heart ventricles


Summary: The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.

Top Publications

  1. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
  2. pmc Transient regenerative potential of the neonatal mouse heart
    Enzo R Porrello
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 331:1078-80. 2011
  3. ncbi Alternans and spiral breakup in a human ventricular tissue model
    K H W J ten Tusscher
    Utrecht University, Department of Theoretical Biology, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Am J Physiol Heart Circ Physiol 291:H1088-100. 2006
  4. ncbi A model for human ventricular tissue
    K H W J ten Tusscher
    Department of Theoretical Biology, Utrecht University, 3584 CH Utrecht, The Netherlands
    Am J Physiol Heart Circ Physiol 286:H1573-89. 2004
  5. pmc Transmural dispersion of repolarization in failing and nonfailing human ventricle
    Alexey V Glukhov
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Circ Res 106:981-91. 2010
  6. ncbi Heart regeneration in zebrafish
    Kenneth D Poss
    Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Children s Hospital, 320 Longwood Avenue, Boston, MA 02115, USA
    Science 298:2188-90. 2002
  7. ncbi Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension
    Serge A van Wolferen
    Department of Pulmonary Diseases, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Eur Heart J 28:1250-7. 2007
  8. pmc Increased right ventricular repolarization gradients promote arrhythmogenesis in a murine model of Brugada syndrome
    Claire A Martin
    Physiological Laboratory, University of Cambridge, Downing Site, Cambridge, United Kingdom
    J Cardiovasc Electrophysiol 21:1153-9. 2010
  9. pmc A novel computational model of the human ventricular action potential and Ca transient
    Eleonora Grandi
    Department of Pharmacology, University of California, 451 Health Sciences Drive, GBSF Room 3513, Davis, CA 95616 8636, USA
    J Mol Cell Cardiol 48:112-21. 2010
  10. pmc Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
    John W Elrod
    Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:15560-5. 2007

Detail Information

Publications394 found, 100 shown here

  1. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
    ..We hypothesized that the results of contrast-enhanced MRI can be used to predict whether regions of abnormal ventricular contraction will improve after revascularization in patients with coronary artery disease...
  2. pmc Transient regenerative potential of the neonatal mouse heart
    Enzo R Porrello
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 331:1078-80. 2011
    ..Echocardiography performed 2 months after surgery revealed that the regenerated ventricular apex had normal systolic function. Thus, for a brief period after birth, the mammalian heart appears to have the capacity to regenerate...
  3. ncbi Alternans and spiral breakup in a human ventricular tissue model
    K H W J ten Tusscher
    Utrecht University, Department of Theoretical Biology, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Am J Physiol Heart Circ Physiol 291:H1088-100. 2006
    ..Therefore, we conclude that steep APD restitution-mediated instability is a potential mechanism for VF in the human heart...
  4. ncbi A model for human ventricular tissue
    K H W J ten Tusscher
    Department of Theoretical Biology, Utrecht University, 3584 CH Utrecht, The Netherlands
    Am J Physiol Heart Circ Physiol 286:H1573-89. 2004
    ..We conclude that the proposed model reproduces a variety of electrophysiological behaviors and provides a basis for studies of reentrant arrhythmias in human ventricular tissue...
  5. pmc Transmural dispersion of repolarization in failing and nonfailing human ventricle
    Alexey V Glukhov
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Circ Res 106:981-91. 2010
    ..Heterogeneous changes of repolarization within the midmyocardial population of ventricular cells have been considered an important contributor to the HF phenotype. However, there is limited electrophysiological data from the human heart...
  6. ncbi Heart regeneration in zebrafish
    Kenneth D Poss
    Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Children s Hospital, 320 Longwood Avenue, Boston, MA 02115, USA
    Science 298:2188-90. 2002
    ..These findings indicate that zebrafish will be useful for genetically dissecting the molecular mechanisms of cardiac regeneration...
  7. ncbi Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension
    Serge A van Wolferen
    Department of Pulmonary Diseases, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Eur Heart J 28:1250-7. 2007
    ..This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH)...
  8. pmc Increased right ventricular repolarization gradients promote arrhythmogenesis in a murine model of Brugada syndrome
    Claire A Martin
    Physiological Laboratory, University of Cambridge, Downing Site, Cambridge, United Kingdom
    J Cardiovasc Electrophysiol 21:1153-9. 2010
    ..We compared activation latencies and spatial differences in action potential recovery between different ventricular regions in a murine Scn5a+/- BrS model, and investigated the effect of flecainide and quinidine upon these...
  9. pmc A novel computational model of the human ventricular action potential and Ca transient
    Eleonora Grandi
    Department of Pharmacology, University of California, 451 Health Sciences Drive, GBSF Room 3513, Davis, CA 95616 8636, USA
    J Mol Cell Cardiol 48:112-21. 2010
    ..We conclude that this model provides a useful framework to explore excitation-contraction coupling mechanisms and repolarization abnormalities at the single myocyte level...
  10. pmc Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
    John W Elrod
    Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:15560-5. 2007
  11. pmc A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates
    Aman Mahajan
    UCLA Cardiovascular Research Laboratory, Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Biophys J 94:392-410. 2008
  12. ncbi Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden
    Teresa S M Tsang
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Cardiol 90:1284-9. 2002
    ..In patients without a history of atrial arrhythmias or valvular heart disease, LA volume expressed the severity of diastolic dysfunction and provided an index of cardiovascular risk and disease burden...
  13. pmc Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation
    Thomas O'Hara
    Cardiac Bioelectricity and Arrhythmia Center, Department of Biomedical Engineering, Washington University in St Louis, St Louis, Missouri, USA
    PLoS Comput Biol 7:e1002061. 2011
    ..APD shortening during restitution was primarily dependent on reduced late Na(+) and I(CaL) currents due to inactivation at short diastolic intervals, with additional contribution from elevated I(Kr) due to incomplete deactivation...
  14. pmc Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation
    Eleonora Grandi
    Department of Pharmacology, University of California, Davis, 451 Health Sciences Dr, GBSF Room 3513, Davis, CA 95616 8636, USA
    Circ Res 109:1055-66. 2011
    ..Understanding atrial fibrillation (AF) requires integrated understanding of ionic currents and Ca2+ transport in remodeled human atrium, but appropriate models are limited...
  15. pmc Autologous transplantation of adipose-derived mesenchymal stem cells markedly reduced acute ischemia-reperfusion lung injury in a rodent model
    Cheuk Kwan Sun
    Department of Emergency Medicine, E Da Hospital, I Shou University, Kaohsiung, Taiwan
    J Transl Med 9:118. 2011
    ..This study tested the hypothesis that autologous transplantation of adipose-derived mesenchymal stem cells (ADMSCs) can effectively attenuate acute pulmonary ischemia-reperfusion (IR) injury...
