aortic valve

Summary

Summary: The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.

Articles from Journal RESEARCH

Top Publications

  1. doi Transcatheter versus surgical aortic-valve replacement in high-risk patients
    Craig R Smith
    Columbia University Medical Center New York Presbyterian Hospital, New York, NY 10032, USA
    N Engl J Med 364:2187-98. 2011
  2. ncbi A classification system for the bicuspid aortic valve from 304 surgical specimens
    Hans H Sievers
    Klinik fur Herzchirurgie, Universitaetsklinikum Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    J Thorac Cardiovasc Surg 133:1226-33. 2007
  3. doi Transcatheter aortic valve implantation: early results of the FRANCE (FRench Aortic National CoreValve and Edwards) registry
    Helene Eltchaninoff
    Cardiology Department, Charles Nicolle Hospital, University of Rouen INSERM U644, 1 rue de Germont, Rouen Cedex, France
    Eur Heart J 32:191-7. 2011
  4. pmc Loss of Gata5 in mice leads to bicuspid aortic valve
    Brigitte Laforest
    Program in Molecular Biology, University of Montreal, Montreal, Quebec, Canada
    J Clin Invest 121:2876-87. 2011
  5. doi Transcatheter aortic valve implantation: first results from a multi-centre real-world registry
    Ralf Zahn
    Abteilung fur Kardiologie, Herzzentrum Ludwigshafen, Bremserstrasse 79, Ludwigshafen, Germany
    Eur Heart J 32:198-204. 2011
  6. ncbi Mutations in NOTCH1 cause aortic valve disease
    Vidu Garg
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Nature 437:270-4. 2005
  7. doi Bicuspid aortic valves with different spatial orientations of the leaflets are distinct etiological entities
    Borja Fernandez
    Department of Animal Biology, Faculty of Science, University of Malaga, Malaga, Spain
    J Am Coll Cardiol 54:2312-8. 2009
  8. pmc Standardized endpoint definitions for transcatheter aortic valve implantation clinical trials: a consensus report from the Valve Academic Research Consortium
    Martin B Leon
    Columbia University Medical Center, Center for Interventional Vascular Therapy, 173 Fort Washington Avenue, Heart Center, New York, NY 10032, USA
    Eur Heart J 32:205-17. 2011
  9. doi Bicuspid aortic valve leaflet morphology in relation to aortic root morphology: a study of 300 patients undergoing open-heart surgery
    Veronica Jackson
    Cardiothoracic Surgery Unit at the Department of Molecular Medicine and Surgery at Karolinska Institutet and Karolinska University Hospital
    Eur J Cardiothorac Surg 40:e118-24. 2011
  10. doi Transcatheter aortic valve implantation for the treatment of severe symptomatic aortic stenosis in patients at very high or prohibitive surgical risk: acute and late outcomes of the multicenter Canadian experience
    Josep Rodes-Cabau
    Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada
    J Am Coll Cardiol 55:1080-90. 2010

Detail Information

Articles from Journal RESEARCH1

Publications295 found, 100 shown here

  1. doi Transcatheter versus surgical aortic-valve replacement in high-risk patients
    Craig R Smith
    Columbia University Medical Center New York Presbyterian Hospital, New York, NY 10032, USA
    N Engl J Med 364:2187-98. 2011
    ..However, the two procedures have not been compared in a randomized trial involving high-risk patients who are still candidates for surgical replacement...
  2. ncbi A classification system for the bicuspid aortic valve from 304 surgical specimens
    Hans H Sievers
    Klinik fur Herzchirurgie, Universitaetsklinikum Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    J Thorac Cardiovasc Surg 133:1226-33. 2007
    ..This may also be valid for the bicuspid aortic valve, because the term "bicuspid aortic valve" stands for a common congenital aortic valve malformation with ..
  3. doi Transcatheter aortic valve implantation: early results of the FRANCE (FRench Aortic National CoreValve and Edwards) registry
    Helene Eltchaninoff
    Cardiology Department, Charles Nicolle Hospital, University of Rouen INSERM U644, 1 rue de Germont, Rouen Cedex, France
    Eur Heart J 32:191-7. 2011
    Transcatheter aortic valve implantation is a therapeutic alternative for high-surgical-risk patients with severe symptomatic aortic stenosis...
  4. pmc Loss of Gata5 in mice leads to bicuspid aortic valve
    Brigitte Laforest
    Program in Molecular Biology, University of Montreal, Montreal, Quebec, Canada
    J Clin Invest 121:2876-87. 2011
    Bicuspid aortic valve (BAV), the leading congenital heart disease, occurs in 1%-2% of the population. Genetic studies suggest that BAV is an autosomal-dominant disease with reduced penetrance...
  5. doi Transcatheter aortic valve implantation: first results from a multi-centre real-world registry
    Ralf Zahn
    Abteilung fur Kardiologie, Herzzentrum Ludwigshafen, Bremserstrasse 79, Ludwigshafen, Germany
    Eur Heart J 32:198-204. 2011
    ..Transcatheter aortic valve interventions [balloon valvuloplasty and transcatheter aortic valve implantation (TAVI)] are evolving as ..
  6. ncbi Mutations in NOTCH1 cause aortic valve disease
    Vidu Garg
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Nature 437:270-4. 2005
    Calcification of the aortic valve is the third leading cause of heart disease in adults. The incidence increases with age, and it is often associated with a bicuspid aortic valve present in 1-2% of the population...
  7. doi Bicuspid aortic valves with different spatial orientations of the leaflets are distinct etiological entities
    Borja Fernandez
    Department of Animal Biology, Faculty of Science, University of Malaga, Malaga, Spain
    J Am Coll Cardiol 54:2312-8. 2009
    ..The aim of this study was to decide whether bicuspid aortic valves (BAVs) with fused right and noncoronary leaflets (R-N) and BAVs with fused right and left leaflets (R-L) have different etiologies or are the product of a single diathesis...
  8. pmc Standardized endpoint definitions for transcatheter aortic valve implantation clinical trials: a consensus report from the Valve Academic Research Consortium
    Martin B Leon
    Columbia University Medical Center, Center for Interventional Vascular Therapy, 173 Fort Washington Avenue, Heart Center, New York, NY 10032, USA
    Eur Heart J 32:205-17. 2011
    To propose standardized consensus definitions for important clinical endpoints in transcatheter aortic valve implantation (TAVI), investigations in an effort to improve the quality of clinical research and to enable meaningful comparisons ..
  9. doi Bicuspid aortic valve leaflet morphology in relation to aortic root morphology: a study of 300 patients undergoing open-heart surgery
    Veronica Jackson
    Cardiothoracic Surgery Unit at the Department of Molecular Medicine and Surgery at Karolinska Institutet and Karolinska University Hospital
    Eur J Cardiothorac Surg 40:e118-24. 2011
    There is an ongoing discussion regarding the mechanism of aortic dilatation in bicuspid aortic valve (BAV) disease, that is, is this a hemodynamic effect or related to an inborn weakness of the aortic wall? This study evaluated the ..
  10. doi Transcatheter aortic valve implantation for the treatment of severe symptomatic aortic stenosis in patients at very high or prohibitive surgical risk: acute and late outcomes of the multicenter Canadian experience
    Josep Rodes-Cabau
    Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada
    J Am Coll Cardiol 55:1080-90. 2010
    The aim of this study was: 1) to evaluate the acute and late outcomes of a transcatheter aortic valve implantation (TAVI) program including both the transfemoral (TF) and transapical (TA) approaches; and 2) to determine the results of ..
  11. doi The early and midterm function of decellularized aortic valve allografts
    Francisco D A da Costa
    Department of Cardiac Surgery, Santa Casa de Curitiba, Pontificia Universidade Catolica do Parana, Curitiba, Parana, Brazil
    Ann Thorac Surg 90:1854-60. 2010
    This study evaluates the early and midterm results of decellularized aortic valve allografts (DAVA) as an aortic valve replacement.
