Genomes and Genes
Summary: The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications295 found, 100 shown here
- Transcatheter versus surgical aortic-valve replacement in high-risk patientsCraig R Smith
Columbia University Medical Center New York Presbyterian Hospital, New York, NY 10032, USA
N Engl J Med 364:2187-98. 2011..However, the two procedures have not been compared in a randomized trial involving high-risk patients who are still candidates for surgical replacement...
- A classification system for the bicuspid aortic valve from 304 surgical specimensHans H Sievers
Klinik fur Herzchirurgie, Universitaetsklinikum Schleswig Holstein, Campus Luebeck, Luebeck, Germany
J Thorac Cardiovasc Surg 133:1226-33. 2007..This may also be valid for the bicuspid aortic valve, because the term "bicuspid aortic valve" stands for a common congenital aortic valve malformation with ..
- Transcatheter aortic valve implantation: early results of the FRANCE (FRench Aortic National CoreValve and Edwards) registryHelene Eltchaninoff
Cardiology Department, Charles Nicolle Hospital, University of Rouen INSERM U644, 1 rue de Germont, Rouen Cedex, France
Eur Heart J 32:191-7. 2011Transcatheter aortic valve implantation is a therapeutic alternative for high-surgical-risk patients with severe symptomatic aortic stenosis...
- Loss of Gata5 in mice leads to bicuspid aortic valveBrigitte Laforest
Program in Molecular Biology, University of Montreal, Montreal, Quebec, Canada
J Clin Invest 121:2876-87. 2011Bicuspid aortic valve (BAV), the leading congenital heart disease, occurs in 1%-2% of the population. Genetic studies suggest that BAV is an autosomal-dominant disease with reduced penetrance...
- Transcatheter aortic valve implantation: first results from a multi-centre real-world registryRalf Zahn
Abteilung fur Kardiologie, Herzzentrum Ludwigshafen, Bremserstrasse 79, Ludwigshafen, Germany
Eur Heart J 32:198-204. 2011..Transcatheter aortic valve interventions [balloon valvuloplasty and transcatheter aortic valve implantation (TAVI)] are evolving as ..
- Mutations in NOTCH1 cause aortic valve diseaseVidu Garg
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
Nature 437:270-4. 2005Calcification of the aortic valve is the third leading cause of heart disease in adults. The incidence increases with age, and it is often associated with a bicuspid aortic valve present in 1-2% of the population...
- Bicuspid aortic valves with different spatial orientations of the leaflets are distinct etiological entitiesBorja Fernandez
Department of Animal Biology, Faculty of Science, University of Malaga, Malaga, Spain
J Am Coll Cardiol 54:2312-8. 2009..The aim of this study was to decide whether bicuspid aortic valves (BAVs) with fused right and noncoronary leaflets (R-N) and BAVs with fused right and left leaflets (R-L) have different etiologies or are the product of a single diathesis...
- Standardized endpoint definitions for transcatheter aortic valve implantation clinical trials: a consensus report from the Valve Academic Research ConsortiumMartin B Leon
Columbia University Medical Center, Center for Interventional Vascular Therapy, 173 Fort Washington Avenue, Heart Center, New York, NY 10032, USA
Eur Heart J 32:205-17. 2011To propose standardized consensus definitions for important clinical endpoints in transcatheter aortic valve implantation (TAVI), investigations in an effort to improve the quality of clinical research and to enable meaningful comparisons ..
- Bicuspid aortic valve leaflet morphology in relation to aortic root morphology: a study of 300 patients undergoing open-heart surgeryVeronica Jackson
Cardiothoracic Surgery Unit at the Department of Molecular Medicine and Surgery at Karolinska Institutet and Karolinska University Hospital
Eur J Cardiothorac Surg 40:e118-24. 2011There is an ongoing discussion regarding the mechanism of aortic dilatation in bicuspid aortic valve (BAV) disease, that is, is this a hemodynamic effect or related to an inborn weakness of the aortic wall? This study evaluated the ..
- Transcatheter aortic valve implantation for the treatment of severe symptomatic aortic stenosis in patients at very high or prohibitive surgical risk: acute and late outcomes of the multicenter Canadian experienceJosep Rodes-Cabau
Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada
J Am Coll Cardiol 55:1080-90. 2010The aim of this study was: 1) to evaluate the acute and late outcomes of a transcatheter aortic valve implantation (TAVI) program including both the transfemoral (TF) and transapical (TA) approaches; and 2) to determine the results of ..
- The early and midterm function of decellularized aortic valve allograftsFrancisco D A da Costa
Department of Cardiac Surgery, Santa Casa de Curitiba, Pontificia Universidade Catolica do Parana, Curitiba, Parana, Brazil
Ann Thorac Surg 90:1854-60. 2010This study evaluates the early and midterm results of decellularized aortic valve allografts (DAVA) as an aortic valve replacement.
- Incidence of aortic complications in patients with bicuspid aortic valvesHector I Michelena
Division of Cardiovascular Disease, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
JAMA 306:1104-12. 2011Bicuspid aortic valve (BAV), the most common congenital heart defect, has been thought to cause frequent and severe aortic complications; however, long-term, population-based data are lacking.
- Thirty-day results of the SAPIEN aortic Bioprosthesis European Outcome (SOURCE) Registry: A European registry of transcatheter aortic valve implantation using the Edwards SAPIEN valveMartyn Thomas
St Thomas Hospital, London, UK
Circulation 122:62-9. 2010Transcatheter aortic valve implantation was developed to mitigate the mortality and morbidity associated with high-risk traditional aortic valve replacement...
- Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal diseaseElena Aikawa
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Room 5420, Charlestown, MA 02129, USA
Circulation 119:1785-94. 2009..Here, we used genetically modified mice and molecular imaging to test the hypothesis in vivo that cathepsin S (catS), a potent elastolytic proteinase, accelerates calcification in atherosclerotic mice with CRD induced by 5/6 nephrectomy...
- Bicuspid aortic valve is heritableLinda Cripe
Department of Pediatrics, Division of Cardiology, Cincinnati Children s Hospital, Ohio 45229, USA
J Am Coll Cardiol 44:138-43. 2004Previous studies have established familial clustering of bicuspid aortic valve (BAV), presumably indicating genetic inheritance...
- Percutaneous aortic valve implantation retrograde from the femoral arteryJohn G Webb
Division of Cardiology, St Paul s Hospital, Vancouver, British Columbia, Canada
Circulation 113:842-50. 2006Percutaneous aortic valve implantation by an antegrade transvenous approach has been described but is problematic. Retrograde prosthetic aortic valve implantation via the femoral artery has potential advantages...
- Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulate aortic valve calcificationJens J Kaden
First Department of Medicine Cardiology, Angiology, and Pneumology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theordor Kutzer Ufer 1 3, 68167 Mannheim, Germany
J Mol Cell Cardiol 36:57-66. 2004..Receptor Activator of Nuclear factor kappaB Ligand" (RANKL) and osteoprotegerin (OPG) are members of a cytokine system involved in bone turnover and vascular calcification. Their role in calcific AS is not known...
- Human aortic valve calcification is associated with an osteoblast phenotypeNalini M Rajamannan
Division of Cardiology, Northwestern University Feinberg School of Medicine, Northwestern University, 201 East Huron St, Galter Suite 10 240, Chicago, Ill 60611, USA
Circulation 107:2181-4. 2003..We hypothesized that the mechanism for aortic valve calcification is similar to skeletal bone formation and that this process is mediated by an osteoblast-like ..
