mitral valve

Summary

Summary: The valve between the left atrium and left ventricle of the heart.

Top Publications

  1. ncbi Surgical repair of congenital mitral valve malformations in infancy and childhood: a single-center 36-year experience
    Giovanni Stellin
    Pediatric and Congenital Cardiac Surgery Unit, University of Padua Medical School, Padua, Italy
    J Thorac Cardiovasc Surg 140:1238-44. 2010
  2. pmc TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome
    Connie M Ng
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Invest 114:1586-92. 2004
  3. ncbi Cardiovascular morbidity and mortality in community-dwelling elderly individuals with calcification of the fibrous skeleton of the base of the heart and aortosclerosis (The Cardiovascular Health Study)
    Eddy Barasch
    Department of Research and Education, St Francis Hospital, Roslyn, New York, USA
    Am J Cardiol 97:1281-6. 2006
  4. ncbi TGF-beta1 expression and atrial myocardium fibrosis increase in atrial fibrillation secondary to rheumatic heart disease
    Hua Xiao
    Department of Cardiology, First Affiliated Hospital, Chongqing Medical University, Chongqing, China
    Clin Cardiol 33:149-56. 2010
  5. ncbi Heritability of premature mitral valve disease in Cavalier King Charles spaniels
    Tom Lewis
    Kennel Club Genetics Centre at the Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK
    Vet J 188:73-6. 2011
  6. ncbi Acute and 12-month results with catheter-based mitral valve leaflet repair: the EVEREST II (Endovascular Valve Edge-to-Edge Repair) High Risk Study
    Patrick L Whitlow
    Cleveland Clinic, Ohio 44195, USA
    J Am Coll Cardiol 59:130-9. 2012
  7. ncbi Use of real-time 3-dimensional transthoracic echocardiography in the evaluation of mitral valve disease
    Lissa Sugeng
    Section of Cardiology, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Am Soc Echocardiogr 19:413-21. 2006
  8. ncbi Association between antibodies against calcifying nanoparticles and mitral annular calcification
    Basar Candemir
    Department of Cardiology, Ankara University, School of Medicine, Ankara, Turkey
    J Heart Valve Dis 19:745-52. 2010
  9. ncbi Mechanism of dynamic regurgitant orifice area variation in functional mitral regurgitation: physiologic insights from the proximal flow convergence technique
    J Hung
    Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Boston 02114, USA
    J Am Coll Cardiol 33:538-45. 1999
  10. ncbi Multivariable prediction of in-hospital mortality associated with aortic and mitral valve surgery in Northern New England
    Edward R Nowicki
    Dartmouth Medical School, Hanover, New Hampshire 03756, USA
    Ann Thorac Surg 77:1966-77. 2004

Detail Information

Publications378 found, 100 shown here

  1. ncbi Surgical repair of congenital mitral valve malformations in infancy and childhood: a single-center 36-year experience
    Giovanni Stellin
    Pediatric and Congenital Cardiac Surgery Unit, University of Padua Medical School, Padua, Italy
    J Thorac Cardiovasc Surg 140:1238-44. 2010
    We sought to evaluate the results of surgical repair and determine predictors for the late outcome of congenital mitral valve dysplasia.
  2. pmc TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome
    Connie M Ng
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Invest 114:1586-92. 2004
    b>Mitral valve prolapse (MVP) is a common human phenotype, yet little is known about the pathogenesis of this condition...
  3. ncbi Cardiovascular morbidity and mortality in community-dwelling elderly individuals with calcification of the fibrous skeleton of the base of the heart and aortosclerosis (The Cardiovascular Health Study)
    Eddy Barasch
    Department of Research and Education, St Francis Hospital, Roslyn, New York, USA
    Am J Cardiol 97:1281-6. 2006
    ..Elderly patients with these findings represent a high-risk group and may require close medical attention...
  4. ncbi TGF-beta1 expression and atrial myocardium fibrosis increase in atrial fibrillation secondary to rheumatic heart disease
    Hua Xiao
    Department of Cardiology, First Affiliated Hospital, Chongqing Medical University, Chongqing, China
    Clin Cardiol 33:149-56. 2010
    ..Transforming growth factor-beta1 (TGF-beta1) was one of the main factors for accelerating collagen production. The contribution of TGF-beta1 in the pathogenesis of AF needs further investigation...
  5. ncbi Heritability of premature mitral valve disease in Cavalier King Charles spaniels
    Tom Lewis
    Kennel Club Genetics Centre at the Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK
    Vet J 188:73-6. 2011
    ..all dogs registered from the mid 1980s to September 2007 was used to estimate variance parameters of premature mitral valve disease (MVD)...
  6. ncbi Acute and 12-month results with catheter-based mitral valve leaflet repair: the EVEREST II (Endovascular Valve Edge-to-Edge Repair) High Risk Study
    Patrick L Whitlow
    Cleveland Clinic, Ohio 44195, USA
    J Am Coll Cardiol 59:130-9. 2012
    ....
  7. ncbi Use of real-time 3-dimensional transthoracic echocardiography in the evaluation of mitral valve disease
    Lissa Sugeng
    Section of Cardiology, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Am Soc Echocardiogr 19:413-21. 2006
    Three-dimensional (3D) echocardiography (3DE) provides unique orientations of the mitral valve (MV) not obtainable by routine 2-dimensional echocardiography...
  8. ncbi Association between antibodies against calcifying nanoparticles and mitral annular calcification
    Basar Candemir
    Department of Cardiology, Ankara University, School of Medicine, Ankara, Turkey
    J Heart Valve Dis 19:745-52. 2010
    ..The study aim was to evaluate a possible association between mitral annular calcification (MAC) and CNP infection...
  9. ncbi Mechanism of dynamic regurgitant orifice area variation in functional mitral regurgitation: physiologic insights from the proximal flow convergence technique
    J Hung
    Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Boston 02114, USA
    J Am Coll Cardiol 33:538-45. 1999
    ..We used the Doppler proximal flow convergence technique as a physiologic tool to explore the effects of the time courses of mitral annular area and transmitral pressure on dynamic changes in regurgitant orifice area...
  10. ncbi Multivariable prediction of in-hospital mortality associated with aortic and mitral valve surgery in Northern New England
    Edward R Nowicki
    Dartmouth Medical School, Hanover, New Hampshire 03756, USA
    Ann Thorac Surg 77:1966-77. 2004
    Predicting risk for aortic and mitral valve surgery is important both for informed consent of patients and objective review of surgical outcomes...
  11. ncbi Quantitative determinants of the outcome of asymptomatic mitral regurgitation
    Maurice Enriquez-Sarano
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    N Engl J Med 352:875-83. 2005
    ..The clinical outcome of asymptomatic mitral regurgitation is poorly defined, and the treatment is uncertain. We studied the effect on the outcome of quantifying mitral regurgitation according to recent guidelines...
  12. ncbi Percutaneous mitral valve repair using the edge-to-edge technique: six-month results of the EVEREST Phase I Clinical Trial
    Ted Feldman
    Evanston Hospital, Cardiology Division Burch 300, Evanston, Illinois 60201, USA
    J Am Coll Cardiol 46:2134-40. 2005
    This study sought to evaluate the clinical results of a percutaneous approach to mitral valve repair for mitral regurgitation (MR).
