pericardium

Summary

Summary: A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). The pericardium consists of two layers or sacs, the outer fibrous pericardium and the inner serous pericardium (or epicardium).

Top Publications

  1. ncbi Human epicardial adipose tissue is a source of inflammatory mediators
    Tomasz Mazurek
    Department of Surgery, Thomas Jefferson University, Suite 623, 1025 Walnut St, Philadelphia, PA 19107, USA
    Circulation 108:2460-6. 2003
  2. ncbi A myocardial lineage derives from Tbx18 epicardial cells
    Chen Leng Cai
    Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California 92093, USA
    Nature 454:104-8. 2008
  3. pmc Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
    Bin Zhou
    Harvard Stem Cell Institute and Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 454:109-13. 2008
  4. pmc Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin
    Ofelia M Martinez-Estrada
    MRC Human Genetics Unit and Institute for Genetics and Molecular Medicine, Edinburgh, UK
    Nat Genet 42:89-93. 2010
  5. ncbi Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization
    Nicola Smart
    Molecular Medicine Unit, UCL Institute of Child Health, London WC1N 1EH, UK
    Nature 445:177-82. 2007
  6. pmc Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease
    Adam R Baker
    Unit for Diabetes and Metabolism, Warwick Medical School, University of Warwick, Clinical Sciences Research Institute, UHCW Campus, Coventry, CV2 2DX, UK
    Cardiovasc Diabetol 5:1. 2006
  7. ncbi Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction
    Gianluca Iacobellis
    Endocrinology, Department of Clinical Sciences, La Sapienza University, Rome Italy
    Obes Res 11:304-10. 2003
  8. ncbi Human epicardial adipose tissue: a review
    Harold S Sacks
    Division of Endocrinology and Metabolism, University of Tennessee, and Baptist Hospital Heart Institute, Memphis, TN, USA
    Am Heart J 153:907-17. 2007
  9. ncbi Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk
    Gianluca Iacobellis
    Endocrinology, Department of Clinical Sciences, La Sapienza University, 00161 Rome, Italy
    J Clin Endocrinol Metab 88:5163-8. 2003
  10. pmc Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham Heart Study
    Amir A Mahabadi
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 165 Charles River Plaza, Boston, MA 02114, USA
    Eur Heart J 30:850-6. 2009

Detail Information

Publications372 found, 100 shown here

  1. ncbi Human epicardial adipose tissue is a source of inflammatory mediators
    Tomasz Mazurek
    Department of Surgery, Thomas Jefferson University, Suite 623, 1025 Walnut St, Philadelphia, PA 19107, USA
    Circulation 108:2460-6. 2003
    ..In this study, we sought to compare expression of inflammatory mediators in epicardial and subcutaneous adipose stores in patients with critical CAD...
  2. ncbi A myocardial lineage derives from Tbx18 epicardial cells
    Chen Leng Cai
    Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California 92093, USA
    Nature 454:104-8. 2008
    ..The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration...
  3. pmc Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
    Bin Zhou
    Harvard Stem Cell Institute and Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 454:109-13. 2008
    ..These results identify Wt1(+) epicardial cells as previously unrecognized cardiomyocyte progenitors, and lay the foundation for future efforts to harness the cardiogenic potential of these progenitors for cardiac regeneration and repair...
  4. pmc Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin
    Ofelia M Martinez-Estrada
    MRC Human Genetics Unit and Institute for Genetics and Molecular Medicine, Edinburgh, UK
    Nat Genet 42:89-93. 2010
    ..These new insights into the molecular mechanisms regulating cardiovascular progenitor cells and EMT will shed light on the pathogenesis of heart diseases and may help the development of cell-based therapies...
  5. ncbi Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization
    Nicola Smart
    Molecular Medicine Unit, UCL Institute of Child Health, London WC1N 1EH, UK
    Nature 445:177-82. 2007
    ....
  6. pmc Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease
    Adam R Baker
    Unit for Diabetes and Metabolism, Warwick Medical School, University of Warwick, Clinical Sciences Research Institute, UHCW Campus, Coventry, CV2 2DX, UK
    Cardiovasc Diabetol 5:1. 2006
    ..Inflammation contributes to cardiovascular disease and is exacerbated with increased adiposity, particularly omental adiposity; however, the role of epicardial fat is poorly understood...
  7. ncbi Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction
    Gianluca Iacobellis
    Endocrinology, Department of Clinical Sciences, La Sapienza University, Rome Italy
    Obes Res 11:304-10. 2003
    ..VAT is recognized as an important indicator of high cardiovascular and metabolic risk. Several methods are applied to estimate VAT, with different results...
  8. ncbi Human epicardial adipose tissue: a review
    Harold S Sacks
    Division of Endocrinology and Metabolism, University of Tennessee, and Baptist Hospital Heart Institute, Memphis, TN, USA
    Am Heart J 153:907-17. 2007
    ..Further studies should be done to test the hypothesis that adipokines produced by and released from human epicardial adipose tissue might contribute locally to the pathogenesis of coronary atherosclerosis...
  9. ncbi Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk
    Gianluca Iacobellis
    Endocrinology, Department of Clinical Sciences, La Sapienza University, 00161 Rome, Italy
    J Clin Endocrinol Metab 88:5163-8. 2003
    ..387; P = 0.03) were the strongest independent variables correlated with epicardial adipose tissue. Echocardiographic epicardial adipose tissue could be applied as an easy and reliable imaging indicator of VAT and cardiovascular risk...
  10. pmc Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham Heart Study
    Amir A Mahabadi
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 165 Charles River Plaza, Boston, MA 02114, USA
    Eur Heart J 30:850-6. 2009
    ..The aim of this study was to assess whether pericardial fat, intrathoracic fat, and visceral abdominal adipose tissue (VAT) are associated with the prevalence of cardiovascular disease (CVD)...
  11. ncbi Pericardial fat is associated with atrial fibrillation severity and ablation outcome
    Christopher X Wong
    Centre for Heart Rhythm Disorders CHRD, Royal Adelaide Hospital and the University of Adelaide, Adelaide, Australia
    J Am Coll Cardiol 57:1745-51. 2011
    ..The aim of this study was to characterize the relationship between pericardial fat and atrial fibrillation (AF)...
  12. ncbi Pericardial and thoracic peri-aortic adipose tissues contribute to systemic inflammation and calcified coronary atherosclerosis independent of body fat composition, anthropometric measures and traditional cardiovascular risks
    Chun Ho Yun
    Department of Radiology, Mackay Memorial Hospital, Taipei, Taiwan
    Eur J Radiol 81:749-56. 2012
    ..However, clinical data regarding the independent value of visceral adipose tissue in addition to such traditional predictors remains obscure...
  13. pmc Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling
    Christopher L Smith
    Department of Molecular Biology, MC9148, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Circ Res 108:e15-26. 2011
    ..Therefore, we investigated the combined and independent roles of these receptors in epicardial development...