  16. ncbi Speckle-tracking echocardiography correctly identifies segmental left ventricular dysfunction induced by scarring in a rat model of myocardial infarction
    Zoran B Popovic
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Physiol Heart Circ Physiol 292:H2809-16. 2007
    ..0001) than on percent fibrosis (P<0.002). STE correctly identifies segmental LV dysfunction induced by scarring that follows myocardial infarction in rats...
  17. pmc Pulmonary arterial remodeling induced by a Th2 immune response
    Eleen Daley
    St Luke s Roosevelt Hospital, New York, NY 10019, USA
    J Exp Med 205:361-72. 2008
  18. ncbi The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field
    Michael P Verzi
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 2240, USA
    Dev Biol 287:134-45. 2005
    ..Finally, the Cre transgenic mice described here will be a crucial tool for conditional gene inactivation exclusively in the anterior heart field and its derivatives...
  19. ncbi Cardiac connexins and impulse propagation
    John A Jansen
    Department of Medical Physiology, Division Heart and Lungs, University Medical Center Utrecht, The Netherlands
    J Mol Cell Cardiol 48:76-82. 2010
    ..This review will follow the cardiac impulse on its path through the heart and recapitulate the role of the different connexins in the different cardiac compartments...
  20. pmc Foxn4 directly regulates tbx2b expression and atrioventricular canal formation
    Neil C Chi
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, California 94158, USA
    Genes Dev 22:734-9. 2008
    ..sli/foxn4 is expressed in the AV canal, and its encoded product binds to a highly conserved tbx2 enhancer domain that contains Foxn4- and T-box-binding sites, both necessary to regulate tbx2b expression in the AV canal...
  21. pmc A mathematical treatment of integrated Ca dynamics within the ventricular myocyte
    Thomas R Shannon
    Department of Molecular Biophysics and Physiology, Rush University, Chicago, Illinois, USA
    Biophys J 87:3351-71. 2004
    ..We conclude that this model is more robust than many previously existing models and reproduces many experimental results using parameters based largely on experimental measurements in myocytes...
  22. pmc Patient-specific modeling of dyssynchronous heart failure: a case study
    Jazmin Aguado-Sierra
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
    Prog Biophys Mol Biol 107:147-55. 2011
  23. ncbi Midwall fibrosis is an independent predictor of mortality in patients with aortic stenosis
    Marc R Dweck
    Royal Brompton Hospital, London, United Kingdom
    J Am Coll Cardiol 58:1271-9. 2011
    ..The goal of this study was to assess the prognostic significance of midwall and infarct patterns of late gadolinium enhancement (LGE) in aortic stenosis...
  24. ncbi Myocardial strain measurement with 2-dimensional speckle-tracking echocardiography: definition of normal range
    Thomas H Marwick
    University of Queensland, Department of Medicine, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    JACC Cardiovasc Imaging 2:80-4. 2009
    ..However, there was significant segmental variation of regional strain to necessitate the use of site-specific normal ranges...
  25. pmc Models of cardiac electromechanics based on individual hearts imaging data: image-based electromechanical models of the heart
    Viatcheslav Gurev
    Institute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, 3400 N Charles St, CSEB Room 218, Baltimore, MD 21218, USA
    Biomech Model Mechanobiol 10:295-306. 2011
    ..The utility of the model is demonstrated in an example simulation of contraction during sinus rhythm using a model of the normal canine ventricles...
  26. pmc Hydrogen sulfide attenuates cardiac dysfunction in a rat model of heart failure: a mechanism through cardiac mitochondrial protection
    Xianli Wang
    Department of Pharmacology, School of Pharmacy and Institute of Biomedical Sciences, Fudan University, Shanghai, People s Republic of China
    Biosci Rep 31:87-98. 2011
    ..Histological observation by TUNEL and EM proved that NaHS inhibited cardiac apoptosis in HF hearts and improved mitochondrial derangements, but that PAG aggravated those indices. Hence, H2S has protective effects in HF rats...
  27. doi Right ventricular function in cardiovascular disease, part I: Anatomy, physiology, aging, and functional assessment of the right ventricle
    Francois Haddad
    Division of Cardiovascular Medicine, Stanford University, 770 Welch Rd, Suite 400, Palo Alto, CA 94304 5715, USA
    Circulation 117:1436-48. 2008
  28. ncbi Cardiac morphology and blood pressure in the adult zebrafish
    N Hu
    University of Utah, Department of Pediatrics, Salt Lake City, Utah 84132, USA
    Anat Rec 264:1-12. 2001
    ..These data serve as a framework for structure-function investigations of the zebrafish cardiovascular system...
  29. ncbi Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging
    Toon A B van Veen
    Heart Lung Center, Department of Medical Physiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Circulation 112:1927-35. 2005
    ..The SCN5A sodium channel is a major determinant for cardiac impulse propagation. We used epicardial mapping of the atria, ventricles, and septae to investigate conduction velocity (CV) in Scn5a heterozygous young and old mice...
  30. ncbi Left ventricular non-compaction: insights from cardiovascular magnetic resonance imaging
    Steffen E Petersen
    University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom
    J Am Coll Cardiol 46:101-5. 2005
    ..We hypothesized that pathological trabeculation could be distinguished by determining the ratio of non-compacted to compacted myocardium (NC/C ratio)...
  31. ncbi Impact of arterial stiffening on left ventricular structure
    M J Roman
    Division of Cardiology and the Hypertension Center, Department of Medicine, Cornell University Medical College, New York, NY, USA
    Hypertension 36:489-94. 2000
  32. ncbi Clinical value of real-time three-dimensional echocardiography for right ventricular quantification in congenital heart disease: validation with cardiac magnetic resonance imaging
    Heleen B van der Zwaan
    Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Am Soc Echocardiogr 23:134-40. 2010
  33. ncbi Sex differences in mechanisms of cardiac excitation-contraction coupling in rat ventricular myocytes
    Spring R Farrell
    Department of Pharmacology, Dalhousie University, 5850 College St, Halifax, Nova Scotia, Canada
    Am J Physiol Heart Circ Physiol 299:H36-45. 2010
    ..Thus, differences in cardiac contractile function arise, in part, from differences in unitary Ca(2+) release between the sexes...
  34. pmc Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart
    Alexander R Lyon
    Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College, London SW3 6LY, United Kingdom
    Proc Natl Acad Sci U S A 106:6854-9. 2009
    ..This study confirms the loss of T-tubules as part of the phenotypic change in the failing human myocyte, but it also shows that this is part of a wider spectrum of alterations in surface morphology...
  35. ncbi Association of obesity with left ventricular remodeling and diastolic dysfunction in patients without coronary artery disease
    Brian D Powell
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
    Am J Cardiol 98:116-20. 2006
    ..In conclusion, ventricular remodeling, LV diastolic dysfunction, and elevated filling pressures may contribute to the prevalence of heart failure in obese patients...