  13. ncbi Quantitative assessment of velocities of the annulus of the left atrioventricular valve and left ventricular free wall in healthy cats by use of two-dimensional color tissue Doppler imaging
    Valerie Chetboul
    Cardiology Unit of Alfort, National Veterinary School of Alfort, 7 Avenue du General de Gaulle, 94704 Maisons Alfort cedex, France
    Am J Vet Res 67:250-8. 2006
    ..To analyze velocities of the annulus of the left atrioventricular valve and left ventricular free wall (LVFW) in a large population of healthy cats by use of 2-dimensional color tissue Doppler imaging (TDI)...
  14. ncbi Performance of bioprostheses and mechanical prostheses assessed by composites of valve-related complications to 15 years after mitral valve replacement
    W R E Jamieson
    University of British Columbia, Vancouver, British Columbia, Canada
    J Thorac Cardiovasc Surg 129:1301-8. 2005
    ..The purpose of this study was to compare valve-related reoperation, morbidity (permanent impairment), and mortality between bioprostheses and mechanical prostheses for mitral valve replacement.
  15. ncbi Mitral valve repair and replacement for rheumatic disease
    T M Yau
    Division of Cardiovascular Surgery, Toronto General Hospital, University Health Network, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 119:53-60. 2000
    b>Mitral valve repair may be technically feasible in patients with suitable anatomy, but the appropriateness of repair for rheumatic disease remains controversial...
  16. ncbi Percutaneous mitral annuloplasty: an anatomic study of human coronary sinus and its relation with mitral valve annulus and coronary arteries
    Daniele Maselli
    Cardio Thoracic Department, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Circulation 114:377-80. 2006
    ..percutaneous techniques consisting of delivery into the coronary sinus (CS) of devices intended to shrink the mitral valve annulus have recently been tested in animal models...
  17. ncbi Minimally invasive mitral valve surgery: a systematic review and meta-analysis
    Paul Modi
    East Carolina Heart Institute, Greenville, NC 27834, USA
    Eur J Cardiothorac Surg 34:943-52. 2008
    The mitral valve has been traditionally approached through a median sternotomy...
  18. ncbi Recurrent mitral regurgitation and risk factors for early and late mortality after mitral valve repair for functional ischemic mitral regurgitation
    Traves D Crabtree
    Division of Cardiothoracic Surgery, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    Ann Thorac Surg 85:1537-42; discussion 1542-3. 2008
    ..Data regarding risk factors, progression of MR, and cause of death in this subgroup are limited...
  19. ncbi Mitral valve abnormalities identified by cardiovascular magnetic resonance represent a primary phenotypic expression of hypertrophic cardiomyopathy
    Martin S Maron
    Hypertrophic Cardiomyopathy Center, Division of Cardiology, Tufts Medical Center, No 70, 800 Washington St, Boston, MA 02111, USA
    Circulation 124:40-7. 2011
    Whether morphological abnormalities of the mitral valve represent part of the hypertrophic cardiomyopathy (HCM) disease process is unresolved...
  20. ncbi Effects of giant left atrium on thromboembolism after mitral valve replacement
    Veysel Kutay
    Cardiovascular Surgery Department, Van Yuksek Ihtisas Hospital, Van, Turkey
    Asian Cardiovasc Thorac Ann 13:107-11. 2005
    ..5 cm) after mitral valve replacement...
  21. pmc Cardiac transgenic matrix metalloproteinase-2 expression induces myxomatous valve degeneration: a potential model of mitral valve prolapse disease
    Rajeev Mahimkar
    Department of Medicine, SFVAMC University of California San Francisco, San Francisco, CA, USA
    Cardiovasc Pathol 18:253-61. 2009
    Myxomatous mitral valve "degeneration" with prolapse (MVP) is the most frequent form of nonischemic mitral valve disease...
  22. ncbi Mitral valve replacement is a viable alternative to mitral valve repair for ischemic mitral regurgitation: a case-matched study
    Vincent Chan
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Ann Thorac Surg 92:1358-65; discussion 1365-6. 2011
    Comparisons of mitral valve repair with mitral valve replacement for ischemic mitral regurgitation (IMR) have been limited by differences in preoperative and operative characteristics of patients undergoing these two types of surgical ..
  23. ncbi Combining robotic mitral valve repair and microwave atrial fibrillation ablation: techniques and initial results
    Clifton C Reade
    Division of Cardiothoracic and Vascular Surgery, The Brody School of Medicine at East Carolina University, Greenville, North Carolina 27858, USA
    Ann Thorac Surg 79:480-4. 2005
    ..Previously, mitral valve repairs (MVP) with atrial fibrillation ablation have been performed through sternotomy...
  24. ncbi Ablation of atrial fibrillation with concomitant cardiac surgery
    A Marc Gillinov
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Semin Thorac Cardiovasc Surg 19:25-32. 2007
    Atrial fibrillation is present in approximately 35% of patients presenting for mitral valve surgery and in 1 to 6% of adult patients undergoing other forms of cardiac surgery...
  25. ncbi Preoperative posterior leaflet angle accurately predicts outcome after restrictive mitral valve annuloplasty for ischemic mitral regurgitation
    Julien Magne
    Quebec Heart Institute, Faculty of Medicine, Laval University, Quebec, Canada, G1V 4G5
    Circulation 115:782-91. 2007
    Ischemic mitral regurgitation (MR) often persists after restrictive mitral valve annuloplasty, in which case it is associated with worse clinical outcomes...
  26. ncbi Chronic ischaemic mitral regurgitation. Current treatment results and new mechanism-based surgical approaches
    Wobbe Bouma
    Department of Cardiothoracic Surgery, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Cardiothorac Surg 37:170-85. 2010
    ..left ventricular (LV) remodelling with papillary muscle displacement and apical tenting of the mitral valve leaflets...
  27. ncbi The impact of patient-prosthesis mismatch on late outcomes after mitral valve replacement
    Buu Khanh Lam
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 133:1464-73. 2007
    The incidence of patient-prosthesis mismatch after mitral valve replacement and its effect on late outcomes have remained unclear...
  28. ncbi Normative reference values for the tissue Doppler imaging parameters of left ventricular function: a population-based study
    Navtej S Chahal
    Department of Cardiovascular Medicine, Northwick Park Hospital, Harrow HA1 3UJ, UK
    Eur J Echocardiogr 11:51-6. 2010
    ..Tissue Doppler imaging (TDI) is used routinely to quantify left ventricular function and filling pressure. However, there remains a lack of percentile-based normative reference values for these clinically important parameters...
  29. ncbi Staphylococcus hominis native mitral valve bacterial endocarditis (SBE) in a patient with hypertrophic obstructive cardiomyopathy
    Burke A Cunha
    Winthrop University Hospital, Mineola, New York State University of New York School of Medicine, Stony Brook, New York, USA
    Heart Lung 36:380-2. 2007
    ..There has been only one reported case of non-mitral valve IE due to CoNS in a patient with hypertrophic obstructive cardiomyopathy...
  30. ncbi Quantitation of mitral valve tenting in ischemic mitral regurgitation by transthoracic real-time three-dimensional echocardiography
    Nozomi Watanabe
    Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
    J Am Coll Cardiol 45:763-9. 2005
    ....
  31. ncbi Percutaneous transcatheter mitral valve repair: a classification of the technology
    Paul T L Chiam
    Department of Cardiology, National Heart Centre, Singapore, Singapore
    JACC Cardiovasc Interv 4:1-13. 2011
    Surgical treatment of mitral regurgitation (MR) has evolved from mitral valve replacement (MVR) to repair (MVR(e)), because MVR(e) produces superior long-term outcomes...