  14. pmc Myocardial, perivascular, and epicardial fat
    Patricia Iozzo
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    Diabetes Care 34:S371-9. 2011
    ..Functional or hybrid imaging may contribute to a better definition of disease severity and unveil the direct myocardial and vascular targets of adipose tissue action...
  15. ncbi Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis
    Gonzalo del Monte
    Lab Biología Celular y del Desarrollo, Dpto de Biología del Desarrollo Cardiovascular, Centro Nacional de Investigaciones Cardiovasculares, Melchor Fernandez Almagro 3, Madrid, Spain
    Circ Res 108:824-36. 2011
    ..During cardiac development, epicardial-derived cells also contribute to coronary vessel morphogenesis...
  16. pmc Computer-aided non-contrast CT-based quantification of pericardial and thoracic fat and their associations with coronary calcium and Metabolic Syndrome
    Damini Dey
    Departments of Imaging and Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Atherosclerosis 209:136-41. 2010
    ....
  17. ncbi Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features
    Gianluca Iacobellis
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL, USA
    Trends Endocrinol Metab 22:450-7. 2011
    ..Particular emphasis is placed on the paracrine/endocrine properties of epicardial fat and its role in the development and progression of atherosclerosis...
  18. pmc Adult mouse epicardium modulates myocardial injury by secreting paracrine factors
    Bin Zhou
    Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts, USA
    J Clin Invest 121:1894-904. 2011
    ..Our findings indicate that epicardium modulates the cardiac injury response by conditioning the subepicardial environment, potentially offering a new therapeutic strategy for cardiac protection...
  19. ncbi Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart
    Gianluca Iacobellis
    Department of Medicine, Cardiovascular Obesity Research and Management, Michael G DeGroote School of Medicine, Hamilton, Ontario, Canada
    Nat Clin Pract Cardiovasc Med 2:536-43. 2005
    ..In this paper, we briefly review the rapidly emerging evidence pointing to a specific role of epicardial adipose tissue both as a cardiac risk marker and as a potentially active player in the development of cardiac pathology...
  20. pmc Adult cardiac-resident MSC-like stem cells with a proepicardial origin
    James J H Chong
    Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, 2010, Australia
    Cell Stem Cell 9:527-40. 2011
    ..These diverse origins for CFU-Fs suggest an underlying basis for differentiation biases seen in different CFU-F populations, and could also influence their capacity for participating in tissue repair...
  21. ncbi Epicardial fat: an additional measurement for subclinical atherosclerosis and cardiovascular risk stratification?
    Matthew R Nelson
    Mayo Clinic, Scottsdale, AZ, USA
    J Am Soc Echocardiogr 24:339-45. 2011
    ....
  22. ncbi Total and interatrial epicardial adipose tissues are independently associated with left atrial remodeling in patients with atrial fibrillation
    Seung Yong Shin
    Department of Radiology, Korea University Guro Hospital, Korea University of College of Medicine, Seoul, Korea
    J Cardiovasc Electrophysiol 22:647-55. 2011
    ..The aims of this study were to determine whether the amount and regional distribution of EAT are related to the chronicity of atrial fibrillation (AF) and left atrial (LA) remodeling...
  23. ncbi Pericardial fat is independently associated with human atrial fibrillation
    M Obadah Al Chekakie
    Loyola University Medical Center, Maywood, Illinois, USA
    J Am Coll Cardiol 56:784-8. 2010
    ..The purpose of this study was to investigate the association between atrial fibrillation (AF) and pericardial fat...
  24. ncbi Increased volume of epicardial fat is an independent risk factor for accelerated progression of sub-clinical coronary atherosclerosis
    Ajay Yerramasu
    Clinical Imaging and Research Centre, Wellington Hospital, London NW8 9LE, United Kingdom
    Atherosclerosis 220:223-30. 2012
    ..We examined the association of EAT with metabolic syndrome and the prevalence and progression of coronary artery calcium (CAC) burden...
  25. pmc Association of chemerin mRNA expression in human epicardial adipose tissue with coronary atherosclerosis
    Xiuying Gao
    Department of Endocrinology, The Key Laboratory of Remodeling related Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Ministry of Education, Beijing, 100029, China
    Cardiovasc Diabetol 10:87. 2011
    ..In this study, we sought to determine the relationship of chemerin expression in EAT and the severity of coronary atherosclerosis in Han Chinese patients...
  26. ncbi Epicardial adipose tissue and coronary artery plaque characteristics
    Nikolaos Alexopoulos
    Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA, United States
    Atherosclerosis 210:150-4. 2010
    ..Epicardial adipose tissue (EAT) has been implicated in the pathogenesis of coronary atherosclerosis. The association of EAT volume with type of coronary artery plaque on computed tomography angiography (CTA) is not known...
  27. ncbi Adipokines in periaortic and epicardial adipose tissue: differential expression and relation to atherosclerosis
    Sofia G Spiroglou
    Department of Anatomy and Histology, School of Medicine, University of Patras, Patras, Greece
    J Atheroscler Thromb 17:115-30. 2010
    ..We investigated the expression of adiponectin, visfatin, leptin and novel adipokines chemerin and vaspin in human periaortic and epicardial adipose tissue, as well as their correlation to aortic and coronary atherosclerosis...
  28. ncbi Increased epicardial adipose tissue (EAT) volume in type 2 diabetes mellitus and association with metabolic syndrome and severity of coronary atherosclerosis
    Chao Ping Wang
    Department of Internal Medicine, Division of Cardiology, E Da Hospital, I Shou University, Kaohsiung 82445, Taiwan
    Clin Endocrinol (Oxf) 70:876-82. 2009
    Epicardial adipose tissue (EAT) is a part of visceral fat deposited around the heart between the pericardium and myocardium along the distribution of coronary arteries...
  29. ncbi Experimental studies on the spatiotemporal expression of WT1 and RALDH2 in the embryonic avian heart: a model for the regulation of myocardial and valvuloseptal development by epicardially derived cells (EPDCs)
    J M Pérez-Pomares
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina, 29425, USA
    Dev Biol 247:307-26. 2002
    ..Furthermore, we propose that an interaction between EPDCs and endocardial (derived) cells is imperative for correct development of the AV cushions...
  30. ncbi Association of epicardial adipose tissue with coronary atherosclerosis is region-specific and independent of conventional risk factors and intra-abdominal adiposity
    Tzung Dau Wang
    Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Atherosclerosis 213:279-87. 2010
    ....
  31. pmc The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Jingzhong Ding
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Clin Nutr 90:499-504. 2009
    ..Cross-sectional studies suggest that pericardial fat is positively associated with coronary artery disease independent of total body fat...
  32. ncbi Wt1 and epicardial fate mapping
    Carsten Rudat
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circ Res 111:165-9. 2012
    ..Genetic lineage tracing systems based on Wt1 regulatory sequences provided evidence that epicardium-derived cells also adopt a myocardial fate in the mouse...
  33. ncbi Potential atrial arrhythmogenicity of adipocytes: implications for the genesis of atrial fibrillation
    Yung Kuo Lin
    Cardiovascular Center, Far Eastern Memorial Hospital, Taipei, Taiwan
    Med Hypotheses 74:1026-9. 2010
    ..Taken together, we hypothesized that epicardial adipocytes contain distinctive arrhythmogenicity through increases in inflammatory cytokines, adipocytokines, and adipocyte-cardiomyocyte interactions to induce atrial fibrillation...