  36. ncbi Dynamic assessment of right ventricular volumes and function by real-time three-dimensional echocardiography: a comparison study with magnetic resonance imaging in 100 adult patients
    Gregor Leibundgut
    Department of Cardiology, University Hospital Basel, Basel, Switzerland
    J Am Soc Echocardiogr 23:116-26. 2010
    ..The aim of this study was to validate a novel real-time three-dimensional echocardiographic (RT3DE) analysis tool for the determination of right ventricular volumes and function in unselected adult patients...
  37. pmc Left ventricular global transcriptional profiling in human end-stage dilated cardiomyopathy
    Dilek Colak
    Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Genomics 94:20-31. 2009
    ..Our data demonstrate an association of DCM with alterations in various cellular events and multiple yet undeciphered genes that may contribute to heart muscle disease pathways...
  38. ncbi Mouse model of SCN5A-linked hereditary Lenègre's disease: age-related conduction slowing and myocardial fibrosis
    Anne Royer
    INSERM U533, Institut du Thorax, Faculte de Medecine, Nantes, France
    Circulation 111:1738-46. 2005
    ..In the present study, we investigated heterozygous Scn5a-knockout mice (Scn5a+/- mice) as a model for hereditary Lenègre's disease...
  39. pmc Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current
    Albertas I Undrovinas
    Heart and Vascular Institute, Henry Ford Hospital, Detroit, Michigan 48202 2689, USA
    J Cardiovasc Electrophysiol 17:S169-S177. 2006
  40. ncbi Regional localisation of left ventricular sheet structure: integration with current models of cardiac fibre, sheet and band structure
    Stephen H Gilbert
    Computational Biology Laboratory, Institute of Membrane and Systems Biology and Cardiovascular Research Institute, Worsley Building, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
    Eur J Cardiothorac Surg 32:231-49. 2007
  41. ncbi Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation
    Paul G A Volders
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, PO Box 5800, 6202 AZ, Maastricht, Netherlands
    Circulation 107:2753-60. 2003
    ..In large mammals and humans, the contribution of IKs to ventricular repolarization is still incompletely understood...
  42. ncbi Cardiovascular function in multi-ethnic study of atherosclerosis: normal values by age, sex, and ethnicity
    Shunsuke Natori
    Department of Radiology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    AJR Am J Roentgenol 186:S357-65. 2006
    ..The purpose of this study was to describe the imaging protocol and normal values of left ventricular (LV) function and mass in the Multi-Ethnic Study of Atherosclerosis (MESA)...
  43. pmc Susceptibility to arrhythmia in the infarcted heart depends on myofibroblast density
    Kathleen S McDowell
    The Johns Hopkins University, Department of Biomedical Engineering and Institute for Computational Medicine, Baltimore, Maryland, USA
    Biophys J 101:1307-15. 2011
    ..At high densities, Mfbs protect against arrhythmia by causing resting depolarization and blocking propagation, thus overcoming the arrhythmogenic effects of PZ ionic current remodeling...
  44. pmc Sex and race differences in right ventricular structure and function: the multi-ethnic study of atherosclerosis-right ventricle study
    Steven M Kawut
    Penn Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Circulation 123:2542-51. 2011
    ..We examined the demographic factors associated with RV morphology and function in a population-based multiethnic sample free of clinical cardiovascular disease...
  45. ncbi Mutations in sarcomere protein genes in left ventricular noncompaction
    Sabine Klaassen
    Max Delbruck Center for Molecular Medicine, Robert Roessle Strasse 10, 13092 Berlin, Germany
    Circulation 117:2893-901. 2008
    ..We speculated that mutations in sarcomere protein genes known to cause hypertrophic cardiomyopathy and dilated cardiomyopathy may be associated with left ventricular noncompaction...
  46. pmc Left ventricular form and function revisited: applied translational science to cardiovascular ultrasound imaging
    Partho P Sengupta
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
    J Am Soc Echocardiogr 20:539-51. 2007
    ..This review examines the structure and function of the left ventricle relative to the potential clinical application of DTI and speckle tracking in assessing the global mechanical sequence of the left ventricle in vivo...
  47. pmc Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventricles
    Sylvain Brunet
    Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 South Euclid Avenue, Box 8103, St Louis, MO 63110 1093, USA
    J Physiol 559:103-20. 2004
  48. pmc A computational model of the human left-ventricular epicardial myocyte
    Vivek Iyer
    The Center for Cardiovascular Bioinformatics and Modeling and The Whitaker Biomedical Engineering Institute, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, Maryland 21093, USA
    Biophys J 87:1507-25. 2004
    ..The model therefore serves as a useful tool for investigating mechanisms of arrhythmia and consequences of drug-channel interactions in the human left-ventricular myocyte...
  49. ncbi The effects of obesity, gender, and ethnic group on left ventricular hypertrophy and geometry in hypertensive children: a collaborative study of the International Pediatric Hypertension Association
    Coral Hanevold
    Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912 3795, USA
    Pediatrics 113:328-33. 2004
    ..To determine the prevalence of left ventricular hypertrophy (LVH) in a multiethnic group of children and adolescents with hypertension...
  50. ncbi Normal range of left ventricular 2-dimensional strain: Japanese Ultrasound Speckle Tracking of the Left Ventricle (JUSTICE) study
    Kiyohiro Takigiku
    Nagano Children s Hospital, Azumino, Japan
    Circ J 76:2623-32. 2012
    ..To determine the normal range of left ventricular (LV) 2- dimensional (2-D) strain and vendor-specific differences, a multicenter prospective 2-D strain study endorsed by the Japanese Society of Echocardiography was conducted...
  51. ncbi Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures
    S F Nagueh
    Baylor College of Medicine and Department of Medicine, The Methodist Hospital, Houston, Texas 77030, USA
    J Am Coll Cardiol 30:1527-33. 1997
  52. ncbi Obstructive sleep apnea: effects of continuous positive airway pressure on cardiac remodeling as assessed by cardiac biomarkers, echocardiography, and cardiac MRI
    Jane Colish
    Department of Internal Medicine, St Boniface General Hospital, Winnipeg, Manitoba, Canada
    Chest 141:674-81. 2012
  53. pmc Semi-automatic segmentation of myocardium at risk in T2-weighted cardiovascular magnetic resonance
    Jane Sjögren
    Department of Clinical Physiology, Skane University Hospital, Lund University, Lund, Sweden
    J Cardiovasc Magn Reson 14:10. 2012
    ..Therefore, the aim of this study was to develop an automatic segmentation algorithm for quantification of MaR using anatomical a priori information...
  54. ncbi Viral gene transfer rescues arrhythmogenic phenotype and ultrastructural abnormalities in adult calsequestrin-null mice with inherited arrhythmias
    Marco Denegri
    Molecular Cardiology, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy
    Circ Res 110:663-8. 2012
  55. ncbi A finite element model of the human left ventricular systole
    F Dorri
    Institute for Biomedical Engineering, University and ETH Zurich, Gloriastrasse 35, CH 8092, Zurich, Switzerland
    Comput Methods Biomech Biomed Engin 9:319-41. 2006
    ..We therefore, expect that the measurement of systolic deformation might provide useful diagnostic information...