  32. ncbi Mitral valve reconstruction in a pediatric population: late clinical results and predictors of long-term outcome
    Alfred E Wood
    Departments of Cardiothoracic Surgery and Cardiology, Our Lady s Hospital for Sick Children, 69 Eccles Street, Crumlin, Dublin 7, Ireland
    J Thorac Cardiovasc Surg 130:66-73. 2005
    Pediatric mitral valve anomalies present complex management challenges to the surgeon, who may have to choose between valve replacement or repair...
  33. ncbi The evolution from surgery to percutaneous mitral valve interventions: the role of the edge-to-edge technique
    Francesco Maisano
    Department of Cardiovascular Medicine, San Raffaele Hospital, Via Olgettina 60, Milan, Italy
    J Am Coll Cardiol 58:2174-82. 2011
    The edge-to-edge technique is a versatile procedure for mitral valve repair. Its technical simplicity has been the prerequisite for the development of a number of transcatheter technologies to perform percutaneous mitral valve repair...
  34. ncbi Reoperative mitral valve surgery by the port access minithoracotomy approach is safe and effective
    Steven R Meyer
    Division of Cardiovascular Surgery, Penn Presbyterian Medical Center, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 87:1426-30. 2009
    Reoperative mitral valve (MV) surgery through sternotomy can be technically challenging...
  35. ncbi Mitral valve annuloplasty and papillary muscle relocation oriented by 3-dimensional transesophageal echocardiography for severe functional mitral regurgitation
    Khalil Fattouch
    Department of Cardiac Surgery, University of Palermo, Palermo, Italy
    J Thorac Cardiovasc Surg 143:S38-42. 2012
    The study of the mitral valve apparatus and its modifications during functional mitral regurgitation (FMR) is better revealed by 3-dimensional (3D) transesophageal echocardiography (TOE)...
  36. ncbi Mitral valve surgery in the adult Marfan syndrome patient
    Sunil K Bhudia
    Marfan Syndrome and Connective Tissue Disorder Clinic, Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 81:843-8. 2006
    Because mitral valve dysfunction in adults with Marfan syndrome is poorly characterized, this study compares mitral valve pathophysiology and morphology with that of myxomatous mitral disease, documents types of mitral valve operations, ..
  37. ncbi Mitral valve and tricuspid valve blood flow: accurate quantification with 3D velocity-encoded MR imaging with retrospective valve tracking
    Jos J M Westenberg
    Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Radiology 249:792-800. 2008
    ....
  38. ncbi Kidney function and aortic valve and mitral annular calcification in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Joachim H Ix
    Department of Medicine, University of California, San Francisco, CA 94143 0532, USA
    Am J Kidney Dis 50:412-20. 2007
    ..Whether less severe kidney dysfunction is associated with AVC and MAC is uncertain...
  39. ncbi Progression of isolated tricuspid regurgitation late after mitral valve surgery for rheumatic mitral valve disease
    Chisato Izumi
    Department of Cardiology, Tenri Hospital, Nara, Japan
    J Heart Valve Dis 11:353-6. 2002
    Severe tricuspid regurgitation (TR) may develop late after mitral valve surgery without significant mitral stenosis, regurgitation and other causes of left heart failure...
  40. ncbi Evolution of mitral valve surgery: toward a totally endoscopic approach
    J E Felger
    Department of Surgery, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27858, USA
    Ann Thorac Surg 72:1203-8; discussion 1208-9. 2001
    ..METHODS: Consecutive patients with isolated mitral valve disease underwent either manually directed (n = 55) or voice-activated robotically directed (n = 72) video-..
  41. ncbi Repair of congenital malformations of the mitral valve: early and midterm results
    Edvin Prifti
    G Pasquinucci Hospital, CREAS IFC CNR, Massa, Italy
    Ann Thorac Surg 73:614-21. 2002
    ..to determine early and midterm survival and freedom from reoperation, and to identify the predictors for poor postoperative outcome in children undergoing mitral valve (MV) repair owing to congenital malformations of the mitral valve.
  42. ncbi Mitral annular calcification predicts cardiovascular morbidity and mortality: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Circulation 107:1492-6. 2003
    ..Prospective data are limited on the relation of MAC with CVD morbidity and mortality...
  43. ncbi Influence of atrial fibrillation on outcome following mitral valve repair
    E Lim
    Department of Cardiothoracic Surgery, Papworth Hospital, Papworth Everard, and the Medical Research Council Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Circulation 104:I59-63. 2001
    BACKGROUND: To investigate the outcome of patients in atrial fibrillation (AF) following mitral valve repair, clinical and echocardiographic follow-up was undertaken in 400 consecutive patients who underwent mitral valvuloplasty from 1987 ..
  44. ncbi Impact of mitral valve annuloplasty on mortality risk in patients with mitral regurgitation and left ventricular systolic dysfunction
    Audrey H Wu
    Division of Cardiology, Department of Internal Medicine, University of Michigan Health Systems, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    J Am Coll Cardiol 45:381-7. 2005
    This study was designed to assess effects of mitral valve annuloplasty (MVA) on mortality in patients with mitral regurgitation (MR) and left ventricular (LV) systolic dysfunction.
  45. ncbi Idiopathic ventricular arrhythmia arising from the mitral annulus: a distinct subgroup of idiopathic ventricular arrhythmias
    Hiroshi Tada
    Division of Cardiology, Gunma Prefectural Cardiovascular Center, Maebashi, Gunma, Japan
    J Am Coll Cardiol 45:877-86. 2005
    ..We sought to clarify the prevalence and characteristics of idiopathic ventricular tachycardia or premature ventricular contraction originating from the mitral annulus (MAVT/PVC)...
  46. pmc Mitral leaflet adaptation to ventricular remodeling: occurrence and adequacy in patients with functional mitral regurgitation
    Miguel Chaput
    Division of Cardiothoracic Surgery and Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circulation 118:845-52. 2008
    ..Our aim was to explore whether adaptive increases in leaflet area occur in patients with functional MR compared with normal subjects and to test the hypothesis that leaflet area influences MR severity...
  47. ncbi Expression of angiotensin II receptors in human left and right atrial tissue in atrial fibrillation with and without underlying mitral valve disease
    Andreas Boldt
    University of Leipzig, Heart Center, Cardiovascular Surgery, Cardiology, Leipzig, Germany
    J Am Coll Cardiol 42:1785-92. 2003
    TIVES: We postulated a change of angiotensin II receptor subtype expression in patients with lone atrial fibrillation (AF) and AF with underlying mitral valve disease (MVD) both compared with sinus rhythm (SR).
  48. ncbi Heart valve sclerosis predicts all-cause and cardiovascular mortality
    Henry Volzke
    Institute for Community Medicine, Ernst Moritz Arndt University Greifswald, Walther Rathenau Str 48, D 17487 Greifswald, Germany
    Atherosclerosis 209:606-10. 2010
    ..We further studied whether a combined presence of AVS and MAC is more strongly associated with mortality than the single items and sought to disclose possible gender differences in the investigated associations...
  49. ncbi Randomized study of surgical isolation of the pulmonary veins for correction of permanent atrial fibrillation associated with mitral valve disease
    Alvaro Albrecht
    Department of Cardiovascular Surgery, Instituto de Cardiologia do Rio Grande do Sul Fundação Universitária de Cardiologia IC FUC, Porto Alegre, Brazil
    J Thorac Cardiovasc Surg 138:454-9. 2009
    Chronic permanent atrial fibrillation is often due to mitral valve disease. The Cox maze procedure is the gold standard for treating this arrhythmia...