  34. pmc Decreased adiponectin and increased inflammation expression in epicardial adipose tissue in coronary artery disease
    Yuan Zhou
    Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China
    Cardiovasc Diabetol 10:2. 2011
    ..However, expression of adiponectin in epicardial adipose tissue and its function in CAD pathogenesis is unclear. This study investigates adiponectin expression in epicardial adipose tissue in CAD patients...
  35. ncbi Expression of adrenomedullin in human epicardial adipose tissue: role of coronary status
    Alina Silaghi
    INSERM U626, Aix Marseille Universite, Marseille Cedex 5, France
    Am J Physiol Endocrinol Metab 293:E1443-50. 2007
    ..Our data suggest that eWAT AM, which could originate from macrophages, is related to 11beta-HSD-1 expression. AM synthesis, which is increased in eWAT during chronic CAD in humans, can play a cardioprotective role...
  36. ncbi Echocardiographic epicardial fat: a review of research and clinical applications
    Gianluca Iacobellis
    Department of Medicine, Division of Endocrinology, McMaster University, Ontario, Canada
    J Am Soc Echocardiogr 22:1311-9; quiz 1417-8. 2009
    ..generally identified as the echo-free space between the outer wall of the myocardium and the visceral layer of pericardium and is measured perpendicularly on the free wall of the right ventricle at end-systole...
  37. ncbi Increased subcutaneous and epicardial adipose tissue production of proinflammatory cytokines in cardiac surgery patients: possible role in postoperative insulin resistance
    Jaromir Kremen
    Third Department of Medicine, First Faculty of Medicine, Charles University, U Nemocnice 1, 128 08, Prague 2, Czech Republic
    J Clin Endocrinol Metab 91:4620-7. 2006
    ..Hyperglycemia and insulin resistance frequently occur in critically ill patients even without a history of diabetes...
  38. ncbi Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels
    Mikko Kankaanpaa
    Turku PET Centre, University of Turku, FIN 20521, Turku, Finland
    J Clin Endocrinol Metab 91:4689-95. 2006
    ..We evaluated myocardial and epicardial fat, left ventricular (LV) function, and metabolic risk factors in nine (five lean, four moderately obese) men...
  39. ncbi Threshold values of high-risk echocardiographic epicardial fat thickness
    Gianluca Iacobellis
    Department of Medicine, Cardiovascular Obesity Research and Management, McMaster University, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 16:887-92. 2008
    ..In this study, we sought to provide threshold values of echocardiographic epicardial fat thickness associated with metabolic and anthropometric risk factors...
  40. ncbi Visceral adiposity and arterial stiffness: echocardiographic epicardial fat thickness reflects, better than waist circumference, carotid arterial stiffness in a large population of hypertensives
    Francesco Natale
    Department of Cardiothoracic Sciences, Second University of Naples, Monaldi Hospital, Via L Bianchi 1, Naples, Italy
    Eur J Echocardiogr 10:549-55. 2009
    ....
  41. pmc Pericardial fat, intrathoracic fat, and measures of left ventricular structure and function: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Circulation 119:1586-91. 2009
    ..Whether the associations of pericardial fat and measures of cardiac structure and function are independent of the systemic effects of obesity and visceral adiposity has not been fully explored...
  42. ncbi Epicardial adipose tissue thickness by echocardiography is a marker for the presence and severity of coronary artery disease
    S Eroglu
    Department of Cardiology, Baskent University Faculty of Medicine, 10 Sok No 45, 06490 Bahcelievler, Ankara, Turkey
    Nutr Metab Cardiovasc Dis 19:211-7. 2009
    ..We aimed to test the hypothesis that echocardiographic EAT thickness can be a marker for the presence and severity of coronary artery disease (CAD)...
  43. ncbi Epicardial adipose tissue and insulin resistance in obese subjects
    Gianluca Iacobellis
    Dipartimento di Scienze Cliniche, Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy
    J Clin Endocrinol Metab 90:6300-2. 2005
    ..Epicardial fat reflects intraabdominal visceral fat, and the echocardiographic assessment of this tissue is an easy and reliable marker of visceral adiposity...
  44. ncbi Epicardial adipose tissue as a source of nuclear factor-kappaB and c-Jun N-terminal kinase mediated inflammation in patients with coronary artery disease
    A R Baker
    Unit for Diabetes and Metabolism, University of Warwick, Warwick Medical School, Clinical Sciences Research Institute, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, United Kingdom
    J Clin Endocrinol Metab 94:261-7. 2009
    ..Epicardial AT expresses an inflammatory profile of proteins; however, the mechanisms responsible are yet to be elucidated...
  45. pmc Impact of body mass index on the relationship of epicardial adipose tissue to metabolic syndrome and coronary artery disease in an Asian population
    Jin Sun Park
    Department of Cardiology, Ajou University School of Medicine, Suwon, Korea
    Cardiovasc Diabetol 9:29. 2010
    ..Several studies on obese patients, however, failed to demonstrate any relationship between EAT and CAD. We hypothesized that body mass index (BMI) affected the link between EAT and MS and CAD...
  46. pmc Prevalence, distribution, and risk factor correlates of high pericardial and intrathoracic fat depots in the Framingham heart study
    George Thanassoulis
    National Institutes of Health National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, MA, Boston, USA
    Circ Cardiovasc Imaging 3:559-66. 2010
    ..We sought to determine the prevalence, distribution, and risk factor correlates of high pericardial and intrathoracic fat deposits...
  47. ncbi Cloning and expression analysis of the mouse T-box gene Tbx18
    F Kraus
    Max Planck Institut fur Immunbiologie, Abt Molekulare Embryologie, Stubeweg 51, 79108 Freiburg, Germany
    Mech Dev 100:83-6. 2001
    ..Other sites of expression include the cranial paraxial mesoderm, the presomitic mesoderm, the anterior somite half, the genital ridge, and the developing limb buds...
  48. ncbi Adipose tissue gene expression of adiponectin, tumor necrosis factor-α and leptin in metabolic syndrome patients with coronary artery disease
    Selcuk Gormez
    Department of Cardiology, Florence Nightingale Hospital, Turkey
    Intern Med 50:805-10. 2011
    ....
  49. pmc Pericardial fat burden on ECG-gated noncontrast CT in asymptomatic patients who subsequently experience adverse cardiovascular events
    Victor Y Cheng
    Department of Imaging, Cedars Sinai Medical Center, Los Angeles, California, USA
    JACC Cardiovasc Imaging 3:352-60. 2010
    ..We aimed to evaluate whether pericardial fat has value in predicting the risk of future adverse cardiovascular outcomes...
  50. ncbi Origin of coronary endothelial cells from epicardial mesothelium in avian embryos
    José María Pérez-Pomares
    Department of Cell Biology and Anatomy, Medical University of South Carolina, USA
    Int J Dev Biol 46:1005-13. 2002
    ....