  56. pmc Nonequilibrium arrhythmic states and transitions in a mathematical model for diffuse fibrosis in human cardiac tissue
    Rupamanjari Majumder
    Centre for Condensed Matter Theory, Department of Physics, Indian Institute of Science, Bangalore, India
    PLoS ONE 7:e45040. 2012
    ..We explore possible experimental implications of our mathematical and numerical studies for plane-, spiral-, and scroll-wave dynamics in cardiac tissue with fibrosis...
  57. ncbi Mutations in Cypher/ZASP in patients with dilated cardiomyopathy and left ventricular non-compaction
    Matteo Vatta
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, Texas, USA
    J Am Coll Cardiol 42:2014-27. 2003
    ..We evaluated the role of Cypher/ZASP in the pathogenesis of dilated cardiomyopathy (DCM) with or without isolated non-compaction of the left ventricular myocardium (INLVM)...
  58. pmc MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor beta1 in neonatal rat ventricular myocytes
    Hitoo Nishi
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Mol Cell Biol 31:744-55. 2011
    ..These findings suggested that miR-27a regulates β-MHC gene expression by targeting TRβ1 in cardiomyocytes...
  59. ncbi Two-dimensional speckle tracking of the left ventricle in patients with systemic sclerosis for an early detection of myocardial involvement
    Sebastian Spethmann
    Medizinische Klinik für Kardiologie und Angiologie, Campus Mitte, Charite Universitatsmedizin Berlin, Chariteplatz 1, Berlin D 10117, Germany
    Eur Heart J Cardiovasc Imaging 13:863-70. 2012
    ..The aim of this study was to evaluate deformation analyses derived from STE for early detection of LV systolic dysfunction in patients with SSc having preserved left ventricular ejection fraction (LVEF)...
  60. ncbi Ovariectomy enhances SR Ca²⁺ release and increases Ca²⁺ spark amplitudes in isolated ventricular myocytes
    Elias Fares
    Department of Pharmacology, 5850 College Street, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    J Mol Cell Cardiol 52:32-42. 2012
    ..These observations show that OVX disrupts intracellular Ca(2+) homeostasis and suggest that sex steroid hormones modulate unitary Ca(2+) release in individual cardiac myocytes...
  61. ncbi Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation
    Daniel M Johnson
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
    Circ Res 112:246-56. 2013
    ..Excessive beat-to-beat variability of repolarization duration (BVR) is a proarrhythmic marker. Previous research has shown that BVR is increased during intense β-adrenergic stimulation, leading to SCR...
  62. pmc Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension
    Jennifer A Johnson
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 302:L474-84. 2012
    ..Together, these findings suggest that cytoskeletal function is central to the development of BMPR2-associated PAH and that intervention against cytoskeletal defects may reverse established disease...
  63. pmc Left ventricular torsion, energetics, and diastolic function in normal human aging
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    Am J Physiol Heart Circ Physiol 302:H885-92. 2012
    ..34, not significant (NS) and TSR vs. PCr/ATP: r = -0.3, P = NS]. In normal aging, changes in EFP and TSR likely share the same pathophysiology, although it is unlikely that energetics have a major role in the functional effects of aging...
  64. pmc Small-conductance calcium-activated potassium channel and recurrent ventricular fibrillation in failing rabbit ventricles
    Su Kiat Chua
    Krannert Institute of Cardiology, Division of Cardiology, Indiana University School of Medicine, Indianapolis, USA
    Circ Res 108:971-9. 2011
    ..Fibrillation/defibrillation episodes in failing ventricles may be followed by action potential duration (APD) shortening and recurrent spontaneous ventricular fibrillation (SVF)...
  65. pmc Physical activity and right ventricular structure and function. The MESA-Right Ventricle Study
    Carrie P Aaron
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 183:396-404. 2011
    ..Intense exercise in elite athletes is associated with increased left ventricular (LV) and right ventricular (RV) mass and volumes. However, the effect of physical activity on the RV in an older community-based population is unknown...
  66. ncbi Comparative influence of load versus inotropic states on indexes of ventricular contractility: experimental and theoretical analysis based on pressure-volume relationships
    D A Kass
    Johns Hopkins Medical Institutions, Department of Medicine, Baltimore, MD
    Circulation 76:1422-36. 1987
    ..Any advantage of the ESPVR will derive not from the magnitude of its response to inotropic change, which is smaller than most other indexes, but from its relative insensitivity to load alteration over a wider range of load...
  67. pmc Relation of cardiovascular risk factors to right ventricular structure and function as determined by magnetic resonance imaging (results from the multi-ethnic study of atherosclerosis)
    Harjit Chahal
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 106:110-6. 2010
    ..Cardiovascular risk factors, especially blood pressure and high-density lipoprotein cholesterol, are associated with subclinical changes in the RV mass and volume...
  68. ncbi A review of segmentation methods in short axis cardiac MR images
    Caroline Petitjean
    Universite de Rouen, LITIS EA 4108, BP 12, 76801 Saint Etienne du Rouvray, France
    Med Image Anal 15:169-84. 2011
    ..After reviewing method principles and analyzing segmentation results, we conclude with a discussion and future trends in this field regarding methodological and medical issues...
  69. pmc Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease
    Farah Sheikh
    Department of Medicine, UCSD, La Jolla, California 92093 0613C, USA
    J Clin Invest 122:1209-21. 2012
    ..Thus, there is a direct and early role for Mlc2 phosphorylation in regulating actin-myosin interactions in striated muscle contraction, and dephosphorylation of Mlc2 or loss of these mechanisms can play a critical role in heart failure...
  70. ncbi Selection of reference genes for normalization of real-time PCR data in minipig heart failure model and evaluation of TNF-α mRNA expression
    Alessandro Martino
    University of Pisa, Department of Biology, Genetics Division, Italy
    J Biotechnol 153:92-9. 2011
    ..The use of unvalidated reference genes can generate biased results because also their expression could be altered by the experimental conditions...
  71. ncbi Differences in left ventricular twist related to age: speckle tracking echocardiographic data for healthy volunteers from neonate to age 70 years
    Yi Zhang
    Department of Ultrasound, the People s Hospital of HuNan province Changsha, China
    Echocardiography 27:1205-10. 2010
    ..To determine normal left ventricular (LV) twist characteristics in different age groups and assess changes between neonates and the elderly...
  72. ncbi Changing pattern of gene expression is associated with ventricular myocyte dysfunction and altered mechanisms of Ca2+ signalling in young type 2 Zucker diabetic fatty rat heart
    F C Howarth
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, UAE
    Exp Physiol 96:325-37. 2011
    ..A change in the expression of genes encoding myosin heavy chain and L-type Ca(2+) channel proteins might partly underlie alterations in the time course of contraction and Ca(2+) transients in ventricular myocytes from ZDF rats...