  50. ncbi Longitudinal ventricular function: normal values of atrioventricular annular and myocardial velocities measured with quantitative two-dimensional color Doppler tissue imaging
    Nikolay P Nikitin
    Department of Cardiology, University of Hull School of Medicine, Cottingham, Kingston upon Hull, United Kingdom
    J Am Soc Echocardiogr 16:906-21. 2003
    ..The aim of this study was to obtain normal values for atrioventricular annular and regional myocardial velocities using this method...
  51. ncbi Trends in mitral valve surgery in the United States: results from the Society of Thoracic Surgeons Adult Cardiac Surgery Database
    James S Gammie
    Division of Cardiac Surgery, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    Ann Thorac Surg 87:1431-7; discussion 1437-9. 2009
    The purpose of this study is to examine trends in mitral valve (MV) repair and replacement surgery using The Society of Thoracic Surgeons Adult Cardiac Surgery Database (STS ACSD).
  52. ncbi Randomized study of surgery for patients with permanent atrial fibrillation as a result of mitral valve disease
    Gustavo Glotz de Lima
    Department of Electrophysiology, Instituto de Cardiologia do Rio Grande do Sul, Fundação Universitária de Cardiologia, Porto Alegre, Brazil
    Ann Thorac Surg 77:2089-94; discussion 2094-5. 2004
    The Cox Maze procedure has been used to treat atrial fibrillation in patients with mitral valve disease...
  53. ncbi Predictors of residual tricuspid regurgitation after mitral valve surgery
    Katsuhiko Matsuyama
    Department of Cardiovascular Surgery, Tenri Hospital, Tenri, Nara, Japan
    Ann Thorac Surg 75:1826-8. 2003
    Whether preoperative tricuspid regurgitation (TR) will regress or progress late after surgery is unknown. The aim of this study was to evaluate predictors of significant TR late after mitral valve surgery.
  54. pmc Percutaneous mitral annuloplasty for functional mitral regurgitation: results of the CARILLON Mitral Annuloplasty Device European Union Study
    Joachim Schofer
    Medical Care Center Professor Mathey, Professor Schofer Hamburg University Cardiovascular Center Hamburg, Hamburg, Germany
    Circulation 120:326-33. 2009
    ..Percutaneous mitral annuloplasty has the potential to serve as a therapeutic adjunct to standard medical care...
  55. ncbi Valve repair versus valve replacement for degenerative mitral valve disease
    A Marc Gillinov
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 135:885-93, 893.e1-2. 2008
    ..was to identify characteristics differentiating patients undergoing valve replacement versus valve repair for degenerative mitral valve disease and to use this information to compare survival and reoperation after each procedure.
  56. ncbi Minimally invasive versus conventional mitral valve surgery: a propensity-matched comparison
    Lars G Svensson
    Center for Aortic Surgery and Marfan and Connective Tissue Disorder Clinic, The Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, 9500 Euclid Ave Mail Stop J4 1, Cleveland, OH 44195, USA
    J Thorac Cardiovasc Surg 139:926-32.e1-2. 2010
    Less invasive approaches to mitral valve surgery are increasingly used for improved cosmesis; however, few studies have investigated their effect on outcome...
  57. ncbi Early and late outcomes in minimally invasive mitral valve repair: an eleven-year experience in 707 patients
    R Scott McClure
    Brigham and Women s Hospital, Division of Cardiac Surgery, Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
    J Thorac Cardiovasc Surg 137:70-5. 2009
    This study analyzes a single institution experience with minimally invasive mitral valve repair and evaluates long-term surgical outcomes of morbidity, mortality, and rates of reoperation...
  58. ncbi Prediction of operative mortality after valve replacement surgery
    F H Edwards
    Division of Cardiothoracic Surgery, University of Florida Health Science Center, Jacksonville 32209 6511, USA
    J Am Coll Cardiol 37:885-92. 2001
    ..We sought to develop national benchmarks for valve replacement surgery by developing statistical risk models of operative mortality...
  59. ncbi Prediction of outcome in patients undergoing surgery for severe tricuspid regurgitation following mitral valve surgery and role of tricuspid annular systolic velocity
    Dong A Kwon
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Am J Cardiol 98:659-61. 2006
    ..to postoperative clinical outcome in patients who undergo surgery for severe tricuspid regurgitation after mitral valve surgery. Eighteen patients (2 men, 16 women; mean age 58 years) were prospectively enrolled...
  60. ncbi Mitral valve operation via Port Access versus median sternotomy
    D D Glower
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Eur J Cardiothorac Surg 14:S143-7. 1998
    The advantages and disadvantages of minimally invasive Port Access mitral valve operation have not been defined relative to standard median sternotomy...
  61. ncbi Cellular mechanisms in mitral valve disease
    Kareem Salhiyyah
    Imperial College London, Heart Science Centre, Harefield, Middlesex, UB9 6JH, UK
    J Cardiovasc Transl Res 4:702-9. 2011
    The mitral valve is a living structure comprised of specific structural components which contain a heterogeneous population of cells...
  62. pmc Heat shock proteins in stabilization of spontaneously restored sinus rhythm in permanent atrial fibrillation patients after mitral valve surgery
    Hailong Cao
    Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd, Nanjing, 210029, China
    Cell Stress Chaperones 16:517-28. 2011
    A spontaneously restored sinus rhythm in permanent atrial fibrillation patients has been often observed after mitral valve (MV) surgery, but persisting duration in sinus rhythm varies from patient to patient...
  63. ncbi Surgery for atrial fibrillation in patients with mitral valve disease: results at five years from the International Registry of Atrial Fibrillation Surgery
    Joao Melo
    Hospital Sta Cruz, Carnaxide, Portugal
    J Thorac Cardiovasc Surg 135:863-9. 2008
    We sought to assess the clinical and survival benefit of atrial fibrillation surgery in patients submitted to mitral valve surgery after stabilization of postoperative rhythm at 1 year.
  64. ncbi Reduction of hemolysis without reoperation following mitral valve repair
    Masaru Inoue
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Circ J 67:799-801. 2003
    Hemolytic anemia following mitral valve repair and annular ring placement is uncommon compared with mitral valve replacement...
  65. ncbi Midterm results after stentless mitral valve replacement
    Thomas Walther
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum, Leipzig, Germany
    Circulation 108:II85-9. 2003
    To analyze the midterm clinical results after stentless mitral valve (SMV) replacement.
  66. ncbi Surgical management of acute mitral valve regurgitation due to post-infarction papillary muscle rupture
    Reza Tavakoli
    Department of Cardiovascular Surgery, University Hospital, Zurich, Switzerland
    J Heart Valve Dis 11:20-5; discussion 26. 2002
    ..Data relating to early and late survival after emergency mitral valve surgery and concomitant complete coronary artery revascularization in this patient population were analyzed.
  67. ncbi Echocardiographic assessment of left ventricular geometry and the mitral valve apparatus in cats with hypertrophic cardiomyopathy
    Karsten Schober
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon L Tharp Street, Columbus, OH 43210, USA
    J Vet Cardiol 12:1-16. 2010
    This retrospective study addressed the general hypothesis that abnormalities of the mitral valve apparatus are common in cats with idiopathic hypertrophic cardiomyopathy (HCM) and contribute to dynamic obstruction of the left ventricular ..
  68. ncbi Dabigatran versus warfarin after mechanical mitral valve replacement in the swine model
    John L Schomburg
    Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Invest Surg 25:150-5. 2012
    Mechanical heart valve replacement is an absolute indication for anticoagulation. We report our experience comparing dabigatran to warfarin as thromboembolic prophylaxis after mechanical mitral valve replacement in the swine model.