  12. doi Incidence of aortic complications in patients with bicuspid aortic valves
    Hector I Michelena
    Division of Cardiovascular Disease, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    JAMA 306:1104-12. 2011
    Bicuspid aortic valve (BAV), the most common congenital heart defect, has been thought to cause frequent and severe aortic complications; however, long-term, population-based data are lacking.
  13. doi Thirty-day results of the SAPIEN aortic Bioprosthesis European Outcome (SOURCE) Registry: A European registry of transcatheter aortic valve implantation using the Edwards SAPIEN valve
    Martyn Thomas
    St Thomas Hospital, London, UK
    Circulation 122:62-9. 2010
    Transcatheter aortic valve implantation was developed to mitigate the mortality and morbidity associated with high-risk traditional aortic valve replacement...
  14. pmc Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Room 5420, Charlestown, MA 02129, USA
    Circulation 119:1785-94. 2009
    ..Here, we used genetically modified mice and molecular imaging to test the hypothesis in vivo that cathepsin S (catS), a potent elastolytic proteinase, accelerates calcification in atherosclerotic mice with CRD induced by 5/6 nephrectomy...
  15. ncbi Bicuspid aortic valve is heritable
    Linda Cripe
    Department of Pediatrics, Division of Cardiology, Cincinnati Children s Hospital, Ohio 45229, USA
    J Am Coll Cardiol 44:138-43. 2004
    Previous studies have established familial clustering of bicuspid aortic valve (BAV), presumably indicating genetic inheritance...
  16. ncbi Percutaneous aortic valve implantation retrograde from the femoral artery
    John G Webb
    Division of Cardiology, St Paul s Hospital, Vancouver, British Columbia, Canada
    Circulation 113:842-50. 2006
    Percutaneous aortic valve implantation by an antegrade transvenous approach has been described but is problematic. Retrograde prosthetic aortic valve implantation via the femoral artery has potential advantages...
  17. ncbi Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulate aortic valve calcification
    Jens J Kaden
    First Department of Medicine Cardiology, Angiology, and Pneumology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theordor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Mol Cell Cardiol 36:57-66. 2004
    ..Receptor Activator of Nuclear factor kappaB Ligand" (RANKL) and osteoprotegerin (OPG) are members of a cytokine system involved in bone turnover and vascular calcification. Their role in calcific AS is not known...
  18. pmc Human aortic valve calcification is associated with an osteoblast phenotype
    Nalini M Rajamannan
    Division of Cardiology, Northwestern University Feinberg School of Medicine, Northwestern University, 201 East Huron St, Galter Suite 10 240, Chicago, Ill 60611, USA
    Circulation 107:2181-4. 2003
    ..We hypothesized that the mechanism for aortic valve calcification is similar to skeletal bone formation and that this process is mediated by an osteoblast-like ..
  19. ncbi Abnormal aortic valve development in mice lacking endothelial nitric oxide synthase
    T C Lee
    Division of Cardiology, Terrence Donnelly Heart Center, St Michael s Hospital, University of Toronto, Ontario, Canada
    Circulation 101:2345-8. 2000
    ..Therefore, we investigated the role of endothelium-derived NO during cardiovascular development using mice deficient in eNOS...
  20. ncbi A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis
    S Joanna Cowell
    Department of Cardiology, Royal Infirmary, Edinburgh, United Kingdom
    N Engl J Med 352:2389-97. 2005
    ..We hypothesized that intensive lipid-lowering therapy would halt the progression of calcific aortic stenosis or induce its regression...
  21. pmc Aortic root dilatation in young men with normally functioning bicuspid aortic valves
    S Nistri
    Sanitary Service, Regione Carabinieri Veneto, Via Brigata Padova 19, 35100 Padova, Italy
    Heart 82:19-22. 1999
    To evaluate the dimensions of the aortic root in a selected population of young males with isolated normally functioning bicuspid aortic valve.
  22. doi Upregulation of the 5-lipoxygenase pathway in human aortic valves correlates with severity of stenosis and leads to leukotriene-induced effects on valvular myofibroblasts
    Edit Nagy
    Center for Molecular Medicine, CMM L8 03, Karolinska University Hospital, Stockholm, Sweden
    Circulation 123:1316-25. 2011
    The development of aortic valve stenosis is not only associated with calcification and extracellular matrix remodeling, but also with inflammation...
  23. doi Two-year outcomes after transcatheter or surgical aortic-valve replacement
    Susheel K Kodali
    Columbia University Medical Center and New York Presbyterian Hospital, New York, NY 10032, USA
    N Engl J Med 366:1686-95. 2012
    ..However, longer-term follow-up is necessary to determine whether TAVR has prolonged benefits...
  24. doi Transcatheter aortic-valve replacement for inoperable severe aortic stenosis
    Raj R Makkar
    Cedars Sinai Heart Institute, Los Angeles, USA
    N Engl J Med 366:1696-704. 2012
    ..Transcatheter aortic-valve replacement (TAVR) is the recommended therapy for patients with severe aortic stenosis who are not suitable candidates for surgery. The outcomes beyond 1 year in such patients are not known...
  25. doi Impact of myocardial fibrosis in patients with symptomatic severe aortic stenosis
    Frank Weidemann
    University Clinic of Internal Medicine I Center for Cardiovascular Disease, University of Wurzburg, 97080 Wurzburg, Germany
    Circulation 120:577-84. 2009
    ..follow-up study, the effect of myocardial fibrosis on myocardial performance in symptomatic severe aortic stenosis was investigated, and the impact of fibrosis on clinical outcome after aortic valve replacement (AVR) was estimated.
  26. ncbi Long-term survival after the Bentall procedure in 206 patients with bicuspid aortic valve
    Christian D Etz
    Department of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann Thorac Surg 84:1186-93; discussion 1193-4. 2007
    The recognition that patients with a bicuspid aortic valve (BAV) are at risk for aorta-related death (rupture or dissection) has favored composite aortic root replacement in BAV patients who undergo aortic valve replacement for valve ..
  27. doi The bicuspid aortic valve: an integrated phenotypic classification of leaflet morphology and aortic root shape
    B M Schaefer
    Department of Medicine, Division of Cardiology, Seattle, WA, USA
    Heart 94:1634-8. 2008
    To establish a classification of bicuspid aortic valve (BAV) that includes both leaflet morphology and aortic shape.
  28. doi Bicuspid aortic valve disease
    Samuel C Siu
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    J Am Coll Cardiol 55:2789-800. 2010
    Bicuspid aortic valve (BAV) disease is the most common congenital cardiac defect. While the BAV can be found in isolation, it is often associated with other congenital cardiac lesions...
  29. pmc Quantification of hemodynamic wall shear stress in patients with bicuspid aortic valve using phase-contrast MRI
    Alex J Barker
    Department of Mechanical Engineering, University of Colorado, Boulder, CO 80309, USA
    Ann Biomed Eng 38:788-800. 2010
    Bicuspid aortic valve (BAV) is often concomitant with aortic dilatation, aneurysm, and dissection...
  30. ncbi Usefulness of bicuspid aortic valve phenotype to predict elastic properties of the ascending aorta
    Benjamin M Schaefer
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA
    Am J Cardiol 99:686-90. 2007
    Bicuspid aortic valve (BAV) affects about 0.5% to 2% of the population and predisposes patients to aortic dilation and dissection. We hypothesized that aortic size and elastic properties are related to BAV phenotype...
  31. ncbi Percutaneous implantation of the CoreValve self-expanding valve prosthesis in high-risk patients with aortic valve disease: the Siegburg first-in-man study
    Eberhard Grube
    Department of Cardiology Angiology, HELIOS Heart Center Siegburg, Ringstrasse 49, 53721 Siegburg, Germany
    Circulation 114:1616-24. 2006
    The morbidity and mortality of surgical aortic valve replacement are increased in elderly patients with multiple high-risk comorbid conditions...