- Abnormal aortic valve development in mice lacking endothelial nitric oxide synthaseT C Lee
Division of Cardiology, Terrence Donnelly Heart Center, St Michael s Hospital, University of Toronto, Ontario, Canada
Circulation 101:2345-8. 2000..Therefore, we investigated the role of endothelium-derived NO during cardiovascular development using mice deficient in eNOS...
- A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosisS Joanna Cowell
Department of Cardiology, Royal Infirmary, Edinburgh, United Kingdom
N Engl J Med 352:2389-97. 2005..We hypothesized that intensive lipid-lowering therapy would halt the progression of calcific aortic stenosis or induce its regression...
- Aortic root dilatation in young men with normally functioning bicuspid aortic valvesS Nistri
Sanitary Service, Regione Carabinieri Veneto, Via Brigata Padova 19, 35100 Padova, Italy
Heart 82:19-22. 1999To evaluate the dimensions of the aortic root in a selected population of young males with isolated normally functioning bicuspid aortic valve.
- Upregulation of the 5-lipoxygenase pathway in human aortic valves correlates with severity of stenosis and leads to leukotriene-induced effects on valvular myofibroblastsEdit Nagy
Center for Molecular Medicine, CMM L8 03, Karolinska University Hospital, Stockholm, Sweden
Circulation 123:1316-25. 2011The development of aortic valve stenosis is not only associated with calcification and extracellular matrix remodeling, but also with inflammation...
- Two-year outcomes after transcatheter or surgical aortic-valve replacementSusheel K Kodali
Columbia University Medical Center and New York Presbyterian Hospital, New York, NY 10032, USA
N Engl J Med 366:1686-95. 2012..However, longer-term follow-up is necessary to determine whether TAVR has prolonged benefits...
- Transcatheter aortic-valve replacement for inoperable severe aortic stenosisRaj R Makkar
Cedars Sinai Heart Institute, Los Angeles, USA
N Engl J Med 366:1696-704. 2012..Transcatheter aortic-valve replacement (TAVR) is the recommended therapy for patients with severe aortic stenosis who are not suitable candidates for surgery. The outcomes beyond 1 year in such patients are not known...
- Impact of myocardial fibrosis in patients with symptomatic severe aortic stenosisFrank Weidemann
University Clinic of Internal Medicine I Center for Cardiovascular Disease, University of Wurzburg, 97080 Wurzburg, Germany
Circulation 120:577-84. 2009..follow-up study, the effect of myocardial fibrosis on myocardial performance in symptomatic severe aortic stenosis was investigated, and the impact of fibrosis on clinical outcome after aortic valve replacement (AVR) was estimated.
- Long-term survival after the Bentall procedure in 206 patients with bicuspid aortic valveChristian D Etz
Department of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York, New York 10029, USA
Ann Thorac Surg 84:1186-93; discussion 1193-4. 2007The recognition that patients with a bicuspid aortic valve (BAV) are at risk for aorta-related death (rupture or dissection) has favored composite aortic root replacement in BAV patients who undergo aortic valve replacement for valve ..
- The bicuspid aortic valve: an integrated phenotypic classification of leaflet morphology and aortic root shapeB M Schaefer
Department of Medicine, Division of Cardiology, Seattle, WA, USA
Heart 94:1634-8. 2008To establish a classification of bicuspid aortic valve (BAV) that includes both leaflet morphology and aortic shape.
- Bicuspid aortic valve diseaseSamuel C Siu
Division of Cardiology, University of Western Ontario, London, Ontario, Canada
J Am Coll Cardiol 55:2789-800. 2010Bicuspid aortic valve (BAV) disease is the most common congenital cardiac defect. While the BAV can be found in isolation, it is often associated with other congenital cardiac lesions...
- Quantification of hemodynamic wall shear stress in patients with bicuspid aortic valve using phase-contrast MRIAlex J Barker
Department of Mechanical Engineering, University of Colorado, Boulder, CO 80309, USA
Ann Biomed Eng 38:788-800. 2010Bicuspid aortic valve (BAV) is often concomitant with aortic dilatation, aneurysm, and dissection...
- Usefulness of bicuspid aortic valve phenotype to predict elastic properties of the ascending aortaBenjamin M Schaefer
Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA
Am J Cardiol 99:686-90. 2007Bicuspid aortic valve (BAV) affects about 0.5% to 2% of the population and predisposes patients to aortic dilation and dissection. We hypothesized that aortic size and elastic properties are related to BAV phenotype...
- Percutaneous implantation of the CoreValve self-expanding valve prosthesis in high-risk patients with aortic valve disease: the Siegburg first-in-man studyEberhard Grube
Department of Cardiology Angiology, HELIOS Heart Center Siegburg, Ringstrasse 49, 53721 Siegburg, Germany
Circulation 114:1616-24. 2006The morbidity and mortality of surgical aortic valve replacement are increased in elderly patients with multiple high-risk comorbid conditions...
- Failure to prevent progressive dilation of ascending aorta by aortic valve replacement in patients with bicuspid aortic valve: comparison with tricuspid aortic valveHisayo Yasuda
Department of Cardiology, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
Circulation 108:II291-4. 2003Patients with bicuspid aortic valve (BAV) have been frequently complicated with ascending aortic dilation possibly because of hemodynamic burdens by aortic stenosis (AS) or regurgitation (AR) or congenital fragility of the aortic wall.
- Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysmsStephen H McKellar
Department of Surgery Division of Cardiovascular Surgery, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
J Thorac Cardiovasc Surg 134:290-6. 2007Bicuspid aortic valve is a common condition and is associated with a significantly increased risk of developing thoracic aortic aneurysms and acute aortic dissection...
- Cell-matrix interactions in the pathobiology of calcific aortic valve disease: critical roles for matricellular, matricrine, and matrix mechanics cuesJan Hung Chen
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada
Circ Res 108:1510-24. 2011The hallmarks of calcific aortic valve disease (CAVD) are the significant changes that occur in the organization, composition, and mechanical properties of the extracellular matrix (ECM), ultimately resulting in stiffened stenotic ..
- Transforming growth factor-beta1 mechanisms in aortic valve calcification: increased alkaline phosphatase and related eventsJocelyn N Clark-Greuel
Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
Ann Thorac Surg 83:946-53. 2007b>Aortic valve stenosis is the most frequent indication for valve replacement surgery, and is commonly associated with pathologic calcification...
- Natural history of asymptomatic patients with normally functioning or minimally dysfunctional bicuspid aortic valve in the communityHector I Michelena
Divisions of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Circulation 117:2776-84. 2008Bicuspid aortic valve is frequent and is reported to cause numerous complications, but the clinical outcome of patients diagnosed with normal or mildly dysfunctional valve is undefined.
- Clinical and pathophysiological implications of a bicuspid aortic valvePaul W M Fedak
Division of Cardiac Surgery, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada
Circulation 106:900-4. 2002
- Early experience with percutaneous transcatheter implantation of heart valve prosthesis for the treatment of end-stage inoperable patients with calcific aortic stenosisAlain Cribier
Department of Cardiology, Charles Nicolle Hospital, University of Rouen, Rouen, France
J Am Coll Cardiol 43:698-703. 2004..This study was done to assess the results of percutaneous heart valve (PHV) implantation in non-surgical patients with end-stage calcific aortic stenosis...