  69. ncbi Left atrial remodelling early after mitral valve repair for degenerative mitral regurgitation
    F Antonini-Canterin
    Cardiologia, ARC, Azienda Ospedaliera S Maria degli Angeli, Via Montereale, 24, 33170 Pordenone, Italy
    Heart 94:759-64. 2008
    Left atrial (LA) size is an important predictor of outcome after mitral valve replacement in patients with symptomatic chronic mitral regurgitation (MR)...
  70. ncbi A short-acting beta-blocker, landiolol, attenuates systolic anterior motion of the mitral valve after mitral valve annuloplasty
    Takeshi Omae
    Department of Anesthesiology and Critical Care Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    J Anesth 22:286-9. 2008
    Here, we describe three patients with severe hemodynamic instability after mitral valve annuloplasty (MVP) who were treated successfully using a new ultra-short-acting beta-blocker, landiolol hydrochloride...
  71. ncbi Left atrial radiofrequency ablation during mitral valve surgery for continuous atrial fibrillation: a randomized controlled trial
    George Doukas
    Department of Cardiac Surgery, Glenfield Hospital, University Hospitals of Leicester NHS Trust, England
    JAMA 294:2323-9. 2005
    ..radiofrequency ablation (RFA) is increasingly used for the treatment of chronic atrial fibrillation during mitral valve surgery, its efficacy to restore sinus rhythm and any resulting benefits have not been examined in the context ..
  72. ncbi Influence of chronic tethering of the mitral valve on mitral leaflet size and coaptation in functional mitral regurgitation
    Ken Saito
    Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
    JACC Cardiovasc Imaging 5:337-45. 2012
    ....
  73. ncbi Mitral valve surgery using the classical 'heartport' technique
    William H Ryan
    Cardiopulmonary Research Science and Technology Institute, Dallas, Texas, USA
    J Heart Valve Dis 14:709-14; discussion 714. 2005
    ..Herein, the authors compared their experience of the first 117 'Heartport' (HP) patients with a computer-matched group of sternotomy approach surgical patients (SP) to assess operative risk and 30-day outcome...
  74. ncbi Long-term outcome of modified maze procedure combined with mitral valve surgery: analysis of outcomes according to type of mitral valve surgery
    Joon Bum Kim
    Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
    J Thorac Cardiovasc Surg 139:111-7. 2010
    ..Efficacy of the maze procedure for atrial fibrillation associated with advanced mitral disease not amenable to repair has not been determined. This study investigated whether type of mitral surgery affects maze outcome...
  75. pmc Mitral annular hinge motion contribution to changes in mitral septal-lateral dimension and annular area
    Akinobu Itoh
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Thorac Cardiovasc Surg 138:1090-9. 2009
    ..Normal physiologic mechanisms of annular motion are incompletely understood, and more complete characterization is needed to provide rational basis for annuloplasty ring design and to enhance clinical outcomes...
  76. ncbi Factors influencing survival and postoperative quality of life after mitral valve reconstruction
    Lorenz Hansen
    Albertinen Krankenhaus, Hamburg, Germany
    Eur J Cardiothorac Surg 37:635-44. 2010
    b>Mitral valve reconstruction (MVR) is the preferred treatment for regurgitant lesions...
  77. ncbi Paravalvular leakage after mitral valve replacement: improved long-term survival with aggressive surgery?
    M Genoni
    Division of Cardiac Surgery, University Hospital, Zurich, Switzerland
    Eur J Cardiothorac Surg 17:14-9. 2000
    Following mitral valve replacement, surgical closure of paravalvular leaks is usually advised in severely symptomatic patients and in those requiring blood transfusions for persisting haemolysis...
  78. ncbi Efficacy, feasibility, and pitfalls of transseptal approach in beating-heart mitral valve surgery
    Tomas A Salerno
    Division of Cardiothoracic Surgery and Perfusion, University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida 33136, USA
    J Card Surg 24:495-8. 2009
    b>Mitral valve surgery can be performed through the trans-atrial or the trans-septal approach...
  79. ncbi Clinical implication of mitral annular plane systolic excursion for patients with cardiovascular disease
    Kai Hu
    Department of Internal Medicine I, Comprehensive Heart Failure Center, University of Wurzburg, Oberdürrbacher Str 6, 97080 Wurzburg, Germany
    Eur Heart J Cardiovasc Imaging 14:205-12. 2013
    ....
  80. ncbi A real-time 3-dimensional digital Doppler method for measurement of flow rate and volume through mitral valve in children: a validation study compared with magnetic resonance imaging
    Shuping Ge
    Division of Pediatric Cardiology, University of Iowa, USA
    J Am Soc Echocardiogr 18:1-7. 2005
    ..and assessed a real-time 3-dimensional (3D) digital Doppler method for measurement of flow volumes through the mitral valve in children. A total of 13 children (aged 10.46 +/- 2.5 years; 8 boys/5 girls) were enrolled...
  81. ncbi The Cox maze procedure in mitral valve disease: predictors of recurrent atrial fibrillation
    A Marc Gillinov
    Center for Atrial Fibrillation and the Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Thorac Cardiovasc Surg 130:1653-60. 2005
    The Cox maze procedure is the gold standard for ablation of atrial fibrillation in patients undergoing mitral valve surgery, and new approaches to atrial fibrillation ablation must be compared with it...
  82. ncbi Blood cyst of the mitral valve: a rare cause of stroke
    Ankur Lodha
    Maimonides Medical Center, Brooklyn, New York, USA
    Echocardiography 26:736-8. 2009
    ..We report a rare case of blood cyst attached to the mitral valve and a possible cause of an embolic stroke.
  83. ncbi Mitral valve surgery plus concomitant atrial fibrillation ablation is superior to mitral valve surgery alone with an intensive rhythm control strategy
    Ulrich O von Oppell
    University Hospital Wales, Cardiff, United Kingdom
    Eur J Cardiothorac Surg 35:641-50. 2009
    ..randomised study comparing patients with atrial fibrillation (AF) of more than 6 months duration after mitral valve surgery plus biatrial modified radiofrequency Maze procedure using Medtronic Cardioblate System (Cardioblate ..
  84. ncbi Echocardiographic predictors of left ventricular function and clinical outcomes after successful mitral valve repair: conventional two-dimensional versus speckle-tracking parameters
    Jong Min Song
    Division of Cardiology, Department of Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
    Ann Thorac Surg 91:1816-23. 2011
    ..conventional echocardiographic versus speckle tracking-derived parameters in predicting postoperative left ventricular (LV) dysfunction and clinical outcomes after successful mitral valve repair in patients with mitral regurgitation.
  85. ncbi Left atrial radiofrequency ablation during mitral valve surgery: a prospective randomized multicentre study (SAFIR)
    Philippe Chevalier
    Department of Cardiology Rythmology, Hospices Civils de Lyon, Hopital Cardiologique Louis Pradel, CHU Louis Pradel, avenue du doyen Lepine, Lyon Cedex 03, France
    Arch Cardiovasc Dis 102:769-75. 2009
    Randomized studies evaluating left atrial radiofrequency ablation (RFA) in patients with persistent atrial fibrillation undergoing mitral valve surgery are scarce and monocentric.
  86. ncbi The effect of regional ischemia on mitral valve annular saddle shape
    Joseph H Gorman
    Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 77:544-8. 2004
    The mitral valve annulus has a distinctive saddle shape. Recent finite element analysis indicates this shape may contribute to normal valve function by increasing leaflet curvature and reducing leaflet stress...
  87. ncbi Three-dimensional quantitation of mitral valve coaptation by a novel software system with transthoracic real-time three-dimensional echocardiography
    Miwako Tsukiji
    Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
    J Am Soc Echocardiogr 21:43-6. 2008
    We investigated the degree of mitral valve coaptation with a custom quantitation software system using transthoracic three-dimensional (3D) echocardiography...
