immunol 7:773-82. 2006
    ..These results identify IRF4 as a crucial transcriptional 'switch' in the generation of functionally competent plasma cells...
  12. ncbi OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    Y Y Kong
    Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Nature 397:315-23. 1999
    ..Although dendritic cells appear normal, opgl-deficient mice exhibit defects in early differentiation of T and B lymphocytes. Surprisingly, opgl-deficient mice lack all lymph nodes but have normal splenic structure and Peyer's patches...
  13. ncbi Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells
    Tobias Junt
    Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 450:110-4. 2007
    ....
  14. ncbi Development of a human adaptive immune system in cord blood cell-transplanted mice
    Elisabetta Traggiai
    Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
    Science 304:104-7. 2004
    ..This provides a valuable model to study development and function of the human adaptive immune system in vivo...
  15. ncbi RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
    Y Shinkai
    Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Cell 68:855-67. 1992
    ..Because the SCID phenotype was the only obvious abnormality detected in RAG-2 mutant mice, RAG-2 function and V(D)J recombinase activity, per se, are not required for development of cells other than lymphocytes...
  16. ncbi Control of B-cell responses by Toll-like receptors
    Chandrashekhar Pasare
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, 300 Cedar Street New Haven, Connecticut 06510, USA
    Nature 438:364-8. 2005
    ..We find that, in addition to CD4+ T-cell help, generation of T-dependent antigen-specific antibody responses requires activation of TLRs in B cells...
  17. ncbi CD40-CD40 ligand
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    J Leukoc Biol 67:2-17. 2000
    ..to the tumor necrosis factor-R (TNF-R) family, and that was first identified and functionally characterized on B lymphocytes. Its critical role in T cell-dependent humoral immune responses was demonstrated by patients with the hyper-..
  18. ncbi Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase
    H Suzuki
    Department of Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Science 283:390-2. 1999
    ..These results provide evidence that p85alpha is functionally linked to the Btk pathway in antigen receptor-mediated signal transduction and is pivotal in B cell development and functions...
  19. ncbi A critical role for IL-21 in regulating immunoglobulin production
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Science 298:1630-4. 2002
    ..This suggests that these gammac-dependent cytokines may be those whose inactivation is primarily responsible for the B cell defect in humans with XSCID...
  20. pmc Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    D Breitfeld
    Molecular Tumor and Immunogenetics, Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    J Exp Med 192:1545-52. 2000
    ..Based on the characteristic localization within secondary lymphoid organs, we suggest to term these cells "follicular B helper T cells" (T(FH))...
  21. pmc Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency
    Jacob Hanna
    The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 133:250-64. 2008
    ..and inducible expression of four transcription factors (Oct4, Sox2, Klf4, and c-Myc) to reprogram mouse B lymphocytes. These factors were sufficient to convert nonterminally differentiated B cells to a pluripotent state...
  22. ncbi Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
    Neal N Iwakoshi
    Department of Immunology and Infectious Diseases, Harvard School of Public Health 651 Huntington Avenue, Boston, Massachusetts 02115 6017, USA
    Nat Immunol 4:321-9. 2003
    ..We also show that XBP-1 is involved in controlling the production of interleukin-6, a cytokine that is essential for plasma cell survival. Thus, signals upstream and downstream of XBP-1 integrate plasma cell differentiation with the UPR...
  23. ncbi Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    L Alexopoulou
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Nature 413:732-8. 2001
    ..Moreover, poly(I:C) can induce activation of NF-kappaB and mitogen-activated protein (MAP) kinases independently of MyD88, and cause dendritic cells to mature...
  24. ncbi Interleukin-10-deficient mice develop chronic enterocolitis
    R Kuhn
    Institute for Genetics, University of Cologne, Federal Republic of Germany
    Cell 75:263-74. 1993
    ..These results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract...
  25. pmc CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    P Schaerli
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Exp Med 192:1553-62. 2000
    ..These properties portray CXCR5(+) T cells as a distinct memory T cell subset with B cell helper function, designated here as follicular B helper T cells (T(FH))...
  26. ncbi Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
    J Parrish-Novak
    Department of Functional Cloning, ZymoGenetics, Inc, Seattle, Washington 98102, USA
    Nature 408:57-63. 2000
    ....
  27. ncbi Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication
    Prapaporn Pisitkun
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases NIAID, NIH, Rockville, MD 20852, USA
    Science 312:1669-72. 2006
    ..These results reveal high divergence in mouse Y chromosomes and represent a good example of gene copy number qualitatively altering a polygenic disease manifestation...
  28. ncbi B cells regulate autoimmunity by provision of IL-10
    Simon Fillatreau
    University of Edinburgh, Institute of Cell, Animal and Population Biology, King s Buildings West Mains Road, Edinburgh EH9 3JT, UK
    Nat Immunol 3:944-50. 2002
    ..In the absence of IL-10 production by B cells, the pro-inflammatory type 1 immune response persisted and mice did not recover. These data show that B cell-derived IL-10 plays a key role in controlling autoimmunity...
  29. ncbi Antigen-specific memory B cell development
    Louise J McHeyzer-Williams
    The Scripps Research Institute, Department of Immunology, La Jolla, CA 92037, USA
    Annu Rev Immunol 23:487-513. 2005
    ..We review the cellular and molecular regulators of this dynamic process with emphasis on the multiple memory B cell fates that develop in vivo...
  30. pmc Follicular helper T cells are required for systemic autoimmunity
    Michelle A Linterman
    Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    J Exp Med 206:561-76. 2009
    ..In contrast, adoptive transfer of sanroque T(FH) cells led to spontaneous GC formation. These findings identify T(FH) dysfunction within GCs and aberrant positive selection as a pathway to systemic autoimmunity...
  31. ncbi Regulation of the germinal center response by microRNA-155
    To Ha Thai
    CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Science 316:604-8. 2007
    ..miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo...