  32. ncbi Failure to prevent progressive dilation of ascending aorta by aortic valve replacement in patients with bicuspid aortic valve: comparison with tricuspid aortic valve
    Hisayo Yasuda
    Department of Cardiology, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Circulation 108:II291-4. 2003
    Patients with bicuspid aortic valve (BAV) have been frequently complicated with ascending aortic dilation possibly because of hemodynamic burdens by aortic stenosis (AS) or regurgitation (AR) or congenital fragility of the aortic wall.
  33. ncbi Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms
    Stephen H McKellar
    Department of Surgery Division of Cardiovascular Surgery, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    J Thorac Cardiovasc Surg 134:290-6. 2007
    Bicuspid aortic valve is a common condition and is associated with a significantly increased risk of developing thoracic aortic aneurysms and acute aortic dissection...
  34. doi Cell-matrix interactions in the pathobiology of calcific aortic valve disease: critical roles for matricellular, matricrine, and matrix mechanics cues
    Jan Hung Chen
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada
    Circ Res 108:1510-24. 2011
    The hallmarks of calcific aortic valve disease (CAVD) are the significant changes that occur in the organization, composition, and mechanical properties of the extracellular matrix (ECM), ultimately resulting in stiffened stenotic ..
  35. ncbi Transforming growth factor-beta1 mechanisms in aortic valve calcification: increased alkaline phosphatase and related events
    Jocelyn N Clark-Greuel
    Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Ann Thorac Surg 83:946-53. 2007
    b>Aortic valve stenosis is the most frequent indication for valve replacement surgery, and is commonly associated with pathologic calcification...
  36. pmc Natural history of asymptomatic patients with normally functioning or minimally dysfunctional bicuspid aortic valve in the community
    Hector I Michelena
    Divisions of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Circulation 117:2776-84. 2008
    Bicuspid aortic valve is frequent and is reported to cause numerous complications, but the clinical outcome of patients diagnosed with normal or mildly dysfunctional valve is undefined.
  37. ncbi Clinical and pathophysiological implications of a bicuspid aortic valve
    Paul W M Fedak
    Division of Cardiac Surgery, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada
    Circulation 106:900-4. 2002
  38. ncbi Early experience with percutaneous transcatheter implantation of heart valve prosthesis for the treatment of end-stage inoperable patients with calcific aortic stenosis
    Alain Cribier
    Department of Cardiology, Charles Nicolle Hospital, University of Rouen, Rouen, France
    J Am Coll Cardiol 43:698-703. 2004
    ..This study was done to assess the results of percutaneous heart valve (PHV) implantation in non-surgical patients with end-stage calcific aortic stenosis...
  39. doi Noncollagenous bone matrix proteins as a part of calcific aortic valve disease regulation
    Virva Pohjolainen
    Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland
    Hum Pathol 39:1695-701. 2008
    Clinically, calcific aortic valve disease is a progressive continuum from obstructive fibro(sclero)tic valve thickening to aortic stenosis...
  40. ncbi Cardiovascular morbidity and mortality in community-dwelling elderly individuals with calcification of the fibrous skeleton of the base of the heart and aortosclerosis (The Cardiovascular Health Study)
    Eddy Barasch
    Department of Research and Education, St Francis Hospital, Roslyn, New York, USA
    Am J Cardiol 97:1281-6. 2006
    In the elderly, mitral annular calcification (MAC) and aortic valve sclerosis (AVS) are associated with increased cardiovascular morbidity and mortality. Aortic annular calcification (AAC) commonly occurs with MAC...
  41. doi Surgical management of aortic root disease in Marfan syndrome: a systematic review and meta-analysis
    Umberto Benedetto
    Department of Cardiac Surgery, University of Rome Sapienza, Policlinico S Andrea, Rome, Italy
    Heart 97:955-8. 2011
    ..Surgical treatment of aortic root aneurysm in Marfan syndrome (MFS) patients...
  42. ncbi Impact of valve prosthesis-patient mismatch on left ventricular mass regression following aortic valve replacement
    Giordano Tasca
    Department of Cardiac Surgery, Poliambulanza Hospital, Brescia, Italy
    Ann Thorac Surg 79:505-10. 2005
    Valve prosthesis-patient mismatch is a frequent problem in patients undergoing aortic valve replacement and its main hemodynamic consequence is to generate high transvalvular gradients through normally functioning prosthetic valves...
  43. doi Transcatheter valve implantation for patients with aortic stenosis: a position statement from the European Association of Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of Percu
    Alec Vahanian
    Hopital Bichat, Paris, France
    Eur Heart J 29:1463-70. 2008
    To critically review the available transcatheter aortic valve implantation techniques and their results, as well as propose recommendations for their use and development.
  44. doi Long-term risk of aortic events following aortic valve replacement in patients with bicuspid aortic valves
    Stephen H McKellar
    Department of Surgery, Division of Cardiovascular Surgery, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Am J Cardiol 106:1626-33. 2010
    Bicuspid aortic valve (BAV) is associated with ascending aortopathy predisposing to aneurysmal dilatation and dissection, even after successful aortic valve replacement (AVR)...
  45. ncbi Aortic valve sclerosis and aortic atherosclerosis: different manifestations of the same disease? Insights from a population-based study
    Y Agmon
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 38:827-34. 2001
    The aim of this study was to examine the association between atherosclerosis risk factors, aortic atherosclerosis and aortic valve abnormalities in the general population.
  46. ncbi The bicuspid aortic valve
    Alan C Braverman
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Probl Cardiol 30:470-522. 2005
    The bicuspid aortic valve affects 1 to 2% of the population and may be complicated by aortic stenosis or aortic insufficiency and infective endocarditis...
  47. doi Percutaneous transarterial aortic valve implantation: what do we know?
    John Webb
    St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada
    Eur Heart J 32:140-7. 2011
    Transcatheter aortic valve implantation (TAVI) is assuming a major role in the routine management of patients with aortic stenosis...
  48. doi Aortic annulus evaluation in transcatheter aortic valve implantation
    Andrea Hutter
    Clinic for Cardiovascular Surgery, German Heart Centre Munich, Munich, Germany
    Catheter Cardiovasc Interv 76:1009-19. 2010
    We compared the annulus diameters measured by transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), and dual-source computed tomography (DSCT) before transcatheter aortic valve implantation (TAVI).
  49. pmc Comparison between cardiovascular magnetic resonance and transthoracic Doppler echocardiography for the estimation of effective orifice area in aortic stenosis
    Julio Garcia
    Quebec Heart and Lung Institute, Laval University, Quebec, Canada
    J Cardiovasc Magn Reson 13:25. 2011
    ..Cardiovascular magnetic resonance (CMR) has emerged as an alternative method for non-invasive estimation of valve EOA. The objective of this study was to assess the concordance between TTE and CMR for the estimation of valve EOA...
  50. doi Permanent pacemaker insertion after CoreValve transcatheter aortic valve implantation: incidence and contributing factors (the UK CoreValve Collaborative)
    M Z Khawaja
    UK CoreValve Collaborative, Sussex Cardiac Centre, Brighton and Sussex University Hospital Trust, Eastern Road, Brighton, East Sussex, BN2 5BE, UK
    Circulation 123:951-60. 2011
    Permanent pacemaker (PPM) requirement is a recognized complication of transcatheter aortic valve implantation...
  51. doi Assessment of valvular calcification and inflammation by positron emission tomography in patients with aortic stenosis
    Marc Richard Dweck
    Centre for Cardiovascular Science, University of Edinburgh, Little France Crescent, Edinburgh, United Kingdom
    Circulation 125:76-86. 2012
    ..The pathophysiology of aortic stenosis is incompletely understood, and the relative contributions of valvular calcification and inflammation to disease progression are unknown...
  52. doi Transcatheter aortic valve implantation for high-risk patients with severe aortic stenosis: A systematic review
    Tristan D Yan
    Department of Cardiothoracic Surgery, The University of Sydney, Royal Prince Alfred Hospital, Sydney 2050, Australia
    J Thorac Cardiovasc Surg 139:1519-28. 2010
    The present systematic review objectively assessed the safety and clinical effectiveness of transcatheter aortic valve implantation for patients at high surgical risk with severe aortic stenosis.