  88. ncbi The transseptal approach to the mitral valve during multivalvular surgery
    Koray Aykut
    Department of Cardiovascular Surgery, Ozel Ege Hospital, Denizli, Turkey
    J Card Surg 26:472-4. 2011
    We investigated the short and mid-term outcome of the transseptal approach to the mitral valve during multivalvular surgery.
  89. ncbi Hemisternotomy approach for aortic and mitral valve surgery
    A M Gillinov
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Ohio 44195, USA
    J Card Surg 15:15-20. 2000
    ..we have concluded that the partial upper sternotomy is the incision of choice for minimally invasive aortic and mitral valve surgery...
  90. ncbi Use of an expanded polytetrafluoroethylene patch as an artificial leaflet in mitral valve plasty: an early experience
    Toshiaki Ito
    Department of Cardiovascular Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya, Japan
    Ann Thorac Surg 89:1620-4. 2010
    The purpose of this study was to examine the usefulness of polytetrafluoroethylene (PTFE) patches as artificial mitral leaflets in complex mitral valve plasty.
  91. ncbi Mitral valve finite element modeling: implications of tissues' nonlinear response and annular motion
    Marco Stevanella
    Department of Bioengineering, Politecnico di Milano, Via Golgi 39, 20133 Milano, Italy
    J Biomech Eng 131:121010. 2009
    ..Some of the computed results may be useful in the design of surgical devices and techniques. In particular, forces applied on the annulus by the surrounding tissues could be considered as an indication for annular prostheses design...
  92. ncbi Minimally invasive mitral valve repair using transthoracic aortic occlusion
    W R Chitwood
    Department of Surgery, East Carolina University School of Medicine, Greenville, North Carolina 27858, USA
    Ann Thorac Surg 63:1477-9. 1997
    This report describes a minimally invasive mitral valve repair done through a limited (6-cm) thoracic incision...
  93. ncbi Mechanisms of recurrent functional mitral regurgitation after mitral valve repair in nonischemic dilated cardiomyopathy: importance of distal anterior leaflet tethering
    Alex Pui Wai Lee
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Circulation 119:2606-14. 2009
    Recurrent functional mitral regurgitation (MR) has been reported after mitral valve repair with annuloplasty in patients with dilated cardiomyopathy, but the mechanism is not understood completely...
  94. ncbi Minitransseptal versus left atrial approach to the mitral valve: a comparison of outcomes
    Jeffrey J Nienaber
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 82:834-9; discussion 839. 2006
    Approaches to the mitral valve include left atriotomy (LA) through the interatrial groove and transseptal approach (TS) through the right atrium...
  95. ncbi Clinical significance of calcification of the fibrous skeleton of the heart and aortosclerosis in community dwelling elderly. The Cardiovascular Health Study (CHS)
    Eddy Barasch
    Department of Research and Education, St Francis Hospital, SUNY at Stony Brook, Roslyn, NY, USA
    Am Heart J 151:39-47. 2006
    ..No studies have examined the prevalence and the clinical relevance of all 3 forms of calcification in a single free-living elderly population...
  96. ncbi Minimally invasive port access versus conventional mitral valve surgery: prospective randomized study
    Selami Dogan
    Department of Thoracic and Cardiovascular Surgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Ann Thorac Surg 79:492-8. 2005
    We compared the port access mitral valve surgery with the conventional procedure through median sternotomy in a prospective randomized study.
  97. ncbi Retrograde arterial perfusion, not incision location, significantly increases the risk of stroke in reoperative mitral valve procedures
    Gregory A Crooke
    Department of Cardiothoracic Surgery, New York University Medical Center, New York, New York 10016, USA
    Ann Thorac Surg 89:723-9; discussion 729-30. 2010
    A recent report suggested that a thoracotomy approach for reoperative mitral valve (MV) procedures was associated with an equivalent mortality and an unacceptable risk of stroke...
  98. ncbi Transaortic chordae and pannus removal without redo mitral valve replacement in prosthetic mitral valve malfunction
    Byungjoon Park
    Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Eur J Cardiothorac Surg 39:1057-8. 2011
    Both anterior and posterior chordae of the mitral valve are occasionally spared during mitral valve surgery to preserve left ventricular function...
  99. ncbi Fatal thrombosis after mitral valve replacement for endocarditis: aprotinin and disseminated intravascular coagulation
    John G Augoustides
    Anesthesiology 104:213. 2006
  100. ncbi Mitral valve disease in Marfan syndrome and related disorders
    Daniel P Judge
    Division of Cardiology, Johns Hopkins University, Ross 1049 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Cardiovasc Transl Res 4:741-7. 2011
    ..Myxomatous thickening and elongation of the mitral valve (MV) leaflets commonly occur in this condition...
  101. pmc Spinal abscess and mitral valve endocarditis secondary to asymptomatic fusobacterium-induced dental abscess
    S I Goolamali
    Department of Rheumatology, East Surrey Hospital, Redhill, Surrey RH1 5RH, UK
    J R Soc Med 99:368-9. 2006

Research Grants63

  1. Shared Mechanisms of Valvular and Vascular Calcification
    JOEL DAVID MORRISETT; Fiscal Year: 2012
    ..Moreover, it has recently been shown that the primary aortic valve disease (calcific) and primary mitral valve disease (myxomatous) involve upregulation of chondrogenic genes, but progression to osteogenesis only occurs in ..
  2. Regulation of Periostin by TGFbeta and BMP in Heart Development
    Thomas Doetschman; Fiscal Year: 2010
    ..g. Marfan's syndrome, Ehlers-Danlos syndrome, floppy mitral valve syndrome and mitral valve prolapse)...
  3. Probabilistic Modeling of Stenotic Aortic Valve Intervention
    Wei Sun; Fiscal Year: 2013
    ..as different patient demographics, and could also be utilized to facilitate the development of other novel device designs or pre-operative patient screening techniques for different valve diseases, such as mitral valve regurgitation.
  4. University of Montreal Cardiac Surgery Clinical Investigation Group
    LOUIS PAUL PERRAULT; Fiscal Year: 2013
    ..and elderly patients, numerous ssues remain to be clarified concerning the best treatment options for ischemic mitral valve regurgitation and novel therapy for pulmonary hypertension...
  5. A percutaneous cardiac implant to treat mitral valve regurgitation
    Michael Lesh; Fiscal Year: 2013
    ..Our long- term goal is approval by the FDA for commercial sale within the US via the Premarket Approval process. ..
  6. Improving Mitral Compensation in Ischemic Regurgitation
    Robert A Levine; Fiscal Year: 2013
    ..Effective repair has been elusive for IMR, which is caused by left ventricular (LV) remodeling that tethers the mitral valve (MV) leaflets and restricts their closure - a mismatch between valve and LV size...
  7. Stabilization Device for Transseptal Access
    MARK CHRISTIAN SVENDSEN; Fiscal Year: 2013
    ..AF) ablation, left atrial appendage (LAA) closure, patent foramen ovale (PFO) closure, and treatment of mitral valve regurgitation (MR)...
  8. Cardioscopy New Platform for Less Invasive Surgery on the Beating Heart
    Tomislav Mihaljevic; Fiscal Year: 2013
    ..These include mitral valve repair and the resection of parts of the LV septal wall...
  9. Using gold nanorods to modify the extracellular matrix and mechanical properties
    Edie C Goldsmith; Fiscal Year: 2010
    ..When the balance of collagen turnover is altered, the mechanical properties of the mitral valve leaflets change...