  32. ncbi CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
    R Forster
    Molecular Tumorgenetics and Immunogenetics, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Cell 99:23-33. 1999
    ..Thus, in order to bring together lymphocytes and dendritic cells to form the characteristic microarchitecture of secondary lymphoid organs, CCR7 is required to rapidly initiate an adoptive immune response...
  33. ncbi IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
    Rachel Ettinger
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
    J Immunol 175:7867-79. 2005
    ..Taken together, our data show that IL-21 plays a central role in CSR and plasma cell differentiation during T cell-dependent B cell responses...
  34. pmc IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells
    Irah L King
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 206:1001-7. 2009
    ..Despite the IL-4-mediated link between Th2 cells and B lymphocytes, the location of IL-4-producing T cells in the lymph nodes is currently unclear...
  35. doi Not always the bad guys: B cells as regulators of autoimmune pathology
    Simon Fillatreau
    Simon Fillatreau is at the Immune regulation group, Deutsches Rheuma ForschungsZentrum, Chariteplatz 1, 10117 Berlin, Germany
    Nat Rev Immunol 8:391-7. 2008
    ..According to this model, B cells can translate exposure to certain microbial infections into protection from chronic inflammatory diseases...
  36. doi Regulatory B cells as inhibitors of immune responses and inflammation
    Jean David Bouaziz
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunol Rev 224:201-14. 2008
    ..This review focuses on the recent progress in this field and the exciting opportunities for understanding how this unique B-cell subset influences diverse immune functions...
  37. ncbi An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus
    Elisabetta Traggiai
    Institute for Research in Biomedicine, Via Vela 6, CH 6500 Belllinzona, Switzerland
    Nat Med 10:871-5. 2004
    ..These results show that it is possible to interrogate the memory repertoire of immune donors to rapidly and efficiently isolate neutralizing antibodies that have been selected in the course of natural infection...
  38. ncbi XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation
    A L Shaffer
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Immunity 21:81-93. 2004
    ..Thus, XBP1 coordinates diverse changes in cellular structure and function resulting in the characteristic phenotype of professional secretory cells...
  39. pmc TLR-mediated stimulation of APC: Distinct cytokine responses of B cells and dendritic cells
    Tom A Barr
    Institute of Immunology and Infection Research, School of Biological Science, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 37:3040-53. 2007
    In addition to their role in humoral immunity, B lymphocytes are important antigen-presenting cells (APC). In the same way as other APC, B cells make cytokines upon activation and have the potential to modulate T cell responses...
  40. ncbi Endogenous MHC class II processing of a viral nuclear antigen after autophagy
    Casper Paludan
    Laboratory of Viral Immunobiology, Rockefeller University, New York, NY 10021, USA
    Science 307:593-6. 2005
    ..Thus, lysosomal processing after autophagy may contribute to MHC class II-restricted surveillance of long-lived endogenous antigens including nuclear proteins relevant to disease...
  41. ncbi Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL
    Bing He
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Immunity 26:812-26. 2007
    ..Thus, mucosal vaccines should activate IECs to induce more effective IgA(2) responses...
  42. ncbi Regulation of plasma-cell development
    Miriam Shapiro-Shelef
    Departments of Microbiology, and Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nat Rev Immunol 5:230-42. 2005
    ....
  43. pmc Human polyomavirus JC (JCV) infection of human B lymphocytes: a possible mechanism for JCV transmigration across the blood-brain barrier
    Moti L Chapagain
    Retrovirology Research Laboratory, Department of Tropical Medicine, Medical Microbiology, and Pharmacology, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA
    J Infect Dis 202:184-91. 2010
    ..Moreover, JCV-infected B cells were able to transmit infection to naive glial cells. These data confirm that JCV nonproductively infects B cells and possibly uses them as a vehicle for transmigration across the blood-brain barrier...
  44. ncbi Pax5: the guardian of B cell identity and function
    Cesar Cobaleda
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Immunol 8:463-70. 2007
    ..Conditional Pax5 inactivation in early and late B lymphocytes revealed an essential role for Pax5 in controlling the identity and function of B cells throughout B ..
  45. ncbi A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
    R Forster
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Cell 87:1037-47. 1996
    ..Our results identify the putative chemokine receptor BLR1 as the first G protein-coupled receptor involved in B cell migration and localization of these cells within specific anatomic compartments...
  46. ncbi Organ-specific disease provoked by systemic autoimmunity
    V Kouskoff
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Illkirch, France
    Cell 87:811-22. 1996
    ..We suggest that human RA develops by an analogous mechanism...
  47. pmc Conduits mediate transport of low-molecular-weight antigen to lymph node follicles
    Ramon Roozendaal
    Departments of Pediatrics and Pathology, Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA
    Immunity 30:264-76. 2009
    ..This pathway could be used for enhancing delivery of vaccines or small molecules for improvement of humoral immunity...
  48. ncbi CD95's deadly mission in the immune system
    P H Krammer
    Tumorimmunology Program, German Cancer Research Center, Heidelberg, Germany
    Nature 407:789-95. 2000
    ..Gaining an insight into these processes improves our understanding of the pathogenesis of diseases such as cancer, autoimmunity and AIDS, and opens new approaches to rational treatment strategies...
  49. ncbi Epstein-Barr virus: exploiting the immune system
    D A Thorley-Lawson
    Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Nat Rev Immunol 1:75-82. 2001
    ....
  50. pmc ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context
    Adam A Margolin
    Department of Biomedical Informatics, Columbia University, New York, NY 10032, USA
    BMC Bioinformatics 7:S7. 2006
    ..This method uses an information theoretic approach to eliminate the majority of indirect interactions inferred by co-expression methods...
  51. ncbi RAG-1-deficient mice have no mature B and T lymphocytes
    P Mombaerts
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139
    Cell 68:869-77. 1992
    ..Although RAG-1 expression has been reported in the central nervous system of the mouse, no obvious neuroanatomical or behavioral abnormalities have been found in the RAG-1-deficient mice...