  53. doi Relationship between the logistic EuroSCORE and the Society of Thoracic Surgeons Predicted Risk of Mortality score in patients implanted with the CoreValve ReValving system--a Bern-Rotterdam Study
    Nicolo Piazza
    Interventional Cardiology Department, Erasmus Medical Center, Thoraxcenter, s Gravendijkwal 230, Rotterdam, The Netherlands
    Am Heart J 159:323-9. 2010
    ..of Mortality (STS) score, are commonly used to identify high-risk or "inoperable" patients for transcatheter aortic valve implantation (TAVI)...
  54. doi Endothelial function, carotid-femoral stiffness, and plasma matrix metalloproteinase-2 in men with bicuspid aortic valve and dilated aorta
    Nikolaos Tzemos
    Division of Cardiology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Am Coll Cardiol 55:660-8. 2010
    This study sought to examine the relationship between proximal aortic dilation and systemic vascular function in men with bicuspid aortic valve (BAV).
  55. doi Biomechanical implications of the congenital bicuspid aortic valve: a finite element study of aortic root function from in vivo data
    Carlo A Conti
    Department of Bioengineering, Politecnico di Milano, Milan, Italy
    J Thorac Cardiovasc Surg 140:890-6, 896.e1-2. 2010
    ..By using imaging-derived data, finite element models were developed to quantify aortic valve and root biomechanical alterations associated with bicuspid geometry.
  56. doi Outcomes in adults with bicuspid aortic valves
    Nikolaos Tzemos
    Peter Munk Cardiac Centre and Toronto Congenital Cardiac Centre for Adults, University Health Network, University of Toronto, Toronto, Ontario, Canada
    JAMA 300:1317-25. 2008
    Bicuspid aortic valve is the most common congenital cardiac anomaly in the adult population. Cardiac outcomes in a contemporary population of adults with bicuspid aortic valve have not been systematically determined.
  57. doi Valve configuration determines long-term results after repair of the bicuspid aortic valve
    Diana Aicher
    Department of Thoracic and Cardiovascular Surgery, University Hospitals Homburg, Homburg, Germany
    Circulation 123:178-85. 2011
    Reconstruction of the regurgitant bicuspid aortic valve has been performed for >10 years, but there is limited information on long-term results. We analyzed our results to determine the predictors of suboptimal outcome.
  58. doi Refining molecular pathways leading to calcific aortic valve stenosis by studying gene expression profile of normal and calcified stenotic human aortic valves
    Yohan Bosse
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, Pavillon Margeritte d Youville, Y4190, 2725, Chemin Sainte Foy, Quebec City, Quebec, Canada
    Circ Cardiovasc Genet 2:489-98. 2009
    Calcific aortic valve stenosis (AS) is a major societal and economic burden that is rising after the current shift toward an older population...
  59. ncbi Should the ascending aorta be replaced more frequently in patients with bicuspid aortic valve disease?
    Michael A Borger
    Division of Cardiovascular Surgery, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    J Thorac Cardiovasc Surg 128:677-83. 2004
    The optimal diameter at which replacement of the ascending aorta should be performed in patients with bicuspid aortic valve disease is not known.
  60. ncbi Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation
    Paul W M Fedak
    Division of Cardiac Surgery, University of Toronto and Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    J Thorac Cardiovasc Surg 126:797-806. 2003
    Patients with bicuspid aortic valve malformations are at an increased risk of aortic dilatation, aneurysm formation, and dissection...
  61. doi Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial
    Neil J Howell
    Department of Cardiothoracic Surgery, University Hospital Birmingham, Edgbaston, Birmingham, UK
    Circulation 123:170-7. 2011
    Patients undergoing aortic valve replacement for critical aortic stenosis often have significant left ventricular hypertrophy...
  62. pmc Synergistic effects of cyclic tension and transforming growth factor-beta1 on the aortic valve myofibroblast
    W David Merryman
    Engineered Tissue Mechanics Laboratory, Department of Bioengineering and the McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Cardiovasc Pathol 16:268-76. 2007
    Phenotypically, aortic valve interstitial cells are dynamic myofibroblasts, appearing contractile and activated in times of development, disease, and remodeling...
  63. ncbi Differential immediate-early gene responses to elevated pressure in porcine aortic valve interstitial cells
    James N Warnock
    Agricultural and Biological Engineering, Mississippi State University, Box 9632, Mississippi State, MS 39762 9632, USA
    J Heart Valve Dis 15:34-41; discussion 42. 2006
    Cardiovascular risk factors are believed to play a role in the pathogenesis of aortic valve disease...
  64. pmc Elevated cyclic stretch induces aortic valve calcification in a bone morphogenic protein-dependent manner
    Kartik Balachandran
    The Wallace H Coulter School of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Dr, Suite 1121, Atlanta, GA 30332 0535, USA
    Am J Pathol 177:49-57. 2010
    Calcified aortic valve (AV) cusps have increased expression of bone morphogenic proteins (BMPs) and transforming growth factor-beta1 (TGF-beta1)...
  65. doi Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease
    Kartik Balachandran
    The Wallace H Coulter School of Biomedical Engineering, Georgia Inst of Technology, 313 Ferst Dr, Ste 1121, Atlanta, GA 30332 0535, USA
    Am J Physiol Heart Circ Physiol 296:H756-64. 2009
    Matrix metalloproteinases (MMPs) and cathepsins are proteolytic enzymes that are upregulated in diseased aortic valve cusps...
  66. ncbi Multivariable prediction of in-hospital mortality associated with aortic and mitral valve surgery in Northern New England
    Edward R Nowicki
    Dartmouth Medical School, Hanover, New Hampshire 03756, USA
    Ann Thorac Surg 77:1966-77. 2004
    ..Development of reliable prediction rules requires large data sets with appropriate risk factors that are available before surgery...
  67. ncbi Patient-prosthesis mismatch does not affect survival following aortic valve replacement
    Neil J Howell
    Department of Cardiothoracic Surgery, University Hospital NHS Foundation Trust, Birmingham, UK
    Eur J Cardiothorac Surg 30:10-4. 2006
    ..has been reported to increase perioperative mortality and reduce postoperative survival in patients undergoing aortic valve replacement (AVR)...
  68. doi Comparison of aortic root dimensions and geometries before and after transcatheter aortic valve implantation by 2- and 3-dimensional transesophageal echocardiography and multislice computed tomography
    Arnold C T Ng
    Department of Cardiology, The Department of Cardiothoracic Surgery, and the Department of Radiology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Circ Cardiovasc Imaging 3:94-102. 2010
    ..We assessed agreements between 2D and 3D TEE measurements with multislice computed tomography (MSCT) and changes in annular/LVOT areas and geometries after transcatheter aortic valve implantations (TAVI).
  69. ncbi Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis
    Bo Jian
    Cardiology Research Laboratory, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Ann Thorac Surg 75:457-65; discussion 465-6. 2003
    b>Aortic valve stenosis characteristically progresses due to cuspal calcification, often necessitating valve replacement surgery...
  70. pmc Aortic valve endothelial cells undergo transforming growth factor-beta-mediated and non-transforming growth factor-beta-mediated transdifferentiation in vitro
    G Paranya
    Department of Surgery, Children's Hospital, Boston, Massachusetts 02115, USA
    Am J Pathol 159:1335-43. 2001
    ..of transdifferentiation were identified in clonally derived endothelial cell populations isolated from ovine aortic valve leaflets...
  71. ncbi Congenital quadricuspid aortic valve: report of nine surgical cases
    Goichi Yotsumoto
    Second Department of Surgery, Kagoshima University, Faculty of Medicine, Sakuragaoka, Kagoshima, Japan
    Ann Thorac Cardiovasc Surg 9:134-7. 2003
    We report the clinicopathologic characteristics of the congenital quadricuspid aortic valve necessitating surgery. Among 616 patients for whom we performed an aortic valve operation over the past 20 years, nine patients (1...