  10. Delayed Enhancement MRI for Detection of Sub-Clinical Papillary Muscle Infarction
    Jonathan W Weinsaft; Fiscal Year: 2013
    ..mitral regurgitation, whereby myocyte necrosis produces papillary muscle dysfunction, impaired tethering of the mitral valve leaflets, and regurgitant flow...
  11. Polymer Therapy for Ischemic Mitral Regurgitation
    Judy W Hung; Fiscal Year: 2013
    ..We plan on studying the effectiveness of properties of this polymer and its effect on the heart muscle and mitral valve function so that it can be used in the most effective way in patients with ischemic mitral regurgitation...
  12. Left Ventricular Torsional Hysteresis: A Global Parameter for Diastolic Function
    Himanshu Gupta; Fiscal Year: 2013
    ..mitral regurgitation with progressive systolic dysfunction in a canine model of mitral regurgitation or in mitral valve repair in humans with isolated mitral regurgitation and preserved systolic function...
  13. INHIBITORY LEFT ATRIAL INFLUENCES ON THE BAROREFLEX
    David Ramsay; Fiscal Year: 1991
    ..without release of atrial natriuretic factor (ANF), and compared with inflation of a balloon placed at the mitral valve orifice which increases afferent discharge and ANF release...
  14. Mitral Regurgitation, Heart Failure and Coronary Disease: Benefits to MV Repair?
    Robert Michler; Fiscal Year: 2012
    ..Specific Aim #1 of Project 1 is to determine whether mitral valve repair (MVr) results in improved exercise capacity compared to optimal medical management (OMM) in patients ..
  15. Alteration in the mitral valve stress following repair surgeries
    Rouzbeh Amini; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Many patients in the United States undergo mitral valve (MV) repair each year. Long-term studies have shown less optimistic results for repair durability...
  16. Blood Outgrowth Endothelial Cell Seeding of Heart Valve Leaflets
    Robert J Levy; Fiscal Year: 2010
    ..We will then study ABV modified with lead CPB compounds and BOEC seeded with mitral valve flow simulations...
  17. Cardothoracic Surgery Network
    JOHN DANIEL PUSKAS; Fiscal Year: 2013
    ..of major adverse cardiac events (MACE) 30 days after isolated CABG will be lower than after combined CABG with mitral valve surgery, and that the incidence of MACE 2 years after isolated CABG will not be higher than after combined CABG ..
  18. Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine
    Irving L Kron; Fiscal Year: 2013
    ..Specific Aim 2: To demonstrate the proof of concept for a subvalvular approach for ischemic mitral valve regurgitation by repositioning the posterior papillary muscle of the mitral valve in a phase II randomized ..
  19. Libman-Sacks Endocarditis and NPSLE
    Carlos Roldan; Fiscal Year: 2009
    ..NPSLE;2) 14 (38%) had cerebral infarcts on MRI;3) 22 (59%) had valve vegetations detected by TEE, mostly on the mitral valve (82%);4) cerebral infarcts were more common in patients with than without NPSLE (48% vs. 10%, p = 0...
  20. MVPS: Health Concerns, Role function, Health Service Use
    KRISTINE SCORDO; Fiscal Year: 2002
    DESCRIPTION: (provided by applicant) Mitral valve prolapse (MVP) is the most common valvular heart disease with millions of people newly diagnosed each year...
  21. Assessment of Left Ventricle Function Using Color M-Mode Echocardiography
    Pavlos P Vlachos; Fiscal Year: 2012
    ..These alterations are manifested by a reduction of the initial Vp and reduction of the distance from the mitral valve to the point where the deceleration occurs...
  22. Fully Automated 4D Echocardiographic Mitral Valve Analysis for Surgical Repair
    ALISON MARIE POUCH; Fiscal Year: 2013
    ..2,3] Mitral valve repair with undersized ring annuloplasty has become the preferred surgical treatment for both functional and ..
  23. CIRCULATORY CONTROL IN CHRONIC HYPOTENSIVE STATES
    ROSE ROBERTSON; Fiscal Year: 1990
    ..SOH), which overlaps clinically with "vasoregulatory" or "neurocirculatory" asthenia and a portion of the mitral valve prolapse population, and dysautonomic orthostatic hypotension (DOH), including patients with idiopathic ..
  24. Development of an Implantable "Plug and Play" TransApical to Aorta VAD
    Stephen Topaz; Fiscal Year: 2007
    ..demonstrate the interaction of the pump with intraventricular structures such as the anterior leaflet of the mitral valve and sub valvular structures. This performance testing will direct any further prototype modifications...
  25. Mitral Valve Dynamic Analysis And Potential Clinical Applications
    Hyunggun Kim; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mitral valve (MV) repair is the preferred treatment in patients with MV insufficiency. The unsolved problem in MV repair surgery is predicting which repair is optimal for each patient...
  26. Engineering Analysis of Minimally Invasive Mitral Valve Repair
    THUY M PHAM; Fiscal Year: 2012
    ..plan, the candidate will conduct research to investigate the biomechanics involved in minimally invasive mitral valve repair, through a combined experimental and computational study, to better understand underlying valve repair ..
  27. A Novel Polymeric Percutaneous Heart Valve Prosthesis
    SCOTT C CORBETT; Fiscal Year: 2010
    ..femoral approach for aortic placement or antegrade transapical approach for placement in the aortic or mitral valve position...
  28. Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine
    Michael Argenziano; Fiscal Year: 2013
    ..that would be best completed as part of this proposed network: (1) to compare clinical outcomes following mitral valve surgery (MVS) with and without endocardial surgical ablation in patients with a history of continuous atrial ..
  29. The dynamic role of Wnt signaling in valve development
    FERNANDA BOSADA; Fiscal Year: 2013
    ..morphogen to direct stratification of the valve and establish the leaflet- chordae tendineae boundary in the mitral valve during late valvulogenesis...
  30. Remodeling potential of the mitral valve following surgical repair
    Ajit P Yoganathan; Fiscal Year: 2013
    ..applicant): After two decades of emphasis on valve replacement, cardiac surgeons have been gradually turning to mitral valve repair...
  31. Echocardiography to Predict Recurrent IMR After Surgical Mitral Valve Replacement
    Robert C Gorman; Fiscal Year: 2013
    ..Valve incompetence in IMR occurs due to a variable combination of leaflet tethering and annular dilation. Mitral valve (MV) repair with undersized annuloplasty rings has become the preferred treatment;however, while annuloplasty ..
  32. Hedgehog signaling during cardiovascular patterning in the mouse
    JOHN A KLINGENSMITH; Fiscal Year: 2010
    ..in A-V cushion development can result in severe congenital heart defects such as A-V canal or tricuspid and mitral valve atresias...
  33. ECHOCARDIOGRAPHIC STROKE PREDICTORS IN A TRI-ETHNIC COMM
    Marco Di Tullio; Fiscal Year: 2003
    ..of the risk associated with less frequent abnormalities (patent foramen ovale, mitral annular calcification, mitral valve prolapse). Finally, the prevalence of a patent foramen ovale in each race-ethnic group will be evaluated...
  34. Mitral Saddle Shape Preservation Improves Valvuloplasty
    Joseph H Gorman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): As experience has increased, surgeons have come to view mitral valve repair as the treatment of choice in patients with mitral regurgitation (MR) due to myxomatous leaflet degeneration and ischemic ..