  52. ncbi Duration of humoral immunity to common viral and vaccine antigens
    Ian J Amanna
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    N Engl J Med 357:1903-15. 2007
    ..Maintenance of long-term antibody responses is critical for protective immunity against many pathogens. However, the duration of humoral immunity and the role played by memory B cells remain poorly defined...
  53. ncbi Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells
    Hiroyuki Tezuka
    Department of Immunology, Akita University Graduate School of Medicine, Akita 010 8543, Japan
    Nature 448:929-33. 2007
    ..The presence of a naturally occurring TNF-alpha/iNOS-producing dendritic-cell subset may explain the predominance of IgA production in the MALT, critical for gut homeostasis...
  54. ncbi BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator
    P A Moore
    Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA
    Science 285:260-3. 1999
    ..The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation...
  55. ncbi An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
    B Schiemann
    Biogen, 14 Cambridge Center, Cambridge, MA 02142, USA
    Science 293:2111-4. 2001
    ..lymphoid organs from BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes. In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments...
  56. ncbi Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens
    F Martin
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Immunity 14:617-29. 2001
    ....
  57. ncbi Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function
    H W Mittrucker
    Department of Immunology, University of Toronto, Toronto, Ontario, M5G 2C1, Canada
    Science 275:540-3. 1997
    ..T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes...
  58. ncbi Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
    T Nagasawa
    Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Japan
    Nature 382:635-8. 1996
    ..In addition, the mutants had a cardiac ventricular septal defect. Hence, we have shown that the chemokine PBSF/SDF-1 has several essential functions in development...
  59. ncbi The biology of IGE and the basis of allergic disease
    Hannah J Gould
    The Randall Centre, King s College London, United Kingdom
    Annu Rev Immunol 21:579-628. 2003
    ..Effective mechanisms ensure that allergic reactions are confined to mucosal tissues, thereby minimizing the risk of systemic anaphylaxis...
  60. pmc Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
    S R McKercher
    Burnham Institute, La Jolla, CA, USA
    EMBO J 15:5647-58. 1996
    ..While the PU.1 protein appears not to be essential for myeloid and lymphoid lineage commitment, it is absolutely required for the normal differentiation of B cells and macrophages...
  61. ncbi TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo
    B B Cazac
    Department of Medicine, The Windeyer Institute of Medical Sciences, University College, London, United Kingdom
    Immunity 13:443-51. 2000
    ..The data reveal differential roles of TbetaR in homeostasis and antigen responsiveness of B cell subpopulations and establish a critical function of the TGF-beta receptor ligand pair in the induction of IgA responses in vivo...
  62. pmc Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome
    Joanna Groom
    The Garvan Institute of Medical Research, Department of Arthritis and Inflammation, Darlinghurst, NSW, Australia
    J Clin Invest 109:59-68. 2002
    ..We conclude that altered B cell differentiation and tolerance induced by excess BAFF may be central to SS pathogenesis...
  63. ncbi Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology
    Roberta Magliozzi
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Brain 130:1089-104. 2007
    ....
  64. pmc Follicular helper T cells: lineage and location
    Nicolas Fazilleau
    Department of Immunology and Microbial Sciences, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Immunity 30:324-35. 2009
    ....
  65. ncbi Stepwise reprogramming of B cells into macrophages
    Huafeng Xie
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine Cancer Research Center, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell 117:663-76. 2004
    ..Our observations indicate that C/EBPalpha and beta remodel the transcription network of B cells into that of macrophages through a series of parallel and sequential changes that require endogenous PU.1...
  66. ncbi Impaired immune and acute-phase responses in interleukin-6-deficient mice
    M Kopf
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Nature 368:339-42. 1994
    ..We conclude that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes...
  67. ncbi Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    M Muramatsu
    Department of Medical Chemistry, Graduate School of Medicine, Institute for Virus Research, Kyoto University, Japan
    Cell 102:553-63. 2000
    ..These results suggest that AID may be involved in regulation or catalysis of the DNA modification step of both class switching and somatic hypermutation...
  68. ncbi A receptor for phosphatidylserine-specific clearance of apoptotic cells
    V A Fadok
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Nature 405:85-90. 2000
    ....
  69. pmc TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
    M A Lomaga
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada M5S 2S2
    Genes Dev 13:1015-24. 1999
    ..These findings establish unexpectedly diverse and critical roles for TRAF6 in perinatal and postnatal survival, bone metabolism, LPS, and cytokine signaling...
  70. pmc Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice
    Stefan Costinean
    Comprehensive Cancer Center, Ohio State University, 400 West 12th Avenue, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 103:7024-9. 2006
    ..These findings indicate that the role of miR155 is to induce polyclonal expansion, favoring the capture of secondary genetic changes for full transformation...
  71. ncbi B cell receptor signal strength determines B cell fate
    Stefano Casola
    CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Nat Immunol 5:317-27. 2004
    ..Furthermore, spontaneous germinal centers developed in gut-associated lymphoid tissue of LMP2A mice, indicating that microbial antigens can promote germinal centers independently of BCR-mediated antigen recognition...
  72. pmc Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells
    U Klein
    Institute for Cancer Genetics, Departments of Pathology and Genetics and Development, Columbia University, New York, NY 10032, USA
    J Exp Med 194:1625-38. 2001
    ..Finally, this analysis has identified a subset of genes specifically expressed by CLL cells of potential pathogenetic and clinical relevance...
  73. pmc PI3 kinase signals BCR-dependent mature B cell survival
    Lakshmi Srinivasan
    Program of Cellular and Molecular Medicine, Children s Hospital, and Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 139:573-86. 2009
    ....
  74. ncbi PI3K in lymphocyte development, differentiation and activation
    Klaus Okkenhaug
    Molecular Immunology Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Nat Rev Immunol 3:317-30. 2003
    ..Additional recent work has provided new insights into the molecular interactions that lead to PI3K activation and the signalling pathways that are regulated by PI3K...