  51. ncbi Relation of echocardiographic epicardial fat thickness and myocardial fat
    Alexis Elias Malavazos
    Department of Medical and Surgical Sciences, University of Milan, IRCCS Policlinico San Donato, San Donato Milanese, Italy
    Am J Cardiol 105:1831-5. 2010
    ....
  52. ncbi Relationship between epicardial fat measured by 64-multidetector computed tomography and coronary artery disease
    Kohichiro Iwasaki
    Department of Cardiology, Okayama Central Hospital, Okayama, Japan
    Clin Cardiol 34:166-71. 2011
    Epicardial fat (EF) is the visceral fat of the heart deposited under the visceral layer of the pericardium and has the same origin as abdominal visceral fat, which is shown to be strongly related to the development of coronary artery ..
  53. ncbi Association of epicardial fat, hypertension, subclinical coronary artery disease, and metabolic syndrome with left ventricular diastolic dysfunction
    Joao L Cavalcante
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 110:1793-8. 2012
    ..In conclusion, EFV is an independent predictor of impaired diastolic function in apparently healthy overweight patients even after accounting for associated co-morbidities such as metabolic syndrome, hypertension, and subclinical CAD...
  54. ncbi Decellularization of pericardial tissue and its impact on tensile viscoelasticity and glycosaminoglycan content
    Birzabith Mendoza-Novelo
    Departamento de Quimica, Universidad de Guanajuato, Noria Alta s n, 36050 Guanajuato, Gto, Mexico
    Acta Biomater 7:1241-8. 2011
    Bovine pericardium is a collagenous tissue commonly used as a natural biomaterial in the fabrication of cardiovascular devices...
  55. ncbi Epicardium-derived cells contribute a novel population to the myocardial wall and the atrioventricular cushions
    A C Gittenberger-de Groot
    Department of Anatomy and Embryology, Leiden University Medical Center, Netherlands
    Circ Res 82:1043-52. 1998
    ..Furthermore, a regulatory role is postulated in the process of endocardial-mesenchymal transformation. The ultimate fate of EPDCs seems to be a cardiac fibroblast cell line involved in the formation of the fibrous heart skeleton...
  56. ncbi Subepicardial adipose tissue and the presence and severity of coronary artery disease
    Nithima Chaowalit
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Atherosclerosis 186:354-9. 2006
    ..Mechanistic studies suggest that paracrine effects of subepicardial adipose tissue may promote coronary atherosclerosis, but this has not been confirmed in clinical studies...
  57. ncbi Echocardiographic parameters of epicardial fat deposition and its relation to coronary artery disease
    Juan Valiente Mustelier
    National Cardiology and Cardiovascular Surgery Institute, Havana, Cuba
    Arq Bras Cardiol 97:122-9. 2011
    ..However, the association of lipomatous infiltration of the atrial septum and fat infiltration of the right ventricle remains uncertain. None of these parameters has been thoroughly studied in Hispanic patients...
  58. ncbi Association between epicardial adipose tissue volumes on 3-dimensional reconstructed CT images and recurrence of atrial fibrillation after catheter ablation
    Koichi Nagashima
    Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Circ J 75:2559-65. 2011
    ..Whether epicardial adipose tissue (EAT) is independently associated with atrial fibrillation (AF) and outcome after catheter ablation (CA) for AF remains unclear...
  59. ncbi Phase 2 reentry as a mechanism of initiation of circus movement reentry in canine epicardium exposed to simulated ischemia
    A Lukas
    Masonic Medical Research Laboratory, Utica, NY 13501 1787, USA
    Cardiovasc Res 32:593-603. 1996
    ..However, the trigger that initiates reentry remains unknown. We studied the initiation of reentry attending the development of electrical heterogeneity during simulated ischemia in isolated canine right ventricular subepicardium...
  60. ncbi Association between epicardial adipose tissue volume and characteristics of non-calcified plaques assessed by coronary computed tomographic angiography
    Toshiharu Oka
    Department of Cardiovascular Medicine, Hiroshima University, Graduate School of Biomedical Sciences, and Department of Clinical Radiology, Hiroshima University Hospital, Hiroshima, Japan
    Int J Cardiol 161:45-9. 2012
    ..The aim of this study was to investigate whether high epicardial adipose tissue (EAT) volume is related to the presence of vulnerable coronary plaque components as assessed by computed tomography (CT)...
  61. pmc Epicardially derived fibroblasts preferentially contribute to the parietal leaflets of the atrioventricular valves in the murine heart
    Andy Wessels
    Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA
    Dev Biol 366:111-24. 2012
    ....
  62. pmc Wt1 controls retinoic acid signalling in embryonic epicardium through transcriptional activation of Raldh2
    Juan Antonio Guadix
    Department of Animal Biology, University of Malaga, E29071 Malaga, Spain
    Development 138:1093-7. 2011
    ....
  63. ncbi Peri-coronary epicardial adipose tissue is related to cardiovascular risk factors and coronary artery calcification in post-menopausal women
    Alexander M de Vos
    Department of Cardiology, University Medical Centre Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
    Eur Heart J 29:777-83. 2008
    ..To determine whether peri-coronary epicardial adipose tissue (EAT) is associated with vascular risk factors and coronary atherosclerosis...
  64. ncbi Tbx18 and the fate of epicardial progenitors
    Vincent M Christoffels
    Department of Anatomy and Embryology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 15 L2 108, 1105 AZ Amsterdam, The Netherlands
    Nature 458:E8-9; discussion E9-10. 2009
    ....
  65. pmc Inflammatory genes in epicardial fat contiguous with coronary atherosclerosis in the metabolic syndrome and type 2 diabetes: changes associated with pioglitazone
    Harold S Sacks
    Department of Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Diabetes Care 34:730-3. 2011
    ..To determine changes in gene expression in epicardial adipose tissue (EAT) associated with coronary atherosclerosis (CAD) and effects of pioglitazone therapy...
  66. pmc Cardiac regeneration from activated epicardium
    Bram van Wijk
    Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 7:e44692. 2012
    ..These molecular and cellular analyses provide basic knowledge essential for investigations on the regeneration of the mammalian heart aiming at epicardium-derived cells...
  67. ncbi A 2D FE model of the heart demonstrates the role of the pericardium in ventricular deformation
    Carol A Gibbons Kroeker
    Dept of Cardiac Sciences, Faculty of Medicine, Univ of Calgary, Health Sciences Centre, 3330 Hospital Dr NW, Calgary, AB, Canada
    Am J Physiol Heart Circ Physiol 291:H2229-36. 2006
    ..This study examines the effects of acute PAC on the left ventricular (LV) free wall and the role the pericardium may play in these effects...
  68. ncbi Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart
    B Andree
    Cell and Molecular Biology, Technical University of Braunschweig, Brunswick, 38106, Germany
    Dev Biol 223:371-82. 2000
    ..The strong conservation of POP genes during evolution and their preferential expression in heart and skeletal muscle suggest that these novel proteins may have an important function in these tissues in vertebrates...