  73. ncbi Imaging the right ventricle--current state of the art
    Luc L Mertens
    The Labatt Family Heart Center, Division of Cardiology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Nat Rev Cardiol 7:551-63. 2010
  74. ncbi Vagus nerve stimulation protects against ventricular fibrillation independent of muscarinic receptor activation
    Kieran E Brack
    Department of Cardiovascular Sciences, Cardiology Group, University of Leicester, Glenfield Hospital, Leicester, UK
    Cardiovasc Res 91:437-46. 2011
    ..In addition, the role of the coronary endothelium and afferent nerves was tested...
  75. ncbi Arterial stiffness and left-ventricular diastolic dysfunction: Guangzhou Biobank Cohort Study-CVD
    L Xu
    Department of Community Medicine, School of Public Health, University of Hong Kong, Hong Kong, PR China
    J Hum Hypertens 25:152-8. 2011
    ..0). Our study suggested that increased baPWV might be an independent risk factor or marker for diastolic dysfunction. Early detection of an intervention on increased baPWV may be important for prevention of cardiac diastolic dysfunction...
  76. ncbi Optimal left ventricular endocardial pacing sites for cardiac resynchronization therapy in patients with ischemic cardiomyopathy
    David D Spragg
    Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Am Coll Cardiol 56:774-81. 2010
    ..We sought to investigate the impact of left ventricular (LV) pacing site on mechanical response to cardiac resynchronization therapy (CRT) in patients with ischemic cardiomyopathy (ICM)...
  77. pmc Right ventricular cardiomyocyte apoptosis in patients with acute myocardial infarction of the left ventricular wall
    Antonio Abbate
    Virginia Commonwealth University, Pauley Heart Center, Richmond, Virginia, USA
    Am J Cardiol 102:658-62. 2008
    ..91, p = 0.002 for RV free wall thickness). In conclusion, patients with cardiac remodeling after AMI had a significant increase in RV apoptosis even when ischemic involvement of the RV wall was not apparent...
  78. ncbi Real-time 3-dimensional echocardiographic quantification of left ventricular volumes: multicenter study for validation with magnetic resonance imaging and investigation of sources of error
    Victor Mor-Avi
    University of Chicago Medical Center, Chicago, Illinois 60637, USA
    JACC Cardiovasc Imaging 1:413-23. 2008
  79. ncbi Cell-based therapy for myocardial repair in patients with acute myocardial infarction: rationale and study design of the SWiss multicenter Intracoronary Stem cells Study in Acute Myocardial Infarction (SWISS-AMI)
    Daniel Sürder
    Department of Cardiology, University Hospital Zurich, Zurich, Switzerland
    Am Heart J 160:58-64. 2010
    ..Furthermore, reliable clinical predictors are lacking for identifying patients who are thought to have most benefit from cellular therapy...
  80. ncbi Reference values for right ventricular volumes and ejection fraction with real-time three-dimensional echocardiography: evaluation in a large series of normal subjects
    Gloria Tamborini
    Centro Cardiologico Monzino, IRCCS, Department of Cardiovascular Sciences, University of Milan, Milan, Italy
    J Am Soc Echocardiogr 23:109-15. 2010
    ..The aim of this study was to provide normal reference values for RV volumes and function using this technique...
  81. ncbi Multimodality comparison of quantitative volumetric analysis of the right ventricle
    Lissa Sugeng
    University of Chicago Medical Center, Chicago, Illinois 60637, USA
    JACC Cardiovasc Imaging 3:10-8. 2010
  82. pmc Three-dimensional echocardiography using single-heartbeat modality decreases variability in measuring left ventricular volumes and function in comparison to four-beat technique in atrial fibrillation
    Kambiz Shahgaldi
    Department of Cardiology, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Cardiovasc Ultrasound 8:45. 2010
  83. ncbi L-type Ca(2+) current in ventricular cardiomyocytes
    Jean Pierre Benitah
    INSERM, U637, Universite Montpellier, France
    J Mol Cell Cardiol 48:26-36. 2010
  84. ncbi Prevention of ventricular fibrillation episodes in Brugada syndrome by catheter ablation over the anterior right ventricular outflow tract epicardium
    Koonlawee Nademanee
    Pacific Rim Electrophysiology Research Institute, 1700 Cesar E Chavez Avenue, Los Angeles, CA 90033, USA
    Circulation 123:1270-9. 2011
  85. ncbi Impact of glucose intolerance and insulin resistance on cardiac structure and function: sex-related differences in the Framingham Heart Study
    Martin K Rutter
    Framingham Heart Study, Burlington, Mass, USA
    Circulation 107:448-54. 2003
    ..Although insulin resistance has been implicated in the pathogenesis of left ventricular (LV) hypertrophy, previous studies have yielded inconsistent results and are limited by referral bias...
  86. ncbi Altered connexin43 expression produces arrhythmia substrate in heart failure
    Steven Poelzing
    MetroHealth Campus, Case Western Reserve University, 2500 MetroHealth Drive, Hamman 330, Cleveland, OH 44109 1998, USA
    Am J Physiol Heart Circ Physiol 287:H1762-70. 2004
    ..Therefore, Cx43 expression patterns can potentially contribute to an arrhythmic substrate in failing myocardium...
  87. ncbi Ventricular untwisting: a temporal link between left ventricular relaxation and suction
    Yuichi Notomi
    Department of Cardiovascular Medicine F15, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Physiol Heart Circ Physiol 294:H505-13. 2008
    ..Untwisting rate may be a useful marker of diastolic function or even serve as a therapeutic target for improving diastolic function...
  88. pmc Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis
    Amrita X Sarkar
    Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Heart Rhythm 8:1749-55. 2011
    ..However, the mechanisms underlying this interindividual variability are not understood quantitatively...
  89. ncbi Favorable effects of resveratrol on sympathetic neural remodeling in rats following myocardial infarction
    Ping Xin
    Division of Cardiology, Shanghai Sixth Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
    Eur J Pharmacol 649:293-300. 2010
  90. ncbi Heart rate variability measurements and the prediction of ventricular arrhythmias
    M J Reed
    Emergency Department, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK
    QJM 98:87-95. 2005
  91. ncbi Cardiac myocyte-nonmyocyte electrotonic coupling: implications for ventricular arrhythmogenesis
    Peter Kohl
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Heart Rhythm 4:233-5. 2007
  92. ncbi Adult ventricular cardiomyocytes: isolation and culture
    Klaus Dieter Schluter
    Physiologisches Institut, Justus Liebig Universitat Giessen, Germany
    Methods Mol Biol 290:305-14. 2005
    ..The chapter also summarizes some commonly used adaptations to isolate cardiomyocytes from species different from rat...
  93. ncbi Intensity-controlled treadmill running in mice: cardiac and skeletal muscle hypertrophy
    Ole Johan Kemi
    Department of Physiology and Biomedical Engineering, Norwegian University of Science and Technology, N 7489 Trondheim, Norway
    J Appl Physiol 93:1301-9. 2002
    ..Thus the model mimics human responses to exercise and can be used in future studies of molecular mechanisms underlying these adaptations...