  75. pmc CD4+ T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signaling
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 187:619-29. 1998
    ..Together, the data demonstrate that humoral immune response/FcR interactions can play a major role in negatively controlling inflammatory disease induced by CD4+ T cells...
  76. pmc Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development
    Matthew A Inlay
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 23:2376-81. 2009
    ....
  77. pmc B lymphocytes: how they develop and function
    Tucker W Lebien
    Department of Laboratory Medicine Pathology, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Blood 112:1570-80. 2008
    ..Some of the landmark discoveries that led to our current understanding of B lymphocytes as the source of protective innate and adaptive antibodies are highlighted in this essay...
  78. pmc A Tlr7 translocation accelerates systemic autoimmunity in murine lupus
    Srividya Subramanian
    Center for Immunology and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Proc Natl Acad Sci U S A 103:9970-5. 2006
    ....
  79. ncbi Reverse engineering of regulatory networks in human B cells
    Katia Basso
    Institute for Cancer Genetics, 1300 St Nicholas Avenue, Room 912, New York, New York 10032, USA
    Nat Genet 37:382-90. 2005
    ..The newly identified MYC targets include some major hubs. This approach can be generally useful for the analysis of normal and pathologic networks in mammalian cells...
  80. pmc B cells in HIV infection and disease
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 9:235-45. 2009
    ..This Review focuses on advances in our understanding of the mechanisms of B-cell dysfunction in HIV-associated disease and discusses similarities with other diseases that are associated with B-cell dysfunction...
  81. ncbi Toll-like receptor control of the adaptive immune responses
    Akiko Iwasaki
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
    Nat Immunol 5:987-95. 2004
    ..Recent studies have provided important clues about the mechanisms of TLR-mediated control of adaptive immunity orchestrated by dendritic cell populations in distinct anatomical locations...
  82. pmc Testing gene function early in the B cell lineage in mb1-cre mice
    E Hobeika
    Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Proc Natl Acad Sci U S A 103:13789-94. 2006
    ..The availability of a mouse line with efficient cre-mediated recombination at an early developmental stage in the B lineage provides an opportunity to study the role of various genes specifically in B cell development and function...
  83. ncbi Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain
    X Cao
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    Immunity 2:223-38. 1995
    ..These mice provide an important model for studying the pathophysiology provide an important model for studying the pathophysiology of and gene therapy for human XSCID...
  84. ncbi The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family
    G Mosialos
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115
    Cell 80:389-99. 1995
    ..The interaction of LMP1 with these TNFR family-associated proteins is further evidence for their role in signaling and links LMP1-mediated transformation to signal transduction from the TNFR family...
  85. ncbi Immunodeficiency in protein kinase cbeta-deficient mice
    M Leitges
    Max Delbruck Laboratorium in der Max Planck Gesellschaft, Carl von Linne Weg 10, D 50829 Köln, Germany
    Science 273:788-91. 1996
    ..Thus PKC-betaI and PKC-betaII play an important role in B cell activation and may be functionally linked to Bruton's tyrosine kinase in antigen receptor-mediated signal transduction...
  86. ncbi Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5
    Christopher D C Allen
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California 94143 0414, USA
    Nat Immunol 5:943-52. 2004
    ..In contrast, CXCR5 helped direct cells to the light zone and deficiency in CXCL13 was associated with aberrant light zone localization...
  87. pmc Cytokine-secreting follicular T cells shape the antibody repertoire
    R Lee Reinhardt
    Howard Hughes Medical Institute and Departments of Medicine and Microbiology and Immunology, University of California San Francisco, USA
    Nat Immunol 10:385-93. 2009
    ..Our findings support a model in which B cells compete for cytokines produced by follicular helper T cells that shape the affinity and isotype of the antibody response...
  88. pmc BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
    P Schneider
    Institute of Biochemistry, University of Lausanne, Switzerland
    J Exp Med 189:1747-56. 1999
    ..membrane-bound and soluble BAFF induced proliferation of anti-immunoglobulin M-stimulated peripheral blood B lymphocytes. Moreover, increased amounts of immunoglobulins were found in supernatants of germinal center-like B cells ..
  89. pmc Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes
    Dongsheng Xu
    Nebraska Center for Virology, School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588, USA
    J Virol 82:6251-8. 2008
    Epstein-Barr virus (EBV) infection is associated with many human malignancies. In vitro, EBV transforms primary B lymphocytes into continuously growing lymphoblastoid cell lines...
  90. ncbi Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjögren's syndrome
    Stina Salomonsson
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 48:3187-201. 2003
    ..To investigate functional properties of the germinal center (GC)-like structures observed in salivary glands of patients with Sjögren's syndrome (SS) and to determine the frequency with which such structures develop...
  91. ncbi Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
    Joseph T Opferman
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Department of Pathology and Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 426:671-6. 2003
    ..Thus, MCL-1, which selectively inhibits the proapoptotic protein BIM, is essential both early in lymphoid development and later on in the maintenance of mature lymphocytes...
  92. ncbi Fcgamma receptors: old friends and new family members
    Falk Nimmerjahn
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, New York 10021, USA
    Immunity 24:19-28. 2006
    ..This review will summarize recent results in Fc-receptor biology with an emphasis on data obtained in in vivo model systems...
  93. pmc Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation
    U D Bajpai
    Department of Pathology and Program in Immunology, Tufts University School of Medicine and Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts 02111, USA
    J Exp Med 191:1735-44. 2000
    ..Thus, BTK is essential for activation of NF-kappaB via the B cell receptor...
  94. ncbi 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination
    John P Manis
    Howard Hughes Medical Institute, The Children s Hospital, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 5:481-7. 2004
    ..We now examine potential functions for 53BP1 in the specific genomic alterations that occur in B lymphocytes. Although 53BP1 was dispensable for V(D)J recombination and somatic hypermutation (SHM), the processes by ..