  69. ncbi Development and characterization of an acellular human pericardial matrix for tissue engineering
    Saeed Mirsadraee
    The Institute of Medical and Biological Engineering, University of Leeds, Leeds, United Kingdom
    Tissue Eng 12:763-73. 2006
    ..human tissue scaffold with a view to recellularization with autologous cells to produce a tissue-engineered pericardium that can be used as a patch for cardiovascular repair...
  70. ncbi Pericardial rather than epicardial fat is a cardiometabolic risk marker: an MRI vs echo study
    Rosa Sicari
    National Research Council Institute of Clinical Physiology, Pisa, Italy
    J Am Soc Echocardiogr 24:1156-62. 2011
    ..The aims of this study were to validate echocardiographic analyses compared with MRI and to evaluate which cardiac fat depot (EPI or PERI) is the most appropriate cardiovascular risk marker...
  71. ncbi Epicardial adipose tissue is an independent predictor of coronary atherosclerotic burden
    N Bettencourt
    Cardiology Department, Centro Hospitalar de Gaia Espinho, Portugal Kings College London, United Kingdom
    Int J Cardiol 158:26-32. 2012
    ..The aim of this work was to study the relations between EAT, abdominal visceral fat (AVF), and coronary atherosclerotic burden as assessed by multislice computed tomography (MSCT)...
  72. ncbi Biocompatibility and calcification of bovine pericardium employed for the construction of cardiac bioprostheses treated with different chemical crosslink methods
    Eduardo Jorge-Herrero
    Divisão de Biomateriais, INEB Instituto de Engenharia Biomedica, Universidade do Porto, Porto, Portugal
    Artif Organs 34:E168-76. 2010
    ..in vitro biocompatibility, the mechanical properties, and in vivo calcification of chemically modified bovine pericardium using glutaraldehyde acetals (GAAs) in comparison with glutaraldehyde (GA) treatment...
  73. ncbi Notch signaling regulates smooth muscle differentiation of epicardium-derived cells
    Thomas Grieskamp
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, Hannover, Germany
    Circ Res 108:813-23. 2011
    ....
  74. pmc Pericardial disease: diagnosis and management
    Masud H Khandaker
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 85:572-93. 2010
    ..Structural abnormalities including congenitally absent pericardium and pericardial cysts are usually asymptomatic and are uncommon...
  75. ncbi Self-made pericardial tube graft: a new surgical concept for treatment of graft infections after thoracic and abdominal aortic procedures
    Martin Czerny
    Department of Cardiovascular Surgery, University Hospital Berne, Berne, Switzerland
    Ann Thorac Surg 92:1657-62. 2011
    ..The aim of this study was to evaluate a new surgical concept for the treatment of graft infections after operation or endovascular treatment of thoracic, thoracoabdominal, and abdominal aortic diseases...
  76. pmc The transcriptome of human epicardial, mediastinal and subcutaneous adipose tissues in men with coronary artery disease
    Sandra Guauque-Olarte
    Centre de Recherche Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, Quebec, Canada
    PLoS ONE 6:e19908. 2011
    ....
  77. pmc tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration
    Kazu Kikuchi
    Department of Cell Biology and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Development 138:2895-902. 2011
    ..Our findings indicate that natural epicardial fates are limited to non-myocardial cell types in zebrafish...
  78. ncbi FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium
    S G Tevosian
    Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cell 101:729-39. 2000
    ..Our findings provide the molecular inroad into the induction of coronary vasculature by myocardium in the developing heart...
  79. ncbi Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue
    Yoichiro Hirata
    Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    J Am Coll Cardiol 58:248-55. 2011
    ..The purpose of this report was to assess the link between macrophage polarization in epicardial adipose tissue and atherosclerosis in patients with coronary artery disease (CAD)...
  80. ncbi Epicardial/Mesothelial cell line retains vasculogenic potential of embryonic epicardium
    Aya M Wada
    Stahlman Cardiovascular Laboratories, Program for Developmental Biology, and the Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tenn 37232 6300, USA
    Circ Res 92:525-31. 2003
    ..Thus, this study provides evidence that these cells can serve as an important model system for the analysis of the cellular and molecular mechanisms that govern epicardial development and function...
  81. ncbi Late outcomes for aortic valve replacement with the Carpentier-Edwards pericardial bioprosthesis: up to 17-year follow-up in 1,000 patients
    R Scott McClure
    Division of Cardiac Surgery, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ann Thorac Surg 89:1410-6. 2010
    ..This study reviews a single institution experience with the Carpentier-Edwards pericardial aortic valve bioprosthesis, concentrating on late outcomes...
  82. ncbi Epicardial cells of human adults can undergo an epithelial-to-mesenchymal transition and obtain characteristics of smooth muscle cells in vitro
    John van Tuyn
    Department of Cardiology, Leiden University Medical Center, Leiden, P O Box 9600, 2300 RC Leiden, The Netherlands
    Stem Cells 25:271-8. 2007
    ....
  83. ncbi YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis
    A W Moore
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Development 126:1845-57. 1999
    ..These data demonstrate a variety of new functions for WT1 and suggest a general requirement for this protein in the formation of organs derived from the intermediate mesoderm...
  84. pmc GATA4 is essential for formation of the proepicardium and regulates cardiogenesis
    Alistair J Watt
    Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53202
    Proc Natl Acad Sci U S A 101:12573-8. 2004
    ..These findings definitively demonstrate a requirement for GATA4 during early cardiac development and identify an essential factor for generation of the proepicardium...
  85. ncbi The role of protein solubilization in antigen removal from xenogeneic tissue for heart valve tissue engineering
    Maelene L Wong
    Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA
    Biomaterials 32:8129-38. 2011
    ..protein solubilization principles were investigated for their ability to reduce antigenicity of bovine pericardium (BP) for heart valve tissue engineering...
  86. ncbi Does glutaraldehyde induce calcification of bioprosthetic tissues?
    A Vincentelli
    Department of Cardiovascular Surgery, Cardiologic Hospital, Lille, France
    Ann Thorac Surg 66:S255-8. 1998
    ..We investigated whether the origin of the tissue, autologous or heterologous, could have a more prominent role in the process of calcification...
  87. pmc Role of spatial dispersion of repolarization in inherited and acquired sudden cardiac death syndromes
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501 1787, USA
    Am J Physiol Heart Circ Physiol 293:H2024-38. 2007
    ..In conclusion, long QT, short QT, Brugada, and catecholaminergic polymorphic VT syndromes are pathologies with very different phenotypes and etiologies, but they share a common final pathway in causing sudden cardiac death...
  88. pmc Equine pericardial roll graft replacement of infected pseudoaneurysm of the aortic arch
    Hiroshi Kubota
    Department of Cardiovascular Surgery, Kyorin University, 6 20 2, Shinkawa, Mitaka, Tokyo, 181 8611, Japan
    J Cardiothorac Surg 7:45. 2012
    ..Because the patients had previously undergone abdominal surgery, the aortic arch were replaced in situ with a branched equine pericardial roll grafts. The patient is alive and well 23 months after the operation...