  94. ncbi Prognostic significance of left ventricular mass change during treatment of hypertension
    Richard B Devereux
    Department of Medicine, New York Presbyterian Hospital, Cornell Medical Center, New York, NY 10021, USA
    JAMA 292:2350-6. 2004
    ..Increased baseline left ventricular (LV) mass predicts cardiovascular (CV) complications of hypertension, but the relation between lower LV mass and outcome during treatment for hypertension is uncertain...
  95. ncbi Effect of resynchronization therapy stimulation site on the systolic function of heart failure patients
    C Butter
    , Campus Virchow Klinikum, Berlin, Germany
    Circulation 104:3026-9. 2001
    ..Further studies are warranted to prove the clinical superiority of the LV free wall as a site for long-term CRT...
  96. ncbi Homogeneity of cardiac contraction despite physiological asynchrony of depolarization: a model study
    R C P Kerckhoffs
    Department of Biomedical Engineering, Eindhoven University of Technology, Whoog 4 105, P O Box 513, 5600 Eindhoven, The Netherlands
    Ann Biomed Eng 31:536-47. 2003
    ..The present finding may indicate that electromechanical delay times are heterogeneously distributed, such that a contraction in a normal heart is more synchronous than depolarization...
  97. ncbi Cardiac mechanics in mild hypertensive heart disease: a speckle-strain imaging study
    Arumugam Narayanan
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01606, USA
    Circ Cardiovasc Imaging 2:382-90. 2009
    ..The aim of the current case-control study was to use speckle tracking imaging to identify subclinical global and regional systolic function abnormalities in hypertensive subjects with normal ejection fraction...
  98. ncbi Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: noninvasive assessment with doppler echocardiography and contribution of the nitric oxide pathway
    I I Joffe
    Charles A Dana Research Institute, Boston, Massachusetts, USA
    J Am Coll Cardiol 34:2111-9. 1999
    ..We sought to evaluate in vivo and in vitro left ventricular (LV) geometry and function in streptozotocin-induced diabetic rats and the possible role of the nitric oxide (NO) pathway...
  99. ncbi Differences in atrial versus ventricular remodeling in dogs with ventricular tachypacing-induced congestive heart failure
    Nessrine Hanna
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    Cardiovasc Res 63:236-44. 2004
    ..Congestive heart failure (CHF) causes arrhythmogenic remodeling in both atria and ventricles, but differences between atrial and ventricular remodeling in CHF have not been well characterized...
  100. ncbi Left ventricular morphology, global and longitudinal function in normal older individuals: a cardiac magnetic resonance study
    Nikolay P Nikitin
    Academic Department of Cardiology, The University of Hull, Castle Hill Hospital, Castle Road, Cottingham, Kingston upon Hull, HU16 5JQ United Kingdom
    Int J Cardiol 108:76-83. 2006
    ..This study was designed to assess left ventricular (LV) morphology, global and longitudinal function in healthy older men and women using cardiac magnetic resonance (CMR)...
  101. ncbi I(Ks) restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulation
    Daniel M Johnson
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
    J Mol Cell Cardiol 48:122-30. 2010
    ..Loss of I(Ks) plus overriding of Ca(2+)-dependent membrane currents, including inward Na(+)-Ca(2)(+) exchange current, conspire to proarrhythmic BVR under these conditions...

Research Grants71

  1. Hypertension and Collagen: Effect of Ac-SDKP
    Nour Eddine Rhaleb; Fiscal Year: 2010
    ..Consequently, it will identify another component (Ac-SDKP) as part of the multiple mediators participating in the cardioprotective effects of ACEi in hypertension. ..
    Vijay Sharma; Fiscal Year: 2013
    ..Successful execution of the outlined objectives should provide a molecular-targeted 68Ga-PET agent for MPI and management of CAD. ..
  3. Modulation of Natriuretic Peptides via Caveolin in Hypertrophy and Heart Failure.
    David M Roth; Fiscal Year: 2013
    ..The work described in this proposal focuses on elucidating mechanisms to support the use of caveolin proteins as novel therapeutic targets for heart failure patients and is of relevance to the VA patient care mission. ..
  4. AKAP Regulation of PKA Targeting in the Heart
    Meredith Bond; Fiscal Year: 2009
    ..Our project investigates a novel nuclear AKAP protein, Chd8 that may participate in regulation of cardiac remodeling during ischemic heart failure. ..
  5. Identification and Validation of Alcohol Biomarker Signatures by Proteomics
    Emanuel Rubin; Fiscal Year: 2010
    ..Early diagnosis of this condition by specific biomarkers will offer the opportunity for treatment and prevention of heart enlargement, congestive heart failure and death. ..
  6. Cardiac Autonomic Neuropathy and Myocardial Dysfunction in Type 1 Diabetes
    RODICA BUSUI POP-BUSUI; Fiscal Year: 2013
    ..These studies will help elucidate mechanisms of myocardial dysfunction in T1DM with ultimate goal of designing future studies implementing therapeutic strategies aimed at preventing increased cardiovascular risk in patients with T1DM. ..
  7. Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)
    R Graham Barr; Fiscal Year: 2011
    ..If confirmed, this hypothesis would lead to the testing of currently available (e.g., statins) and novel (e.g., stem cell) therapies targeted to the endothelium in COPD. ..
  8. Physiology and Biophysics of Cardiac Slo2.1 Channels
    Alexey V Zaitsev; Fiscal Year: 2012
    ..These electrical gradients are highly relevant to the outcomes of cardiac defibrillation and resuscitation of individuals who have experienced sudden cardiac arrest. ..
  9. Cardiopulmonary structure and function in Multi-Ethnic Study of Atherosclerosis
    R Graham Barr; Fiscal Year: 2013
    ..PHS 398 (Rev. 5/01) Page Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. ..
  10. Intravascular Cardiac Assist System for Decompression and Recovery
    CAITLYN J BOSECKER; Fiscal Year: 2010
    ..S. alone) and, hypothetically, may have a very significant total market potential (estimated at $0.8 to $1.0 billion). ..
  11. Self-Sensing Physiologic Control of a Rotary Mag Lev LVAD
    JAMES FARLEY WALTON; Fiscal Year: 2010
    ..The success of early developments has resulted in the use of circulatory assistance for short durations [2, 3, 4], however new developments are needed to make long duration use of these heart assist devices possible. ..
  12. Role of miRNAs in Vascular Physiology
    Akiko Hata; Fiscal Year: 2012
    ..This application will elucidate a novel mechanism of regulation of VSMC phenotype in normal physiology, which is of fundamental importance in understanding the etiology of cardiovascular disorders. ..
  13. The Role of Histone Deacytelases in Right Ventricular Adaptation in Hypoplastic L
    SHELLEY DEANNE MIYAMOTO; Fiscal Year: 2013
    ..Modulation of HDAC activity, given the distal site of action in the signaling pathway, could have unique therapeutic potential in RV failure in HLHS. ..