- Noncollagenous bone matrix proteins as a part of calcific aortic valve disease regulationVirva Pohjolainen
Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland
Hum Pathol 39:1695-701. 2008Clinically, calcific aortic valve disease is a progressive continuum from obstructive fibro(sclero)tic valve thickening to aortic stenosis...
- Cardiovascular morbidity and mortality in community-dwelling elderly individuals with calcification of the fibrous skeleton of the base of the heart and aortosclerosis (The Cardiovascular Health Study)Eddy Barasch
Department of Research and Education, St Francis Hospital, Roslyn, New York, USA
Am J Cardiol 97:1281-6. 2006In the elderly, mitral annular calcification (MAC) and aortic valve sclerosis (AVS) are associated with increased cardiovascular morbidity and mortality. Aortic annular calcification (AAC) commonly occurs with MAC...
- Surgical management of aortic root disease in Marfan syndrome: a systematic review and meta-analysisUmberto Benedetto
Department of Cardiac Surgery, University of Rome Sapienza, Policlinico S Andrea, Rome, Italy
Heart 97:955-8. 2011..Surgical treatment of aortic root aneurysm in Marfan syndrome (MFS) patients...
- Impact of valve prosthesis-patient mismatch on left ventricular mass regression following aortic valve replacementGiordano Tasca
Department of Cardiac Surgery, Poliambulanza Hospital, Brescia, Italy
Ann Thorac Surg 79:505-10. 2005Valve prosthesis-patient mismatch is a frequent problem in patients undergoing aortic valve replacement and its main hemodynamic consequence is to generate high transvalvular gradients through normally functioning prosthetic valves...
- Transcatheter valve implantation for patients with aortic stenosis: a position statement from the European Association of Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of PercuAlec Vahanian
Hopital Bichat, Paris, France
Eur Heart J 29:1463-70. 2008To critically review the available transcatheter aortic valve implantation techniques and their results, as well as propose recommendations for their use and development.
- Long-term risk of aortic events following aortic valve replacement in patients with bicuspid aortic valvesStephen H McKellar
Department of Surgery, Division of Cardiovascular Surgery, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Am J Cardiol 106:1626-33. 2010Bicuspid aortic valve (BAV) is associated with ascending aortopathy predisposing to aneurysmal dilatation and dissection, even after successful aortic valve replacement (AVR)...
- Aortic valve sclerosis and aortic atherosclerosis: different manifestations of the same disease? Insights from a population-based studyY Agmon
Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
J Am Coll Cardiol 38:827-34. 2001The aim of this study was to examine the association between atherosclerosis risk factors, aortic atherosclerosis and aortic valve abnormalities in the general population.
- The bicuspid aortic valveAlan C Braverman
Washington University School of Medicine, St Louis, Missouri 63110, USA
Curr Probl Cardiol 30:470-522. 2005The bicuspid aortic valve affects 1 to 2% of the population and may be complicated by aortic stenosis or aortic insufficiency and infective endocarditis...
- Percutaneous transarterial aortic valve implantation: what do we know?John Webb
St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada
Eur Heart J 32:140-7. 2011Transcatheter aortic valve implantation (TAVI) is assuming a major role in the routine management of patients with aortic stenosis...
- Aortic annulus evaluation in transcatheter aortic valve implantationAndrea Hutter
Clinic for Cardiovascular Surgery, German Heart Centre Munich, Munich, Germany
Catheter Cardiovasc Interv 76:1009-19. 2010We compared the annulus diameters measured by transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), and dual-source computed tomography (DSCT) before transcatheter aortic valve implantation (TAVI).
- Comparison between cardiovascular magnetic resonance and transthoracic Doppler echocardiography for the estimation of effective orifice area in aortic stenosisJulio Garcia
Quebec Heart and Lung Institute, Laval University, Quebec, Canada
J Cardiovasc Magn Reson 13:25. 2011..Cardiovascular magnetic resonance (CMR) has emerged as an alternative method for non-invasive estimation of valve EOA. The objective of this study was to assess the concordance between TTE and CMR for the estimation of valve EOA...
- Permanent pacemaker insertion after CoreValve transcatheter aortic valve implantation: incidence and contributing factors (the UK CoreValve Collaborative)M Z Khawaja
UK CoreValve Collaborative, Sussex Cardiac Centre, Brighton and Sussex University Hospital Trust, Eastern Road, Brighton, East Sussex, BN2 5BE, UK
Circulation 123:951-60. 2011Permanent pacemaker (PPM) requirement is a recognized complication of transcatheter aortic valve implantation...
- Assessment of valvular calcification and inflammation by positron emission tomography in patients with aortic stenosisMarc Richard Dweck
Centre for Cardiovascular Science, University of Edinburgh, Little France Crescent, Edinburgh, United Kingdom
Circulation 125:76-86. 2012..The pathophysiology of aortic stenosis is incompletely understood, and the relative contributions of valvular calcification and inflammation to disease progression are unknown...
- Transcatheter aortic valve implantation for high-risk patients with severe aortic stenosis: A systematic reviewTristan D Yan
Department of Cardiothoracic Surgery, The University of Sydney, Royal Prince Alfred Hospital, Sydney 2050, Australia
J Thorac Cardiovasc Surg 139:1519-28. 2010The present systematic review objectively assessed the safety and clinical effectiveness of transcatheter aortic valve implantation for patients at high surgical risk with severe aortic stenosis.
- Relationship between the logistic EuroSCORE and the Society of Thoracic Surgeons Predicted Risk of Mortality score in patients implanted with the CoreValve ReValving system--a Bern-Rotterdam StudyNicolo Piazza
Interventional Cardiology Department, Erasmus Medical Center, Thoraxcenter, s Gravendijkwal 230, Rotterdam, The Netherlands
Am Heart J 159:323-9. 2010..of Mortality (STS) score, are commonly used to identify high-risk or "inoperable" patients for transcatheter aortic valve implantation (TAVI)...
- Endothelial function, carotid-femoral stiffness, and plasma matrix metalloproteinase-2 in men with bicuspid aortic valve and dilated aortaNikolaos Tzemos
Division of Cardiology, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Am Coll Cardiol 55:660-8. 2010This study sought to examine the relationship between proximal aortic dilation and systemic vascular function in men with bicuspid aortic valve (BAV).
- Biomechanical implications of the congenital bicuspid aortic valve: a finite element study of aortic root function from in vivo dataCarlo A Conti
Department of Bioengineering, Politecnico di Milano, Milan, Italy
J Thorac Cardiovasc Surg 140:890-6, 896.e1-2. 2010..By using imaging-derived data, finite element models were developed to quantify aortic valve and root biomechanical alterations associated with bicuspid geometry.
- Outcomes in adults with bicuspid aortic valvesNikolaos Tzemos
Peter Munk Cardiac Centre and Toronto Congenital Cardiac Centre for Adults, University Health Network, University of Toronto, Toronto, Ontario, Canada
JAMA 300:1317-25. 2008Bicuspid aortic valve is the most common congenital cardiac anomaly in the adult population. Cardiac outcomes in a contemporary population of adults with bicuspid aortic valve have not been systematically determined.