  89. ncbi Vulnerability of an equine pericardial roll graft to Gram-positive cocci after graft replacement for a ruptured infected abdominal aorta
    Hiroshi Yamamoto
    Department of Cardiovascular Surgery, Akita University School of Medicine, Hondo 1 1 1, Akita 010 8543, Japan
    Interact Cardiovasc Thorac Surg 12:866-8. 2011
    ..We therefore suggest that the infection-resistant property of EPR grafts may be uncertain in patients with postoperative sustained MRSA bacteremia when these grafts are used for arterial reconstruction...
  90. ncbi Cytotoxicity and endothelial cell adhesion of lyophilized and irradiated bovine pericardium modified with silk fibroin and chitosan
    Andrea C D Rodas
    Centro de Biotecnologia, Instituto de Pesquisas Energéticas e Nucleares, Faculdade de Ciências Farmacêuticas da Universidade de São Paulo, Sao Paulo, Brazil
    Artif Organs 35:502-7. 2011
    ..The samples modified with SF/CHIT and electron beam irradiated favored the adhesion and growth of endothelial cells throughout the tissue...
  91. pmc The relationship between epicardial adipose tissue and malnutrition, inflammation, atherosclerosis/calcification syndrome in ESRD patients
    Kultigin Turkmen
    Selcuk University Meram School of Medicine, Department of Nephrology, Konya, Turkey
    Clin J Am Soc Nephrol 6:1920-5. 2011
    ..The relationship between CAD and EAT was shown in patients with high risk of coronary artery disease. In this study, we aimed to investigate the relationship between EAT and MIAC syndrome in ESRD patients...
  92. ncbi Targeted modification of atrial electrophysiology by homogeneous transmural atrial gene transfer
    Kan Kikuchi
    Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circulation 111:264-70. 2005
    ....
  93. pmc WT1 regulates epicardial epithelial to mesenchymal transition through β-catenin and retinoic acid signaling pathways
    Alexander von Gise
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA, USA
    Dev Biol 356:421-31. 2011
    ..Collectively, our study shows that Wt1 regulates epicardial EMT and heart development through canonical Wnt, non-canonical Wnt, and retinoic acid signaling pathways...
  94. ncbi Guidelines on the diagnosis and management of pericardial diseases executive summary; The Task force on the diagnosis and management of pericardial diseases of the European society of cardiology
    Bernhard Maisch
    Department of Internal Medicine Cardiology, Philipps University, Marburg, Germany
    Eur Heart J 25:587-610. 2004
  95. ncbi Epicardial adipose tissue extent: relationship with age, body fat distribution, and coronaropathy
    Alina Silaghi
    INSERM U626, Marseille, France
    Obesity (Silver Spring) 16:2424-30. 2008
    ..01), independently of age and other adiposity measurements. Prospective studies are needed to assess the risk of occurrence/progression of CAD that relate to EAT excess...
  96. ncbi High-concentration glutaraldehyde fixation of bovine pericardium in organic solvent and post-fixation glycine treatment: in vitro material assessment and in vivo anticalcification effect
    Cheul Lee
    Department of Thoracic and Cardiovascular Surgery, Cardiovascular Center, Sejong General Hospital, Bucheon, Republic of Korea
    Eur J Cardiothorac Surg 39:381-7. 2011
    ..of this study was to evaluate the anticalcification effect of glycine treatment and high-concentration GA fixation in organic solvent on GA-fixed bovine pericardium, and to evaluate the possible synergistic effect of combined treatment.
  97. pmc Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations
    Amy M Mellgren
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Circ Res 103:1393-401. 2008
    ..Our data demonstrate that PDGFRbeta is required for the formation of 2 distinct cVSMC populations and that loss of PDGFRbeta-PI3K signaling disrupts epicardial cell migration...
  98. ncbi Increased circulating and epicardial adipose tissue mRNA expression of fibroblast growth factor-21 after cardiac surgery: possible role in postoperative inflammatory response and insulin resistance
    T Kotulak
    Department of Anesthesia and Resuscitation, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Physiol Res 60:757-67. 2011
    ..Muscle FGF-21 mRNA positively correlated with blood glucose levels at the end of the surgery. Our data suggest a possible role of FGF-21 in the regulation of glucose metabolism and insulin sensitivity in surgery-related stress...
  99. pmc Comprehensive gene-expression survey identifies wif1 as a modulator of cardiomyocyte differentiation
    Henk P J Buermans
    Human and Clinical Genetics Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 5:e15504. 2010
    ..In ovo exposure of the HH12 chicken embryonic heart to Wif1 increases the Tbx18-positive cardiac progenitor pool. These data indicate that Wif1 enhances cardiomyogenesis...
  100. pmc Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells
    Tamar C Katz
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 22:639-50. 2012
    ....
  101. pmc Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes
    Bin Zhou
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Mol Cell Cardiol 52:43-7. 2012
    ..This article is part of a Special Issue entitled 'Possible Editorial'...

Research Grants62

  1. A Prospective Study of Adiposity and Subclinical Coronary Artery Disease
    CHRISTINA LYNN WASSEL; Fiscal Year: 2010
    ..e. in the liver, pericardium and muscle) is associated with severe insulin resistance and diabetes...
  2. Tissue Engineered Aortic Heart Valves: Scaffolds and Stem Cells
    DAN TEODOR SIMIONESCU; Fiscal Year: 2013
    ..Aim 1, collagen layers to be used as fibrosa and ventricularis layers will be prepared from decellularized pericardium and lightly cross-linked to allow for controlled biodegradation...
  3. Complex Ventral Hernia Repair
    HOBART WHITAKER HARRIS; Fiscal Year: 2013
    ..prosthetics, derived from collagen-rih porcine, bovine or human tissues such as skin, intestinal submucosa or pericardium, are available for the one-stage repair of complex ventral hernias...
  4. Device for Surgical Adhesion Prevention
    REKHA BANSAL; Fiscal Year: 2010
    ..After surgery, fibrous adhesions form in the peritoneum, central nervous system, pericardium, pleura and synovium...
  5. Cilia in cardiac morphogenesis
    Martina Brueckner; Fiscal Year: 2013
    ..exert their effect by using Cre-lox technology to delete cilia specifically from the epicardium, endocardium, pericardium and anterior heart field. Finally, in Spec. Aim 3 we will seek to define how cardiac cilia direct morphogenesis...
  6. Ectopic Fat, Adipocytokines, and Atherosclerosis in Postmenopausal Women
    Rachel P Wildman; Fiscal Year: 2010
    ..To examine the crosssectional relationships between fat in different locations (liver, epicardium, pericardium) with cardiometabolic risk factors, adipocytokines, and subclinical atherosclerosis;2...
  7. Robotic Crawler for Epicardial Interventions
    Marco A Zenati; Fiscal Year: 2013
    ..entering the pleural space by developing "HeartLander", a tethered miniature robotic crawler that enters the pericardium via subxiphoid incision, attaches itself directly to the surface of the beating heart, moves to the desired ..