  95. ncbi Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment
    Markus Krumbholz
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany
    Brain 129:200-11. 2006
    ..Therefore, both CXCL13 and CXCR5 may be promising therapeutic targets in multiple sclerosis...
  96. ncbi B cell antigen receptor signaling 101
    Joseph M Dal Porto
    Integrated Department of Immunology, University of Colorado Health Science Center and National Jewish Medical Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Mol Immunol 41:599-613. 2004
    ..b>B lymphocytes provide an archetypal model for such 'adaptive' cellular responses, where signals transmitted by the B cell Ag-..
  97. ncbi Tracking human antigen-specific memory B cells: a sensitive and generalized ELISPOT system
    Shane Crotty
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Rm G 211, Atlanta, GA 30322, USA
    J Immunol Methods 286:111-22. 2004
    ..This method should be useful for quantitatively assessing the potency of vaccines and the longevity of B cell immunological memory to various vaccines or infectious diseases...
  98. ncbi Synthesis and release of B-lymphocyte stimulator from myeloid cells
    B Nardelli
    Human Genome Sciences, Inc, Rockville, MD 20850, USA
    Blood 97:198-204. 2001
    ..These results provide further support for an important role for BLyS expressed in myeloid cells in B-cell expansion and antibody responses...
  99. pmc Follicular shuttling of marginal zone B cells facilitates antigen transport
    Guy Cinamon
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA
    Nat Immunol 9:54-62. 2008
    ..Marginal zone-follicle shuttling of marginal zone B cells provides an efficient mechanism for systemic antigen capture and delivery to follicular dendritic cells...
  100. ncbi The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
    J M Adams
    Nature 318:533-8. 1985
    ..Since the tumours represent represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leukaemogenic at several stages of B-cell maturation...
  101. ncbi A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene
    D Kitamura
    Institute for Genetics, University of Cologne, Germany
    Nature 350:423-6. 1991
    Of the various classes of antibodies that B lymphocytes can produce, class M (IgM) is the first to be expressed on the membrane of the developing cells...

Research Grants72

  1. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..Using this approach, we predict that we will be able to correlate SIV specific mucosal immune responses with reduction of viremia and protection from disease progression in macaques infected with pathogenic viruses. ..
  2. Immune Mechanism of Rejection in Human Lung Allografts
    Thalachallour Mohanakumar; Fiscal Year: 2013
    ..The overall goal of this proposal is to employ a safe and effective treatment regimen that targets B lymphocytes prior to and following LTx with the goal of reducing or removing Abs to self-Ags and HLA...
  3. Non-coding RNA engineers antibody diversity
    Uttiya Basu; Fiscal Year: 2011
    ..Antibodies are polypeptide complexes produced from B-lymphocytes that are present in the bodily fluids of vertebrates, and are used by the immune system to identify and neutralize foreign antigens, such as bacteria and viruses. ..
  4. In Vivo Function of TRAF6 As a Target of K63-Linked Polyubiquitination
    DEAN BALLARD; Fiscal Year: 2010
    ..RANK) and CD40, TNFR family members involved in the differentiation and effector functions of osteoclasts and B lymphocytes, respectively...
  5. Fnip1 Function in Lymphocyte Development, Activation and Metabolism
    Brian M Iritani; Fiscal Year: 2013
    ..innovative new strain of mice lacking Fnip1 in a chemical mutagenesis screen, based on the complete absence of B lymphocytes in peripheral blood...
  6. Regulation of KSHV Latency
    Paul M Lieberman; Fiscal Year: 2013
    ..Further elucidation of the molecular mechanisms regulating latency transcription will provide useful information for understanding and treating viral pathogenesis and disease. ..
  7. Phospholipid flip-flop in biogenic membranes
    Anant K Menon; Fiscal Year: 2013
    ..coli lipopolysaccharide. We are interested in identifying the transport proteins that catalyze lipid flipping in yeast and mammals and understanding how they work. ..
  8. Functional significance of Siglec-6, a novel leptin receptor, in human placental
    Virginia Winn; Fiscal Year: 2013
    ..While the B lymphocytes of all studied primates express Siglec-6, only human placenta expresses Siglec-6, which is intriguing given PE ..
  9. A Fourth Outcome: DNA Damage and the Differentiation of B Cells
    Michael A Teitell; Fiscal Year: 2013
    ..Our data show a new outcome for the DNA damage response (DDR) using B lymphocytes as the model system...
  10. Heat shock protein 90 antagonist-based therapy of mantle cell lymphoma
    Kapil Bhalla; Fiscal Year: 2012
    ..This strategy involves combinations of treatments with heat shock protein 90 and proteosome inhibitors designed to target protein folding and degradation in MCL cells. ..
  11. The Role of Beta-Arrestins 1 and 2 in Rheumatoid Arthritis
    Hongkuan Fan; Fiscal Year: 2010
    ..arrestin 1 and 2 expression in splenic macrophages, CD4+ and CD8+ T lymphocytes, B lymphocytes, dendritic cells (DC)s, polymorphonuclear leukocyte (PMN)s and FLS correlation to the disease severity in the ..
  12. The Kidney, Hypertension, Pregnancy and Inflammation
    Babbette LaMarca; Fiscal Year: 2013
    ..pregnant rats is associated with T helper cell activation which in turn mediate the production of AT1-AA via B lymphocytes. In addition, we propose that the AT1-AA and ANGII interact via the AT1 receptor to enhance the production of ..
  13. ACTIVATION INDUCED DEAMINASE (AID) INTERACTING PROTEINS
    Michel C Nussenzweig; Fiscal Year: 2011
    ..cytidine deaminase (AID) is a mutator enzyme that initiates somatic mutation and class switch recombination in B lymphocytes by introducing uracil:guanine mismatches into DNA...