  72. ncbi Tissue engineering of cardiac valve prostheses I: development and histological characterization of an acellular porcine scaffold
    Catherine Booth
    Division of Microbiology, University of Leeds, UK
    J Heart Valve Dis 11:457-62. 2002
    ..The study aim was to optimize a protocol to produce a porcine acellular matrix scaffold for use in developing a tissue-engineered heart valve...
  73. pmc Notch1 represses osteogenic pathways in aortic valve cells
    Vishal Nigam
    Gladstone Institute of Cardiovascular Disease and Departments of Pediatrics, University of California, San Francisco, CA 94158, USA
    J Mol Cell Cardiol 47:828-34. 2009
    ..We reported two families in which heterozygous mutations in NOTCH1 caused bicuspid aortic valve and severe aortic valve calcification...
  74. doi Evaluation of anatomic valve opening and leaflet morphology in aortic valve bioprosthesis by using multidetector CT: comparison with transthoracic echocardiography
    Fabien Chenot
    Divisions of Cardiology and Radiology Cliniques Universitaires St Luc, Universite Catholique de Louvain, Avenue Hippocrate 10 2881, B 1200 Brussels, Belgium
    Radiology 255:377-85. 2010
    To prospectively determine whether cardiac-gated multidetector computed tomography (CT) allows visualization of aortic valve leaflets after bioprosthetic aortic valve replacement (AVR), to provide an accurate method for measuring the ..
  75. doi Late outcomes for aortic valve replacement with the Carpentier-Edwards pericardial bioprosthesis: up to 17-year follow-up in 1,000 patients
    R Scott McClure
    Division of Cardiac Surgery, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ann Thorac Surg 89:1410-6. 2010
    This study reviews a single institution experience with the Carpentier-Edwards pericardial aortic valve bioprosthesis, concentrating on late outcomes.
  76. ncbi Novel missense mutations (p.T596M and p.P1797H) in NOTCH1 in patients with bicuspid aortic valve
    Salah A Mohamed
    Department of Cardiac Surgery, University of Schleswig Holstein, Campus Luebeck, Germany
    Biochem Biophys Res Commun 345:1460-5. 2006
    The bicuspid aortic valve (BAV) is the most common congenital cardiac malformation, occurring in 1-2% of the population...
  77. ncbi Dilation of the pulmonary autograft after the Ross procedure
    T E David
    Divisions of Cardiovascular Surgery and Cardiology of Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 119:210-20. 2000
    ..Dilation of pulmonary autograft after the Ross procedure is being recognized with increasing frequency. This study was undertaken to examine the extent of this problem and factors that may be associated with it...
  78. doi Endothelium-dependent regulation of the mechanical properties of aortic valve cusps
    Ismail El-Hamamsy
    Tissue Engineering Department, Harefield Heart Science Centre, National Heart and Lung Institute, Imperial College London, Harefield, United Kingdom
    J Am Coll Cardiol 53:1448-55. 2009
    The aim of this study was to evaluate the role of valve endothelium in regulating the mechanical properties of aortic valve cusps.
  79. doi Bicuspid aortic valve: four-dimensional MR evaluation of ascending aortic systolic flow patterns
    Michael D Hope
    Department of Radiology, University of California San Francisco, 505 Parnassus Ave, Box 0628, San Francisco, CA 94143 0628, USA
    Radiology 255:53-61. 2010
    ..phase-contrast magnetic resonance (MR) imaging, also called four-dimensional flow MR imaging, to evaluate systolic blood flow patterns in the ascending aorta that may predispose patients with a bicuspid aortic valve (BAV) to aneurysm.
  80. ncbi Morphometric analysis of aortic media in patients with bicuspid and tricuspid aortic valve
    Matthias Bauer
    Deutsches Herzzentrum Berlin, Germany
    Ann Thorac Surg 74:58-62. 2002
    ..The aim of this study was to analyze whether or not there is any histologic difference in the aortic media of patients with a bicuspid aortic valve or a tricuspid aortic valve.
  81. doi Altered shear stress stimulates upregulation of endothelial VCAM-1 and ICAM-1 in a BMP-4- and TGF-beta1-dependent pathway
    Philippe Sucosky
    Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556 5637, USA
    Arterioscler Thromb Vasc Biol 29:254-60. 2009
    Hemodynamics has been associated with aortic valve (AV) inflammation, but the underlying mechanisms are not well understood...
  82. ncbi Evidence in favor of linkage to human chromosomal regions 18q, 5q and 13q for bicuspid aortic valve and associated cardiovascular malformations
    Lisa J Martin
    Center for Epidemiology and Biostatistics, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Hum Genet 121:275-84. 2007
    ..The aim of this study was to identify regions of the genome that harbor genes influencing inheritance of bicuspid aortic valve (BAV) and/or associated cardiovascular malformation (CVM)...
  83. pmc Dilatation of the ascending aorta in paediatric patients with bicuspid aortic valve: frequency, rate of progression and risk factors
    A E Warren
    Division of Pediatric Cardiology, Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
    Heart 92:1496-500. 2006
    To describe the incidence and rate of dilatation of the ascending aorta in children with bicuspid aortic valve (BAV) and to determine factors that predict rapid aortic dilatation.
  84. ncbi Observed and relative survival after aortic valve replacement
    P Kvidal
    Department of Cardiology, University Hospital, Uppsala, Sweden
    J Am Coll Cardiol 35:747-56. 2000
    We sought to evaluate the effects of a number of factors that can potentially determine the optimal time for aortic valve replacement (AVR) and the observed and relative survival after the operation.
  85. ncbi Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice
    Katsuhiro Hanada
    Department of Cell Biology and Genetics, Erasmus MC, Rotterdam, The Netherlands
    Circ Res 100:738-46. 2007
    ..They display thickened aortic valvular leaflets that are associated with aortic valve stenosis and insufficiency...
  86. pmc Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves
    Craig A Simmons
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia PA 19104, USA
    Circ Res 96:792-9. 2005
    Calcific aortic valve sclerosis involves inflammatory processes and occurs preferentially on the aortic side of endothelialized valve leaflets...
  87. ncbi Predictors of ascending aortic dilatation with bicuspid aortic valve: a wide spectrum of disease expression
    Alessandro Della Corte
    Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, V Monaldi Hospital, Via L Bianchi, 80131 Naples, Italy
    Eur J Cardiothorac Surg 31:397-404; discussion 404-5. 2007
    This study aimed to describe the features and identify the predictors of ascending aorta dilatation in patients with congenital bicuspid aortic valve (BAV).
  88. ncbi Paradoxical low-flow, low-gradient severe aortic stenosis despite preserved ejection fraction is associated with higher afterload and reduced survival
    Zeineb Hachicha
    Laval Hospital Research Center Quebec Heart Institute, Department of Medicine, Laval University, Quebec, Canada
    Circulation 115:2856-64. 2007
    ..and current clinical observations suggest that some patients with severe aortic stenosis on the basis of aortic valve area may paradoxically have a relatively low gradient despite the presence of a preserved left ventricular (LV) ..
  89. doi Role of multislice computed tomography in transcatheter aortic valve replacement
    David A Wood
    Division of Cardiology, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Cardiol 103:1295-301. 2009
    Transcatheter aortic valve replacement (TAVR) required precise knowledge of the anatomic dimensions and physical characteristics of the aortic valve, annulus, and aortic root...
  90. ncbi Comparison of different decellularization procedures of porcine heart valves
    M T Kasimir
    Department of Cardiothoracic Surgery and Ludwig Boltzmann Institute for Cardiosurgical Research, University of Vienna, Vienna, Austria
    Int J Artif Organs 26:421-7. 2003
    ..Tissue engineering of heart valves should avoid the disadvantages of conventional prostheses. In this study we tested different decellularization procedures for their potential of cell removal and their ability to preserve the matrix...