- Valve configuration determines long-term results after repair of the bicuspid aortic valveDiana Aicher
Department of Thoracic and Cardiovascular Surgery, University Hospitals Homburg, Homburg, Germany
Circulation 123:178-85. 2011Reconstruction of the regurgitant bicuspid aortic valve has been performed for >10 years, but there is limited information on long-term results. We analyzed our results to determine the predictors of suboptimal outcome.
- Refining molecular pathways leading to calcific aortic valve stenosis by studying gene expression profile of normal and calcified stenotic human aortic valvesYohan Bosse
Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, Pavillon Margeritte d Youville, Y4190, 2725, Chemin Sainte Foy, Quebec City, Quebec, Canada
Circ Cardiovasc Genet 2:489-98. 2009Calcific aortic valve stenosis (AS) is a major societal and economic burden that is rising after the current shift toward an older population...
- Should the ascending aorta be replaced more frequently in patients with bicuspid aortic valve disease?Michael A Borger
Division of Cardiovascular Surgery, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
J Thorac Cardiovasc Surg 128:677-83. 2004The optimal diameter at which replacement of the ascending aorta should be performed in patients with bicuspid aortic valve disease is not known.
- Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatationPaul W M Fedak
Division of Cardiac Surgery, University of Toronto and Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
J Thorac Cardiovasc Surg 126:797-806. 2003Patients with bicuspid aortic valve malformations are at an increased risk of aortic dilatation, aneurysm formation, and dissection...
- Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trialNeil J Howell
Department of Cardiothoracic Surgery, University Hospital Birmingham, Edgbaston, Birmingham, UK
Circulation 123:170-7. 2011Patients undergoing aortic valve replacement for critical aortic stenosis often have significant left ventricular hypertrophy...
- Synergistic effects of cyclic tension and transforming growth factor-beta1 on the aortic valve myofibroblastW David Merryman
Engineered Tissue Mechanics Laboratory, Department of Bioengineering and the McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
Cardiovasc Pathol 16:268-76. 2007Phenotypically, aortic valve interstitial cells are dynamic myofibroblasts, appearing contractile and activated in times of development, disease, and remodeling...
- Differential immediate-early gene responses to elevated pressure in porcine aortic valve interstitial cellsJames N Warnock
Agricultural and Biological Engineering, Mississippi State University, Box 9632, Mississippi State, MS 39762 9632, USA
J Heart Valve Dis 15:34-41; discussion 42. 2006Cardiovascular risk factors are believed to play a role in the pathogenesis of aortic valve disease...
- Elevated cyclic stretch induces aortic valve calcification in a bone morphogenic protein-dependent mannerKartik Balachandran
The Wallace H Coulter School of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Dr, Suite 1121, Atlanta, GA 30332 0535, USA
Am J Pathol 177:49-57. 2010Calcified aortic valve (AV) cusps have increased expression of bone morphogenic proteins (BMPs) and transforming growth factor-beta1 (TGF-beta1)...
- Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve diseaseKartik Balachandran
The Wallace H Coulter School of Biomedical Engineering, Georgia Inst of Technology, 313 Ferst Dr, Ste 1121, Atlanta, GA 30332 0535, USA
Am J Physiol Heart Circ Physiol 296:H756-64. 2009Matrix metalloproteinases (MMPs) and cathepsins are proteolytic enzymes that are upregulated in diseased aortic valve cusps...
- Multivariable prediction of in-hospital mortality associated with aortic and mitral valve surgery in Northern New EnglandEdward R Nowicki
Dartmouth Medical School, Hanover, New Hampshire 03756, USA
Ann Thorac Surg 77:1966-77. 2004..Development of reliable prediction rules requires large data sets with appropriate risk factors that are available before surgery...
- Patient-prosthesis mismatch does not affect survival following aortic valve replacementNeil J Howell
Department of Cardiothoracic Surgery, University Hospital NHS Foundation Trust, Birmingham, UK
Eur J Cardiothorac Surg 30:10-4. 2006..has been reported to increase perioperative mortality and reduce postoperative survival in patients undergoing aortic valve replacement (AVR)...
- Comparison of aortic root dimensions and geometries before and after transcatheter aortic valve implantation by 2- and 3-dimensional transesophageal echocardiography and multislice computed tomographyArnold C T Ng
Department of Cardiology, The Department of Cardiothoracic Surgery, and the Department of Radiology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
Circ Cardiovasc Imaging 3:94-102. 2010..We assessed agreements between 2D and 3D TEE measurements with multislice computed tomography (MSCT) and changes in annular/LVOT areas and geometries after transcatheter aortic valve implantations (TAVI).
- Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosisBo Jian
Cardiology Research Laboratory, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
Ann Thorac Surg 75:457-65; discussion 465-6. 2003b>Aortic valve stenosis characteristically progresses due to cuspal calcification, often necessitating valve replacement surgery...
- Aortic valve endothelial cells undergo transforming growth factor-beta-mediated and non-transforming growth factor-beta-mediated transdifferentiation in vitroG Paranya
Department of Surgery, Children's Hospital, Boston, Massachusetts 02115, USA
Am J Pathol 159:1335-43. 2001..of transdifferentiation were identified in clonally derived endothelial cell populations isolated from ovine aortic valve leaflets...
- Congenital quadricuspid aortic valve: report of nine surgical casesGoichi Yotsumoto
Second Department of Surgery, Kagoshima University, Faculty of Medicine, Sakuragaoka, Kagoshima, Japan
Ann Thorac Cardiovasc Surg 9:134-7. 2003We report the clinicopathologic characteristics of the congenital quadricuspid aortic valve necessitating surgery. Among 616 patients for whom we performed an aortic valve operation over the past 20 years, nine patients (1...
- Tissue engineering of cardiac valve prostheses I: development and histological characterization of an acellular porcine scaffoldCatherine Booth
Division of Microbiology, University of Leeds, UK
J Heart Valve Dis 11:457-62. 2002..The study aim was to optimize a protocol to produce a porcine acellular matrix scaffold for use in developing a tissue-engineered heart valve...
- Notch1 represses osteogenic pathways in aortic valve cellsVishal Nigam
Gladstone Institute of Cardiovascular Disease and Departments of Pediatrics, University of California, San Francisco, CA 94158, USA
J Mol Cell Cardiol 47:828-34. 2009..We reported two families in which heterozygous mutations in NOTCH1 caused bicuspid aortic valve and severe aortic valve calcification...
- Evaluation of anatomic valve opening and leaflet morphology in aortic valve bioprosthesis by using multidetector CT: comparison with transthoracic echocardiographyFabien Chenot
Divisions of Cardiology and Radiology Cliniques Universitaires St Luc, Universite Catholique de Louvain, Avenue Hippocrate 10 2881, B 1200 Brussels, Belgium
Radiology 255:377-85. 2010To prospectively determine whether cardiac-gated multidetector computed tomography (CT) allows visualization of aortic valve leaflets after bioprosthetic aortic valve replacement (AVR), to provide an accurate method for measuring the ..
- Late outcomes for aortic valve replacement with the Carpentier-Edwards pericardial bioprosthesis: up to 17-year follow-up in 1,000 patientsR Scott McClure
Division of Cardiac Surgery, Brigham and Women s Hospital, Boston, Massachusetts, USA
Ann Thorac Surg 89:1410-6. 2010This study reviews a single institution experience with the Carpentier-Edwards pericardial aortic valve bioprosthesis, concentrating on late outcomes.