  8. Amniotic Membrane versus Pericardium in Reducing Glaucoma Drainage Tube Exposure
    HOSAM EL SHEHA; Fiscal Year: 2013
    ..infection, the implanted GDD tube must be covered by a patch graft traditionally made of either donor sclera or pericardium. However, these patch grafts still carry a high rate of progressive thinning and erosion, a complication that ..
  9. Biophysics of Acupuncture: Electrical Properties of Loose Connective Tissue
    Andrew Ahn; Fiscal Year: 2009
    ..pilot study conducted by the candidate indicates that electrical impedance of connective tissue associated with Pericardium Meridian is significantly lower compared to parallel muscle-control tissue...
  10. Surgical Planning Tool for Aortic Valve Reconstruction
    Pedro J del Nido; Fiscal Year: 2013
    ..The main goal of AVre is to repair the geometry of the valve leaflets using non-leaflet tissue (pericardium treated with gluteraldehyde) to generate valve closure during diastole...
  11. STUDY OF DEXAMETHASONE IN NEONATAL LUPUS CHB
    Jill Buyon; Fiscal Year: 2004
    ..It has been proposed that global inflammation of the working myocardium and surrounding pericardium may precede or accompany AV nodal injury...
  12. Xenogeneic Scaffolds for Heart Valve Tissue Engineering
    LEIGH GARETH GRIFFITHS; Fiscal Year: 2013
    ..Although replacement of the diseased valve with a xenogeneic glutaraldehyde- fixed valve (e.g., bovine pericardium (BP)) dramatically improves short term outcome, long term immune mediated attack results in calcification and ..
  13. Development of a TAVI Device with a Reduced Crossing Profile
    Todd N McAllister; Fiscal Year: 2013
    ..of the crossing profile (diameter) comes from the cusps themselves, which are comprised of relatively thick pericardium derived from animal sources...
  14. SYSTOLIC MECHANICS OF THE FAILING RIGHT VENTRICLE
    Donald Glower; Fiscal Year: 1999
    ..dysfunction and left ventricular contractility during right ventricular failure, and the influence of the pericardium upon right ventricular dysfunction...
  15. RIGHT VENTRICULAR FUNCTION
    WILLIAM SANTAMORE; Fiscal Year: 1991
    ..at least half of right ventricular systolic function can be attributed to the left ventricle; Removing the pericardium will reduce left ventricular assistance; and, Regional ischemia will alter left ventricular assistance...
  16. Amniotic Membrane Patch Graft to Cover Glaucoma Drainage Tube
    HOSAM EL SHEHA; Fiscal Year: 2009
    ..to serious eye infection, the implanted GDD tube has to be covered by a patch graft made of donor sclera or pericardium. However, such a patch graft still carries a high rate of progressive thinning and erosion, a complication that ..
  17. The Monolithic Fetal Pacemaker: Prototype and Deployment
    DANIEL ZAVITZ; Fiscal Year: 2001
    ..The pacemaker is novel because it employs an intrapleural electrode to pace heart through the pericardium, because it uses an extraordinary pathway of current passage, traversing fetal skin, and because its low ..
  18. BIOELASTIC MATERIAL DEVELOPMENT AS ARTIFICAL PERICARDIA
    BETTY COX; Fiscal Year: 1992
    ..Adapted from investigator's abstract): The long term objective of this proposal is to develop a synthetic pericardium for use following open heart surgical procedures and in the use of a total artificial heart bridge to ..
  19. MOUSE MODELS TO STUDY MULIBREY NANISM
    Juan Zapata; Fiscal Year: 2005
    ..of prenatal onset, hypoplasia of several endocrine glands with consequent hormonal deficiency, constrictive pericardium, hepatomegaly, hydrocephaloid skull, muscle hypotonia and susceptibility to develop ovarian and Wilm's tumors...
  20. VENTRICULAR SYSTOLIC INTERACTIONS DURING HEART FAILURE
    David Farrar; Fiscal Year: 1993
    ..steady-state normal beats, under conditions of varying preload and afterload, and with and without the pericardium. The LV to RV pressure gain (Gplr) and flow gain (Gflr) will be calculated as the instantaneous ratios of ..
  21. ASPECTS OF DIASTOLIC FUNCTION IN THE HEART
    Martin LeWinter; Fiscal Year: 1993
    ..contact forces with flat balloons and in addition by using sonomicrometry to measure localized areas of the pericardium. In a second portion of this project, I will test the hypothesis that the pericardium is a determinant of early ..
  22. PLEURAL LIQUID EXCHANGE AND LUNG MECHANICS
    STEPHEN LAI FOOK; Fiscal Year: 2007
    ..A specific objective is to develop a method to separate passive from active transport properties of pericardium and diaphragm, tissues that have both mesothelium and interstitium.
  23. Patterns of gene expression in Mulibrey Nanism
    Juan Zapata; Fiscal Year: 2005
    ..Severe growth failure of prenatal onset, constrictive pericardium with consequent hepatomegaly, hypoplasia of several endocrine glands with consequent hormonal deficiency, ..
  24. CLONING OF THE SEROTONIN 5-HT 1P RECEPTOR
    Theresa Branchek; Fiscal Year: 1990
    ..In addition, 5-HT like binding sites have been discovered in the pericardium and endocardium of the heart, the innervation of the skin, and on portions of the cerebral vasculature where ..
  25. Myocardial Replacement with Acellular Porcine Submucosa
    Keith Robinson; Fiscal Year: 2004
    ..g., glutaraldehyde-fixed bovine pericardium)...
  26. CARDIOPULMONARY REFLEXES AND THEIR ANATOMICAL BASIS
    DAVID KOSTREVA; Fiscal Year: 1980
    ..These receptors are located within the atria, ventrals, pericardium, lung vasculature and lung parenchyma...
  27. Imaging the vascular response to implants
    Jennifer Barton; Fiscal Year: 2006
    ..polytetrafluroethylene (ePTFE) implants will be placed in rabbit eyes with or without patches of ePTFE, pericardium or a scaffold-based three-dimensional human fibroblast culture...
  28. Pericardial fat and subclinical and clinical measures of coronary heart disease
    Jingzhong Ding; Fiscal Year: 2009
    ..Given the health impact of coronary heart disease, there is a pressing need to examine the relationship between pericardial fat and coronary heart disease. ..
  29. The Role of Cartilage Link Protein 1 (Crtl1) in Heart Development
    ARNO WESSELS; Fiscal Year: 2010
    ..Understanding the role of Crtl1, and Crtl1-associated mechanisms, in heart development may further our knowledge of the etiology of a variety of these malformations including the mechanisms that lead to muscular septal defects. ..
  30. Ethanol Effects of SR Ca2+ Release in Cardiac Myocytes
    J Wasserstrom; Fiscal Year: 2005
    ....
  31. Controlled Reperfusion for Whole Body Ischemic Injury
    Gerald Buckberg; Fiscal Year: 2005
    ..If this novel method of management is correct, the scheme of diagnosis and management of this almost always fatal cardiac arrest complex will change markedly. ..