  14. Murine Models for Mantle Cell Lymphoma: The role of tumor initiating cells (TIC)
    Richard J Ford; Fiscal Year: 2010
    ....
  15. Functional Analysis of PAAN-AG5, the Baboon Counterpart of HLA-G5
    Daudi K Langat; Fiscal Year: 2010
    ..This proposal is aimed at assessing the feasibility of using the olive baboon as a model for HLA-G in vivo experiments. ..
  16. Roles of Epstein-Barr virus nuclear antigens 2 and LP in B cell proliferation
    Elliott D Kieff; Fiscal Year: 2013
    ..EBV converts Resting B Lymphocytes (RBLs) to continuously proliferating Lymphoblasts (LCLs) by expressing Latency III EBV nuclear antigen ..
  17. Genome Wide Admixture Scan for Multiple Myeloma in African Americans
    CHRISTOPHER ALAN HAIMAN; Fiscal Year: 2013
    ..myeloma (MM) is a malignancy consisting of a neoplastic clone of plasma cells, the terminally-differentiated B lymphocytes responsible for antibody production...
  18. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael J Bevan; Fiscal Year: 2012
    ..It depends on the ability of the adaptive immune system, comprising T and B lymphocytes, to mount a rapid protective response to a second infection...
  19. The role of T lymphocytes in mediating hypertension during pregnancy
    Kedra L Wallace; Fiscal Year: 2013
    ..pregnant rats is associated with T helper cell activation which in turn mediate the production of AT1-AA via B lymphocytes. In addition, we propose that the AT1-AA via the AT1 receptor stimulates the production of ET-1 and ROS ..
  20. Oxidative Stress and Autoimmunity
    M Firoze Khan; Fiscal Year: 2013
    ..Following antigen processing, these neoantigens can elicit autoimmune responses by stimulating T and B lymphocytes, eventually leading to ADs such as systemic lupus erythematosus (SLE)...
  21. Intracellular Targeting of Proinflammatory Pathways to Ameliorate Type 1 Diabetes
    Daniel J Moore; Fiscal Year: 2010
    ..These interactions include requisite contributions from T cells, B lymphocytes, dendritic cells, and macrophages...
  22. B cell metabolism in activation and autoantibody production
    Jeffrey C Rathmell; Fiscal Year: 2013
    ..such as Systemic Lupus Erythematosus (SLE) are driven by disruption of regulatory mechanisms in both T and B lymphocytes leading to autoantibody production and inflammation...
  23. Mechanisms of Gene Regulation by EBV EBNA-1 Protein
    Jeffery T Sample; Fiscal Year: 2010
    ..virus (EBV) is an extremely successful pathogen, able to persist lifelong as a latent infection within B lymphocytes with little overt disease. However, a breakdown in immune surveillance, e.g...
  24. Role of ncRNA Surveillance Complex "RNA Exosome" in Class Switch Recombination an
    Uttiya Basu; Fiscal Year: 2013
    ..Understanding of AID function in B-lymphocytes will allow treatment of these patients with directed clinical therapies. ..
  25. MOLECULAR BASIS OF IMMUNOGLOBULIN HEAVY CHAIN SWITCH
    JANET M STAVNEZER; Fiscal Year: 2013
    Antibody (immunoglobulin, Ig) class switch causes B lymphocytes to switch from producing IgM to producing IgG, IgA or IgE, which improves the ability of the antibody to remove pathogens and bacterial toxins from the body...
  26. Id3/B Lymphocytes and Atherosclerosis
    Coleen A McNamara; Fiscal Year: 2010
    ..and T lymphocyte recruitment and function in the vessel wall have been extensively studied 8-10, the role of B lymphocytes remains incompletely understood...
  27. Toll-like receptor mediated regulation of effector and memory CD4 T cell response
    Chandrashekhar Pasare; Fiscal Year: 2013
    ..of myeloid origin such as DCs and macrophages, other cells such as neutrophils, epithelial cells, fibroblasts, B lymphocytes and T lymphocytes have been shown to express functional TLRs...
  28. Cannabinoid Epigenomic and miRNA mechanisms impact HIV/SIV disease progression
    Patricia E Molina; Fiscal Year: 2013
    ..and the major cannabinoid receptor subtypes (CB1 and CB2) as well as their localization (CB2predominantly on B lymphocytes and natural killer cells) has resulted in identification of multisystemic biomedical effects...
  29. Modulation of Autoimmune Diabetes by N-acetyl-D-glucosamine Specific B cells
    BRIAN L DIZON; Fiscal Year: 2010
    ..will examine a role for Group A Streptococcal (GAS) infection in modulating the function of antigen-specific B lymphocytes in mouse models of autoimmune diabetes...
  30. The Role of MicroRNA in Rheumatoid Arthritis Pathogenesis
    Hiroshi Asahara; Fiscal Year: 2010
    ..The synovial lining cells proliferate and the tissue is infiltrated by macrophages, T cells, and B lymphocytes. These cells are activated and produce inflammatory cytokines, such as tumor necrosis alpha (TNF-) and ..
  31. Modeling the KIF5B-RET Fusion Gene of Lung Cancer in Vivo
    Jie Wu; Fiscal Year: 2013
    ..This will provide an important resource for the research community to accelerate the generation of mouse models of newly identified molecular lesions. ..
  32. Genetic Regulation of B Lymphocyte Aortic Homing and Atheroprotection
    Coleen A McNamara; Fiscal Year: 2013
    ..Id3, as a novel atheroprotective factor that regulates expression of chemokine receptors and aortic homing of B lymphocytes and demonstrated that Id3 was essential for B lymphocyte-mediated atheroprotection...
  33. TGF beta-induced apoptosis in B-lymphocytes
    Philip H Howe; Fiscal Year: 2013
    ..by which TGF[unreadable] aids in maintenance of self tolerance through its induction of apoptosis in B lymphocytes. We have demonstrated that TGF[unreadable]-induced cell death is mediated through its induction of Bim, ..