- Novel missense mutations (p.T596M and p.P1797H) in NOTCH1 in patients with bicuspid aortic valveSalah A Mohamed
Department of Cardiac Surgery, University of Schleswig Holstein, Campus Luebeck, Germany
Biochem Biophys Res Commun 345:1460-5. 2006The bicuspid aortic valve (BAV) is the most common congenital cardiac malformation, occurring in 1-2% of the population...
- Dilation of the pulmonary autograft after the Ross procedureT E David
Divisions of Cardiovascular Surgery and Cardiology of Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
J Thorac Cardiovasc Surg 119:210-20. 2000..Dilation of pulmonary autograft after the Ross procedure is being recognized with increasing frequency. This study was undertaken to examine the extent of this problem and factors that may be associated with it...
- Endothelium-dependent regulation of the mechanical properties of aortic valve cuspsIsmail El-Hamamsy
Tissue Engineering Department, Harefield Heart Science Centre, National Heart and Lung Institute, Imperial College London, Harefield, United Kingdom
J Am Coll Cardiol 53:1448-55. 2009The aim of this study was to evaluate the role of valve endothelium in regulating the mechanical properties of aortic valve cusps.
- Bicuspid aortic valve: four-dimensional MR evaluation of ascending aortic systolic flow patternsMichael D Hope
Department of Radiology, University of California San Francisco, 505 Parnassus Ave, Box 0628, San Francisco, CA 94143 0628, USA
Radiology 255:53-61. 2010..phase-contrast magnetic resonance (MR) imaging, also called four-dimensional flow MR imaging, to evaluate systolic blood flow patterns in the ascending aorta that may predispose patients with a bicuspid aortic valve (BAV) to aneurysm.
- Morphometric analysis of aortic media in patients with bicuspid and tricuspid aortic valveMatthias Bauer
Deutsches Herzzentrum Berlin, Germany
Ann Thorac Surg 74:58-62. 2002..The aim of this study was to analyze whether or not there is any histologic difference in the aortic media of patients with a bicuspid aortic valve or a tricuspid aortic valve.
- Altered shear stress stimulates upregulation of endothelial VCAM-1 and ICAM-1 in a BMP-4- and TGF-beta1-dependent pathwayPhilippe Sucosky
Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556 5637, USA
Arterioscler Thromb Vasc Biol 29:254-60. 2009Hemodynamics has been associated with aortic valve (AV) inflammation, but the underlying mechanisms are not well understood...
- Evidence in favor of linkage to human chromosomal regions 18q, 5q and 13q for bicuspid aortic valve and associated cardiovascular malformationsLisa J Martin
Center for Epidemiology and Biostatistics, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Hum Genet 121:275-84. 2007..The aim of this study was to identify regions of the genome that harbor genes influencing inheritance of bicuspid aortic valve (BAV) and/or associated cardiovascular malformation (CVM)...
- Dilatation of the ascending aorta in paediatric patients with bicuspid aortic valve: frequency, rate of progression and risk factorsA E Warren
Division of Pediatric Cardiology, Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
Heart 92:1496-500. 2006To describe the incidence and rate of dilatation of the ascending aorta in children with bicuspid aortic valve (BAV) and to determine factors that predict rapid aortic dilatation.
- Observed and relative survival after aortic valve replacementP Kvidal
Department of Cardiology, University Hospital, Uppsala, Sweden
J Am Coll Cardiol 35:747-56. 2000We sought to evaluate the effects of a number of factors that can potentially determine the optimal time for aortic valve replacement (AVR) and the observed and relative survival after the operation.
- Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient miceKatsuhiro Hanada
Department of Cell Biology and Genetics, Erasmus MC, Rotterdam, The Netherlands
Circ Res 100:738-46. 2007..They display thickened aortic valvular leaflets that are associated with aortic valve stenosis and insufficiency...
- Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valvesCraig A Simmons
Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia PA 19104, USA
Circ Res 96:792-9. 2005Calcific aortic valve sclerosis involves inflammatory processes and occurs preferentially on the aortic side of endothelialized valve leaflets...
- Predictors of ascending aortic dilatation with bicuspid aortic valve: a wide spectrum of disease expressionAlessandro Della Corte
Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, V Monaldi Hospital, Via L Bianchi, 80131 Naples, Italy
Eur J Cardiothorac Surg 31:397-404; discussion 404-5. 2007This study aimed to describe the features and identify the predictors of ascending aorta dilatation in patients with congenital bicuspid aortic valve (BAV).
- Paradoxical low-flow, low-gradient severe aortic stenosis despite preserved ejection fraction is associated with higher afterload and reduced survivalZeineb Hachicha
Laval Hospital Research Center Quebec Heart Institute, Department of Medicine, Laval University, Quebec, Canada
Circulation 115:2856-64. 2007..and current clinical observations suggest that some patients with severe aortic stenosis on the basis of aortic valve area may paradoxically have a relatively low gradient despite the presence of a preserved left ventricular (LV) ..
- Role of multislice computed tomography in transcatheter aortic valve replacementDavid A Wood
Division of Cardiology, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Am J Cardiol 103:1295-301. 2009Transcatheter aortic valve replacement (TAVR) required precise knowledge of the anatomic dimensions and physical characteristics of the aortic valve, annulus, and aortic root...
- Comparison of different decellularization procedures of porcine heart valvesM T Kasimir
Department of Cardiothoracic Surgery and Ludwig Boltzmann Institute for Cardiosurgical Research, University of Vienna, Vienna, Austria
Int J Artif Organs 26:421-7. 2003..Tissue engineering of heart valves should avoid the disadvantages of conventional prostheses. In this study we tested different decellularization procedures for their potential of cell removal and their ability to preserve the matrix...
- To operate or not on elderly patients with aortic stenosis: the decision and its consequencesB J Bouma
Department of Cardiology, Academic Medical Centre, University of Amsterdam, PO Box 2700, 1100 DE Amsterdam, The Netherlands
Heart 82:143-8. 1999..To evaluate the application of guidelines in the decision making process leading to medical or surgical treatment for aortic stenosis in elderly patients...
- Study on decellularized porcine aortic valve/poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) hybrid heart valve in sheep modelSong Wu
Department of Cardiovascular Surgery, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
Artif Organs 31:689-97. 2007..The hybrid valve may provide superior valve replacement with current techniques...
- Cost-effectiveness of transcatheter aortic valve replacement compared with standard care among inoperable patients with severe aortic stenosis: results from the placement of aortic transcatheter valves (PARTNER) trial (Cohort B)Matthew R Reynolds
Saint Luke s Mid America Heart Institute, University of Missouri Kansas City School of Medicine, Kansas City, MO 64111, USA
Circulation 125:1102-9. 2012In patients with severe aortic stenosis who cannot have surgery, transcatheter aortic valve replacement (TAVR) has been shown to improve survival and quality of life compared with standard therapy, but the costs and cost-effectiveness of ..
- Comparison of two-dimensional and three-dimensional imaging techniques for measurement of aortic annulus diameters before transcatheter aortic valve implantationErtunc Altiok
Department of Cardiology, University Hospital RWTH Aachen, Aachen, Germany
Heart 97:1578-84. 2011..3D) imaging techniques are used for procedure planning and selection of prosthesis size before transcatheter aortic valve implantation...
- Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2Xiaoping Yang
Division of Cardiothoracic Surgery, Department of Surgery, University of Colorado Denver, Denver, CO, USA
J Am Coll Cardiol 53:491-500. 2009Our aim was to determine whether aortic valve interstitial cells (AVICs) and pulmonary valve interstitial cells (PVICs) differ in expression of Toll-like receptor (TLR)2 and TLR4, response to TLR agonists, and osteogenic phenotypic changes...
- Transforming growth factor-beta receptor type II mutation in a patient with bicuspid aortic valve disease and intraoperative aortic dissectionEvaldas Girdauskas
Department of Cardiac Surgery, Heart Center, Zentralklinik Bad Berka, Bad Berka, Germany
Ann Thorac Surg 91:e70-1. 2011We report on a patient with familial bicuspid aortic valve disease operated on for proximal aortic aneurysm. The surgery was complicated by intraoperative aortic dissection...
- Absence of TGFBR1 and TGFBR2 mutations in patients with bicuspid aortic valve and aortic dilationCammon B Arrington
Department of Pediatrics, Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah, USA
Am J Cardiol 102:629-31. 2008..Because bicuspid aortic valve (BAV) is a congenital heart defect in patients with Loeys-Dietz syndrome, this study was conducted to ..
- Combining dynamic stretch and tunable stiffness to probe cell mechanobiology in vitroAngela M Throm Quinlan
Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts, United States of America
PLoS ONE 6:e23272. 2011..As a demonstration of the system, porcine aortic valve interstitial cells (VIC) and human mesenchymal stem cells (hMSC) were plated on soft and stiff substrates ..
- Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategiesRosario V Freeman
Division of Cardiology, Department of Medicine, University of Washington School of Medicine, Seattle, Wash 98195 6422, USA
Circulation 111:3316-26. 2005
- Progress and current status of percutaneous aortic valve replacement: results of three device generations of the CoreValve Revalving systemEberhard Grube
Departments of Cardiology, Cardiac Surgery, and Anaesthesiology, HELIOS Heart Center Siegburg, Ringstrasse 49, Siegburg, Germany
Circ Cardiovasc Interv 1:167-75. 2008Percutaneous aortic valve replacement is a new emerging technology for interventional treatment of severe aortic valve stenosis in surgical high-risk patients...
- Transcatheter aortic valve implantation: role of multi-detector row computed tomography to evaluate prosthesis positioning and deployment in relation to valve functionVictoria Delgado
Department of Cardiology and Cardiothoracic Surgery, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, The Netherlands
Eur Heart J 31:1114-23. 2010Aortic regurgitation after transcatheter aortic valve implantation (TAVI) is one of the most frequent complications. However, the underlying mechanisms of this complication remain unclear...
- Targeting Cell Death to Prevent Ventricular Remodeling and Heart FailureAbhinav Diwan; Fiscal Year: 2011..Nearly one third of the Veterans have ischemic heart disease and another third have hypertension and/or aortic valve stenosis, which cause heart failure...
- Novel Biomarkers in Aortic Aneurysms and Acute Aortic DissectionJENNIFER E contact VAN EYK; Fiscal Year: 2010..in the ascending part of the thoracic aorta since it may lead to global myocardial ischemia by compromising the aortic valve and blood flow through the coronary arteries...
- Shared Mechanisms of Valvular and Vascular CalcificationJOEL DAVID MORRISETT; Fiscal Year: 2012DESCRIPTION (provided by applicant): Calcific aortic valve disease (CAVD) is a degenerative disease for which the only treatment is surgical valve replacement...
- Control of Cardiogenesis by microRNA EditingKazuko Nishikura; Fiscal Year: 2010..ADAR2 expression is detected in the aortic sac at E10.5 and selected regions of embryonic heart including aortic valve at E14.5...
- Intravascular Cardiac Assist System for Decompression and RecoveryCAITLYN J BOSECKER; Fiscal Year: 2010..it successfully and consistently ejected 30 ml of blood during systole after the native ventricle opened the aortic valve and completed this ejection before the valve closed...
- Regulation of Periostin by TGFbeta and BMP in Heart DevelopmentThomas Doetschman; Fiscal Year: 2010..In humans POSTN protein is reduced in pediatric patients with bicuspid aortic valve. In adult valvular diseases mutations are found in TGF2 receptor genes (syndromic valve disease) and in the ..
- Tissue Engineered Aortic Heart Valves: Scaffolds and Stem CellsDAN TEODOR SIMIONESCU; Fiscal Year: 2013..we propose to develop partially stabilized collagen scaffolds that structurally and functionally mimic the aortic valve fibrosa, ventricularis and spongiosa layers, to assemble them into tri-layered constructs shaped in the form of ..
- Tissue Engineering Strategies: Effects on Valvular Interstitial Cell MetabolismKATHRYN JANE GRANDE-ALLEN; Fiscal Year: 2012..cells (VICs), especially as they relate to the tissue engineering of valves and the development of calcific aortic valve disease. Nonetheless, there has been scant investigation into the metabolism of valve cells...
- BMP2 Gene Regulation in Calcific Aortic Valve DiseaseMelissa B Rogers; Fiscal Year: 2013DESCRIPTION (provided by applicant): Congenital valve defects promote Calcific Aortic Valve Disease (CAVD). Bone morphogenetic protein 2 (BMP2) is a key signal in valve development...
- Endocrine Regulation of Calcific Aortic Valve Sclerosis: PTH/PTHRP Receptor SignaDwight A Towler; Fiscal Year: 2013..Therapeutic strategies focused solely on statin-based intervention have been ineffective in treating calcific aortic valve disease (CAVD). Type I diabetes (T2DM) and metabolic syndrome are major contributors to CAVD risk...
- Role of Inhibitory SMADs in Calcific Aortic Valve DiseaseYin Tintut; Fiscal Year: 2013DESCRIPTION (provided by applicant): Role of Inhibitory SMADs in Calcific Aortic Valve Disease Calcific aortic valve disease (CAVD) is associated epidemiologically with hyperlipidemia, the biological effects of which appear to occur ..
- ROS Mechanisms in BAV AortopathyTHOMAS GILLETTE GLEASON; Fiscal Year: 2013..ROS) accumulation in aortic smooth muscle cells (SMCs) mediates the aortopathy in patients with bicuspid aortic valve (BAV)...
- Mechanisms of Circadian Rhythmicity in CLOCK-Deficient MiceDAVID RAYMOND WEAVER; Fiscal Year: 2013..occurs with aging, following trauma, and in genetic and idiopathic forms), to age-related aortic stenosis, and aortic valve calcification (which is a prominent complication limiting surgical repair of the heart and cardiac valves)...
- AGE/RAGE Interaction in Patients with Pressure Overload-Induced Heart FailureMichael R Zile; Fiscal Year: 2013..provided by applicant): In response to the chronic pressure-overload caused by arterial hypertension or aortic valve stenosis, the myocardium undergoes hypertrophic remodeling that results in the development of left ventricular ..
- Exome Sequencing in Familial Cardiovascular MalformationsKIM LEWIS MCBRIDE; Fiscal Year: 2012..variation leading to a subgroup of CVMs, the left ventricular outflow tract (LVOT) malformations that includes aortic valve stenosis, coarctation of the aorta, and hypoplastic left heart syndrome...