  14. Randomized trial of inhaled nitric oxide to treat acute pulmonary embolism
    Jeffrey A Kline; Fiscal Year: 2013
    ..if NO+O2 corrects defective platelet oxidative metabolism associated with PE, and reduces release of CF DNA/RNA coincident with reduced clotting time and strength on thromboelastography. ..
  15. Exercise and H2S mitigate homocysteine-mediated beta2-adrenergic receptor dysfunc
    Paras Kumar Mishra; Fiscal Year: 2013
    ..These studies will elucidate the mechanism of homocysteine-mediated attenuation of [unreadable]2-AR in diabetes and cardio-protective role of [unreadable]2-AR agonist, exercise and H2S in diabetic complications. ..
  16. Mitochondrial Matrix Metalloproteinase-2 and Cardiac Injury
    David H Lovett; Fiscal Year: 2013
    ..In addition, congestive heart failure caused by defects in the pumping ability of the heart ventricles is a leading contributor to morbidity and mortality in the veteran population...
  17. Control of Cardiac Lineage Commitment and Differentiation in Murine Development
    Ibrahim J Domian; Fiscal Year: 2013
    ..Understanding how the heart develops will help us understand how the heart becomes diseased. This study will give us clues for the future on how to diagnose and treat cardiac birth defects and adult diseases. ..
  18. Factors that Initiate Arrhythamias in Long QT Syndrome
    Guy Salama; Fiscal Year: 2006
    ..Stimulation paradigms that i) enhance DOR or ii) elicit a bradycardia followed by a tachycardia are more likely to increase the incidence of EADs or TdP. ..
  19. Intrauterine hypoxia induces cytokine gene expression in fetal cardiac ventricles
    LASHAUNA C EVANS; Fiscal Year: 2010
    ..These proposed studies will aid in our understanding of the underlying mechanisms associated with cardioprotection, injury, as well as fetal programming during intrauterine stress. ..
  20. Disease Mechanisms in ARVC
    Jeffrey E Saffitz; Fiscal Year: 2013
    ..Our ultimate goal is to help develop mechanism-based therapies to prevent sudden death. ..
  21. Role of Chymase In The Post-Myocardial Infarction Heart
    Ahsan Husain; Fiscal Year: 2013
    ..The proposed identification of the downstream targets of chymase should provide a foundation for the development of novel therapeutic agents directed toward patients with cardiovascular disease. ..
  22. Right Heart Function in Health and Chronic Lung Disease
    Anthony J Baker; Fiscal Year: 2013
    ..This project will explore such a new approach. ..
  23. Neural Crest Modulates FGF Signaling in the Pharynx
    Margaret Loewy Kirby; Fiscal Year: 2010
    ..Together these studies will advance the mechanistic understanding of neural crest function in heart development and will provide insight into factors that cause conotruncal malformations. ..
  24. Particle-Induced Cardiac Effects in Senescent Mice
    Clarke Tankersley; Fiscal Year: 2009
    ..We believe this research plan uniquely examines plausible biological mechanisms to better understand the mortality risk which threatens susceptible elderly populations during episodes of poor air quality. ..
  25. Regulation of sympathetic function by infarction
    Beth A Habecker; Fiscal Year: 2013
    ..This work tests novel hypotheses concerning sympathetic neuroplasticity that may provide a molecular basis for increased post-MI arrhythmias, and may ultimately lead to the development of new therapeutics. ..
  26. Bioenergetics in Hypertrophied and Remodeled Left Ventricle
    Jianyi Zhang; Fiscal Year: 2013
    ..The findings of these studies will advance our understanding of the mechanisms of cellular therapy in myocardial repair, and lead to better diagnostic and therapeutic modalities for CHF patients. ..
  27. Endothelial Myocyte Matrix in Cardiac Remodeling
    Suresh C Tyagi; Fiscal Year: 2013
    ..PHS 398/2590 (Rev. 11/07) Page Continuation Format Page ..
    Patrick Y Jay; Fiscal Year: 2013
    ..Characterization of the genetic architecture of congenital heart disease in a mouse model will lead to a deeper understanding of its multifactorial basis and possibly novel strategies for prognosis and prevention. ..
  29. O2 sensing in the human and rabbit ductus arteriosus.
    Stephen L Archer; Fiscal Year: 2013
    ..Since HOSK may have arisen independent of the canonical K+ channel family, exploring its structure-function relationship will extend our fundamental knowledge K+ channels. ..
  30. Computational Tools to Describe Cardiac Post-MI Structure and Function Remodeling
    Siamak Ardekani; Fiscal Year: 2012
  31. Prevention of heart failure and death by sphingolipids: outcomes and mechanisms.
    JOEL KARLINER; Fiscal Year: 2009
    ..Worsening heart failure hospitalization epidemic. J Amer Coll Cardiol. 2008;435-437. 3. National Survey of Veterans, National Center for Veterans Analysis and Statistics. http://www1.va.gov/vetdata/docs/survey_final.htm (2001). ..
  32. Targeted Delivery of iPS-Endothelial Cells for the Repair of Cardiovascular Injur
    Yiu Fai Chen; Fiscal Year: 2013
    ..In addition, it is expected that the results wll fundamentally advance the field of cell-based therapy by providing a noninvasive and cost effective treatment modality. ..
  33. Reactivation of breast cancer micrometastases by senescent bone marrow stroma
    Robert Wieder; Fiscal Year: 2010
    ..Experiments will determine if treatment with estrogen or anti-inflammatory agents can restore the capacity of senescent stroma to support dormancy. ..
  34. Novel calcium buffer for the treatment of diastolic heart failure
    Michelle L Asp; Fiscal Year: 2013
    ..Collectively, this experimental plan will enable new insights into Ca2+ mishandling in DHF and establish fundamental knowledge on using Ca2+ buffers to treat the failing heart. ..
  35. Conduction System Remodeling After Myocardial Infarction
    TERRENCE XAVIER O'BRIEN; Fiscal Year: 2011
  36. Characterization of Cardiac Progenitors Derived from 22q11-deleted Patients
    WILLIAM TSWENCHING contact PU; Fiscal Year: 2010
    ..These studies will yield unique insights into how 22q11 deletion causes this form of congenital heart disease. ..
  37. Conotruncal defects: genetic and nutritional risk
    EDWARD JAMES LAMMER; Fiscal Year: 2010
  38. Single Molecule Studies of Titin Elasticity
    Julio M Fernandez; Fiscal Year: 2013
    ..A highly developed version of this model may be used to evaluate the severity of heart muscle phenotypes in humans that are discovered to have mutations in the titin gene. ..
  39. The Role of Macrophage-Derived MMP-9 in LV Remodeling
    Merry L Lindsey; Fiscal Year: 2013
    ..Our multi-faceted approach will further advance the mechanistic understanding of the events that initiate post-MI LV remodeling, which may provide targets for translational research. ..