  34. The Regulation of Somatic Hypermutation
    F Nina Papavasiliou; Fiscal Year: 2012
    ..the antibody repertoire is the product of gene diversification processes that take place in antibody producing B lymphocytes. The primary B cell repertoire is generated by somatic (V(D)J) recombination in the bone marrow during B cell ..
  35. Disconnecting CR2/CD21 from Its C3d Ligand to Ameliorate Lupus
    VERNON MICHAEL HOLERS; Fiscal Year: 2013
    ..High affinity autoantibodies and B lymphocytes play central roles in the immunopathogenesis of human systemic lupus erythematosus (SLE)...
  36. Amelioration of Immune Cell-Mediated Periodontal Disease
    Toshihisa Kawai; Fiscal Year: 2012
    ..T and B lymphocytes found in periodontal lesions express abundant RANKL, and stimulation of RANKL expression in these lymphocytes ..
  37. ASSEMBLY OF MHC CLASS I MOLECULES IN VITRO AND IN VIVO
    Hidde L Ploegh; Fiscal Year: 2012
    ..A second model concerns agammaglobulinemic mice that nonetheless possess a normally diverse set of B lymphocytes. This model allows a distinction between the antigen presenting function of B cells and the contribution of ..
  38. EBNA3C and tumor supressors
    Erle S Robertson; Fiscal Year: 2010
    ..These nascently infected B lymphocytes express a select set of latent genes one of which is the Epstein-Barr nuclear antigen (EBNA) 3C essential for ..
  39. CD19 Tyrosine-mediated Signal Transduction in vivo
    Louis B Justement; Fiscal Year: 2012
    b>B lymphocytes are required for host defense against infectious pathogens but abnormal activation of B cells can lead to autoimmunity. Thus, B cells are important in a wide range of physiologic and pathophysiologic processes...
  40. B1 B cells in abdominal obesity and diet-accelerated atherosclerosis in SLE
    Xuemei Zhong; Fiscal Year: 2013
    ..The result of this study will unravel unique aspects of B1 B lymphocytes in the abdominal cavity and omental milky spots and will provide a novel mechanism, as well as a non-static ..
  41. Molecular Phenotyping of NOD Mice
    Ivan C Gerling; Fiscal Year: 2010
    ..With a better understanding of these processes it will be possible to develop interventions that prevents this disease. ..
  42. Inherited Disorders of Lymphocyte Development
    Jennifer M Puck; Fiscal Year: 2013
    ..that mice lacking Zbtb1 (a previously unstudied zinc finger protein) cannot form T lymphocytes, though B lymphocytes are present. Zbtb1 is related to transcription factors that repress expression of their target genes...
  43. EBNA1 Functions Required in Burkitt's Lymphomas and Other Immortalized B-Cells
    AMBER TERESA WASHINGTON; Fiscal Year: 2012
    ..My studies will identify new therapeutic targets against diseases and malignancies caused by latent EBV infections. ..
  44. Mucosal Immune Ontogeny and Intestinal Microbiota in Infants
    Edward N Janoff; Fiscal Year: 2010
    ..Therefore, we hypothesize that: 1) The number of T and B lymphocytes and plasma cells will increase in number in the lamina propria of infants from birth to 2 years of age...
  45. Dissection of the ACPA response in African-Americans with Rheumatoid Arthritis
    S Louis Bridges; Fiscal Year: 2013
    ..anti-PAD4 Abs;and to assess the reactivity of antibodies from citrullinated protein-specific and PAD4-specific B lymphocytes in RA...
  46. Determining the compartmental role of B cell subsets during CNS autoimmunity
    Olaf Stuve; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): B lymphocytes are white blood cells that provide immunological protection against foreign proteins, including infections...
  47. Function of NADPH Oxidase(s) in T Lymphocytes
    Mark S Williams; Fiscal Year: 2010
    ..Expression of NADPH oxidase activity, however, is not restricted to phagocytes. Fibroblasts, B lymphocytes and platelets express NOX2/gp91phox protein which leads to ROS production...
  48. Role of ABH1's AP endonuclease activity in immunoglobulin gene diversification
    TINA A MUELLER; Fiscal Year: 2010
    ..If ABH1 is the enzyme responsible for cleaving AID/Ung induced abasic sites in developing B lymphocytes, this study will have high impact for understanding several critical steps in B cell differentiation, ..
  49. Pax5:Hematopoietic Transcription Factor Involved in ALL
    HAROLD PHILLIP KOEFFLER; Fiscal Year: 2013
    ..These studies will have importance for classification of the disease, offer new therapeutic targets and foster our understanding of the pathogenesis of ALL. ..
  50. Regulation of store-operated Ca2+ entry: STIM and ORAI
    Anjana Rao; Fiscal Year: 2013
    ..since STIM-ORAI proteins mediate store- operated Ca2+ entry not only in immune/ haematopoietic cells (T and B lymphocytes, mast cells, platelets) but also in skeletal muscle and potentially many other cell types...
  51. Genetic and Immunological Impact of the HRES-1/Rab4 Locus in SLE
    Andras Perl; Fiscal Year: 2013
    ..inflammatory disease characterized by circulating antinuclear autoantibodies and the dysfunction of T and B lymphocytes. Both genetic and environmental factors are believed to influence the development of the disease...
  52. GLUCOCORTICOSTEROID ACTION IN INFLAMMATORY DISEASE
    Robert P Schleimer; Fiscal Year: 2013
    ..and in vivo studies, we have advanced four important hypotheses to test: 1) that GC inhibit the recruitment of B lymphocytes and production of high concentrations of IgA and IgE in chronic rhinosinusitis (CRS);2) that GC improve ..