- Role of Lrp5/Beta-Catenin in Aortic Valve CalcificationNalini M Rajamannan; Fiscal Year: 2011DESCRIPTION (provided by applicant): Aortic Valve Stenosis is a common consequence of the traditional risk factors for vascular atherosclerosis including: hypertension, hypercholesterolemia, smoking, increased BMI, aging and diabetes...
- Biomimetic micro-structured hydrogel scaffolds for tissue engineered heart valvesJennifer L West; Fiscal Year: 2013..methodologies to generate advanced 3D hydrogels that mimic the complex microstructure and material behavior of aortic valve tissues...
- Basic Mechanisms of Human Calcific Aortic Valve DiseaseGordon S Huggins; Fiscal Year: 2013DESCRIPTION (provided by applicant): Progressive calcific aortic valve disease (CAVD) is characterized by calcium deposition in the valve cusps as well as frank bone formation...
- Role of SIRT6 in calcific aortic valve diseaseJordan D Miller; Fiscal Year: 2013..Hemodynamically significant aortic valve stenosis affects 3% of the population over age 65...
- Shear stress, endothelial miRNAs, and AV calcificationAjit P Yoganathan; Fiscal Year: 2013DESCRIPTION (provided by applicant): Calcific aortic valve (AV) disease is a major cause of cardiac-related deaths worldwide and is a strong risk factor for additional cardiovascular events...
- 2012 Notch Signaling in Development, Regeneration &Disease Gordon ConferenceRaphael Kopan; Fiscal Year: 2012..alterations in Notch activity underlie several developmental syndromes (Alagille, Spondylocostal Dysostosis, aortic valve disease), adult onset diseases (CADASIL, various heart and valve malformations, muscular dystrophy, multiple ..
- Midcareer Mentoring Award for Patient Oriented Research in Geriatric CardiologyMathew S Maurer; Fiscal Year: 2013..using use of noninvasive pressure volume analysis and actigraphy in older adults undergoing percutaneous aortic valve replacement...
- A Novel Magnetic Resonance Imaging Marker of Myocardial FibrosisMichael Jerosch-Herold; Fiscal Year: 2013..in patients diagnosed with aortic stenosis with no previous history of coronary disease, who will undergo aortic valve replacement...
- Phase 2/3 of Covered Cheatham Platinum Stent for Aortic Wall InjuryRICHARD ELLIOT RINGEL; Fiscal Year: 2013..CoA can occur in isolation, in association with bicuspid aortic valve, or with major cardiac malformations...
- Probabilistic Modeling of Stenotic Aortic Valve InterventionWei Sun; Fiscal Year: 2013..Recently, minimally invasive transcatheter aortic valve (TAV) implantation has been investigated as an endovascular alternative to surgical valve replacement...
- Efficiencies for Outcome Ascertainment throughout the Total Product Life CycleJ Matthew Brennan; Fiscal Year: 2013..mechanisms of HOI ascertainment to the conduct of both 1) the longitudinal surveillance of transcatheter aortic valve replacement (TAVR) prostheses using available unique device identifiers (UDI), and 2) a pragmatic registry-..
- Stroke &cognition in surgical aortic stenosisMICHAEL ANDREW ACKER; Fiscal Year: 2011..The number of patients with this diagnosis and requiring aortic valve replacement(AVR) is growing rapidly with the aging of our population...
- Pro-inflammatory S100 protein as disease modifier in calcific aortic valve diseasMARION A HOFMANN-BOWMAN; Fiscal Year: 2013DESCRIPTION (provided by applicant): Calcific aortic valve disease is a growing health problem in our aging population...
- Imaging protease activation in calcific aortic valve diseaseMehran M Sadeghi; Fiscal Year: 2013..Aortic stenosis is the most common cause of valvular heart disease and calcific aortic valve disease (CAVD) is the most common cause of aortic stenosis...
- Functional Cardiovascular 4D MRI in Congenital Heart DiseaseCynthia K Rigsby; Fiscal Year: 2013..Bicuspid aortic valve (BAV), one of the most common forms of CHD, and single ventricle physiology (SVP), one of the most severe, are ..
- Genetic Etiology of Bicuspid Aortic Valve DiseaseSimon C Body; Fiscal Year: 2013DESCRIPTION (provided by applicant): Bicuspid aortic valve (BAV) is the most frequent congenital cardiac malformation, occurring in 0.5-1.2% of the US population...
- Twist1 regulation of valve progenitorsKatherine E Yutzey; Fiscal Year: 2013..by applicant): Heart valve replacement is the second most common cardiac surgery in the United States, and aortic valve sclerosis, an indicator of calcification, occurs in >25% of aged individuals...
- Development of transapical MVAD for heart failure therapyDaniel Tamez; Fiscal Year: 2013..The tMVAD is designed for intraventricular implantation with an outflow cannula that crosses the aortic valve. The device can be inserted via a minimally-invasive approach (subcostal incision or mini-thoracotomy) to ..
- Osteopontin: a Novel Biomarker for Calcific Aortic Valve DiseasesGiovanni Ferrari; Fiscal Year: 2010..Project Title: Osteopontin: a Novel Biomarker for Calcific Aortic Valve Diseases The calcification of the Aortic Valve represents a multifactorial process with varied underlying ..
- Surgeon Human Capital Depreciation Impacts on Resource Use and Patient OutcomesJason Hockenberry; Fiscal Year: 2011..used to treat coronary artery disease, CABG and PCI, as well as AAA repair surgery, carotid endarterectomy and aortic valve repair. There are two secondary aims...
- Cardioscopy New Platform for Less Invasive Surgery on the Beating HeartTomislav Mihaljevic; Fiscal Year: 2013..Cardioscope will be placed near the LV apex via a small thoracotomy or small subxiphoid incision or across the aortic valve via the carotid or femoral artery percutaneous approach...
- The Role of COX2 in the Progression of Calcific Aortic Valve DiseaseELAINE EMILY WIRRIG; Fiscal Year: 2013..The goal of the research proposed in this project is to identify the molecular mechanisms underlying aortic valve disease (AoVD) and potential therapeutic targets for the development of early medical treatment to halt AoVD ..
- Molecular and Cellular Mechanisms of Calcific Aortic StenosisBin Zhou; Fiscal Year: 2013DESCRIPTION (provided by applicant): Calcific aortic valve stenosis (CAVS) is the most common disease needed surgical valve replacement...
- Role of inflammatory response in aortic valve lesionsXianzhong Meng; Fiscal Year: 2013Summary Surgical valve replacement is the only available therapy for calcific aortic valve stenosis...
- TGF-beta1 activity in the aortic valveWILLIAM D MERRYMAN; Fiscal Year: 2013..with the molecular mechanisms of TGF-(31 activity and cardiovascular pathophysiology to appropriately examine aortic valve (AV) sclerosis. The Candidate will be mentored by Dr. Joanne E...
- Role of Animal Models in Transcatheter Valve InterventionWei Sun; Fiscal Year: 2012DESCRIPTION (provided by applicant): Minimally invasive transcatheter aortic valve (TAV) intervention holds promise for a large number of high- risk patients (advanced age and/or with co-morbidities) who might otherwise have limited or ..