  91. pmc To operate or not on elderly patients with aortic stenosis: the decision and its consequences
    B J Bouma
    Department of Cardiology, Academic Medical Centre, University of Amsterdam, PO Box 2700, 1100 DE Amsterdam, The Netherlands
    Heart 82:143-8. 1999
    ..To evaluate the application of guidelines in the decision making process leading to medical or surgical treatment for aortic stenosis in elderly patients...
  92. ncbi Study on decellularized porcine aortic valve/poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) hybrid heart valve in sheep model
    Song Wu
    Department of Cardiovascular Surgery, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
    Artif Organs 31:689-97. 2007
    ..The hybrid valve may provide superior valve replacement with current techniques...
  93. doi Cost-effectiveness of transcatheter aortic valve replacement compared with standard care among inoperable patients with severe aortic stenosis: results from the placement of aortic transcatheter valves (PARTNER) trial (Cohort B)
    Matthew R Reynolds
    Saint Luke s Mid America Heart Institute, University of Missouri Kansas City School of Medicine, Kansas City, MO 64111, USA
    Circulation 125:1102-9. 2012
    In patients with severe aortic stenosis who cannot have surgery, transcatheter aortic valve replacement (TAVR) has been shown to improve survival and quality of life compared with standard therapy, but the costs and cost-effectiveness of ..
  94. doi Comparison of two-dimensional and three-dimensional imaging techniques for measurement of aortic annulus diameters before transcatheter aortic valve implantation
    Ertunc Altiok
    Department of Cardiology, University Hospital RWTH Aachen, Aachen, Germany
    Heart 97:1578-84. 2011
    ..3D) imaging techniques are used for procedure planning and selection of prosthesis size before transcatheter aortic valve implantation...
  95. doi Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2
    Xiaoping Yang
    Division of Cardiothoracic Surgery, Department of Surgery, University of Colorado Denver, Denver, CO, USA
    J Am Coll Cardiol 53:491-500. 2009
    Our aim was to determine whether aortic valve interstitial cells (AVICs) and pulmonary valve interstitial cells (PVICs) differ in expression of Toll-like receptor (TLR)2 and TLR4, response to TLR agonists, and osteogenic phenotypic changes...
  96. doi Transforming growth factor-beta receptor type II mutation in a patient with bicuspid aortic valve disease and intraoperative aortic dissection
    Evaldas Girdauskas
    Department of Cardiac Surgery, Heart Center, Zentralklinik Bad Berka, Bad Berka, Germany
    Ann Thorac Surg 91:e70-1. 2011
    We report on a patient with familial bicuspid aortic valve disease operated on for proximal aortic aneurysm. The surgery was complicated by intraoperative aortic dissection...
  97. doi Absence of TGFBR1 and TGFBR2 mutations in patients with bicuspid aortic valve and aortic dilation
    Cammon B Arrington
    Department of Pediatrics, Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Am J Cardiol 102:629-31. 2008
    ..Because bicuspid aortic valve (BAV) is a congenital heart defect in patients with Loeys-Dietz syndrome, this study was conducted to ..
  98. pmc Combining dynamic stretch and tunable stiffness to probe cell mechanobiology in vitro
    Angela M Throm Quinlan
    Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts, United States of America
    PLoS ONE 6:e23272. 2011
    ..As a demonstration of the system, porcine aortic valve interstitial cells (VIC) and human mesenchymal stem cells (hMSC) were plated on soft and stiff substrates ..
  99. ncbi Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies
    Rosario V Freeman
    Division of Cardiology, Department of Medicine, University of Washington School of Medicine, Seattle, Wash 98195 6422, USA
    Circulation 111:3316-26. 2005
  100. doi Progress and current status of percutaneous aortic valve replacement: results of three device generations of the CoreValve Revalving system
    Eberhard Grube
    Departments of Cardiology, Cardiac Surgery, and Anaesthesiology, HELIOS Heart Center Siegburg, Ringstrasse 49, Siegburg, Germany
    Circ Cardiovasc Interv 1:167-75. 2008
    Percutaneous aortic valve replacement is a new emerging technology for interventional treatment of severe aortic valve stenosis in surgical high-risk patients...
  101. doi Transcatheter aortic valve implantation: role of multi-detector row computed tomography to evaluate prosthesis positioning and deployment in relation to valve function
    Victoria Delgado
    Department of Cardiology and Cardiothoracic Surgery, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, The Netherlands
    Eur Heart J 31:1114-23. 2010
    Aortic regurgitation after transcatheter aortic valve implantation (TAVI) is one of the most frequent complications. However, the underlying mechanisms of this complication remain unclear...

Research Grants68

  1. Targeting Cell Death to Prevent Ventricular Remodeling and Heart Failure
    Abhinav Diwan; Fiscal Year: 2011
    ..Nearly one third of the Veterans have ischemic heart disease and another third have hypertension and/or aortic valve stenosis, which cause heart failure...
  2. Novel Biomarkers in Aortic Aneurysms and Acute Aortic Dissection
    JENNIFER E contact VAN EYK; Fiscal Year: 2010
    ..in the ascending part of the thoracic aorta since it may lead to global myocardial ischemia by compromising the aortic valve and blood flow through the coronary arteries...
  3. Shared Mechanisms of Valvular and Vascular Calcification
    JOEL DAVID MORRISETT; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Calcific aortic valve disease (CAVD) is a degenerative disease for which the only treatment is surgical valve replacement...
  4. Control of Cardiogenesis by microRNA Editing
    Kazuko Nishikura; Fiscal Year: 2010
    ..ADAR2 expression is detected in the aortic sac at E10.5 and selected regions of embryonic heart including aortic valve at E14.5...
  5. Intravascular Cardiac Assist System for Decompression and Recovery
    CAITLYN J BOSECKER; Fiscal Year: 2010
    ..it successfully and consistently ejected 30 ml of blood during systole after the native ventricle opened the aortic valve and completed this ejection before the valve closed...
  6. Regulation of Periostin by TGFbeta and BMP in Heart Development
    Thomas Doetschman; Fiscal Year: 2010
    ..In humans POSTN protein is reduced in pediatric patients with bicuspid aortic valve. In adult valvular diseases mutations are found in TGF2 receptor genes (syndromic valve disease) and in the ..
  7. Tissue Engineered Aortic Heart Valves: Scaffolds and Stem Cells
    DAN TEODOR SIMIONESCU; Fiscal Year: 2013
    ..we propose to develop partially stabilized collagen scaffolds that structurally and functionally mimic the aortic valve fibrosa, ventricularis and spongiosa layers, to assemble them into tri-layered constructs shaped in the form of ..
  8. Tissue Engineering Strategies: Effects on Valvular Interstitial Cell Metabolism
    KATHRYN JANE GRANDE-ALLEN; Fiscal Year: 2012
    ..cells (VICs), especially as they relate to the tissue engineering of valves and the development of calcific aortic valve disease. Nonetheless, there has been scant investigation into the metabolism of valve cells...
  9. BMP2 Gene Regulation in Calcific Aortic Valve Disease
    Melissa B Rogers; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Congenital valve defects promote Calcific Aortic Valve Disease (CAVD). Bone morphogenetic protein 2 (BMP2) is a key signal in valve development...
  10. Endocrine Regulation of Calcific Aortic Valve Sclerosis: PTH/PTHRP Receptor Signa
    Dwight A Towler; Fiscal Year: 2013
    ..Therapeutic strategies focused solely on statin-based intervention have been ineffective in treating calcific aortic valve disease (CAVD). Type I diabetes (T2DM) and metabolic syndrome are major contributors to CAVD risk...
  11. Role of Inhibitory SMADs in Calcific Aortic Valve Disease
    Yin Tintut; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Role of Inhibitory SMADs in Calcific Aortic Valve Disease Calcific aortic valve disease (CAVD) is associated epidemiologically with hyperlipidemia, the biological effects of which appear to occur ..