  53. Regulation of Sialoside Expression in Leukocytes
    James C Paulson; Fiscal Year: 2012
    ..sialic acid containing glycans as ligands, which are abundantly expressed as glycan chains of glycoproteins on B lymphocytes, T lymphocytes, and other cells that B lymphocytes come in contact with during activation and differentiation...
  54. Regulation of Inflammation-Associated Epithelial Cancer Development
    Lisa Marie Coussens; Fiscal Year: 2012
    ..Based on this hypothesis, the overall goal of this application is to examine whether specific targeting of B lymphocytes or instead, specific targeting of B lymphocyte effector pathways represent viable therapeutic targets for anti-..
  55. Regulation of cyclin D3 in B lymphocyte development
    Marcus R Clark; Fiscal Year: 2013
    ..process during which lineage-committed pro-B cells give rise to diverse peripheral populations of clonal B lymphocytes displaying a broad repertoire of antigen specificities...
  56. Restoration of Immune Tolerance in Type 1 Diabetes
    Daniel J Moore; Fiscal Year: 2013
    ..The PI's K08 award has focused on the role of regulatory B lymphocytes in the induction and maintenance of immune tolerance...
  57. Targeting of AID Mutagenic Activity
    David Kazadi; Fiscal Year: 2013
    ..Confined to the immunoglobulin (Ig) loci, these mutations confer to B lymphocytes the ability to drastically increase the diversity of the antibodies they produce (V(D)J recombination), to ..
  58. Anti Herpesvirus Signaling by LTab and LIGHT
    Carl F Ware; Fiscal Year: 2013
    ..mice, the LT-IFN axis is essential for lymphocyte survival during CMV infection and is mediated between naive B lymphocytes acting as innate effectors that induce IFN?? in virus-infected LT?R+ stromal cells in lymphoid tissues...
  59. Induction of Tolerance to Factor VIII in Hemophilia
    DAVID WILLIAM SCOTT; Fiscal Year: 2012
    ..We have utilized immunoglobulin (Ig) fusion proteins delivered to B lymphocytes via retroviral vectors for the induction of tolerance...
  60. Post-transcriptional Gene Regulation by EBV SM Protein
    Sankar Swaminathan; Fiscal Year: 2013
    ..EBV maintains a persistent but intermittently reactivating infection in B lymphocytes and contributes to the development of lymphoid and epithelial malignancies affecting millions of humans ..
  61. Gene Expression in Myeloma Cells
    Laurel A Eckhardt; Fiscal Year: 2010
    ..and somatic hypermutation are hallmarks of the immunoglobulin (Ig) loci in developing and antigen-reactive B lymphocytes. B lymphocytes must assemble the genes encoding Ig chains, and this process begins with VH gene assembly...
  62. Antibody Affinity Maturation in the Aging Bone Marrow
    Ferenc Livak; Fiscal Year: 2009
    ....
  63. Immunoglobulin Somatic Mutation
    Ursula Storb; Fiscal Year: 2007
    The process of somatic hypermutation (SHM) of immunoglobulin (Ig) genes takes place in B lymphocytes after specific interaction with antigen and T lymphocytes. SHM has several steps and requirements...
  64. Psychological stress, cortisol, and B lymphocyte decrements
    Bonnie McGregor; Fiscal Year: 2007
    ..One mechanism may involve stress-related increases in cortisol leading to decrements in B lymphocyte number. B lymphocytes are important for vaccine response...
  65. Positive and Negative Regulatory Pathways In Human Lymphoma
    Richard Ford; Fiscal Year: 2007
    ..expression of the TGF-beta/SMAD-SNO/SKI system, that is responsible for negative growth regulation in normal B lymphocytes (as well as many other functions in most cell types)...
  66. GLUCOCORTICOSTEROID ACTION IN INFLAMMATORY DISEASE
    Robert Schleimer; Fiscal Year: 2009
    ..and in vivo studies, we have advanced four important hypotheses to test: 1) that GC inhibit the recruitment of B lymphocytes and production of high concentrations of IgA and IgE in chronic rhinosinusitis (CRS);2) that GC improve ..
  67. TISSUE SPECIFIC GENE EXPRESSION
    Huntington Potter; Fiscal Year: 1990
    ..which are carried on viruses, the immunoglobulin enhancers are tissue specific--they only function in B lymphocytes. This suggests that B cells contain, as a result of their differentiation, proteins which are designed to ..
  68. C-MYC EXPRESSION AND APOPTOSIS IN B CELLS
    GAIL SONENSHEIN; Fiscal Year: 2007
    Treatment of WEHI 231 or CH33 immature B lymphocytes with antisera against their expressed surface IgM (anti- IgM), which serves as B Cell Receptor (BCR), induces G1/S phase growth arrest followed by apoptosis...
  69. Functional Analysis of HCV-B Lymphocyte Interactions
    Thomas Chambers; Fiscal Year: 2003
    ..CD81 is expressed on many different human cell types, including B lymphocytes, where it is known to associate with other molecules including CD19, MHC Class II antigen, lymphocytes, where ..
  70. RESEARCH CENTER IN ORAL BIOLOGY
    BEVERLY DALE CRUNK; Fiscal Year: 1999
    ..We will determine mechanisms by which cell-to-cell signals among B lymphocytes, T lymphocytes, and follicular dendritic cells are coordinated and regulated during activation and maturation ..
  71. VITAMIN D MEDIATED GENE REGULATION IN B LYMPHOCYTES
    John Morgan; Fiscal Year: 2000
    ..The applicant has observed that in normal human B lymphocytes upregulation of VDR and productive ligand-receptor modulation of target genes are discrete events which may be ..
  72. VIRUS ENCODED MIMITOPE PROCESSING IN AUTOIMMUNE DIABETES
    David Serreze; Fiscal Year: 1999
    ..Thus far, it is not known which specific subpopulations of antigen presenting cells (APCs - B lymphocytes, macrophages or dendritic cells) contribute to the development and activation of diabetogenic T lymphocytes...