- Bicuspid Valve Aortopathy: Feasibility of a Comparative Effectiveness StudyCRAIG STANFORD BROBERG; Fiscal Year: 2013..As many as 3 million Americans have or will have an enlarged thoracic aorta in the setting of a bicuspid aortic valve, even when valve function is normal...
- Serotonergic Receptor Targeted Therapy for Degenerative Aortic Valve DiseaseWILLIAM D MERRYMAN; Fiscal Year: 2013..Studies have shown that degenerative aortic valve disease affects over 25% of people over 65 years of age, leading to calcific aortic valve disease (CAVD) in 4-8 ..
- Patient-Specific Modeling for Analysis of Aortic AneurysmsCAITLIN MARIE MARTIN; Fiscal Year: 2013..to develop patient-specific finite element models for the analysis of ascending aortic aneurysm in bicuspid aortic valve (BAV) patients...
- Internet-Based Distributed Quantitative 4D Analysis of Aortic MR/MDCT ImagesXiangmin Zhang; Fiscal Year: 2013..quantitative 4D analysis of the entire aorta from MR/MDCT images for the entire aortic length between the aortic valve and the diaphragm...
- Shear Stress, BMP and Aortic Valve InflammationHanjoong Jo; Fiscal Year: 2010Inflammation and calcification are common features of the aortic valve (AV) diseases, which typically require surgical replacement of the valves...
- Wnt signaling in heart valve development and diseaseKatherine E Yutzey; Fiscal Year: 2013..by applicant): Heart valve replacement is the second most common cardiac surgery in the United States and aortic valve sclerosis occurs in >25% of aged individuals...
- The Role of Notch Signaling in ArrhythmogenesisSTACEY LYNN RENTSCHLER; Fiscal Year: 2013..including the pathogenesis of many malignancies, as well as cardiac developmental defects such as bicuspid aortic valve and tetralogy of Fallot. However, a role for Notch in arrhythmic phenotypes has not previously been described...
- Therapeutic Strategy to slow progression of calcific aortic valve stenosisHartzell V Schaff; Fiscal Year: 2013Hemodynamically significant calcific aortic valve stenosis (CAVS) affects 3% of the population over age 65, and patients with even moderate aortic valve stenosis (peak velocity of 3-4 m/sec) have a 5 year event-free survival of less than ..
- Tissue-engineered pulmonic valve grown from human cells for pediatric patientsRobert T Tranquillo; Fiscal Year: 2013..S. annually if this TEHV can subsequently be improved to withstand forces associated with the aortic valve position...
- Role of Osteoclastogenesis in Calcific Aortic Valve DiseaseCecilia M Giachelli; Fiscal Year: 2013..by applicant): Inflammation, fibrosis and ectopic calcification are common pathologies observed in calcific aortic valve disease (CAVD)...
- Genetic and Developmental Basis of Pediatric Aortic Valve Disease PathogenesisROBERT BRUCE HINTON; Fiscal Year: 2010..a 'bedside to bench to bedside" approach to investigate the genetic causes and pathogenesis of pediatric aortic valve disease...
- Surgical Planning Tool for Aortic Valve ReconstructionPedro J del Nido; Fiscal Year: 2013DESCRIPTION (provided by applicant): Aortic valve disease is the third most common congenital left heart lesion, affecting 8% of all children born with heart defects...
- Effects of hydroxyapatite mineralization and valve cell phenotypeJONATHAN TALBOT BUTCHER; Fiscal Year: 2013DESCRIPTION (provided by applicant): Proper function of the aortic valve is critically important for efficient cardiac performance...
- A Novel Polymeric Percutaneous Heart Valve ProsthesisSCOTT C CORBETT; Fiscal Year: 2010..polymeric trileaflet heart valve to a valve prosthesis that can be delivered percutaneously as a transcatheter aortic valve replacement...
- Aortic valve microcalcificationElena Aikawa; Fiscal Year: 2013..cell (VIC)-derived matrix vesicles, precursors of microcalcification, offering the novel mechanism of calcific aortic valve disease (CAVD)...
- Cell Signaling Mechanisms of Calcific Aortic Valve DiseaseKatherine E Yutzey; Fiscal Year: 2013DESCRIPTION (provided by applicant): Calcific Aortic Valve Disease (CAVD) occurs in >2% of the population over 65 years of age and often leads to valvular stenosis that necessitates valve replacement...
- Freeze-Dried, Viable Allogeneic Heart ValvesKelvin Brockbank; Fiscal Year: 2006..In this proposal, sheep aortic valve leaflet fibroblasts and aortic conduit smooth muscle cells will be used for optimization of freeze-drying, ..
- Fluid-structure simulation for prosthetic heart valvesKRISHNAN CHANDRAN; Fiscal Year: 2009Degeneration of heart valves with congenital malformations, such as bicuspid aortic valve (BAV) and associated pathology of the aortic apparatus (including the root, sinus, and the valve leaflets), is a common clinical problem resulting ..
- SUBENDOCARDIAL O2 SUPPLY AND DEMAND IN AORTIC STENOSISPeter Scholz; Fiscal Year: 1992..All studies will be conducted on anesthetized open chest dogs 6 months after creation of aortic valve stenosis as puppies...
- Development of a TAVI Device with a Reduced Crossing ProfileTodd N McAllister; Fiscal Year: 2013DESCRIPTION (provided by applicant): Transcatheter aortic valve implantation (TAVI) is a minimally invasive approach to valve replacement that has had a rapid and profound clinical impact...
- ADHESINS OF COAGULASE NEGATIVE STAPHYLOCOCCIGerald Pier; Fiscal Year: 1999..of PS/A-positive and -negative strains to spread from a contaminated intracardiac foreign body to adjacent aortic valve tissue; and finally, determining whether vaccination with PS/A, or passive infusion of an antibody to PS/A, ..
- Structural Analysis and Comparative Study of Surgical and Transcatheter Valve DevWei Sun; Fiscal Year: 2013..Since the transcathete aortic valve (TAV) is made of similar biomaterials and acts as an alternative to a surgical bioprosthetic valve in the same ..
- THE GENETIC ETIOLOGY OF HYPOPLASTIC LEFT HEART SYNDROMEPeter Bowers; Fiscal Year: 2004..which includes first trimester spontaneous abortion, HLHS, aortic and mitral stenosis, coarctation and bicuspid aortic valve. With 2 percent of the general population having a bicuspid aortic valve, these lesions are extremely common...
- TRANSLUMINAL ANGIOPLASTY-CONVENITAL HEART DISEASEJames Anderson; Fiscal Year: 1990..and right ventricles will be used to evaluate the relationship between acute altered mechanical loading via aortic valve occlusion...
- ELASTIN DAMAGE: MECHANISM OF BIOPROSTHETIC VALUE FAILUREIvan Vesely; Fiscal Year: 2002..addressed mechanical degeneration, and have focused on understanding the structure/function relationship of aortic valve cusp tissues...
- Micromechanics of the Aortic Valve:Durability TestingIvan Vesely; Fiscal Year: 2002b>Aortic valve disease is treated by replacing the diseased valve with either a mechanical or an animal tissue-based artificial heart valve. Unfortunately, neither device can provide good quality of life...
- A Composite Tissue-engineered Aortic Valve ProsthesisIvan Vesely; Fiscal Year: 2006b>Aortic valve disease is treated by replacing the diseased valve with either a mechanical or an animal tissue-based artificial heart valve. Unfortunately, neither device can provide good quality of life...