  12. ROS Mechanisms in BAV Aortopathy
    THOMAS GILLETTE GLEASON; Fiscal Year: 2013
    ..ROS) accumulation in aortic smooth muscle cells (SMCs) mediates the aortopathy in patients with bicuspid aortic valve (BAV)...
  13. Mechanisms of Circadian Rhythmicity in CLOCK-Deficient Mice
    DAVID RAYMOND WEAVER; Fiscal Year: 2013
    ..occurs with aging, following trauma, and in genetic and idiopathic forms), to age-related aortic stenosis, and aortic valve calcification (which is a prominent complication limiting surgical repair of the heart and cardiac valves)...
  14. AGE/RAGE Interaction in Patients with Pressure Overload-Induced Heart Failure
    Michael R Zile; Fiscal Year: 2013
    ..provided by applicant): In response to the chronic pressure-overload caused by arterial hypertension or aortic valve stenosis, the myocardium undergoes hypertrophic remodeling that results in the development of left ventricular ..
  15. Exome Sequencing in Familial Cardiovascular Malformations
    KIM LEWIS MCBRIDE; Fiscal Year: 2012
    ..variation leading to a subgroup of CVMs, the left ventricular outflow tract (LVOT) malformations that includes aortic valve stenosis, coarctation of the aorta, and hypoplastic left heart syndrome...
  16. Role of Lrp5/Beta-Catenin in Aortic Valve Calcification
    Nalini M Rajamannan; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Aortic Valve Stenosis is a common consequence of the traditional risk factors for vascular atherosclerosis including: hypertension, hypercholesterolemia, smoking, increased BMI, aging and diabetes...
  17. Biomimetic micro-structured hydrogel scaffolds for tissue engineered heart valves
    Jennifer L West; Fiscal Year: 2013
    ..methodologies to generate advanced 3D hydrogels that mimic the complex microstructure and material behavior of aortic valve tissues...
  18. Basic Mechanisms of Human Calcific Aortic Valve Disease
    Gordon S Huggins; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Progressive calcific aortic valve disease (CAVD) is characterized by calcium deposition in the valve cusps as well as frank bone formation...
  19. Role of SIRT6 in calcific aortic valve disease
    Jordan D Miller; Fiscal Year: 2013
    ..Hemodynamically significant aortic valve stenosis affects 3% of the population over age 65...
  20. Shear stress, endothelial miRNAs, and AV calcification
    Ajit P Yoganathan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Calcific aortic valve (AV) disease is a major cause of cardiac-related deaths worldwide and is a strong risk factor for additional cardiovascular events...
  21. 2012 Notch Signaling in Development, Regeneration &Disease Gordon Conference
    Raphael Kopan; Fiscal Year: 2012
    ..alterations in Notch activity underlie several developmental syndromes (Alagille, Spondylocostal Dysostosis, aortic valve disease), adult onset diseases (CADASIL, various heart and valve malformations, muscular dystrophy, multiple ..
  22. Midcareer Mentoring Award for Patient Oriented Research in Geriatric Cardiology
    Mathew S Maurer; Fiscal Year: 2013
    ..using use of noninvasive pressure volume analysis and actigraphy in older adults undergoing percutaneous aortic valve replacement...
  23. A Novel Magnetic Resonance Imaging Marker of Myocardial Fibrosis
    Michael Jerosch-Herold; Fiscal Year: 2013
    ..in patients diagnosed with aortic stenosis with no previous history of coronary disease, who will undergo aortic valve replacement...
  24. Phase 2/3 of Covered Cheatham Platinum Stent for Aortic Wall Injury
    RICHARD ELLIOT RINGEL; Fiscal Year: 2013
    ..CoA can occur in isolation, in association with bicuspid aortic valve, or with major cardiac malformations...
  25. Probabilistic Modeling of Stenotic Aortic Valve Intervention
    Wei Sun; Fiscal Year: 2013
    ..Recently, minimally invasive transcatheter aortic valve (TAV) implantation has been investigated as an endovascular alternative to surgical valve replacement...
  26. Efficiencies for Outcome Ascertainment throughout the Total Product Life Cycle
    J Matthew Brennan; Fiscal Year: 2013
    ..mechanisms of HOI ascertainment to the conduct of both 1) the longitudinal surveillance of transcatheter aortic valve replacement (TAVR) prostheses using available unique device identifiers (UDI), and 2) a pragmatic registry-..
  27. Stroke &cognition in surgical aortic stenosis
    MICHAEL ANDREW ACKER; Fiscal Year: 2011
    ..The number of patients with this diagnosis and requiring aortic valve replacement(AVR) is growing rapidly with the aging of our population...
  28. Pro-inflammatory S100 protein as disease modifier in calcific aortic valve diseas
    MARION A HOFMANN-BOWMAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Calcific aortic valve disease is a growing health problem in our aging population...
  29. Imaging protease activation in calcific aortic valve disease
    Mehran M Sadeghi; Fiscal Year: 2013
    ..Aortic stenosis is the most common cause of valvular heart disease and calcific aortic valve disease (CAVD) is the most common cause of aortic stenosis...
  30. Functional Cardiovascular 4D MRI in Congenital Heart Disease
    Cynthia K Rigsby; Fiscal Year: 2013
    ..Bicuspid aortic valve (BAV), one of the most common forms of CHD, and single ventricle physiology (SVP), one of the most severe, are ..
  31. Genetic Etiology of Bicuspid Aortic Valve Disease
    Simon C Body; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bicuspid aortic valve (BAV) is the most frequent congenital cardiac malformation, occurring in 0.5-1.2% of the US population...
  32. Twist1 regulation of valve progenitors
    Katherine E Yutzey; Fiscal Year: 2013
    ..by applicant): Heart valve replacement is the second most common cardiac surgery in the United States, and aortic valve sclerosis, an indicator of calcification, occurs in >25% of aged individuals...
  33. Development of transapical MVAD for heart failure therapy
    Daniel Tamez; Fiscal Year: 2013
    ..The tMVAD is designed for intraventricular implantation with an outflow cannula that crosses the aortic valve. The device can be inserted via a minimally-invasive approach (subcostal incision or mini-thoracotomy) to ..
  34. Osteopontin: a Novel Biomarker for Calcific Aortic Valve Diseases
    Giovanni Ferrari; Fiscal Year: 2010
    ..Project Title: Osteopontin: a Novel Biomarker for Calcific Aortic Valve Diseases The calcification of the Aortic Valve represents a multifactorial process with varied underlying ..
  35. Surgeon Human Capital Depreciation Impacts on Resource Use and Patient Outcomes
    Jason Hockenberry; Fiscal Year: 2011
    ..used to treat coronary artery disease, CABG and PCI, as well as AAA repair surgery, carotid endarterectomy and aortic valve repair. There are two secondary aims...
  36. Cardioscopy New Platform for Less Invasive Surgery on the Beating Heart
    Tomislav Mihaljevic; Fiscal Year: 2013
    ..Cardioscope will be placed near the LV apex via a small thoracotomy or small subxiphoid incision or across the aortic valve via the carotid or femoral artery percutaneous approach...
  37. The Role of COX2 in the Progression of Calcific Aortic Valve Disease
    ELAINE EMILY WIRRIG; Fiscal Year: 2013
    ..The goal of the research proposed in this project is to identify the molecular mechanisms underlying aortic valve disease (AoVD) and potential therapeutic targets for the development of early medical treatment to halt AoVD ..
  38. Molecular and Cellular Mechanisms of Calcific Aortic Stenosis
    Bin Zhou; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Calcific aortic valve stenosis (CAVS) is the most common disease needed surgical valve replacement...
  39. Role of inflammatory response in aortic valve lesions
    Xianzhong Meng; Fiscal Year: 2013
    Summary Surgical valve replacement is the only available therapy for calcific aortic valve stenosis...
  40. TGF-beta1 activity in the aortic valve
    WILLIAM D MERRYMAN; Fiscal Year: 2013
    ..with the molecular mechanisms of TGF-(31 activity and cardiovascular pathophysiology to appropriately examine aortic valve (AV) sclerosis. The Candidate will be mentored by Dr. Joanne E...