  40. A Novel F-18 PET Myocardial Perfusion Radiopharmaceutical based on Rhodamine Dyes
    ALAN BRENT PACKARD; Fiscal Year: 2013
    ..The objective of this project is to develop an 18F-labeled imaging agent for use in this procedure that will circumvent the limits of the existing agents. ..
  41. Fibroblasts and Mononuclear Fibrogenic Cells Drive Right Ventricular Pulmonary Ar
    Kurt R Stenmark; Fiscal Year: 2013
    ..Collectively, work by this interdisciplinary group will provide insight into abnormalities of RV-pulmonary arterial interactions in the setting of severe pulmonary hypertension and will lay the groundwork for potential new therapies. ..
  42. Titin-based adaptations of cardiac function
    Henk L Granzier; Fiscal Year: 2013
  43. Regulation of Arginase in Models of Pulmonary Hypertension
    Bernadette Chen; Fiscal Year: 2013
    Thomas Force; Fiscal Year: 2013
    ..The latter studies could lead to alternative strategies to traditional b-blockade, with the additional advantage that deletion (or inhibition) of GSK- 3a, unlike b-blockers, leads to improved glucose tolerance and insulin sensitivity. ..
  45. Regulation of Myocardial Regeneration in Zebrafish
    Kenneth D Poss; Fiscal Year: 2013
  46. Compliant Thoracic Artificial Lungs
    KEITH ELLIOT COOK; Fiscal Year: 2012
    ..These devices will give chronic lung disease patients more time to find a donor lung and improve their health before and after transplantation. ..
  47. Pediatric Heart Network Regents of the University of Michigan
    Richard G Ohye; Fiscal Year: 2013
    ..The proposed trial targets this high risk time for children with FSRV. ..
  48. iPSC-Derived Cardiomyocytes in Left Ventricular Non-Compaction Cardiomyopathy
    Daniel Bernstein; Fiscal Year: 2013
    ..End of Abstract) ..
  49. Development Underpinnings of Acquired Aortic Aneurysm in Marfan Syndrome
    Mark E Lindsay; Fiscal Year: 2013
    ..Importantly, we believe this early SHF dysregulation may initiate the pathogenic sequence as well as define the anatomic susceptibility to aneurysm in the proximal aorta in MFS. ..
  50. Restoring LV Function Post-MI Using Fibrin-Gel Based Engineered Myocardium
    Lauren D Black; Fiscal Year: 2012
    ..The results of this research may help elucidate design parameters that are critical to the creation of functional myocardium engineered in vitro and thus advance the concept of the "heart patch" closer to reality ..
    Anthony B Firulli; Fiscal Year: 2011
    ..Specific Aim 2 will determine what motifs distinguish Handl and Hand2 function and how Handl and 2 functionally interact with Hey2. ..
  52. The Mas Receptor is Required for Angiotensin-(1-7) Effects in Cardiac Remodeling
    Barry H Greenberg; Fiscal Year: 2012
  53. Cardiac MRI-Tractography In Vivo: Integrated Imaging of Structure and Function
    David E Sosnovik; Fiscal Year: 2013
    ..DTI-tractography of the human heart in vivo is highly feasible, and the proposal is thus of major clinical and public health significance. ..
  54. Dependence of Cardiomyocyte Electrophysiology Development on Contractile Strain
    Jeffrey G Jacot; Fiscal Year: 2012
  55. Optical Mapping of the Onset of Ventricular Arrhythmias
    Jack M Rogers; Fiscal Year: 2013
    ..Many patients with nonischemic heart failure are now receiving implantable defibrillators for primary prevention of sudden death, highlighting the importance of improved understanding of defibrillation failure in this setting. ..
  56. Quantitative Molecular Imaging of Heart Failure by 123I-MIBG SPECT
    Edward Ficaro; Fiscal Year: 2010
    ..This proposal will develop imaging software necessary for advancing molecular imaging technology to the clinic practice and facilitate wider clinical adoption of this promising advance in the care of heart failure patients. ..
  57. Mathematical Modeling of Matrix Metalloproteinase-9 Driven Left Ventricular Remod
    Yufang Jin; Fiscal Year: 2010
  58. Cardiomyocyte mechanotransduction through the integrin complex
    ROBERT SCOTT ROSS; Fiscal Year: 2013
  59. Molecular Mechanisms of Stretch-Induced Electrical Remodeling in the Heart
    ..abstract_text> ..
  60. Developing an animal model of HLHS: role of immune mediated injury
    Pirooz Eghtesady; Fiscal Year: 2012
    ..A good animal model for HLHS will have a sustained impact on this field of research. ..
  61. Epigenetic control of multipotent cardiac progenitor cell differentiation
    Zhong Wang; Fiscal Year: 2013
    ..These studies will generate novel insights into epigenetic mechanisms that govern CPC differentiation and may have significant implications in understanding and treating heart disease. ..
  62. Role of PAR-1 and PAR-2 in Cardiac Remodeling
    Nigel Mackman; Fiscal Year: 2010
    ..The results may lead to the development of PAR-1 and PAR-2 inhibitors that may be used as novel therapies for the treatment of pathological cardiac remodeling and hypertrophy in humans. ..
  63. Pediatric Heart Network: Follow-up of the Single Ventricle Reconstruction Trial
    Wyman Lai; Fiscal Year: 2010
    ..The results of this multicenter, prospective study will provide important information regarding the optimal neonatal surgical intervention for this lesion. (End of Abstract) ..
    Marie Francoise Doursout; Fiscal Year: 2004
    ..After 7 days, the lungs will be analyzed to determine if connective tissue content and lung fluid have increased. These studies will test a previously unknown mechanism for the pulmonary edema associated with heart failure. ..
    TERRENCE O BRIEN; Fiscal Year: 2000
    ..Studying the genetic regulation of oxidative phosphorylation in cardiocytes subjected to hypertrophic stimulus should lead to important, physiologically relevant, insights into key initial molecular events. ..
  66. Update and modification of Task Force Criteria for ARVD/C
    Frank Marcus; Fiscal Year: 2007
    ..null ..
  67. Development of an Implantable "Plug and Play" TransApical to Aorta VAD
    Stephen Topaz; Fiscal Year: 2007
    ..Our simple, easily inserted pump will revolutionize the field of mechanical heart assist. [unreadable] [unreadable] [unreadable]..
    LYLE MOCKROS; Fiscal Year: 2000
    ..The results of the in-vitro and in-vivo studies will be used to confirm the theoretical models and direct ITAL designs for various etiologies. ..
  69. Hedgehog signaling during cardiovascular patterning in the mouse
    JOHN A KLINGENSMITH; Fiscal Year: 2010
    ..Similarly we will test the cell autonomous requirement of hedgehog signaling during A-V valve formation using genetic manipulations in the mouse. ..
    Chang Seng Liang; Fiscal Year: 1990
    Douglas Mann; Fiscal Year: 2004
    ..These studies elucidate further the molecular foundations of cardiac hypertrophy and failure and should provide a rational basis for more effective therapy. ..