  35. Percutaneous Mitral Valve Repair: A Validated Fluid-Structure Interaction Model
    Karyn S Kunzelman; Fiscal Year: 2013
    Mitral regurgitation is the most common heart valve problem encountered in clinical practice. Mitral valve repair is considered superior to mitral valve replacement, and there many surgical techniques utilized to address differing ..
  36. Quantitative Force Measurements to Optimize Valve Repair for Ischemic MR
    Ajit P Yoganathan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ischemic mitral regurgitation (IMR) occurs when a structurally normal mitral valve (MV) is rendered incompetent as a result of myocardial infarction induced left ventricular remodeling...
  37. Baylor Core Clinical Center for the Cardiothoracic Surgical Network
    Michael Mack; Fiscal Year: 2013
    ..cardiologists, staff and research coordinators meet bi-weekly to screen all patients (~25 per week) with aortic/mitral valve disease or AF for study eligibility...
  38. Ancillary Comparative Effectiveness of Atrial Fibrillation Ablation Surgery
    Eugene Blackstone; Fiscal Year: 2013
    ..No Surgical Ablation for Patients with Persistent or Longstanding Persistent Atrial Fibrillation Undergoing Mitral Valve Surgery" (NCT00903370), which is part of the NHLBI-sponsored Cardiothoracic Surgery Network (CTSN)...
  39. Computational Study of Fibrillins in CV Morphogenesis
    BRENDA RONGISH; Fiscal Year: 2004
    ..abnormalities, patients with these disorders manifest aortic root dilatation, aortic insufficiency, and mitral valve prolapse...
  40. COMPUTATIONAL METHODS IN CARDIAC FLUID DYNAMICS
    CHARLES PESKIN; Fiscal Year: 1990
    ..include valve pathology such as stenosis and regurgitation, specific syndromes involving the valves such as Mitral Valve Prolapse Syndrome and idiopathic Hypertrophic Subaortic Stenosis, and conditions in which wall motion abnormal ..
  41. MITRAL VALVE REGURGITATION INDUCES STRUCTURAL CHANGES
    Richard Cochran; Fiscal Year: 2000
    ..are to use a unique 3-D computer model to improve the timing and type of treatment offered to patients with mitral valve regurgitation, and to assess whether there is a role for earlier valve repair in selected etiologies...
  42. A Nanofibrous Bioactive Prosthetic Sewing Cuff
    Matthew Phaneuf; Fiscal Year: 2009
    ..with this number increasing due to an aging population and, to a lesser extent, a more aggressive approach to mitral valve insufficiency...
  43. Strategies for Transcatheter Mitral Valve Replacement
    Joseph H Gorman; Fiscal Year: 2013
    ..A transcatheter approach to mitral valve replacement (TMVR) would represent a major advance in treatment since approximately 2...
  44. MECHANISM OF VENTRICULAR OUTFLOW OBSTRUCTION IN IHSS
    Robert Levine; Fiscal Year: 1991
    ..This gradient represents obstruction from septal thickening and an abnormal systolic anterior motion of the mitral valve, or SAM, toward the septum...
  45. MYOCARDIAL DEFECTS INDUCED BY POTASSIUM DEPLETION
    CARLOS HARRISON; Fiscal Year: 1980
    ..Previous observations suggest that patients free of evidence of coronary disease with long-standing mitral valve insufficiency (volume overload) may fail to improve following replacement of the mitral valves because of ..
  46. ASSESSMENT OF DIASTOLIC FUNCTION IN HUMANS
    James Thomas; Fiscal Year: 1999
    ..by disease state, being reduced in low-flow states with limited mitral opening and abruptly increasing when the mitral valve is enlarged by percutaneous valvuloplasty; 4) the operating stiffness of the left ventricle can be quantified ..
  47. ATRIOVENTRICULAR INTERACTIONS RELATED TO CARDIAC SURGERY
    Peter Smith; Fiscal Year: 1992
    ..for cardiac surgery, patients with impaired ventricular function will require the preservation of atrial and mitral valve function for survival...
  48. 3D echocardiography to evaluate ischemic mitral regurgitation in humans.
    CLAYTON JOSEPH BRINSTER; Fiscal Year: 2009
    ..Results following mitral valve repair for IMR have been disappointing, and experienced centers report failure rates as high as 50% at 6 months ..
  49. PSYCHOBIOLOGY OF ANXIETY DISORDERS
    Jack Gorman; Fiscal Year: 1991
    ..markers of panic during laboratory and ambulatory monitoring, continuation of work on the relationship of mitral valve prolapse to panic, collaboration in family studies of anxiety disorder using biologic probes, beginning of work ..
  50. DEVELOP A HEMOCOMPATIBLE, EASY-TO-USE, COST-EFFECTIVE BLOOD PURIFIC
    Phillip Chan; Fiscal Year: 2013
    The purpose of this research is to evaluate the feasibility of transcatheter based mitral valve annuloplasty for correcting secondary mitral valve regurgitation...
  51. INFLUENCE OF FLOW DYNAMICS ON THROMBOGENESIS
    RICHARD SCHOEPHOERSTER; Fiscal Year: 1991
    ..be developed, which can be used to quantify the detailed flow dynamics in the vicinity of various geometries of mitral valve prostheses. The type of flow dynamics produced by a prosthetic mitral valve include those studied in Phase I...
  52. Endocardial dysfunction in humans with AF
    HUA LINDA CAI; Fiscal Year: 2006
    ..Stroke risk is increased by over 17 fold in patients with rheumatic mitral valve disease-related AF...
  53. Endovascular surgery system for atrial septal defect repair
    BRIAN FILL; Fiscal Year: 2006
    ..the expansion of endovascular procedures such as surgical manipulations of the left atrial appendage or failing mitral valve. An atrial septal defect (ASD) is a malformation in the heart which historically has been corrected with open- ..
  54. SBIR TT - Transcatheter Cerclage Mitral Valve Annulopasty for Secon
    MATT POLLMAN; Fiscal Year: 2013
    The purpose of this research is to evaluate the feasibility of transcatheter based mitral valve annuloplasty for correcting secondary mitral valve regurgitation...
  55. Innovative Tools & Techniques for Robotic Heart Surgery
    Gregory Buckner; Fiscal Year: 2006
    ..Based on East Carolinas University's experience in MIRA mitral valve repairs, patient bypass times are currently increased approximately 60% (2.6 hours with MIRA vs. 1...
  56. INTRALUMINAL ROBOT ASSISTED MITRAL VALVE REPAIR
    David Brock; Fiscal Year: 2000
    An intraluminal robot assisted mitral valve repair technique (IRAMVR) is proposed for use in minimally invasive mitral valve surgery (MI-MVS)...
  57. ANXIETY AND REGIONAL CEREBRAL BLOOD FLOW
    Roy Mathew; Fiscal Year: 1990
    ..It would also explain the central mechanisms of cerebral ischemia, commonly associated with acute anxiety. Lastly, it might provide new insights into the association between anxiety, mitral valve prolapse and stroke.
  58. ULTRASONIC EPICARDIAL ABLATION FOR TREATING ATRIAL FIB.
    Richard Bernardi; Fiscal Year: 2003
    ..population will be AF patients undergoing cardiac surgery such as coronary artery bypass grafts (CABG) and mitral valve replacement (MVR)...
  59. QUANTIFICATION OF HEART BETA ADRENERGIC RECEPTORS
    Raymond Muzic; Fiscal Year: 2002
    ..in coronary heart disease, congestive and ischemic heart failure, cardiomyopathy, sudden death, arrhythmia, and mitral valve disease. Drugs that interact with the beta-ARs, beta-blockers, are widely prescribed to treat heart disease...