  41. Role of Animal Models in Transcatheter Valve Intervention
    Wei Sun; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Minimally invasive transcatheter aortic valve (TAV) intervention holds promise for a large number of high- risk patients (advanced age and/or with co-morbidities) who might otherwise have limited or ..
  42. Bicuspid Valve Aortopathy: Feasibility of a Comparative Effectiveness Study
    CRAIG STANFORD BROBERG; Fiscal Year: 2013
    ..As many as 3 million Americans have or will have an enlarged thoracic aorta in the setting of a bicuspid aortic valve, even when valve function is normal...
  43. Serotonergic Receptor Targeted Therapy for Degenerative Aortic Valve Disease
    WILLIAM D MERRYMAN; Fiscal Year: 2013
    ..Studies have shown that degenerative aortic valve disease affects over 25% of people over 65 years of age, leading to calcific aortic valve disease (CAVD) in 4-8 ..
  44. Patient-Specific Modeling for Analysis of Aortic Aneurysms
    CAITLIN MARIE MARTIN; Fiscal Year: 2013
    ..to develop patient-specific finite element models for the analysis of ascending aortic aneurysm in bicuspid aortic valve (BAV) patients...
  45. Internet-Based Distributed Quantitative 4D Analysis of Aortic MR/MDCT Images
    Xiangmin Zhang; Fiscal Year: 2013
    ..quantitative 4D analysis of the entire aorta from MR/MDCT images for the entire aortic length between the aortic valve and the diaphragm...
  46. Shear Stress, BMP and Aortic Valve Inflammation
    Hanjoong Jo; Fiscal Year: 2010
    Inflammation and calcification are common features of the aortic valve (AV) diseases, which typically require surgical replacement of the valves...
  47. Wnt signaling in heart valve development and disease
    Katherine E Yutzey; Fiscal Year: 2013
    ..by applicant): Heart valve replacement is the second most common cardiac surgery in the United States and aortic valve sclerosis occurs in >25% of aged individuals...
  48. The Role of Notch Signaling in Arrhythmogenesis
    STACEY LYNN RENTSCHLER; Fiscal Year: 2013
    ..including the pathogenesis of many malignancies, as well as cardiac developmental defects such as bicuspid aortic valve and tetralogy of Fallot. However, a role for Notch in arrhythmic phenotypes has not previously been described...
  49. Therapeutic Strategy to slow progression of calcific aortic valve stenosis
    Hartzell V Schaff; Fiscal Year: 2013
    Hemodynamically significant calcific aortic valve stenosis (CAVS) affects 3% of the population over age 65, and patients with even moderate aortic valve stenosis (peak velocity of 3-4 m/sec) have a 5 year event-free survival of less than ..
  50. Tissue-engineered pulmonic valve grown from human cells for pediatric patients
    Robert T Tranquillo; Fiscal Year: 2013
    ..S. annually if this TEHV can subsequently be improved to withstand forces associated with the aortic valve position...
  51. Role of Osteoclastogenesis in Calcific Aortic Valve Disease
    Cecilia M Giachelli; Fiscal Year: 2013
    ..by applicant): Inflammation, fibrosis and ectopic calcification are common pathologies observed in calcific aortic valve disease (CAVD)...
  52. Genetic and Developmental Basis of Pediatric Aortic Valve Disease Pathogenesis
    ROBERT BRUCE HINTON; Fiscal Year: 2010
    ..a 'bedside to bench to bedside" approach to investigate the genetic causes and pathogenesis of pediatric aortic valve disease...
  53. Surgical Planning Tool for Aortic Valve Reconstruction
    Pedro J del Nido; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aortic valve disease is the third most common congenital left heart lesion, affecting 8% of all children born with heart defects...
  54. Effects of hydroxyapatite mineralization and valve cell phenotype
    JONATHAN TALBOT BUTCHER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Proper function of the aortic valve is critically important for efficient cardiac performance...
  55. A Novel Polymeric Percutaneous Heart Valve Prosthesis
    SCOTT C CORBETT; Fiscal Year: 2010
    ..polymeric trileaflet heart valve to a valve prosthesis that can be delivered percutaneously as a transcatheter aortic valve replacement...
  56. Aortic valve microcalcification
    Elena Aikawa; Fiscal Year: 2013
    ..cell (VIC)-derived matrix vesicles, precursors of microcalcification, offering the novel mechanism of calcific aortic valve disease (CAVD)...
  57. Cell Signaling Mechanisms of Calcific Aortic Valve Disease
    Katherine E Yutzey; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Calcific Aortic Valve Disease (CAVD) occurs in >2% of the population over 65 years of age and often leads to valvular stenosis that necessitates valve replacement...
  58. Freeze-Dried, Viable Allogeneic Heart Valves
    Kelvin Brockbank; Fiscal Year: 2006
    ..In this proposal, sheep aortic valve leaflet fibroblasts and aortic conduit smooth muscle cells will be used for optimization of freeze-drying, ..
  59. Fluid-structure simulation for prosthetic heart valves
    KRISHNAN CHANDRAN; Fiscal Year: 2009
    Degeneration of heart valves with congenital malformations, such as bicuspid aortic valve (BAV) and associated pathology of the aortic apparatus (including the root, sinus, and the valve leaflets), is a common clinical problem resulting ..
  60. SUBENDOCARDIAL O2 SUPPLY AND DEMAND IN AORTIC STENOSIS
    Peter Scholz; Fiscal Year: 1992
    ..All studies will be conducted on anesthetized open chest dogs 6 months after creation of aortic valve stenosis as puppies...
  61. Development of a TAVI Device with a Reduced Crossing Profile
    Todd N McAllister; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Transcatheter aortic valve implantation (TAVI) is a minimally invasive approach to valve replacement that has had a rapid and profound clinical impact...
  62. ADHESINS OF COAGULASE NEGATIVE STAPHYLOCOCCI
    Gerald Pier; Fiscal Year: 1999
    ..of PS/A-positive and -negative strains to spread from a contaminated intracardiac foreign body to adjacent aortic valve tissue; and finally, determining whether vaccination with PS/A, or passive infusion of an antibody to PS/A, ..
  63. Structural Analysis and Comparative Study of Surgical and Transcatheter Valve Dev
    Wei Sun; Fiscal Year: 2013
    ..Since the transcathete aortic valve (TAV) is made of similar biomaterials and acts as an alternative to a surgical bioprosthetic valve in the same ..
  64. THE GENETIC ETIOLOGY OF HYPOPLASTIC LEFT HEART SYNDROME
    Peter Bowers; Fiscal Year: 2004
    ..which includes first trimester spontaneous abortion, HLHS, aortic and mitral stenosis, coarctation and bicuspid aortic valve. With 2 percent of the general population having a bicuspid aortic valve, these lesions are extremely common...
  65. TRANSLUMINAL ANGIOPLASTY-CONVENITAL HEART DISEASE
    James Anderson; Fiscal Year: 1990
    ..and right ventricles will be used to evaluate the relationship between acute altered mechanical loading via aortic valve occlusion...
  66. ELASTIN DAMAGE: MECHANISM OF BIOPROSTHETIC VALUE FAILURE
    Ivan Vesely; Fiscal Year: 2002
    ..addressed mechanical degeneration, and have focused on understanding the structure/function relationship of aortic valve cusp tissues...
  67. Micromechanics of the Aortic Valve:Durability Testing
    Ivan Vesely; Fiscal Year: 2002
    b>Aortic valve disease is treated by replacing the diseased valve with either a mechanical or an animal tissue-based artificial heart valve. Unfortunately, neither device can provide good quality of life...
  68. A Composite Tissue-engineered Aortic Valve Prosthesis
    Ivan Vesely; Fiscal Year: 2006
    b>Aortic valve disease is treated by replacing the diseased valve with either a mechanical or an animal tissue-based artificial heart valve. Unfortunately, neither device can provide good quality of life...