  32. Visualizing the Substrate for Sudden Cardiac Death
    Vivek Reddy; Fiscal Year: 2006
    ..abstract_text> ..
  33. Invasive Assessment of the Coronary Microcirculation
    William Fearon; Fiscal Year: 2008
    ..abstract_text> ..
  34. ENHANCED DURABILITY OF BIOPROSTHETIC HEART VALVES
    Michael Sacks; Fiscal Year: 2004
    ..Determine how chemical treatment alters cuspal layer micromechanics. 2. Quantify PBHV cuspal deformation during the cardiac cycle. 3. Determine how long-term cyclic fatigue alters PBHV later structure and mechanical properties. ..
  35. Regulation of Coronary Vessel Assembly and Growth
    Robert Tomanek; Fiscal Year: 2007
    ..Since cardiac development depends on timely and adequate vascularization, an understanding of coronary vasculogenesis and angiogenesis will provide an important foundation for our understanding of cardiac defects. ..
  36. ANGIOGENIC THERAPY FOR INFARCTED AND ISCHEMIC HEART
    Robert Tomanek; Fiscal Year: 2003
    ..Such interventions have a number of advantages over more invasive interventions, e.g., the delivery of oxogenous growth factors or gene therapy. ..
  37. Substrate Mapping & Ablation of Ventricular Tachycardia
    Vivek Reddy; Fiscal Year: 2006
    ..abstract_text> ..
  38. MECHANISMS FOR MAINTENANCE OF VENTRICULAR FIBRILLATION
    Jack Rogers; Fiscal Year: 2006
    ..This project will develop single anld multisite pacing circuits and evaluate their performance using panoramic optical mapping of isolated perfused swine hearts. ..
  39. ATRIAL FIBRILLATION: MECHANISMS AND PREVENTION
    Michael Rosen; Fiscal Year: 2003
    ....
  40. Retinoic Acid Regulation of Erythropoiesis
    Henry Sucov; Fiscal Year: 2004
    ..In this Aim, I will test the hypothesis that a transition occurs in definitive erythropoiesis from regulation of Epo gene expression retinoic acid and RXRalpha to regulation by HNF4. ..
  41. The Cardiac Atlas Project: Establishment of a Cardiac MRI Database.
    ALISTAIR ANDREW YOUNG; Fiscal Year: 2010
    ..By pooling data from many studies into a single resource, researchers will be able to perform standardized comparisons across many patient groups, in order to better predict and evaluate the effects of disease and treatment. ..
  42. Mechanisms of ECM Scaffold Remodeling
    Stephen Badylak; Fiscal Year: 2006
    ..The work will be conducted by an experienced interdisciplinary team of scientists and a timeline is presented for completion of the work. ..
  43. MR of Heart Iron: T2*/T2 Calibration & Application
    Dudley Pennell; Fiscal Year: 2006
    ..These centers are Philadelphia (USA), Cagliari (Italy), Athens (Greece), Nicosia (Cyprus), Mumbai (India) and Singapore. ..
  44. Regional Dysfunction by MRI in Incident Heart Failure
    Joao Lima; Fiscal Year: 2009
    ..These findings will be pivotal to the design of future strategies to forestall progressive myocardial dysfunction and prevent the development of heart failure. ..
  45. GENERAL CLINICAL RESEARCH CENTER
    Karen Antman; Fiscal Year: 2008
    ..abstract_text> ..
  46. Oropharyngeal Bolus Flow Dynamics
    Mark Nicosia; Fiscal Year: 2008
    ..This will lead naturally to an optimization tool, which could be added to the current arsenal of tools with which to analyze available diagnostic and therapeutic procedures and to develop new ones. [unreadable] [unreadable] [unreadable]..
  47. Novel Cancer Targeting Mechanism for Nuclear Imaging
    Benjamin Franc; Fiscal Year: 2006
    ..In summary, the targeting strategy developed in this project aims to open the door to novel cancer targets for nuclear imaging. ..
  48. Cellular Remodeling of ECM Scaffolds
    Stephen Badylak; Fiscal Year: 2009
    ..We have identified clearly defined specific aims with quantifiable end points and an efficient three year timeline to conduct this work. ..
  49. ANTIFIBRILLATORY MECHANISMS OF INTRAPERICARDIAL AGENTS
    RICHARD VERRIER; Fiscal Year: 2004
    ..Ultimately, the proposed studies could lead to improved therapeutic approaches for suppression of life-threatening arrhythmias. ..
  50. Iron and Atherosclerosis
    Subha Raman; Fiscal Year: 2006
    ..Subgroup analyses will include comparison of the presence of iron symptomatic versus asymptomatic patients and women versus age-matched men. ..
  51. TRANSMEMBRANE POTENTIAL MAPPING OF DEFIBRILLATION
    STEPHEN KNISLEY; Fiscal Year: 2002
    ..The project will yield insights that are necessary in order to advance understanding of cellular bases of defibrillation. ..
  52. ORIGIN OF CELLS THAT REPOPULATE RESORBABLE ECM SCAFFOLDS
    Stephen Badylak; Fiscal Year: 2001
    ..abstract_text> ..
  53. SHORT-TERM RESEARCH TRAINING FOR MINORITY STUDENTS
    Charles Wood; Fiscal Year: 2008
    ..The emphasis of this training program in the next five years will be to significantly expand the students' horizons and to recruit students into basic biomedical science. ..
  54. Cardiovascular Development and Disease in the Young
    Michael Rosen; Fiscal Year: 2008
    ..abstract_text> ..
  55. THE ROLE OF SRF IN CARDIAC FUNCTION AND DEVELOPMENT
    RAVINDRA MISRA; Fiscal Year: 2005
    ..These studies will both elucidate the mechanisms by which SRF functions in heart and will establish powerful new methodologies for studying heart formation and function. ..
  56. TRANSMURAL DEFORMATION
    Jeffrey Omens; Fiscal Year: 2008
    ..We will test the hypothesis that minimizing the 'prestretch' tissue area can be used as an algorithm to select pacing sites which improve global and regional function in the failing heart. ..
  57. Pressure and Flow-Induced Remodeling of Coronary Arteries
    Ghassan S Kassab; Fiscal Year: 2010
    ..The long-term goal of this research is to develop optimal therapies to restore the oxidative balance in CAD. ..
  58. A Validated Micro-Structural Mechanical Model of Coronary Arteries
    Ghassan S Kassab; Fiscal Year: 2010
    ....
  59. 13C and 15N MRS Study of glutamate control in epilepsy
    Brian Ross; Fiscal Year: 2009
    ..Together these studies will contribute to a better understanding of the regulatory events of the GLN/GLU cycle in KA and increase potential to replace surgical management of temporal lobe epilepsy. ..
  60. Transcriptional Control of Early Coronary Vascular Development
    RAVINDRA P MISRA; Fiscal Year: 2010
    ....
  61. Microangiectasia Regulation of Lymphocyte Migration
    Steven Mentzer; Fiscal Year: 2006
    ..abstract_text> ..